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OKADA Yoshio  岡田 芳男

ORCIDConnect your ORCID iD *help
… Alternative Names

岡田 芳男  オカダ ヨシオ

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Researcher Number 60068236
Other IDs
External Links
Affiliation (Current) 2025: 神戸学院大学, その他部局等, 名誉教授
Affiliation (based on the past Project Information) *help 2009: 神戸学院大学, 食品薬品総合科学研究科, 教授
2007 – 2008: 神戸学院大学, 食品薬品総合研究科, 教授
1999 – 2001: 神戸学院大学, 薬学部, 教授
1996 – 1997: 神戸学院大学, 薬学部, 教授
Review Section/Research Field
Principal Investigator
医薬分子機能学
Except Principal Investigator
医薬分子機能学 / Drug development chemistry
Keywords
Principal Investigator
μ-opioid receptor agoniat / dimethyltyrosine / diamine derivartives / endomorphine derivatives / pyrazinone derivatives / opioid mimetics / 二機能性リガンド / δ-オピオイドレセプターアンタゴニスト / エンドモルーフィン誘導体 / オピオイドミナティクス … More / 皮下投与 / 鎮痛薬 / μ-オピオイドレセプターアゴニスト / ジメチルチロシン / ジアミン誘導体 / エンドモルフィン誘導体 / ピラジノン誘導体 / オピオイドミメティクス … More
Except Principal Investigator
fibrinolysis / coagulation / bifunctional inhibitor / 線溶系 / 凝固系 / 二機能性阻害剤 / 分子設計 / コンフォメーション解析 / 酵素安定性 / オピオイド受容体 / エンドモルフィン Less
  • Research Projects

    (3 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (3 People)
  •  Design of agonists and antagonists for opioid receptors based on the structures of endomorphins

    • Principal Investigator
      TSUDA Yuko
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kobe Gakuin University
  •  Design and synthesis of μ-selective opioidomimetic peptidesPrincipal Investigator

    • Principal Investigator
      OKADA Yoshio
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kobe Gakuin University
  •  Design of Bifunctional Inhibitors for Enzymes in Coagulation-Fibrinolytic System

    • Principal Investigator
      TSUDA Yuko
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kobe Gakuin University

All 2010 2008 2007

All Journal Article Presentation Patent

  • [Journal Article] Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties2008

    • Author(s)
      Miyazaki, A., Tsuda, Y., Fukushima, S., Yokoi, T., Vantus, T., Bokonyi, G., Szabo, E., Horvath, A., Keri, G., Okada Y
    • Journal Title

      J. Med. Chem 51

      Pages: 5121-5124

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590112
  • [Journal Article] Structural studies of [2, 6-dimethyl-L-tyrosine1] endomorphin-2 analogues containing proline mimics2008

    • Author(s)
      Tsuda, Y., Miyazaki, A., Yamada, T., Isozaki, K., Shimohigashi, Y., Ambo, A., Sasaki, Y., Minoura, K., In, Y., Ishida, T., Okada, Y
    • Journal Title

      Peptide Science 2008

      Pages: 227-228

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590112
  • [Journal Article] New cyclic somatostatin analogues containing a pyrazinone ring: Importance of Tyr for antiproliferative activity2008

    • Author(s)
      Miyazaki, A., Tsuda, Y., Fukushima, S., Yokoi, T., Vantus, T., Bokonyi, G., Szabo, E., Horvath, A., Keri, G., Okada Y
    • Journal Title

      Bioorg. Med. Chem. Lett 18

      Pages: 6199-6201

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590112
  • [Journal Article] Synthesis of endomorphin-2 analogues containing piperidinecarboxylic acid (Pip) and 2-azetidinecarboxylic acid (Aze)2008

    • Author(s)
      Tsuda, Y., Miyazaki, A., Yamada, T., Isozaki, K., Shimohigashi, Y., Ambo, A., Sasaki, Y., Okada, Y
    • Journal Title

      Peptide Science 2007

      Pages: 267-268

    • NAID

      10021906993

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590112
  • [Journal Article] Synthesis and biological profiles of endomorphin-2 analogues containing a conformationally constrained moiety2007

    • Author(s)
      suda, Y., Kawakami, T., Fujita, Y., Yamada, T., Isozaki, K., Shimohigashi, Y., Lazarus, L.H., Okada, Y
    • Journal Title

      Peptides 2006

      Pages: 128-129

    • Data Source
      KAKENHI-PROJECT-19590112
  • [Journal Article] Synthesis and binding activities for the opioid receptors of endomorphin and morphiceptin analogs containing conformationally constrained 1-aminocyclolakane-1-carboxylic acids2007

    • Author(s)
      Yamada, T., Hakogi, S., Iino, M., Murashima, T., Miyazawa, T., Tsuda, Y., Kawakami, T., Okada, Y., Isozaki, K., Shimohigashi, T
    • Journal Title

      Peptides 2006

      Pages: 668-669

    • Data Source
      KAKENHI-PROJECT-19590112
  • [Journal Article] Synthesis of opioidmimetics, 3-[H-Dmt-NH(CH2)(m)]-6-[H-Dmt-NH(CH2)(n)]-2(1H)-pyrazinon es, and studies on structure-activity relationships2007

    • Author(s)
      Shiotani, K., Miyazaki A., Li, T., Tsuda, Y., Yokoi, T., Ambo, A., Sasaki, Y., Bryant, S.D., Jinsmaa, Y., Lazarus, L.H., Okada, Y
    • Journal Title

      Med. Chem 3

      Pages: 583-598

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590112
  • [Journal Article] Design and synthesis of opioidmimetics containing 2', 6'-dimethyl-L-tyrosine and a pyrazinone-ring platform2007

    • Author(s)
      Shiotani, K., Li, T., Miyazaki, A., Tsuda, Y., Yokoi, T., Ambo, A., Sasaki, Y., Bryant, S.D., Lazarus, L.H., Okada, Y
    • Journal Title

      Chem. Lett 17

      Pages: 5768-5771

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590112
  • [Journal Article] Bifunctional [2', 6'-dimethyl-Ltyrosine1] endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/deltaantagonist and dual mu-agonist/ delta-agonist opioid ligands2007

    • Author(s)
      Li, T., Shiotani, K., Miyazaki, A., Tsuda, Y., Ambo, A., Sasaki, Y., Jinsmaa, Y., Marczak, E., Bryant, S.D., Lazarus, L.H., Okada, Y
    • Journal Title

      J. Med. Chem 50

      Pages: 2753-2766

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590112
  • [Journal Article] [N-Allyl-Dmt1] Endomorphins are {micro}-opioid receptor antagonists lacking inverse agonist properties2007

    • Author(s)
      Marczak, E.D., Jinsmaa, Y., Li, T., Bryant, S.D., Tsuda, Y., Okada, Y., Lazarus, L. H
    • Journal Title

      J. Pharmacol. Exp. Ther 323

      Pages: 374-380

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590112
  • [Patent] 新規なオピオイド誘導体2010

    • Inventor(s)
      岡田芳男, 津田裕子, 横井利夫
    • Industrial Property Rights Holder
      帝国製薬株式会社
    • Acquisition Date
      2010-03-05
    • Data Source
      KAKENHI-PROJECT-19590112
  • [Presentation] プロリンミミックを含む[2', 6'-dimethyl-L-tyrosine1] endomorphin 2類似体の酵素安定性とコンフォメーションの検討2010

    • Author(s)
      津田裕子, 安保明博, 佐々木友亮, 箕浦克彦, 尹康子, 石田寿昌, 岡田芳男
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-19590112
  • [Presentation] ynthesis and biological activities of endomorphin-2 analogues containing Pro mimics2008

    • Author(s)
      津田裕子, 宮崎杏奈, 山田隆巳, 磯崎要, 下東康幸, 安保明博, 佐々木有亮, 箕浦克彦, 尹康子、石田寿昌、岡田芳男
    • Organizer
      第30回European Peptide Symposium
    • Place of Presentation
      Helsinki, Finland
    • Data Source
      KAKENHI-PROJECT-19590112
  • [Presentation] プロリンミミックを含む[2', 6'-dimethyl-L-tyrosine1] endomorphin-2類似体のコンフォメーション解析2008

    • Author(s)
      津田裕子, 宮崎杏奈, 山田隆巳, 磯崎要, 下東康幸, 安保明博, 佐々木有亮, 箕浦克彦, 尹康子, 石田寿昌、岡田芳男
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19590112
  • [Presentation] 芳男:ピペリジンカルボン酸またはアゼチジンカルボン酸を含むエンドモルフィンー2類似体の合成2007

    • Author(s)
      津田裕子, 宮崎杏奈, 山田隆巳, 磯崎要, 下東康幸, 安保明博, 佐々木有亮, 岡田芳男
    • Organizer
      第44回ペプチド討論会
    • Place of Presentation
      富山
    • Data Source
      KAKENHI-PROJECT-19590112
  • 1.  TSUDA Yuko (10098478)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 13 results
  • 2.  YUKOI Toshio (50122255)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 3.  YAMAMOTO Junichiro (60068252)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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