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KOGA Yasuhiro  古賀 泰裕

ORCIDConnect your ORCID iD *help
Researcher Number 60170221
Other IDs
Affiliation (based on the past Project Information) *help 2019: 東海大学, 医学部, 教授
1995 – 2017: 東海大学, 医学部, 教授
1993 – 1994: 東海大, 医, 教授
1990 – 1992: 九州大学, 生体防御医学研究所, 助教授
1989: 九州大学, 生体防御医学研究所, 助手
Review Section/Research Field
Principal Investigator
Virology / Immunology
Except Principal Investigator
General internal medicine (including Psychosomatic medicine) / General internal medicine(including psychosomatic medicine) / Environmental physiology (including Physical medicine and Nutritional physiology) / Environmental physiology(including physical medicine and nutritional physiology) / 膠原病・アレルギー・感染症内科学 / Virology
Keywords
Principal Investigator
HIV / gp160 / カルモジュリン / アポトーシス / CD4 / lung / latent infection / NO / iNOS / MCMV-DNA … More / reactivation / graft-versus-host reaction / cytomegalovirus / Ca^<2+> / TCR / Lck / チロシンキナーゼ / apoptosis / calmodulin / ERストレス / カルシウムイオン / ミトコンドリア / カルモジュリンキナーゼ / 再活性化 / 潜伏感染 / サイトメガロウイルス / 情報伝達 / チロシンキナ-ゼ / p56lck / LcK / Ca^+ / gp120 / 核膜孔 / env遺伝子 / 細胞傷害 / 核移行タンパク / gP160 / エイズ / CD4抗原 / エンベロ-プ / lck / T細胞 / HTLVーI … More
Except Principal Investigator
腸内細菌 / ストレス / 無菌マウス / 脳腸相関 / Stress / メタボローム / 摂食障害 / 次世代シークエンサー / 神経性やせ症 / バクテリアル・トランスロケーション / 炎症性腸疾患 / セロトニン / バクテリアルトランスロケーション / Neuroinnune / Microbiota / 神経内分泌 / Germ-free mouse / Hypothalamic-pituitary-adrenal axis / Intestinal microbiota / 単一細菌マウス / HPA axis / 視床下部-下垂体-副腎軸 / ストレス反応 / 腸内フローラ / マイクロバイオーム / 神経性食欲不振症 / 不安 / 行動 / 環境生理学 / 腸管 / カテコラミン / 環境 / CD1d / 緑膿菌 / プロバイオティクス / germ-free / NKT細胞 / CDld / bacterial translocation / 腸管免疫 / 消化管免疫 / 感染症学 / 神経科学 / 生理学 / envelope / リンパ腫 / ウイルス中和 / キラーT細胞 / gp160 / HIV / EBウイルス / リンパ節 / 免疫不全 / レトロウイルス / CD4 / 細胞免疫 / リンパ装置 / アポプトーシス / 悪性リンパ腫 / エイズ / サイトメガロウイルス肺炎 / 生体防御機構 / γδ型T細胞 / αβ型T細胞 / インタ-フェロン / NK細胞 / マウスサイトメガロウイルス / マウスボックスウイルス / 癌細胞株 / 3Y1細胞 / E1A遺伝子 / リン脂質 / ジアシルグリセロ-ル / 制癌剤 Less
  • Research Projects

    (23 results)
  • Research Products

    (18 results)
  • Co-Researchers

    (18 People)
  •  Stress causes bacterial translocation: Analysis by high sensitive measurement method

    • Principal Investigator
      Sudo Nobuyuki
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      Kyushu University
  •  Elucidation of pathophysiology of anorexia nervosa and creation of new paradigm: Control of body weight and behavioral characteristics by intestinal bacteria

    • Principal Investigator
      Sudo Nobuyuki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      Kyushu University
  •  How do gut microbes affect host behaviors?

    • Principal Investigator
      Sudo Nobuyuki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental physiology(including physical medicine and nutritional physiology)
    • Research Institution
      Kyushu University
  •  Microbiome and metabolome analysis in patients with anorexia nervosa

    • Principal Investigator
      Kubo Chiharu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      Kyushu University
  •  How does stressor make the hosts susceptible to bacterial infection?

    • Principal Investigator
      SUDO Nobuyuki
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      Kyushu University
  •  Do gut microbiota affect body weight gain in patients with anorexia nervosa?

    • Principal Investigator
      SUDO Nobuyuki
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      Kyushu University
  •  Gut microbiota and Host Stress Response

    • Principal Investigator
      KUBO Chiharu
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      Kyushu University
  •  Mutual interaction of enteric bacteria and immune cells of the gut

    • Principal Investigator
      MATSUMOTO Tetsuya
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Tokyo Medical University
  •  Change in emotional behavior following postnatal microbial colonization

    • Principal Investigator
      KUBO Chiharu
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      Kyushu University
  •  Regulation of hypothalamic-pituitary-adrenal system for stress response by intestinal microbiota

    • Principal Investigator
      KUBO Chiharu
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental physiology (including Physical medicine and Nutritional physiology)
    • Research Institution
      Kyushu University
  •  The role of calmodulin in the determination of cell death by viral infectionPrincipal Investigator

    • Principal Investigator
      KOGA Yasuhiro
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Tokai University
  •  HIV-envによる免疫不全発生の解明Principal Investigator

    • Principal Investigator
      古賀 泰裕
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  The role of nitric oxide in thereactivation of latently infected cytomegalovirusPrincipal Investigator

    • Principal Investigator
      KOGA Yasuhiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Tokai University
  •  HIV-envによる免疫不全発生機序の解明Principal Investigator

    • Principal Investigator
      古賀 泰裕
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  HIV-envによる免疫不全発生機序の解明Principal Investigator

    • Principal Investigator
      古賀 泰裕
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokai University
  •  エイズ制圧へ向けての基礎研究 柱3 エイズの血液免疫異常

    • Principal Investigator
      森 茂郎
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  HIVーenv 遺伝子発現ヒト細胞株を用いたHIV感染致死機構の研究Principal Investigator

    • Principal Investigator
      古賀 泰裕
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  マウスポックスにおける初期防御の解析

    • Principal Investigator
      木村 元喜
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Kyushu University
  •  The role of Lck in TCR-CD4 receptor signalingPrincipal Investigator

    • Principal Investigator
      KOGA Yasuhiro
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      KYUSHU UNIVERSITY
  •  アデノウイルスによる形質転換細胞のジアシルグリセロ-ルによる選択的破壊とその応用

    • Principal Investigator
      木村 元喜
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyushu University
  •  HIVーenv遺伝子発現ヒト細胞株を用いたHIV感染致死機構の研究Principal Investigator

    • Principal Investigator
      古賀 泰裕
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  HTLVーI発がんにおけるT細胞特異的チロシンキナーゼ遺伝子(lck)の役割Principal Investigator

    • Principal Investigator
      古賀 泰裕
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyushu University
  •  HIV-env遺伝子発現ヒト細胞株を用いたHIV感染致死機構の研究Principal Investigator

    • Principal Investigator
      古賀 泰裕
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University

All 2019 2017 2016 2015 2014 2013 2012 2011 2010 2009 2004

All Journal Article

  • [Journal Article] The Gut Microbiome Derived From Anorexia Nervosa Patients Impairs Weight Gain and Behavioral Performance in Female Mice2019

    • Author(s)
      Hata Tomokazu、Miyata Noriyuki、Takakura Shu、Yoshihara Kazufumi、Asano Yasunari、Kimura-Todani Tae、Yamashita Makoto、Zhang Xue-Ting、Watanabe Natsuru、Mikami Katsunaka、Koga Yasuhiro、Sudo Nobuyuki
    • Journal Title

      Endocrinology

      Volume: 160 Issue: 10 Pages: 2441-2452

    • DOI

      10.1210/en.2019-00408

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07611, KAKENHI-PROJECT-19K17072, KAKENHI-PLANNED-16H06404, KAKENHI-PROJECT-16H05278
  • [Journal Article] Regulation of gut luminal serotonin by commensal microbiota in mice.2017

    • Author(s)
      Hata T, Asano Y, Yoshihara K, Kimura-Todani T, Miyata N, Zhang XT, Takakura S, Aiba Y, Koga Y, Sudo N.
    • Journal Title

      PLoS One.

      Volume: 6;12(7) Issue: 7 Pages: e0180745-e0180745

    • DOI

      10.1371/journal.pone.0180745

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05278, KAKENHI-PROJECT-16K15413
  • [Journal Article] Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants.2016

    • Author(s)
      Koga Y, Tokunaga S, Nagano J, Sato F, Konishi K, Tochio T, Murakami Y, Masumoto N, Tezuka JI, Sudo N, Kubo C, Shibata R.
    • Journal Title

      Pediatr Res

      Volume: 80(6) Issue: 6 Pages: 844-851

    • DOI

      10.1038/pr.2016.167

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15276, KAKENHI-PROJECT-16K15413, KAKENHI-PROJECT-16H05278
  • [Journal Article] Influence of Proton-Pump Inhibitors on the Luminal Microbiota in the Gastrointestinal Tract.2015

    • Author(s)
      Tsuda A, Suda W, Morita H, Takanashi K, Takagi A, Koga Y, Hattori M.
    • Journal Title

      Clin Transl Gastroenterol.

      Volume: 11;6 Issue: 6 Pages: e89-e89

    • DOI

      10.1038/ctg.2015.20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293054, KAKENHI-PROJECT-25293167
  • [Journal Article] H.pylori感染症に対するプロバイオティクス2014

    • Author(s)
      古賀 泰裕
    • Journal Title

      感染症内科

      Volume: 2(4) Pages: 424-430

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293167
  • [Journal Article] 【Bacterial translocationと諸疾患】 Bacterial translocationとプロバイオティクス2014

    • Author(s)
      古賀 泰裕
    • Journal Title

      G.I.Research

      Volume: 22(4) Pages: 343-348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293167
  • [Journal Article] Commensal microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based methods.2013

    • Author(s)
      R. Nishino, K. Mikami, H. Takahashi, S. Tomonaga, M. Furuse, T. Hiramoto, Y. Aiba, Y. Koga, N. Sudo
    • Journal Title

      Neurogastroenterology & Motility

      Volume: 25(6) Issue: 6 Pages: 521-528

    • DOI

      10.1111/nmo.12110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659350, KAKENHI-PROJECT-25293054, KAKENHI-PROJECT-25293167
  • [Journal Article] Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice2012

    • Author(s)
      Asano Y, Hiramoto T, Nishino R, Aiba Y, Kimura T, Yoshihara K, Koga Y, Sudo N.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 303(11) Issue: 11 Pages: G1288-G1295

    • DOI

      10.1152/ajpgi.00341.2012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659350
  • [Journal Article] The effect of probiotics on gastric mucosal permeability in humans administered with aspirin2012

    • Author(s)
      Akama F, Nishino R, Makino S, Kobayashi K, Kamikaseda K, Nagano J, Koga Y.
    • Journal Title

      Scand J Gastroenterol

      Volume: 46 Pages: 831-836

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659144
  • [Journal Article] Role of indigenous lactobacilli in gastrin-mediated Acid production in the mouse stomach2011

    • Author(s)
      Takahashi H, Nakano Y, Matsuoka T, Kumaki N, Asami Y, Koga Y.
    • Journal Title

      Appl Environ Microbiol

      Volume: 77 Pages: 6964-6971

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659144
  • [Journal Article] Comparative analysis of the properties of bifidobacterial isolates from fecal samples of mother-infant pairs2010

    • Author(s)
      Takahashi H, Mikami K, Nishino R, Matsuoka T, Kimura M, Koga Y.
    • Journal Title

      J Pediatr Gastroenterol Nutr

      Volume: 51 Pages: 653-60

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659144
  • [Journal Article] Long-term administration of probiotics to asymptomatic pre-school children for either the eradication or the prevention of helicobacter pylori Infection.2009

    • Author(s)
      Boonyaritichaikij S, Kuwabara K, J Nagano J, Kobayashi K, Koga Y
    • Journal Title

      Helicobacter 14

      Pages: 202-207

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390192
  • [Journal Article] Influence of maternal bifidobacterial microbiota on the establishment of intestinal bifidobacterial microbiota in infants2009

    • Author(s)
      Mikami K, Takahashi H, Kimura M, Isozaki M, Izuchi K, Shibuta R, Sudo N, Matsumoto H, Koga Y
    • Journal Title

      Pediatric Research 65

      Pages: 669-674

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390192
  • [Journal Article] CD1d-dependent regulation of bacterial colonization in the intestine2009

    • Author(s)
      Edward E.S. Nieuwenhuis, Tetsuya Matsumoto, Dicky Lindenbergh, Rob Willemsen, Arthur Kaser, Ytje Simons-Oosterhuis, Sylvia Brugman, Keizo Yamaguchi, Hiroki Ishikawa, Yuji Aiba, Yasuhiro Koga, Janneke Samsom, Kenshiro Oshima, Mami Kikuchi, Johanna C. Escher, Masahira Hattori, Andrew B. Onderdonk, Richard S. Blumberg
    • Journal Title

      Journal of Clinical Investigation (in print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591184
  • [Journal Article] Influence of maternal bifidobacterial microbiota on the establishment of intestinal bifidobacterial microbiota in infants2009

    • Author(s)
      Mikami K, Takahashi H, Kimura M, Isozaki M, Izuchi K, Shibata R, Sudo N, Matsumoto H, Koga Y
    • Journal Title

      Pediatric Research (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390192
  • [Journal Article] Clinical effects of kestose, a prebiotic oligosaccharide, on the treatment of atopic dermatitis in infants2009

    • Author(s)
      Shibata R, Kimura M, Takahashi H, Mikami K, Aiba Y, Takeda H, Koga Y
    • Journal Title

      Clin Exp Allergy 39

      Pages: 1397-1403

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390192
  • [Journal Article] Dietary nucleic acid and intestinal microbiota synergistically promote a shift in the Th1/Th2 balance toward Th1-skewed immunity.2004

    • Author(s)
      Sudo N., Aiba Y., Oyama N., Yu XN., Matsunaga M., Koga Y., Kubo C.
    • Journal Title

      International Archives of Allergy & Immunology. 135(2)

      Pages: 132-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390200
  • [Journal Article] Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice.2004

    • Author(s)
      Sudo N., Chida Y., Aiba Y., Sonoda J., Oyama N., Yu XN., Kubo C., Koga Y.
    • Journal Title

      Journal of Physiology. 558(Pt 1)

      Pages: 263-75

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390200
  • 1.  SUDO Nobuyuki (60304812)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 9 results
  • 2.  木村 元喜 (00031964)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  YOSHIHARA Kazufumi (20444854)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 1 results
  • 4.  KUBO Chiharu (80117100)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 5.  TAKAKURA SHU (40532859)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  古川 智一 (70617365)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  波夛 伴和 (10535983)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 8.  MATSUMOTO Tetsuya (10256688)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  ASANO Yasunari (30572945)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KAWAI KEISUKE (80325521)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  奥田 篤行 (90032193)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  森 茂郎 (30010424)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  高橋 秀実 (40221361)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  服部 俊夫 (30172935)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  森田 千尋 (30448419)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  山下 真 (40770805)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  服部 正平 (70175537)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  三上 克央 (90548504)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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