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OKAWARA Tadashi
大川原 正
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Alternative Names
OOKAWARA Tadashi 大川原 正
OKAWARA Takashi 大川原 正
大川原 正 オオカワラ タダシ
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Researcher Number
60040325
Affiliation (based on the past Project Information)
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2015: 熊本科学保健大学, 保健科学部, 教授
2010: 熊本保健科学大学, 保健科学部, 教授
2006 – 2008: 熊本保健科学大学, 保健科学部, 教授
1997 – 2002: 熊本大学, 薬学部, 助教授
2001: Kumamoto University, Graduate School of Pharmaceutical Sciences, Associate Professor, 大学院・薬学研究科, 助教授
1995: 熊本大学, 薬学部, 助教授
Review Section/Research Field
Principal Investigator
医薬分子機能学
/
Drug development chemistry
Except Principal Investigator
Chemical pharmacy
/
Drug development chemistry
/
医薬分子機能学
/
Chemical biology
Keywords
Principal Investigator
2'-5'オリゴアデニレート / 核酸分解酵素 / 1,3-ジオキソラン / アデニルフォスフォノエート / ビス-1,3-ジオキソラン / インターフェロン / 非環状ジヌクレオシド / 蛋白質合成阻害物質 / 2',5'-オリゴアデニレート / ジオキソラン
…
More
/ ジヌクレオシド / 2'-5'-オリゴアデニレート / 2'-5' oligoadenylate / nuclease / 1,3-dioxolane / adenyl phosphonate / bis-1,3-dioxolane / interferon / acyclic dinucleoside / protein synthetase inhibitor / 抗癌剤 / トポイソメラーゼ阻害 / 環状デプシペプチド / トポスタチン / 長鎖脂肪酸 / O-スルフォネート / トポイソメラーゼ / Anti-Cancer Agent / Topoisomerase Inhibitory / Cyclic depsi peptide / Topostatin / aliphatic acid with a long chain / O-sulfonate / 分子標的薬 / 変異 / アロステリック阻害 / ガロイル基 / 構造最適化 / 抗がん薬 / ドッキング / ヘテロ環 / 異変 / 抗がん剤 / Moleculat Targeted Drug / mutation / allosteric inhinition / Galloyl group / structure optimization / anti-cancer drug / docking / hetero ring
…
More
Except Principal Investigator
ステロイドサルファターゼ阻害剤 / 抗乳癌剤 / エストロンサルフェート / ジアザエストロン / ジアサエストラジオール / ジアサエストロンサルフェート / グリシナ-ル誘導体 / 生物活性物質 / 抗がん薬 / トポイソメラーゼ / 酵素阻害 / 癌 / 酵素 / 薬学 / 阻害様式 / 抗酸化 / 人工配位子 / ファルネシルトランスフェラーゼ / 癌遺伝子 / Ras蛋白質 / man-made chelator / farnesyltransferase / oncogene / Ras protein / レスベラトロール / MIF / NFkB / JNK / ROS
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Research Projects
(
7
results)
Research Products
(
4
results)
Co-Researchers
(
10
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Mechanism of anti-proliferative effect of resveratrol derivatives on cancer cells
Principal Investigator
FUJITA Yoshihiko
Project Period (FY)
2013 – 2015
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Chemical biology
Research Institution
Kinki University
Development of low toxicity topoisomerase inhibitor (anticancer medicine) with treatment and protective efficacy
Principal Investigator
SUZUKI Keitarou
Project Period (FY)
2008 – 2010
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Drug development chemistry
Research Institution
Yokohama College of Pharmacy
Studies on Novel Anti-Cancer Drugs binding to Allosteric site
Principal Investigator
Principal Investigator
OKAWARA Takashi
Project Period (FY)
2006 – 2007
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Drug development chemistry
Research Institution
Kumamoto Health Science University
Structure-Activity-Relationship of Topostatin Derivatives with Cyclic Peptide as Topoisomerase Inhibitor
Principal Investigator
Principal Investigator
OKAWARA Tadashi
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
医薬分子機能学
Research Institution
Kumamoto University
Molecular Design of Ras Farnesyltransferase Inhibitors
Principal Investigator
OTSUKA Masami
Project Period (FY)
1999 – 2001
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
医薬分子機能学
Research Institution
Kumamoto University
Simple Preparation of Acyclic Adenylate and Its Inhibitory Activity of Protein Synthetase
Principal Investigator
Principal Investigator
OKAWARA Tadashi
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
医薬分子機能学
Research Institution
Faculty of Pharmaceutical Sciences, Kumamoto University
ステロイドサルファターゼ阻害剤-アザエストロンの合成と抗乳癌剤への応用
Principal Investigator
古川 潮
Project Period (FY)
1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Chemical pharmacy
Research Institution
Kumamoto University
All
2010
2008
Other
All
Journal Article
Presentation
[Journal Article] Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships.
2008
Author(s)
Hosono T., Yokomizo K., Okawara T., Hamasaki A., Okamoto Y., Otsuka M., Mukai R., Suzuki K.
Journal Title
Bioorg.Med.Chem.Lett. 18
Pages
: 371-374
Data Source
KAKENHI-PROJECT-20590109
[Presentation] 低毒性トポイソメラーゼ阻害抗がん薬の開発
2010
Author(s)
野口貴史,細野哲司,大川原正,大塚雅巳,鈴木啓太郎
Organizer
第54回日本薬学会関東支部大会
Place of Presentation
東京
Data Source
KAKENHI-PROJECT-20590109
[Presentation] 低毒性トポイソメラーゼ阻害抗がん薬の開発
2010
Author(s)
細野哲司,大川原正,大塚雅巳,鈴木啓太郎
Organizer
日本薬学会第130年会
Place of Presentation
岡山
Data Source
KAKENHI-PROJECT-20590109
[Presentation] Inhibiting Topoisomerase with di- and tri-GalloylCompounds by Allosteric Effect
Author(s)
Tadashi Okawara, Keitarou Suzuki, Mitsugu Takanami, Masami Otsuka
Organizer
27th Medicinal Chemistry Symposium
Place of Presentation
Osaka
Description
「研究成果報告書概要(欧文)」より
Data Source
KAKENHI-PROJECT-18590099
# of Projects (Dsc)
# of Projects (Asc)
1.
SUZUKI Keitarou
(10154535)
# of Collaborated Projects:
3 results
# of Collaborated Products:
4 results
2.
HOSONO Tetsuji
(20450554)
# of Collaborated Projects:
1 results
# of Collaborated Products:
3 results
3.
OMATA Yoshiaki
(20268840)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
4.
OTSUKA Masami
(40126008)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
5.
OKAMOTO Yoshinari
(20194409)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
6.
YAMASAKI Tetsuo
(60182474)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
7.
IMOTO Masaya
(60213253)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
8.
UMEZAWA Kazuo
(70114402)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
9.
FUJITA Yoshihiko
(80192730)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
10.
古川 潮
(20040305)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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