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OKAWARA Tadashi  大川原 正

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OOKAWARA Tadashi  大川原 正

OKAWARA Takashi  大川原 正

大川原 正  オオカワラ タダシ

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Researcher Number 60040325
Other IDs
Affiliation (based on the past Project Information) *help 2015: 熊本科学保健大学, 保健科学部, 教授
2010: 熊本保健科学大学, 保健科学部, 教授
2006 – 2008: 熊本保健科学大学, 保健科学部, 教授
1997 – 2002: 熊本大学, 薬学部, 助教授
2001: Kumamoto University, Graduate School of Pharmaceutical Sciences, Associate Professor, 大学院・薬学研究科, 助教授
1995: 熊本大学, 薬学部, 助教授
Review Section/Research Field
Principal Investigator
医薬分子機能学 / Drug development chemistry
Except Principal Investigator
Chemical biology / 医薬分子機能学 / Drug development chemistry / Chemical pharmacy
Keywords
Principal Investigator
hetero ring / docking / anti-cancer drug / structure optimization / Galloyl group / allosteric inhinition / mutation / Moleculat Targeted Drug / 抗がん剤 / 異変 … More / ヘテロ環 / ドッキング / 抗がん薬 / 構造最適化 / ガロイル基 / アロステリック阻害 / 変異 / 分子標的薬 / O-sulfonate / aliphatic acid with a long chain / Topostatin / Cyclic depsi peptide / Topoisomerase Inhibitory / Anti-Cancer Agent / トポイソメラーゼ / O-スルフォネート / 長鎖脂肪酸 / トポスタチン / 環状デプシペプチド / トポイソメラーゼ阻害 / 抗癌剤 / protein synthetase inhibitor / acyclic dinucleoside / interferon / bis-1,3-dioxolane / adenyl phosphonate / 1,3-dioxolane / nuclease / 2'-5' oligoadenylate / 2'-5'-オリゴアデニレート / ジヌクレオシド / ジオキソラン / 2',5'-オリゴアデニレート / 蛋白質合成阻害物質 / 非環状ジヌクレオシド / インターフェロン / ビス-1,3-ジオキソラン / アデニルフォスフォノエート / 1,3-ジオキソラン / 核酸分解酵素 / 2'-5'オリゴアデニレート … More
Except Principal Investigator
ROS / JNK / NFkB / MIF / レスベラトロール / Ras protein / oncogene / farnesyltransferase / man-made chelator / Ras蛋白質 / 癌遺伝子 / ファルネシルトランスフェラーゼ / 人工配位子 / 抗酸化 / 阻害様式 / 薬学 / 酵素 / 癌 / 酵素阻害 / トポイソメラーゼ / 抗がん薬 / 生物活性物質 / グリシナ-ル誘導体 / ジアサエストロンサルフェート / ジアサエストラジオール / ジアザエストロン / エストロンサルフェート / 抗乳癌剤 / ステロイドサルファターゼ阻害剤 Less
  • Research Projects

    (7 results)
  • Research Products

    (4 results)
  • Co-Researchers

    (10 People)
  •  Mechanism of anti-proliferative effect of resveratrol derivatives on cancer cells

    • Principal Investigator
      FUJITA Yoshihiko
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical biology
    • Research Institution
      Kinki University
  •  Development of low toxicity topoisomerase inhibitor (anticancer medicine) with treatment and protective efficacy

    • Principal Investigator
      SUZUKI Keitarou
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Yokohama College of Pharmacy
  •  Studies on Novel Anti-Cancer Drugs binding to Allosteric sitePrincipal Investigator

    • Principal Investigator
      OKAWARA Takashi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kumamoto Health Science University
  •  Structure-Activity-Relationship of Topostatin Derivatives with Cyclic Peptide as Topoisomerase InhibitorPrincipal Investigator

    • Principal Investigator
      OKAWARA Tadashi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kumamoto University
  •  Molecular Design of Ras Farnesyltransferase Inhibitors

    • Principal Investigator
      OTSUKA Masami
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kumamoto University
  •  Simple Preparation of Acyclic Adenylate and Its Inhibitory Activity of Protein SynthetasePrincipal Investigator

    • Principal Investigator
      OKAWARA Tadashi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      Faculty of Pharmaceutical Sciences, Kumamoto University
  •  ステロイドサルファターゼ阻害剤-アザエストロンの合成と抗乳癌剤への応用

    • Principal Investigator
      古川 潮
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kumamoto University

All 2010 2008 Other

All Journal Article Presentation

  • [Journal Article] Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships.2008

    • Author(s)
      Hosono T., Yokomizo K., Okawara T., Hamasaki A., Okamoto Y., Otsuka M., Mukai R., Suzuki K.
    • Journal Title

      Bioorg.Med.Chem.Lett. 18

      Pages: 371-374

    • Data Source
      KAKENHI-PROJECT-20590109
  • [Presentation] 低毒性トポイソメラーゼ阻害抗がん薬の開発2010

    • Author(s)
      野口貴史,細野哲司,大川原正,大塚雅巳,鈴木啓太郎
    • Organizer
      第54回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-20590109
  • [Presentation] 低毒性トポイソメラーゼ阻害抗がん薬の開発2010

    • Author(s)
      細野哲司,大川原正,大塚雅巳,鈴木啓太郎
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-20590109
  • [Presentation] Inhibiting Topoisomerase with di- and tri-GalloylCompounds by Allosteric Effect

    • Author(s)
      Tadashi Okawara, Keitarou Suzuki, Mitsugu Takanami, Masami Otsuka
    • Organizer
      27th Medicinal Chemistry Symposium
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590099
  • 1.  SUZUKI Keitarou (10154535)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 2.  HOSONO Tetsuji (20450554)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 3.  OMATA Yoshiaki (20268840)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  OTSUKA Masami (40126008)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  OKAMOTO Yoshinari (20194409)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  YAMASAKI Tetsuo (60182474)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  IMOTO Masaya (60213253)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  UMEZAWA Kazuo (70114402)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  FUJITA Yoshihiko (80192730)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  古川 潮 (20040305)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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