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OSUGA Hitoshi  大須賀 等

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OHASUGA Hitoshi  大須賀 等

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Researcher Number 60203775
Affiliation (based on the past Project Information) *help 2007: Tokai University, Medical Research Institute, Associate Professor
2005 – 2006: 東海大学, 総合医学研究所, 助教授
2004: Tokai University, Medical Research Institute, Associate Professor, 総合医学研究所, 非常勤助教授
2000 – 2002: 東海大学, 総合医学研究所, 講師
1995: Tokai University, Neurology, Assistant, 医学部, 助手
1994: 東海大学, 医学部・内科5, 助手
Review Section/Research Field
Principal Investigator
Neurology
Except Principal Investigator
Biological Sciences / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Neurology
Keywords
Principal Investigator
apoptosis / transgenic mouse / NAIP / cell death / SMA / 神経細胞死 / 脊髄性筋萎縮症 / apoptosisi / 細胞培養 / アルツハイマー病 / ベータ-蛋白 … More
Except Principal Investigator
… More グアニンヌクレオチド交換因子 / 神経変性疾患 / 運動ニューロン / ALS2遺伝子 / guanine nucleotide exchange factor / neurodegenerative disease / motor neuron / エンドゾーム / 低分子量Gタンパク質 / ALS2タンパク質 / 筋萎縮性側索硬化症 / endosome / model animal / the ALS2 gene / amyotrophic lateral sclerosis / AIS2遺伝子 / エンドソ-ム / ALS2蛋白質 / モデル動物 / vesicle trafficking / small GTPase / ALS2 gene / familial ALS / amyotrophic laterel sclerosis / タンパク質ドメイン / 細胞内膜・小胞移送 / 細胞内膜小胞移送 / 家族性ALS / 筋萎縮性側索硬化症(ALS) / transgenic / miniature pig / HD gene / gene expression control / polyglutamine disease / neuronal cell death / Huntignton's disease / ハンチントン舞踏病 / HD遺伝子転写調節 / HDモデルミニブタ / HD遺伝子転写制御 / CAGリピート / ハンチントン病(HD) / トランスジェニック / ミニブタ / HD遺伝子 / 遺伝子発現調節 / ポリグルタミン病 / 神経細胞死 / ハンチントン病 / patch clamp technique / ion-channel / immunohistochemical staining / myotonin protein kinase / PCR method / trinucleotide repeat / myotonic dystrophy / 免疫組織化学 / DMキナーゼ / 細胞膜 / CTGリピート / 筋緊張性ジストロフィー / 3.塩基反復配列 / パッチクランプ法 / イオンチャンネル / 免疫組織染色 / Myotonin Protein Kinase / PCR法 / 3塩基反復配列 / 筋緊張性ジストロフィー症 Less
  • Research Projects

    (7 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (7 People)
  •  ALS2遺伝子の機能喪失変異による運動ニューロン疾患発症機序に関する研究

    • Principal Investigator
      HADANO Shinji
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  Generation of novel animal models for amyofrophic lateral sclerosis and studies on the molecular mechanisms underlying motor dysfunction

    • Principal Investigator
      HADANO Shinji
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokai University
  •  Study on the cellular distribution and molecular function of ALS2, a product of the novel causative gene for famrlial ALS

    • Principal Investigator
      HADANO Shinji
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Tokai University
  •  The protective effect of neuronal cell death on NAIP transgenic mousePrincipal Investigator

    • Principal Investigator
      OSUGA Hitoshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tokai University
  •  Molecular Pathogenesis of Huntington's Disease and Molecular Mechanism of Neuronal Cell Death

    • Principal Investigator
      IKEDA Joh-E
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokai University
  •  ラット培養神経細胞におけるβ-amyloid proteinの影響Principal Investigator

    • Principal Investigator
      大須賀 等
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tokai University
  •  Gene abnormality and ion-channel change in myotonic dystrophy

    • Principal Investigator
      YOSHII Fumihito
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tokai University

All 2005 2003

All Journal Article

  • [Journal Article] A Dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein.2005

    • Author(s)
      Okada, Y., Sakai, H., Kohiki, E., Suga, E., Yanagisawa, Y., Tanaka, K., Hadano, S., Osuga, H., Ikeda, J.-E.
    • Journal Title

      J.Cereb.Blood Flow Metab. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • [Journal Article] ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics.2003

    • Author(s)
      Otomo, A., Hadano, S., Okada, T., Mizumura, H., Kunita, R., Nishijima, H., Showguchi-Miyata, J., Yanagisawa, Y., Kohiki, E., Suga, E., Yasuda, M., Osuga, H., Nishimoto, T., Naurumiya, S., Ikeda, J.-E.
    • Journal Title

      Hum.Mol.Genet. 12 (14)

      Pages: 1671-1687

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14380361
  • 1.  HADANO Shinji (60281375)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 2.  ONOE Kyuichiro (50276812)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  TANAKA Kazunori (10338767)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  YOSHII Fumihito (90130103)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  YOSHITOSHI Mieko (50183702)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  IKEDA Joh-E (50266467)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  篠原 幸人 (60051504)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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