HOSOKAWA Ryuji 細川隆司

Researcher Number	60211546
Other IDs
External Links
Affiliation (Current)	2021: 九州歯科大学, 歯学部, 教授
Affiliation (based on the past Project Information) *help	2003 – 2021: KYUSHU DENTAL COLLEGE, FUCALTY OF DENTISTRY, PROFESSOR, 歯学部, 教授 2002: Hiroshima University, Hospital, Lecturer, 医学部・歯学部附属病院, 講師 2001 – 2002: 広島大学, 歯学部附属病院, 講師 2001: 広島大学, 歯学部・付属病院, 講師 1999 – 2001: 広島大学, 歯学部・附属病院, 講師 1995 – 1998: 広島大学, 歯学部, 助手 1993 – 1994: 九州歯科大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator 補綴理工系歯学 / Prosthetic dentistry / Prosthodontics/ Dental materials science and / Basic Section 57050:Prosthodontics-related / Functional basic dentistry / 補綴理工系歯学 Except Principal Investigator 補綴理工系歯学 / Basic Section 57050:Prosthodontics-related / 補綴理工系歯学 / Prosthetic dentistry / Prosthodontics/ Dental materials science and / Basic Section 57080:Social dentistry-related
Keywords	Principal Investigator インプラント / 骨再生 / 歯科インプラント / FGF-2 / PRP / b-FGF / メカノバイオロジー / 歯学 / 骨細胞 / 骨吸収 … More Except Principal Investigator インプラント / 骨再生 / 口腔乾燥症 / μCT / 骨芽細胞 / チタン / 超音波 / インプラント周囲炎 / QCT / 骨質 / ハイドロキシアパタイト / 再生療法 / 自己幹細胞 / 自己血小板濃縮血漿 / 歯学 / 遺伝子多型 / 唾液腺 / 糖尿病 / 骨質診断 / 口内法X線写真 / Bone regeneration / Candida albicans / PRP / マイクロダイアリシス / 歯髄 / ヒスタミン / RGD / 接着 / 血清 / 生体活性 / 伸展 / 歯周靱帯由来上皮細胞 / 無血清培養 / Fibroblast Growth Factor / FGF-Receptor / 嚥下運動 / 高齢者 / videofluorography / 喉頭流入 / 上下顎無歯顎 / 総義歯 / オッセオインテグレーション / ナノインターフェイス / 表面性状 / 初期接着 / アクチンフィラメント / GBR / 幹細胞 / 再生医学 / SNP / 遺伝子診断 / 粘膜細胞 / 軟組織 / 創傷治癒 / 睡眠時ブラキシズム / イオン輸送担体 / 低浸透圧 / タンニン酸 / メカノバイオロジー / 口腔乾燥 / 上皮膜輸送 / イオンチャネル / 水分泌 / 陰イオンチャネル / トランスポーター / 2型糖尿病 / CT / 顎関節 / 画像診断 / Ultrasound / Computed tomography / TMJ (temporomandibular joint) / RGDペプチド / 細胞接着 / 接着分子 / Implant / Hydroxyapatite / Titanium / Osteoblast / Cell adhesion / RGD peptide / Specific adhesion / 三次元有限要素解析 / pQCT / 骨接触率 / 骨体積率 / Dental implant / Bone quality / intra-oral radiography / Three-dimensional finite element analysis / 骨梁構造 / bone quantity / trabecular structure / dental implant / 自己幹細胞(MSC) / 多血小板血漿(PRP) / ポリ乳酸顆粒 / 吸収性膜 / 多孔性アパタイト / 自己肝細胞 / Mesenchymal stem cell / Imalant / Platelet-rich-plasma / Poly-lacted acid / Resorvable membrane / Interconective porous hydroxyapatite / 粘膜免疫 / 口蓋偏桃 / 免疫 / 唾液 / IgA / カンジダ / 義歯性口内炎 / ワクチン / mucosal immunity / palatine tonsil / immunization / 再生医療 / 歯科用インプラント / Regenerative medicine / Dental implants / コラーゲン架橋 / ナノインデンテーション / ペントシジン / ビタミンK / 骨代謝 / 骨代謝マーカー / 時計生物学 / 口腔の健康 / 生活習慣病 / シフト勤務 / 口腔と全身の健康の関係 / 時間生物学 / 時間栄養学 / AGEs / インプラント周囲粘膜炎 / RAGE / 細菌叢 / 口腔機能低下症 / ドラッグ・リポジショニング / 生体利用効率 / 咀嚼能率 / 糖代謝 / 吸収カロリー / 腸内細菌叢 Less

ベイジアンネットワークによる口腔機能低下リスクの解明とフレイル予防戦略の構築Principal Investigator
- Principal Investigator
  
  細川隆司
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Kyushu Dental College
P2Y2受容体作動薬のドラッグ・リポジショニングによる口腔機能改善効果の検証
- Principal Investigator
  
  向坊太郎
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Kyushu Dental College
生体利用効率分析による補綴歯科治療の臨床栄養学的アウトカム評価の確立
- Principal Investigator
  
  青沼史子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Kyushu Dental College
最終糖化産物AGEsをターゲットとしたインプラント周囲骨吸収の発症リスク解明
- Principal Investigator
  
  野代知孝
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Kyushu Dental College
オミックス解析とノトバイオート技術を基軸としたインプラント周囲炎治療戦略
- Principal Investigator
  
  近藤祐介
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Kyushu Dental College
骨代謝分析と臨床栄養学的アプローチによる新規インプラント治療ストラテジーの構築
- Principal Investigator
  
  正木千尋
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Kyushu Dental College
宇宙医学的アプローチによる微小重力環境を用いたインプラント周囲骨吸収制御戦略Principal Investigator
- Principal Investigator
  
  細川隆司
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Kyushu Dental College
Cohort study regarding association between oral and systemic health from chronobiology
- Principal Investigator
  
  安細敏弘
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Kyushu Dental College
Molecular biological innovation for preoperative diagnosis in implant treatment by bone quality deterioration marker
- Principal Investigator
  
  Masaki Chihiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Kyushu Dental College
Strategy to control bone resorption around dental implants resorting to a criterion of pathological analysis of osteocytic ciliopathyPrincipal Investigator
- Principal Investigator
  
  Hosokawa Ryuji
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Kyushu Dental College
Challenge to the non-invasive bone quality risk inspection by collagen cross-linking analysis.Principal Investigator
- Principal Investigator
  
  HOSOKAWA Ryuji
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Kyushu Dental College
Molecullar Biological Approach to Oral Implant Treatment for Aged and Metabolically Compromized PatientsPrincipal Investigator
- Principal Investigator
  
  Hosokawa Ryuji
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Kyushu Dental College
A new treatment strategy of xerostomia based on mechano-biology and molecular medicine
- Principal Investigator
  
  Nakamoto Tetsuji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Matsumoto Dental University
  Kyushu Dental College
Development of novel therapy for type 2 diabetes induced xerostomia
- Principal Investigator
  
  Kondo Yusuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Kyushu Dental College
The effect of stress-related gene expression on nocturnal parafunction.Principal Investigator
- Principal Investigator
  
  HOSOKAWA Ryuji
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Kyushu Dental College
Risk assessment of prosthodontic treatment by peripheral benzodiazepine receptor gene polymorphism
- Principal Investigator
  
  MASAKI Chihiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Kyushu Dental College
he clarification of the mechanism of postoperative bone resorption using simulated microgravity machine.Principal Investigator
- Principal Investigator
  
  HOSOKAWA Ryuji
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Kyushu Dental College
Evaluation of proshodontic treatment on diabetes prevention using incretin as a indicator.Principal Investigator
- Principal Investigator
  
  HOSOKAWA Ryuji
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Kyushu Dental College
The development of regenerative medicine for dental implant using mechano-biological method.Principal Investigator
- Principal Investigator
  
  HOSOKAWA Ryuji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Kyushu Dental College
Low-intensity pulsed ultrasound enhances wound healing of soft tissue
- Principal Investigator
  
  HATANO Kiyotoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Kyushu Dental College
Development of risk criteria for implantitis using gene polymorphism
- Principal Investigator
  
  KOJO Tatsuro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Kyushu Dental College
3次元画像マッピング法による低価格高精度インプラントナビゲーションシステムの開発Principal Investigator
- Principal Investigator
  
  細川隆司
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Kyushu Dental College
Development of the artificial periosteum using mesenchymal stem cell for clinical application
- Principal Investigator
  
  HATANO Kiyotoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Kyushu Dental College
DEVELOPMENT OF CLINICAL SYSTEM FOR MESENCHYMAL STEM CELL REGENERATIVE THERAPY IN RESORBED ALVEOLAR BONEPrincipal Investigator
- Principal Investigator
  
  HOSOKAWA Ryuji
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Kyushu Dental College
ALVEOLAR BONE REGENERATION BY USING MESENCHYMAL STEM CELLS
- Principal Investigator
  
  HATANO Kiyotoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  補綴理工系歯学
- Research Institution
  KYUSHU DENTAL COLLEGE
Development of new prevention method for stomatitis caused by Candida induced by the use of denture in elderlies
- Principal Investigator
  
  NAGAMATSU Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Kyushu Dental College
ALVEOLAR BONE REGENERATION BY USING MESENCHYMAL STEM CELL AND PLATELET-RICH PLASMAPrincipal Investigator
- Principal Investigator
  
  HOSOKAWA Ryuji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  補綴理工系歯学
- Research Institution
  KYUSHU DENTAL COLLEGE
  Hiroshima University
自己幹細胞を用いる新しい歯槽堤再生
- Principal Investigator
  
  赤川安正
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hiroshima University
The new bone regeneraition method for the implant with mesenchymal stem cell
- Principal Investigator
  
  AKAGAWA Yasumasa
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  HIROSHIMA UNIVERSITY
チタン表面に接着する骨芽細胞のナノインターフェイスの解析
- Principal Investigator
  
  赤川安正
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hiroshima University
Development of the three dimensionsional monitoring system of osseointegration
- Principal Investigator
  
  SATO Yuji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  HIROSHIMA UNIVERSITY
An effect of FGF on periodontal ligament-derived epithelial cell proliferation and differentiation for a regenerative dental implant therapyPrincipal Investigator
- Principal Investigator
  
  HOSOKAWA Ryuji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  補綴理工系歯学
- Research Institution
  HIROSHIMA UNIVERSITY
Standard selection of the optimal implant form based on new bone quality
- Principal Investigator
  
  AKAGAWA Yasumasa
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hiroshima University
Development of cell adhesive factor coated-implant having high bone inductive ability.
- Principal Investigator
  
  AKAGAWA Yasumasa
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  HIROSHIMA UNIVERSITY
Acceleration of bone healing process by local application of the resorbable collagen pellet containing basicfibroblast growth factor (FGF-2)Principal Investigator
- Principal Investigator
  
  HOSOKAWA Ryuji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  補綴理工系歯学
- Research Institution
  HIROSHIMA UNIVERSITY
6-FGFを用いた骨形成制御に関する研究Principal Investigator
- Principal Investigator
  
  細川隆司
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hiroshima University
細胞接着分子ユ-ティングインブラントの開発に関する研究
- Principal Investigator
  
  WADAMOTO Masayoshi
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hiroshima University
次世代インプラントを目指したマラッセ残存上皮の歯周靱帯細胞に対する増殖分化制御
- Principal Investigator
  
  AKAGAWA Yasumasa
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hiroshima University
嚥下運動の客観的定量評価システムの開発 -超音波画像と顎運動・筋電図の同時解析-
- Principal Investigator
  
  SATO Yuji
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hiroshima University
マイクロダイアリシス法を用いた歯髄組織内ヒスタミン濃度のin vivo測定Principal Investigator
- Principal Investigator
  
  細川隆司
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Hiroshima University
マイクロダイアリシス法を用いたレジンモノマー歯髄組織内濃度のin vivo測定
- Principal Investigator
  
  MURAKAMI Shigeki
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Kyushu Dental College
Development of ultrasonographic computed tomography for TMJ imaging
- Principal Investigator
  
  UCHIDA Yasunari
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  補綴理工系歯学
- Research Institution
  KYUSHU DENTAL COLLEGE
基質小胞の生化学的単離法に対する再検討Principal Investigator
- Principal Investigator
  
  細川隆司
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Kyushu Dental College

[Book] 見る目が変わる!「欠損歯列」の読み方，「欠損補綴」の設計パラファンクションの病因・影響・対応の現在2013
- Author(s)
  細川隆司
- Total Pages
  164
- Publisher
  クインテッセンス出版
- Data Source
  KAKENHI-PROJECT-22390369
[Book] クインテッセンス出版2013
- Author(s)
  細川隆司
- Total Pages
  164
- Publisher
  見る目が変わる!「欠損歯列」の読み方，「欠損補綴」の設計パラファンクションの病因・影響・対応の現在
- Data Source
  KAKENHI-PROJECT-24659865
[Book] 見る目が変わる!「欠損歯列」の読み方,「欠損補綴」の設計パラファンクションの病因・影響・対応の現在2013
- Author(s)
  細川隆司
- Total Pages
  164
- Publisher
  クイテッセンス出版
- Data Source
  KAKENHI-PROJECT-24659865
[Book] 見る目が変わる!「欠損歯列」の読み方,「欠損補綴」の設計パラファンクションの病因・影響・対応の現在2013
- Author(s)
  細川隆司
- Total Pages
  164
- Publisher
  クインテッセンス出版
- Data Source
  KAKENHI-PROJECT-22390369
[Book] エッセンシャル口腔インプラント学2009
- Author(s)
  古谷野潔, 松浦正朗編著, 細川隆司分担執筆
- Total Pages
  158
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-21659447
[Book] 最新歯科衛生士教本咀嚼障害・咬合異常1 歯科補綴2009
- Author(s)
  全国歯科衛生士教育協議会監修細川隆司分担執筆
- Total Pages
  205
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-21659447
[Book] ミニマルインターベンションインプラント患者中心の治療戦略ガイド2007
- Author(s)
  細川隆司, 他
- Total Pages
  235
- Publisher
  医歯薬出版株式会社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209057
[Book] インプラント補綴の最新エビデンス2004
- Author(s)
  細川隆司, 渡邊文彦編
- Total Pages
  130
- Publisher
  医歯薬出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571846
[Journal Article] Combined effect of poor appetite and low masticatory function on sarcopenia in community‐dwelling Japanese adults aged >=75 years: A 3‐year cohort study2020
- Author(s)
  Senoo Soichiro、Iwasaki Masanori、Kimura Yumi、Kakuta Satoko、Masaki Chihiro、Wada Taizo、Sakamoto Ryota、Ishimoto Yasuko、Fujisawa Michiko、Okumiya Kiyohito、Ansai Toshihiro、Matsubayashi Kozo、Hosokawa Ryuji
- Journal Title
  
  Journal of Oral Rehabilitation
  
  Volume: n/a Pages: 643-650
- DOI
  10.1111/joor.12949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09919, KAKENHI-PROJECT-19K10449, KAKENHI-PROJECT-19K10557, KAKENHI-PROJECT-19K21587, KAKENHI-PROJECT-18H02995, KAKENHI-PROJECT-19H04352, KAKENHI-PROJECT-15K08549, KAKENHI-PROJECT-16K11868
[Journal Article] Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas2020
- Author(s)
  Kobayakawa Miki、Matsubara Takuma、Mizokami Akiko、Hiura Fumitaka、Takakura Nana、Kokabu Shoichiro、Matsuda Miho、Yasuda Hisataka、Nakamura Ichiro、Takei Yosuke、Honda Hiroaki、Hosokawa Ryuji、Jimi Eijiro
- Journal Title
  
  Cell Biochemistry and Function
  
  Volume: 2019 Pages: 118-120
- DOI
  10.1002/cbf.3476
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11645, KAKENHI-PROJECT-18K09509, KAKENHI-PROJECT-19K06918, KAKENHI-PROJECT-18H02995, KAKENHI-PROJECT-19J21202
[Journal Article] The effects of hyperglycaemia on peri-implant tissues after osseointegration2020
- Author(s)
  Yamazaki Seiya、Masaki Chihiro、Nodai Tomotaka、Tsuka Shintaro、Tamura Akiko、Mukaibo Taro、Kondo Yusuke、Ono Kentaro、Hosokawa Ryuji
- Journal Title
  
  Journal of Prosthodontic Research
  
  Volume: 64 Issue: 2 Pages: 217-223
- DOI
  10.1016/j.jpor.2019.07.007
- ISSN
  1883-1958, 1883-9207
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02995
[Journal Article] Pentosidine correlates with nanomechanical properties of human jaw bone2019
- Author(s)
  Kawamura Michihiko、Masaki Chihiro、Shibata Yo、Kondo Yusuke、Mukaibo Taro、Miyazaki Takashi、Hosokawa Ryuji
- Journal Title
  
  Journal of the Mechanical Behavior of Biomedical Materials
  
  Volume: 98 Pages: 20-25
- DOI
  10.1016/j.jmbbm.2019.06.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10188, KAKENHI-PROJECT-18H02995, KAKENHI-PROJECT-16KK0209
[Journal Article] Is Anterior Guidance a Key Factor on Planning Implant Treatment for Free-End Missing in the Posterior Mandible?2019
- Author(s)
  Nagao Mitsuharu、Masaki Chihiro、Nakao Mihoko、Ito Yoshinori、Tsuka Shintaro、Mukaibo Taro、Kondo Yusuke、Hosokawa Ryuji
- Journal Title
  
  Journal of Oral Implantology
  
  Volume: 45 Pages: 100-105
- DOI
  10.1563/aaid-joi-d-17-00237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02995
[Journal Article] Implant-supported fixed prosthesis improves nutrient intake in patients with partial edentulous posterior regions2019
- Author(s)
  Fukahori Shinji、Kondo Yusuke、Nodai Tomotaka、Aonuma Fumiko、Tamura Akiko、Tsuka Shintaro、Mukaibo Taro、Masaki Chihiro、Hosokawa Ryuji
- Journal Title
  
  Journal of Prosthodontic Research
  
  Volume: 63 Issue: 4 Pages: 411-414
- DOI
  10.1016/j.jpor.2019.03.007
- ISSN
  1883-1958, 1883-9207
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02995
[Journal Article] Krüppel-like factor 5 (Klf5) regulates expression of mouse T1R1 amino acid receptor gene (<i>Tas1r1</i>) in C2C12 myoblast cells2019
- Author(s)
  HIRATA Yuki、TOYONO Takashi、KOKABU Shoichiro、OBIKANE Yui、KATAOKA Shinji、NAKATOMI Mitsushiro、MASAKI Chihiro、HOSOKAWA Ryuji、SETA Yuji
- Journal Title
  
  Biomedical Research
  
  Volume: 40 Issue: 2 Pages: 67-78
- DOI
  10.2220/biomedres.40.67
- NAID
  130007632092
- ISSN
  0388-6107, 1880-313X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02995, KAKENHI-PROJECT-18K09525, KAKENHI-PROJECT-16K11455
[Journal Article] The effect of low-intensity pulsed ultrasound on wound healing using scratch assay in epithelial cells2016
- Author(s)
  Yujiro Iwanabe, Chihiro Masaki, Akiko Tamura, Sintaro Tsuka, Taro Mukaibo, Yusuke Kondo, Ryuji Hosokawa
- Journal Title
  
  Journal of Prosthodontic Research
  
  Volume: 60 Issue: 4 Pages: 308-314
- DOI
  10.1016/j.jpor.2016.03.002
- NAID
  130005172122
- ISSN
  1883-1958, 1883-9207
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253103
[Journal Article] Effects of Beverage Ingredients on Salivary Fluid Secretion with an ex Vivo Submandibular Gland Perfusion System:Tannic Acid as a Key Component for the Inhibition of Saliva Secretion2015
- Author(s)
  Imamura A, Nakamoto T, Mukaibo T, Munemasa T, Kondo Y, Kidokoro M, Masaki C, Hosokawa R.
- Journal Title
  
  Effects of Beverage Ingredients on Salivary Fluid Secretion with an ex Vivo Submandibular Gland Perfusion System: Tannic Acid as a Key Component for the Inhibition of Saliva Secretion.
  
  Volume: 5 Pages: 12-18
- DOI
  10.4236/ojst.2015.51003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293397, KAKENHI-PROJECT-26861648
[Journal Article] Bone Aging by Advanced Glycation End Products: A Multiscale Mechanical Analysis2015
- Author(s)
  9.Ganeko K., Masaki C., Shibata Y., Kondo Y., Mukaibo T., Nakamoto T., Miyazaki T., Hosokawa R.
- Journal Title
  
  Journal of Dental Research
  
  Volume: 94 Pages: 1684-1690
- DOI
  10.1177/0022034515602214
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K11222, KAKENHI-PROJECT-25253103
[Journal Article] Sleep bruxism is affected by peripheral benzodiazepine receptor gene polymorphisms2014
- Author(s)
  Takaya Murakami, Chihiro Masaski, Hidetaka Takahashi, Michiko Makino, Taro Mukaibo, Yusuke Kondo, Tetsuji Nakamoto, Ryuji Hosokawa
- Journal Title
  
  International journal of stomatology & occlusion medicine
  
  Volume: 7 Pages: 13-17
- DOI
  10.1007/s12548-013-0101-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592926, KAKENHI-PROJECT-25670826
[Journal Article] Na+-K+-2Cl- cotransporter-mediated fluid secretion increases under hypotonic osmolarity in the mouse submandibular salivary gland.2014
- Author(s)
  Kidokoro M, Nakamoto T, Mukaibo T, Kondo Y, Munemasa T, Imamura A, Masaki C, Hosokawa R
- Journal Title
  
  American Journal of Physiology Renal Physiology
  
  Volume: 306(10)
- DOI
  10.1152/ajprenal.00709.2012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24890215, KAKENHI-PROJECT-25293397
[Journal Article] Low-intensity pulsed ultrasound enhances palatal mucosa wound healing in rats2013
- Author(s)
  T. Maeda, C. Masaki, M. Kanao, Y. Kondo, A. Ohta, T. Nakamoto, R. Hosokawa
- Journal Title
  
  Journal of Prosthodontic Research
  
  Volume: 57 Issue: 2 Pages: 1498-503
- DOI
  10.1016/j.jpor.2012.11.001
- NAID
  130004546666
- ISSN
  1883-1958, 1883-9207
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390369, KAKENHI-PROJECT-24659865
[Journal Article] Clinical Evaluation of Dental Metal Hazards and Therapeutic Effects of Shortwave Diathermy in Dental Medicine2013
- Author(s)
  C. Mukai, T. Nakamoto, Y. Kondo, A. Ohta, C. Masaki, R. Hosokawa
- Journal Title
  
  International Journal of Prosthodontics and Restorative Dentistry
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659865
[Journal Article] The effects of low-intensity pulsed ultrasound exposure on gingival cells2012
- Author(s)
  R. Shiraishi, C. Masaki, A. Toshinaga, T. Okinaga, T. Nishihara, N. Yamanaka, T. Nakamoto, R. Hosokawa
- Journal Title
  
  J Periodontol
  
  Volume: 82 Pages: 1498-1503
- DOI
  10.1902/jop.2011.100627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390369
[Journal Article] The Tumor Necrosis Factor-Alpha Gene-857 Single-Nucleotide Polymorphism Associated with Early Implant Failure in Asian Patients2011
- Author(s)
  Y. Murashima, C. Masaki, M. Makino, T. Kojo, T. Nakamoto, R. Hosokawa.
- Journal Title
  
  International Journal of Oral Implantology and Clinical Research
  
  Volume: 2 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592464
[Journal Article] 21世紀の戦略的補綴 20世紀に何を残して21世紀に何を生かすのかインプラント補綴の将来像をみつめる2005
- Author(s)
  細川隆司
- Journal Title
  
  ザ・クインテッセンス 24・2
  
  Pages: 61-70
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591964
[Journal Article] PRP(plate-rich-plasma)の臨床応用2002
- Author(s)
  細川隆司
- Journal Title
  
  広大歯誌 34
  
  Pages: 111-113
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571846
[Journal Article] MECHANISM OF PRP(PLATELET-RICH PLASMA) ENHANSED TISSUE REGENERATION2002
- Author(s)
  HOSOKAWA, R et al.
- Journal Title
  
  The Dental Out-look. 100
  
  Pages: 1230-1243
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591964
[Journal Article] PRP(plate-rich-plasma)による組織再生促進のメカニズム-臨床への展開と今後の課題-2002
- Author(s)
  細川隆司他
- Journal Title
  
  歯界展望 100
  
  Pages: 1230-1243
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571846
[Journal Article] MECHANISM OF PRP (PLATELET-RICH PLASMA) ENHANSED TISSUE REGENERATION2002
- Author(s)
  HOSOKAWA, R et al.
- Journal Title
  
  The Dental Out-look 100
  
  Pages: 1230-1243
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571846
[Journal Article] CLINICAL APPLICATION OF PRP(PLATELET-RICH PLASMA)2002
- Author(s)
  HOSOKAWA, R
- Journal Title
  
  J Hiroshima Univ. Dent. Soc. 34
  
  Pages: 111-113
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591964
[Journal Article] CLINICAL APPLICATION OF PRP (PLATELET-RICH PLASMA)2002
- Author(s)
  HOSOKAWA, R
- Journal Title
  
  J Hiroshima Univ.Dent.Soc. 34
  
  Pages: 111-113
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571846
[Presentation] Effects of post-osseointegration hyperglycemia on peri-implant tissues2019
- Author(s)
  Chihiro Masaki, Seiya Yamazaki, Tomotaka Nodai, Yusuke Kondo, Kentaro Ono, Ryuji Hosokawa
- Organizer
  97th general session and exhibition of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02995
[Presentation] Dental Implant Treatment for Aged and Metabolically Compromised Patients: A New Biomedical Approach2018
- Author(s)
  Hosokawa R
- Organizer
  China Prosthodontic Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02995
[Presentation] The Effect of LIPUS against Wound Healing in Epithelial Cells2016
- Author(s)
  Yujiro Iwanabe, Chihiro Masaki, Akiko Tamura, Shintaro Tsuka, Taro Mukaibo, Yusuke Kondo, Ryuji Hosokawa
- Organizer
  The 94th General Session & Exhibition of the IADR
- Place of Presentation
  Seoul
- Year and Date
  2016-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253103
[Presentation] Risk management of replacing missing teeth with Implants2016
- Author(s)
  RYUji HOSOKAWA
- Organizer
  Asian Academy of Osseointegration
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2016-06-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15713
[Presentation] Salivary dysfunction in dibbetic KK-Ay mouse model2015
- Author(s)
  Munemasa T., Mukaibo T., Kondo Y., Miyagi Y. Masaki C., Hosokawa R., Nakamoto T.
- Organizer
  第57回　日本歯科基礎医学会
- Place of Presentation
  朱鷺メッセ　新潟コンベンションセンター（新潟）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-25293397
[Presentation] 低出力超音波パルスは歯肉創傷治癒モデルの創閉鎖を促進する2015
- Author(s)
  我如古清太，正木千尋，柴田陽，向坊太郎，近藤祐介，中本哲自，宮崎隆，細川隆司
- Organizer
  第124回日本補綴歯科学会学術大会
- Place of Presentation
  大宮
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-25253103
[Presentation] マウス顎下腺灌流法による上皮膜輸送機能解析　膜タンパクと水分泌との関係について2015
- Author(s)
  中本哲自、近藤祐介、向坊太郎、城所愛美、今村敦、宗政翔、正木千尋、細川隆司
- Organizer
  第57回　日本歯科基礎医学会　サテライトシンポジウム
- Place of Presentation
  朱鷺メッセ　新潟コンベンションセンター（新潟）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25293397
[Presentation] インプラント治療における骨質の術前診断は可能か？ ―Advanced glycation end products (AGEs)による骨質劣化の検討―2014
- Author(s)
  我如古清太，正木千尋，妹尾吉則，向井知理，向坊太郎，近藤祐介，中本哲自，細川隆司
- Organizer
  日本補綴歯科学会第123回学術大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25253103
[Presentation] Microstructural analysis of bone strength in rabbits with hyperhomocysteinemia2014
- Author(s)
  K. Ganeko, C. Masaki, Y. Seo, C. Mukai, T. Mukaibo, Y. Kondo, T. Nakamoto and R. Hosokawa
- Organizer
  IADR general session & exhibition
- Place of Presentation
  CAPE TOWN, SOUTH AFRICA
- Data Source
  KAKENHI-PROJECT-25253103
[Presentation] 糖尿病の発症と唾液分泌量の変化2014
- Author(s)
  宗政翔，向坊太郎，近藤祐介，正木千尋，中本哲自，細川隆司
- Organizer
  平成26年度　公益社団法人日本補綴歯科学会九州支部学術大会
- Place of Presentation
  福岡県歯科医師会館
- Year and Date
  2014-08-24
- Data Source
  KAKENHI-PROJECT-25293397
[Presentation] 糖尿病の発症と唾液分泌量の変化～灌流腺組織法を用いたKKAy糖尿病モデルマウス解析～2014
- Author(s)
  宗政翔，向坊太郎，近藤祐介，正木千尋，中本哲自，細川隆司
- Organizer
  平成26年度　公益社団法人日本補綴歯科学会九州支部学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-08-24
- Data Source
  KAKENHI-PROJECT-25463011
[Presentation] 低出力超音波(LIPUS)治療器による軟組織創傷治癒の促進効果2013
- Author(s)
  向坊太郎,三隅沙織理,村上貴也,我如古清太,細川隆司
- Organizer
  日本口腔インプラント学会九州支部会
- Place of Presentation
  大分
- Year and Date
  2013-01-20
- Data Source
  KAKENHI-PROJECT-24659865
[Presentation] 低出力超音波(LIPUS)治療器による軟組織創傷治癒の促進効果2013
- Author(s)
  向坊太郎,三隅沙織理,村上貴也,我如古清太,細川隆司
- Organizer
  日本口腔インプラント学会九州支部会
- Place of Presentation
  大分
- Year and Date
  2013-01-20
- Data Source
  KAKENHI-PROJECT-22390369
[Presentation] インプラント治療の評価2009
- Author(s)
  細川隆司
- Organizer
  第13回日本顎顔面インプラント学会総会・学術大会シンポジウム
- Place of Presentation
  佐賀
- Year and Date
  2009-12-13
- Data Source
  KAKENHI-PROJECT-21659447
[Presentation] 口元のエステティクスとアンチエイジング2009
- Author(s)
  細川隆司
- Organizer
  平成21年度(社)日本補綴歯科学会九州支部会市民フォーラム
- Place of Presentation
  福岡
- Year and Date
  2009-10-11
- Data Source
  KAKENHI-PROJECT-21659447
[Presentation] β-Thymosinsが抜歯窩治癒過程にあたえる効果2009
- Author(s)
  赤崎洋介、足立和貴、金尾将人、前田崇雄、正木千尋、中本哲自、松尾拡、細川隆司
- Organizer
  第26回日本口腔インプラント学会九州支部学術大会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-19592255
[Presentation] 口腔インプラントの現状2009
- Author(s)
  細川隆司
- Organizer
  日本歯科医学会平成21年度学術講演会基調講演
- Place of Presentation
  山梨
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-21659447
[Presentation] 口腔インプラントの現状2009
- Author(s)
  細川隆司
- Organizer
  日本歯科医学会学術講演会シンポジウム
- Place of Presentation
  和歌山
- Year and Date
  2009-08-30
- Data Source
  KAKENHI-PROJECT-21659447
[Presentation] 進行性骨化性線維異形成症(FOP)におけるALK2変異(R206H)はBMPシグナルを増強する2008
- Author(s)
  伊東佑記, 細川隆司, 自見英治郎
- Organizer
  平成20年度(社)日本補綴歯科学会九州・中国・四国支部合同学術大会
- Place of Presentation
  大分
- Data Source
  KAKENHI-PROJECT-19592255
[Presentation] Thymosinβ4はNF-κBシグナルを抑制することにより抗炎症作用を示す2008
- Author(s)
  丸山俊正、細川隆司、自見英治郎
- Organizer
  平成20年度日本補綴歯科学会九州・中国・四国支部合同学術大会、大分
- Place of Presentation
  大分
- Data Source
  KAKENHI-PROJECT-19592255
[Presentation] マウス由来歯肉上皮細胞に及ぼす低出力パルス超音波の影響2008
- Author(s)
  白石龍太郎、正木千尋、壽永旭博、中本哲自、細川隆司
- Organizer
  第21回日本歯科医学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19592255
[Presentation] 進行性骨化性線維異形成症(FOP)におけるALK2変異(R206H)はBMPシグナルを増強する2008
- Author(s)
  伊東佑記、細川隆司、自見英治郎
- Organizer
  平成20年度日本補綴歯科学会九州・中国・四国支部合同学術大会、大分
- Place of Presentation
  大分
- Data Source
  KAKENHI-PROJECT-19592255
[Presentation] 進行性骨化性線維症(FOP)の発症を司るBMP情報伝達機構の解明2008
- Author(s)
  丸山俊正、伊東佑記、正木千尋、中本哲自、細川隆司
- Organizer
  第38回日本口腔インプラント学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19592255
[Presentation] 口腔粘膜サンプルを用いた遺伝子多形解析2008
- Author(s)
  村嶋勇飛、正木千尋、中本哲自、細川隆司
- Organizer
  第21回日本歯科医学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19592255
[Presentation] Inflammatory mediators induced by mechanical stress in gingival epithelial cell2008
- Author(s)
  Toshinaga, A., Masaki, C., Hosokawa, R., Nishihara, T.
- Organizer
  86^<th> General Session & Exhibition of the IADR
- Place of Presentation
  Toronto
- Year and Date
  2008-06-28
- Data Source
  KAKENHI-PROJECT-19592255
[Presentation] Thymosinβ4はNF-кBシグナルを抑制することにより抗炎症作用を示2008
- Author(s)
  丸山俊正, 自見英治郎, 細川隆司
- Organizer
  平成20年度(社)日本補綴歯科学会九州・中国・四国支部合同学術大会
- Place of Presentation
  大分
- Data Source
  KAKENHI-PROJECT-19592255
[Presentation] マウス由来歯肉上皮細胞に及ぼす低出力パルス超音波の影響について2008
- Author(s)
  白石龍太郎、正木千尋、壽永旭博、中野宏俊、古味伸一、寺田征彦、中本哲自、細川隆司
- Organizer
  第38回日本口腔インプラント学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19592255
[Presentation] The Analysis of Gene Polymorphism using phe29 DNA Polymerase from Buccal Swab2008
- Author(s)
  Murashima, Y., Masaki, C., Tomoeda, K., Kharouf, E., Nakamoto, T., Hosokawa, R.
- Organizer
  4th Scientific Meeting of the Asian Academy of Osseointegration
- Place of Presentation
  Hiroshima
- Data Source
  KAKENHI-PROJECT-19592255
[Presentation] メカニカルストレスを負荷した歯肉上皮細胞における炎症反応について2008
- Author(s)
  壽永旭博、細川隆司、西原達次
- Organizer
  第50回歯科基礎医学会学術大会ならびに総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19592255
[Presentation] 胸腺ペプチド(TB4)による抗炎症作用の分子機構の解明2008
- Author(s)
  伊東佑記、丸山俊正、正木千尋、中本哲自、細川隆司
- Organizer
  第38回日本口腔インプラント学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19592255
[Presentation] KK-Ay糖尿病モデルマウスにおける顎下腺の組織学的および生理学的解析
- Author(s)
  宗政翔，向坊太郎，近藤祐介，正木千尋，中本哲自，細川隆司
- Organizer
  第56回歯科基礎医学会学術大会・総会
- Place of Presentation
  福岡
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25463011
[Presentation] 非酵素的コラーゲン架橋によって骨強度の劣化は起るか？
- Author(s)
  我如古清太、正木千尋、駒井英基、岡本耕造、細川隆司
- Organizer
  第44回　日本口腔インプラント学会学術大会
- Place of Presentation
  東京
- Year and Date
  2014-09-12 – 2014-09-14
- Data Source
  KAKENHI-PROJECT-25253103
[Presentation] 骨質劣化におけるコラーゲン架橋構造の及ぼす影響
- Author(s)
  我如古清太、正木千尋、柴田陽、向坊太郎、近藤祐介、中本哲自、宮﨑隆、細川隆司
- Organizer
  日本補綴歯科学会　第124回　学術大会
- Place of Presentation
  埼玉
- Year and Date
  2015-05-30 – 2015-05-31
- Data Source
  KAKENHI-PROJECT-25253103
[Presentation] KK-Ay糖尿病モデルマウスにおける顎下腺の組織学的および生理学的解析
- Author(s)
  宗政翔，向坊太郎，近藤祐介，正木千尋，中本哲自，細川隆司
- Organizer
  第56回歯科基礎医学会学術大会・総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25293397

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70. 片岡真司

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HOSOKAWA Ryuji 細川 隆司

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ベイジアンネットワークによる口腔機能低下リスクの解明とフレイル予防戦略の構築Principal Investigator

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宇宙医学的アプローチによる微小重力環境を用いたインプラント周囲骨吸収制御戦略Principal Investigator

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Strategy to control bone resorption around dental implants resorting to a criterion of pathological analysis of osteocytic ciliopathyPrincipal Investigator

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Challenge to the non-invasive bone quality risk inspection by collagen cross-linking analysis.Principal Investigator

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Molecullar Biological Approach to Oral Implant Treatment for Aged and Metabolically Compromized PatientsPrincipal Investigator

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The effect of stress-related gene expression on nocturnal parafunction.Principal Investigator

HOSOKAWA Ryuji 細川隆司