DOHI Makoto 土肥眞

Researcher Number	60222155
Affiliation (based on the past Project Information) *help	2011: 東京大学, 医学部附属病院, 講師 2007: The University of Tokyo, Faculty of Medicine,, Assistant professor 2006: 東京大学, 医学部附属病院, 講師 2005: 東京大学, 保健センター, 助手 2003: The University of Tokyo, Health Service Center, Research Associate, 保健管理センター, 助手 … More 2001 – 2002: 東京大学, 医学部附属病院, 助手 1999 – 2001: University of Tokyo, Faculty of Medicine, Assistant, 医学部・附属病院, 助手 1998: 東京大学, 医学部・付属病院, 助手 1998: University of Tokyo, Faculty of Medicine, 医学部付属病院, 助手 1998: 東京大学, 医学部附属病院, 助手 1997: 東京大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine Except Principal Investigator 内科学一般 / Biological Sciences / Respiratory organ internal medicine
Keywords	Principal Investigator 気管支喘息 / マウスモデル / 気道炎症 / mouse model / hydroxyproline / airway remodeling / interleukin 10 / bronchial asthma / 遺伝子治療 / 樹状細胞 … More / 肺胞マクロファージ / ブレオマイシン / TGF-β / 肺線維化 / ハイドロキシプロン / リモデリング / ハイドロキシプロリン / 気道リモデリング / インターロイキン10 / Repair factor / Hepatocyte growth factor / Bronchial asthma / 肝細胞増殖因子(MGF) / 気管支上皮細胞 / 気道過敏性 / 動物モデル / 修復因子 / 肝細胞増殖因子 / アレルギー / ペリリルアルコール(POH) / メバロン酸代謝 / スタチン製剤 … More Except Principal Investigator T細胞レセプター / IL-10 / T cell receptor / T細胞クローン / IgE / 経口トレランス / メチル化 / Repair / Pulmonary Fibrosis / Bleomycin / Transforming Growth Factor β-1 / Hepatocyte Growth Factor / 再生因子 / インターフェロンガンマ / TGEβ-1 / 修復 / 肺線維症 / ブレオマイシン / TGFβ-1 / 肝細胞増殖因子 / dendritic cells / Peyer's patch / T cells / Oral tolerance / 樹状細胞 / パイエル板 / T細胞 / cell therapy / gene transduction / antigen-specific immunotherapy / Immune diseases / レトロウイルス / レトロウィルス / リンパ球 / 免疫細胞療法 / 遺伝子導入 / 抗原特異的免疫療法 / 免疫疾患 / systemic lupus erythematosus / rheumatoid arthritis / T cell clone / antigen-specific T cells / Autoimmune diseases / リコンビナント抗原 / 皮膚筋炎・多発筋炎 / 全身エリテマトーデス / 標的抗原 / 全身性エリテマトーデス / 慢性関節リウマチ / 抗原特異的T細胞 / 全身性自己免疫疾患 / Derf2 / Lactobacillus / oral tolerance / mite allergy / IgE抗体 / Der fII cDNA / Derf2 cDNA / Derf2cDNA / ダニ抗原 / 大腸菌 / 乳酸菌 / ダニアレルギー / 自己免疫疾患 / レトロウィルスベクター / 免疫制御 / NKT細胞 / ゲノム / SNP / 遺伝子不活化 / 脱メチル化 Less

アレルギー性気道炎症に対するイソプレノイドの抑制効果についての実験的研究Principal Investigator
- Principal Investigator
  
  土肥眞
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The University of Tokyo
An experimental research on new therapy of bronchial asthma through modulation of dendritic cell functions by IL-10Principal Investigator
- Principal Investigator
  
  DOHI Makoto
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The University of Tokyo
免疫担当細胞を用いた免疫疾患特異的なゲノム上での転写活性化領域マッピングの試み
- Principal Investigator
  
  SAWADA Tetsuji
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
An experimental study on the control of bronchial asthma by a regenerating factor of bronchial epithelial cellsPrincipal Investigator
- Principal Investigator
  
  DOHI Makoto
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  The University of Tokyo
免疫担当細胞を用いた免疫疾患特異的なゲノム上での転写活性化領域マッピングの試み
- Principal Investigator
  
  YAMAMOTO Kazuhiko
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
抗原特異的T細胞レセプターを導入したNKT細胞による抗原特異的免疫制御の可能性
- Principal Investigator
  
  山本一彦
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Establishment of antigen-specific regulatory T cell lines induced by oral tolerance and the application to immunotherapy
- Principal Investigator
  
  YAMAMOTO Kazuhiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
EXPERMENTEAL STUDY ON THE CDNTROL OF PULMONARY FIBROSIS BY ENHANCING HGF/c-MET SYSTEM
- Principal Investigator
  
  TANAKA Ryoichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  THE UNIVERSITY OF TOKYO
Establishment of antigen-specific immunotherapy with artificial lymphocytes genetically engineered by antigen specific receptor and functional genes.
- Principal Investigator
  
  YAMAMOTO Kazuhiko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Analyses of antigen-specific T cells in systemic types of autoimmune disorders.
- Principal Investigator
  
  YAMAMOTO Kazuhiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Prevention of mite allergy by oral administration of Lactobacillus transformed with expression vector carrying Derf2-cDNA.
- Principal Investigator
  
  SUKO Matsunobu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Tokyo National University of Fine Arts and Music

All 2013 2007 2006 2005

All Journal Article Presentation Book

[Book] ステロイドハンドブック:呼吸器疾患2007
- Author(s)
  土肥眞
- Total Pages
  47
- Publisher
  羊土社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590782
[Book] 樹状細胞と呼吸器疾患、Annual Review 呼吸器 20072007
- Author(s)
  土肥眞
- Publisher
  中外医薬社
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] アレルギー疾患と免疫異常:気管支喘息2013
- Author(s)
  土肥眞
- Journal Title
  
  medicina
  
  Volume: 50 Pages: 468-472
- Data Source
  KAKENHI-PROJECT-23591137
[Journal Article] Prolonged allergen challenge in murine nasal allergic rhinitis : nasal airway remodeling and adaptation of nasal airway responsiveness2007
- Author(s)
  Nakaya M, Dohi M, Okunishi K, Nakagome K, Tanaka R, Imamura M, Yamamoto K, Kaga K.
- Journal Title
  
  Laryngoscope 117
  
  Pages: 881-885
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice.2007
- Author(s)
  0kunishi K, Dohi M, Fujio K, et. al.
- Journal Title
  
  The Journal of Immunology 179
  
  Pages: 5504-5513
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice.2007
- Author(s)
  Okunishi K, Dohi M, Fujio K, et. al.
- Journal Title
  
  The Journal of Immunology 179
  
  Pages: 5504-5513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] IL-5-induced hypereosinophilia suppresses thee antigen-inudced immune response via a TGF-beta-dependent mechanism.2007
- Author(s)
  Nakagome K, Dohi M, Okunishi K, et. al.
- Journal Title
  
  The Journal of Immunology 179
  
  Pages: 284-294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] IL-5-induced hypereosinophilia suppresses the antigen-inudced immuneresponse via a TGE-beta-dependent mechanism.2007
- Author(s)
  Nakagome K, Dohi M, Okunishi K, et. al.
- Journal Title
  
  The Journal of Immunology 179
  
  Pages: 284-294
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] IL-5-induced hypereosinophilia suppresses the antigen-inudced immune response via a TGF-beta-dependent mechanism2007
- Author(s)
  Nakagome K, Dohi M, Okunishi K, Tanaka R, Kouro R, Kano MR, Miyazono K, Miyazaki J, Takatsu K, Yamamoto K.
- Journal Title
  
  J Immunol 179
  
  Pages: 284-294
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] Severe airflow limitation in two patients with systemic lupus erythematosus: effect of inhalation of anticholinergic2007
- Author(s)
  Kawahata K, Yamaguchi M, Dohi M, et. al.
- Journal Title
  
  Modern Rheumatology 18
  
  Pages: 52-56
- NAID
  10024149772
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice2007
- Author(s)
  Okunishi K, Dohi M, Fujio K, Nakagone K, Tabata Y, Okasora T, seki M, Shibuya M, Imamura M, Harada H, Tanaka R, Yamamoto K.
- Journal Title
  
  J Immunol 179
  
  Pages: 5504-5513
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] Noninvasive system for evaluating allergen-induced nasal hypersensitivity in murine allergic rhinitis.2006
- Author(s)
  Nakaya M, Dohi M, et al.
- Journal Title
  
  Laboratory Investigation 86(9)
  
  Pages: 917-926
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] Splenic dendritic cells induced by oral antigen administration are important for the transfer of oral tolerance in an experimental model of asthma2006
- Author(s)
  Nagatani K, Dohi M, Nakagone K, Tanaka R, To Y, Okunishi K, Komagata N, Yamamoto K.
- Journal Title
  
  J Immunol 176
  
  Pages: 1401-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] In vivo IL-I0 gene delivery attenuates bleomycin-indiced pulonary fibrosis by inhibiting the production and activation of TGF-β in the lung.2006
- Author(s)
  Nakagome K, Dohi M, et al.
- Journal Title
  
  Thorax 61(10)
  
  Pages: 886-894
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] In vivo IL-10 gene delivery attenuates bleomycin induced pulmonary fibrosis by inhibiting the production and activation of TGF-β in the lung2006
- Author(s)
  Nakagome K, Dohi M, Okunishi K, Tanaka R, Miyazaki J, Yamamoto K.
- Journal Title
  
  Thorax 61
  
  Pages: 886-894
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] Noninvasive system for evaluating allergen-induced nasal hypersensitivity in murine allergic rhinitis2006
- Author(s)
  Nakaya M, Dohi M, Okunishi K, Nakagome K, Tanaka R, Imamura M, Baba S, Takeuchi N, Yamamoto K, and Kimitaka K.
- Journal Title
  
  Lab Invest 86
  
  Pages: 917-926
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] Splenic dendritic cells induced by oral antigen administration are important for the transfer of oral tolerance in an experimental model of asthma.2006
- Author(s)
  Nagatani K, Dohi M, et al.
- Journal Title
  
  Journal of Immunology 176
  
  Pages: 1401-1409
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specific systemic immune response in a mouse model of allergic airway inflammation.2005
- Author(s)
  Nakagome K, Dohi M, et al.
- Journal Title
  
  Journal of Immunology 174
  
  Pages: 6955-6966
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] A novel role of hepatocyte growth factor as an immune-regulator through suppressing dendritic cell functions.2005
- Author(s)
  Okunishi K, Dohi M, et al.
- Journal Title
  
  Journal of Immunology 175
  
  Pages: 4745-4753
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] Antigen-sensitizedCD4+CD62+low memory/effector T helper 2 cells can induce airway hyperresponsiveness in an antigen-free setting.2005
- Author(s)
  Nakagome K, Dohi M, et al.
- Journal Title
  
  Respiratory Research 28
  
  Pages: 46-46
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] Antigen-sensitized CD4+CD62+Llow memory/effector T helper 2 cells can induce airway hyperresponsiveness in an antigen-free setting2005
- Author(s)
  Nakagome K, Dohi M, Okunishi K, To Y, Sato A, Komagata Y, Nagatani K, Tanaka R, Yamamoto K.
- Journal Title
  
  Respir Res 28 ; 6(1)
  
  Pages: 46-46
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590782
[Journal Article] A novel role of hepatocyte growth factor as an immune-regulator through suppressing dendritic cell functions2005
- Author(s)
  Okunishi K, Dohi M, Nakagome K, Tanaka R, Mizuno S, Matsumoto K, Nakamura T, Miyazaki J, Yamamoto K.
- Journal Title
  
  J Immunol 175
  
  Pages: 4745-53
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590782
[Presentation] Hepatocyte growth factor suppresses antigen-induced immune responses with modukation of dendritic cell function and without induction of CD4+Foxp3+ regulatory cells.2007
- Author(s)
  奥西勝秀、土肥眞、藤尾圭志、他。
- Organizer
  日本免疫学会総会学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-17
- Data Source
  KAKENHI-PROJECT-17590782
[Presentation] IL-5-induced hypereosinophilia suppresses the antigen-inudced immune response via a TGF-beta-dependent mechanism2007
- Author(s)
  Nakagome K, Dohi M, Okunishi K, et. al.
- Organizer
  Annual meetings of Japanese Respiratory Society
- Place of Presentation
  Tokyo.
- Year and Date
  2007-05-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590782
[Presentation] IL-5遺伝子導入は好酸球増多を誘導し、CD4陽性T細胞の抗原特異的免疫応答を抑制する.2007
- Author(s)
  中込一之, 土肥眞, 奥西勝秀, 他。
- Organizer
  第47回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2007-05-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590782

1. YAMAMOTO Kazuhiko (80191394)

# of Collaborated Projects: 9 results

# of Collaborated Products: 8 results
2. TANAKA Ryoichi (60272556)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
3. MISAKI Yoshiikata (60219615)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SAWADA Tetsuji (50235470)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SUKO Matsunobu (80107622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHINOHARA Satoshi (90282657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 原田広彰 (40579687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 今村充 (80529157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 當間重人 (50207528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

DOHI Makoto 土肥 眞

Research Projects

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Co-Researchers

アレルギー性気道炎症に対するイソプレノイドの抑制効果についての実験的研究Principal Investigator

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An experimental research on new therapy of bronchial asthma through modulation of dendritic cell functions by IL-10Principal Investigator

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An experimental study on the control of bronchial asthma by a regenerating factor of bronchial epithelial cellsPrincipal Investigator

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[Book] ステロイドハンドブック:呼吸器疾患2007

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[Book] 樹状細胞と呼吸器疾患、Annual Review 呼吸器 20072007

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[Journal Article] アレルギー疾患と免疫異常:気管支喘息2013

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[Journal Article] Prolonged allergen challenge in murine nasal allergic rhinitis : nasal airway remodeling and adaptation of nasal airway responsiveness2007

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Description

DOHI Makoto 土肥眞