• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

UCHIDA Yoko  内田 洋子

ORCIDConnect your ORCID iD *help
Researcher Number 60133633
External Links
Affiliation (based on the past Project Information) *help 2012: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員
2010 – 2011: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 主任研究員
2009: 東京都高齢者研究所, 主任研究員
2008 – 2009: Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 主任研究員
2008: Tokyo Metropolitan Institute of Gerontology, 主任研究員 … More
2007: (財)東京都高齢者研究福祉振興財団, 東京都老人総合研究所, 主任研究員
2007: Tokyo Metropolitan Institute of Gerontology, 東京都老人総合研究所, 主任研究員
2006: Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Institute of Gerontology, Senior Research Scientist
2005 – 2006: (財)東京都高齢者研究・福祉振興財団, 東京都老人総合研究所, 主任研究員
2004: 財団法人東京都高齢者研究, 福祉振興財団・東京都老人総合研究所, 主任研究員
2000: (財)東京都老人総合研究所, 神経病理部門, 研究員
1998 – 2000: 財団法人 東京都老人総合研究所, 神経病理部門, 研究員
1996 – 1997: 東京都老人総合研究所, 神経病理部門, 研究員
1994 – 1995: (財)東京都老人総合研究所, 神経病理部門, 研究員
1992 – 1993: 東京都老人総合研究所, 神経病理, 研究員
1991: 東京都老人総合研, 研究員
1991: 東京都老人総合研究所, 神経化学, 研究員
1990: 東京都老人総合研究所, 臨床病理, 研究員 Less
Review Section/Research Field
Principal Investigator
老化(加齢) / Nerve anatomy/Neuropathology / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Neuroscience in general
Except Principal Investigator
Neurology / Applied pharmacology
Keywords
Principal Investigator
MAP1B / βアミロイド / AICD / microarray / β-amyloid / 神経細胞死 / β-アミロイド / 胎児性抗原 / 神経毒性 / アルツハイマー病 … More / 成長抑制因子 / neuronal death / intracellular Aβ / 細胞死関連遺伝子 / 細胞内Ass / 細胞内Aβ / fetal antigens / neurotoxicity / 胎児性遺伝子 / 神経新生 / B-アミロイド / トランスジェニック マウス / 転写因子 / ss-アミロイド / 神経再生 / 神経幹細胞 / 遺伝子発現 / アストロサイト / 神経栄養因子 / ニューロン死 / 変性疾患 / 成長抑制因子(GIF) … More
Except Principal Investigator
神経成長因子 / アルツハイマー病 / 神経成長抑制因子 / メタロチオネイン / 海馬 / 神経栄養因子 / 神経細胞死 / cDNA / Metal responsive-element / Gene targeting / Metallothionein / Growth inhibitory factor (GIF) / Alzheimer's diseaase / gene targetting / ゲノム / cDNAクロ-ニング / 遺伝学 / 老年痴呆 / ジーン・ターゲティング / 金属反応部位 / 神経成長抑制因子(GIF) / 糖尿病 / メタボリック症候群 / 味蕾 / 老化 / 抗酸化作用 / 精神疾患 / 運動 / 低分子化合物 / 脳虚血 / 筋萎縮性側索硬化症 / 虚血脳 / ニュ-ロン / アルツハイマ-病 / 虚血性神経細胞死 / 神経突起伸展 / 成長阻害因子 Less
  • Research Projects

    (12 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (19 People)
  •  Mechanism of accelerating death of newborn neurons by ss-amyloidPrincipal Investigator

    • Principal Investigator
      UCHIDA Yoko
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
  •  Research on the roles of metallothioneins in aging, brain ischemia and metabolic syndrome and drug discover

    • Principal Investigator
      HOZUMI Isao
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied pharmacology
    • Research Institution
      Gifu University
  •  Molecular mechanism of neurogenesis in Alzheimer's diseasePrincipal Investigator

    • Principal Investigator
      UCHIDA Yoko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  Profiling of gene expression related neuronal death by intracellular Aβ1-42Principal Investigator

    • Principal Investigator
      UCHIDA Yoko
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  FETAL GENE EXPRESSION IN β-AMYLOID TREATED CORTICAL NEURONS AND ITS TOXIC OR PROTECTIVE EFFECTS ON NEURONSPrincipal Investigator

    • Principal Investigator
      UCHIDA Yoko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY
  •  βアミロイド神経毒性の分子機構Principal Investigator

    • Principal Investigator
      内田 洋子
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  成長抑制因子の発現調節機構Principal Investigator

    • Principal Investigator
      内田 洋子
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  成長抑制因子の標的となる神経栄養因子の同定Principal Investigator

    • Principal Investigator
      内田 洋子
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Neuroscience in general
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  ニューロン死における成長抑制因子の役割Principal Investigator

    • Principal Investigator
      内田 洋子
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Tokyo Metropolitan Institute of Gerontology
  •  アルツハイマ-病の脳における神経細胞死

    • Principal Investigator
      三木 直正
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  Molecular biology for Alzheimer's disease

    • Principal Investigator
      YUASA Tatsuhiko, 宮武 正
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University
  •  アルツハイマ-病の脳における神経細胞死

    • Principal Investigator
      三木 直正
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University

All 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

  • [Journal Article] Calsyntenin-3 C-terminal fragment accumulates in dystrophic neurites surrounding abeta plaques in tg2576 mouse and Alzheimer disease brains: its neurotoxic role in mediating dystrophic neurite formation.2013

    • Author(s)
      Uchida Y
    • Journal Title

      Am J Pathol.

      Volume: 182 Issue: 5 Pages: 1718-1726

    • DOI

      10.1016/j.ajpath.2013.01.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500347
  • [Journal Article] Calsyntenin-3 C-terminal fragment Accumulates in dystrophic neuritis surrounding abeta plaques in Tg2576 mouse and Alzheimer disease brains : its neurotoxic role in mediating dystrophic neurite formation.2013

    • Author(s)
      Uchida Y, Gomi F, Murayama S, Takahashi H.
    • Journal Title

      Am J Pathol

      Volume: 182 Pages: 1718-1726

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500347
  • [Journal Article] MAP1B 1-126 interacts with tubulin isoforms and induces neurite outgrowth and neuronal death of cultured cortical neurons.2012

    • Author(s)
      Gomi F, Uchida Y.
    • Journal Title

      Brain Res

      Volume: 1433 Pages: 1-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500347
  • [Journal Article] MAP1B 1-126 interacts with tubulin isoforms and induces neurite outgrowth and neuronal death of cultured cortical neurons2012

    • Author(s)
      Gomi F, Uchida Y
    • Journal Title

      Brain Res

      Volume: 1,433 Pages: 1-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500347
  • [Journal Article] Up-regulation of calsyntenin-3 by β-amyloid increases vulnerability of cortical neurons.2011

    • Author(s)
      Uchida Y, Nakano S, Gomi F, Takahashi H.
    • Journal Title

      FEBS Lett

      Volume: 585 Pages: 651-656

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500347
  • [Journal Article] Up-regulatioll of calsyntenin-3 by β-amyloid increases vulnerability of cortical neurons.2011

    • Author(s)
      Uchida Y, Nakano S, Gomi F, Takahashi H.
    • Journal Title

      FEBS Lett.

      Volume: 585 Pages: 651-656

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500347
  • [Journal Article] Molecular mechanisms of regeneration in Alzheimer's disease brain.2010

    • Author(s)
      Uchida Y
    • Journal Title

      Geriatr Gerontol Int

      Volume: 10 Suppl 1

    • NAID

      10027273631

    • Data Source
      KAKENHI-PROJECT-22500347
  • [Journal Article] Molecular mechanisms of regeneration in Alzheimer's disease brain2009

    • Author(s)
      Uchida Yoko
    • Journal Title

      Geriatrics and Gerontology International (In Press)

    • NAID

      10027273631

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500316
  • [Journal Article] Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors.2009

    • Author(s)
      Koumura A, Kakefuda K, Honda A, Ito Y, Tsuruma K, Shimazawa M, Uchida Y, Hozumi I, Satoh M, Inuzuka T, Hara H
    • Journal Title

      Neuroscience Letter 467

      Pages: 11-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390151
  • [Journal Article] Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia.2009

    • Author(s)
      Koumura A, Hamanaka J, Shimazawa M, Honda A, Tsuruma K, Uchida Y, Hozumi I, Satoh M, Inuzuka T, Hara H
    • Journal Title

      Brain Research 1292

      Pages: 148-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390151
  • [Journal Article] Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors2009

    • Author(s)
      Koumura A, Kakefuda K, Honda A, Ito Y, Tsuruma K, Shimazawa M, Uchida Y, Hozumi I, Satoh M, Inuzuka T, Hara H
    • Journal Title

      Neuroscience Letter 467

      Pages: 11-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390151
  • [Journal Article] Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia2009

    • Author(s)
      Koumura A, Hamanaka J, Shimazawa M, Honda A, Tsuruma K, Uchida Y, Hozumi I, Satoh M, Inuzuka T, Hara H.
    • Journal Title

      Brain Research 1292

      Pages: 148-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390151
  • [Journal Article] The expression of metallothionein is diminished in the spinal cords of patients with sporadic ALS.2008

    • Author(s)
      Hozumi I, Yamada M, Uchida Y, Ozawa K, Takahashi H, Inuzuka T.
    • Journal Title

      Amotrophic Lateral Sclerosis 9

      Pages: 294-298

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390151
  • [Journal Article] The expression of metallothionein is diminished in the spinal cords of patients with sporadic ALS.2008

    • Author(s)
      Hozumi I, Yamada M, Uchida Y, Ozawa K, Takahashi H, Inuzuka T.
    • Journal Title

      Amotrophic Lateral Sclerosis (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390151
  • [Journal Article] Rapid detection of Ass deposits in APP transgenic mice by Hoechst 333422008

    • Author(s)
      Uchida Y, Takahashi H
    • Journal Title

      Neurosci Lett 448

      Pages: 279-281

    • Data Source
      KAKENHI-PROJECT-19500316
  • [Journal Article] The expression of metallothionein is diminished in the spinal cords of patients with sporadic ALS.2008

    • Author(s)
      Hozumi I, Yamada M, Uchida Y, Ozawa K, Takahashi H, Inuzuka T
    • Journal Title

      Amotrophic Lateral Sclerosis 9

      Pages: 294-298

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390151
  • [Journal Article] Differential regulation of bHLH factors, Mash1 and Olig2, by ss-amyloid accelerates both differentiation and the death of cultured neural stem cells2007

    • Author(s)
      Uchida Y, Nakano S, Gomi F, Hakahashi H
    • Journal Title

      J Biol Chem 282

      Pages: 19700-19709

    • Data Source
      KAKENHI-PROJECT-19500316
  • [Journal Article] Differential regulation of bHLH factors,Mash1 and Olig2,by β-amyloid accelerates both differentiation and the death of cultured neural stem cells.2007

    • Author(s)
      Uchida Y, Nakano S, Gomi F, Takahashi H
    • Journal Title

      J Biol Chem 282

      Pages: 19700-19709

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19500316
  • [Journal Article] Molecular mechanisms of regeneration in Alzheimer's disease brain

    • Author(s)
      Uchida Y
    • Journal Title

      Geriatrics Gerontology International (in press)

    • NAID

      10027273631

    • Data Source
      KAKENHI-PROJECT-19500316
  • [Presentation] Chat過剰発現による神経細胞死に関与する分子の検討2012

    • Author(s)
      五味不二也、内田洋子
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22500347
  • [Presentation] Chatによる神経細胞死におけるNEDD9とp130Casの効果2011

    • Author(s)
      五味不二也、内田洋子
    • Organizer
      第34回に本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-17
    • Data Source
      KAKENHI-PROJECT-22500347
  • [Presentation] Assにより誘導されるCas/HEF1 associated signal transducer の細胞死への効果2010

    • Author(s)
      五味不二也、内田洋子
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22500347
  • [Presentation] ABにより誘導されるCas/HEFI associated signal transducerの細胞死への効果2010

    • Author(s)
      五味不二也、内田洋子
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22500347
  • [Presentation] Cas/HEF1 associated signal transducerによる神経細胞死2010

    • Author(s)
      五味不二也、内田洋子
    • Organizer
      第33回日本基礎老化学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22500347
  • [Presentation] Cas/HEFI associated signal transducerによる神経細胞死2010

    • Author(s)
      五味不二也、内田洋子
    • Organizer
      第33回日本基礎老化学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-22500347
  • [Presentation] アルツハイマー病モデルマウスにおけるbHLH因子の発現変化とその意味2007

    • Author(s)
      内田 洋子, 中野 俊一郎, 五味 不二也
    • Organizer
      日本基礎老化学会
    • Place of Presentation
      札幌市
    • Year and Date
      2007-06-21
    • Data Source
      KAKENHI-PROJECT-19500316
  • [Presentation] アルツハイマー病モデルマウスにおけるBhlh因子の発現変化とその意味2007

    • Author(s)
      内田洋子, 中野俊一郎, 五味不二也
    • Organizer
      日本基礎老化学会
    • Place of Presentation
      札幌市
    • Year and Date
      2007-06-21
    • Data Source
      KAKENHI-PROJECT-19500316
  • [Presentation] ADモデルマウス脳におけるOlig2遺伝子の発現変化とその意味2007

    • Author(s)
      内田 洋子, 五味 不二也
    • Organizer
      Neuro2007
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-10
    • Data Source
      KAKENHI-PROJECT-19500316
  • [Presentation] ADマウスモデル脳における Olig2 遺伝子の発現変化とその意味2007

    • Author(s)
      内田洋子, 五味不二也
    • Organizer
      Neuro 2007
    • Place of Presentation
      横浜市
    • Year and Date
      2007-09-10
    • Data Source
      KAKENHI-PROJECT-19500316
  • 1.  GOMI Fujiya (40205620)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 17 results
  • 2.  三木 直正 (40094445)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  山本 長三郎 (50008231)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  HOZUMI Isao (20242430)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 5.  INUZUKA Takashi (50184734)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 6.  HAYASHI Yuichi (00392366)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  HARA Hideaki (20381717)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 8.  SATOH Masahiko (20256390)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 9.  YUASA Tatsuhiko (10115090)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KATSUKI Motoya (20051732)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  IHARA Yasuo (60114386)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TSUJI Shoji (70150612)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  高橋 國太郎 (10010034)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  祖父江 憲治 (20112047)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  小暮 久也 (20133936)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  小宮 義璋 (50010046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  桐野 高明 (10161605)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  古川 昭栄 (90159129)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  宮武 正 (50048998)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi