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SAIKAWA Tetsunori  犀川 哲典

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… Alternative Names

犀川 哲典  サイカワ テツノリ

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Researcher Number 60145365
Other IDs
Affiliation (based on the past Project Information) *help 2010 – 2013: 大分大学, 医学部, 教授
2005 – 2006: 大分大学, 医学部, 教授
1999: 大分医科大学, 医学部, 教授
1998: 大分医科大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine / Circulatory organs internal medicine
Except Principal Investigator
Emergency medicine / General physiology
Keywords
Principal Investigator
ischemic tolerance / Akt / P13 kinase / heat shock proteins / PI3k / HSP / PI3キナーゼ / 熱ショック蛋白質 / 虚血再灌流障害 / インスリン抵抗性 … More / 性ホルモン / 海馬 / 活動電位 / 自律神経 / 心臓メモリー / 不整脈 … More
Except Principal Investigator
虚血再灌流障害 / 酸化ストレス / メタボリック症候群 / 心房細動 / 心筋障害 / マイクロRNA / 活性酸素種 / 血糖変動 / 病態生理 Less
  • Research Projects

    (4 results)
  • Research Products

    (43 results)
  • Co-Researchers

    (4 People)
  •  Novel Strategy to prevent ischemia/reperfusion injury that overcomes disadvantages of antioxidant agents

    • Principal Investigator
      TAKAHASHI NAOHIKO
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Emergency medicine
    • Research Institution
      Oita University
  •  Elucidation of the effect and mechanism of repeated hypoglycemiaon cardiomyocytes in an animal model of diabetes mellitus

    • Principal Investigator
      TESHIMA Yasushi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Oita University
  •  The regulation of heat shock protein expression by sex hormone; the role of PI3kinase, Akt and GSK3betaPrincipal Investigator

    • Principal Investigator
      SAIKAWA Tetsunori
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Oita University
  •  中枢神経による心臓メモリーの修飾とそのメカニズムの解明Principal Investigator

    • Principal Investigator
      犀川 哲典
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      大分医科大学

All 2014 2013 2012 2011 2007 2006 2005 Other

All Journal Article Presentation

  • [Journal Article] Production of reactive oxygen species in the diabetic heart. Roles of mitochondria and NADPH oxidase2014

    • Author(s)
      Teshima Y, Takahashi N, Nishio S, Saito S, Kondo H, Fukui A, Aoki K, Yufu K, Nakagawa M, Saikawa T
    • Journal Title

      Circ J

      Volume: 78(2) Pages: 300-306

    • NAID

      130003382238

    • Data Source
      KAKENHI-PROJECT-23592672
  • [Journal Article] Role of leptin signaling in the pathogenesis of angiotensin II-mediated atrial fibrosisand fibrillation2013

    • Author(s)
      Fukui A, Takahashi N, Nakada C, Masaki T, Kume O, Shinohara T, Teshima Y, Hara M, Saikawa T
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 6(2) Pages: 402-409

    • Data Source
      KAKENHI-PROJECT-23592672
  • [Journal Article] Role of Leptin Signaling in the Pathogenesis of Angiotensin II-Mediated Atrial Fibrosis and Fibrillation.2013

    • Author(s)
      Fukui A, Takahashi N, Nakada C, Masaki T, Kume O, Shinohara T, Teshima Y, Hara M, Saikawa T.
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 2 Issue: 2 Pages: 402-9

    • DOI

      10.1161/circep.111.000104

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592672, KAKENHI-PROJECT-23790249
  • [Journal Article] Activation of CaMKII as a key regulator of reactive oxygen species production in diabetic rat heart2012

    • Author(s)
      Nishio S, Teshima Y, Takahashi N, Thuc LC, Saito S, Fukui A, Kume O, Fukunaga N, Hara M, Nakagawa M, Saikawa T
    • Journal Title

      J Mol Cell Cardiol

      Volume: 52 Pages: 1103-1111

    • Data Source
      KAKENHI-PROJECT-22590209
  • [Journal Article] Activation of CaMKII as a key regulator of reactive oxygen species production in diabetic rat heart.2012

    • Author(s)
      Nishio S, Teshima Y, Takahashi N, Thuc LC, Saito S, Fukui A, Kume O, Fukunaga N, Hara M, Nakagawa M, Saikawa T.
    • Journal Title

      J Mol Cell Cardiol

      Volume: 52 Pages: 1103-1111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592672
  • [Journal Article] Establishment of a model of atrial fibrillation associated with chronic kidney disease in rats and the role of oxidative stress.2012

    • Author(s)
      Fukunaga N, Takahashi N, Hagiwara S, Kume O, Fukui A, Teshima Y, Shinohara T, Nawata T, Hara M, Noguchi T, Saikawa T.
    • Journal Title

      Heart Rhythm

      Volume: 12 Issue: 12 Pages: 2023-31

    • DOI

      10.1016/j.hrthm.2012.08.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592672
  • [Journal Article] Inhibition of Na(+) -H(+) exchange as a mechanism of rapid cardioprotection by resveratrol.2012

    • Author(s)
      Thuc LC, Teshima Y, Takahashi N, Nishio S, Fukui A, Kume O, Saito S, Nakagawa M, Saikawa T
    • Journal Title

      Br J Pharmacol

      Volume: Epub ahead Issue: 6 Pages: 1745-1755

    • DOI

      10.1111/j.1476-5381.2012.01877.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592672
  • [Journal Article] Activation of CaMKII as a key regulator of reactive oxygen species production in diabetic rat heart2012

    • Author(s)
      Satoru Nishio, Yasushi Teshima, Tetsunori Saikawa
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: (In Press) Issue: 5 Pages: 1103-1111

    • DOI

      10.1016/j.yjmcc.2012.02.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Journal Article] Candesartan restored cardiac Hsp72 expression and tolerance against reperfusion injury in hereditary insulin-resistant rats.2011

    • Author(s)
      Taniguchi Y, Takahashi N, Fukui A, Nagano-Torigoe Y, Thuc LC, Teshima Y, Shinohara T, Wakisaka O, Ooie T, Murozono Y, Yufu K, Nakagawa M, Hara M, Yoshimatsu H, Saikawa T.
    • Journal Title

      Cardiovasc Res

      Volume: 23 Pages: 433-435

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592672
  • [Journal Article] Receptor-mediated suppression of cardiac HSP72 expression by testosterone in male rat heart.2007

    • Author(s)
      Kohno H, Takahashi N, Shinohara T, Ooie T, Yufu K, Nakagawa M, Yonemochi H, Hara M, Saikawa T, Yoshimatsu H.
    • Journal Title

      Endocrinology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590756
  • [Journal Article] Diazoxide-induced cardioprotection via DeltaPsim loss depending on timing of application.2006

    • Author(s)
      Yonemochi H, Ichinose M, Anan F, Taniguti Y, Shinohara T, Takahashi N, Nakagawa M, Saikawa T.
    • Journal Title

      Life Sci. 79

      Pages: 1906-1912

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590756
  • [Journal Article] Diazoxide-induced cardioprotection via DeltaPsim loss depending on timing of application.2006

    • Author(s)
      Yonemochi H, Ichinose M, Anan F, Taniguti Y, Shinohara T, Takahashi N, Nakagawa M, Saikawa T.
    • Journal Title

      Life Sci 79

      Pages: 1906-1912

    • Data Source
      KAKENHI-PROJECT-17590756
  • [Journal Article] Diazoxide-induced cardioprotection via DeltaPsim loss depending on timing of application.2006

    • Author(s)
      Yonemochi H, Ichinose M, Anan F, Taniguti Y, Shinohara T, Takahashi N, Nakagawa M, Saikawa T
    • Journal Title

      Life Sci 79

      Pages: 1906-1912

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590756
  • [Journal Article] Phosphatidylinositol 3 kinase-dependent activation of Akt, an essential signal for hyperthermia-induced heat shock protein 72, is attenuated in streptozotocin-induced diabetic heart.2006

    • Author(s)
      Shinohara T, Takahashi N, Ooie T, Hara M, Shigematsu S, Nakagawa M, Yonemochi H, Saikawa T, Yoshimatsu H.
    • Journal Title

      Diabetes 55

      Pages: 1307-1315

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590756
  • [Journal Article] Phosphatidylinositol 3 kinase-dependent activation of Akt, an essential signal for hyperthermia-induced heat shock protein 72, is attenuated in streptozotocin-induced diabetic heart.2006

    • Author(s)
      Shinohara T, Takahashi N, Ooie T, Hara M, Shigematsu S, Nakagawa M, Yonemochi H, Saikawa T, Yoshimatsu H
    • Journal Title

      Diabetes 55

      Pages: 1307-1315

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590756
  • [Journal Article] Pioglitazone but not glibenclamide improves cardiac expression of heat-shock protein 72 and tolerance against ischemia/reperfusion Injury in the heredity insulin-resistant rat.2006

    • Author(s)
      Taniguchi Y, Ooie T, Takahashi N, Shinohara T, Nakagawa M, Yonemochi Y, Hara M, Yoshimatsu H, Saikawa T
    • Journal Title

      Diabetes 55

      Pages: 2371-2378

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590756
  • [Journal Article] Pioglitazone but not glibenclamide improves cardiac expression of heat-shock protein 72 and tolerance against ischemia/reperfusion Injury in the heredity insulin-resistant rat.2006

    • Author(s)
      Taniguchi Y, Ooie T, Takahashi N, Shinohara T, Nakagawa M, Yonemochi Y, Hara M, Yoshimatsu H, Saikawa T.
    • Journal Title

      Diabetes 55

      Pages: 2371-2378

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590756
  • [Journal Article] Effects of insulin resistance on geranylgeranylacetone-induced expression of heat shock protein 72 and cardioprotection in high-fat diet rats.2005

    • Author(s)
      Ooie T, Kajimito M, Takahashi N, Shinohara T, Taniguchi Y, Kouno H, Wakisaka M, Yoshimatsu H, Saikawa T
    • Journal Title

      Life Sci. 77

      Pages: 869-881

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590756
  • [Journal Article] Oral administration of geranylgeranylacetone blunts the endothelial dysfunction induced by ischemia and reperfusion in the rat heart.2005

    • Author(s)
      Zhu Z, Takahashi N, Ooie T, Shinohara T, Yamanaka K, Saikawa T
    • Journal Title

      J. Cardiovasc. Pharmacol. 45

      Pages: 552-562

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590756
  • [Journal Article] Effects of insulin resistance on geranylgeranylacetone-induced expression of heat shock protein 72 and cardioprotection in high-fat diet rats.2005

    • Author(s)
      Ooie T, Kajimito M, Takahashi N, Shinohara T, Taniguchi Y, Kouno H, Wakisaka M, Yoshimatsu H, Saikawa T.
    • Journal Title

      Life Sci. 2005 77

      Pages: 869-881

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590756
  • [Journal Article] Oral administration of geranylgeranylacetone blunts the endothelial dysfunction induced by ischemia and reperfusion in the rat heart.2005

    • Author(s)
      Zhu Z, Takahashi N, Ooie T, Shinohara T, Yamanaka K, Saikawa T.
    • Journal Title

      J. Cardiovasc. Pharmacol. 45

      Pages: 555-562

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590756
  • [Journal Article] Receptor-mediated suppression of cardiac HSP72 expression by testosterone in male rat heart.

    • Author(s)
      Kohno H, Takahashi N, Shinohara T, Ooie T, Yufu K, Nakagawa M, Yonemochi H, Hara M, Saikawa T, Yoshimatsu H
    • Journal Title

      Endocrinology (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590756
  • [Journal Article] Receptor-mediated suppression of cardiac HSP72 expression by testosterone in male rat heart.

    • Author(s)
      Kohno H, Takahashi N, Shinohara T, Ooie T, Yufu K, Nakagawa M, Yonemochi H, Hara M, Saikawa T, Yoshimatsu H.
    • Journal Title

      Endocrinology (in press)

    • Data Source
      KAKENHI-PROJECT-17590756
  • [Presentation] Takahashi N. Hyperleptinemia exacerbates high fat diet-mediated atrial remodeling and fibrillation2014

    • Author(s)
      Fukui A, Kondo H, Saito S, Nishio S, Shinohara T, Teshima Y, Saikawa T
    • Organizer
      第78回日本循環器学会総会・学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23592672
  • [Presentation] Glucose fluctuations aggravate atrial fibrillation in animal models of Type 1 and Type 2 diabetes mellitus2014

    • Author(s)
      Saito S, Teshima Y, Nishio S, Kondo H, Fukui A, Nakagawa M, Saikawa T, Takahashi N
    • Organizer
      第78回日本循環器学会総会・学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23592672
  • [Presentation] Role of spleen-derived Interleukin-10 in high-fat-diet-induced inflammatory atrial fibrosis and fibrillation2014

    • Author(s)
      Kondo H, Takahashi N, Saito S, Fukui A, Nishio S, Aoki K, Shinohara T, Teshima Y, Hara M, Saikawa T
    • Organizer
      第78回日本循環器学会総会・学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23592672
  • [Presentation] Role of H1 and H2 Receptors in Pathogenesis of Pressure Overload-mediated Atrial Fibrosis and Fibrillation.2013

    • Author(s)
      Fukui A, Takahashi N, Masaki T, Konfo H, Saito S, Nishio S< Shinohara T, Teshima Y, Hara M, Saikawa T.
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23592672
  • [Presentation] Glucose Fluctuations Aggravate Cardiac Fibrosis Resulting in Worse Outcomes Including Atrial Fibrillation in Diabetic Rats.2013

    • Author(s)
      Saito S, Teshima Y, Takahashi N, Nishio S, Kondo H, Fukui A, Hara M, Nakagawa M, Saikawa T.
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23592672
  • [Presentation] Glucose Fluctuations Aggravate the Vulnerability of the Heart Against Ischemia/reperfusion Injury in Diabetic Rat2013

    • Author(s)
      Teshima Y, Takahashi N, Saito S, Kondo K, Fukui A, Nishio S, Nakagawa M, Saikawa T
    • Organizer
      第77回日本循環器学会総会学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Presentation] Calcineurin plays a key role in diabetes mellitus-induced cardiac fibrosis2013

    • Author(s)
      Nishio S, Teshima Y, Takahashi N, Saito S, Kondo K, Fukui A, Nakagawa M, Saikawa T
    • Organizer
      第77回日本循環器学会総会学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Presentation] Glucose Fluctuations in Diabetic Rats Aggravate Cardiac Fibrosis Resulting in Worse Outcomes Including Atrial Fibrillation2013

    • Author(s)
      Saito S, Teshima Y, Takahashi N, Kondo K, Fukui A, Nishio S, Nakagawa M, Saikawa T
    • Organizer
      第77回日本循環器学会総会学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Presentation] 糖尿病心筋における活性酸素種増加の機序について2012

    • Author(s)
      西尾諭、 手嶋泰之、高橋尚彦、中川幹子、犀川哲典
    • Organizer
      第52回日本臨床化学会学術集会
    • Place of Presentation
      盛岡
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Presentation] Role of Leptin Signaling in Pathogenesis of Atrial Fibrosis and Fibrillation.2012

    • Author(s)
      Fukui A, Takahashi N, Fukunaga N, Thuc L, Kume O, Miyazaki H, Wzaki K, Shinohara T, Teshima Y, Yufu K, Hara M, Nakagawa M, Yoshimatsu H, Saikawa T.
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23592672
  • [Presentation] Activation of calmodulin kinase II increases reactive oxygen species in STZ-induced diabetic rat heart2012

    • Author(s)
      Nishio S, Teshima Y, Takahashi N, Thuc LC, Saito S, Fukui A, Kume O, Nakagawa M, Saikawa T
    • Organizer
      第76回日本循環器学会総会学術集会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Presentation] 血糖値変動が心筋虚血耐性に及ぼす影響について2012

    • Author(s)
      手嶋泰之、高橋尚彦、西尾諭、江崎かおり、宮崎寛子、中川幹子、犀川哲典
    • Organizer
      第58回日本臨床検査医学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Presentation] Repeated hypoglycemia increases the vulnerability of diabetic heart against ischemia/reperfusion2012

    • Author(s)
      Thuc LC, Teshima Y, Nishio S, Fukui A, Kume O, Nakagawa M, Takahashi N, Saikawa T
    • Organizer
      第76回日本循環器学会総会学術集会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Presentation] Glucose Fluctuations Aggravate the Vulnerability of the Heart Against Ischemia/reperfusion Injury in Diabetic Rat2012

    • Author(s)
      Teshima Y, Takahashi N, Saito S, Kondo K, Fukui A, Nishio S, Nakagawa M, Saikawa T
    • Organizer
      9th IDF-WPR Congress 2012
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Presentation] Glucose fluctuations in diabetic rats aggravate cardiac fibrosis resulting in worse outcomes including atrial fibrillation2012

    • Author(s)
      Saito S, Teshima Y, Takahashi N, Fukui A, Kondo K, Nishio S, Nakagawa M, Saikawa T
    • Organizer
      第29回国際心臓研究学会(ISHR)日本部会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Presentation] 糖尿病心臓におけるカルモジュリンキナーゼを介した活性酸素種増加の機序について2012

    • Author(s)
      西尾諭、 手嶋泰之、高橋尚彦、中川幹子、犀川哲典
    • Organizer
      第22回日本病態生理学会
    • Place of Presentation
      大分
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Presentation] Calmodulin kinase II induces mitochondrial dysfunction by increasing ROS production in STZ-induced diabetic rat heart2012

    • Author(s)
      Saikawa T, Nishio S, Takahashi N, Thuc LC, Saito S, Fukui A, Kume O, Yufu K, Hara M, Nakagawa M, Teshima Y
    • Organizer
      ESC Congress 2012
    • Place of Presentation
      Munich, Germany
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Presentation] Glucose Fluctuations Aggravate the Vulnerability of Diabetic Heart Against Ischemia/reperfusion mediated via microRNAs modulation2012

    • Author(s)
      Teshima Y, Takahashi N, Thuc LC, Nishio S, Saito S, Fukui A, Kume O, Nakagawa M Saikawa T
    • Organizer
      American Heart Association Scientific Sessions 2012
    • Place of Presentation
      Los Angeles, USA
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Presentation] Activation of calmodulin kinase II by increased Na^+-H^+ exchange : as a mechanism of high glucose-induced reactive oxygen species production in cardiomyocytes2011

    • Author(s)
      Satoru Nishio, Yasushi Teshima, Tetsunori Saikawa
    • Organizer
      第75回日本循環器学会総会学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22590209
  • [Presentation] Role of Leptin Signaling in Pathogenesis of Atrial Fibrosis and Fibrillation2011

    • Author(s)
      Fukui A, Takahashi N, Teshima Y, Yufu K, Nakagawa M, Saikawa T, Kume O, Wakisaka O, Shinohara T, Hara M, Yoshimatsu H.
    • Organizer
      Annual meeting of American Heart Associatoin
    • Place of Presentation
      orlando
    • Data Source
      KAKENHI-PROJECT-23592672
  • 1.  TAKAHASHI NAOHIKO (30263239)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 27 results
  • 2.  TESHIMA Yasushi (10457608)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 29 results
  • 3.  HAGIWARA Satoshi (50527661)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  NOGUCHI Takayuki (90156183)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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