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KOSAKA Kenji  小阪 憲司

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… Alternative Names

小坂 憲司  コサカ ケンジ

小阪 憲司  コサカ ケンジ

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Researcher Number 60023800
External Links
Affiliation (based on the past Project Information) *help 2003 – 2004: 横浜市立大学, 医学部, 名誉教授
1994 – 2002: Yokohama City Univercity Depertment of Psychiatry, Professor, 医学部, 教授
1992: 横浜市立大学, 医学部・精神医学教室, 教授
1990: Psychiatric Research Institute of Tokyo, Department of Neuropathology Chief, 神経病理, 副参事研究員
1990: 東京都精神医学総合研究所, 神経病理研究部門, 副参事研究員
1989: 東京都精神医学総合研究所, 神経病理研究室, 副参事研究員
Review Section/Research Field
Principal Investigator
Psychiatric science
Except Principal Investigator
Psychiatric science
Keywords
Principal Investigator
Dementia with Lewy bodies / レビー小体 / レビー小体型痴呆 / びまん性レビー小体病 / Diffuse Lewy body disease / 扁桃核 / 神経原線維変化 / 老人斑 / Alzheimer-type dementia / 免疫組織化学 … More / neurofibrillary tangle / ubiquitin / alpha-synuclein / dementia / Lewy body / diffuse Lewy body disease / エビキチン / α-シマクレイン / アセチルコリン・ムスカリン受容体 / cdk5 / タウ / アルファ・シヌクレイン / ユビキチン / α-シヌクレイン / 痴呆 / Amygdala / Apolipoprotein E / Ubiquitin-positive neurites / Lewy bodies / タウン陽性ミクログリア / ユビキチン陽性構造物 / 海面状態 / ユビキチン陽性顆粒 / ユビキチン陽性変性神経突起 / アポリポたんぱくE / ユビキチン陽性神経突起 / Biochemical findings / Intraglial tau2-positive structure / Ubiquitin-positive thread-like structure / Neurofibrillary tangle / Senile plaque / tau-2免疫染色 / ユビキチン免疫染色 / 生化学的変化 / intraglial tau_2-positive structure / ubiquitin-positive thread-like structure / Alzheimer型痴呆 / びまん性Lewy小体病 / neuropathology / immunohistochemistry / autopsied brain / ganglioside / 生化学 / 神経病理 / 剖検脳 / ガングリオシド / アルツハイマ-型痴呆 … More
Except Principal Investigator
Lewy body / α-synuclein / レビー小体 / パーキンソン病 / denepezil chloride / autonomic disturbances / visual cognitive impairments / Alzheimer's disease / Parkinson's disease with dementia / dementia with Lewy bodies / 脳画像 / 幻視 / 神経原線織変化 / タウ / アルファ・シヌクレイン / アルツハイマー型痴呆 / レビー小体病 / シンヌクレイン / ドネペジル / 視覚認知障害 / アルツハイマー病 / 痴呆を伴うパーキンソン病 / レビー小体型痴呆 / interacting molecule / GST fusion protein / synuclein / synphilin / diffuse Lewy body disease / Parkinson's disease / Lewy小体 / ユビキリン / びまん性レビー小体病 / 相互作用分子 / GST隔合タンパク / シヌクレイン / シンフィリン / レビィ小体 / び漫性レビィ小体病 / α-シヌクレイン / Clinicopathology / Epidemiology / Demented disorders / Presenile onset / 臨床病理学 / 疫学 / 痴呆性疾患 / 初老期 Less
  • Research Projects

    (7 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (10 People)
  •  Clinical and Basic Research of Dementia with Lewy bodiesPrincipal Investigator

    • Principal Investigator
      MIURA Satashi, 小阪 憲司
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Yokohama City University
  •  Identification of interacting molecules with α-synuclein and of their function in the pathology of neurodegenerative diseases

    • Principal Investigator
      NAKAI Toshiki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Yokohama City University
  •  Clinical, pathological, biochemical and molecular biological research on dementia with Lewy bodiesPrincipal Investigator

    • Principal Investigator
      KOSAKA Kenji
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Yokohama City University
  •  A study on the pathophysiology of diffuse Lewy body diseasePrincipal Investigator

    • Principal Investigator
      KOSAKA Kenji
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Yokohama City University
  •  Epidemiologic and clinicopathologic study of presenile demented disorders

    • Principal Investigator
      ISEKI Eizo
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Yokohama City University
  •  A comparative study of diffuse Lewy body disease and Alzheimer type dementiaPrincipal Investigator

    • Principal Investigator
      KOSAKA Kenji
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Yokohama City University
  •  Biochemical, Immunohistochemical and Neuropathological Study of Gangliosides in Alzheimer-Type Dementia BrainsPrincipal Investigator

    • Principal Investigator
      KOSAKA Kenji
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Psychiatric Research Institute of Tokyo

All 2005 2004 2003 2002

All Journal Article

  • [Journal Article] レビー小体型痴呆の概念と臨床像2005

    • Author(s)
      小阪憲司
    • Journal Title

      Cognition Dementia 4

      Pages: 9-14

    • NAID

      40015225970

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] レビー小体型痴呆と神経原線維変化型痴呆2004

    • Author(s)
      小阪憲司
    • Journal Title

      老年医学 42

      Pages: 1240-1248

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] レビー小体型痴呆の治療2004

    • Author(s)
      小阪憲司
    • Journal Title

      Brain Medical 16

      Pages: 48-52

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] レビー小体型痴呆の概念と臨床像2004

    • Author(s)
      小阪憲司
    • Journal Title

      Cognition Dementia 4(1)

      Pages: 9-14

    • NAID

      40015225970

    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] パーキンソン病の精神症状への対応2004

    • Author(s)
      小阪憲司
    • Journal Title

      診断と治療 92(5)

      Pages: 827-830

    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Serum ghrelin concentrations in patients receiving olanzapine or rispedorine2004

    • Author(s)
      Togo, T., Hasegawa, K., Miura, S., Hosogima, H., Kojima, K., Shoji, M., Kase, A., Uchikado, H., Iseki, E., Kosaka, K.
    • Journal Title

      Psychophanmacology 172

      Pages: 230-232

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] びまん性Lewy小体病2004

    • Author(s)
      小阪憲司
    • Journal Title

      脳の科学 増刊号

      Pages: 249-253

    • NAID

      10012755461

    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] レビー小体型痴呆と神経原線維変化型痴呆2004

    • Author(s)
      小阪憲司
    • Journal Title

      老年医学 42(9)

      Pages: 967-972

    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] びまん性レビー小体病2004

    • Author(s)
      小阪憲司
    • Journal Title

      Clin Neurosci 22(11)

      Pages: 1444-1445

    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] びまん性レビー小体病の最近の話題2004

    • Author(s)
      小阪憲司
    • Journal Title

      老年期痴呆研究会誌 13

      Pages: 99-100

    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] びまん性レビー小体病(DLBD)2004

    • Author(s)
      小阪憲司
    • Journal Title

      Ann Review 神経2004

      Pages: 84-90

    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease2004

    • Author(s)
      Marui, W., Iseki, E., Kato, M., Akatsu, H., Kosaka, K.
    • Journal Title

      Acta Neuropathol 108

      Pages: 121-128

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Alzheimer型痴呆とLewy小体型痴呆2004

    • Author(s)
      小阪憲司
    • Journal Title

      日本臨床 増刊号4 62

      Pages: 159-163

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] レビー小体型痴呆の治療2004

    • Author(s)
      小阪憲司
    • Journal Title

      Brain Medical 16(1)

      Pages: 48-52

    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] びまん性Lewy小体病2004

    • Author(s)
      小阪憲司
    • Journal Title

      脳の科学 増刊号 249

      Pages: 249-253

    • NAID

      10012755461

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Alzheimer型痴呆とLewy小体型痴呆2004

    • Author(s)
      小阪憲司
    • Journal Title

      日本臨床 62増刊号4

      Pages: 159-163

    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies2003

    • Author(s)
      Katsuse, O., Iseki, E., Marui, W., Kosaka, K.
    • Journal Title

      J. Neurol.Sci. 211

      Pages: 29-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Dementia with Lewy bodies from the perspective of tauropathy2003

    • Author(s)
      Iseki, E., Togo, T., Suzuki, K., Katsuse, O., Marui, W., de Silva, R., Lee, A., Yamamoto, T., Kosaka, K.
    • Journal Title

      Acta Neuropathol. 105

      Pages: 265-270

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Degeneration of tyrosine hydroxylase-immunoreactive neurons in the cerebral cortex and hippocampus of patients with dementia with Lewy bodies2003

    • Author(s)
      Murai, W., Iseki, E., Kato, M., Kosaka, K.
    • Journal Title

      Neurosci. Lett. 340

      Pages: 185-188

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Immunohistochemical study of the expression of cytokines and nitric oxide synthases in brains of patients with Lewy bodies2003

    • Author(s)
      Katsuse, O., Iseki, E., Kosaka, K.
    • Journal Title

      Neuropathology 23

      Pages: 9-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies2003

    • Author(s)
      Nunomura, A., Chiba, S., Kosaka, K., Takeda, A., Castellani, R.J., Smith, M., Perry, G.
    • Journal Title

      Clin. Neurosci. Neuropatholo. 13

      Pages: 2035-2039

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Cognitive conditions of pathologically confirmed dementia with Lewy bodies and Parkinson's disease with dementia2003

    • Author(s)
      Horimoto, Y., Matsumoto, M., Nakagawa, H., Yoasa, H., Morishima, M., Akatsu, H., Ikari, H., Yamamoto, Y., Kosaka, K.
    • Journal Title

      J. Neurol. 250

      Pages: 530-533

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies2002

    • Author(s)
      Marui, W., Iseki, E., Nakai, T., Miura, S., Kato, M., Ueda, K., Kosaka, K.
    • Journal Title

      Neurol. Sci. 195

      Pages: 153-159

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] レビー小体型痴呆の診断と治療2002

    • Author(s)
      小阪憲司
    • Journal Title

      臨床と研究 49

      Pages: 65-70

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Relationship in the formation process between neurofibrillary tangles and Lewy bodies in the hippocampus of dementia with Lewy bodies brains2002

    • Author(s)
      Iseki, E., Takayama, N., Marui, W., Ueda, K., Kosaka, K.
    • Journal Title

      J. Neurol. Sci. 195

      Pages: 85-91

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Immunohistochemical study of synphilin 1 in brains of patients with dementia with Lewy bodies-Synphilin 1 is non-specifically implicated in the formation of different neuronal cytoskeletal inclusions2002

    • Author(s)
      Iseki, E., Takayama, N., Furukawa, Y., Marui, W., Nakai, T., Miura, S., Ueda, K., Kosaka, K.
    • Journal Title

      Neurosci. Lett. 326

      Pages: 211-215

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] レビー小体型痴呆2002

    • Author(s)
      小阪憲司
    • Journal Title

      総合臨床 51

      Pages: 100-104

    • NAID

      10016928720

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • [Journal Article] Psychiatric symptoms typical of patients with dementia with Lewy bodies-similarity to those of levodova-induced psychosis2002

    • Author(s)
      Iseki, E., Marui, W., Nihashi, N., Kosaka, K.
    • Journal Title

      Acta Neuropsychiat 14

      Pages: 237-241

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370293
  • 1.  ISEKI Eizo (30203061)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 10 results
  • 2.  MIURA Megumi (60157427)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 3.  ODAWARA Toshinari (00244426)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  ONISHI Hideki (30275028)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  SUZUKI Yasuo (00046278)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  IWAMOTO Norihiko (60211067)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  GOTOU Kenichi (00254201)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  NAKAI Toshiki (20270712)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  山田 芳輝 (70220415)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  NISHINAKA Tetsuya
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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