Nishi Miyuki 西美幸

… Alternative Names

NISHI Miyuki 西美幸

TAKESHIMA Miyuki 竹島美幸

西美幸ニシミユキ

竹島美幸タケシマミユキ

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Researcher Number	60183894
Other IDs
External Links
Affiliation (Current)	2025: 京都大学, 薬学研究科, 研究員
Affiliation (based on the past Project Information) *help	2020 – 2024: 京都大学, 薬学研究科, 研究員 2019: 京都大学, 薬学研究科, 特定研究員 2018: 京都大学, 大学院薬学研究科, 研究員 2017: 京都大学, 健康長寿社会の総合医療開発ユニット, 特定准教授 2013 – 2014: 京都大学, 健康長寿社会の総合医療開発ユニット, 准教授 … More 2013: 京都大学, 大学院薬学研究科, ・研究員 2012: 京都大学, 薬学研究科(研究院), 研究員 2011: 京都大学, 大学院・薬学研究科, 研究員 2009 – 2011: Kyoto University, 薬学研究科, 研究員 2002: Kurume University, Instructor, 分子化学研究所, 助手 2001 – 2002: 久留米大学, 分子生命科学研究所, 助手 1999: 財団法人癌研究会, 癌研究所・細胞生物部, 研究員 1999: Japanese Foundation for Cancer Research, The Cancer Institute, Dept. of Cell Biology, Associate Member, 癌研究所・細胞生物部, 研究員 1998: 癌研究会, 癌研究所細胞生物部, 研究員 1994 – 1995: (財)東京都精神医学総合研究所, 神経化学研究部門, 主任研究員 Less
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Basic Section 59020:Sports sciences-related / Applied health science / Neurophysiology and muscle physiology / Neurophysiology and muscle physiology Except Principal Investigator Basic Section 59020:Sports sciences-related / Neurophysiology and muscle physiology / Biological Sciences
Keywords	Principal Investigator カルシウム / 骨格筋 / 小胞体 / リアノジン受容体 / 筋肉 / ノックアウトマウス / 筋小胞体 / ジーンターゲッティング / 筋収縮 / MG23 … More / Ca2+ signaling / knockout mice / junctophilin / チロシンリン酸化 / ジャンクトフィリン / シグナルシークエンストラップ法 / カルシウムシグナリング / long-term potentiation / knockout mouse / nociceptin receptor / nociceptin / 長期増強 / PhoN / Rhoファミリー / ナロキソンベンゾイルヒドラゾン / ノシセプチン受容体 / ノシセプチン / ミツグミン23 / オピオイド受容体 / 分子生物学 / カルシウムイオン / カルシウム放出チャンネル … More Except Principal Investigator ミツグミン23 / 不活動 / 筋疲労 / カルシウム漏出 / 筋小胞体 / 細胞内遊離Ca2+ / 骨格筋疲労 / スキンドファイバー / 高血圧 / リアノジン受容体 / 単粒子解析 / 脂質二重膜再構成 / TRIM50 / ミツグミン53 / Ca2+スパーク / ミツグミン２３ / 血管平滑筋 / 小胞体Ca2+放出 / TRICチャネル / 蛋白リン酸化 / シグナル伝達 / 受容体 / 神経細胞 / ジャンクトフィリン / シグナルシークエンストラップ法 / ノックアウトマウス / カルシウムシグナリング Less

Muscle contraction and calcium signalingPrincipal Investigator
- Principal Investigator
  
  西美幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Kyoto University
活動量の変化に伴う骨格筋の可塑的変化のメカニズムの解明
- Principal Investigator
  
  渡邊大輝
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Osaka University of Health and Sport Sciences
  National Cardiovascular Center Research Institute
Sarcoplasmic reticulum and contractionPrincipal Investigator
- Principal Investigator
  
  Nishi Miyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Kyoto University
Functional analysis of MG23 and MG56Principal Investigator
- Principal Investigator
  
  Nishi Miyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Kyoto University
Analysis of MG56: sarcoplasmic reticulum-resident proteinPrincipal Investigator
- Principal Investigator
  
  NISHI Miyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Kyoto University
Study of TRIC and MG23 channels
- Principal Investigator
  
  TAKESHIMA Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Kyoto University
Functional analysis of SR protein, Mitsugumin 23.Principal Investigator
- Principal Investigator
  
  NISHI Miyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Kyoto University
新規受容体蛋白ファミリーの機能解析
- Principal Investigator
  
  竹島浩
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
  Kurume University
Survey for novel signal transduction in the central nervous systemPrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Miyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kurume University
Research for neuronal peptidesPrincipal Investigator
- Principal Investigator
  
  TAKESHIMA Miyuki
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Japanese Foundation for Cancer Research
オピオイド受容体とリアノジン受容体の分子生物学的手法による機能解析Principal Investigator
- Principal Investigator
  
  竹島美幸
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Institute of Psychiatry
リアノジン受容体/カルシウム放出チャンネル遺伝子欠失マウスの作製と解析Principal Investigator
- Principal Investigator
  
  竹島美幸
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Psychiatry

[Book] TRIC チャネルと高血圧2013
- Author(s)
  山崎大樹、陶晟辰、竹島浩
- Publisher
  Clinical Calcium
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] Ca2+ storage function is altered in the sarcoplasmic reticulum of skeletal muscle lacking mitsugumin 232024
- Author(s)
 Watanabe Daiki、Nishi Miyuki、Liu Feng、Bian Yuhan、Takeshima Hiroshi
- Journal Title
 
 American Journal of Physiology-Cell Physiology
 
 Volume: 326 Issue: 3 Pages: C795-C809
- DOI
 10.1152/ajpcell.00440.2023
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-23K10634, KAKENHI-PROJECT-21H02663, KAKENHI-PROJECT-23K24738
[Journal Article] Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice2023
- Author(s)
  Ichimura Atsuhiko、Miyazaki Yuu、Nagatomo Hiroki、Kawabe Takaaki、Nakajima Nobuhisa、Kim Ga Eun、Tomizawa Masato、Okamoto Naoki、Komazaki Shinji、Kakizawa Sho、Nishi Miyuki、Takeshima Hiroshi
- Journal Title
  
  Cell Death and Disease
  
  Volume: 14 Issue: 12 Pages: 848-848
- DOI
  10.1038/s41419-023-06285-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18456, KAKENHI-PROJECT-23K06012, KAKENHI-PROJECT-23K10634, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K27378
[Journal Article] The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR22023
- Author(s)
  Hu J, Venturi E, Sigalas C, Murayama T, Nishi M, Takeshima H, Sitsapesan R.
- Journal Title
  
  J Gen Physiol.
  
  Volume: 155 Issue: 11
- DOI
  10.1085/jgp.202113070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K10634
[Journal Article] C-type natriuretic peptide facilitates autonomic Ca 2+ entry in growth plate chondrocytes for stimulating bone growth2022
- Author(s)
  Yuu Miyazaki#, Atsuhiko Ichimura#, Ryo Kitayama, Naoki Okamoto, Tomoki Yasue, Feng Liu, Takaaki Kawabe, Hiroki Nagatomo, Yohei Ueda, Ichiro Yamauchi, Takuro Hakata, Kazumasa Nakao, Sho Kakizawa, Miyuki Nishi, Yasuo Mori, Haruhiko Akiyama, Kazuwa Nakao, Hiroshi Takeshima
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.71931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03802, KAKENHI-PROJECT-21H02663, KAKENHI-PROJECT-21K19565, KAKENHI-PROJECT-19K06955, KAKENHI-PROJECT-20K11306, KAKENHI-PROJECT-21K19752
[Journal Article] Enhanced Ca2+ handling in thioglycolate-elicited peritoneal macrophages2021
- Author(s)
  Liu Feng、Xu Luxin、Nishi Miyuki、Ichimura Atsuhiko、Takeshima Hiroshi
- Journal Title
  
  Cell Calcium
  
  Volume: 96 Pages: 102381-102381
- DOI
  10.1016/j.ceca.2021.102381
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11306, KAKENHI-PROJECT-18H02597, KAKENHI-PROJECT-20H03802, KAKENHI-PROJECT-21H02663
[Journal Article] Decreased cardiac pacemaking and attenuated beta-adrenergic response in TRIC-A knockout mice.2020
- Author(s)
  Murakami M, Toyama Y, Yonekura M, Ohba T, Matsuzaki Y, Sawamura D, Murakami AM, Nishi M, Itagaki S, Tomita H, Takeshima H.
- Journal Title
  
  Plos ONE
  
  Volume: 15 Issue: 12 Pages: 1-12
- DOI
  10.1371/journal.pone.0244254
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07255, KAKENHI-PROJECT-20K08665, KAKENHI-PROJECT-20K11306, KAKENHI-PROJECT-17H04319, KAKENHI-PROJECT-18K08286
[Journal Article] TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle2020
- Author(s)
  Zhou X, Park KH, Yamazaki D, Lin PH, Nishi M, Ma Z, Qiu L, Murayama T, Zou X, Takeshima H, Zhou J, Ma J.
- Journal Title
  
  Circulation Reserach
  
  Volume: 126 Issue: 4 Pages: 417-435
- DOI
  10.1161/circresaha.119.316241
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07313, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-17K01845, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-18H02597
[Journal Article] Enhanced activity of multiple TRIC-B channels; an ER/SR mechanism to boost counterion currents.2019
- Author(s)
  O'Brien F, Eberhardt D, Witschas K, El-Ajouz S, Iida T, Nishi M, Takeshima H, Sitsapesan R, Venturi E.
- Journal Title
  
  J Physiol.
  
  Volume: 印刷中 Issue: 10 Pages: 2691-2705
- DOI
  10.1113/jp277241
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01845, KAKENHI-PROJECT-18H02597
[Journal Article] TRPM7 channels mediate spontaneous Ca2+ fluctuations in growth plate chondrocytes that promote bone development.2019
- Author(s)
  Qian N, Ichimura A, Takei D, Sakaguchi R, Kitani A, Nagaoka R, Tomizawa M, Miyazaki Y, Miyachi H, Numata T, Kakizawa S, Nishi M, Mori Y, Takeshima H.
- Journal Title
  
  Science signaling
  
  Volume: 12 Issue: 576 Pages: 4847-4847
- DOI
  10.1126/scisignal.aaw4847
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01845, KAKENHI-PROJECT-18H02597, KAKENHI-PROJECT-15K06774, KAKENHI-PROJECT-18K11044, KAKENHI-PROJECT-18K06864, KAKENHI-PROJECT-19K06955, KAKENHI-PROJECT-19K22834, KAKENHI-PUBLICLY-18H04695, KAKENHI-PROJECT-16K05843, KAKENHI-PLANNED-26111004, KAKENHI-PROJECT-17H06228
[Journal Article] Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A.2017
- Author(s)
  El-Ajouz S, Venturi E, Witschas K, Beech M, Wilson AD, Lindsay C, Eberhardt D, O'Brien F, Iida T, Nishi M, Takeshima H, Sitsapesan R.
- Journal Title
  
  J Physiol.
  
  Volume: 595 Issue: 14 Pages: 4769-4784
- DOI
  10.1113/jp273550
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01845, KAKENHI-PROJECT-15H04676
[Journal Article] Gm7325 is MyoD-dependently expressed in activated muscle satellite cells 2017
- Author(s)
 Takei D, Nishi M, Fukada S, Doi M, Okamura H, Uezumi A, Zhang L, Yoshida M, Miyazato M, Ichimura A, Takeshima H.
- Journal Title
 
 Biomed. Res.
 
 Volume: 38 Issue: 3 Pages: 215-219
- DOI
 10.2220/biomedres.38.215
- NAID
 130006865614
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-17K01845, KAKENHI-PLANNED-15H05933, KAKENHI-PROJECT-15H01843, KAKENHI-PROJECT-17H01524, KAKENHI-PROJECT-15H04676, KAKENHI-PROJECT-15H05652
[Journal Article] Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage.2017
- Author(s)
  Reilly-O'Donnell B, Robertson GB, Karumbi A, McIntyre C, Bal W, Nishi M, Takeshima H, Stewart AJ, Pitt SJ.
- Journal Title
  
  J Biol Chem.
  
  Volume: 292 Issue: 32 Pages: 13361-13373
- DOI
  10.1074/jbc.m117.781708
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01845
[Journal Article] Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.2015
- Author(s)
  Van B, Nishi M, Komazaki S, Ichimura A, Kakizawa S, Nakanaga K, Aoki J, Park KH, Ma J, Ueyama T, Ogata T, Maruyama N, Takeshima H.
- Journal Title
  
  FEBS Lett.
  
  Volume: in press Issue: 10 Pages: 1095-1104
- DOI
  10.1016/j.febslet.2015.03.028
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24500470, KAKENHI-PROJECT-15K06774, KAKENHI-PROJECT-15H04676, KAKENHI-PROJECT-15H05652
[Journal Article] TRIM72 is required for effective repair of alveolar epithelial cell wounding.2014
- Author(s)
  Kim SC, Kellett T, Wang S, Nishi M, Nagre N, Zhou B, Flodby P, Shilo K, Ghadiali SN, Takeshima H, Hubmayr RD, Zhao X.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 307 Issue: 6 Pages: L449-L459
- DOI
  10.1152/ajplung.00172.2014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500470
[Journal Article] Treatment of acute lung injury by targeting MG53-mediated cell membrane repair.2014
- Author(s)
  Jia Y, Chen K, Lin P, Lieber G, Nishi M, Yan R, Wang Z, Yao Y, Li Y, Whitson BA, Duann P, Li H, Zhou X, Zhu H, Takeshima H, Hunter JC, McLeod RL, Weisleder N, Zeng C, Ma J.
- Journal Title
  
  Nat Commun.
  
  Volume: 5 Issue: 1 Pages: 1-12
- DOI
  10.1038/ncomms5387
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500470
[Journal Article] Facilitated hyperpolarization signaling in vascular smooth muscle overexpressing TRIC-A channels.2013
- Author(s)
  Tao, S., Yamazaki, D., Komazaki, S., Zhao, C., Iida, T., Kakizawa, S., Imaizumi, Y. & Takeshima, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 22 Pages: 15581-15589
- DOI
  10.1074/jbc.m112.435396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240055, KAKENHI-PROJECT-23390020, KAKENHI-PROJECT-23659037, KAKENHI-PUBLICLY-24111528, KAKENHI-PROJECT-24659131, KAKENHI-PROJECT-24680041, KAKENHI-PUBLICLY-25136717
[Journal Article] TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model.2013
- Author(s)
  Venturi, E., Matyjaszkiewicz, A., Pitt, S. J., Tsaneva-Atanasova, K., Nishi, M., Yamazaki, D., Takeshima, H. & Sitsapesan, R.
- Journal Title
  
  Pflugers Arch.
  
  Volume: 465 Issue: 8 Pages: 1135-1148
- DOI
  10.1007/s00424-013-1251-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240055, KAKENHI-PROJECT-24500470, KAKENHI-PROJECT-24659131
[Journal Article] TRIC-B channels display labile gating : evidence from the TRIC-A knockout mouse model2013
- Author(s)
  Venturi, E., Matyjaszkiewicz, A., Pitt, S J., Tsaneva-Atanasova, K., Nishi, M., Yamazaki, D., Takeshima, H. & Sitsapesan, R
- Journal Title
  
  Pflugers Arch
  
  Volume: 465 Pages: 1135-1148
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] TRIC channels supporting efficient Ca^<2+> release from intracellular stores2013
- Author(s)
 Venturi, E., Sitsapesan, R., Yamazaki, D. & Takeshima, H
- Journal Title
 
 Pflugers Arch
 
 Volume: 465 Pages: 187-195
- Data Source
 KAKENHI-PROJECT-23240055
[Journal Article] Facilitated hyperpolarization signaling in vascular smooth muscle overexpressing TRIC-A channels2013
- Author(s)
  Tao, S., Yamazaki, D., Komazaki, S., Zhao, C., Iida, T., Kakizawa, S., Imaizumi, Y. & Takeshima, H
- Journal Title
  
  J. Biol. Chem
  
  Volume: 288 Pages: 15581-15589
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice.2013
- Author(s)
  Mosca B, Delbono O, Laura Messi M, Bergamelli L, Wang ZM, Vukcevic M, Lopez R, Treves S, Nishi M, Takeshima H, Paolini C, Martini M, Rispoli G, Protasi F, Zorzato F.
- Journal Title
  
  Nat. Commun.
  
  Volume: 4 Pages: 1541-1549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500470
[Journal Article] Enhanced dihydropyridine receptor calcium channel activity improves skeletal muscle strength2013
- Author(s)
  Mosca, B., Bergamelli, L., Vukcevic, M, Lopez, R., Treves, S., Nishi, M., Takeshima, H., Paolini, C., Martini, M., Rispoli, G., Protasi, F. & Zorzato, F
- Journal Title
  
  Nat. Commun
  
  Volume: 4 Pages: 1541-1541
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging2012
- Author(s)
  Delbono, O., Messi M. L., Wang, Z., Treves, S., Mosca, B., Bergamelli, L., Nishi, M., Takeshima, H., Shi H., Xue B. & Zorzato, F
- Journal Title
  
  Exp. Gerontol
  
  Volume: 4 Issue: 4 Pages: 304-316
- DOI
  10.1016/j.exger.2012.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500382, KAKENHI-PROJECT-22659066, KAKENHI-PROJECT-24500470
[Journal Article] TRIM50 regulates vesicular trafficking for acid secretion in gastric parietal cells2012
- Author(s)
  Nishi, M., Aoyama, F., Kisa, F., Zhu, H., Sun, M., Lin, P., Ohta, H., Yamamoto, S., Kakizawa, S., Sakai, H., Ma, J., Sawaguchi, A. & Takeshima, H
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287 Pages: 33523-33532
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity2012
- Author(s)
  Jiao, Q., Takeshima, H., Ishikawa, Y. & Minamisawa, S
- Journal Title
  
  Cell Calcium
  
  Volume: 51 Pages: 31-39
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] TRIM50 regulates vesicular trafficking for acid secretion in gastric parietal cells.2012
- Author(s)
  Nishi, M., Aoyama, F., Kisa, F., Zhu, H., Sun, M., Lin, P., Ohta, H., Yamamoto, S., Kakizawa, S., Sakai, H., Ma, J., Sawaguchi, A. & Takeshima, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Issue: 40 Pages: 33523-33532
- DOI
  10.1074/jbc.m112.370551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240055, KAKENHI-PROJECT-24500470, KAKENHI-PROJECT-24659095, KAKENHI-PROJECT-24790073
[Journal Article] Recombinant human MG53 protein modulates therapeutic cell membrane repair.2012
- Author(s)
  Weisleder N, Takizawa N, Lin P, Wang X, Cao C, Zhang Y, Tan T, Ferrante C, Zhu H, Chen P-J, Yan R, Sterling M, Zhao X, Hwang M, Cai C, Cheng H, Takeshima H, Xiao R. & Ma J.
- Journal Title
  
  Sci. Transl. Med.
  
  Volume: 4 Issue: 139 Pages: 1-10
- DOI
  10.1126/scitranslmed.3003921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240055, KAKENHI-PROJECT-24500470
[Journal Article] Mitsugumin 23 forms massive bowl-shaped assembly and cation-selective channel2011
- Author(s)
  Venturi, E., Mio, K., Nishi, M., Ogura, T., Moriya, T., Okuda, K., Kakizawa, S., Sitapeasan, R., Chikara Sato, C. & Takeshima, H
- Journal Title
  
  Biochemistry
  
  Volume: 50 Pages: 2623-2632
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance2011
- Author(s)
  Yamazaki, D., Tabara, Y., Kita, S., Hanada, H., Komazaki, S., Naitou, D., Mishima, A., Nishi, M., Yamamura, H., Yamamoto, S., Kakizawa, S., Miyachi, H., Yamamoto, S., Miyata, T., Kawano, Y., Kamide, K., Ogihara, T., Hata, A., Umemura, S., Soma, M., Takahashi, N., Imaizumi, Y., Miki, T., Iwamoto, T. & Takeshima, H
- Journal Title
  
  Cell Metab
  
  Volume: 14 Pages: 231-241
- NAID
  120003255678
- Data Source
  KAKENHI-PROJECT-23240055
[Journal Article] Mitsugumin 23 forms a massive bowl shaped assembly and cation-conducting channel2011
- Author(s)
  Elisa Venruti, Kazuhiro Mio, Miyuki Nishi, Toshihiko Ogura, Toshio Moriya, Samantha Pitt, Kazutaka Okuda, Sho Kakizawa, Rebecca Sitsapesan, Chikara Sato and Hiroshi Takeshima
- Journal Title
  
  Biochemistry
  
  Volume: Vol.50 Issue: 13 Pages: 2623-2632
- DOI
  10.1021/bi1019447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300107, KAKENHI-PROJECT-21500382, KAKENHI-PLANNED-22121004, KAKENHI-PROJECT-23659037
[Journal Article] MG53 constitutes a primary determinant of cardiac ischemic preconditioning2010
- Author(s)
  Cao, CM., Zhang, Y., Weisleder, N., Ferrante, C., Wang, X., Lv, F., Zhang, Y., Song, R., Hwang, M., Jin, L., Guo, J., Peng, W., Li, G., Nishi, M., Takeshima, H., Ma, J. & Xiao, RP
- Journal Title
  
  Circulation
  
  Volume: 121 Issue: 23 Pages: 2565-2574
- DOI
  10.1161/circulationaha.110.954628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500382
[Journal Article] two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel2010
- Author(s)
  Pitt, S. J., Park, KH, Nishi M., Urashima, T., Aoki, S., Yamazaki, D., Ma, J., Takeshima, H. & Sitsapesan R. Charade of the SR K+-channel
- Journal Title
  
  Biophys. J.
  
  Volume: 99 Issue: 2 Pages: 417-426
- DOI
  10.1016/j.bpj.2010.04.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500382, KAKENHI-PROJECT-22790209
[Journal Article] Ca2+ overload and sarcoplasmic reticulum instability in tric-a null skeletal muscle2010
- Author(s)
  Zhao, X., Yamazaki, D., Park, KH., Komazaki, S., Tjondrokoesoemo, A., Nishi, M., Lin, P., Hirata, Y., Brotto, M., Takeshima, H & Ma, J.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Issue: 48 Pages: 37370-37376
- DOI
  10.1074/jbc.m110.170084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500382, KAKENHI-PROJECT-22790209
[Journal Article] Facilitation of DNA damage-induced apoptosis by endplasmic reticulum protein mitsugumin232010
- Author(s)
  Yamazaki, T., Sasaki, N., Nishi, M. & Takeshima, H.
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 392 Issue: 2 Pages: 196-200
- DOI
  10.1016/j.bbrc.2010.01.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500382
[Journal Article] MG53 is an essential component of the acute membrane repair machinery2009
- Author(s)
  Cai, C., Masumiya, H., Weisleder, N., Matsuda, N., Nishi, M., Hwang, M., Ko, JK., Lin, P., Thornton, A., Zhao, X., Pan, Z., Komazaki, S., Brotto, M., Takeshima, H & Ma, J.
- Journal Title
  
  Nature cell biol
  
  Volume: 11 Issue: 1 Pages: 56-64
- DOI
  10.1038/ncb1812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500382
[Journal Article] Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and inperinatal lung maturation2009
- Author(s)
  Yamazaki, D., Komazaki, S., Nakanishi, H., Mishima, A., Nishi, M., Yazawa, M., Yamazaki, T., Taguchi, R & Takeshima H.
- Journal Title
  
  Development
  
  Volume: 136 Issue: 14 Pages: 2355-2361
- DOI
  10.1242/dev.036798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500382
[Journal Article] MG53 regulates membrane budding in muscle cells.2009
- Author(s)
  Cai, C., Masumiya, H., Weisleder, N., Pan, Z., Nishi, M., Komazaki, S., Takeshima, H & Ma, J.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 284 Issue: 5 Pages: 3314-3322
- DOI
  10.1074/jbc.m808866200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500382
[Journal Article] Membrane repair defects muscular dystrophy are linked to alterd interaction between MG53, caveolin-3 and dysferlin2009
- Author(s)
  Cai, C., Weisleder, N., Ko, JK., Komazaki, S., Sunada, Y., Nishi, M., Takeshima, H. & Ma, J
- Journal Title
  
  J. Biol. Chem
  
  Volume: 284 Issue: 23 Pages: 15894-15902
- DOI
  10.1074/jbc.m109.009589
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500382
[Presentation] Role of Mitsugumin 23 in Ca2+ storage of sarcoplasmic reticulum in type I and type II fibers of the mice2023
- Author(s)
 Watanabe Daiki、Nishi Miyuki、Liu Feng、Takeshima Hiroshi
- Organizer
 50th European Muscle Conference
- Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-23K24738
[Presentation] Contribution of Mitsugumin 23 to Ca2+ leakage of sarcoplasmic reticulum in skeletal muscle fibers2023
- Author(s)
 Watanabe Daiki、Nishi Miyuki、Liu Feng、Takeshima Hiroshi
- Organizer
 Gordon Research Conference Muscle: Excitation-contraction coupling
- Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-23K24738
[Presentation] ミツグミン23が骨格筋疲労に及ぼす影響2022
- Author(s)
  渡邊大輝，西美幸，竹島浩
- Organizer
  第8回日本筋学会
- Data Source
  KAKENHI-PROJECT-23K24738
[Presentation] ミツグミン２３が筋披露に及ぼす影響2022
- Author(s)
  渡邉　大輝、西　美幸、竹島　浩
- Organizer
  第８回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-20K11306
[Presentation] TRIC-A Channel Modulates Ca2+ Homeostasis in Mitochondria2020
- Author(s)
  Ang Li, Xuejun Li, Jianxun Yi, Xinyu Zhou, Ki Ho Park, Miyuki Nishi, Hiroshi Takeshima, Jianjie Ma, Jingsong Zhou
- Organizer
  Biophysical society annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01845
[Presentation] Spontaneous Ca2+ Fluctuations mediated by TRPM7 channels2018
- Author(s)
  Qian N, Ichimura A, Takei D, Zhu H, Nishi M, Takeshima H
- Organizer
  62nd annual meeting Biophysical society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01845
[Presentation] GM7325 Transcription is regulated by nyoD in activated muscle satellite cells.2018
- Author(s)
  Takei D, Nishi M, Fukada S, Doi M, Okamura H, Uezumi A, Zhang L, Yoshida M, Miyazato M, Ichimura A, Takeshima H.
- Organizer
  62nd annual meeting Biophysical society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01845
[Presentation] The MBOAT family protein Mitsugumin 56 contributes to postnatal maturation in the muscle sarcoplasmic reticulum.2014
- Author(s)
  Van, B., Nishi, M., Komazaki, S., Park, K. H., Yamazaki, D., Ma, J. & Takeshima, H.
- Organizer
  Biophysical Society 58th annual meeting
- Place of Presentation
  Sanfrancisco, CA, USA
- Data Source
  KAKENHI-PROJECT-24500470
[Presentation] TRIM50 regulates ventricular trafficking for acid secretion in gastric parietal cells.2013
- Author(s)
  Nishi, M., Aoyama, F., Kisa, F., Zhu, H., Sun, M., Lin, P., Van, Bo., Ma, J., Sawaguchi, A., & Takeshima, H.
- Organizer
  Biophysical Society 57th annual Meeting
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-24500470
[Presentation] TRIC channels are essential partners for Ca^<2+> release2012
- Author(s)
 Takeshima, H
- Organizer
 European Calcium Channel Conference
- Place of Presentation
 Alpbach, Austria
- Year and Date
 2012-05-19
- Data Source
 KAKENHI-PROJECT-23240055
[Presentation] Up regulation of calcium influx via Cav11 in skeletal muscle fibers from JP-45 calsequestrin 1 double knock out mice2012
- Author(s)
 Barbara Mosca, Leda Bergamelli, Mirko Vukcevic, Susan Treves, Cecilia Paoloni, Miyuki Nishi, Hiroshi Takeshima, Feliciano Protasi & Francesco Zorzato
- Organizer
 Biophysical Society 56^<th> Annual meeting
- Place of Presentation
 San Diego, California(USA)
- Data Source
 KAKENHI-PROJECT-21500382
[Presentation] TRIC channels supporting physiological Ca^<2+> release2012
- Author(s)
 Takeshima, H
- Organizer
 Gordon Research Conference; muscle E-C coupling
- Place of Presentation
 Les Diablerets, Switzerland
- Year and Date
 2012-06-04
- Data Source
 KAKENHI-PROJECT-23240055
[Presentation] Upregulation of calcium influx via Cavl.1 in skeletal muscle fibers from JP45 calsequestrin 1 double knock out mice2012
- Author(s)
  Zorsat F.…Nishi M., 他5名
- Organizer
  Biophysical Society 56th annual meeting
- Place of Presentation
  サンディエゴ(アメリカ)
- Year and Date
  2012-02-26
- Data Source
  KAKENHI-PROJECT-21500382
[Presentation] TRIC channel subtypes, willing partners with Ca2+ release channels in intracellular stores2011
- Author(s)
  Takeshima, H.
- Organizer
  Gordon Research Conference ; Ca2+ signaling
- Place of Presentation
  Watervilie Valley, USA(招待講演)
- Year and Date
  2011-06-27
- Data Source
  KAKENHI-PROJECT-23240055
[Presentation] TRIC channel subtypes, willing partners with Ca^<2+> release channels in intracellular stores2011
- Author(s)
 Takeshima, H
- Organizer
 Gordon Research Conference; Ca^<2+> signaling
- Place of Presentation
 Waterville Valley, USA
- Year and Date
 2011-06-27
- Data Source
 KAKENHI-PROJECT-23240055
[Presentation] Rebbeca Sitsapesan, Chikara sato & Hiroshi Takeshima. Mitsugumin23, a protein associated with intracellular calcium stores, behaves as an ion-channel that can conduct calcium2011
- Author(s)
 Kazuhiro Mio, Miyuki Nishi, Toshihiko Ogura, Toshio Moriya, Samantha J. Pitt, Kazutaka Okuda
- Organizer
 Biophysical Society 55^<th> Annual meeting
- Place of Presentation
 Baltimore, Maryland(USA)
- Data Source
 KAKENHI-PROJECT-21500382
[Presentation] TRIC channels and vascular tonus
- Author(s)
  Takeshima, H.
- Organizer
  Gordon Research Conference; Ca2+ signaling
- Place of Presentation
  Tuscany Il Ciocco Resorts, Lucca, Italy
- Data Source
  KAKENHI-PROJECT-23240055
[Presentation] Mitsugumin 56 is an MBOAT family member and contributes to postnatal muscle maturation
- Author(s)
  Nishi M, Van B, Komazaki S, Yamazaki D, Park KH, Ma J, Takeshima H
- Organizer
  biophysical society 59th annual meeting
- Place of Presentation
  Baltimore, USA
- Year and Date
  2015-02-07 – 2015-02-11
- Data Source
  KAKENHI-PROJECT-24500470
[Presentation] TRIC channels supporting physiological Ca2+ release.
- Author(s)
  Hiroshi Takeshima
- Organizer
  Gordon Research Conference; muscle E-C coupling
- Place of Presentation
  Les Diablerets, Switzerland
- Invited
- Data Source
  KAKENHI-PROJECT-23240055
[]

1. TAKESHIMA Hiroshi (70212024)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
2. 東郷暁 (40282123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 伊藤公一 (50330874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 山崎大樹 (40467428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 渡邊大輝 (30823281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 和田正信 (80220961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 市村敦彦 (10609209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. OGURA Toshihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 植田洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 村上学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 柿澤昌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishi Miyuki 西 美幸

NISHI Miyuki 西 美幸

TAKESHIMA Miyuki 竹島 美幸

西 美幸 ニシ ミユキ

竹島 美幸 タケシマ ミユキ

Research Projects

Research Products

Co-Researchers

Muscle contraction and calcium signalingPrincipal Investigator

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活動量の変化に伴う骨格筋の可塑的変化のメカニズムの解明

Principal Investigator

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Sarcoplasmic reticulum and contractionPrincipal Investigator

Principal Investigator

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Review Section

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Functional analysis of MG23 and MG56Principal Investigator

Principal Investigator

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Research Institution

Analysis of MG56: sarcoplasmic reticulum-resident proteinPrincipal Investigator

Principal Investigator

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Research Institution

Study of TRIC and MG23 channels

Principal Investigator

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Functional analysis of SR protein, Mitsugumin 23.Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

新規受容体蛋白ファミリーの機能解析

Principal Investigator

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Survey for novel signal transduction in the central nervous systemPrincipal Investigator

Principal Investigator

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Research Institution

Research for neuronal peptidesPrincipal Investigator

Principal Investigator

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オピオイド受容体とリアノジン受容体の分子生物学的手法による機能解析Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

リアノジン受容体/カルシウム放出チャンネル遺伝子欠失マウスの作製と解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] TRIC チャネルと高血圧2013

Nishi Miyuki 西美幸

NISHI Miyuki 西美幸

TAKESHIMA Miyuki 竹島美幸

西美幸ニシミユキ

竹島美幸タケシマミユキ