SAKAI Akiko 堺明子

… Alternative Names

堺明子サカイアキコ

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Researcher Number	60205698
Other IDs
Affiliation (based on the past Project Information) *help	2021 – 2023: 岡山大学, 医歯薬学域, 助教 2020: 岡山大学, 医歯薬学総合研究科, 助教 2016: 岡山大学, 医歯薬学総合研究科, 助教 2013 – 2015: 岡山大学, 医歯(薬)学総合研究科, 助教 2012: 岡山大学, 大学院・医歯薬学総合研究科, 助教 … More 2007: 岡山大学, 大学院・医歯薬学総合研究科, 助教 2004 – 2006: OKAYAMA UNIV., GRAD. SCHL.MED.DENT.PHARM., ASSIS. PROFESSOR, 大学院医歯薬学総合研究科, 助手 2001 – 2004: Okayama University, Graduate School of Medicine and Dentistry, Assistant, 大学院・医歯学総合研究科, 助手 1998 – 2000: 岡山大学, 医学部, 助手 1998: 岡山大学, 医学部, 医員 1995 – 1996: 岡山大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Obstetrics and gynecology / Human pathology Except Principal Investigator Biological Sciences / Pathological medical chemistry / Basic Section 55010:General surgery and pediatric surgery-related / Cancer epidemiology and prevention
Keywords	Principal Investigator SNP / CDH17 / 微小環境 / スプライシング変異 / カドヘリン / 膵がん / spermatogenesis / homologs among wide species / nuclear localization / cancer-testis gene … More / testis-specific expression / human novel protein / collagen-like domain / WD40 repeat / がん・精巣遺伝子 / 精巣特異的 / 核局在タンパク質 / コラーゲン様ドメイン / WD40リピートタンパク質 / 精子成熟過程 / 種間相同性維持 / 核局在 / 癌-精巣遺伝子 / 精巣特異的発現 / ヒト新規タンパク質 / コラーゲン様モチーフ / WD40リピート / microRNA / がん / 血漿 / miRNA / エキソソーム … More Except Principal Investigator 遺伝的多型 / ミスセンス1塩基多型 / がん体質遺伝 / 肺癌 / Two-hybrid assay / Chromosome 3p21 / チロシンホスファターゼ / 癌抑制遺伝子 / 染色体3p21 / 癌分子疫学 / リスク遺伝子型重複 / 癌体質遺伝 / 癌発症危険度 / 疾患コホート / 食道がん / 大腸がん / 頭頸部がん / 肺がん / ms-SNP / 1塩基多型 / フレームシフト変異 / ミスマッチ修復 / hMSH3遺伝子 / マイクロサテライト不安定性 / E2F4遺伝子 / WD-40リピート / 発癌機構 / BTB/POZ / Lung cancer / microRNA / myoneurin / lung cancer / p53 / Myoneurin / MYNN / Tumor suppressor / 遺伝子変異 / Loss of Heterozygosity / Yeast Two-hybrid / Cumulative Odds Ratio / Odds Ratio / Case-control Study / missense-SNP / Cancer-related Genes / Genetic Polymorphism / Cancer-predisposition / p53遺伝子 / ミスセンス単塩基多型(ms-SNP) / 遺伝的素因 / 発がん高リスク遺伝子多型 / がん体質遺伝子 / 発がん高リスク遺伝 / ミスセンス単塩基多型 / DNA修復遺伝子 / 発がん高リスク遺伝子 / 累積オッズ比 / オッズ比 / 患者-対照研究 / ミスセンス1塩某多型 / がん関連遺伝子 / Genetic diagnosis with peripheral blood / Chromosome 13q34 / loss of heterozygosity (LOH) / ING1 gene / Tumor suppressor genes / HD-PTP ; Tyrosine-phosphatase gene / p107 gene / K-ras遺伝子 / 活性化変異特異的診断 / AKT遺伝子 / 遺伝子内欠失 / 活性化変異特異的遺伝子診断 / 融合遺伝子特異的分子診断 / ヘテロ接合性消失 / 末梢血遺伝子診断 / 染色体13q34 / ヘテロ接合性消失(LOH) / ING1遺伝子 / HD-PTPチロシンホスファターゼ遺伝子 / p107遺伝子 / 癌の早期発見診断 / EGF受容体遺伝子変異 / ミスセンス１塩基多型 / コホート研究 / 癌の早期発見 / 胃がん / 早期発見診断 / がん予防 / 組み換え修復遺伝子 / DNAポリメラーゼ遺伝子 / PCNA遺伝子 / DNAポリメラーゼε遺伝子 / 核蛋白質 / 非マトリックスコラーゲン / 核局在タンパク質 Less

Cross-regulatory mechanisms of cancer-associated genes MYNN and p53 in lung cancer.
- Principal Investigator
  
  Ito Sachio
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Okayama University
CDH17多型とそれに伴うスプライシング変異による短鎖タンパク質の機能解明Principal Investigator
- Principal Investigator
  
  堺明子
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Okayama University
Interaction analysis of plasma exosome miRNA and tumorigenesisPrincipal Investigator
- Principal Investigator
  
  SAKAI AKIKO
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Okayama University
Establishment of a genetic diagnosis system for cancer predispositionand its application to cancer prevention.
- Principal Investigator
  
  SHIMIZU Kenji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cancer epidemiology and prevention
- Research Institution
  Okayama University
がん発症前高リスクに関わるがん体質遺伝素因の実体解明と試行的コホート解析
- Principal Investigator
  
  清水憲二
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Okayama University
がん発症前高リスクに関わるがん体質遺伝素因の実体解明と試行的コホート解析
- Principal Investigator
  
  清水憲二
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Okayama University
Studies on the Genetic Factors Influencing Predisposition to Cancer in High-risk Groups.
- Principal Investigator
  
  SHIMIZU Kenji
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  OKAYAMA UNIVERSITY
Functional analysis of a tumor suppressor candidate gene, HD-PTP, located on human chromosome 3p21
- Principal Investigator
  
  OUCHIDA Mamoru
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Okayama University
Analysis of a novel human protein WDC146 highly expressed in testis : for elucidation of the function during spermatogenesisPrincipal Investigator
- Principal Investigator
  
  SAKAI Akiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Okayama University
ヒト癌におけるミスマッチ修復遺伝子欠損の分子病態
- Principal Investigator
  
  清水憲二
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Okayama University
ヒト癌におけるミスマッチ修復遺伝子欠損の分子病態
- Principal Investigator
  
  清水憲二
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Okayama University
Development of Systems for Comprehensive Genetic Diagnosis of Human Cancers and for Early Detection of Cancer-patients.
- Principal Investigator
  
  SHIMIZU Kenji
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Pathological medical chemistry
- Research Institution
  OKAYAMA UNIVERSITY
WD-40リピートを持つ核内蛋白質N-raf p56の機能
- Principal Investigator
  
  清水憲二
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University
核局在プロテインキナーゼN-rafの核内信号伝達における役割
- Principal Investigator
  
  SHIMIZU Kenji
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University

All 2012 2011 2010 2003

All Journal Article Presentation

[Journal Article] Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: A case-control study.2012
- Author(s)
  Tomoda T, Nouso K, Sakai A, Ouchida M,Shimizu K.et al
- Journal Title
  
  J Gastroenterol. Hepatol
  
  Volume: 27(4) Pages: 797-804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300346
[Journal Article] TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers.2011
- Author(s)
  Sonoyama T, Sakai A, Mita Y, Ouchida M, Shimizu K. et al.
- Journal Title
  
  Mol. Med. Report
  
  Volume: 4(3) Pages: 489-495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300346
[Journal Article] Missense polymorphisms of PTPRJand PTPN13genes affect susceptibility to a variety of human cancers.2010
- Author(s)
  Mita Y, Yasuda Y, Sakai A, Yamamoto H, Toyooka S, Ouchida Ma n d Shimizu K.
- Journal Title
  
  J Cancer Res Clin Oncol
  
  Volume: 136 Pages: 249-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300346
[Journal Article] Genome-wide analyses on loss of heterozygosity in head and neck squamous cell carcinomas.2003
- Author(s)
  Beder LB, Gunduz M, Ouchida M, Fukushima K, Gunduz E, Ito S, Sakai A, Nagai N, Nishizaki K, Shimizu K.
- Journal Title
  
  Lab.Invest. 83
  
  Pages: 99-105
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213084
[Presentation] 肺腺癌のEGFR mutationに関与する遺伝子多型2011
- Author(s)
  小阪茜友、三田雄一郎、神崎浩孝、堺明子、大内田守、清水憲二、豊岡伸一、三好新一郎
- Organizer
  がん予防大会 2011 京都
- Place of Presentation
  京都府立医科大学
- Data Source
  KAKENHI-PROJECT-22300346
[Presentation] 食道癌におけるEXO1 及びIRF3 遺伝子多型と発癌リスクの解析2011
- Author(s)
  保田雪子、三田雄一郎、神崎浩孝、堺明子、大内田守、清水憲二、猶本良夫ほか
- Organizer
  がん予防大会 2011 京都
- Place of Presentation
  京都府立医科大学
- Data Source
  KAKENHI-PROJECT-22300346
[Presentation] 癌発症リスク多型遺伝子レパートリーの性および年齢区分による差異2010
- Author(s)
  清水憲二、堺明子、三田雄一郎、園山隆之、伊藤充矢、賀来春紀、山本寛斎、豊岡伸一、松原長秀、松岡順治、山本和秀、公文裕巳
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22300346
[Presentation] DNA修復・複製遺伝子多型と膵癌発症リスク2010
- Author(s)
  園山隆之、堺明子、三田雄一郎、保田雪子、河本博文、八木孝仁、吉岡正雄、三村哲重、大内田守、山本和秀、清水憲二
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22300346

1. SHIMIZU Kenji (10037286)

# of Collaborated Projects: 10 results

# of Collaborated Products: 8 results
2. OUCHIDA Mamoru (80213635)

# of Collaborated Projects: 10 results

# of Collaborated Products: 7 results
3. ITO Sachio (30335624)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
4. FUJIWARA Tazuko (70108166)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. MATSUBARA Nagahide (70314672)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 小出典男 (20142333)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SHINAGAWA Katuji (00273988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TOYOOKA Shinichi (30397880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. ODA Megumi (50160875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NOMURA Takako (20116437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SASAKI Junzo (30093686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 小倉肇 (20112146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 笹井香織 (50722162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KAKU Shunkou

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAKAI Akiko 堺 明子

堺 明子 サカイ アキコ

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CDH17多型とそれに伴うスプライシング変異による短鎖タンパク質の機能解明Principal Investigator

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Interaction analysis of plasma exosome miRNA and tumorigenesisPrincipal Investigator

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Analysis of a novel human protein WDC146 highly expressed in testis : for elucidation of the function during spermatogenesisPrincipal Investigator

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[Journal Article] Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: A case-control study.2012

Author(s)

Journal Title

Data Source

[Journal Article] TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers.2011

Author(s)

SAKAI Akiko 堺明子

堺明子サカイアキコ