OKADA Yoshio 岡田芳男

… Alternative Names

岡田芳男オカダヨシオ

Less

Researcher Number	60068236
Other IDs
External Links
Affiliation (Current)	2025: 神戸学院大学, その他部局等, 名誉教授
Affiliation (based on the past Project Information) *help	2009: 神戸学院大学, 食品薬品総合科学研究科, 教授 2007 – 2008: 神戸学院大学, 食品薬品総合研究科, 教授 1999 – 2001: 神戸学院大学, 薬学部, 教授 1996 – 1997: 神戸学院大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator 医薬分子機能学 Except Principal Investigator 医薬分子機能学 / Drug development chemistry
Keywords	Principal Investigator μ-opioid receptor agoniat / dimethyltyrosine / diamine derivartives / endomorphine derivatives / pyrazinone derivatives / opioid mimetics / 二機能性リガンド / δ-オピオイドレセプターアンタゴニスト / エンドモルーフィン誘導体 / オピオイドミナティクス … More / 皮下投与 / 鎮痛薬 / μ-オピオイドレセプターアゴニスト / ジメチルチロシン / ジアミン誘導体 / エンドモルフィン誘導体 / ピラジノン誘導体 / オピオイドミメティクス … More Except Principal Investigator fibrinolysis / coagulation / bifunctional inhibitor / 線溶系 / 凝固系 / 二機能性阻害剤 / 分子設計 / コンフォメーション解析 / 酵素安定性 / オピオイド受容体 / エンドモルフィン Less

Design of agonists and antagonists for opioid receptors based on the structures of endomorphins
- Principal Investigator
  
  TSUDA Yuko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
Design and synthesis of μ-selective opioidomimetic peptidesPrincipal Investigator
- Principal Investigator
  
  OKADA Yoshio
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kobe Gakuin University
Design of Bifunctional Inhibitors for Enzymes in Coagulation-Fibrinolytic System
- Principal Investigator
  
  TSUDA Yuko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kobe Gakuin University

All 2010 2008 2007

All Journal Article Presentation Patent

[Journal Article] Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties2008
- Author(s)
  Miyazaki, A., Tsuda, Y., Fukushima, S., Yokoi, T., Vantus, T., Bokonyi, G., Szabo, E., Horvath, A., Keri, G., Okada Y
- Journal Title
  
  J. Med. Chem 51
  
  Pages: 5121-5124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Structural studies of [2, 6-dimethyl-L-tyrosine1] endomorphin-2 analogues containing proline mimics2008
- Author(s)
  Tsuda, Y., Miyazaki, A., Yamada, T., Isozaki, K., Shimohigashi, Y., Ambo, A., Sasaki, Y., Minoura, K., In, Y., Ishida, T., Okada, Y
- Journal Title
  
  Peptide Science 2008
  
  Pages: 227-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] New cyclic somatostatin analogues containing a pyrazinone ring: Importance of Tyr for antiproliferative activity2008
- Author(s)
  Miyazaki, A., Tsuda, Y., Fukushima, S., Yokoi, T., Vantus, T., Bokonyi, G., Szabo, E., Horvath, A., Keri, G., Okada Y
- Journal Title
  
  Bioorg. Med. Chem. Lett 18
  
  Pages: 6199-6201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Synthesis of endomorphin-2 analogues containing piperidinecarboxylic acid (Pip) and 2-azetidinecarboxylic acid (Aze)2008
- Author(s)
  Tsuda, Y., Miyazaki, A., Yamada, T., Isozaki, K., Shimohigashi, Y., Ambo, A., Sasaki, Y., Okada, Y
- Journal Title
  
  Peptide Science 2007
  
  Pages: 267-268
- NAID
  10021906993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Synthesis and biological profiles of endomorphin-2 analogues containing a conformationally constrained moiety2007
- Author(s)
  suda, Y., Kawakami, T., Fujita, Y., Yamada, T., Isozaki, K., Shimohigashi, Y., Lazarus, L.H., Okada, Y
- Journal Title
  
  Peptides 2006
  
  Pages: 128-129
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Synthesis and binding activities for the opioid receptors of endomorphin and morphiceptin analogs containing conformationally constrained 1-aminocyclolakane-1-carboxylic acids2007
- Author(s)
  Yamada, T., Hakogi, S., Iino, M., Murashima, T., Miyazawa, T., Tsuda, Y., Kawakami, T., Okada, Y., Isozaki, K., Shimohigashi, T
- Journal Title
  
  Peptides 2006
  
  Pages: 668-669
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Synthesis of opioidmimetics, 3-[H-Dmt-NH(CH2)(m)]-6-[H-Dmt-NH(CH2)(n)]-2(1H)-pyrazinon es, and studies on structure-activity relationships2007
- Author(s)
  Shiotani, K., Miyazaki A., Li, T., Tsuda, Y., Yokoi, T., Ambo, A., Sasaki, Y., Bryant, S.D., Jinsmaa, Y., Lazarus, L.H., Okada, Y
- Journal Title
  
  Med. Chem 3
  
  Pages: 583-598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Design and synthesis of opioidmimetics containing 2', 6'-dimethyl-L-tyrosine and a pyrazinone-ring platform2007
- Author(s)
  Shiotani, K., Li, T., Miyazaki, A., Tsuda, Y., Yokoi, T., Ambo, A., Sasaki, Y., Bryant, S.D., Lazarus, L.H., Okada, Y
- Journal Title
  
  Chem. Lett 17
  
  Pages: 5768-5771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] Bifunctional [2', 6'-dimethyl-Ltyrosine1] endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/deltaantagonist and dual mu-agonist/ delta-agonist opioid ligands2007
- Author(s)
  Li, T., Shiotani, K., Miyazaki, A., Tsuda, Y., Ambo, A., Sasaki, Y., Jinsmaa, Y., Marczak, E., Bryant, S.D., Lazarus, L.H., Okada, Y
- Journal Title
  
  J. Med. Chem 50
  
  Pages: 2753-2766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Journal Article] [N-Allyl-Dmt1] Endomorphins are {micro}-opioid receptor antagonists lacking inverse agonist properties2007
- Author(s)
  Marczak, E.D., Jinsmaa, Y., Li, T., Bryant, S.D., Tsuda, Y., Okada, Y., Lazarus, L. H
- Journal Title
  
  J. Pharmacol. Exp. Ther 323
  
  Pages: 374-380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590112
[Patent] 新規なオピオイド誘導体2010
- Inventor(s)
  岡田芳男, 津田裕子, 横井利夫
- Industrial Property Rights Holder
  帝国製薬株式会社
- Acquisition Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] プロリンミミックを含む[2', 6'-dimethyl-L-tyrosine1] endomorphin 2類似体の酵素安定性とコンフォメーションの検討2010
- Author(s)
  津田裕子, 安保明博, 佐々木友亮, 箕浦克彦, 尹康子, 石田寿昌, 岡田芳男
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] ynthesis and biological activities of endomorphin-2 analogues containing Pro mimics2008
- Author(s)
  津田裕子, 宮崎杏奈, 山田隆巳, 磯崎要, 下東康幸, 安保明博, 佐々木有亮, 箕浦克彦, 尹康子、石田寿昌、岡田芳男
- Organizer
  第30回European Peptide Symposium
- Place of Presentation
  Helsinki, Finland
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] プロリンミミックを含む[2', 6'-dimethyl-L-tyrosine1] endomorphin-2類似体のコンフォメーション解析2008
- Author(s)
  津田裕子, 宮崎杏奈, 山田隆巳, 磯崎要, 下東康幸, 安保明博, 佐々木有亮, 箕浦克彦, 尹康子, 石田寿昌、岡田芳男
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590112
[Presentation] 芳男:ピペリジンカルボン酸またはアゼチジンカルボン酸を含むエンドモルフィンー2類似体の合成2007
- Author(s)
  津田裕子, 宮崎杏奈, 山田隆巳, 磯崎要, 下東康幸, 安保明博, 佐々木有亮, 岡田芳男
- Organizer
  第44回ペプチド討論会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19590112

1. TSUDA Yuko (10098478)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
2. YUKOI Toshio (50122255)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. YAMAMOTO Junichiro (60068252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OKADA Yoshio 岡田 芳男

岡田 芳男 オカダ ヨシオ

Research Projects

Research Products

Co-Researchers

Design of agonists and antagonists for opioid receptors based on the structures of endomorphins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design and synthesis of μ-selective opioidomimetic peptidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design of Bifunctional Inhibitors for Enzymes in Coagulation-Fibrinolytic System

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties2008

Author(s)

Journal Title

Data Source

[Journal Article] Structural studies of [2, 6-dimethyl-L-tyrosine1] endomorphin-2 analogues containing proline mimics2008

Author(s)

Journal Title

Data Source

[Journal Article] New cyclic somatostatin analogues containing a pyrazinone ring: Importance of Tyr for antiproliferative activity2008

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of endomorphin-2 analogues containing piperidinecarboxylic acid (Pip) and 2-azetidinecarboxylic acid (Aze)2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Synthesis and biological profiles of endomorphin-2 analogues containing a conformationally constrained moiety2007

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis and binding activities for the opioid receptors of endomorphin and morphiceptin analogs containing conformationally constrained 1-aminocyclolakane-1-carboxylic acids2007

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of opioidmimetics, 3-[H-Dmt-NH(CH2)(m)]-6-[H-Dmt-NH(CH2)(n)]-2(1H)-pyrazinon es, and studies on structure-activity relationships2007

Author(s)

Journal Title

Data Source

[Journal Article] Design and synthesis of opioidmimetics containing 2', 6'-dimethyl-L-tyrosine and a pyrazinone-ring platform2007

Author(s)

Journal Title

Data Source

[Journal Article] Bifunctional [2', 6'-dimethyl-Ltyrosine1] endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/deltaantagonist and dual mu-agonist/ delta-agonist opioid ligands2007

Author(s)

Journal Title

Data Source

[Journal Article] [N-Allyl-Dmt1] Endomorphins are {micro}-opioid receptor antagonists lacking inverse agonist properties2007

Author(s)

Journal Title

Data Source

[Patent] 新規なオピオイド誘導体2010

Inventor(s)

Industrial Property Rights Holder

Acquisition Date

Data Source

[Presentation] プロリンミミックを含む[2', 6'-dimethyl-L-tyrosine1] endomorphin 2類似体の酵素安定性とコンフォメーションの検討2010

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] ynthesis and biological activities of endomorphin-2 analogues containing Pro mimics2008

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] プロリンミミックを含む[2', 6'-dimethyl-L-tyrosine1] endomorphin-2類似体のコンフォメーション解析2008

OKADA Yoshio 岡田芳男

岡田芳男オカダヨシオ