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Oguchi Takeshi  小口 健史

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OGUCHI Takeshi  小口 健史

小口 健史  オグチ タケシ

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Researcher Number 60201399
Other IDs
Affiliation (Current) 2025: 山梨大学, 大学院総合研究部, 准教授
Affiliation (based on the past Project Information) *help 2017 – 2024: 山梨大学, 大学院総合研究部, 准教授
2015 – 2016: 山梨大学, 総合研究部, 准教授
2011 – 2013: 山梨大学, 医学工学総合研究部, 准教授
2010 – 2012: 山梨大学, 大学院・医学工学総合研究部, 准教授
2003 – 2004: UNIVERSITY OF YAMANASHI, HOSPITAL, ASSISTANT PROFESSOR, 医学部附属病院, 講師 … More
2002: UNIVERSITY OF YAMANASHI, FACULTY OF MEDICINE, ASSISTANT PROFESSOR, 医学部, 講師
1998 – 2001: 山梨医科大学, 医学部, 講師
1991: 山梨医科大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Basic Section 55050:Anesthesiology-related / Anesthesiology / Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies
Except Principal Investigator
Anesthesiology/Resuscitation studies / Basic Section 55050:Anesthesiology-related / Basic Section 55030:Cardiovascular surgery-related / Anesthesiology/Resuscitation studies / 麻酔学
Keywords
Principal Investigator
心筋保護 / 心筋虚血 / 虚血再灌流障害 / GLP-1 / イリドイド配糖体 / PI3K/Akt経路 / フラボノイド / 薬理学 / 循環器・高血圧 / アミノ酸 … More / FURA-2 / MYOCARDIAL METABOLISM / MYOCARDIAL FUNCTION / CALCIUM / ISOLATED HEART / HEPARIN / PROTAMINE / 蛍光色素法 / 心筋代謝 / 心機能 / 筋小胞体機能 / 摘出心臓標本 / ヘパリン / プロタミン / 高血糖 / プレコンディショニング / インスリン / 虚血再灌流不整脈 / 虚血再灌流 / 摘出心臓 / 摘出心筋 / TNF-α / ウリナスタチン / 周術期管理学 … More
Except Principal Investigator
c-fos / 人工心肺 / プレコンディショニング / astrocyte / allodynia / FURA-2 / MYOCARDIAL FUNCTION / CALCIUM / ISOLATED HEART / 蛍光色素法 / 心機能 / 筋小胞体機能 / 摘出心臓標本 / 麻酔薬 / 神経因性疼痛 / インスリン / Glucagon-like peptide-1 / GLP-1 / Langendorff / 脳内炎症 / 経鼻インスリン / ラット / cardiopulmonary bypass / 人工心肺装置 / 気絶心筋 / 心収縮力 / 心臓手術 / ラクトフェリン / 心筋虚血再灌流障害 / ANESTHETICS / PRECONDITIONING / ISCHEMIC HEART / AGING / 虚血心筋 / 加齢 / astroyte / neurosphere / fractalkine / MYOCARDIAL METABOLISM / PROPOFOL / ANESTHETICCS / 静脈麻酔薬 / 心筋代謝 / プロポフォール / partial nerveinjury model / Neuropathic Pain / c-Fos / CCIモデル / 部分神経損傷モデル / REPERFUSION INJURY / VOLATILE ANESTHETICS / PH ACTIVITY / MYOCYTES / H+交換系 / Na+ / H^+交換系 / Na^+ / 細胞内pH / 虚血-再灌流障害 / 吸入麻酔薬 / ischemia / rat heart / preconditioning effect / Insulin / 心筋保護 / 虚血再灌流障害 / 腹部手術 / 硬膜外フェンタニ-ル / 血中カテコラミン / 硬膜外大量フェンタニール麻酔 Less
  • Research Projects

    (16 results)
  • Research Products

    (10 results)
  • Co-Researchers

    (14 People)
  •  GLP-1受容体からみたイリドイド配糖体の心筋虚血再灌流障害に対する心保護作用の解明Principal Investigator

    • Principal Investigator
      小口 健史
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      University of Yamanashi
  •  心筋虚血再灌流障害に対するGLP-1の濃度依存性の心保護作用の解明

    • Principal Investigator
      大宮 啓輔
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      University of Yamanashi
  •  Effects of intranasal insulin administration for acute cerebral inflammation induced by cardiopulmonary bypass

    • Principal Investigator
      川上 亜希子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      University of Yamanashi
  •  Cardioprotective effect of lactoferrin via PI3K/Akt pathway against stunned myocardium

    • Principal Investigator
      Matsukawa Takashi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      University of Yamanashi
  •  Role of PI3K / Akt pathway on cardioprotective effects of flavonoids against ischemia-reperfusion injuryPrincipal Investigator

    • Principal Investigator
      Oguchi Takeshi
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      University of Yamanashi
  •  Myocardial preconditioning effects of amino acids and PI3K/Akt signaling pathwayPrincipal Investigator

    • Principal Investigator
      OGUCHI Takeshi
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      University of Yamanashi
  •  Myocardial preconditioning effects of high-dose insulin and PI3K/Akt signaling pathwayPrincipal Investigator

    • Principal Investigator
      OGUCHI Takeshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      University of Yamanashi
  •  Insulin preconditioning elevates p-Akt and cardiac contractility after reperfusion in the isolated ischemic rat heart

    • Principal Investigator
      SATO Hiroaki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      University of Yamanashi
  •  Cardio-protective effects of ulinastatin in isolated rat heartsPrincipal Investigator

    • Principal Investigator
      OGUCHI Takeshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      University of Yamanashi
  •  ROLE OF AGING ON PRECONDITIONING AND INTRACELLULAR CA2+ DYNAMICS IN THE ISOLATED RAT HEART.

    • Principal Investigator
      YAMAGUCHI Toshiaki
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      University of Yamanashi
      山梨医科大学
  •  THE ROLE OF c-fos IN INDUCING NEUROPATHIC PAIN

    • Principal Investigator
      KASHIMOTO Satoshi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      University of Yamanashi
      山梨医科大学
  •  EFFECTS OF VOLATILE ANESTHETICS ON PH ACTIVITY AND ISCHEMIC-REPERFUSION INJURY IN MYOCARDIAL CELLS

    • Principal Investigator
      KUMAZAWA Teruo
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      UNIVERSITY OF YAMANASHI (FACULTY OF MEDICINE)
  •  The Role of c-fos gene in Neuropathic Pain

    • Principal Investigator
      KASHIMOTO Satoshi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Yamanashi Medical University
  •  AGE-RELATED ANESTHETICS EFFECTS ON MYOCARDIAL CONTRACTION AND INTRACELLULAR CA2+ DYNAMICS OF ISOLATED RAT HEARTS

    • Principal Investigator
      YAMAGUCHI Toshiaki
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      YAMANASHI MEDICAL UNIVERSITY
  •  EFFECTS OF PROTAMINE ON MYOCARDIAL FUNCTION AND INIRACELLULAR Ca2+ DYNAMICS IN THE ISOLATED RAT HEARTSPrincipal Investigator

    • Principal Investigator
      OGUCHI Takeshi
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      YAMANASHI MEDICAL UNIVERSITY
  •  硬膜外へのフェンタニールを始めとするオピオイド投与による新しい麻酔法の検討

    • Principal Investigator
      KUMAZAWA Teruo
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      麻酔学
    • Research Institution
      山梨医科大学

All 2023 2019 2013 2011 2010 2004 2003

All Journal Article Presentation

  • [Journal Article] Role of the protein kinase A signaling pathway and identification of mediators in the cardioprotective effects of enteral lactoferrin for ischemia-reperfusion injury in an isolated rat heart model2023

    • Author(s)
      Omiya Keisuke、Nakadate Yosuke、Sato Hiroaki、Oguchi Takeshi、Matsuoka Toru、Kawakami Akiko、Schricker Thomas、Matsukawa Takashi
    • Journal Title

      Nutrition

      Volume: 113 Pages: 112088-112088

    • DOI

      10.1016/j.nut.2023.112088

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K08965
  • [Journal Article] Age-related changes in the cardioprotective effect of ischemic preconditioning in the isolated rat hearts : Role of intracellular calcium dynamics and oxygen free radical production2004

    • Author(s)
      Takeshi Oguchi
    • Journal Title

      American Society of Anesthesiologists Annual Meeting

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14571425
  • [Journal Article] Age-related changes in the cardioprotective effect of ischemic preconditioning in the isolated rat hearts : Role of intracellular calcium dynamics and oxygen free radical production2004

    • Author(s)
      TAKESHI OGUCHI
    • Journal Title

      ANESTHESIOLOGY A630

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571425
  • [Journal Article] Aging reduces the cardioprotective effect of isoflurane-Induced preconditioning in the isolated rat hearts2003

    • Author(s)
      Takeshi Oguchi
    • Journal Title

      American Society of Anesthesiologists Annual Meeting

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14571425
  • [Journal Article] Aging reduces the cardioprotective effect of isoflurane-Induced preconditioning in the isolated rat hearts2003

    • Author(s)
      TAKESHI OGUCHI
    • Journal Title

      ANESTHESIOLOGY A688

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571425
  • [Presentation] The Cardioprotective Effects of S-equol for Myocardial Ischemia-Reperfusion Injury is Related to PI3K/Akt Pathway in the Experimental Animal Model2023

    • Author(s)
      Mariko Yamada, Yosuke Nakadate, Akiko Kawakami, Keisuke Omiya, Takeshi Oguchi, Tanaka Makoto, Takashi Matsukawa
    • Organizer
      カナダ麻酔学会(Canadian Anesthesiologists’ Society Annual Meeting 2023 )
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09192
  • [Presentation] Which amino acids are cardioprotective against ischemia reperfusion injury ?2019

    • Author(s)
      Keisuke Omiya, Yosuke Nakadate, Toru Matsuoka, Akiko Kawakami, Hiroaki Sato, Takeshi Oguchi, Takashi Matsukawa
    • Organizer
      New Zealand Anaesthesia Annual Scientific Meeting +Annual Queenstown Update in Anaesthesia 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10955
  • [Presentation] 心臓虚血再灌流モデルにおける高用量インスリン先行投与の心筋保護効果2013

    • Author(s)
      福島久史、佐藤宏明、佐藤環、小口健史、中楯陽介、松川隆
    • Organizer
      日本麻酔科学会第60回学術集会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Data Source
      KAKENHI-PROJECT-23592280
  • [Presentation] Ulinastatin, a protease inhibitor, attenuates protamine- induced cardiotoxicity in rats by inhibiting tumor necrosis factor alpha.2011

    • Author(s)
      Hisashi Fukushima, Takeshi Oguchi,, Hiroaki Sato, Tamaki Sato, Takashi Matsukawa.
    • Organizer
      2011 Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      McCormick Place (アメリカ合衆国 シカゴ)
    • Year and Date
      2011-10-16
    • Data Source
      KAKENHI-PROJECT-22591724
  • [Presentation] Ulinastatin attenuates ischemia- reperfusion injury in the isolated rat heart2010

    • Author(s)
      Hisashi Fukushima, Takeshi Oguchi,, Tadahiki Ishiyama, Hiroaki Sato, Takashi Matsukawa.
    • Organizer
      2011 Annual Meeting of American Society of Anesthesiologists
    • Place of Presentation
      アメリカ合衆国 サンディエゴ
    • Year and Date
      2010-10-17
    • Data Source
      KAKENHI-PROJECT-22591724
  • 1.  KUMAZAWA Teruo (10092404)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  MATSUKAWA Takashi (80209519)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 4 results
  • 3.  ISHIYAMA Tadahiko (90293448)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 4.  KASHIMOTO Satoshi (60152633)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  中楯 陽介 (50597002)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 6.  IIJIMA Tetuya (70324209)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  YAMAGUCHI Toshiaki (80242650)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  野中 明彦 (90228338)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  大宮 啓輔 (30746607)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  SATO Hiroaki (20402026)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  SUGAWARA Takeshi (50303417)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  久米 正記 (50205176)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  田中 行夫 (40155180)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  川上 亜希子 (70597004)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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