Shimizu shunichi 清水俊一

… Alternative Names

SHIMIZU Shunichi 清水俊一

清水俊一シミズシュンイチ

SIMIZU Shunichi 清水俊一

SHIMUZU Shin'ichi 清水俊一

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Researcher Number	60196516
Other IDs
Affiliation (Current)	2025: 帝京平成大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2015 – 2017: 帝京平成大学, 薬学部, 教授 2014: 横浜薬科大学, 薬学部, 教授 2009 – 2013: Showa University, 薬学部, 准教授 2003 – 2004: 昭和大学, 薬学部, 助教授 2001: Showa University school of pharmaceutical sciences assistamt Professor, 薬学部, 助教授 … More 2000: 昭和大, 薬学部, 助教授 1998: 昭和大学, 薬学部, 助教授 1996 – 1997: Researcher, Department of Pharmacology School of Pharamceutical Sciences, Showa, 薬学部, 助手 1994: 昭和大学薬学部, 助手 1993 – 1994: 昭和大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / 応用薬理学・医療系薬学 / Biological Sciences / Pharmacology in pharmacy / Respiratory organ internal medicine Except Principal Investigator 応用薬理学・医療系薬学 / Collagenous pathology/Allergology
Keywords	Principal Investigator TRPM2 / 活性酸素 / 腫瘍 / マクロファージ / ＴＲＰＭ２ / 心臓 / 単球 / 血管新生 / 過酸化水素 / 一酸化窒素 … More / 腫瘍形成 / TRPV1 / TRPA1 / TRPチャネル / 低酸素 / TRPM2阻害剤 / 固形癌 / マクロファージの極化 / 心臓機能 / ADP-ribose / マウス / 心拍数 / 虚血再灌流 / 不整脈 / 心機能 / TRPM2チャネル / ケモカイン / 腫瘍関連マクロファージ / 悪性腫瘍 / TRPM2 チャネル / サイトカイン / カルシウムイオン / 固形がん / 虚血-再灌流障害 / Ca2+透過性チャネル / 好中球 / カルシムイオン / 虚血再灌流障害 / Ca^<2+> / Th2細胞 / Th1細胞 / 酸化ストレス / カルシウムイン / 単核球 / 気管支喘息 / ウシ大動脈内皮細胞 / ETS-1 / 酸化的ストレス / 血管機能障害 / 糖尿病 / ラット糖尿病モデル / 血管内皮細胞 / 細胞障害 / テトラヒドロビオプテリン / 一酸化窒素合成酵素 … More Except Principal Investigator 血管内皮細胞 / 過酸化水素 / BH4 / 血管新生 / vascular endothelial cells / ets-1 / angiogenesis / H_2O_2 / reactive oxygen species / nitric oxide synthase / tetrahydrobiopterin / 細胞障害 / 活性酸素 / 一酸化窒素 / カルシウム応答性 / FOXP3 splicing variants / 制御性Ｔ細胞 / アレルギー・ぜんそく / 気管支喘息 / 調節性T細胞 / FOXP3スプライスバリアント / endothelisl cell / ischemic heart disease / 虚血性心疾患 / angiogenesis, / 活性酵素 / テトラヒドロバイオプテリン / 酸化窒素合成酵素 / 一酸化窒素(NO) / oxidative stress / active oxygen / nitric oxide / endothelial cells / disorder of vascular function / 電極法 / 細胞傷害 / 一酸化窒素測定法 / 一酸化窒素合成酵素 / グルタチオン / ヒロドキシラジカル / 酸化的ストレス / 血管機能障害 / CELL INJURY / MUSCLE RELAXATION / HYDROGEN PEROXIDE / ISCHEMIA-REPERFUSION / POLYMORPHONUCLEAR / NITRIC OXIDE / REACTIVE OXYGEN SPECIES / ENDOTHELIAL CELL / カルシウムイオン / 多形核白血球 / 虚血再灌流 / 白血球 / 弛緩反応 / 虚血再潅流 Less

Localization and role of TRPM2 channel in the heartPrincipal Investigator
- Principal Investigator
  
  Shimizu Shunichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Teikyo Heisei University
転写因子FOXP3スプライシングバリアントの機能とアレルギー疾患への関与
- Principal Investigator
  
  根来孝治
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Teikyo Heisei University
  Showa University
腫瘍関連マクロファージ形成における低酸素及び活性酸素感受性TRPチャネルの関与Principal Investigator
- Principal Investigator
  
  清水俊一
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Teikyo Heisei University
Attenuation of tumor growth in TRPM2 knockout mice and its mechanismPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Shunichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Yokohama College of Pharmacy
  Showa University
Aggravation mechanism of cardiac ischemia-reperfusion injury through oxidative stress-sensitive channel TRPM2Principal Investigator
- Principal Investigator
  
  SHIMIZU Shunichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
新規活性酸素感受性チャネルTRPM2の喘息への関与及び診断の指標としての可能性Principal Investigator
- Principal Investigator
  
  清水俊一
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Showa University
NOによる血管新生の促進とその機構〜転写因子ETS-1の関与〜Principal Investigator
- Principal Investigator
  
  清水俊一
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Showa University
Investigation of intrinsic factors for angiogenesis and recovery of endothelial cell injury contributed to the convalescenc of ischemic heart disease
- Principal Investigator
  
  YAMAMOTO Toshinori
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  SHOWA UNIVERSITY
糖尿病に伴うNO合成酵素の機能異常とその組織障害への関与に関する研究Principal Investigator
- Principal Investigator
  
  清水俊一
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Showa University
Relation between dysfunction of nitric oxide synthase and angiogenesis
- Principal Investigator
  
  MOMOSE Kazutaka
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Showa University
Variation of nitric oxide synthase activity in encothelial cells and effects of the variation on the cell injury
- Principal Investigator
  
  MOMOSE Kazutaka
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Showa University
INVOLVEMENT OF AN ACTIVATED POLYMORPHONUCLEAR IN CARDIOVASCULAR DISEASES
- Principal Investigator
  
  YAMAMOTO Toshinori
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Showa University

All 2017 2016 2015 2011 2010 2009

All Journal Article Presentation

[Journal Article] Tyrphostin AG-related compounds attenuate H2O2-induced TRPM2-dependent and -independent cellular responses.2017
- Author(s)
  Shinichiro Yamamoto, Takahiro Toda, Ryo Yonezawa, Takaharu Negoro, Shunichi Shimizu
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: in press Issue: 1 Pages: 68-74
- DOI
  10.1016/j.jphs.2017.05.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01409, KAKENHI-PROJECT-15K09557
[Journal Article] TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation2016
- Author(s)
  Yonezawa R, Yamamoto S, Takenaka M, Kage Y, Negoro T, Toda T, Ohbayashi M, Numata T, Nakano Y, Yamamoto T, Mori Y, Ishii M, Shimizu S
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 90 Pages: 101-113
- DOI
  10.1016/j.freeradbiomed.2015.11.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09557, KAKENHI-PROJECT-25462899, KAKENHI-PROJECT-26460494, KAKENHI-PLANNED-26111004, KAKENHI-PROJECT-24249017, KAKENHI-PROJECT-15K08197
[Journal Article] Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe2+ in human monocytic U937 cells.2015
- Author(s)
  Shimizu S, Yonezawa R, Negoro T, Yamamoto S, Numata T, Ishii M, Mori Y, Toda T.
- Journal Title
  
  The International Journal of Biochemistry & Cell Biology
  
  Volume: 68 Pages: 119-127
- DOI
  10.1016/j.biocel.2015.09.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08197, KAKENHI-PROJECT-15K09557
[Journal Article] 活性酸素感受性Ca^<2+>透過性チャネルTRPM2の活性化による炎症反応の増幅2011
- Author(s)
  清水俊一
- Journal Title
  
  生化学
  
  Volume: 83 Pages: 1100-1103
- NAID
  10030345880
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590104
[Journal Article] 活性酸素感受性Ca2+透過性チャネルTRPM2の活性化による炎症反応の増幅2011
- Author(s)
  清水俊一
- Journal Title
  
  生化学
  
  Volume: 83 Pages: 1100-1103
- NAID
  10030345880
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590104
[Presentation] 喘息患者における各FOXP3バリアント発現とその機能との関係2017
- Author(s)
  山本佳樹、根来孝治、成島道昭、秋山　晴代、清水　俊一、山本　伸一郎、戸田　雄大、高柳隆章、板橋稼頭央
- Organizer
  第66回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-15K09557
[Presentation] 過酸化水素によるTRPM2依存性および非依存性な細胞応答におけるTyrphostin AG関連化合物の阻害作用の検討2017
- Author(s)
  山本伸一郎、戸田雄大、根来孝治、清水俊一
- Organizer
  日本薬理学会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PUBLICLY-15H01409
[Presentation] 喘息患者における各FOXP3バリアント発現とその機能との関係2016
- Author(s)
  山本佳樹、根来孝治、成島道昭、秋山　晴代、清水　俊一、山本　伸一郎、戸田　雄大、高柳隆章、板橋稼頭央
- Organizer
  第65回日本アレルギー学会学術大会
- Place of Presentation
  東京国際フォーラム（東京都）
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K09557
[Presentation] マウス心臓の虚血-再灌流の進展におけるTRPM2チャネルの関与2010
- Author(s)
  廣井理人、輪島輝明、香西大輔、根来孝治、木内祐二、森泰生、清水俊一
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21590104
[Presentation] マウス心臓の虚血-再灌流障害の進展におけるTRPM2チャネルの関与2010
- Author(s)
  清水俊一, 根来孝治
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-03-16
- Data Source
  KAKENHI-PROJECT-21590104
[Presentation] 炎症性疾患の発症と進展におけるTRPM2の役割2009
- Author(s)
  廣井理人、山本伸一郎、輪島輝明、根来孝治、木内祐二、森泰生、清水俊一
- Organizer
  第5回TRPチャネル研究会
- Place of Presentation
  岡崎
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-21590104

1. NEGORO Takaharu (70218270)

# of Collaborated Projects: 6 results

# of Collaborated Products: 8 results
2. YAMAMOTO Toshinori (30112741)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. YASUDA Masako (30260079)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. ISHII Masakazu (30307061)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MOMOSE Kazutaka (80004597)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 石田行知 (50092135)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. FUNAYAMA Norio (50245875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NUMATA Tomohiro (20455223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 鈴木一 (80053891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 木内祐二 (50204821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 向後麻里 (70343499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 戸部敞 (90102368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 内藤慎二 (40253645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 戸田雄大 (30573852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中野泰子 (20155790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. ISHIDA Tomoyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Shimizu shunichi 清水 俊一

SHIMIZU Shunichi 清水 俊一

清水 俊一 シミズ シュンイチ

SIMIZU Shunichi 清水 俊一

SHIMUZU Shin'ichi 清水 俊一

Research Projects

Research Products

Co-Researchers

Localization and role of TRPM2 channel in the heartPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

転写因子FOXP3スプライシングバリアントの機能とアレルギー疾患への関与

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腫瘍関連マクロファージ形成における低酸素及び活性酸素感受性TRPチャネルの関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Attenuation of tumor growth in TRPM2 knockout mice and its mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Aggravation mechanism of cardiac ischemia-reperfusion injury through oxidative stress-sensitive channel TRPM2Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規活性酸素感受性チャネルTRPM2の喘息への関与及び診断の指標としての可能性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

NOによる血管新生の促進とその機構 〜転写因子ETS-1の関与〜Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of intrinsic factors for angiogenesis and recovery of endothelial cell injury contributed to the convalescenc of ischemic heart disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

糖尿病に伴うNO合成酵素の機能異常とその組織障害への関与に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Relation between dysfunction of nitric oxide synthase and angiogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Variation of nitric oxide synthase activity in encothelial cells and effects of the variation on the cell injury

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

INVOLVEMENT OF AN ACTIVATED POLYMORPHONUCLEAR IN CARDIOVASCULAR DISEASES

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Shimizu shunichi 清水俊一

SHIMIZU Shunichi 清水俊一

清水俊一シミズシュンイチ

SIMIZU Shunichi 清水俊一

SHIMUZU Shin'ichi 清水俊一

NOによる血管新生の促進とその機構〜転写因子ETS-1の関与〜Principal Investigator