OHNO Takashi 大野隆

Researcher Number	60185345
External Links
Affiliation (based on the past Project Information) *help	2006 – 2010: 北里大学, 医学部, 非常勤講師 1999 – 2000: 北里大学, 医学部, 助手 1992 – 1996: 北里大学, 医学部, 助手 1994: 北里大学医学部, 助手
Review Section/Research Field	Principal Investigator 応用薬理学・医療系薬学 / Gastroenterology Except Principal Investigator 応用薬理学・医療系薬学 / General pharmacology
Keywords	Principal Investigator CGRP / 胃粘膜微小循環 / PGI_2 / PGE_2 / Substance P / Neuropeptide / Prostaglandin E2 / Gastric Mucosal Microcirculation / Knockout Mice / Ethanol-Induced Gastric Mucosal Injury … More / Adaptive Cytoprotection / 胃粘膜基底部微小循環 / ノックアウトマウス / アダプティブサイトプロテクション / エタノール胃粘膜傷害 / CD31 / VEGF / カプサイシン / エタノール / 微小循環 / 潰瘍 / 胃粘膜障害 / VEGF-A / 血管新生 / 潰瘍治癒 / CGRPノックアウトマウス / 一次求心性知覚神経 / 粘膜傷害修復 / 胃粘膜恒常性維持作用 / 1 M NaCl / 1MNaCl / EP receptor / Nitric Oxide(NO) / Prostacyclin(PGI_2) / BQ-123 / Sarafotoxin S6c / Endothelin-3 / Endothelin-1 … More Except Principal Investigator carboxypeptidase Y / ebelactone B / ICAM-1 / CD_<18> / CD_<11> / spontaneously hypertensive rats / DOCA-salt hypertension / Brown Norway rats / kininase / kininogen / renal kallikrein / ポストスタチン / スピロノラクトン / アルドステロン / 食塩による高血圧発症 / アンギオテンシンII / 尿カリクレイン / ナトリウム利尿 / oxytocin / neutral endopeptidase / 尿キニナーゼ阻害薬 / 実験的高血圧 / キニノゲン欠損ラット / DOCA-食塩高血圧 / 自然発症高血圧ラット / DOCA‐食塩高血圧 / Brown Norwayラット / カルボキシペプチダーゼY / キニナーゼ / キニノゲン / 腎カリクレイン / Kallikrein / Gastric Mucosal Injury / Adhesion Molecules / 5-Lipoxygenase / Leukotriene C_4 / Leukotriene B_4 / コラゲナ-ゼ阻害薬 / 内皮細胞粘着 / サブスタンスP / カプサイシン / 粘膜下微小循環 / 胃粘膜障害 / ロイコトリエンC4 / 血管内皮細胞粘着 / 好中球走化作用 / ロイコトリエンB4 / 好中球血管外游走 / ザフスタンスP / 心筋梗塞 / 5-リポキシゲナーゼ阻害薬 / カリクレイン / 胃粘膜傷害 / 接着分子 / 5-リポキシゲナーゼ / ロイコトリエンC_4 / ロイコトリエンB_4 / CGRPノックアウトマウス / 運動 / 粘膜血流 / 胃 / HUVEC / 軸索反射 / 神経ペプチド / がん性とう痛 / CGRPアゴニスト / VEGF / CD31 / 血管新生 / 後根神経節 / CGRP / 下肢虚血モデル Less

細胞外環境をセンスする知覚神経カルシトニン遺伝子関連ペプチドによる血管新生制御
- Principal Investigator
  
  馬嶋正隆
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Kitasato University
Roles of Calcitonin Gene-Related Peptide in Maintenance of Gastric Mucosal Integrity and in Enhancement of Ulcer Healing andAngiogenesisPrincipal Investigator
- Principal Investigator
  
  OHNO Takashi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kitasato University
Adaptive cytoprotection mediated by generated PGs (PGE_2 and/or PGI_2) through the release of CGRP.Principal Investigator
- Principal Investigator
  
  OHNO Takashi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KITASATO UNIVERSITY
内因性CGRPの胃粘膜保護作用に対するプロスタグランジンの役割-胃粘膜基底部微小循環観察法を用いて-Principal Investigator
- Principal Investigator
  
  大野隆
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kitasato University
胃粘膜保護作用における内因性ニューロペプチドとプロスタグランジンの相互作用Principal Investigator
- Principal Investigator
  
  大野隆
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kitasato University
生体顕微鏡による胃粘膜微小循環の観察とエンドセリンの作用Principal Investigator
- Principal Investigator
  
  大野隆
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kitasato University
Genetic background of development of hypertension and novel antipertensive drugs.
- Principal Investigator
  
  KATORI Makoto
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kitasato University
Interaction of leukotrienes with other mediators in pathological models and its regulation by drags.
- Principal Investigator
  
  KATORI Makoto
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kitasato University, School of Medicine

All 2010 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Roles of prostaglandin E2-EP1 receptor signaling in regulation of gastric motor activity and emptying.2010
- Author(s)
  Mizuguchi S, Ohno T, Hattori Y, Ae T, Minamino T, Satoh T, Arai K, Saeki T, Hayashi I, Sugimoto Y, Narumiya S, Saigenji K, Majima M.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol.
  
  Volume: 64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659037
[Journal Article] Roles of an inducible prostaglandin E synthase, mPGES-1 in the healing of acetic acid-induced gastric ulcer2009
- Author(s)
  T. Ae, T. Ohno, et al.
- Journal Title
  
  Journal of Pharmacological Sciences 109Supple. 1
  
  Pages: 212-212
- Data Source
  KAKENHI-PROJECT-18590699
[Journal Article] Roles of Calcitonin Gene-Related Peptide inMaintenance of Gastric Mucosal Integrityand in Enhancement of Ulcer Healing andAngiogenesis2008
- Author(s)
  T. Ohno, Y. Hattori, R. Komine, T. Ae, S. Mizuguchi, K. Arai, T. Saeki, T. Suzuki,K. Hosono, I. Hayashi, Y. Oh-hashi, Y.Kurihara, H. Kurihara, K. Amagase, S.Okabe, K. Saigenji, M. Majima
- Journal Title
  
  Gastroenterology 134
  
  Pages: 215-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590699
[Journal Article] Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis.2008
- Author(s)
  Ohno T, 他16名
- Journal Title
  
  Gastroenterology 134
  
  Pages: 215-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659037
[Journal Article] Roles of Calcitonin Gene-Related Peptide in Maintenance of Gastric Mucosal Integrity and in Enhancement of Ulcer Healing and Angiogenesis2008
- Author(s)
  Takashi Ohno. Youichiro Hattori, et. al.
- Journal Title
  
  Gastroenterology 134
  
  Pages: 215-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590699
[Journal Article] Gastric mucosal Protection against ethanol by EP_2 and EP_4 signaling through the inhibition of leukotriene C_4 Production2008
- Author(s)
  Youichiro Hattori, Takashi Ohno, et. al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590699
[Journal Article] Gastric mucosal protection against ethanol by EP2 and EP4 signaling throughthe inhibition of leukotriene C4production2008
- Author(s)
  Y. Hattori, T. Ohno, T. Ae, T. Saeki, K. Arai, S. Mizuguchi, K. Saigenji, M.Majima
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] 胃酢酸潰瘍治癒における誘導型プロスタグランディン合成酵素mPGES-1の役割2009
- Author(s)
  阿江太佳子, 大野隆, 他
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  パシフイコ横浜
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] Roles of an inducible prostaglandin E synthase, mPGES-1 in thehealing of acetic acid-induced gastriculcer2009
- Author(s)
  Takako Ae, Takashi Ohno, Youichiro Hattori, Katsunori Saigenji, MasatakaMajima
- Organizer
  The 13th Taishotoyama International Symposium onGastroenterology
- Place of Presentation
  Shimoda
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] Neuronal system-dependent facilitation ofangiogenesis during tumor development andulcer healing2009
- Author(s)
  大野隆, 馬嶋正隆
- Organizer
  第34回日本微小循環学会年次総会
- Place of Presentation
  東京・北里大学白金キャンパス
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] Roles of an inducible prostaglandin E synthase, mPGES-1 in thehealing of acetic acid-induced gastriculcer and angiogenesis2009
- Author(s)
  Takako Ae, Takashi Ohno, Youichiro Hattori, Katsunori Saigenji, MasatakaMajima
- Organizer
  DDW2009
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] Neuronal system-dependent facilitation of angiogenesis during tumor development and ulcer healing2009
- Author(s)
  大野隆, 馬嶋正隆
- Organizer
  第34回日本微小循環学会年次総会
- Place of Presentation
  東京・北里大学白金キャンパ
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] Role of an inducible prostaglandin E synthase, mPGES-1 in thehealing of acetic acid-induced gastriculcer2009
- Author(s)
  阿江太佳子, 大野隆, 服部庸一郎, 西元寺克禮, 馬嶋正隆
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] Neuronal system-dependent facilitation of angiogenesis during tumor development andulcer healing2009
- Author(s)
  Masataka Majima, Masaya Toda, Tatsunori Suzuki, Kanako Hosono, TakakoAe, Kento Nakatani, Takashi Ohno
- Organizer
  The 13th Taishotoyama International Symposium onGastroenterology
- Place of Presentation
  Shimoda
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] Gastric mucosal protection against ethanol by EP2 and EP4 signaling throughthe inhibition of leukotriene C4production2007
- Author(s)
  Y. Hattori, T. Ohno, T. Saeki, S. Mizuguchi, K. Arai, K. Saigenji, M. Majima
- Organizer
  The 12th Taishotoyama International Symposium onGastroenterology
- Place of Presentation
  Shimoda
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] Gastric mucosal protection through the inhibition of Leukotriene C4 production by an EP2 agonist and an EP4 agonist.2007
- Author(s)
  Y.Hattori, T.Ohno, T.Saeki, et. al.
- Organizer
  The 12th Taishotoyama International Symposium on Gastroenterology
- Place of Presentation
  Shimoda,Japan
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] Prostaglandin E2 protects gastric mucosal injury elicitedby ethanol through EP2 and EP4 signalingby reducing leukotriene C4 production2007
- Author(s)
  服部庸一郎, 大野隆, 新井勝春, 水口澄人, 西元寺克禮, 馬嶋正隆
- Organizer
  第32回日本微小循環学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] Gastric mucosal protection through the inhibition of Leukotriene C4 production by an EP2 agonist and an EP4 agonist2007
- Author(s)
  服部庸一郎, 大野隆, 新井勝春, 水口澄人, 佐伯威男, 西元寺克禮, 馬嶋正隆
- Organizer
  第80回日本薬理学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] Endogenous Calcitonin Gene-Related Peptide Exhibits Protective Action in Gastric Mucosal Injury and Facilitantes Ulcer Healing and Angiogenesis2007
- Author(s)
  T.Ohno, R.Komine, Y.Hattori, et. al.
- Organizer
  The 12th Taishotoyama International Symposium on Gastroenterology
- Place of Presentation
  Shimoda,Japan
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] エタノール胃粘膜障害に対するLTC4産生抑制を介したEP2およびEP4作動薬による保護作用2007
- Author(s)
  服部庸一郎, 大野隆, 佐伯威男, 水口澄人, 新井勝春, 西元寺克禮, 馬嶋正隆
- Organizer
  第93回日本消化器病学会総会
- Place of Presentation
  青森
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] Endogenous Calcitonin Gene-Related Peptide Exhibits Protective Action inGastric Mucosal Injury and FacilitantesUlcer Healing and Angiogenesis2007
- Author(s)
  T. Ohno, R. Komine, Y. Hattori, S. Mizuguchi, K. Arai, T. Saeki, T. Suzuki,K. Hosono, S. Okabe, K. Saigenji, M. Majima
- Organizer
  The 12th Taishotoyama International Symposium onGastroenterology
- Place of Presentation
  Shimoda
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] 胃粘膜保護作用を発揮するプロスタグランジンE2受容体の特定-胃粘膜微小循環観察法を用いた解析-2006
- Author(s)
  服部庸一郎, 大野隆, 佐伯威男, 水口澄人, 新井勝春, 西元寺克禮, 馬嶋正隆
- Organizer
  第92回日本消化器病学会総会
- Place of Presentation
  小倉
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] 胃粘膜保護作用を発揮するプロスタグランジンE2受容体の特定-ラット灌流モデルを用いた解析-2006
- Author(s)
  服部庸一郎, 大野隆, 佐伯威男, 水口澄人, 新井勝春, 西元寺克禮, 馬嶋正隆
- Organizer
  第48回日本消化器病学会大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-18590699
[Presentation] シンポジウムCGRPの胃粘膜恒常性維持と傷害修復における役割-胃粘膜微小循環の観点より-2006
- Author(s)
  大野隆, 馬嶋正隆
- Organizer
  潰瘍病態研究会第15回フォーラム
- Place of Presentation
  東京
- Year and Date
  2006-08-19
- Data Source
  KAKENHI-PROJECT-18590699

1. MAJIMA Masataka (70181641)

# of Collaborated Projects: 5 results

# of Collaborated Products: 17 results
2. HATANAKA Koh (00228470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KATORI Makoto (50050365)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KAWAMURA Michiko (00154104)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. HARADA Yoshiteru (20050677)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SAEKI Takao (20265614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
7. ARAI Katsuharu (50286259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
8. NISHIYAMA Kazuo (20180656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HAYASHI Hiromi (20238124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 鈴木立紀 (70406940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHNO Takashi 大野 隆

Research Projects

Research Products

Co-Researchers

細胞外環境をセンスする知覚神経カルシトニン遺伝子関連ペプチドによる血管新生制御

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of Calcitonin Gene-Related Peptide in Maintenance of Gastric Mucosal Integrity and in Enhancement of Ulcer Healing andAngiogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Adaptive cytoprotection mediated by generated PGs (PGE_2 and/or PGI_2) through the release of CGRP.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

内因性CGRPの胃粘膜保護作用に対するプロスタグランジンの役割-胃粘膜基底部微小循環観察法を用いて-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胃粘膜保護作用における内因性ニューロペプチドとプロスタグランジンの相互作用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

生体顕微鏡による胃粘膜微小循環の観察とエンドセリンの作用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic background of development of hypertension and novel antipertensive drugs.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interaction of leukotrienes with other mediators in pathological models and its regulation by drags.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Roles of prostaglandin E2-EP1 receptor signaling in regulation of gastric motor activity and emptying.2010

Author(s)

Journal Title

Data Source

[Journal Article] Roles of an inducible prostaglandin E synthase, mPGES-1 in the healing of acetic acid-induced gastric ulcer2009

Author(s)

Journal Title

Data Source

[Journal Article] Roles of Calcitonin Gene-Related Peptide inMaintenance of Gastric Mucosal Integrityand in Enhancement of Ulcer Healing andAngiogenesis2008

Author(s)

Journal Title

Data Source

[Journal Article] Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis.2008

Author(s)

Journal Title

Data Source

[Journal Article] Roles of Calcitonin Gene-Related Peptide in Maintenance of Gastric Mucosal Integrity and in Enhancement of Ulcer Healing and Angiogenesis2008

Author(s)

Journal Title

Data Source

[Journal Article] Gastric mucosal Protection against ethanol by EP_2 and EP_4 signaling through the inhibition of leukotriene C_4 Production2008

Author(s)

Journal Title

Data Source

[Journal Article] Gastric mucosal protection against ethanol by EP2 and EP4 signaling throughthe inhibition of leukotriene C4production2008

Author(s)

Journal Title

Data Source

OHNO Takashi 大野隆