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MAKINO Naoki  牧野 直樹

ORCIDConnect your ORCID iD *help
Researcher Number 60157170
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2014: 九州大学病院別府病院, 内科, 名誉教授
2011 – 2014: 九州大学, 大学病院, 教授
2013: 九州大学病院, 別府病院, 教授
2008 – 2010: 九州大学, 生体防御医学研究所, 教授
2005 – 2006: 九州大学, 生体防御医学研究所, 教授 … More
1999 – 2003: Medical Institute of Bioregulation Kyushu University Professor, 生体防御医学研究所, 教授
1995 – 1998: 九州大学, 生体防御医学研究所, 助教授
1990 – 1992: Kyushu University, Bioclimatology and Medicine Medical Institute of Bioregulation Associated Professor, 生体防御医学研究所, 助教授
1987 – 1989: 九州大学, 生体防御医学研究所, 講師 Less
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine / Circulatory organs internal medicine
Except Principal Investigator
Circulatory organs internal medicine / General internal medicine (including Psychosomatic medicine) / Circulatory organs internal medicine
Keywords
Principal Investigator
MMP / PPAR-r / myocardial infarction / matrix metaloproteinase / 心筋梗塞 / 遺伝子治療 / 心筋肥大 / アンギオテンシン転換酵素阻害剤 / 遺伝子発現 / コラーゲン … More / alpha1-adrenoceptors / cardiac regression / cardiac hypertrophy / rat heart / heart sarcolemma / [5-methyl-^3H] nitrendipine binding / calcium ion pump / sodium-calcium ion exchange / 心筋細胞膜 / カルシウム / 膜イオン輸送 / Na^+K^+ーATPase / 膜リン脂質 / Ca^<2+>ポンプ / Na^+ーCa^<2+>交換 / 自然発症型高血圧ラット / 心筋肥大退縮 / ベ-タ-遮断剤 / アルファ-遮断剤 / カテコラミン受容体 / 自然発症高血圧ラット / ラット / 肥大退縮 / 膜脂質代謝 / アドレナリン受容体 / カルシウム代謝 / 圧負荷肥大心 / gene therapy / remodeling / tyrosine phosphorylation / angiogenesis / 血管新生療法 / SiRNA / SHP-1 / 血管内皮増殖因子 / リモデリング / チロシンリン酸化 / 血管新生 / NFκ-B / Cytokines / Brain Natriuretic Peptide / Cardiac Remodeling / TIMP / TNF-alpha / 心筋細胞 / 低酸素 / マトリックスメタロプロテアーゼ / NFk-b / サイトカイン / BNP / 心筋リモデリング / Tissue Necrosis Factor / Myocardial Fibrosis / Extracellular Matrix / メタロプロテアーゼ / TNFα / 心筋線維化 / 細胞外マトリックス / HYPERTROPHY / SHR / GENE THERAPY / ANGIOTENSINOGEN / アンジオテンシノーゲン / アンチセンス / NEBULIN / GENE EXPRESSION / HEART / 心房 / ネブリン / 心臓 / Enalapril / Angiotensin converting enzyme inhibitor / Gene expression / Myocardial damage / Immunohistochemistry / Fibronectin / Collagen, / Cardiomyopathic hamster / フイブロネクチン / コラ-ゲン / 心筋症ハムスタ- / エナラプリル / 免疫組織化学 / 心筋障害 / 免疫細織化学 / フィブロネクチン / 心筋症ハムスター … More
Except Principal Investigator
MRI / 心筋梗塞 / サイトカイン / 血管内皮細胞 / 老化 / テロメア / Sudden death / Periodic Variation / Bradyarrhythmias / Catecholamine / Acoustic stimuli / 致死性不整脈 / 細胞内Ca蓄積 / 左心房 / ジギタリスリセプター / 細胞膜心室細動 / 多現象記録 / カフェイン / ジギタリス / 不整脈の周期性変動 / 不整脈の自然変動 / カテコラミン / 長時間連続心電図記録 / テレメトリー / Ca拮抗剤 / カテコールアミン / 急死 / 徐脈性不整脈 / 音刺激 / 自然変動 / 不整脈 / Aging / Relaxation time / Muscle / 速筋 / 緩和時間 / 加齢 / 筋肉 / Myocardial infarction / Endothelial cells / Angiogenesis / Apoptosis / Soluble TNF receptor 1 / Tumor necrosis factor / 酸化LDL / TNF-alphaレセプタ-1 / 血管新生 / アポトーシス / soluble TNF receptor 1 / 腫瘍壊死因子(TNF) / AT1 Blocker / MyocarDial Infarction / Collagen / Matrix Metalloproteinase / Extracellular Mtrix / Cardiac Remodeling / ATI拮抗薬 / 心筋再構築 / コラーゲン / マトリックス・メタロプロテアーゼ / 細胞外マトリックス / Rat / Perfused Heart / Freeradical Scavenger / Sodium / Calcium / Free Radical / Cardiac Damage / Reperfusion / 灌流ラット心 / Na^+-K ATPase / 再灌流不整脈 / 心筋カルシウム / 心筋細胞膜 / 膜脂質過酸化 / 潅流ラット心 / 活性酸素 / Na^+ーK ATPaes / ラット心臓 / 活性酸素消去剤 / 腫瘍壊死因子 / インタ-ワイキン1 / 再潅流障害 / ラット / 摘出潅流心 / フリ-ラジカル消去剤 / フリ-ラジカル / カルシウム代謝 / 再潅流不整脈 / 再潅流心筋障害 / 近赤外線レーザー / 心臓局所温熱 / トランスジェニックマウス / ナノテクノロジー / 循環器 / 温熱療法 / 心不全 / 金ナノロッド / 白血球 / 環状DNA / DNA組換え / 慢性疾患 / DNAメチル化 / サブテロメア Less
  • Research Projects

    (15 results)
  • Research Products

    (118 results)
  • Co-Researchers

    (24 People)
  •  Targeted heart hyperthermia for heart failure using gold nano-rod

    • Principal Investigator
      HIGUCHI Yoshihiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kyushu University
  •  The evaluation of genomic aging by quantifying telomeric circular DNA in peripheral leukocytes of patients with chronic disease.

    • Principal Investigator
      MAEDA Toyoki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      Kyushu University
  •  The relationship between telomere attrition and the subtelomeric methylation of peripheral leukocytes

    • Principal Investigator
      MAEDA Toyoki
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      Kyushu University
  •  Role of Tyrosine Dephosphorylation on Angiogenesis in Remodeling after Myocardial IschemiaPrincipal Investigator

    • Principal Investigator
      MAKINO Naoki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      KYUSHU UNIVERCITY
  •  Matrix Degradative Enzyme Activities on Cardiac Remodeling in Heart FailurePrincipal Investigator

    • Principal Investigator
      MAKINO Naoki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kyushu University
  •  Development of new gene therapy for treatment of atherosclerosis using anti-apoptotic genes

    • Principal Investigator
      SUGANO Masahiro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      KYUSHU UNIVERSITY
  •  New approach for evaluating muscle function by using MR imaging

    • Principal Investigator
      HATAKENAKA Masamitsu
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Institution
      KYUSHU UNIVERSITY
  •  Regulation of Synthesis and Degradation of Extracellular Matrix in Acute Myocardial InfarctionPrincipal Investigator

    • Principal Investigator
      MAKINO Naoki, 畑 知二
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      KYUSHU UNIVERSITY
  •  Chronic Effects of Antisense Oligodeoxynucleotides Against Angiotensinogen on Cardiac Remodeling in Spontaneously Hypertensive RatsPrincipal Investigator

    • Principal Investigator
      MAKINO Naoki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      KYUSHU UNIVERSITY
  •  Investigation of Extracellular Matrix Synthesis and Degradation after Myocardial Infarction.

    • Principal Investigator
      HATA Tomoji
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      KYUSHU UNIVERSITY
  •  POSITION SPECIFIC GENE EXPRESSION IN HEARTPrincipal Investigator

    • Principal Investigator
      MAKINO Naoki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      KYUSHU UNIVERSITY
  •  STUDIES OF PATHOPHYSIOLOGICAL AND BIOCHEMICAL ASPECTS ON THE DEVELOPMENT OF CARDIOMYOPATHIC HAMSTERSPrincipal Investigator

    • Principal Investigator
      MAKINO Naoki
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      KYUSHU UNIVERSITY
  •  Role of Calcium and Protective Effects on Reperfusion Cardiac Damages

    • Principal Investigator
      YANAGA Takashi
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kyushu University
  •  Sarcolemmal Ion Transport in Pressure Induced Cardiac HypertrophyPrincipal Investigator

    • Principal Investigator
      MAKINO Naoki
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kyushu University
  •  Mechanism of appearance of periodic variation of arrhythmias

    • Principal Investigator
      TAKASHI YANAGA
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kyushu University

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation

  • [Journal Article] X-irradiation alters the telomerase activity and the telomere length distribution of cultured human vascular endothelial cells2014

    • Author(s)
      Toyoki Maeda, Jing-Zhi Guan, Masamichi Koyanagi, Naoki Makino
    • Journal Title

      Appl Cell Biol

      Volume: 3

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Vascular endothelial cell surviving through under prolonged elevated temperature shows persistent or transient up-regulation of telomerase and stress-associated proteins2014

    • Author(s)
      Toyoki Maeda, Jing-Zhi Guan, Masamichi Koyanagi, Naoki Makino
    • Journal Title

      Appl Cell Biol

      Volume: 2

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] X-irradiation alters the telomerase activity and the telomere length distribution of cultured human vascular endothelial cells.2014

    • Author(s)
      Toyoki Maeda1, Jing-Zhi Guan, Masamichi Koyanagi, Naoki Makino.
    • Journal Title

      Appl Cell Biol

      Volume: 3 Pages: 0-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Vascular endothelial cell surviving through under prolonged elevated temperature shows persistent or transient up-regulation of telomerase and stress-associated proteins.2014

    • Author(s)
      Toyoki Maeda1, Jing-Zhi Guan, Masamichi Koyanagi, Naoki Makino.
    • Journal Title

      Appl Cell Biol

      Volume: 3 Pages: 0-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Hyperthermia by bathing in a hot spring improves cardiovascular functions and reduces the production of inflammatory cytokines in patients with chronic heart failure.2013

    • Author(s)
      Oyama J, Kudo Y, Maeda T, Node K, Makino N.
    • Journal Title

      Heart Vessels.

      Volume: 28 Issue: 2 Pages: 173-178

    • DOI

      10.1007/s00380-011-0220-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Analysis of telomere length and subtelomeric methylation of circulating leucocytes in female patients with Alzheimer's disease2013

    • Author(s)
      J-Z. Guan, T. Maeda N. Makino
    • Journal Title

      Aging Clin Exp Res

      Volume: 25 Pages: 17-23

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Telomerase activity and telomere length distribution in vascular endothelial cell in a short-term culture under the presence of hydrogen peroxide2013

    • Author(s)
      Maeda T, Jing-Zhi Guan, Koyanagi M, Makino N
    • Journal Title

      Geriatrics and Gerontology International

      Volume: 13 Pages: 774-782

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Alterations in the telomere length distribution and the subtelomeric methylation status in human vascular endothelial cells under elevated temperature in culture condition2013

    • Author(s)
      Maeda T, G. Jing-Zhi, Koyanagi M Makino N
    • Journal Title

      Aging Clin Exp Res

      Volume: 25 Pages: 231-238

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Alterations in the telomere length distribution and the subtelomeric methylation status in human vascular endothelial cells under elevated temperature in culture condition.2013

    • Author(s)
      Maeda T, Guan JZ, Koyanagi M, Makino N.
    • Journal Title

      Aging Clin Exp Res.

      Volume: 25 Issue: 3 Pages: 231-238

    • DOI

      10.1007/s40520-013-0045-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590885, KAKENHI-PROJECT-23591083
  • [Journal Article] Telomerase activity and telomere length distribution in vascular endothelial cells in a short-term culture under the presence of hydrogen peroxide.2013

    • Author(s)
      Maeda T, Guan JZ, Koyanagi M, Makino N.
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 13 Issue: 3 Pages: 774-782

    • DOI

      10.1111/j.1447-0594.2012.00936.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Hyperthermia by bathing in a hot spring improves the cardiovascular functions and reduces the production of inflammatory cytokines in patients with chronic heart failure2013

    • Author(s)
      Jun-ichi Oyama, Yoshihiro Kudo, Toyoki Maeda, Koichi Node, Naoki Makino
    • Journal Title

      Heart and Vessels

      Volume: 13 Pages: 774-782

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Analysis of telomere length and subtelomeric methylation of circulating leukocytes in women with Alzheimer's disease.2013

    • Author(s)
      Guan JZ, Guan WP, Maeda T, Makino N.
    • Journal Title

      Aging Clin Exp Res.

      Volume: 25 Issue: 1 Pages: 17-23

    • DOI

      10.1007/s40520-013-0006-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Different levels of hypoxia regulate telomere length and telomerase activity2012

    • Author(s)
      Jing-Zhi Guan, Wei-Ping Guan, Toyoki Maeda, Naoki Makino
    • Journal Title

      Aging Clin Exp Res

      Volume: 24 Pages: 213-217

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Continuous Positive Airway Pressure Therapy Improves Vascular Dysfunction and Decreases Oxidative Stress in Patients With the Metabolic Syndrome and Obstructive Sleep Apnea Syndrome2012

    • Author(s)
      Oyama JI, Yamamoto H, Maeda T, Ito A, Node K, Makino N
    • Journal Title

      Clin Cardiol

      Volume: 35 Pages: 15-20

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Aging-associated alteration of telomere length and subtelomeric status in female patients with Parkinson's disease.2012

    • Author(s)
      Maeda T, Guan JZ, Koyanagi M, Higuchi Y, Makino N.
    • Journal Title

      Journal of Neurogenetics

      Volume: 26 Issue: 2 Pages: 245-251

    • DOI

      10.3109/01677063.2011.651665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590885, KAKENHI-PROJECT-23591083
  • [Journal Article] Alteration of telomere length and subtelomeric methylation in human endothelial cell under different levels of hypoxia.2012

    • Author(s)
      Guan JZ, Guan WP, Maeda T, Makino N.
    • Journal Title

      Archives of Medical Research

      Volume: 43 Issue: 1 Pages: 15-20

    • DOI

      10.1016/j.arcmed.2012.02.001

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Upregulation of anticoagulant proteins, protein S and tissue factor pathway inhibitor, in the mouse myocardium with cardio-specific TNF-alpha overexpression2012

    • Author(s)
      Higuchi Y, Kubota T, Koyanagi M, Maeda T, Feldman AM, Makino N.
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 302(11) Issue: 11 Pages: H2352-H2362

    • DOI

      10.1152/ajpheart.01026.2011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591083, KAKENHI-PROJECT-24591098
  • [Journal Article] Repetitive hyperthermia attenuates progression of left ventricular hypertrophy and increases telomerase activity in hypertensive rats.2012

    • Author(s)
      Oyama J, Maeda T, Sasaki M, Higuchi Y, Node K, Makino N.
    • Journal Title

      American Journal of Physiology Heart Circulation Physiology

      Volume: 302 Issue: 10 Pages: 2092-2101

    • DOI

      10.1152/ajpheart.00225.2011

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Radiation- associated telomere length changes of peripheral leukocytes of inpatients with cancer International2012

    • Author(s)
      Toyoki Maeda, Katsumasa Nakamura, Kazushige Atsumi, Masakazu Hirakawa, Yasuko Ueda, Naoki Makino
    • Journal Title

      Journal of Radiation Biology

      Volume: 89 Pages: 106-109

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Effect of vitamin E administration on the elevated oxygen stress and the telomeric and subtelomeric status in Alzheimer's disease.2012

    • Author(s)
      Guan JZ, Guan WP, Maeda T, Makino N.
    • Journal Title

      Gerontology

      Volume: 58 Issue: 1 Pages: 62-69

    • DOI

      10.1159/000327821

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Alteration of telomere length and subtelomeric methylation in human endothelial cell under different levels of hypoxia2012

    • Author(s)
      Jing-Zhi Guan, Wei-Ping Guan, Toyoki Maeda, Naoki Makino
    • Journal Title

      Archives of Medical Research

      Volume: 43 Pages: 15-20

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Repetitive hyperthermia attenuates progression of left ventricular hypertrophy and increases telomerase activity in hypertensive rats2012

    • Author(s)
      Oyama JI, Maeda T, Sasaki M, Higuchi Y, Node K, Makino N
    • Journal Title

      Am J Physiol-Heart Circ Physiol

      Volume: 302

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Continuous positive airway pressure therapy improves vascular dysfunction and decreases oxidative stress in patients with the metabolic syndrome and obstructive sleep apnea syndrome.2012

    • Author(s)
      Oyama J, Yamamoto H, Maeda T, Ito A, Node K, Makino N.
    • Journal Title

      Clinical Cardiolology

      Volume: 35 Issue: 4 Pages: 231-236

    • DOI

      10.1002/clc.21010

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] The Subtelomere of Short Telomeres is Hypermethylated in Alzheimer's Disease.2012

    • Author(s)
      Guan JZ, Guan WP, Maeda T, Makino N.
    • Journal Title

      Aging and Disease

      Volume: 3 Pages: 164-170

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Upregulation of Anticoagulant Proteins, Protein S and Tissue Factor Pathway Inhibitor, in the Mouse Myocardium with Cardio-Specific TNF- x03B1; Overexpression2012

    • Author(s)
      Yosihiro Higuchi, Masamichi Koyanagi, Toru Kubota, Toyoki Maeda, Arthur Feldman, Naoki Makino
    • Journal Title

      Am J Physiol-Heart Circ Physiol

      Volume: 302

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Different levels of hypoxia regulate telomere length and telomerase activity.2012

    • Author(s)
      Guan JZ, Guan WP, Maeda T, Makino.
    • Journal Title

      Aging Clin Exp Res

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Different levels of hypoxia regulate telomere length and telomerase activity.2012

    • Author(s)
      Guan JZ, Guan WP, Maeda T, Makino N.
    • Journal Title

      Aging and Clinical Experimental Research

      Volume: 24 Pages: 213-217

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] The gender-related alterations in the telomere length and subtelomeric methylation status in patients with Parkinson's disease2012

    • Author(s)
      Maeda T, Jing-Zhi Guan, Koyanagi M, Makino N
    • Journal Title

      Ageing Res

      Volume: 4 Pages: 61-66

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Aging-associated alteration of telomere length and subtelomeric status in female patients with Parkinson's disease2012

    • Author(s)
      Toyoki Maeda, Jing Zhi Guan, Masamichi Koyanagi, Yoshihiro Higuchi, Naoki Makino
    • Journal Title

      Neurogenetics

      Volume: 26 Pages: 245-251

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Antioxidant Therapy Attenuates Myocardial Telomerase Activity Reduction in Superoxide Dismutase-Deficient Mice2011

    • Author(s)
      Makino N, Maeda T, Oyama JI, Sasaki M, Higuchi Y, Mimori K, Shimizu T
    • Journal Title

      J Mol Cell Cardiol

      Volume: 50 Pages: 670-677

    • NAID

      120004951631

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] The effect of vitamin E administration on the elevated oxygen stress and the telomeric and subtelomeric status in Alzheimer's disease2011

    • Author(s)
      Jing-Zhi Guan, Wei-Ping Guan, Toyoki Maeda, Naoki Makino
    • Journal Title

      Gerontology

      Volume: 58 Pages: 62-69

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular events.2011

    • Author(s)
      T Maeda, JI Oyama, M Koyanagi, Y Higuchi, M Sasaki, K Mimori, T Arima, N Makino
    • Journal Title

      Aging Male 14

      Pages: 21-26

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] The correlation between the clinical laboratory data and the telomere length in peripheral blood leukocytes of Japanese female patients with hypertension.2011

    • Author(s)
      T Maeda, JI Oyama, M Sasaki, T Arima, N Makino
    • Journal Title

      J Nutr Health Aging 15

      Pages: 240-244

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] 種々の臨床検査値と末梢血白血球テロメア関連パラメータとの連関の解析.2011

    • Author(s)
      前田豊樹,小柳雅孔,尾山純一,樋口義洋,牧野直樹
    • Journal Title

      適応医学

      Volume: 14 Pages: 50-59

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] 種々の臨床検査値と末梢血白血球テロメア関連パラメータとの連関の解析2011

    • Author(s)
      前田豊樹, 小柳雅孔, 尾山純一, 樋口義洋, 牧野直樹
    • Journal Title

      適応医学 14

      Pages: 50-59

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] The correlation between the clinical laboratory data and the telomere length in peripheral blood leukocytes of Japanese female patients with hypertension.2011

    • Author(s)
      T Maeda, J-I Oyama, M Sasaki, T Arima, N Makino.
    • Journal Title

      J Nutr Health Aging

      Volume: 15 Pages: 240-245

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] The subtelomere of short telomeres is hypermethylated in Alzheimer's disease2011

    • Author(s)
      Jing-Zhi Guan, Toyoki Maeda, Naoki Makino
    • Journal Title

      Aging and Disease

      Volume: 3 Pages: 164-170

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] Telomerase inhibition promotes an initial step of cell differentiation of primate embryonic stem cell2011

    • Author(s)
      Maeda T, Kurita R, Yokoo T, Tani K, Makino N
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 407 Pages: 491-494

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] 種々の臨床検査値と末梢血白血球テロメア関連パラメータとの連関の解析2011

    • Author(s)
      前田豊樹,小柳雅孔,尾山純一,樋口義洋,牧野直樹
    • Journal Title

      適応医学

      Volume: 14 Pages: 50-59

    • Data Source
      KAKENHI-PROJECT-23590885
  • [Journal Article] 種々の臨床検査値と末梢血白血球テロメア関連パラメータとの連関の解析2010

    • Author(s)
      前田豊樹, 小柳雅孔, 尾山純一, 樋口義洋, 牧野直樹
    • Journal Title

      適応医学

      Volume: 14 Pages: 50-59

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Green Tea Catechins Improve Human Forearm Endothelial Dysfunction and Have Antiatherosclerotic Effects in Smokers.2010

    • Author(s)
      JI.Oyama, T.Maeda, K.Kouzuma, R.Ochiai, I.Tokimitsu, Y.Higuchi, M.Sugano, N.Makino
    • Journal Title

      Circ J. 74

      Pages: 578-588

    • NAID

      10025943880

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] The physical ability of Japanese female elderly with cerebrovascular disease correlates to the telomere length and subtelomeric methylation status in their peripheral blood leukocytes.2010

    • Author(s)
      T.Maeda, JI.Oyama, Y.Higuchi, Y.Nishiyama, Y.Kudo, T Yamori, T.Nakazono, T.Arima, K.Mimori, N.Makino
    • Journal Title

      Gerontology 57

      Pages: 137-143

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Green tea catechins improve human forearm vascular function and have potent anti-inflammatory and anti-apoptotic effects in smokers.2010

    • Author(s)
      J-I Oyama, T Maeda, M Sasaki, K Kozuma, R Ochiai, I Tokimitsu, S Taguchi, Y Higuchi, N Makino N.
    • Journal Title

      Intern Med.

      Volume: 49 Pages: 2553-2559

    • NAID

      130000413399

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] The physical ability of elderly female Japanese patients with cerebrovascular disease correlates with the telomere length in their peripheral blood leukocytes.2010

    • Author(s)
      T Maeda, J-I Oyama, M Sasaki, Y Nishiyama, Y Kudo, T Yamori, T Nakazono, T Arima, N Makino.
    • Journal Title

      Aging Clin Exp Res

      Volume: 23 Pages: 1-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] The physical ability of Japanese female elderly with cerebrovascular disease correlates to the telomere length and subtelomeric methylation status in their peripheral blood leukocytes.2010

    • Author(s)
      T Maeda, J-I Oyama, Y Higuchi, Y Nishiyama, Y Kudo, T Yamori, T.Nakazono, T.Arima, K Mimori, N.Makino.
    • Journal Title

      Gerontology

      Volume: 57 Pages: 137-143

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] 女性高血圧患者における血液検査値と末梢血テロメア長の相関について2010

    • Author(s)
      前田豊樹、牧野直樹
    • Journal Title

      日本老年医学会雑誌 47

      Pages: 573-577

    • NAID

      10028123522

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] 高血圧患者におけるアムロジピン錠「EMEC」の臨床的検討2010

    • Author(s)
      前田豊樹、牧野直樹
    • Journal Title

      Progress in Medicine

      Volume: 30 Pages: 3143-3152

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo.2010

    • Author(s)
      JI.Oyama, S.Satoh, N.Suematsu, T.Kadokami, T.Maeda, M.Sugano, N.Makino
    • Journal Title

      Heart Vessels 25

      Pages: 379-385

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] The correlation between the telomeric parameters and the clinical laboratory data in the patients with brain infarct and metabolic disorders.2010

    • Author(s)
      T.Maeda, JI.Oyama, Y.Higuchi, T.Arima, K.Mimori, N.Makino
    • Journal Title

      J Nutr Health Aging 14

      Pages: 793-797

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular events.2010

    • Author(s)
      T Maeda, J-I Oyama, M Koyanagi, Y Higuchi, M Sasaki, K Mimori, T Arima, N Makino
    • Journal Title

      Aging Male

      Volume: 14 Pages: 21-26

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] 高血圧患者におけるアムロジピン錠「EMEC」の臨床的検討2010

    • Author(s)
      前田豊樹, 牧野直樹
    • Journal Title

      Prog Med. 30

      Pages: 3143-3152

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Green tea catechins improve human forearm vascular function and have potent anti-inflammatory and anti-apoptotic effects in smokers.2010

    • Author(s)
      JI Oyama, T Maeda, M Sasaki, K Kozuma, R Ochiai, I Tokimitsu, S Taguchi, Y Higuchi, N Makino
    • Journal Title

      Intern Med. 49

      Pages: 2553-2559

    • NAID

      130000413399

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Antioxidant Therapy Attenuates Myocardial Telomerase Activity Reduction in Superoxide Dismutase-Deficient Mice.2010

    • Author(s)
      N Makino, T Maeda T, JI Oyama, M Sasaki, Y Higuchi, K Mimori, T Shimizu
    • Journal Title

      J Mol Cell Cardiol. 50

      Pages: 670-677

    • NAID

      120004951631

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] 女性高血圧患者における血液検査値と末梢血テロメア長の相関について2010

    • Author(s)
      前田豊樹、牧野直樹
    • Journal Title

      日本老年医学会雑誌

      Volume: 472 Pages: 573-577

    • NAID

      10028123522

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] The correlation between the telomeric parameters and the clinical laboratory data in the patients with brain infarct and metabolic disorders.2010

    • Author(s)
      T Maeda, J-I Oyama, Y Higuchi, T Arima, K Mimori, N Makino.
    • Journal Title

      J Nutr Health Aging

      Volume: 14 Pages: 793-797

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Telomere biology in cardiovascular disease - role of insulin sensitivity in diabetic hearts.2010

    • Author(s)
      N Makino, M Sasaki, T Maeda, K Mimori
    • Journal Title

      Exp Clin Cardiol. 15

      Pages: 128-133

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo.2010

    • Author(s)
      J-I Oyama, S Satoh, N Suematsu, T Kadokami, T Maeda, M Sugano, N Makino.
    • Journal Title

      Heart Vessels

      Volume: 25 Pages: 379-385

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Green Tea Catechins Improve Human Forearm Endothelial Dysfunction and Have Antiatherosclerotic Effects in Smokers.2010

    • Author(s)
      J-I Oyama, T.Maeda, K.Kouzuma, R.Ochiai, I.Tokimitsu, Y Higuchi, M Sugano, N Makino
    • Journal Title

      Circ J.

      Volume: 74 Pages: 578-588

    • NAID

      10025943880

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Antioxidant Therapy Attenuates Myocardial Telomerase Activity Reduction in Superoxide Dismutase-Deficient Mice.2010

    • Author(s)
      N Makino, T Maeda, J-I Oyama, M Sasaki, Y Higuchi, K Mimori, T Shimizu.
    • Journal Title

      J Mol Cell Cardiol.

      Volume: 50 Pages: 670-677

    • NAID

      120004951631

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Telomere biology in cardiovascular disease-role of insulin sensitivity in diabetic hearts.2010

    • Author(s)
      N Makino, M Sasaki, T Maeda, K Mimori.
    • Journal Title

      Exp Clin Cardiol.

      Volume: 15 Pages: 128-133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Improving insulin sensitivity via activation of PPAR-gamma increases telomerase activity in the heart of OLETF rats2009

    • Author(s)
      牧野直樹, 前田豊樹, 尾山純一, 樋口義洋, 三森功士
    • Journal Title

      Am J Physiol Heart Circ Physiol 297

      Pages: 2188-2195

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Aging-associated alteration of subtelomeric methylation in Parkinson's disease.2009

    • Author(s)
      T Maeda, JZ Guan, JI Oyama, Y Higuchi, N Makino
    • Journal Title

      J Gerontol A Biol Sci and Med Sci 64

      Pages: 949-955

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Improving insulin sensitivity via activation of PPAR-gamma increases telomerase activity in the heart of OLETF rats.2009

    • Author(s)
      N.Makino, T.Maeda, JI Oyama, Y.Higuchi, K Mimori
    • Journal Title

      Am J Physiol Heart Circ Physiol. 297

      Pages: 2188-2195

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] 老化促進に作用する環境因子2009

    • Author(s)
      牧野直樹、前田豊樹、尾山純一、樋口義洋
    • Journal Title

      日本臨床 67

      Pages: 1332-1336

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Age-related changes in subtelomeric methylation in the normal Japanese population2009

    • Author(s)
      前田豊樹, 管静芝, 尾山純一, 樋口義洋, 牧野直樹
    • Journal Title

      J Gerontol A Biol Sci Med Sci. 64

      Pages: 426-434

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Age-related changes in subtelomeric methylation in the normal Japanese population.2009

    • Author(s)
      Maeda T, Guan JZ, Oyama J, Higuchi Y, Makino N.
    • Journal Title

      The Journals of Gerontology. Seies A, Biological Sciences and Medical Sciences. 64

      Pages: 426-434

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Aging-associated alteration of subtelomeric methylation in Parkinson's disease2009

    • Author(s)
      前田豊樹, 管静芝, 尾山純一, 樋口義洋, 牧野直樹
    • Journal Title

      J Gerontol A Biol Sci Med Sci. 64

      Pages: 949-955

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] TNF-alpha employs a protein-tyrosine phosphatase to inhibit activation of hepatocyte growth factor receptor and hepatocyte growth factorinduced endothelial cell proliferation.2009

    • Author(s)
      Sugano M, Iwasaki Y, Abe M, Maeda T, Tsuchida K, Makino N.
    • Journal Title

      Molecular and Cellular Biochemistry 322

      Pages: 113-117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Age-related changes in subtelomeric methylation in the normal Japanese population.2009

    • Author(s)
      T Maeda, JZ Guan, JI Oyama, Y Higuchi, N Makino
    • Journal Title

      J Gerontol A Biol Sci and Med Sci 64

      Pages: 426-434

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Diagonal earlobe crease are associated with shorter telomere in male Japanese patients with metabolic syndrome.2009

    • Author(s)
      Higuchi Y, Maeda T, Guan JZ, Oyama J, Sugano M, Makino N
    • Journal Title

      Circulation Journal 73

      Pages: 274-279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Aging-related alterations of subtelomeric methylation in sarcoidosis patients2009

    • Author(s)
      前田豊樹, 管静芝, 尾山純一, 樋口義洋, 牧野直樹
    • Journal Title

      J Gerontol A Biol Sci Med Sci. 64

      Pages: 752-760

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] 老化促進に作用する環境因子2009

    • Author(s)
      牧野直樹, 前田豊樹, 尾山純一, 樋口義洋
    • Journal Title

      日本臨床 67

      Pages: 1332-1336

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Aging-associated alteration of subtelomeric methylation in Parkinson's disease2009

    • Author(s)
      Maeda T, Guan JZ, Oyama J, Higuchi Y, Makino N.
    • Journal Title

      The Journals of Gerontology. Seies A, Biological Sciences and Medical Sciences. (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Diagonal Earlobe Creases Are Associated with a Shorter Telomere Length in Male Japanese Patients with Metabolic Syndrome2009

    • Author(s)
      Y Higuchi, T Maeda, JI Oyama, N Makino
    • Journal Title

      - A Pilot Study- Circ J 73

      Pages: 274-279

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Aging-related alterations of subtelomeric methylation in sarcoidosis patients.2009

    • Author(s)
      T Maeda, JZ Guan, JI Oyama, Y Higuchi, N Makino
    • Journal Title

      J Gerontol A Biol Sci and Med Sci 64

      Pages: 752-760

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] TNF-alpha employs a protein-tyrosine phosphatase to inhibit activation of hepatocyte growth factor receptor and hepatocyte growth factor-induced endothelial cell2009

    • Author(s)
      M Sugano, Y Iwasaki, M Abe, T Maeda, K Tsuchida, N Makino
    • Journal Title

      proliferation. Mol Cell Biochem. 322

      Pages: 113-117

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Aging-related alterations of subtelomeric methylation in sarcoidosis patients2009

    • Author(s)
      Maeda T, Guan JZ, Oyama J, Higuchi Y, Makino N.
    • Journal Title

      The Journals of Gerontology. Seies A, Biological Sciences and Medical Sciences. (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] An analysis of the telomere length distribution in Parkinson's disease patients.2008

    • Author(s)
      JZ Guan, T Maeda, M Sugano, J Oyama, Y Higuchi, N Makino
    • Journal Title

      J Gerontol A Biol Sci and Med Sci 63

      Pages: 467-473

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] A percentage analysis of the telomere length in Parkinson's disease patients.2008

    • Author(s)
      Guan JZ, Maeda T, Sugano M, Oyama J, Higuchi Y, Suzuki TMakino N.
    • Journal Title

      The Journals of Gerontology. Seies A, Biological Sciences and Medical Sciences. 63

      Pages: 467-473

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] SiRNA targeting SHP-1 accelerates angiogenesis in a rat model of hindlimb ischemia.) : 33-9.2007

    • Author(s)
      Sugano M, Tsuchida K. Maeda T, Makino N
    • Journal Title

      Atherosclerosis. 191

      Pages: 33-39

    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] Transient receptor potential (TRP) protein 7 acts as a G protein-activated Ca2+ channel mediating angiotensin II-induced myocardial apoptosis.2007

    • Author(s)
      Satoh S, Tanaka H, Ueda Y, Oyama J, Sugano M, Sumimoto H, Mori Y, Makino N
    • Journal Title

      Mol Cell Biochem. 294

      Pages: 205-215

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] SiRNA targeting SHP-1 accelerates angiogenesis in a rat model of hindlimb ischemia.) : 33-9.2007

    • Author(s)
      Sugano M, Tsuchida K, Maeda T, Makino N
    • Journal Title

      Atherosclerosis. 191

      Pages: 33-39

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] Transient receptor potential (TRP) protein 7 acts as a G protein-activated Ca2+ channel mediating angiotensin II- induced myocardial apoptosis.2007

    • Author(s)
      Satoh S, Tanaka H, Ueda Y, Oyama J, Sugano M, Sumimoto H, Mori Y, Makino N
    • Journal Title

      Mol Cell Biochem. 294

      Pages: 205-215

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] Transient receptor potential (TRP) protein 7 acts as a G protein-activated Ca2+channel mediating angiotensin II-induced myocardial apoptosis.2007

    • Author(s)
      Satoh S, Tanaka H, Ueda Y, Oyama J, Sugano M, Sumimoto H, Mori Y, Makino N
    • Journal Title

      Mol Cell Biochem. 294

      Pages: 205-215

    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] SiRNA targeting SHP-l accelerates angiogenesis in a rat model of hindlimb ischemia.2007

    • Author(s)
      Sugano M, Tsuchida K, Maeda T, Makino N
    • Journal Title

      Atherosclerosis. 191

      Pages: 33-39

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia.2006

    • Author(s)
      Makino N, Sugano M, Satoh S, Oyama J, Maeda T.
    • Journal Title

      Cell Biochem Biophys. 44

      Pages: 65-71

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] Somatic DNA recombination in a mouse genomic region, BC-1, in brain and non-brain tissue.2006

    • Author(s)
      Maeda T, Mizuno R, Sugano M, Satoh S, Oyama J, Sakoda S, Suzuki T, Makino N
    • Journal Title

      Can J Physiol Phafmacol. 84

      Pages: 443-449

    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia.2006

    • Author(s)
      Makino N, Sugano M, Satoh S, Oyama J, Maeda T
    • Journal Title

      Cell Biochem Biophys. 44

      Pages: 65-71

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] Somatic DNA recombination in a mouse genomic region, BC-1,in brain and non-brain tissue.2006

    • Author(s)
      Maeda T, Mizuno R, Sugano M, Satoh S, Oyama J, Sakoda S, Suzuki T, Makino N
    • Journal Title

      Can J Physiol Pharmacol. 84

      Pages: 443-449

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia.2006

    • Author(s)
      Makino N, Sugano M, Satoh S, Oyama J, Maeda T.
    • Journal Title

      Cell Biochem Biophys 44(1)

      Pages: 65-71

    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] Somatic DNA recombination in the brain.2006

    • Author(s)
      Maeda T, Sakoda S, Suzuki T, Makino N.
    • Journal Title

      Can J Physiol Pharmacol 84

      Pages: 319-324

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] Somatic DNA recombination in a mouse genomic region, BC-l, in brain and nonbrain tissue.2006

    • Author(s)
      Maeda T, Mizuno R, Sugano M, Satoh S, Oyama J, Sakoda S, Suzuki T, Makino N
    • Journal Title

      Can J Physiol Pharmacol. 84

      Pages: 443-449

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] Somatic DNA recombination in the brain.2006

    • Author(s)
      Maeda T, Sakoda S, Suzuki T, Makino N
    • Journal Title

      Can J Physiol Pharmacol 84

      Pages: 319-324

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuietic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia.2006

    • Author(s)
      Makino N, Sugano M, Satoh S, Oyama J, Maeda T.
    • Journal Title

      Cell Biochem Biophys. 44

      Pages: 65-71

    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] High serum TNF-alpha level in Type 2 diabetic patients with microangiopathy is associated with eNOS down-regulation and apoptosis in endothelial cells2005

    • Author(s)
      Makino N, Maeda T, Sugano M, Satoh S, Watanabe R, Abe N
    • Journal Title

      J Diabetes Complications. 19(6)

      Pages: 347-355

    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] RNA interference targeting SHP-1 attenuates myocardial infarction in rats.2005

    • Author(s)
      Sugano M, Tsuchida K, Hata T, Makino N.
    • Journal Title

      FASEB J. 19(14)

      Pages: 2054-2056

    • Data Source
      KAKENHI-PROJECT-17590746
  • [Journal Article] The effect of vitamin E administration on the elevated oxygen stress and the telomeric and subtelomeric status in Alzheimer's disease.

    • Author(s)
      JZ Guan, WP Guan, T Maeda, N Makino
    • Journal Title

      Gerontology. in press.

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] The effect of vitamin E administration on the elevated oxygen stress and the telomeric and subtelomeric status in Alzheimer's disease.

    • Author(s)
      JZ Guan, WP Guan, T Maeda, N Makino
    • Journal Title

      Gerontology

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Telomerase inhibition promotes an initial step of cell differentiation of primate embryonic stem cell

    • Author(s)
      T Maeda, R Kurita, T Yokoo, K Tani, N Makino.
    • Journal Title

      Biochem.Biophys.Res.Commun

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] The physical ability of elderly female Japanese patients with cerebrovascular disease correlates with the telomere length in their peripheral blood leukocytes.

    • Author(s)
      T.Maeda, JI Oyama, M.Sasaki, Y.Nishiyama, Y.Kudo, T.Yamori, T.Nakazono, T.Arima, N.Makino
    • Journal Title

      Aging Clin Exp Res. in press.

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Journal Article] Telomerase inhibition promotes an initial step of cell differentiation of primate embryonic stem cell.

    • Author(s)
      T Maeda, R Kurita, T Yokoo, K Tani, N Makino
    • Journal Title

      Biochem.Biophys.Res.Commun. in press.

    • Data Source
      KAKENHI-PROJECT-20590703
  • [Presentation] Thrombomodulin Alpha Improved the Cardiac Function but not Hypertrophy in a Transgenic Mouse Model of Inflammatory Cardiomyopathy2013

    • Author(s)
      Higuchi Y, Koyanagi M, Kubota T, Feldman AM, and Makino N.
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-24591098
  • [Presentation] 心エコー検査による心機能評価と白血球テロメア長の相関について2013

    • Author(s)
      前田豊樹、牧野直樹
    • Organizer
      第23回日本老年医学会九州地方会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-09
    • Data Source
      KAKENHI-PROJECT-23590885
  • [Presentation] アルツハイマー病女性患者における末梢白血球テロメア長の変化について2012

    • Author(s)
      前田豊樹、牧野直樹
    • Organizer
      第54回日本老年医学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23590885
  • [Presentation] 鉱泥浴治療効果の客観的指標の探索2012

    • Author(s)
      前田豊樹、工藤義弘、西山保弘、牧野直樹
    • Organizer
      第77回に本温泉気候物理学会
    • Place of Presentation
      仙北
    • Data Source
      KAKENHI-PROJECT-23590885
  • [Presentation] パーキンソン病女性患者における末梢白血球テロメア長の変化について2012

    • Author(s)
      前田豊樹、牧野直樹
    • Organizer
      第22回日本老年医学会九州地方会
    • Place of Presentation
      佐賀
    • Year and Date
      2012-03-03
    • Data Source
      KAKENHI-PROJECT-23590885
  • [Presentation] 鉱泥浴治療効果の客観的指標の探索2012

    • Author(s)
      前田豊樹、工藤義弘、西山保弘、牧野直樹
    • Organizer
      第77回日本温泉気候物理学会
    • Place of Presentation
      仙北
    • Data Source
      KAKENHI-PROJECT-23590885
  • [Presentation] 外来男性生活習慣病患者における臨床検査値と末梢白血球テロメア長の相関の検討2011

    • Author(s)
      前田豊樹、牧野直樹
    • Organizer
      第21回日本老年医学会九州地方会
    • Place of Presentation
      福岡
    • Year and Date
      2011-03-05
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Presentation] 外来男性生活習慣病患者における各種臨床検査値と末梢血白血球テロメア長関連パラメータについて2011

    • Author(s)
      前田豊樹、牧野直樹
    • Organizer
      第53回日本老年医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-16
    • Data Source
      KAKENHI-PROJECT-23590885
  • [Presentation] 高血圧治療中女性患者における各種臨床検査値と末梢血白血球テロメア長の相関の検討2010

    • Author(s)
      前田豊樹, 牧野直樹
    • Organizer
      第20回日本老年医学会九州地方会
    • Place of Presentation
      熊本
    • Year and Date
      2010-03-13
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Presentation] 療養病床における女性脳卒中入院患者の身体機能と末梢血白血球テロメア長関連パラメータの相関について2010

    • Author(s)
      前田豊樹、牧野直樹
    • Organizer
      第52回日本老年医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2010-06-25
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Presentation] 女性高血圧患者における各種臨床検査値と末梢血白血球テロメア長の相関の検討2010

    • Author(s)
      前田豊樹、牧野直樹
    • Organizer
      第19回日本老年医学会九州地方会
    • Place of Presentation
      熊本
    • Year and Date
      2010-03-13
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Presentation] 高血圧治療中女性患者における各臨床検査値と末梢血白血球テロメア長の相関の検討2010

    • Author(s)
      前田豊樹、尾山純一、樋口義洋、牧野直樹
    • Organizer
      第107回日本内科学会総会・講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-10
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Presentation] 療養病床高齢入院患者における種々の臨床検査値と末梢血白血球テロメア長の相関について2009

    • Author(s)
      前田豊樹, 牧野直樹
    • Organizer
      第51回日本老年医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-20
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Presentation] 療養病床入院患者末梢血白血球テロメア長の解析2009

    • Author(s)
      前田豊樹, 牧野直樹
    • Organizer
      第18回日本老年医学会九州地方会
    • Place of Presentation
      宮崎(宮崎大学医学部)
    • Year and Date
      2009-03-06
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Presentation] Telomeric and subtelomeric structural change with aging in chronically ill patients2009

    • Author(s)
      前田豊樹, 尾山純一, 樋口義洋, 牧野直樹
    • Organizer
      XIXth IAGG World Congress of gerontology and geriatrics
    • Place of Presentation
      Paris
    • Year and Date
      2009-07-06
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Presentation] ゲノムDNAの加齢性変化と疾病2008

    • Author(s)
      前田豊樹、牧野直樹
    • Organizer
      第12回日本適応医学会シンポジゥム
    • Place of Presentation
      別府
    • Year and Date
      2008-06-06
    • Data Source
      KAKENHI-PROJECT-20590703
  • [Presentation] サブテロメア領域のメチル化の加齢性変化について2008

    • Author(s)
      前田豊樹、牧野直樹
    • Organizer
      第18回日本老年医学会九州地方会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-01
    • Data Source
      KAKENHI-PROJECT-20590703
  • 1.  YANO Kenichi (60230281)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 2.  HATA Tomoji (90198739)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  MAEDA Toyoki (30264112)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 113 results
  • 4.  OYAMA Junichi (30359939)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 49 results
  • 5.  KOYANAGI Masamichi (00325474)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 16 results
  • 6.  YANAGA Takashi (80038702)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  HATAKENAKA Masamitu (40253413)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  HIGUCHI Yoshihiro (40404032)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 34 results
  • 9.  SUGANO Masahiro (20206395)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 10.  NIIDOME Takuro (20264210)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  MATSUI Hirosuke (10284572)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  SATOH Shinji (60274445)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  YOSHIMITU Kengo (20274467)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  ADACHI Toshisada (10335979)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  YUHEI ICHIMARU (70038909)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  YOSHIDA Satoshi (50158440)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  安藤 洋志 (80301349)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  増田 康治 (10037377)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  大塚 誠 (60203840)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  門上 俊明 (40335980)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  上野 照紀 (10117070)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  TSUCHIDA Keiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  MATSUTOMO Kazuhiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  HIRAYAMA Hiroyoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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