ONISHI Saburou 大西三朗

… Alternative Names

大西三郎オオニシサブロウ

ONISHI Saburo 大西三朗

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Researcher Number	60136380
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2008: Kochi University, 教育研究部・医療学系, 教授 2008: Kochi University, 教育研究部医療学系, 教授 2003 – 2007: 高知大学, 医学部, 教授 1999 – 2002: 高知医科大学, 医学部, 教授 1995 – 1996: 高知医科大学, 医学部, 教授 … More 1993 – 1994: Kochi Medical School, Int Med, Associate Pr, 医学部, 助教授 1992: 高知医科大学, 医学部, 講師 1987 – 1990: 高知医科大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology
Keywords	Principal Investigator 原発性胆汁性肝硬変 / 胆管上皮抗原 / thymocyte / estrogen / エストロゲン / CTL / 自己免疫 / PBC / differentiation / 胸腺細胞 … More / CD25 / ArKO / 分化 / human biliary epithelial antigen / primary biliary cirrhosis / T cell proliferation / ヒト胆管上皮抗原 / 胆管炎 / Biliary duct epithelial antigen / Cytotoxic T lymphocyte / Primary biliary cirrhosis / インターロイキン1 / 胆管上皮抗原特異的免疫複合物 / リンパ球芽球化反応 / 細胞傷害性Tリンパ球 / B1抗原 / epithelial cell / autoimmunity / cholasngitis / 肥満 / インスリン抵抗性 / 肝線維化 / NASH動物モデル / 非アルコール性脂肪肝炎(NASH) / 胸腺上皮細胞 / gender / GVH / 分化異常 / 性差 / CD44 / aromatase / flowcytometry / auto immunity / 自己免疫性肝炎 / T細胞 / 胸腺 / CARCINOGENESIS / TRANSACTIVATION / HEPATOCELLULAR CARCINOMA / HEPATITIS B VIRUS / transgenic mouse / TGF-α / preS1 / tronsactivation / carcinogenesis / tronsactiration / 肝細胞癌 / B型肝炎ウィルス / biliary antigen / alpha-enolase antibody / Tap-genes / immunogenetics / 抗α-エノラーゼ抗体 / HLA遺伝子 / major histocompatibility antigen complex / T cell immunity / primry biliary cirrhosis / HLA‐DNA‐typing / 原発性胆汁性肝硬度 / 免疫遺伝学 / 主要組織適合抗原 / T細胞免疫 / Tリンパ球芽球化反応 / Tcell proliferation / mouse / autoimmune / apoptosis / death receptor / bile duct / 遺伝子多型 / death domain / TRAILレセプター / 胆管障害 / 胆汁性肝硬変 / TRAIL / 免疫遺伝 Less

Development of an animal model of the vanishing bile duct syndromePrincipal Investigator
- Principal Investigator
  
  ONISHI Saburou
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi University
Role of thymocyte differentiation in the progression of primary biliary cirrhosisPrincipal Investigator
- Principal Investigator
  
  ONICHI Saburo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi University
Primary biliary cirrhosis and estrogen-mediated regulation of CD4+CD25+ thymocyte differentiation.Principal Investigator
- Principal Investigator
  
  ONISHI Saburo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi Medical School
  高知大学(医学部)
Modulation of thymocyte development by estrogen and autoimmune hepatitisPrincipal Investigator
- Principal Investigator
  
  ONISHI Saburo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi medical School
PRES1 CONTRIBUTES IN HEPATOCARCINOGENESIS IN PATIENTS WITH HBV INFECTIONPrincipal Investigator
- Principal Investigator
  
  ONISHI Saburo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  KOCHI MEDICAL SCHOOL
Autoimmune-mediated mechanism of biliary injury in primary biliary cirrhosisPrincipal Investigator
- Principal Investigator
  
  ONISHI Saburo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi Medical School
原発性胆汁性肝硬変におけるHLA DR8を介した胆管抗原p28の抗原呈示Principal Investigator
- Principal Investigator
  
  大西三朗
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  高知医科大学
T cell immunity to biliary epithelial antigen in primary biliary cirrhosis.Principal Investigator
- Principal Investigator
  
  ONISHI Saburo
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi Medical School
Purification of Human Biliary Epithelial Antigen and T Cell Autoimmunity in Patients with Primary biliary CirrchosisPrincipal Investigator
- Principal Investigator
  
  ONISHI Saburo
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi Medical School
Autoimmunity to Bile Duct Epithelial Cells in Patients with Primary Billary CirrhosisPrincipal Investigator
- Principal Investigator
  
  ONISHI Saburo
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kochi Medical School

All 2008 2007 2006 2005

All Journal Article Presentation Book

[Book] 酸化ストレスと肝疾患2008
- Author(s)
  杜井峰、小笠原光成、植瑞希、廣瀬享、野崎靖子、小野正文、岩崎信二、西原利治、大西三朗
- Publisher
  メディカルジャーナル社
- Data Source
  KAKENHI-PROJECT-19590773
[Book] アルコールと医学生物学2007
- Author(s)
  李春媚、小笠原光成、植瑞希、廣瀬享、野崎靖子、高橋昌也、小野正文、岩崎信二、西原利治、大西三朗
- Publisher
  東洋書店
- Data Source
  KAKENHI-PROJECT-19590773
[Book] わかりやすい内科学2007
- Author(s)
  西原利治、大西三朗
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-19590773
[Book] 肝臓病の最新治療2007
- Author(s)
  西原利治、小野正文、大西三朗
- Publisher
  先端医療技術研究所
- Data Source
  KAKENHI-PROJECT-19590773
[Book] 肝硬変のマネジメント2007
- Author(s)
  西原利治、小野正文、大西三朗
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-19590773
[Book] 「消化器疾患」II肝胆膵2006
- Author(s)
  西原利治, 大西三朗
- Total Pages
  726
- Publisher
  医歯薬出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590655
[Book] 「消化器疾患ガイドライン」非アルコール性脂肪性肝疾患2006
- Author(s)
  西原利治, 大西三朗
- Total Pages
  247
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-17590655
[Book] 消化器疾患の診断基準、病型分類、重症度の用い方(非アルコール性脂肪肝炎の診断基準)2006
- Author(s)
  西原利治, 大西三朗
- Total Pages
  369
- Publisher
  日本メディカルセンター
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590655
[Book] 「図解消化器内科学テキスト」脂肪肝、非アルコール性脂肪肝炎2006
- Author(s)
  西原利治, 小野正文, 大西三朗
- Total Pages
  445
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-17590655
[Book] 「消化器疾患の診断基準、病型分類、重症度の用い方」非アルコール性脂肪肝炎の診断基準2006
- Author(s)
  西原利治, 大西三朗
- Total Pages
  369
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-17590655
[Book] 消化器疾患ガイドライン(非知レコール性脂肪性肝疾患)2006
- Author(s)
  西原利治, 大西三朗
- Total Pages
  247
- Publisher
  総合医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590655
[Book] NAFLDのすべて2006
- Author(s)
  西原利治, 大西三朗
- Publisher
  医歯薬出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590655
[Book] 図解消化器内科学テキスト(脂肪肝、非アルコール性脂肪肝炎)2006
- Author(s)
  西原利治, 小野正文, 大西三朗
- Total Pages
  445
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590655
[Journal Article] Fibrate for treatment of primary biliary cirrhosis2007
- Author(s)
  Iwasaki S, Akisawa N, Saibara T, Onishi S.
- Journal Title
  
  Hepatol Res 37 (Suppl 3)
- NAID
  10019797596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590773
[Journal Article] Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis2007
- Author(s)
  Hirose A, Ono M, Saibara T, Nozaki Y, Masuda K, Yoshioka A, Takahashi M, Akisawa N, Iwasaki S, Oben JA, Onishi S.
- Journal Title
  
  Hepatology 45
  
  Pages: 1375-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590773
[Journal Article] The phosphatidyl ethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population2007
- Author(s)
  Dong H, Wang J, Li C, Hirose A, Nozaki Y, Takahashi M, Ono M, Akisawa N, Iwasaki S, Saibara T, Onishi S.
- Journal Title
  
  J Hepatol 46
  
  Pages: 915-920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590773
[Journal Article] In vivo imaging of hepatic fatty acid metabolism in patients with non-alcoholic steatohepatitis using semiquantitative I-labeled branched-chain fatty acid analog.2006
- Author(s)
  Onishi S, et al.
- Journal Title
  
  J Gastroenterol Hepatol. 21 Suppl 3
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590655
[Journal Article] In vivo imaging of hepatic fatty acid metabolism in patients with non-alcoholic steatohepatitis using semiquantitative I-labeled branched-chain fatty acid analog.2006
- Author(s)
  Onishi S, et al.
- Journal Title
  
  J Gastroenterol Hepatol. 21(Suppl 3)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590655
[Journal Article] CYP17 polymorphism as a risk factor of tamoxifen-induced hepatic steatosis in breast cancer patients.2005
- Author(s)
  Onishi T
- Journal Title
  
  Oncol Rep 13
  
  Pages: 465-489
- Data Source
  KAKENHI-PROJECT-17590655
[Presentation] Methionine-choline metabolism is involved in the pathogenesis of nonalcoholic steatohepatitis2008
- Author(s)
  Tokumitsu K, Ogasawara K, Maki M, Hirose A, Nozaki Y, Takahashi M, Ono M, Iwasaki S, Saibara T, Onishi S.
- Organizer
  European Association for the Study of Liver Disease
- Place of Presentation
  Milan, Italy
- Year and Date
  2008-04-24
- Data Source
  KAKENHI-PROJECT-19590773
[Presentation] Angiotensin II type 1 receptor blocker attenuates the progression of nonalcoholic steatohepatitis (NASH)2008
- Author(s)
  Hirose A, Ono M, Saibara T, Nozaki Y, Takahashi M, Iwasaki S, Oben JA, Onishi S.
- Organizer
  European Association for the Study of Liver Disease
- Place of Presentation
  Milan, Italy
- Year and Date
  2008-04-24
- Data Source
  KAKENHI-PROJECT-19590773
[Presentation] Super-paramagnetic iron oxide-MRI : A novel technique in experimental liver studies shows defective Kupffer cell phagocytic function in human non alcoholic fatty liver disease2008
- Author(s)
  Ono M, Kubota K, Hirose A, Nozaki Y, Takahashi M, Iwasaki S, Saibara T, Ogawa Y, Onishi S, Oben JA
- Organizer
  European Association for the Study of Liver Disease
- Place of Presentation
  Milan, Italy
- Year and Date
  2008-04-24
- Data Source
  KAKENHI-PROJECT-19590773
[Presentation] Secondary extrahepatic portal obstruction resulted from thrombus in splenic vein aneurysma2008
- Author(s)
  Kuratani Y, Ichikawa H, Hirose A, Nozaki Y, Takahashi M, Iwasaki S, Saibara T, Onishi S.
- Organizer
  7^<th> Japan Society of Hepatology Single Topic Conference
- Place of Presentation
  Fukuoka
- Year and Date
  2008-09-29
- Data Source
  KAKENHI-PROJECT-19590773
[Presentation] Angiotensin II type 1 receptor blocker inhibits fibrosis in rats steatohepatitis2007
- Author(s)
  Ono M, Hirose A, Saibara T, Nozaki Y, Masuda K, Yoshioka A, Takahashi M, Akisawa N, Iwasaki S, Onishi S
- Organizer
  17^<th> Asia-Pacific Association for the Study of Liver Disease
- Place of Presentation
  Kyoto
- Year and Date
  2007-03-30
- Data Source
  KAKENHI-PROJECT-19590773
[Presentation] Possibie involvement of impaired choline-methionine metabolism in the pathogenesis of nonalcoholic fatty liver disease2007
- Author(s)
  T.Saibara, M.Ono, S.Onishi
- Organizer
  Asia Pasific digestive week 2007
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-19590773
[Presentation] The Cog2 gene A2217G single nucleotide polymorphism confers susceptibility to hepatocyte ballooning in NASH patients2007
- Author(s)
  Saibara T, Yoshioka A, Hirose A, Nozaki Y, Takahashi M, Ono M, Iwasaki S, Onishi S
- Organizer
  Asia Pacific digestive week 2007
- Place of Presentation
  Kobe
- Year and Date
  2007-10-16
- Data Source
  KAKENHI-PROJECT-19590773
[Presentation] The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population2007
- Author(s)
  Saibara T, Yoshioka A, Hirose A, Nozaki Y, Takahashi M, Ono M, Iwasaki S, Onishi S
- Organizer
  Asia Pacific digestive week 2007
- Place of Presentation
  Kobe
- Year and Date
  2007-10-16
- Data Source
  KAKENHI-PROJECT-19590773
[Presentation] Metabolic syndrome as the pathogenic background for the development of NASH2007
- Author(s)
  Saibara T, Ono M, Hirose A, Onishi S
- Organizer
  17^<th> Asia-Pacific Association for the Study of Liver Disease
- Place of Presentation
  Kyoto
- Year and Date
  2007-03-30
- Data Source
  KAKENHI-PROJECT-19590773

1. SAIBARA Toshiji (60145125)

# of Collaborated Projects: 8 results

# of Collaborated Products: 25 results
2. MAEDA Takashi (80183606)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. AKISAWA Naoaki (00322280)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAKAHASHI Masaya (80380335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. MIYAZAKI Masako (60166155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. IWASAKI Shinji (10232654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TANIGUCHI Taketoshi (90127944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小野正文 (70304681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ONISHI Saburou 大西 三朗

大西 三郎 オオニシ サブロウ

ONISHI Saburo 大西 三朗

Research Projects

Research Products

Co-Researchers

Development of an animal model of the vanishing bile duct syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of thymocyte differentiation in the progression of primary biliary cirrhosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Primary biliary cirrhosis and estrogen-mediated regulation of CD4+CD25+ thymocyte differentiation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modulation of thymocyte development by estrogen and autoimmune hepatitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PRES1 CONTRIBUTES IN HEPATOCARCINOGENESIS IN PATIENTS WITH HBV INFECTIONPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Autoimmune-mediated mechanism of biliary injury in primary biliary cirrhosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

原発性胆汁性肝硬変におけるHLA DR8を介した胆管抗原p28の抗原呈示Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

T cell immunity to biliary epithelial antigen in primary biliary cirrhosis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Purification of Human Biliary Epithelial Antigen and T Cell Autoimmunity in Patients with Primary biliary CirrchosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Autoimmunity to Bile Duct Epithelial Cells in Patients with Primary Billary CirrhosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 酸化ストレスと肝疾患2008

Author(s)

Publisher

Data Source

[Book] アルコールと医学生物学2007

Author(s)

Publisher

Data Source

[Book] わかりやすい内科学2007

Author(s)

Publisher

Data Source

[Book] 肝臓病の最新治療2007

Author(s)

ONISHI Saburou 大西三朗

大西三郎オオニシサブロウ

ONISHI Saburo 大西三朗