KOGA Yasuhiro 古賀泰裕

Researcher Number	60170221
Other IDs
Affiliation (based on the past Project Information) *help	2019: 東海大学, 医学部, 教授 1995 – 2017: 東海大学, 医学部, 教授 1993 – 1994: 東海大, 医, 教授 1990 – 1992: 九州大学, 生体防御医学研究所, 助教授 1989: 九州大学, 生体防御医学研究所, 助手
Review Section/Research Field	Principal Investigator Virology / Immunology Except Principal Investigator General internal medicine (including Psychosomatic medicine) / General internal medicine(including psychosomatic medicine) / Environmental physiology (including Physical medicine and Nutritional physiology) / Environmental physiology(including physical medicine and nutritional physiology) / 膠原病・アレルギー・感染症内科学 / Virology
Keywords	Principal Investigator HIV / gp160 / カルモジュリン / アポトーシス / CD4 / lung / latent infection / NO / iNOS / MCMV-DNA … More / reactivation / graft-versus-host reaction / cytomegalovirus / Ca^<2+> / TCR / Lck / チロシンキナーゼ / apoptosis / calmodulin / ERストレス / カルシウムイオン / ミトコンドリア / カルモジュリンキナーゼ / 再活性化 / 潜伏感染 / サイトメガロウイルス / 情報伝達 / チロシンキナ-ゼ / p56lck / LcK / Ca^+ / gp120 / 核膜孔 / env遺伝子 / 細胞傷害 / 核移行タンパク / gP160 / エイズ / CD4抗原 / エンベロ-プ / lck / T細胞 / HTLVーI … More Except Principal Investigator 腸内細菌 / ストレス / 無菌マウス / 脳腸相関 / Stress / メタボローム / 摂食障害 / 次世代シークエンサー / 神経性やせ症 / バクテリアル・トランスロケーション / 炎症性腸疾患 / セロトニン / バクテリアルトランスロケーション / Neuroinnune / Microbiota / 神経内分泌 / Germ-free mouse / Hypothalamic-pituitary-adrenal axis / Intestinal microbiota / 単一細菌マウス / HPA axis / 視床下部-下垂体-副腎軸 / ストレス反応 / 腸内フローラ / マイクロバイオーム / 神経性食欲不振症 / 不安 / 行動 / 環境生理学 / 腸管 / カテコラミン / 環境 / CD1d / 緑膿菌 / プロバイオティクス / germ-free / NKT細胞 / CDld / bacterial translocation / 腸管免疫 / 消化管免疫 / 感染症学 / 神経科学 / 生理学 / envelope / リンパ腫 / ウイルス中和 / キラーT細胞 / gp160 / HIV / EBウイルス / リンパ節 / 免疫不全 / レトロウイルス / CD4 / 細胞免疫 / リンパ装置 / アポプトーシス / 悪性リンパ腫 / エイズ / サイトメガロウイルス肺炎 / 生体防御機構 / γδ型T細胞 / αβ型T細胞 / インタ-フェロン / NK細胞 / マウスサイトメガロウイルス / マウスボックスウイルス / 癌細胞株 / 3Y1細胞 / E1A遺伝子 / リン脂質 / ジアシルグリセロ-ル / 制癌剤 Less

Stress causes bacterial translocation: Analysis by high sensitive measurement method
- Principal Investigator
  
  Sudo Nobuyuki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kyushu University
Elucidation of pathophysiology of anorexia nervosa and creation of new paradigm: Control of body weight and behavioral characteristics by intestinal bacteria
- Principal Investigator
  
  Sudo Nobuyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kyushu University
How do gut microbes affect host behaviors?
- Principal Investigator
  
  Sudo Nobuyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  Kyushu University
Microbiome and metabolome analysis in patients with anorexia nervosa
- Principal Investigator
  
  Kubo Chiharu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Kyushu University
How does stressor make the hosts susceptible to bacterial infection?
- Principal Investigator
  
  SUDO Nobuyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kyushu University
Do gut microbiota affect body weight gain in patients with anorexia nervosa?
- Principal Investigator
  
  SUDO Nobuyuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kyushu University
Gut microbiota and Host Stress Response
- Principal Investigator
  
  KUBO Chiharu
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kyushu University
Mutual interaction of enteric bacteria and immune cells of the gut
- Principal Investigator
  
  MATSUMOTO Tetsuya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Tokyo Medical University
Change in emotional behavior following postnatal microbial colonization
- Principal Investigator
  
  KUBO Chiharu
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kyushu University
Regulation of hypothalamic-pituitary-adrenal system for stress response by intestinal microbiota
- Principal Investigator
  
  KUBO Chiharu
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Kyushu University
The role of calmodulin in the determination of cell death by viral infectionPrincipal Investigator
- Principal Investigator
  
  KOGA Yasuhiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Tokai University
HIV-envによる免疫不全発生の解明Principal Investigator
- Principal Investigator
  
  古賀泰裕
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
The role of nitric oxide in thereactivation of latently infected cytomegalovirusPrincipal Investigator
- Principal Investigator
  
  KOGA Yasuhiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Tokai University
HIV-envによる免疫不全発生機序の解明Principal Investigator
- Principal Investigator
  
  古賀泰裕
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
HIV-envによる免疫不全発生機序の解明Principal Investigator
- Principal Investigator
  
  古賀泰裕
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokai University
エイズ制圧へ向けての基礎研究柱3 エイズの血液免疫異常
- Principal Investigator
  
  森茂郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
HIVーenv 遺伝子発現ヒト細胞株を用いたHIV感染致死機構の研究Principal Investigator
- Principal Investigator
  
  古賀泰裕
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
マウスポックスにおける初期防御の解析
- Principal Investigator
  
  木村元喜
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kyushu University
The role of Lck in TCR-CD4 receptor signalingPrincipal Investigator
- Principal Investigator
  
  KOGA Yasuhiro
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  KYUSHU UNIVERSITY
アデノウイルスによる形質転換細胞のジアシルグリセロ-ルによる選択的破壊とその応用
- Principal Investigator
  
  木村元喜
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
HIVーenv遺伝子発現ヒト細胞株を用いたHIV感染致死機構の研究Principal Investigator
- Principal Investigator
  
  古賀泰裕
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
HTLVーI発がんにおけるT細胞特異的チロシンキナーゼ遺伝子(lck)の役割Principal Investigator
- Principal Investigator
  
  古賀泰裕
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
HIV-env遺伝子発現ヒト細胞株を用いたHIV感染致死機構の研究Principal Investigator
- Principal Investigator
  
  古賀泰裕
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University

All 2019 2017 2016 2015 2014 2013 2012 2011 2010 2009 2004

All Journal Article

[Journal Article] The Gut Microbiome Derived From Anorexia Nervosa Patients Impairs Weight Gain and Behavioral Performance in Female Mice2019
- Author(s)
  Hata Tomokazu、Miyata Noriyuki、Takakura Shu、Yoshihara Kazufumi、Asano Yasunari、Kimura-Todani Tae、Yamashita Makoto、Zhang Xue-Ting、Watanabe Natsuru、Mikami Katsunaka、Koga Yasuhiro、Sudo Nobuyuki
- Journal Title
  
  Endocrinology
  
  Volume: 160 Issue: 10 Pages: 2441-2452
- DOI
  10.1210/en.2019-00408
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07611, KAKENHI-PROJECT-19K17072, KAKENHI-PLANNED-16H06404, KAKENHI-PROJECT-16H05278
[Journal Article] Regulation of gut luminal serotonin by commensal microbiota in mice.2017
- Author(s)
  Hata T, Asano Y, Yoshihara K, Kimura-Todani T, Miyata N, Zhang XT, Takakura S, Aiba Y, Koga Y, Sudo N.
- Journal Title
  
  PLoS One.
  
  Volume: 6;12(7) Issue: 7 Pages: e0180745-e0180745
- DOI
  10.1371/journal.pone.0180745
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05278, KAKENHI-PROJECT-16K15413
[Journal Article] Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants.2016
- Author(s)
  Koga Y, Tokunaga S, Nagano J, Sato F, Konishi K, Tochio T, Murakami Y, Masumoto N, Tezuka JI, Sudo N, Kubo C, Shibata R.
- Journal Title
  
  Pediatr Res
  
  Volume: 80(6) Issue: 6 Pages: 844-851
- DOI
  10.1038/pr.2016.167
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15276, KAKENHI-PROJECT-16K15413, KAKENHI-PROJECT-16H05278
[Journal Article] Influence of Proton-Pump Inhibitors on the Luminal Microbiota in the Gastrointestinal Tract.2015
- Author(s)
  Tsuda A, Suda W, Morita H, Takanashi K, Takagi A, Koga Y, Hattori M.
- Journal Title
  
  Clin Transl Gastroenterol.
  
  Volume: 11;6 Issue: 6 Pages: e89-e89
- DOI
  10.1038/ctg.2015.20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293054, KAKENHI-PROJECT-25293167
[Journal Article] H.pylori感染症に対するプロバイオティクス2014
- Author(s)
  古賀　泰裕
- Journal Title
  
  感染症内科
  
  Volume: 2(4) Pages: 424-430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293167
[Journal Article] 【Bacterial translocationと諸疾患】 Bacterial translocationとプロバイオティクス2014
- Author(s)
  古賀　泰裕
- Journal Title
  
  G.I.Research
  
  Volume: 22(4） Pages: 343-348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293167
[Journal Article] Commensal microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based methods.2013
- Author(s)
  R. Nishino, K. Mikami, H. Takahashi, S. Tomonaga, M. Furuse, T. Hiramoto, Y. Aiba, Y. Koga, N. Sudo
- Journal Title
  
  Neurogastroenterology & Motility
  
  Volume: 25(6) Issue: 6 Pages: 521-528
- DOI
  10.1111/nmo.12110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659350, KAKENHI-PROJECT-25293054, KAKENHI-PROJECT-25293167
[Journal Article] Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice2012
- Author(s)
  Asano Y, Hiramoto T, Nishino R, Aiba Y, Kimura T, Yoshihara K, Koga Y, Sudo N.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 303(11) Issue: 11 Pages: G1288-G1295
- DOI
  10.1152/ajpgi.00341.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659350
[Journal Article] The effect of probiotics on gastric mucosal permeability in humans administered with aspirin2012
- Author(s)
  Akama F, Nishino R, Makino S, Kobayashi K, Kamikaseda K, Nagano J, Koga Y.
- Journal Title
  
  Scand J Gastroenterol
  
  Volume: 46 Pages: 831-836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659144
[Journal Article] Role of indigenous lactobacilli in gastrin-mediated Acid production in the mouse stomach2011
- Author(s)
  Takahashi H, Nakano Y, Matsuoka T, Kumaki N, Asami Y, Koga Y.
- Journal Title
  
  Appl Environ Microbiol
  
  Volume: 77 Pages: 6964-6971
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659144
[Journal Article] Comparative analysis of the properties of bifidobacterial isolates from fecal samples of mother-infant pairs2010
- Author(s)
  Takahashi H, Mikami K, Nishino R, Matsuoka T, Kimura M, Koga Y.
- Journal Title
  
  J Pediatr Gastroenterol Nutr
  
  Volume: 51 Pages: 653-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659144
[Journal Article] Long-term administration of probiotics to asymptomatic pre-school children for either the eradication or the prevention of helicobacter pylori Infection.2009
- Author(s)
  Boonyaritichaikij S, Kuwabara K, J Nagano J, Kobayashi K, Koga Y
- Journal Title
  
  Helicobacter 14
  
  Pages: 202-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390192
[Journal Article] Influence of maternal bifidobacterial microbiota on the establishment of intestinal bifidobacterial microbiota in infants2009
- Author(s)
  Mikami K, Takahashi H, Kimura M, Isozaki M, Izuchi K, Shibuta R, Sudo N, Matsumoto H, Koga Y
- Journal Title
  
  Pediatric Research 65
  
  Pages: 669-674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390192
[Journal Article] CD1d-dependent regulation of bacterial colonization in the intestine2009
- Author(s)
  Edward E.S. Nieuwenhuis, Tetsuya Matsumoto, Dicky Lindenbergh, Rob Willemsen, Arthur Kaser, Ytje Simons-Oosterhuis, Sylvia Brugman, Keizo Yamaguchi, Hiroki Ishikawa, Yuji Aiba, Yasuhiro Koga, Janneke Samsom, Kenshiro Oshima, Mami Kikuchi, Johanna C. Escher, Masahira Hattori, Andrew B. Onderdonk, Richard S. Blumberg
- Journal Title
  
  Journal of Clinical Investigation (in print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591184
[Journal Article] Influence of maternal bifidobacterial microbiota on the establishment of intestinal bifidobacterial microbiota in infants2009
- Author(s)
  Mikami K, Takahashi H, Kimura M, Isozaki M, Izuchi K, Shibata R, Sudo N, Matsumoto H, Koga Y
- Journal Title
  
  Pediatric Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390192
[Journal Article] Clinical effects of kestose, a prebiotic oligosaccharide, on the treatment of atopic dermatitis in infants2009
- Author(s)
  Shibata R, Kimura M, Takahashi H, Mikami K, Aiba Y, Takeda H, Koga Y
- Journal Title
  
  Clin Exp Allergy 39
  
  Pages: 1397-1403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390192
[Journal Article] Dietary nucleic acid and intestinal microbiota synergistically promote a shift in the Th1/Th2 balance toward Th1-skewed immunity.2004
- Author(s)
  Sudo N., Aiba Y., Oyama N., Yu XN., Matsunaga M., Koga Y., Kubo C.
- Journal Title
  
  International Archives of Allergy ＆ Immunology. 135(2)
  
  Pages: 132-5
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390200
[Journal Article] Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice.2004
- Author(s)
  Sudo N., Chida Y., Aiba Y., Sonoda J., Oyama N., Yu XN., Kubo C., Koga Y.
- Journal Title
  
  Journal of Physiology. 558(Pt 1)
  
  Pages: 263-75
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390200

1. SUDO Nobuyuki (60304812)

# of Collaborated Projects: 9 results

# of Collaborated Products: 9 results
2. 木村元喜 (00031964)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. YOSHIHARA Kazufumi (20444854)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
4. KUBO Chiharu (80117100)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
5. TAKAKURA SHU (40532859)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 古川智一 (70617365)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 波夛伴和 (10535983)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. MATSUMOTO Tetsuya (10256688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. ASANO Yasunari (30572945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAWAI KEISUKE (80325521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 奥田篤行 (90032193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 森茂郎 (30010424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 高橋秀実 (40221361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 服部俊夫 (30172935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 森田千尋 (30448419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 山下真 (40770805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 服部正平 (70175537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 三上克央 (90548504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

KOGA Yasuhiro 古賀 泰裕

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The role of calmodulin in the determination of cell death by viral infectionPrincipal Investigator

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HIV-envによる免疫不全発生の解明Principal Investigator

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The role of nitric oxide in thereactivation of latently infected cytomegalovirusPrincipal Investigator

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HIV-envによる免疫不全発生機序の解明Principal Investigator

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HIV-envによる免疫不全発生機序の解明Principal Investigator

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KOGA Yasuhiro 古賀泰裕