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Tsubouchi Hirohito  坪内 博仁

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TSUBOUCHI Hirohito  坪内 博仁

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Researcher Number 60145480
Other IDs
External Links
Affiliation (Current) 2022: 鹿児島大学, 医歯学総合研究科, 客員研究員
Affiliation (based on the past Project Information) *help 2014: 鹿児島大学, 医歯(薬)学総合研究科, 教授
2013 – 2014: 鹿児島大学, 医歯(薬)学総合研究科, 客員研究員
2013: 鹿児島大学, 医歯(薬)学総合研究科, 研究員
2012: 鹿児島大学, 医歯(薬)学総合研究科, 教授
2011 – 2012: 鹿児島大学, 大学院・医歯学総合研究科, 教授 … More
2010: 鹿児島大学, 医歯学総合研究科, 教授
2007 – 2009: Kagoshima University, Graduate School of Medical and Dental Sciences, Professor
2007: 鹿児島大学, 医歯(薬)学総合研究科, 教授
2006: Kagoshima University, Graduate School of Medical and Dental Sciences, Professor, 大学院医歯学総合研究科, 教授
2005: University of Kagoshima, Faculty of Medicine, professor, 医学部, 教授
2005: 鹿児島大学, 大学院・医歯学総合研究科, 教授
2003 – 2004: Miyazaki Medical College, University of Miyazaki, Department of Internal Medicine II, Professor, 医学部, 教授
2003: 宮埼医科大学, 医学部, 教授
2002: 宮崎医科大学, 医学部, 教授
1993 – 2000: 宮崎医科大学, 医学部, 教授
1991 – 1992: 鹿児島大学, 医学部, 講師
1990: 鹿児島大学, 医学部・附属病院, 助手
1988 – 1990: 鹿児島大学, 医学部附属病院, 助手
1987: the Second Department of Internal Medicine, Faculty of Medicine,Kagoshima Unived, 医学部, 助手
1986: 鹿児島大学, 医学部附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology / Hematology / 内科学一般
Except Principal Investigator
Orthodontic/Pediatric dentistry / Gastroenterology / Urology / Gastroenterology
Keywords
Principal Investigator
肝細胞増殖因子 / 肝細胞増殖因子(HGF) / HGF / 劇症肝炎 / 肝再生 / c-kit / 肝障害 / HGFmRNA / 潰瘍性大腸炎 / 炎症性腸疾患 … More / アポトーシス / 骨髄細胞 / C型慢性肝炎 / HCV / AIM / 非アルコール性脂肪肝炎 / HGF mRNA / MAPK / oval cell / 2-acethylaminofluorene / AFP / SELDI TOF / MS / 酵素免疫測定法(ELISA) / 血清hHGF値 / 早期診断 / 予後判定 / 血液悪性疾患 / G-CSF / 硫酸デキストラン(DSS) / Bcl-xL / 腸粘膜上皮幹細胞 / デキストラン硫酸(DSS) / 潰瘍性大腸炎モデルラット / 遺伝子組換えヒトHGF / 腸上皮幹細胞 / 遅発性肝不全 / プロテオーム解析 / SELDI-TOF MS / 二次元電気泳動 / 肝臓病学 / iPS細胞 / 肝細胞分化 / 上皮間葉転換 / 細胞移植 / tight juction protein / 細胞遊走 / epithelial restitution / 肺高血圧症 / 肝星細胞 / 腎メサンギウム細胞 / 臓器線維化 / 胚性幹細胞 / 肝細胞分化誘導 / マウスiPS細胞 / Dlk1 / EpCAM / 肝細胞分化誘 / マアスiPS細胞 / D1k1 / プロテオミクス / 補体C4断片 / ヒト好中球ペプチド / NAFLD / 膵炎 / 肝細胞癌 / 膵癌 / 自己免疫性膵炎 / クローン病 / 肝臓学 / セリンプロテアーゼ / 補体C4 / 断片化 / アポトーシス抑制因子 / 非アルコール性脂肪性肝疾患 / 肝線維化 / C型肝炎 / 脂肪肝 / Kupffer細胞 / HGFインデューサー / 肝疾患 / HGF産生誘導因子 / MRC-5細胞 / サイトカイン / HGF inducing factor / Liver disease / HGF activator / 急性胃粘膜傷害 / 成熟型HGF / 臓器特異性 / 肝障害モデル / 胃粘膜障害モデル / HGF ACTIVATOR / LIVER INJURY / GASTRIC MUCOSAL INJURY / 初代培養肝細胞 / 増殖因子 / サイクリンD1 / 転写調節 / 転写因子 / 肝癌細胞 / 電気遺伝子導入法 / 遺伝子発現調節 / liver regeneration / hepatocyte / growth factor / cyclin D1 / transcription / 肝幹細胞 / 70%部分肝切除 / 抗体アレイ / c-Kit / ovall cell / oval cell分化 / 肝前駆細胞 / 分化 / 細胞増殖 / Hepatocyte Growth Factor (HGF) / hepatic stem cell / 70% partial hepatectomy / antibody array / トランスクリプトーム / プロテオーム / マイクロアレイ / クリンプロット / 組み換えヒトHGF / SELDIプロテインチップ / hepatocyte growth factor (HGF) / transcriptome / proteome / microanay / ClinProt / fulminant hepatic failure / recombinant human HGF … More
Except Principal Investigator
GERD / ブラキシズム / DGOR / 増殖因子 / 肝細胞 / 細胞増殖 / 脾臓 / サイトカイン / 肝疾患 / HGF / 胃食道逆流 / RMMA / 睡眠時ブラキシズム / metron factor-1 / hepatocyte growth factor / 肝再生 / 胃食道酸逆流 / 歯周病 / 肝臓 / 癌転移 / 癌抑制因子 / トロンボポイエチン / 肝硬変 / 血小板減少症 / 免疫寛容 / 腎移植 / ミニブタ / タクロリムス / 酸 / クリアランス / 咬合 / 骨格性下顎前突 / 骨格性下顎前突症 / 8020 / 食道内pH / 咬筋筋電図 / 食道内酸刺激 / 胃酸 / 胆汁 / pH / 脳腸相関 / 顎口腔機能 / 迷走神経 / 胃 / 食道 / キメラ蛋白 / hepatocgte growth factor / 浸潤 / 転移 / liver renereration / chimera protein / 胃酸分泌抑制剤 / 唾液分泌促進剤 / プラキシズム / 顎関節症 / 口腔乾燥症 / gastro-oesophageal reflux / bruxism / acid suppressive drug / salivator / ピロリ菌 / 除菌療法 / 口臭 / gastro-oesonhaeeal reflux / sleep bruxism / Helicobacter pylori / eradication / duodenogastro-esophageal reflux / 肝細胞増殖因子 / 劇症肝炎 / 初代培養ラット肝細胞 / DNA合成 / 精製 / 成熟ラット初代培養肝細胞 / Hepatotrophic Factor / Fulminant Hepatic Failure / Primary Culture of Adult Rat Heptocytes / DNA Syrthesis / Human Hepatocyte Growth Factor Less
  • Research Projects

    (29 results)
  • Research Products

    (95 results)
  • Co-Researchers

    (45 People)
  •  Involvement of apoptosis inhibitory factor of macrophage (AIM) on pathophysiological condition of chronic liver diseasePrincipal Investigator

    • Principal Investigator
      TSUBOUCHI Hirohito
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Kagoshima University
  •  The association between stmatognathic function and the sensation of the stomach and esophagus via brain activity

    • Principal Investigator
      MIYAWAKI Shouichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Orthodontic/Pediatric dentistry
    • Research Institution
      Kagoshima University
  •  Analysis for molecular mechanism of hepatitis C virus(HCV)-induced protein associated with persistent HCV infectionPrincipal Investigator

    • Principal Investigator
      TSUBOUCHI Hirohito
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Kagoshima University
  •  Using proteomics to elucidate pathogenesis and establish new diagnostic or treatment evaluation methods in refractory gastrointestinal diseasesPrincipal Investigator

    • Principal Investigator
      TSUBOUCHI Hirohito
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Kagoshima University
  •  肝細胞増殖因子を用いたiPS細胞の肝細胞分化誘導Principal Investigator

    • Principal Investigator
      坪内 博仁
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Kagoshima University
  •  Influences of the occlusion on gastroesophageal reflux disease and acid clearance in oral cavity, pharynx and esophagus during sleep

    • Principal Investigator
      MIYAWAKI Shouichi
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Orthodontic/Pediatric dentistry
    • Research Institution
      Kagoshima University
  •  Influence of Duodeno-Gastro-Esophageal Reflux on Sleep Bruxism

    • Principal Investigator
      OMURE Haruhito
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthodontic/Pediatric dentistry
    • Research Institution
      Kagoshima University
  •  A role of hepatocyte growth factor in regulation of hepatic development and differentiationPrincipal Investigator

    • Principal Investigator
      TSUBOUCHI Hirohito
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Kagoshima University
  •  Effect of HGF on chronic changes in renal allografts in partial ly inbred miniature swine

    • Principal Investigator
      SADA Masaharu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Urology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  プロテオーム解析による劇症肝炎でのHGFの生理機能の解明と新規分子マーカーの探索Principal Investigator

    • Principal Investigator
      坪内 博仁
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Kagoshima University
  •  The effect of salivator and acid suppressive drug on bruxism-related oral disease)

    • Principal Investigator
      MIYAWAKI Shoichi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Orthodontic/Pediatric dentistry
    • Research Institution
      Kagoshima University
  •  Effect of Helicobacter pylori eradication on sleep bruxism, periodontal disease and oral malodor

    • Principal Investigator
      OHMURE Haruhito
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthodontic/Pediatric dentistry
    • Research Institution
      Kagoshima University
  •  Transcriptomic and proteomic analyses of the molecular basis of tissue repair mediated by hepatocyte growth factorPrincipal Investigator

    • Principal Investigator
      TSUBOUCHI Hirohito
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kagoshima University
  •  肝細胞増殖因子(HGF)による腸粘膜上皮幹細胞の分化・増殖と腸粘膜再生医療の試みPrincipal Investigator

    • Principal Investigator
      坪内 博仁
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      University of Miyazaki
      宮崎医科大学
  •  Development of the therapy for liver regeneration using newly-engineered chimera of HGF-MSP (Metron factor-1).

    • Principal Investigator
      TAKAHARA Terumi
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Toyama
      Toyama Medical and Pharmaceutical University
  •  Hepatocyte growth factor accelerates proliferation and differentiation of hepatic oval cells in a 2-acetylaminofluorene/partial hepatectomy model in ratPrincipal Investigator

    • Principal Investigator
      TSUBOUCHI Hirohito
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      宮崎医科大学
  •  A transcriptional factor induced by HGFPrincipal Investigator

    • Principal Investigator
      TSUBOUCHI Hirohito
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Gastroenterology
    • Research Institution
      Miyazaki Medical College
  •  肝疾患患者の血小板減少症におけるトロンボポエチンの意義

    • Principal Investigator
      林 克裕
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      宮崎医科大学
  •  Injured Tissue Specific HGF Expression and its MechanismPrincipal Investigator

    • Principal Investigator
      TSUBOUCHI Hirohito
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Miyazaki Medical College
  •  肝細胞増殖因子による血液幹細胞の分化増殖促進作用Principal Investigator

    • Principal Investigator
      坪内 博仁
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      宮崎医科大学
  •  Identification of HGF indncing factor in serum from patients with Liver diseasesPrincipal Investigator

    • Principal Investigator
      TSUBOUCHI Hirohito
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Miyazaki Medical College
  •  ヒト肝細胞増殖因子(hHGF)のin vivoにおける肝再生促進効果Principal Investigator

    • Principal Investigator
      坪内 博仁
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kagoshima University
  •  ヒト肝細胞増殖因子(hHGF)の合成・分泌調節機構

    • Principal Investigator
      大工原 恭
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kagoshima University
  •  障害肝におけるヒト肝細胞増殖因子(hHGF)のmRNAの解析Principal Investigator

    • Principal Investigator
      坪内 博仁
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kagoshima University
  •  ヒト肝細胞増殖因子(hHGF)の合成・分泌調節機構

    • Principal Investigator
      大工原 恭
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kagoshima University
  •  血清ヒト肝細胞増殖因子測定による劇症肝炎の予知Principal Investigator

    • Principal Investigator
      坪内 博仁
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kagoshima University
  •  ヒト肝細胞増殖因子の臨床応用に関する基礎的研究Principal Investigator

    • Principal Investigator
      坪内 博仁
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kagoshima University
  •  ヒト肝細胞増殖因子の産生臓器Principal Investigator

    • Principal Investigator
      坪内 博仁
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Kagoshima University
  •  The Study of the Hepatotrophic Factor in Seva from Patients with Fulminant Gepatic Failure. -its purification and clinical significarce-

    • Principal Investigator
      HASHIMOT Shuji
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kagoshima University

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent

  • [Book] Quantitative Proteome Analysis: Methods and Applications (Liver disease-related proteomics)2013

    • Author(s)
      Uto H, Takami Y, Kanmura S, Tsubouchi H
    • Publisher
      Pan Stanford Publishing Pte. Ltd
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Book] 現場の疑問に答える 肝臓病診療Q&A:我が国の劇症肝炎の実態はどうなっているのか2009

    • Author(s)
      井戸章雄, 坪内博仁
    • Total Pages
      4
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Book] 内科確定診断完全マスター:消化器系疾患:肝疾患2009

    • Author(s)
      宇都浩文, 熊谷公太郎, 坪内博仁
    • Total Pages
      10
    • Publisher
      メジカルレビュー社
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Book] 消化器研修ノート2009

    • Author(s)
      坪内博仁(編集)
    • Total Pages
      656
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Book] 【分子消化器病】HGFはどのように抗アポトーシス機構とかかおるのか?2008

    • Author(s)
      井戸章雄, 沼田政嗣, 坪内博仁.
    • Total Pages
      7
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Book] 【からだの科学】肝臓病の最新治療(1)急性肝不全に対するHGF療法2008

    • Author(s)
      井戸章雄, 坪内博仁.
    • Total Pages
      4
    • Publisher
      日本評論社
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Book] わが国の劇症肝炎の実態はどうなっているのか?. 現場の疑問に答える肝臓病診療Q&A2007

    • Author(s)
      井戸章雄, 坪内博仁
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Journal Article] Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis2015

    • Author(s)
      Yoshimine Y, Uto H, Kumagai K, Mawatari S, Arima S, Ibusuki R, Mera K, Nosaki T, Kanmura S, Numata M, Tamai T, Moriuchi A, Tsubouchi H, Ido A
    • Journal Title

      Oncol Rep

      Volume: 33 Pages: 1657-66

    • DOI

      10.3892/or.2015.3745

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670385
  • [Journal Article] Serum levels of apoptosis inhibitor of macrophage are associated with hepatic fibrosis in patients with chronic hepatitis C2014

    • Author(s)
      Mera K, Uto H, Mawatari S, Ido A, Yoshimine Y, Nosaki T, Oda K, Tabu K, Kumagai K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Hidaka M, Eguchi S, Tsubouchi H
    • Journal Title

      BMC Gastroenterology

      Volume: 14 Pages: 1-10

    • DOI

      10.1186/1471-230x-14-27

    • NAID

      120006986648

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Journal Article] Correlation of serum levels of complement C4a desArg with pathologically estimated severity of glomerular lesions and mesangial hypercellularity scores in patients with IgA nephropathy2013

    • Author(s)
      Sogabe A, Uto H, Kanmura S, Nosaki T, Oyamada M, Tokunaga K, Nishida C, Fukumoto M, Oku M, Nishimoto K, Takenouchi S, Ido A, Shimada Y, Tsubouchi H
    • Journal Title

      Int J Mol Med

      Volume: 32(2) Pages: 307-14

    • DOI

      10.3892/ijmm.2013.1390

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Journal Article] Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4.2013

    • Author(s)
      Mawatari S, Uto H, Ido A, Nakashima K, Suzuki T, Kanmura S, Kumagai K, Oda K, Tabu K, Tamai T, Moriuchi A, Oketani M, Shimada Y, Sudoh M, Shoji I, Tsubouchi H
    • Journal Title

      PLoS One

      Volume: 8(12)

    • DOI

      10.1371/journal.pone.0082094

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249043, KAKENHI-PROJECT-24390111
  • [Journal Article] Transgenic expression of human neutrophil peptide-1 enhances hepatic fibrosis in mice fed a choline-deficient, L-amino acid–defined diet.2013

    • Author(s)
      Ibusuki R, Uto H, Arima S, Mawatari S, Setoguchi Y, Iwashita Y, Hashimoto S, Maeda T, Tanoue S, Kanmura S, Oketani M, Ido A, Tsubouchi H
    • Journal Title

      Liver International

      Volume: 33(10) Pages: 1549-1556

    • DOI

      10.1111/liv.12203

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Journal Article] Serum prohepcidin levels are potential prognostic markers in patients with multiple myeloma.2012

    • Author(s)
      Haraguchi K, Uto H, Ohnou N, Tokunaga M, Tokunaga M, Utsunomiya A, Hanada S, Tsubouchi H
    • Journal Title

      Exp Ther Med.

      Volume: 4(4) Pages: 581-588

    • DOI

      10.3892/etm.2012.663

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Journal Article] The elevation of serum napsin A in idiopathic pulmonary fibrosis, compared with KL-6, surfactant protein-A and surfactant protein-D2012

    • Author(s)
      寒川卓哉、井上博雅 他
    • Journal Title

      BMC Pulm Med

      Volume: 12 Pages: 55-55

    • DOI

      10.1186/1471-2466-12-55

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390167, KAKENHI-PROJECT-23249043, KAKENHI-PROJECT-23659435, KAKENHI-PROJECT-24591172, KAKENHI-PUBLICLY-23116519
  • [Journal Article] High serum thioredoxin levels are reduced after tonsillectomy in patients with IgA nephropathy2012

    • Author(s)
      Nosaki T, Uto H, Takami Y, Oku M, Fukumoto M, Mera K, Nishida C, Tokunaga K, Sogabe A, Oketani M, Ido A, Kurono Y, Tsubouchi H
    • Journal Title

      Intern Med

      Volume: 51(6) Pages: 559-65

    • NAID

      130002061912

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Journal Article] Mastication Suppresses initial gastric emptying by modulating gastric activity2012

    • Author(s)
      Ohmure H, Takada K, Nagayama K, Sakiyama T, Tsubouchi H, Miyawaki S.
    • Journal Title

      J Dent Res

      Volume: 91 Pages: 293-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Journal Article] Human neutrophil peptide-1 aggravates dextran sulfate sodium-induced colitis.2012

    • Author(s)
      Hashimoto S, Uto H, Kanmura S, Sakiyama T, Oku M, Iwashita Y, Ibusuki R, Sasaki F, Ibusuki K, Takami Y, Moriuchi A, Oketani M, Ido A, Tsubouchi H
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 18(4) Pages: 667-675

    • DOI

      10.1002/ibd.21855

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Journal Article] Clinical features of hepatitis C virus carriers with persistently normal alanine aminotransferase levels2012

    • Author(s)
      Uto H, Mawatari S, Kumagai K, Ido A, Tsubouchi H
    • Journal Title

      Hepat Mon

      Volume: 12(2) Pages: 77-84

    • DOI

      10.5812/hepatmon.829

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Journal Article] Prevention of hepatitis B virus reactivation in patients receiving immunosuppressive therapy or chemotherapy.2012

    • Author(s)
      Oketani M, Ido A, Uto H, Tsubouchi H.
    • Journal Title

      Hepatol Res

      Volume: 42 Pages: 627-36

    • DOI

      10.1111/j.1872-034x.2012.00998.x

    • NAID

      10031144279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590742, KAKENHI-PROJECT-23249043
  • [Journal Article] Difference in serum complement component C4a levels between hepatitis C virus carriers with persistently normal alanine aminotransferase levels or chronic hepatitis C.2012

    • Author(s)
      Imakiire K, Uto H, Sato Y, Sasaki F, Mawatari S, Ido A, Shimoda K, Hayashi K, Stuver SO, Ito Y, Okanoue T, Tsubouchi H
    • Journal Title

      Mol Med Report

      Volume: 6(2) Pages: 259-2564

    • DOI

      10.3892/mmr.2012.924

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249043, KAKENHI-PROJECT-23591397
  • [Journal Article] Mastication suppresses initial gastric emptying by modulating gastric activity2012

    • Author(s)
      Ohmure H, Takada H, Nagayama K, Sakiyama T, Tsubouchi H, Miyawaki S
    • Journal Title

      JOURNAL OF DENTAL RESEARCH

      Volume: 91 Pages: 293-298

    • DOI

      10.1177/0022034511433847

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390524, KAKENHI-PROJECT-21592608, KAKENHI-PROJECT-21610016, KAKENHI-PROJECT-22659377, KAKENHI-PROJECT-23593034, KAKENHI-PROJECT-24593104
  • [Journal Article] Influence of experimental esophageal acidification on sleep bruxism : a randomized trial.2011

    • Author(s)
      Ohmure H, Oikawa K, Kanematsu K, Saito Y, Yamamoto T, Nagahama H, Tsubouchi H, Miyawaki S.
    • Journal Title

      Journal of Dental Research 90(5)

      Pages: 665-671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Journal Article] Influence of experimental esophageal acidification on sleep bruxism2011

    • Author(s)
      Ohmure H、Oikawa K、Kanematsu K、Saito Y、Yamamoto T、Nagahama H,, Tsubouchi H、Miyawaki S
    • Journal Title

      J Dent Res 90

      Pages: 665-671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592409
  • [Journal Article] Highly sensitive lens culinaris agglutinin-reactive α -fetoprotein is useful for early detection of hepatocellular carcinoma in patients with chronic liver disease2011

    • Author(s)
      Oda K, Hashiguchi T, 15番目, et al
    • Journal Title

      Oncol Rep

      Volume: 26 Pages: 1227-1233

    • DOI

      10.3892/or.2011.1425

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390179, KAKENHI-PROJECT-23249043
  • [Journal Article] Sorafenib and hepatic arterial infusion chemotherapy for unresectable advanced hepatocellular carcinoma : A comparative study2011

    • Author(s)
      Hiramine Y, Uto H, Imamura Y, Tabu K, Baba Y, Hiwaki T, Sho Y, Tahara K, Higashi H, Tamai T, Oketani M, Ido A, Tsubouchi H
    • Journal Title

      Exp Ther Med

      Volume: 2(3) Pages: 433-441

    • DOI

      10.3892/etm.2011.237

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Journal Article] Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma2011

    • Author(s)
      Tamai T, Uto H, Takami Y, Oda K, Saishoji A, Hashiguchi M, Kumagai K, Kure T, Mawatari S, Moriuchi A, Oketani M, Ido A, Tsubouchi H
    • Journal Title

      World J Gastroenterol

      Volume: 17 (44) Pages: 4890-8

    • DOI

      10.3748/wjg.v17.i44.4890

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Journal Article] Influence of Experimental Esophageal Acidification on Sleep Bnixism : a Randomized Trial.2011

    • Author(s)
      H.Ohmure, H.Tsubouchi, S.Miyawaki
    • Journal Title

      Journal of Dental Research

      Volume: 90(5) Pages: 665-671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592409
  • [Journal Article] Influence of experimental esophageal acidification on sleep bruxism2011

    • Author(s)
      Ohmure H, Oikawa K, Kanematsu K, Saito Y, Yamamoto T, Nagahama H, Tsubouchi H, Miyawaki S
    • Journal Title

      J Dent Res

      Volume: 90 Pages: 665-671

    • DOI

      10.1177/0022034510393516

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390524, KAKENHI-PROJECT-21592608, KAKENHI-PROJECT-22659377
  • [Journal Article] Influence of Experimental Esophageal Acidification on Sleep Bruxism : a Randomized Trial.2011

    • Author(s)
      H.Ohmure, H.Tsubouchi, S.Miyawaki
    • Journal Title

      Journal of Dental Research

      Volume: 90(5) Pages: 665-671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Journal Article] Influence of experimental esophageal acidification on sleep bruxism : a randomized trial2011

    • Author(s)
      Ohmure H, Oikawa K, Kanematsu K, Saito Y, Yamamoto T, Nagahama H, Tsubouchi H, Miyawaki S.
    • Journal Title

      J Dent Res

      Volume: 90 Pages: 665-71

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Journal Article] Clinical significance of alanine aminotransferase levels and the effect of ursodeoxycholic acid in hemodialysis patients with chronic hepatitis C.2010

    • Author(s)
      Nishida C, Uto H(2/11番目), Oketani M(3/11番目), Ido A(10/11番目), Tsubouchi H(11/11番目)
    • Journal Title

      J Gastroenterol 45(3)

      Pages: 326-334

    • NAID

      10027215180

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Journal Article] Proanthocyanidin derived from the leaves of Vaccinium virgatum suppresses platelet-derived growth factor-induced proliferation of the human hepatic stellate cell line LI902010

    • Author(s)
      Takami Y, Uto H(2/11番目), Oketani M(8/11番目), Ido A(9/11番目), Tsubouchi H(11/11番目)
    • Journal Title

      Hepatol Res 40(3)

      Pages: 337-345

    • NAID

      10027407999

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Journal Article] Gastroesophageal reflux symptoms in adults with skeletal Class III malocclusion examined by questionnaires2009

    • Author(s)
      Togawa R, Ohmure H, Sakaguchi K, Takada H, Oikawa K, Nagata J, Yamamoto T, Tsubouchi H, Miyawaki S.
    • Journal Title

      Am J Orthod Dentofacial Orthop

      Volume: 136(10)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Journal Article] Translational research to identify clinical applications of hepatocyte growth factor2009

    • Author(s)
      Ido A, Tsubouchi H
    • Journal Title

      Hepatol Res 39

      Pages: 739-747

    • NAID

      10025326878

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Journal Article] Gastroesophageal reflux symptoms in adults with skeletal Class III malocclusion examined by questionnaires.2009

    • Author(s)
      Togawa R, Ohmure H, Sakaguchi K, Takada H, Oikawa K, Nagata J, Yamamoto T, Tsubouchi H, Miyawaki S.
    • Journal Title

      American Journal or Orthodontics and Dentofacial Orthopedics 136(1):10

    • Data Source
      KAKENHI-PROJECT-20390524
  • [Journal Article] Gastroesophageal reflux symptoms in adults with skeletal Class III malocclusion examined by questionnaires2009

    • Author(s)
      R Togawa、H Ohmure、K Sakaguchi、H Takada、 K Oikawa、J Nagata、T Yamamoto、H Tsubouchi、S Miyawaki
    • Journal Title

      Am J Orthod Dentofacial Orthop 133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592409
  • [Journal Article] Endoscopic characterization of the small bowel in patients with portal hypertension evaluated by double balloon endoscopy.2008

    • Author(s)
      Kodama M, Uto H(2/10番目) Ido A(8/10番目), Tsubouchi H(10/10番目)
    • Journal Title

      J Gastroenterol 43(8)

      Pages: 589-596

    • NAID

      10021937551

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Journal Article] 非アルコール性脂肪肝炎(NASH)〜メタボリックシンドロームの一亜型2007

    • Author(s)
      宇都浩文、桶谷真、井戸章雄、坪内博仁
    • Journal Title

      実験医学 25

      Pages: 1375-1379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Journal Article] Alanine aminotransferase flare-up in hepatitis C virus carriers with persistently normal alanine aminotransferase levels in a hyperendemic area of Japan.2007

    • Author(s)
      Uto H(1/12番目), Ido A(6/12番目), Oketani M(11/12番目), Tsubouchi H(12/12番目)
    • Journal Title

      J Gastroenterol 42(8)

      Pages: 673-680

    • NAID

      10019817280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Journal Article] Early diagnostic potential for hepatocellular carcinoma using the SELDI ProteinChip system.2007

    • Author(s)
      Kanmura S, Uto H(2/10番目), Ido A(8/10番目), Tsubouchi H(10/10番目)
    • Journal Title

      Hepatology 45(4)

      Pages: 948-956

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Journal Article] Repeated intravenous injection of recombinant human hepatocyte growth factor ameliorates liver cirrhosis but causes albuminuria in rats.2006

    • Author(s)
      Kusumoto K,...., Tsubouchi H.
    • Journal Title

      Int J Mol Med. 17(3)

      Pages: 503-509

    • Data Source
      KAKENHI-PROJECT-17390219
  • [Journal Article] Modulation of hepatocyte growth factor induction in human skin fibroblasts by retinoic acid.2005

    • Author(s)
      Takami Y, Yamamoto I, Tsubouchi H, et al.
    • Journal Title

      Biochim Biophys Acta. 1743

      Pages: 49-56

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390230
  • [Journal Article] Development of a rapid semi-quantitative immunochromatographic assay for serum hepatocyte growth factor and its usefulness in acute liver failure.2005

    • Author(s)
      Uto H.,...., Tsubouchi H
    • Journal Title

      Hepatol Res. 33(4)

      Pages: 272-276

    • NAID

      10016809896

    • Data Source
      KAKENHI-PROJECT-17390219
  • [Journal Article] Hepatocyte growth factor facilitates the repair of large colonic ulcers in 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats.2005

    • Author(s)
      Numata M,...., Tsubouchi H
    • Journal Title

      Inflamm Bowel Dis. 11(6)

      Pages: 551-558

    • Data Source
      KAKENHI-PROJECT-17390219
  • [Journal Article] Hepatocyte growth factor accelerates the proliferation of hepatic oval cells and possibly promotes the differentiation in a 2-acetylaminofluorene/partial hepatectomy model in rats.2005

    • Author(s)
      Hasuike S,...., Tsubouchi H
    • Journal Title

      J Gastroenterol Hepatol. 20(11)

      Pages: 1753-1761

    • Data Source
      KAKENHI-PROJECT-17390219
  • [Journal Article] Possible involvement of neutrophils in a serum level increase of hepatocyte growth factor in non-Hodgkin's lymphoma.2005

    • Author(s)
      Toyama T,...., Tsubouchi H
    • Journal Title

      Oncol Rep. 13(3)

      Pages: 439-444

    • Data Source
      KAKENHI-PROJECT-17390219
  • [Journal Article] Mucosal repair and growth factors : recombinant human hepatocyte growth factor as an innovative therapy for inflammatory bowel disease.2005

    • Author(s)
      Ido A,...., Tsubouchi H
    • Journal Title

      J Gastroenterol. 40(10)

      Pages: 925-931

    • Data Source
      KAKENHI-PROJECT-17390219
  • [Patent] 血中HCV検出方法および抗HCV治療の効果判定方法2013

    • Inventor(s)
      宇都浩文、坪内博仁、馬渡誠一
    • Industrial Property Rights Holder
      宇都浩文、坪内博仁、馬渡誠一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-204395
    • Filing Date
      2013-09-18
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Patent] 血中HCV検出方法および抗HCV治療の効果判定方法2012

    • Inventor(s)
      宇都浩文, 坪内博仁, 馬渡誠一
    • Industrial Property Rights Holder
      国立大学法人, 鹿児島大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-204395
    • Filing Date
      2012-09-18
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Patent] 血中 HCV 検出方法及び抗 HCV 治療の効果判定方法2012

    • Inventor(s)
      坪内博仁、宇都浩文、馬渡誠一
    • Industrial Property Rights Holder
      国立大学法人 鹿児島大学
    • Industrial Property Number
      2012-204395
    • Filing Date
      2012-09-18
    • Data Source
      KAKENHI-PROJECT-24659371
  • [Presentation] Hepatic fibrosis and apoptosis induced by ethanol administration are exacerbated in human neutrophil peptide-1 transgenic mice2014

    • Author(s)
      Ibusuki R, Uto H, Kozono M, Oda K, Ohshige A, Kumagai K, Mawatari S, Tamai T, Moriuchi A, Oketani M, Ido A, Tsubouchi H
    • Organizer
      49th the international liver congress 2014 of the European Association for the Study of Liver Diseases (EASL)
    • Place of Presentation
      London (UK)
    • Year and Date
      2014-04-10
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Presentation] Hepatic fibrosis and apoptosis induced by ethanol administration are exacerbated in human neutrophil peptide-1 transgenic mice2014

    • Author(s)
      Rie Ibusuki, Hirofumi Uto, Masaya Kozono, Kohei Oda, Akihiko Ohshige, Kotaro Kumagai, Seiichi Mawatari, Tsutomu Tamai, Akihiro Moriuchi, Makoto Oketani, Akio Ido, HirohitoTsubouchi.
    • Organizer
      European Association for the Study of the Liver (EASL)
    • Place of Presentation
      London, UK
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Presentation] ヒト好中球ペプチド-1はアルコール性肝障害モデルマウスの肝線維化を促進する2013

    • Author(s)
      指宿りえ、宇都浩文、有馬志穂、馬渡誠一、小田耕平、大重彰彦、熊谷 公太郎、玉井 努、森内昭博、桶谷 眞、井戸章雄、坪内博仁
    • Organizer
      日本肝臓学会西部会
    • Place of Presentation
      岐阜市
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Presentation] HCV 感染者血清中に出現する補体 C4 断片は抗ウイルス治療効果の分子マーカー候補である2013

    • Author(s)
      馬渡誠一、宇都浩文、坪内博仁
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2013-03-21
    • Data Source
      KAKENHI-PROJECT-24659371
  • [Presentation] The association between serum levels of apoptosis inhibitor of macrophage and the clinical features of nonalcoholic fatty liver disease2013

    • Author(s)
      Oda K, Uto H, Mawatari S, Tabu K, Ohno K, Toyokura E, Oshige A, Imanaka D, Kumagai K, Tamai T, Moriuchi A, Oketani M, Ido A, Sumida Y, Tsubouchi H
    • Organizer
      The 64th annual meeting of the American Association for the Study of Liver Diseases (AASLD)
    • Place of Presentation
      Washington DC (USA)
    • Year and Date
      2013-11-02
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Presentation] 睡眠時ブラキシズムに対するプロトンポンプ阻害剤の効果.2013

    • Author(s)
      兼松恭子、大牟禮抬人、永山邦宏、沼田政嗣、坪内博仁、宮脇正一
    • Organizer
      第8回九州矯正歯科学会学術大会
    • Place of Presentation
      北九州市(福岡県)
    • Data Source
      KAKENHI-PROJECT-24390464
  • [Presentation] プロテオミクスから同定した非アルコール性脂肪性肝疾患の分子マーカーの臨床的意義と新しい診断法の確立2013

    • Author(s)
      宇都浩文, 岡上武, 坪内博仁
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2013-03-21
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Presentation] HCV感染者血清中に出現する補体C4断片は抗ウイルス治療効果の分子マーカー候補である2013

    • Author(s)
      馬渡誠一, 宇都浩文, 坪内博仁
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2013-03-21
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Presentation] 睡眠時ブラキシズムに対するプb・トンポンプ阻害剤の治療効果の検討:プラセボ対照二重盲検クロスオーバー比較試験.2012

    • Author(s)
      大牟禮治人、兼松恭子、永山邦宏、沼田政嗣、坪内博仁、富永和作、荒川哲男、宮脇正一
    • Organizer
      第14回日本神経消化器病学会
    • Place of Presentation
      大阪市(大阪府)
    • Year and Date
      2012-11-09
    • Data Source
      KAKENHI-PROJECT-24390464
  • [Presentation] 睡眠時ブラキシズム患者の消化器症状と内視鏡所見に関する臨床的考察2012

    • Author(s)
      兼松恭子、大牟禮治人、迫口陽子、嵜山敏男、坪内博仁、宮脇正一
    • Organizer
      第7回九州矯正歯科学会大会
    • Place of Presentation
      別府国際コンベンションセンター(大分県)
    • Year and Date
      2012-02-05
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] 食道内への酸刺激が覚醒時の咀嚼筋活動に及ぼす影響2012

    • Author(s)
      迫口陽子、大牟禮治人、高田寛子、嵜山敏男、坪内博仁、宮脇正一
    • Organizer
      第7回九州矯正歯科学会学術大会学術口演
    • Place of Presentation
      大分
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] Hepatitis C virus NS3/4A protease inhibits complement activation through cleavage of complement component C42012

    • Author(s)
      Mawatari S, Uto H, Kumagai K, Oda K, Tabu K, Ohno K, Oshige A, Imanaka D, Tamai T, Moriuchi A, Oketani M, Ido A, Tsubouchi H, Sato Y, Suzuki T
    • Organizer
      The 63th annual meeting of the AASLD
    • Place of Presentation
      Boston(USA)
    • Year and Date
      2012-11-11
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Presentation] 睡眠時ブラキシズム患者の消化器症状と内視鏡所見に関する臨床的考察2012

    • Author(s)
      兼松恭子、大牟禮治人、迫口陽子、嵜山敏男、坪内博仁、宮脇正一
    • Organizer
      第7回九州矯正歯科学会学術大会学術展示
    • Place of Presentation
      大分
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] 食道内への酸刺激が覚醒時の咀嚼筋活動に及ぼす影響2012

    • Author(s)
      迫口陽子、大牟禮治人、高田寛子、嵜山敏男、坪内博仁、宮脇正一
    • Organizer
      第7回九州矯正歯科学会大会
    • Place of Presentation
      別府国際コンベンションセンター(大分県)
    • Year and Date
      2012-02-05
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] Hepatitis C virus NS3/4A protease inhibits complement activation through cleavage of complement component C42012

    • Author(s)
      Mawatari S, Uto H, Sato Y, Kumagai K, Oda K, Tabu K, Tamai T, Moriuchi A, Oketani M, Ido A, Suzuki T, Tsubouchi H
    • Organizer
      The 63th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston, MA, USA
    • Data Source
      KAKENHI-PROJECT-24659371
  • [Presentation] Serum levels of apoptosis inhibitor of macrophage (AIM) are associated with hepatic fibrosis and insulin resistance in patients with hepatitis C virus-associated liver disease2012

    • Author(s)
      Mera K, Uto H, Sato Y, Yoshimine Y, Oda K, Imanaka D, Saishoji A, Tamai T, Nosaki T, Moriuchi A, Oketani M, Ido A, Tsubouchi H
    • Organizer
      Digestive Disease Week (DDW)
    • Place of Presentation
      Sandiego (USA)
    • Year and Date
      2012-05-19
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Presentation] Human neutrophil peptide-1 aggravates hepatic fibrosis in a nonalcoholic steatohepatitis mouse model2011

    • Author(s)
      Ibusuki R, Uto H, Arima S, Mawatari S, Iwashita Y, Hashimoto S, Maeda T, Tamai T, Moriuchi A, Setoguchi Y, Oketani M, Ido A, Tsubouchi H
    • Organizer
      The 62th annual meeting of the AASLD
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2011-11-05
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Presentation] 咀嚼は胃の活動を一過性に抑制しその後増大させる2011

    • Author(s)
      大牟禮治人、高田寛子、永山邦宏、嵜山敏男、坪内博仁、宮脇正一
    • Organizer
      第13回日本神経消化器病学会
    • Place of Presentation
      栃木県総合文化センター(栃木県)
    • Year and Date
      2011-11-05
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] Human neutrophil peptide-1はTリンパ球非依存的にDSS腸炎を悪化させる2011

    • Author(s)
      橋元慎一, 宇都浩文, 坪内博仁
    • Organizer
      第53回日本消化器病学会大会
    • Place of Presentation
      福岡市
    • Year and Date
      2011-10-21
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Presentation] ヒト好中球ペプチド-1はNASH動物モデルの肝線維化を促進する2011

    • Author(s)
      宇都浩文, 指宿りえ, 坪内博仁
    • Organizer
      第15回日本肝臓学会大会
    • Place of Presentation
      福岡市
    • Year and Date
      2011-10-20
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Presentation] 肝癌患者血清を用いたプロテオミクスで同定したApoptosisInhibitorofMacrophage(AIM)の病態への関与2011

    • Author(s)
      宇都浩文, 米良久美子, 坪内博仁
    • Organizer
      第39回日本肝臓学会西部会
    • Place of Presentation
      岡山市
    • Year and Date
      2011-12-09
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Presentation] 肝癌患者血清を用いたプロテオミクスで同定したApoptosis Inhibitor of Macrophage (AIM)の病態への関与2011

    • Author(s)
      宇都浩文、米良久美子、坪内博仁
    • Organizer
      第39回日本肝臓学会西部会
    • Place of Presentation
      岡山市
    • Year and Date
      2011-12-09
    • Data Source
      KAKENHI-PROJECT-23249043
  • [Presentation] 咀嚼は胃の活動を一過性に抑制しその後増大させる2011

    • Author(s)
      大牟禮治人、高田寛子、永山邦宏、嵜山敏男、坪内博仁、宮脇正一
    • Organizer
      第13回日本神経消化器病学会学術大会学術口演
    • Place of Presentation
      宇都宮
    • Year and Date
      2011-11-05
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] 咀嚼が胃排出能に及ぼす影響-上部消化管機能との関連-2011

    • Author(s)
      高田寛子、大牟禮治人、永山邦宏、嵜山敏男、坪内博仁、宮脇正一
    • Organizer
      第70回日本矯正歯科学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] 咀嚼が胃排出能に及ぼす影響-上部消化管機能との関連-2011

    • Author(s)
      高田寛子、大牟禮治人、永山邦宏、嵜山敏男、坪内博仁、宮脇正一
    • Organizer
      第70回日本矯正歯科学会学術大会学術展示
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] 食道内への酸刺激が覚醒時の咀嚼筋活動に及ぼす影響2011

    • Author(s)
      齋藤陽子、大牟禮治人、兼松恭子、嵜山敏男、坪内博仁、宮脇正一
    • Organizer
      第70回日本矯正歯科学会学術大会学術口演
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] 肝炎診療の進歩と展望2010

    • Author(s)
      坪内博仁
    • Organizer
      第110回九州医師会医学会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2010-11-13
    • Data Source
      KAKENHI-PROJECT-21659190
  • [Presentation] 睡眠時の咀嚼筋活動と食道内の酸クリアランスとの関係2010

    • Author(s)
      及川紀佳子,大牟禮治人,高田寛子,斎藤陽子,兼松恭子,山元隆文,坪内博仁,宮脇正一
    • Organizer
      第5回九州矯正歯科学会学術大会(九州矯正歯科学会)
    • Place of Presentation
      鹿児島市
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] 劇症肝炎の現況とde novoB型肝炎2010

    • Author(s)
      坪内博仁
    • Organizer
      第56回東北支部生涯教育講演会
    • Place of Presentation
      仙台市
    • Year and Date
      2010-06-19
    • Data Source
      KAKENHI-PROJECT-21659190
  • [Presentation] 肝硬変の治療2010

    • Author(s)
      坪内博仁
    • Organizer
      第107回日本内科学会総会・講演会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-09
    • Data Source
      KAKENHI-PROJECT-21659190
  • [Presentation] 睡眠時の咀嚼筋活動と食道内の酸クリアランスとの関係2010

    • Author(s)
      及川紀佳子、大牟禮治人、高田寛子、斎藤陽子、兼松恭子、山元隆文、坪内博仁、宮脇正一
    • Organizer
      第5回九州矯正歯科学会学術大会学術展示
    • Place of Presentation
      鹿児島
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] 生活習慣病としての肝臓病2010

    • Author(s)
      坪内博仁
    • Organizer
      2010年度日本内科学会生涯教育講演会(Aセッション)第2回
    • Place of Presentation
      横浜市
    • Year and Date
      2010-05-30
    • Data Source
      KAKENHI-PROJECT-21659190
  • [Presentation] 睡眠時の食道内への繰り返しの酸刺激が咀嚼筋活動に及ぼす影響2009

    • Author(s)
      及川紀佳子,大牟禮治人,高田寛子,斎藤陽子,兼松恭子,長濱博行,坪内博仁,宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会(日本矯正歯科学会)
    • Place of Presentation
      福岡市
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] 睡眠時の食道内への繰り返しの酸刺激が咀嚼筋活動に及ぼす影響2009

    • Author(s)
      及川紀佳子、大牟禮治人、高田寛子、斎藤陽子、兼松恭子、長濱博行、坪内博仁、宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会学術展
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] 睡眠時の食道内への酸の注入がブラキシズムの発現に及ぼす影響2009

    • Author(s)
      大牟禮治人、及川紀佳子、兼松恭子、北嶋文哲、楠本順哉、山元隆文、坪内博仁、宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会学術展示
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] Clinical Significance of Alanine Aminotransferase Livels and Effect of Ursodeoxycholic Acid in Hemodialysis Patients with Chronic Hepatitis c.2009

    • Author(s)
      Nishida C, Uto H, Tokunaga K, Fukumoto M, Sogabe A, Nosaki T, Moriuchi A, Oketani M, Ido A, Tsubouchi H
    • Organizer
      19th Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Hong Kong
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Presentation] 睡眠時の食道内への酸の注入がブラキシズムの発現に及ぼす影響2009

    • Author(s)
      大牟禮治人,及川紀佳子,兼松恭子,北嶋文哲,楠本順哉,山元隆文,坪内博仁,宮脇正一
    • Organizer
      第68回日本矯正歯科学会学術大会(日本矯正歯科学会)
    • Place of Presentation
      福岡市:優秀発表賞受賞
    • Data Source
      KAKENHI-PROJECT-20390524
  • [Presentation] A fragment of high molecular weight kininogen is upregulated in patients with non-alcoholic fatty liver diserse2008

    • Author(s)
      Uto H, Sato Y, Tanoue S, Ishida Y, Tamai T, Hasegawa S, Oketani M, Ido A, Nakajima T, Okanoue T, Tsubouchi H
    • Organizer
      59th Annual Meeting of American Association for the Study of Live Diseas
    • Place of Presentation
      San Francisco
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Presentation] Trasnlational research of HGF: A phaseI/IIstudy of recombinant human HGF for the treatment of fulminant hepatic failure2007

    • Author(s)
      Ido A, Moriuchi A, Marusawa H, Ikeda K, Numata M, Yamaji N, Setoyama H, Ida H, Oketani M, Chiba T, Tsubouchi H
    • Organizer
      6th JSH Single Topic Conferens "Liver Failure:Recent Progress from Pathogenesis to Management"
    • Place of Presentation
      安比市
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Presentation] Proteomic analysis of serum biomarkers in patients with nonalcoholic steatohepatitis using SEDI-TOF/MS or MALDI-TOF/MS2007

    • Author(s)
      Uto H, Sato Y, Ishida Y, Takami Y, Kanmura S, Moriuchi A, Hasegawa S, Oketani M, Ido A, Nakajima T, Okanoue T, Tsubouchi H
    • Organizer
      The 58th Annual Meeting of the American Association for the Study of the Live Disease
    • Place of Presentation
      Boston
    • Data Source
      KAKENHI-PROJECT-19209028
  • [Presentation] 非アルコール性脂肪性肝疾患におけるApoptosis Inhibitor of Macrophage(AIM)の臨床的意義

    • Author(s)
      小田耕平、宇都浩文、角田圭雄、馬渡誠一、大西容雅、坂江遥、室町香織、椨 恵理子、大重彰彦、玉井努、森内昭博、岡上武、坪内博仁、井戸章雄
    • Organizer
      第51回 日本消化器免疫学会総会
    • Place of Presentation
      京都(京都大学医学部 芝蘭会館)
    • Year and Date
      2014-07-10 – 2014-07-11
    • Data Source
      KAKENHI-PROJECT-26670385
  • [Presentation] HCV感染者血清中に出現する補体C4断片は抗ウイルス治療効果の分子マーカー候補である

    • Author(s)
      馬渡誠一、宇都浩文、坪内博仁
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島市
    • Data Source
      KAKENHI-PROJECT-24659371
  • [Presentation] Serum levels of apoptosis inhibitor of macrophage (AIM) are associated with hepatic fibrosis and insulin resistance in patients with nonalcoholic fatty liver disease

    • Author(s)
      Kohei Oda, Hirofumi Uto, Yoshio Sumida, Takeshi Okanoue, Seiichi Mawatari, Hiroka Onishi, Haruka Sakae, Kaori Muromachi, Eriko Tabu, Akihiko Oshige, Dai Imanaka, Tsutomu Tamai, Akihiro Moriuchi, Hirohito Tsubouchi, Akio Ido
    • Organizer
      THE LIVER MEETING 2014 - AASLD, 65th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston, MA, USA(John B. Hynes Veterans Memorial Convention Center)
    • Year and Date
      2014-11-07 – 2014-11-11
    • Data Source
      KAKENHI-PROJECT-26670385
  • [Presentation] 非アルコール性脂肪性肝疾患の病態におけるApoptosis Inhibitor of Macrophageの意義

    • Author(s)
      小田耕平、宇都浩文、馬渡誠一、指宿りえ、椨一晃、大野香織、椨恵理子、大重彰彦、今中大、熊谷公太郎、玉井努、森内昭博、桶谷真、井戸章雄、角田圭雄、岡上武、坪内博仁
    • Organizer
      第50回 日本肝臓学会総会
    • Place of Presentation
      東京(ホテルニューオータニ)
    • Year and Date
      2014-05-29 – 2015-05-30
    • Data Source
      KAKENHI-PROJECT-26670385
  • [Presentation] アポトーシス抑制因子AIMは非アルコール性脂肪性肝疾患の病態と関連する

    • Author(s)
      小田耕平、宇都浩文、角田圭雄、馬渡誠一、椨一晃、椨恵理子、室町香織、大重彰彦、熊谷公太郎、玉井努、森内昭博、桶谷眞、坪内博仁、井戸章雄
    • Organizer
      第103回 日本消化器病学会九州支部例会
    • Place of Presentation
      福岡(アクロス福岡)
    • Year and Date
      2014-07-04 – 2014-07-05
    • Data Source
      KAKENHI-PROJECT-26670385
  • 1.  UTO Hirofumi (20347058)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 47 results
  • 2.  IDO Akio (30291545)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 34 results
  • 3.  OHMURE Haruhito (00404484)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 28 results
  • 4.  MIYAWAKI Shouichi (80295807)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 28 results
  • 5.  HIRONO Shuichi (00181222)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  OKETANI Makoto (50274816)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  NAGATA Junko (50264429)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 8.  YAMAMOTO Takafumi (00457649)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 9.  UEDA Hirotaka (10583445)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  NAGAYAMA Kunihiro (60583458)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 11.  NAKAYAMA Hiroyuki (00172479)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  大工原 恭 (40028733)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  中河 志朗 (70073666)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  新垣 尚捷 (60151148)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  SADA Masaharu (20162399)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  YAMADA Kazuhiko (40241103)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  SAKAGUCHI Katsuyoshi (80381185)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 18.  YAGI Takakazu (10346166)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  MAEDA Aya (10457666)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  UEHARA Sawako (50706257)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  SAKIYAMA Toshio (70542421)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  IBUSUKI Rie (90747015)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 23.  KITAMURA Tooru (30169883)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  TAKAHARA Terumi (60240777)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  MINEMURA Masami (10313602)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  HASUIKE Satoru (50381067)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 27.  YAMASAKI Youichi (30200645)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  HASHIMOT Shuji (30041271)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  松岡 均 (30219406)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  林 克裕 (10136806)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  清水 章 (00256942)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  野崎 剛 (00433087)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  福永 智広 (70362994)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  森内 昭博 (40359823)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  北村 和生 (10234288)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  和泉 雄一 (60159803)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  瀬戸口 尚志 (60206646)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  小椋 幹記 (40194526)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  馬渡 誠一
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 40.  桶谷 真
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 24 results
  • 41.  井上 博雅
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 42.  橋口 照人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 43.  鈴木 亮介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 44.  鈴木 哲朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 45.  下田 和哉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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