OKUMURA Kazuhiko 奥村一彦

… Alternative Names

奥村一彦オクムラカズヒコ

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Researcher Number	60194510
External Links
Affiliation (Current)	2025: 北海道医療大学, 歯学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 北海道医療大学, 歯学部, 教授 2015 – 2016: 北海道医療大学, 歯学部, 准教授 2011 – 2014: 北海道医療大学, 歯学部, 講師 2002 – 2009: 北海道医療大学, 歯学部, 講師 1999 – 2000: 北海道医療大学, 歯学部, 講師 … More 1995 – 1997: 1st Dept.Oral & Maxillofacial Surg. Assist.Prof., 歯学部, 講師 1994 – 1995: 北海道医療大学, 歯学部・口腔外科学第一講座, 講師 1988 – 1992: 東日本学園大学, 歯学部, 助手 Less
Review Section/Research Field	Principal Investigator Surgical dentistry / Surgical dentistry / Basic Section 57060:Surgical dentistry-related Except Principal Investigator Veterinary medical science / Basic Section 57060:Surgical dentistry-related / Functional basic dentistry / Pathobiological dentistry/Dental radiology / 外科・放射線系歯学 / Surgical dentistry
Keywords	Principal Investigator 口腔扁平上皮癌細胞 / 抗腫瘍効果 / 自然免疫 / 抗菌ペプチド / ADAR1 / FAK / 獲得免疫 / 細胞遊走能 / 抗菌効果 / 樹状細胞 … More / アポトーシス / 口腔扁平上皮癌 / LL-37 / hCAP18 / 自然免疫分子 / 幹細胞マーカー / ヒト口腔癌癌細胞株 / RNA編集酵素 / 上皮ー間葉転換 / スフェロイド形成細胞 / 上皮ー間葉転換誘導 / RNA編集酵素ADAR1 / スフェロイド形成 / 癌幹細胞 / 癌細胞浸潤能 / ADAR2 / 基底膜浸潤能 / 細胞増殖活性 / 造腫瘍活性 / レンチウイルスベクター / ADAR1遺伝子 / 癌の悪性化進展 / FNLB / RNA編集異常 / FLNB / AZIN1 / エピジェネティク / Antitumor effect / Anitimicrobial effect / Cathelicidin family / Antimicrobial peptides / Dendritic cells / Acquired immunity / Innate immunity / 核の断片化 / Endonuclease G / Cathericidin family / 獲得免疫医 / カテリシジンファミリー / Molecular targeted therapy / in vivo metastatic mouse / Cervical neck lymph node metastasis / GFP transfected oral cancer cells / 血中循環癌細胞 / 低浸潤性癌細胞 / 高浸潤性癌細胞 / 浸潤転移機構 / 分子標的薬 / in vivo転移マウス / 頸部リンパ節転移 / GFP導入口腔癌細胞 / Oral Squamous Cell Carcinoma Cells / Differential Display PCR / Metastasis Related Genes / Invasion / 口腔偏平上皮癌細胞 / DD法 / 浸潤転移関連遺伝子 / Rho family / Cell mitility / Cell adhesiveness / tyrosine phosphorylation / PI3-kinase / metastasis / invasion / human OSCC cells / Focal adhesion kinase / PI3-Kinase / 浸潤・転移 / Rhoファミリー / 運動性 / 接着性 / チロシンリン酸化 / PI3キナーゼ / 浸潤転移 / ヒト口腔扁平上皮癌細胞 / rho proteins / secretory granule membranes / Parotid / low mr GTP binding proteins / exocytosis / 低分子量GTP結合蛋白質 / rho蛋白 / 分泌顆粒膜 / 耳下腺 / 低分子量GTP結合蛋白 / 開口分泌 / 上皮間葉移行関連分子 / 腫瘍抑制 / MMP-9 / 浸潤性 / miRNA制御 / 血管新生制御機構 / ヒトカセリシジン / カセリシジン / カテリシジンファミリー / 癌抑制遺伝子 / 基質分解酵素 / 細胞浸潤能 / 抗腫瘍活性 / ネクローシス / 口腔感染症 / カセリシジン・ファミリー … More Except Principal Investigator 多剤耐性菌 / miRNA / 抗癌活性 / 抗菌活性 / 自然免疫 / 抗菌ペプチド / osteoprotegerin / candida albicans / Candida albicans / RANK / RANKL / Osteoprotegerin / 多機能性 / 癌細胞 / 病原微生物 / 細菌 / 癌 / エクソソーム / Calmodulin Antagonists / Calcium / Calcium Chelator / Exocytosis / Amylase Secretion / Calmodulin / Salivary Glands / Parotid Glands / サイクリックAMP / アミラーゼ分泌 / カルシウム・キレ-ト剤 / カルモジュリン阻害薬 / 開口分泌 / カルシウムキレ-ト剤 / カルシウム / アミラ-ゼ分泌 / カルモジュリン / 唾液腺 / 耳下腺 / Lymphoma / Squamous cell carcinoma / DNA vaccine / Gene therapy / Antitumor / Beta-defensin / CCR6 / 遺伝子導入 / 樹状細胞 / リンパ腫 / 扁平上皮癌 / DNAワクチン / 遺伝子治療 / 抗腫瘍性 / βディフェンシン / Histological findings / Hypermobility / Rat / Temporomandibular joint / 過運動(Hypermbility) / 組織学的変化 / Hypermobility(過剰運動) / ラット顎関節 / 病理組織像 / 過剰運動 / ラット / 顎関節 / 疾病予防 / 抗癌 / 抗菌 / カセリシジン / 分子改変 / 抗腫瘍活性 / 分子標的 / アポトーシス / メタボローム解析 / 腫瘍 / 薬剤耐性菌 / 細胞接着性 / 細胞分化療法 / RNAi / 細胞間接着分子 / 細胞直接性 / 基底膜浸潤能 / 癌細胞遊走能 / MMP-9高発現クローン / MMP-9高産生癌細胞 Less

Targeting therapy of oral cancer stem cell renewal by RNA editing enzymePrincipal Investigator
- Principal Investigator
  
  Okumura Kazuhiko
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Health Sciences University of Hokkaido
RANK/RANKL/OPG signaling upregulates IL-10 -regulated anti-inflammatory response during Candida albicans Infection
- Principal Investigator
  
  Kobayashi Michiyo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Ohu University
多機能性抗菌ペプチドの統合的解明と疾病制御
- Principal Investigator
  
  磯貝恵美子
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Tohoku University
Altered RNA editing and malignant progression in oral squamous carcinoma.Principal Investigator
- Principal Investigator
  
  Okumura Kazuhiko
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Health Sciences University of Hokkaido
Taget molecule of antimicrobial peptides and disease control
- Principal Investigator
  
  Isogai Emiko
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Tohoku University
Study of miRNA regulatory systems of antitumor effects by human cathelicidin.Principal Investigator
- Principal Investigator
  
  OKUMURA Kazuhiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Health Sciences University of Hokkaido
Development of new therapy of oral infection and cancer by applying innate immunity network.Principal Investigator
- Principal Investigator
  
  OKUMURA Kazuhiko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Health Sciences University of Hokkaido
Study of antitumor effect and dendritic cells induced by human Cathelicidin hCAP18.Principal Investigator
- Principal Investigator
  
  OKUMURA Kazuhiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Health Sciences University of Hokkaido
MMP-9/RNAiによる癌の浸潤転移抑制と細胞分化療法の開発
- Principal Investigator
  
  柴田考典
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Health Sciences University of Hokkaido
Antitumor effect of gene transfection and DNA vacccine of beta-defensins
- Principal Investigator
  
  ABIKO Yoshihiro
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Health Sciences University of Hokkaido
Study of suppressions of invasion / metastasis by molecular targeted therapy using GFP exppessing transfectant of a high-invasion human tongue squamous cell carcinoma cells, SAS-H1.Principal Investigator
- Principal Investigator
  
  OKUMURA Kazuhiko
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Health Sciences University of Hokkaido
Search for Invasion/Metastasis Related Genes of Oral Squamous Cell Carcinoma using Differential DisplayPrincipal Investigator
- Principal Investigator
  
  OKUMURA Kazuhiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Health Sciences University of Hokkaido
Study of signal transduction of invasion / metastasis via PI3-kinase in the oral squamous cell carcinoma.Principal Investigator
- Principal Investigator
  
  OKUMURA Kazuhiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Health Sciences University of Hokkaido
Study of the low molecular weight GTP binding proteins in amylase exocytosis of parotid acini in vitro.Principal Investigator
- Principal Investigator
  
  OKUMURA Kazuhiko
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Health Sciences University of Hokkaido
Tissue reactions in the rat TMJ resulting from hypermobility of the mandible
- Principal Investigator
  
  MUTO Toshitaka
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  Higashi-Nippon-Gakuen University
The Physiological Role of Calmodulin in Rat Parotid Amylase Release
- Principal Investigator
  
  TOJYO Yosuke
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Higashi-Nippon-Gakuen University, School of Dentistry

[Journal Article] DNA-PKcs phosphorylation specific inhibitor, NU7441, enhances the radiosensitivity of clinically relevant radioresistant oral squamous cell carcinoma cells2023
- Author(s)
  Ohuchi Kentaro、Saga Ryo、Hasegawa Kazuki、Tsuruga Eichi、Hosokawa Yoichiro、Fukumoto Manabu、Okumura Kazuhiko
- Journal Title
  
  Biomedical Reports
  
  Volume: 18 Issue: 4 Pages: 1-8
- DOI
  10.3892/br.2023.1610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10342
[Journal Article] Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability2022
- Author(s)
  Fukui Roman、Saga Ryo、Matsuya Yusuke、Tomita Kazuo、Kuwahara Yoshikazu、Ohuchi Kentaro、Sato Tomoaki、Okumura Kazuhiko、Date Hiroyuki、Fukumoto Manabu、Hosokawa Yoichiro
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 1056-1056
- DOI
  10.1038/s41598-022-05172-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12326, KAKENHI-PROJECT-19K17215, KAKENHI-PROJECT-19K08141, KAKENHI-PROJECT-19K10342, KAKENHI-PROJECT-20K16814, KAKENHI-PROJECT-20K12173
[Journal Article] 放射線治療に関わる癌幹細胞2019
- Author(s)
  細川陽一郎、嵯峨　涼、長谷川和輝、大内健太郎、奥村一彦
- Journal Title
  
  保健科学研究
  
  Volume: 10 Pages: 1-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10342
[Journal Article] Regulation of radiosensitivity by 4-methylumbelliferone via the suppression of interleukin-1 in fibrosarcoma.2019
- Author(s)
  Saga, R., Hasegawa, K., Murata, K., Chuiba, M., Nakamura, T., Okumura, K., Tsuruga, E., Hosokawa, Y.
- Journal Title
  
  Oncology Letters
  
  Volume: 17 Pages: 3555-3561
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10342
[Journal Article] Regulation of radiosensitivity by 4-methylumbelliferone via the suppression of interleukin-1 in fibrosarcoma cells2019
- Author(s)
  Saga R, Hasegawa K, Murata K, Chiba M, Nakamura T, Okumura K, Tsuruga E, Hosokawa Y.
- Journal Title
  
  Oncology Letters
  
  Volume: 17 Pages: 3555-3561
- DOI
  10.3892/ol.2019.9990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11068, KAKENHI-PROJECT-17K16413, KAKENHI-PROJECT-15K11265
[Journal Article] miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway2017
- Author(s)
  Kuroda K, Fukuda T, Krstic-Demonacos M, Demonacos C, Okumura K, Isogai H, Hayashi M, Saito K, Isogai E
- Journal Title
  
  BMC Cancer
  
  Volume: Jan 7;17(1):33 Issue: 1 Pages: 33-33
- DOI
  10.1186/s12885-016-3003-9
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-14J05415, KAKENHI-PROJECT-25292178, KAKENHI-PROJECT-15K11265, KAKENHI-PROJECT-16H05036
[Journal Article] The human cathelicidin antimicrobial peptide LL-37 and mimics are potential anticancer drugs.2015
- Author(s)
  Kuroda, K., OKumura, K., Isogai, H., Isogai, E.
- Journal Title
  
  Front Oncol
  
  Volume: 5 Pages: 1-10
- DOI
  10.3389/fonc.2015.00144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11265, KAKENHI-PROJECT-14J05415
[Journal Article] Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile2015
- Author(s)
  Kuroda K, Fukuda T, Isogai H, Kazuhiko Okumura, Krstic-Demonacos M, Isogai E
- Journal Title
  
  Int J Oncol.
  
  Volume: 46(4) Issue: 4 Pages: 1516-1526
- DOI
  10.3892/ijo.2015.2887
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J05415, KAKENHI-PROJECT-25292178
[Journal Article] Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells2013
- Author(s)
  Kuroda K, Fukuda T, Okumura K, Yoneyama H, Isogai H, Savage PB, Isogai E
- Journal Title
  
  Anti-Cancer Drugs
  
  Volume: 24 Pages: 826-834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592938
[Journal Article] Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells2013
- Author(s)
  Kuroda K., Fukuda T., Okumura K., Yoneyama H., Isogai H., Savage P.B., Isogai E.
- Journal Title
  
  Anti Cancer Drags
  
  Volume: 23 Issue: 8 Pages: 826-834
- DOI
  10.1097/cad.0b013e3283634dd0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590397, KAKENHI-PROJECT-23592938
[Journal Article] Anti-proliferative effect of the analogue peptide of human Cathelicidin (hCAP18/LL-37) for the colon cancer derived cell line, HCT116 p53+/+ and p53-/-.2012
- Author(s)
  Kuroda K, Fukuda T, Yoneyama H, Katayama M, Isogai H, Okumura K, and Isogai E
- Journal Title
  
  Oncology Reports In press
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592938
[Journal Article] Anti-proliferative effect of the analogue peptide of human Cathelicidin (hCAP18/LL-37) for the colon cancer derived cell line, HCT116 p53+/+ and p53-/-2012
- Author(s)
  Kuroda K, Fukuda T, Yoneyama H, Katayama M, Isogai H, Okumura K, and Isogai E
- Journal Title
  
  Oncology Reports
  
  Volume: 28 Issue: 3 Pages: 829-834
- DOI
  10.3892/or.2012.1876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590397, KAKENHI-PROJECT-23592938
[Journal Article] Biofilm formation by streptococcus mutans and related bacteria.2012
- Author(s)
  Nishimura J, Saito T, Yoneyama H, Bai L L, Okumura K,Isogai E.
- Journal Title
  
  Advances in Microbiology
  
  Volume: 2 Issue: 03 Pages: 208-215
- DOI
  10.4236/aim.2012.23025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592938
[Journal Article] 磯貝恵美子、秋葉敬斎、岡翔太、堀初弘、磯貝浩、小林美智代、奥村一彦2011
- Author(s)
  磯貝恵美子、秋葉敬斎、岡翔太、堀初弘、磯貝浩、小林美智代、奥村一彦
- Journal Title
  
  マダニデフェンシンの中腸由来細菌に対する抗菌活性、無菌生物
  
  Volume: 41 Pages: 113-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592938
[Journal Article] マダニデフェンシンの中腸由来細菌に対する抗菌活性2011
- Author(s)
  磯貝恵美子、秋葉敬斎、岡　翔太、堀　初弘、磯貝　浩、小林美智代、奥村一彦
- Journal Title
  
  無菌生物
  
  Volume: 41 Pages: 113-116
- NAID
  10029976308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592938
[Journal Article] Cathelicidins-therapeutic antimicrobial and antitumor host defense peptides for oral diseases.2010
- Author(s)
  Okumura, K.
- Journal Title
  
  J. Dent. Res. Science (In press)
- NAID
  10027850259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592309
[Journal Article] Cathelicidins-therapeutic antimicrobial and antitumor host defense peptides for oral diseases.2010
- Author(s)
  Okumura, K
- Journal Title
  
  J.Dent.Res.Science. (In press)
- NAID
  10027850259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592309
[Journal Article] Antimicrobial activity of three tick defensing and four mammalian cathlicidin-derived synthetic peptides against Lyme disease spirochetes and bacteria isolated from the midgut.2009
- Author(s)
  Isogai, E., Isogai, H., Takahashi, K., Kobayashi-Sakamoto, M., Okumura, K
- Journal Title
  
  Exp.Appl.Acrol. 49
  
  Pages: 221-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592309
[Journal Article] Ceragenin CSA-13 exhibits antimicrobial activity against cario genie and periodontopathic bacteria2009
- Author(s)
  Isogai, E., Isogai, H., Takahashi, K., Okumura, K., Savege P B
- Journal Title
  
  Oral Microbiol Immunol 24
  
  Pages: 170-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592309
[Journal Article] Antimicrobial activity of three tick defensins and four mammalian cathlicidin-derived synthetic peptides against Lyme disease spirochetes and bacteria isolated from the midgut2009
- Author(s)
  Isogai, E., Isogai, H., Takahashi, K., Kobayashi-Sakamoto, M., Okumura, K.
- Journal Title
  
  Exp. Appl. Acrol. 49
  
  Pages: 221-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592309
[Journal Article] Ceragenin CSA-13 exhibits antimicrobial activity against cariogenic and periodontopathic bacteria2009
- Author(s)
  Isogai E, Isogai H, Takahashi K, Okumura K, Savage P B
- Journal Title
  
  Oral Microbiol Immunol 24
  
  Pages: 170-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592309
[Journal Article] Ceragenin CSA-13 exhibits antimicrobial activity against cariogenic and periodontopathic bacteria.2008
- Author(s)
  Isogai E, Isogai H, Takahashi K, Okumura K. Savage PB.
- Journal Title
  
  Oral Microbiol Immunol (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592309
[Journal Article] Survival strategy of lactic acid bacteria through bacterial component and its induced factors.2006
- Author(s)
  Isogai, H., Isogai, E., Okumura, K., Hirose, K.
- Journal Title
  
  Jpn. J. Lactic Acid Bact. 17
  
  Pages: 40-46
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17592098
[Journal Article] 乳酸菌の菌体成分および誘導物質による生き残り戦略2006
- Author(s)
  磯貝浩, 磯貝恵美子, 奥村一彦, 広瀬公治
- Journal Title
  
  Jpn. J. Lactic Acid Bact. 17
  
  Pages: 40-46
- NAID
  10029751156
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17592098
[Journal Article] Tumor Growth, Invasion, Micrometastasis, and Lymph Node Metastasis of Oral Squamous Cell Carcinoma Visualized in Live Tissue by Green Fluorescent Protein Expression2005
- Author(s)
  A.Itoh, K.Okumura, Y.Abiko, et al.
- Journal Title
  
  Oral Science International 2(1)(in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571906
[Journal Article] Tumor Growth, Invasion, Micrometastasis, and Lymph Node Metastasis of Oral Squamous Cell Carcinoma Visualized in Live Tissue by Green Fluorescent Protein Expression2005
- Author(s)
  Itoh, A., Okumura, K.et al.
- Journal Title
  
  Oral Science International 2.1
  
  Pages: 45-53
- Data Source
  KAKENHI-PROJECT-17592098
[Journal Article] Tumor growth, local invasion, micrometastasis lymph node metastasis of oral squamous cell carcinoma visualized in live tissue by green expession2005
- Author(s)
  Akifumi Ito, Kazuhiko Okumura, Takanori Shibata et al.
- Journal Title
  
  Oral Science International Vol.2 (In press)
- Data Source
  KAKENHI-PROJECT-16659560
[Journal Article] Tumor Growth, Invasion, Micrometastasis, and Lymph Node Metastasis of Oral Squamous Cell Carcinoma Visualized in Live Tissue by Green Fluorescent Protein Expression.2005
- Author(s)
  A.Itoh, K.Okumura, Y.Abiko, et al.
- Journal Title
  
  Oral Science International 2(1)(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571906
[Journal Article] Tumor growth, local invasion, micrometastasis lymph node metastasis of oral squamous cell carcinoma visualized in live tissue by green protein expession2005
- Author(s)
  Akifumi Ito, Kazuhiko Okumura, Takanori Shibata et al.
- Journal Title
  
  Oral Science International Vol.2
  
  Pages: 45-53
- Data Source
  KAKENHI-PROJECT-16659560
[Journal Article] C-terminal domain of human CAP18 antimicrobial peptide induces apoptosis in oral squamous cell carcinomaSAS-H1cells.2004
- Author(s)
  K.Okumura, A.Itoh, E.Isogai, et al.
- Journal Title
  
  Cancer Letters 212
  
  Pages: 185-194
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571906
[Journal Article] C-terminal domain of human CAP 18 antimicrobial peptide induces apoptosis in oral squamous cell carcinomaSAS-H1cells.2004
- Author(s)
  K.Okumura, A.Itoh, E.Isogai, et al.
- Journal Title
  
  Cancer Letters 212
  
  Pages: 185-194
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571906
[Journal Article] C-terminal domain of human CAP18 antimicrobial peptide induces apotosis in oral squamous cell2004
- Author(s)
  Okumura, K., Itoh, A., Isogai, E., Hirose, K., Hosokawa, Y., Abiko, Y., Shibata, T., Hirata, M., Isogai, H
- Journal Title
  
  Cancer Lett 212
  
  Pages: 185-94
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591894
[Journal Article] C-terminal domain of human CAP18 antimicrobial peptide induces apotosis in oral squamous cell2004
- Author(s)
  Okumura K, Itoh A, Isogai E, Hirose K, Hosokawa Y, Abiko Y, Shibata T, Hirata M, Isogai H
- Journal Title
  
  Cancer Lett 212
  
  Pages: 185-194
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16591894
[Journal Article] C-terminal domain of human CAP18 antimicrobial peptide induces apoptosis in oral squamous cell carcinomaSAS-H1cells.2004
- Author(s)
  K.Okumura, A.Itoh, E.Isogai.et al.
- Journal Title
  
  Cancer Letters 212
  
  Pages: 185-194
- Data Source
  KAKENHI-PROJECT-14571906
[Presentation] 放射線抵抗性を獲得した口腔扁平上皮癌細胞における放射線応答変化2021
- Author(s)
  大内健太郎、細川洋一郎、奥村一彦
- Organizer
  北海道医療大学歯学会第39回学術大会、2021年3月13日、オンライン開催
- Data Source
  KAKENHI-PROJECT-19K10342
[Presentation] The analogue human cathelicidin antimicrobial peptide is a potential anticancer drug2016
- Author(s)
  Kuroda K, Fukuda T, Isogai H, Okumura K, Krstic-Demonacos M, Isogai E
- Organizer
  21th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine
- Place of Presentation
  Ｇｒｅｅｃｅ，Athens, Metropolitan Hotel
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05036
[Presentation] The analogue human cathelicidin antimicrobial peptide is a potential anticancer drug2016
- Author(s)
  Kuroda K, Fukuda T, Isogai H, Okumura K, Krstic-Demonacos M, Isogai E
- Organizer
  21th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine
- Place of Presentation
  Greece, Athens, Metropolitan Hotel
- Year and Date
  2016-10-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292178
[Presentation] MicroRNA array analysis in colon cancer cells treated with antimicrobial peptides2015
- Author(s)
  Kuroda　K, Fukuda T, Isogai H, Okumura K, Isogai E
- Organizer
  20th World Congress on Advances in Oncology and 17th International Symposium on Molecular Medicine
- Place of Presentation
  Metropolitan Hotel, Athne, Greece
- Year and Date
  2015-10-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292178
[Presentation] 大腸菌に発現させた抗菌タンパクとその活性2014
- Author(s)
  磯貝浩，磯貝恵美子，黒田健吾，奥村一彦
- Organizer
  第87回日本細菌学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25292178
[Presentation] 大腸菌に発現させた抗菌タンパクとその活性2014
- Author(s)
  磯貝浩、磯貝恵美子、黒田健吾、奥村一彦
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京都、タワーホール船堀(江戸川区総合区民ホール)
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] 大腸菌に発現させた抗菌タンパクとその活性2014
- Author(s)
  磯貝浩、磯貝恵美子、黒田健吾、奥村一彦
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京都　タワーホール船堀（江戸川区総合区民ホール）
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] カセリシジンは口腔扁平上皮癌細胞のMatrix Metalloprotease-9発現の陰性制御を行う2014
- Author(s)
  奥村一彦、磯貝恵美子、柴田考典、磯貝　浩
- Organizer
  第87回日本細菌学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25292178
[Presentation] Cathelicidin negatively regulates Matrix Metalloprotinase-9 expression in human tumor cell lines.2014
- Author(s)
  Okumura, K., Isogai, E., Shibata, T., Isogai, H.
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京都　タワーホール船堀（江戸川区総合区民ホール）
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] Cathelicidin negatively regulates Matrix Metalloprotinase-9 expression in human tumor cell lines2014
- Author(s)
  Okumura, K., Isogai, E., Shibata, T., Isogai, H
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京都、タワーホール船堀(江戸川区総合区民ホール)
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] 624 Cathelicidin is a regulator of invasion in oral squamous-cell carcinoma2013
- Author(s)
  Okumura, K., Sawada, N., Isogai, E., Shibata, T. Isogai, H
- Organizer
  The 2nd Meeting of the International Association of Dental Research-Asia Pacific Region (IADR-APR)
- Place of Presentation
  Thailand, Bangkok,Plaza Athenee
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] Antimicrobial cationic steroid and a cathelicidin-derived peptide have anti-proliferative effects to colon cancer cell line2013
- Author(s)
  Kuroda K, Fukuda T, Okumura K, Yoneyama H, Isogai H, Savage PB, Isogai E.
- Organizer
  ASM 2013 General Meeting
- Place of Presentation
  Denver, Colorado, US
- Data Source
  KAKENHI-PROJECT-25292178
[Presentation] 抗菌ペプチドhCAP18の細胞膜穴形成を介した細胞死2013
- Author(s)
  奥村一彦、柴田考典
- Organizer
  第58回(公社)日本口腔外科学会総会・学術大会
- Place of Presentation
  福岡県、福岡国際会議場、マリンメッセ
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] Suppressive effects of cationic antimicrobial peptides and mimics on colon cancer cell line HCT116 p53+/+ and p53-/-2013
- Author(s)
  Kuroda K, Fukuda T, Yoneyama H, Okumura K, Isogai H, Savage PB, Isogai E.
- Organizer
  18th World Congress on Advances in Oncology and 16th International Symposium on Molecular Medicine
- Place of Presentation
  Crete, Greece
- Data Source
  KAKENHI-PROJECT-25292178
[Presentation] 小児でみられた頬粘膜色素性母斑の一例2013
- Author(s)
  奥村一彦、村田幸枝，辻　祥之、倉重圭史広、広瀬弥奈、五十嵐清治
- Organizer
  第25回日本小児口腔外科学会総会・学術大会
- Place of Presentation
  東京都　タワーホール船堀（江戸川区総合区民ホール）
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] Cathelicidin is a regulator of invasion in oral squamous-cell carcinoma.2013
- Author(s)
  Okumura, K., Sawada, N., Isogai, E., Shibata, T. Isogai, H.
- Organizer
  The 2nd Meeting of the International Association of Dental Research-Asia Pacific Region (IADR-APR)
- Place of Presentation
  Thailand, Bangkok, Plaza Athenee,
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] 抗菌ペプチドhCAP18の細胞膜穴形成を介した細胞死2013
- Author(s)
  奥村一彦、柴田考典
- Organizer
  第58回(公社)日本口腔外科学会総会・学術大会
- Place of Presentation
  福岡県　福岡国際会議場、マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] 抗菌ペプチド遺伝子導入扁平上皮癌細胞の基底膜浸潤抑制2012
- Author(s)
  奥村一彦、平　博彦、柴田考典
- Organizer
  第57回(公社)日本口腔外科学会総会・学術大会
- Place of Presentation
  パシフィコ横浜　会議センター
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] 抗菌ペプチド遺伝子導入扁平上皮癌細胞の基底膜浸潤抑制2012
- Author(s)
  奥村一彦、平博彦、柴田考典
- Organizer
  第57回(公社)日本口腔外科学会総会・学術大会
- Place of Presentation
  神奈川県、パシフィコ横浜会議センター
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] Cathelicidin antimicrobial peptide, LL-37 has proangiogenic and angiostatic activity in human microvascular endothelial cells.2011
- Author(s)
  Okumura K, Kobayashi-Sakamoto M, Taira H, Isogai E, Isogai H.
- Organizer
  International Union of Microbiological Societies (IUMS) 2011 Congress　XIII International Congress of Bacteriology and Applied Microbiology
- Place of Presentation
  Sapporo convention center, Hokkaido, Japan.
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] Thrombin induces osteopritegrin production via phosphatidylinositol 3-kinase pathway in human microvascular endothelial cells.2011
- Author(s)
  Kobayashi-Sakamoto M, Isogai E, Hirose K, Okumura K, Holen I, Chiba I.
- Organizer
  10th World Congress on Inflammation
- Place of Presentation
  Palais des Congres, Paris, France
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] トロンビンは血管内皮細胞においてオステオプロテゲリンの産生を誘導する2011
- Author(s)
  小林美智代、磯貝恵美子、廣瀬公治、奥村一彦、千葉逸朗
- Organizer
  第32回日本炎症・再生医学会
- Place of Presentation
  国立京都国際会館、京都
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] Thrombin induces osteopritegrin production via phosphatidylinositol 3-kinase pathway in human microvascular endothelial cells2011
- Author(s)
  Kobayashi-Sakamoto M, Isogai E, Hirose K, Okumura K, Holen I, Chiba I
- Organizer
  10th World Congress on Inflammation
- Place of Presentation
  Palais des Congres, Paris, France
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] LL-37 induces angiostatic activity through FPRL1 in microvascular endothelial cells.2011
- Author(s)
  Okumura K, Sawada T, Kobayashi-Sakamoto M, Taira H, Isogai E, Isogai H.
- Organizer
  45th Meeting of the Continental European Division (CED) of IADR
- Place of Presentation
  Semmelweis University Theoretical Building, Budapest, Hungary
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] LL-37は血管形成制御を担う抗菌ペプチドである2011
- Author(s)
  奥村一彦、平　博彦、柴田考典
- Organizer
  第56回(社)日本口腔外科学会総会・学術大会
- Place of Presentation
  大阪国際会議場、大阪
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] ヒト由来抗菌蛋白質hCAP18/LL-37導入癌細胞の浸潤転移形質の低下2009
- Author(s)
  奥村一彦, 平博彦, 磯貝恵美子, 磯貝浩
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] ヒト抗菌ペプチドhCAP18/LL-37は、上皮間葉移行を介し細胞遊走を制御する2009
- Author(s)
  奥村一彦、平慱彦、柴田考典
- Organizer
  第54回(社)日本口腔外科学会総会・学術大会
- Place of Presentation
  札幌ユンベンションセンー(北海道)
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] Tumor suppression by hCAP18 in oral squamous cell carcinoma cells.2009
- Author(s)
  Okumura, K., Sawada, N., Taira, H., Isogai, E., Shibata, T., Isogai, H.
- Organizer
  IADR-Continental European Division (CED),
- Place of Presentation
  Gasteig Convention Centre, Munich, Germany.
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] Tumor suppression by hCAP18 in oral squamous cell carcinoma cells.2009
- Author(s)
  Okumura, K., Sawada, N., Taira, H., Isogai, E., Shibata, T., Isogai, H.
- Organizer
  IADR-Continental European Division (CED)
- Place of Presentation
  Gasteig Convention Centre, Munich, Germany
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] ヒト抗菌ペプチドhCAP18/LL-37は、上皮間葉移行を介し細胞遊走を制御する2009
- Author(s)
  奥村一彦、平博彦、柴田考典
- Organizer
  第54回(社)日本口腔外科学会総会・学術大会
- Place of Presentation
  札幌コンベンションセンター(札幌)
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] Antimicrobial activity of tick defensins against Lyme disease spirochetes and bacteria isolated from the midgut.2008
- Author(s)
  Isogai, H, Isogai, E, Takahashi, K, Kobayashi-Sakamoto, M, Okumura, K
- Organizer
  11th International conference Lyme borreliosis & other tick-borne diseases
- Place of Presentation
  Irvine, California, USA
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] Antimicrobial activity of tick defensins against Lyme disease spirochetes and bacteria isolated from the midgut.2008
- Author(s)
  Isogai, H., Isogai, E., Takahashi, K., Kobayashi-Sakamoto, M., Okumura, K
- Organizer
  11^<th> International conference Lyme borrelios is & other tick-borne diseases
- Place of Presentation
  Irvine, California, USA
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] 癌細胞が発現するケモカイン受容体CX3CR1を介した局所浸潤機構の解析-癌原発巣周囲の血管内皮細胞の関与-2008
- Author(s)
  奥村一彦, 村岡勝美, 河東秀貴, 細川洋一郎, 磯貝恵美子, 田中真樹, 有末眞, 柴田考典
- Organizer
  第62回NPO法人日本口腔科学会学術集会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] Expression of hCAP18 is resistant factor against hCAP18-induces apoptosis2007
- Author(s)
  Okumura, K. Sawada, N, Muraoka, K. Kato, H, Isogai, E, Hosokawa, Y, Shibata, T, Isogai, H.
- Organizer
  42nd Annual Meeting IADR/CED-ID
- Place of Presentation
  Thessaloniki, Greece
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] 炎症性サイトカイン,増殖因子は,癌細胞のケモカイン受容体発現を増強し浸潤性を促進する.2007
- Author(s)
  河東秀貴, 奥村一彦, 村岡勝美, 有末眞
- Organizer
  第61回NPO法人日本口腔科学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] 高浸潤性舌扁平上皮癌細胞のFractakineによる浸潤促進機構の解析2007
- Author(s)
  村岡勝美, 奥村一彦, 北所弘行, 河東秀貴, 永易裕樹.有末眞
- Organizer
  第61回NPO法人日本口腔科学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] ヒト好中球由来hCAPI8/LL-37遺伝子導入細胞による抗菌ペプチド産生と抗菌抗癌効果.2007
- Author(s)
  奥村一彦, 平博彦, 村岡勝美, 河東秀貴, 柴田考典
- Organizer
  第61回NPO法人日本口腔科学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] 高浸潤性舌扁平上皮癌細胞のFractakineによる浸潤促進機構の解析.2007
- Author(s)
  村岡勝美, 奥村一彦, 北所弘行, 河東秀貴, 永易裕樹, 有末眞
- Organizer
  第61回NPO法人日本口腔科学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] Expression of hCAP18 is resistant factor against hCCAPl8-induces apoptosis.2007
- Author(s)
  K.Okumura, N, Sawada, K.Muraoka, H.Kato, E.Isogai, Y.Hosokawa, T.Shibata, H.Isogai
- Organizer
  42^<nd> Annual Meeting IADR/CED-ID
- Place of Presentation
  Thessaloniki, Greece
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] 炎症性サイトカイン, 増殖因子は, 癌細胞のケモカイン受容体発現を増強し浸潤性を促進する2007
- Author(s)
  河東秀貴, 奥村一彦, 村岡勝美, 有末眞
- Organizer
  第61回NPO法人日本口腔科学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-19592309
[Presentation] Elucidation of metabolic pathways for the colon cancer cell line HCT116 treated with antimicrobial peptide FF/CAP18
- Author(s)
  Kuroda K, Fukuda T, Isogai H, Okumura K, Isogai E
- Organizer
  14th International Symposium on Antimicrobial Peptides
- Place of Presentation
  Lorient, France
- Year and Date
  2014-06-04 – 2014-06-06
- Data Source
  KAKENHI-PROJECT-25292178
[Presentation] Metabolites variation in colon cancer cell line HCT116 treated with antimicrobial peptide FF/CAP18
- Author(s)
  Kuroda K, Fukuda T, Isogai H, Okumura K, Isogai E
- Organizer
  19th World Congress on Advances in Oncology and 17th International Symposium on Molecular Medicine
- Place of Presentation
  Athenes, Greece
- Year and Date
  2014-10-09 – 2014-10-11
- Data Source
  KAKENHI-PROJECT-25292178

1. ISOGAI Emiko (80113570)

# of Collaborated Projects: 5 results

# of Collaborated Products: 27 results
2. TOMIOKA Keiko (10227613)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KOBAYASHI Michiyo (80316265)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
4. ABIKO Yoshihiro (90260819)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. ARAKAWA Toshiya (40306254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 福田智一 (40321640)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
7. MUTO Toshitaka (00143298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MICHIYA Hiroyuki (20166052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KONISHI Atsushi (80225466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAKU Tohru (60133253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAGAYASU Hiroki (90265075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TOJYO Yosuke (90111731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TANIMURA Akihiko (70217149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 柴田考典 (60147220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 細川洋一郎 (70173599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
16. 坂本直哉 (30466429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ISOGAI Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 佐藤友昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 桑原義和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 富田和男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 中村敏也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKUMURA Kazuhiko 奥村 一彦

奥村 一彦 オクムラ カズヒコ

Research Projects

Research Products

Co-Researchers

Targeting therapy of oral cancer stem cell renewal by RNA editing enzymePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RANK/RANKL/OPG signaling upregulates IL-10 -regulated anti-inflammatory response during Candida albicans Infection

Principal Investigator

Project Period (FY)

Research Category

Review Section

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多機能性抗菌ペプチドの統合的解明と疾病制御

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Altered RNA editing and malignant progression in oral squamous carcinoma.Principal Investigator

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Taget molecule of antimicrobial peptides and disease control

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Study of miRNA regulatory systems of antitumor effects by human cathelicidin.Principal Investigator

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Development of new therapy of oral infection and cancer by applying innate immunity network.Principal Investigator

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Study of antitumor effect and dendritic cells induced by human Cathelicidin hCAP18.Principal Investigator

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MMP-9/RNAiによる癌の浸潤転移抑制と細胞分化療法の開発

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Antitumor effect of gene transfection and DNA vacccine of beta-defensins

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Study of suppressions of invasion / metastasis by molecular targeted therapy using GFP exppessing transfectant of a high-invasion human tongue squamous cell carcinoma cells, SAS-H1.Principal Investigator

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Search for Invasion/Metastasis Related Genes of Oral Squamous Cell Carcinoma using Differential DisplayPrincipal Investigator

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Study of signal transduction of invasion / metastasis via PI3-kinase in the oral squamous cell carcinoma.Principal Investigator

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OKUMURA Kazuhiko 奥村一彦

奥村一彦オクムラカズヒコ