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ONISHI Saburou  大西 三朗

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… Alternative Names

大西 三郎  オオニシ サブロウ

ONISHI Saburo  大西 三朗

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Researcher Number 60136380
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2008: Kochi University, 教育研究部・医療学系, 教授
2008: Kochi University, 教育研究部医療学系, 教授
2003 – 2007: 高知大学, 医学部, 教授
1999 – 2002: 高知医科大学, 医学部, 教授
1995 – 1996: 高知医科大学, 医学部, 教授 … More
1993 – 1994: Kochi Medical School, Int Med, Associate Pr, 医学部, 助教授
1992: 高知医科大学, 医学部, 講師
1987 – 1990: 高知医科大学, 医学部, 講師 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology
Keywords
Principal Investigator
原発性胆汁性肝硬変 / 胆管上皮抗原 / thymocyte / estrogen / エストロゲン / CTL / 自己免疫 / PBC / differentiation / 胸腺細胞 … More / CD25 / ArKO / 分化 / human biliary epithelial antigen / primary biliary cirrhosis / T cell proliferation / ヒト胆管上皮抗原 / 胆管炎 / Biliary duct epithelial antigen / Cytotoxic T lymphocyte / Primary biliary cirrhosis / インターロイキン1 / 胆管上皮抗原特異的免疫複合物 / リンパ球芽球化反応 / 細胞傷害性Tリンパ球 / B1抗原 / epithelial cell / autoimmunity / cholasngitis / 肥満 / インスリン抵抗性 / 肝線維化 / NASH動物モデル / 非アルコール性脂肪肝炎(NASH) / 胸腺上皮細胞 / gender / GVH / 分化異常 / 性差 / CD44 / aromatase / flowcytometry / auto immunity / 自己免疫性肝炎 / T細胞 / 胸腺 / CARCINOGENESIS / TRANSACTIVATION / HEPATOCELLULAR CARCINOMA / HEPATITIS B VIRUS / transgenic mouse / TGF-α / preS1 / tronsactivation / carcinogenesis / tronsactiration / 肝細胞癌 / B型肝炎ウィルス / biliary antigen / alpha-enolase antibody / Tap-genes / immunogenetics / 抗α-エノラーゼ抗体 / HLA遺伝子 / major histocompatibility antigen complex / T cell immunity / primry biliary cirrhosis / HLA‐DNA‐typing / 原発性胆汁性肝硬度 / 免疫遺伝学 / 主要組織適合抗原 / T細胞免疫 / Tリンパ球芽球化反応 / Tcell proliferation / mouse / autoimmune / apoptosis / death receptor / bile duct / 遺伝子多型 / death domain / TRAILレセプター / 胆管障害 / 胆汁性肝硬変 / TRAIL / 免疫遺伝 Less
  • Research Projects

    (10 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (8 People)
  •  Development of an animal model of the vanishing bile duct syndromePrincipal Investigator

    • Principal Investigator
      ONISHI Saburou
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kochi University
  •  Role of thymocyte differentiation in the progression of primary biliary cirrhosisPrincipal Investigator

    • Principal Investigator
      ONICHI Saburo
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kochi University
  •  Primary biliary cirrhosis and estrogen-mediated regulation of CD4+CD25+ thymocyte differentiation.Principal Investigator

    • Principal Investigator
      ONISHI Saburo
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kochi Medical School
      高知大学(医学部)
  •  Modulation of thymocyte development by estrogen and autoimmune hepatitisPrincipal Investigator

    • Principal Investigator
      ONISHI Saburo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kochi medical School
  •  PRES1 CONTRIBUTES IN HEPATOCARCINOGENESIS IN PATIENTS WITH HBV INFECTIONPrincipal Investigator

    • Principal Investigator
      ONISHI Saburo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      KOCHI MEDICAL SCHOOL
  •  Autoimmune-mediated mechanism of biliary injury in primary biliary cirrhosisPrincipal Investigator

    • Principal Investigator
      ONISHI Saburo
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kochi Medical School
  •  原発性胆汁性肝硬変におけるHLA DR8を介した胆管抗原p28の抗原呈示Principal Investigator

    • Principal Investigator
      大西 三朗
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      高知医科大学
  •  T cell immunity to biliary epithelial antigen in primary biliary cirrhosis.Principal Investigator

    • Principal Investigator
      ONISHI Saburo
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kochi Medical School
  •  Purification of Human Biliary Epithelial Antigen and T Cell Autoimmunity in Patients with Primary biliary CirrchosisPrincipal Investigator

    • Principal Investigator
      ONISHI Saburo
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kochi Medical School
  •  Autoimmunity to Bile Duct Epithelial Cells in Patients with Primary Billary CirrhosisPrincipal Investigator

    • Principal Investigator
      ONISHI Saburo
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kochi Medical School

All 2008 2007 2006 2005

All Journal Article Presentation Book

  • [Book] 酸化ストレスと肝疾患2008

    • Author(s)
      杜井峰、小笠原光成、植瑞希、廣瀬享、野崎靖子、小野正文、岩崎信二、西原利治、大西三朗
    • Publisher
      メディカルジャーナル社
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Book] アルコールと医学生物学2007

    • Author(s)
      李春媚、小笠原光成、植瑞希、廣瀬享、野崎靖子、高橋昌也、小野正文、岩崎信二、西原利治、大西三朗
    • Publisher
      東洋書店
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Book] わかりやすい内科学2007

    • Author(s)
      西原利治、大西三朗
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Book] 肝臓病の最新治療2007

    • Author(s)
      西原利治、小野正文、大西三朗
    • Publisher
      先端医療技術研究所
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Book] 肝硬変のマネジメント2007

    • Author(s)
      西原利治、小野正文、大西三朗
    • Publisher
      医薬ジャーナル社
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Book] 「消化器疾患」II肝胆膵2006

    • Author(s)
      西原利治, 大西三朗
    • Total Pages
      726
    • Publisher
      医歯薬出版
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590655
  • [Book] 「消化器疾患ガイドライン」非アルコール性脂肪性肝疾患2006

    • Author(s)
      西原利治, 大西三朗
    • Total Pages
      247
    • Publisher
      総合医学社
    • Data Source
      KAKENHI-PROJECT-17590655
  • [Book] 消化器疾患の診断基準、病型分類、重症度の用い方(非アルコール性脂肪肝炎の診断基準)2006

    • Author(s)
      西原利治, 大西三朗
    • Total Pages
      369
    • Publisher
      日本メディカルセンター
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590655
  • [Book] 「図解消化器内科学テキスト」脂肪肝、非アルコール性脂肪肝炎2006

    • Author(s)
      西原利治, 小野正文, 大西三朗
    • Total Pages
      445
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-17590655
  • [Book] 「消化器疾患の診断基準、病型分類、重症度の用い方」非アルコール性脂肪肝炎の診断基準2006

    • Author(s)
      西原利治, 大西三朗
    • Total Pages
      369
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-17590655
  • [Book] 消化器疾患ガイドライン(非知レコール性脂肪性肝疾患)2006

    • Author(s)
      西原利治, 大西三朗
    • Total Pages
      247
    • Publisher
      総合医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590655
  • [Book] NAFLDのすべて2006

    • Author(s)
      西原利治, 大西三朗
    • Publisher
      医歯薬出版
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590655
  • [Book] 図解消化器内科学テキスト(脂肪肝、非アルコール性脂肪肝炎)2006

    • Author(s)
      西原利治, 小野正文, 大西三朗
    • Total Pages
      445
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590655
  • [Journal Article] Fibrate for treatment of primary biliary cirrhosis2007

    • Author(s)
      Iwasaki S, Akisawa N, Saibara T, Onishi S.
    • Journal Title

      Hepatol Res 37 (Suppl 3)

    • NAID

      10019797596

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Journal Article] Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis2007

    • Author(s)
      Hirose A, Ono M, Saibara T, Nozaki Y, Masuda K, Yoshioka A, Takahashi M, Akisawa N, Iwasaki S, Oben JA, Onishi S.
    • Journal Title

      Hepatology 45

      Pages: 1375-81

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Journal Article] The phosphatidyl ethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population2007

    • Author(s)
      Dong H, Wang J, Li C, Hirose A, Nozaki Y, Takahashi M, Ono M, Akisawa N, Iwasaki S, Saibara T, Onishi S.
    • Journal Title

      J Hepatol 46

      Pages: 915-920

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Journal Article] In vivo imaging of hepatic fatty acid metabolism in patients with non-alcoholic steatohepatitis using semiquantitative I-labeled branched-chain fatty acid analog.2006

    • Author(s)
      Onishi S, et al.
    • Journal Title

      J Gastroenterol Hepatol. 21 Suppl 3

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590655
  • [Journal Article] In vivo imaging of hepatic fatty acid metabolism in patients with non-alcoholic steatohepatitis using semiquantitative I-labeled branched-chain fatty acid analog.2006

    • Author(s)
      Onishi S, et al.
    • Journal Title

      J Gastroenterol Hepatol. 21(Suppl 3)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590655
  • [Journal Article] CYP17 polymorphism as a risk factor of tamoxifen-induced hepatic steatosis in breast cancer patients.2005

    • Author(s)
      Onishi T
    • Journal Title

      Oncol Rep 13

      Pages: 465-489

    • Data Source
      KAKENHI-PROJECT-17590655
  • [Presentation] Methionine-choline metabolism is involved in the pathogenesis of nonalcoholic steatohepatitis2008

    • Author(s)
      Tokumitsu K, Ogasawara K, Maki M, Hirose A, Nozaki Y, Takahashi M, Ono M, Iwasaki S, Saibara T, Onishi S.
    • Organizer
      European Association for the Study of Liver Disease
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2008-04-24
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Presentation] Angiotensin II type 1 receptor blocker attenuates the progression of nonalcoholic steatohepatitis (NASH)2008

    • Author(s)
      Hirose A, Ono M, Saibara T, Nozaki Y, Takahashi M, Iwasaki S, Oben JA, Onishi S.
    • Organizer
      European Association for the Study of Liver Disease
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2008-04-24
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Presentation] Super-paramagnetic iron oxide-MRI : A novel technique in experimental liver studies shows defective Kupffer cell phagocytic function in human non alcoholic fatty liver disease2008

    • Author(s)
      Ono M, Kubota K, Hirose A, Nozaki Y, Takahashi M, Iwasaki S, Saibara T, Ogawa Y, Onishi S, Oben JA
    • Organizer
      European Association for the Study of Liver Disease
    • Place of Presentation
      Milan, Italy
    • Year and Date
      2008-04-24
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Presentation] Secondary extrahepatic portal obstruction resulted from thrombus in splenic vein aneurysma2008

    • Author(s)
      Kuratani Y, Ichikawa H, Hirose A, Nozaki Y, Takahashi M, Iwasaki S, Saibara T, Onishi S.
    • Organizer
      7^<th> Japan Society of Hepatology Single Topic Conference
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-09-29
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Presentation] Angiotensin II type 1 receptor blocker inhibits fibrosis in rats steatohepatitis2007

    • Author(s)
      Ono M, Hirose A, Saibara T, Nozaki Y, Masuda K, Yoshioka A, Takahashi M, Akisawa N, Iwasaki S, Onishi S
    • Organizer
      17^<th> Asia-Pacific Association for the Study of Liver Disease
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-03-30
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Presentation] Possibie involvement of impaired choline-methionine metabolism in the pathogenesis of nonalcoholic fatty liver disease2007

    • Author(s)
      T.Saibara, M.Ono, S.Onishi
    • Organizer
      Asia Pasific digestive week 2007
    • Place of Presentation
      Kobe
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Presentation] The Cog2 gene A2217G single nucleotide polymorphism confers susceptibility to hepatocyte ballooning in NASH patients2007

    • Author(s)
      Saibara T, Yoshioka A, Hirose A, Nozaki Y, Takahashi M, Ono M, Iwasaki S, Onishi S
    • Organizer
      Asia Pacific digestive week 2007
    • Place of Presentation
      Kobe
    • Year and Date
      2007-10-16
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Presentation] The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population2007

    • Author(s)
      Saibara T, Yoshioka A, Hirose A, Nozaki Y, Takahashi M, Ono M, Iwasaki S, Onishi S
    • Organizer
      Asia Pacific digestive week 2007
    • Place of Presentation
      Kobe
    • Year and Date
      2007-10-16
    • Data Source
      KAKENHI-PROJECT-19590773
  • [Presentation] Metabolic syndrome as the pathogenic background for the development of NASH2007

    • Author(s)
      Saibara T, Ono M, Hirose A, Onishi S
    • Organizer
      17^<th> Asia-Pacific Association for the Study of Liver Disease
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-03-30
    • Data Source
      KAKENHI-PROJECT-19590773
  • 1.  SAIBARA Toshiji (60145125)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 25 results
  • 2.  MAEDA Takashi (80183606)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  AKISAWA Naoaki (00322280)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  TAKAHASHI Masaya (80380335)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 5.  MIYAZAKI Masako (60166155)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  IWASAKI Shinji (10232654)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  TANIGUCHI Taketoshi (90127944)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  小野 正文 (70304681)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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