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KANAME Shinya  要 伸也

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要 伸也  カナメ シンヤ

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Researcher Number 60224581
Other IDs
Affiliation (Current) 2025: 杏林大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help 2017 – 2023: 杏林大学, 医学部, 教授
2004 – 2006: 東京大学, 医学部附属病院, 客員助教授
2005: 東京大学, 医学部附属病院, 寄附講座教員(客員助教授)
2002 – 2003: Faculty of Medicine, Department of Nephrology and Endocrinology, Research Assciate, 医学部附属病院, 助手
2000 – 2001: 東京大学, 医学部・附属病院, 助手 … More
2000: 東京大学, 医学部・付属病院分院, 助手
1999 – 2000: University of Tokyo School of Medicine (Branch Hospital), The Department of Internal Medicine, Assistant Professor, 医学部・附属病院・分院, 助手
1999 – 2000: 東京大学, 医学部・附属病院分院, 助手
1998: 東京大学, 医学部附属病院分院, 助手
1997: University of Tokyo, School of Medicine (Branch Hospital) , The Fourth Department of Internal Medicine, Assistant Professor, 医学部・附属病院(分), 助手
1997: 東京大学, 医学部・附属病院分院, 助手
1996: 東京大学, 医学部・附属病院・(分), 助手
1991: 東京大学, 医学部・(分), 助手
1990: 東京大学, 医学部(分)第四内科, 助手
1990: 東京大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Kidney internal medicine / Kidney internal medicine / 内科学一般
Except Principal Investigator
Basic Section 53040:Nephrology-related / Kidney internal medicine / Collagenous pathology/Allergology / Kidney internal medicine / 内科学一般 / Circulatory organs internal medicine
Keywords
Principal Investigator
LOX-1 / PDGF / TGF-β / メサンギウム細胞 / oxidative stress / 6腎摘ラット / 5 / 酸化ストレス / 進行性腎障害 / 酸化LDL … More / LTBP / extracellular matrix / glomerular hypertension / glomerulosclerosis / mesangial cells / stretch / 伸展刺激 / puromycin / podocyte / adrenomedullin / アドレノメデュリン / 足細胞 / progressive renal disease / Lox-1 / oxidized LDL / 腎不全 / Dahlラット / TGF-beta / 細胞外基質 / 糸球体高血圧 / 糸球体硬化 / カチオンチャンネル / AVP / パッチクランプ … More
Except Principal Investigator
LOX-1 / 慢性腎臓病 / 炎症 / Hypertension / TGFβ / 酸化ストレス / 糸球体硬化 / 高血圧 / TGFーβ / PCR / エンドセリン / 急性腎障害 / HMGB1 / DAMP / 尿細管間質 / 低酸素 / 慢性炎症 / 敗血症 / マクロファージ / PHD / バイオマーカー / 治療戦略評価 / 新規臨床サブセット / ANCA測定方法 / ANCA測定法 / シクロホスファミド / 治療戦略 / クラスター解析 / ANCA関連血管炎 / adipocytokines / oxidative stress / aldosterone / metabolic syndrome / chronic kidney disease / glomerulosclerosis / proteinuria / podocyte injury / Rho / スタチン / 糸球体上皮細胞 / アディポサイトカイン / アルドステロン / メタボリックシンドローム / 蛋白尿 / 足細胞障害 / Renal Intestitial / Oxidative Stress / Atherosclerosis / Angiotensin II / Renal Damage / transgenic rat / mineralocorticoid / Salt / Nephrosclerosis / Kidney / tie2 / flk-1 / Diahetes / Redox / PRARγ / Dahl Rat / oxidized LDL / 腎間質 / 動脈硬化 / アンジオテンシンII / 腎障害 / VASCULAR ENDOTHELIAL CELLS / OXIDIZED LDL RECEPTOR / GLOMERULOSCLEROSIS / HYPERTENSION / KIDNEY / TGF-β / SHR / Dahlラット / 酸化LDL / 血管内皮細胞 / 酸化LDL受容体 / 腎臓 / tubulo-glomerular feedback / calcium / endothelin / platelet activating factor / transforming growth factor beta (TGF-beta) / mesangial cells / 細胞内Caイオン / Cーkinase / 皮質集合管 / アルギニンーバソプレッシン / 不活性型 / PAF(血小板刺激因子) / レセプタ- / クロライド / エンドセリンーI / ホルモンレセプター / 近位尿細管 / 副甲状腺ホルモン / プロスタグランディン / バゾプレッシン / 尿細管糸球体フィードバック / カルシウム / 血小板活性化因子 / 形質転換成長因子ーβ / メサンギウム細胞 / 分泌極性 / ライソゾ-ム / 腎尿細管細胞 / ビッグエンドセリン / ダウンレギュレ-ション / 高糖(高グルコ-ス) / mRNA / ラット / 尿細管 / 糸球体 Less
  • Research Projects

    (14 results)
  • Research Products

    (3 results)
  • Co-Researchers

    (23 People)
  •  Investigation of pathophysiology of tubulointerstitial inflammation in kidney diseases from the viewpoint of an inflammation trigger, DAMP

    • Principal Investigator
      川上 貴久
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kyorin University
  •  Development of a novel therapy for kidney diseases targeting the hypoxia sensor PHD in macrophages

    • Principal Investigator
      Kawakami Takahisa
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kyorin University
  •  A multitiered study for clinical subtypes, treatments, and biomarkers using inception cohorts of patients with ANCA-associated vasculitis

    • Principal Investigator
      Tsutsumino Michi
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Tokyo Women's Medical University
  •  Glomerular podocyte injury in lifestyle-related disease : elucidation of its mechanism and establishment of novel therapeutic strategy to inhibit proteinuria

    • Principal Investigator
      NAGASE Miki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      The University of Tokyo
  •  Molecular biological analysis of the role of LOX-1 and oxidative stress in the progressive renal diseasesPrincipal Investigator

    • Principal Investigator
      KANAME Shinya
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      The University of Tokyo
  •  The role of LOX-1 and oxidative stress in the progressive renal disease.Principal Investigator

    • Principal Investigator
      KANAME Shinya
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      The University of Tokyo
  •  Role of oxidized LDL/LOX-1 in the development and progression of renal disease.

    • Principal Investigator
      FUJITA Toshiro
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Kidney internal medicine
    • Research Institution
      The University of Tokyo
  •  Molecular Mechanism of the role of oxidized LDL and physical stress in progressive renal diseasePrincipal Investigator

    • Principal Investigator
      KANAME Shinya
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      The University of Tokyo
  •  ROLE OF LOX-1, A NOVEL OXIDIZED LOW-DENSITY LIPOPROTEIN RECEPTOR.IN THE PROGRESSION OF RENAL INJURY

    • Principal Investigator
      NAGASE Miki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      UNIVERSITY OF TOKYO
  •  The molecular mechanism of the effect of mechanical stretch on various factors in glomerular cells.Principal Investigator

    • Principal Investigator
      KANAME Shinya
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      The University of Tokyo School of Medicine (Branch Hospital)
  •  The effect of mechanical stretch on TGF-beta and extracellular matrix expression in glomerular cells.Principal Investigator

    • Principal Investigator
      KANAME Shinya
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      University of Tokyo
  •  ホルモン応答性イオンチャンネル開閉機構とその解析Principal Investigator

    • Principal Investigator
      要 伸也
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  エンドセリンの腎糸球体・尿細管での合成とその作用についての分子生物学的研究

    • Principal Investigator
      内田 俊也
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      The University of Tokyo
  •  Studies on the requlatory mechanisms of renal glomerular and tubular functions.

    • Principal Investigator
      KUROKAWA Kiyoshi
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      内科学一般
    • Research Institution
      Faculty of Medicine, University of Tokyo

All 2020 2005

All Journal Article

  • [Journal Article] JCS 2017 Guideline on Management of Vasculitis Syndrome ― Digest Version ―2020

    • Author(s)
      Isobe, M. Amano, K. Arimura, Y. Ishizu, A. Ito, S. Kaname, S. Takahashi, K. Tanemoto, K. Hasegawa, H. Harigai, M. Fujimoto, S. Miyazaki, T. et.al.
    • Journal Title

      Circ J

      Volume: 84 Issue: 2 Pages: 299-359

    • DOI

      10.1253/circj.CJ-19-0773

    • NAID

      130007789906

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2020-01-24
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07478, KAKENHI-PROJECT-17K09990, KAKENHI-PROJECT-17K10259, KAKENHI-PROJECT-19K08679, KAKENHI-PROJECT-20K07398, KAKENHI-PROJECT-17K09986
  • [Journal Article] Expression and regulation of adrenomedullin in renal glomerular podocytes.2005

    • Author(s)
      Hino M, Nagase M, Kaname S, Shibata S, Nagase T, Oba S, Funaki M, Kobayashi N, Kawachi H, Mundel P, Fujita T
    • Journal Title

      Biochem Biophys Res Com 330

      Pages: 178-185

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590778
  • [Journal Article] Expression and regulation of adrenomedullin in renal glomerular podocytes.2005

    • Author(s)
      Hino M, Nagase M, Kaname S, Shibata S, Nagase T, Oba S, Funaki M, Kobayashi N, Kawachi H, Mundel P, Fujita T
    • Journal Title

      Biochem Biophys Res Com 330 : 178-85, 2005. 330

      Pages: 178-85

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590778
  • 1.  NAGASE Miki (60302733)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  内田 俊也 (50151882)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  Kawakami Takahisa (10722093)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  宮嶋 芳弘
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  KUROKAWA Kiyoshi (30167390)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  TANIGUCHI Shigeo (50188380)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  NAKAO Akihide (10159056)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  NOSAKA Kazuo (70150274)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  WATANABE Tsuyoshi (80158641)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  ANDO Katsuyuki (60184313)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  FUJITA Toshiro (10114125)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  SHIMOSAWA Tatsuo (90231365)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TAKAHASHI Katsutoshi (00292863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  GOTODA Takanari (60322731)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  Tsutsumino Michi (50277141)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  吉良 有二 (90057068)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  関 常司 (30206619)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  高市 憲明 (00175423)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  深川 雅史 (00211516)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  鈴木 慶二 (70124675)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  針谷 正祥 (20238207)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  勝又 康弘 (60349719)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  佐田 憲映 (70423308)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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