HANEDA Masakazu 羽田勝計

Researcher Number	60164894
Other IDs
Affiliation (based on the past Project Information) *help	2004: ASAHIKAWA MEDICAL COLLEGE, PROFESSOR, 医学部, 教授 2004: 旭川医科大学, 第二内科, 教授 1998 – 2003: 滋賀医科大学, 医学部, 講師 1999: SHIGA UNIVERSITY OF MEDICAL SCIENCE, ASSISTANT PROFESSOR, 医学部, 助手 1992 – 1997: 滋賀医科大学, 医学部, 助手 1988 – 1989: 滋賀医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator 内分泌・代謝学 / Metabolomics Except Principal Investigator Biological Sciences / Metabolomics / Metabolomics / Kidney internal medicine / 内分泌・代謝学
Keywords	Principal Investigator 糖尿病性腎症 / メサンギウム細胞 / Mesangial cells / Protein kinase C / Diabetic nephropathy / messenger RNA / NADPH oxidase / 糖尿病 / PKC-β / cAMP … More / cGMP / TGF-β / mRNA differential display / 腎糸球体 / Glomerular hyperfiltration / intrarenal hemodynamic alterations / diabetes mellitus / kidney / glomerular mesangial cells / angiotensin converting enzyme / angiotensinogen / renin / レニン・アンジオテンシノーゲンmRNA / 腎糸球体メサンギウム細胞 / 糸球体メカンギウム細胞 / 腎内血行動態異常 / 腎臓 / 糸球体メサンギウム細胞 / アンジオテンシン変換酵素 / アンジオテンシノ-ゲン / レニン / mesangial cells / diabetic nephropathy / oxidative stress / heme oxygenase-1 / PKC / 糸球体 / HO-1 / NADPHオキシダーゼ / 酸化ストレス / extracellular matrix protein / extracellular signal-regulated kinase (ERK) / Stretch stress / ブドウ糖過剰 / MAP kinase / 細胞外基質 / fibronectin / extracellular signal-regulated kinase(ERK) / 高糖濃度 / 周期的伸展刺激 / 糸球体高血圧 / gene expression / Advanced glycation end products(AGE) / 遺伝子発現 / 終末糖化産物(AGE) / Cytosolic phospholipase A2 / Mitogen-activated protein kinase (MAPK) cascade / Diabetic glomeruli / Diabetic nephropathy. / 血管収縮物質 / 成長因子 / MAPキナーゼキナーゼ / MAPキナーゼ / 糸球体過剰口過 / MAP kinase cascade / 糸球体過剰ロ過 / cPLA_2 / MAP Kinase cascade / Protein Kinase C / Inositol 1, 4, 5-trisphosphate / Atrial natriuretic peptide / Angiotensin II / グアニル酸シクラーゼ / 心房性ナトリウム料尿ペプチド / 心房性ナトリウム利尿ペプチド / IP_3 / C-キナーゼ / 心戻性ナトリウム利尿ペプチド / アンジオテンシンII / 糸球体濾過値 … More Except Principal Investigator 糖尿病性腎症 / TGF-β / 糖尿病合併症 / Ac-SDKP / PKC / 遺伝子多型 / 糖尿病 / Smad / メサンギウム細胞 / 白血球DNA / 家系図 / diabetic nephropathy / db / AP-1 / fibronectin / DIABETIC NEPHROPATHY / smad / db mouse / mesangial cell / mesangial expansion / albuminuria / 血清クレアチニン / ANTIOXIDANTS / OXIDATIVE STRESS / DIACYLGILYCEROL KINASE / DGK / 抗酸化薬 / 酸化ストレス / Diacylglycerol Kinase / pioglitazone / mesangial cells / MAPKs / 細胞外基質 / ピオグリタゾン / GLOMERULOSCLEROSIS / PKC INHIBITOR / URINARY ALBUMIN / メサンギウム領域 / PKC阻害剤 / 糸球体硬化 / PKCβ阻害剤 / 尿中アルブミン / Gene expression / Cyclic stretch / Glomerular hypertension / Mesangial cell / Diabetic nephoropathy / 遺伝子発現 / 周期的伸展刺激 / 糸球体高血圧 / 家計図 / PKC beta / 候補遺伝子 Less

糖尿病合併症・糖尿病薬剤感受性遺伝子の同定と新たな治療戦略への展開
- Principal Investigator
  
  柏木厚典
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
糖尿病合併症家系図の構築と糖尿病合併症候補遺伝子の検索
- Principal Investigator
  
  柏木厚典
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
Effect of N-acetyl seryl-aspartyl-lysyl-proline on renal insufficiency and mesangial matrix expansion in diabetic db/db mice
- Principal Investigator
  
  KOYA Daisuke
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
糖尿病合併症家系図の構築と糖尿病合併症候補遺伝子の検索
- Principal Investigator
  
  柏木厚典
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
糖尿病合併症家系図の構築と糖尿病合併症候補遺伝子に検索
- Principal Investigator
  
  柏木厚典
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
Mechanism of glomerular abnormality by oxidative stress in diabetic nephropathyPrincipal Investigator
- Principal Investigator
  
  HANEDA Masakazu
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Shiga University of Medical Science
糖尿病合併症家系図の構築と糖尿病合併症候補遺伝子の探索
- Principal Investigator
  
  KIKKAWA Ryuichi
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Shiga University of Medical Science
Development of the treatment of diabetic nephropathy by targeting the TGF-β signaling
- Principal Investigator
  
  KIKKAWA Ryuichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Shiga University of Medical Science
Molecular Mechanism in the development of diabetic nephropathy-the role of diacylglycerol kinase in regulating protein kinase C activity-
- Principal Investigator
  
  KOYA Daisuke
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
ROLE OF DIABETES-INDUCED GLOMERULAR PKC-MAPK ACTIVATION ON DIABETIC GLOMERULOSCLEROSIS
- Principal Investigator
  
  KOYA Daisuke
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
MOLECULAR MECHANISM OF MESANGIAL CELL DYSFUNCTION DUE TO HYPERGLYCEMIA AND GLOMERULAR HYPERTENSIONPrincipal Investigator
- Principal Investigator
  
  HANEDA Masakazu
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
The molecular mechanism of increase of TGF-β expression in diabetic glomeruli
- Principal Investigator
  
  KIKKAWA Ryuichi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Shiga University of Medical Science
IDENTIFICATION OF GENES REGULATED BY ADVANCED GLYCATION END PRODUCTS IN CULTURED GLOMERULAR MESANGIAL CELLSPrincipal Investigator
- Principal Investigator
  
  HANEDA Masakazu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
ABNORMAL SIGNAL TRUNSDUCTION IN MESANGIAL CELLS IN DIABETESPrincipal Investigator
- Principal Investigator
  
  HANEDA Masakazu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
MOLECULAR MECHANISM OF MESANGIAL DYSFUNCTION IN DIABETESPrincipal Investigator
- Principal Investigator
  
  HANEDA Masakazu
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
Regulation of renin and angiotensinogen gene expression in glomerular mesangial cells.Principal Investigator
- Principal Investigator
  
  HANEDA Masakazu
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Shiga University of Medical Science

All 2005 2003

All Journal Article

[Journal Article] N-acetyl seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice2005
- Author(s)
  Shibuya K, Kanasaki K, Isono M, Sato H, Omata M, Sugimoto T, Araki S, Isshiki K, Kashiwagi A, Haneda M, Koya D.
- Journal Title
  
  Diabetes 54
  
  Pages: 200-208
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590936
[Journal Article] N-acetyl-seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db/db mice.2005
- Author(s)
  Shibuya K, Kanasaki K, Isono M, Sato H, Omata M, Sugimoto T, Araki S, Isshiki K, Kashiwagi A, Haneda M, Koya D.
- Journal Title
  
  Diabetes 54
  
  Pages: 838-845
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590936
[Journal Article] N-Acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-beta-mediated plasminogen activator inhibitor-1 expression via inhibition of Smad pathway in human mesangial cells.2003
- Author(s)
  Kanasaki K, Koya D, Sugimoto T, Isono M, Kashiwagi A, Haneda M.
- Journal Title
  
  J Am Soc Nephrol. 14
  
  Pages: 863-872
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590936
[Journal Article] N-Acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-beta-mediated plasminogen activator inhibitor-1,expression via inhibition of Smad pathway in human mesangial cells.2003
- Author(s)
  Kanasaki K, Koya D, Sugimoto T, Isono M, Kashiwagi A, Haneda M.
- Journal Title
  
  J Am Soc Nephrol 14
  
  Pages: 863-872
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590936

1. KOYA Daisuke (70242980)

# of Collaborated Projects: 12 results

# of Collaborated Products: 4 results
2. 柏木厚典 (20127210)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. 荒木信一 (80378455)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. KIKKAWA Ryuichi (50093406)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. MAEDA Shiro (50314159)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 前川聡 (00209363)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. NISHIO Yoshihiko (40281084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HANEDA Masakazu 羽田 勝計

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Mechanism of glomerular abnormality by oxidative stress in diabetic nephropathyPrincipal Investigator

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MOLECULAR MECHANISM OF MESANGIAL CELL DYSFUNCTION DUE TO HYPERGLYCEMIA AND GLOMERULAR HYPERTENSIONPrincipal Investigator

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IDENTIFICATION OF GENES REGULATED BY ADVANCED GLYCATION END PRODUCTS IN CULTURED GLOMERULAR MESANGIAL CELLSPrincipal Investigator

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ABNORMAL SIGNAL TRUNSDUCTION IN MESANGIAL CELLS IN DIABETESPrincipal Investigator

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MOLECULAR MECHANISM OF MESANGIAL DYSFUNCTION IN DIABETESPrincipal Investigator

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HANEDA Masakazu 羽田勝計