• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Miyake Kensuke  三宅 健介

ORCIDConnect your ORCID iD *help
… Alternative Names

MIYAKE Kensuke  三宅 健介

Less
Researcher Number 60229812
Other IDs
Affiliation (Current) 2025: 千葉大学, 未来粘膜ワクチン研究開発シナジー拠点, 特任教授
Affiliation (based on the past Project Information) *help 2001 – 2024: 東京大学, 医科学研究所, 教授
2003 – 2004: 東京大学, 医科学研究所・感染遺伝学分野, 教授
1993 – 2000: 佐賀医科大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Immunology / Biological Sciences / Immunology / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Biological Sciences / Transformative Research Areas, Section (III) / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Pathology, Infection/Immunology, and related fields / Pathological medical chemistry
Except Principal Investigator
内科学一般 … More / Transformative Research Areas, Section (III) / Basic Section 57060:Surgical dentistry-related / Dermatology / Pediatrics / Immunology / Immunology Less
Keywords
Principal Investigator
自然免疫 / Toll様受容体 / Toll-like receptor / RP105 / MD-2 / 病原体 / ロイシンリッチリピート / B細胞 / LPS / MD-1 … More / Lipopolysaccharide / 病原体センサー / 遺伝子クローニング / 免疫学 / innate immunity / ノックアウトマウス / endotoxin / エンドトキシン / マウス / Lipopolyaccharide / leucine-rich repeat / リソソーム / B細胞受容体 / natural antibody / 自然抗体 / Toll like receptor / pathogen / gene cloning / knockout mice / Blymphocytes / 一本鎖核酸 / TLR8 / TLR7 / TLR / 拡張型心筋症 / 病源体センサー / 自然得免疫 / セルソーター / アウトリーチ活動 / 遺伝子改変マウス / 炎症 / Toll-1ike receptor / 自己免疫疾患 / Toll-like Receptor / リポ多糖 / RP105アポトーシス … More
Except Principal Investigator
LPS / MD-2 / TLR4 / CD14 / RP105 / SLE / 自然免疫 / IFN-α / IL-1β / E5531 / LipdIVa / MD-1 / LBP / 自己抗体 / IgG / シェーグレン症候群 / アポトーシス / B細胞 / WF1マウス / B / 恒常性維持 / 自己認識 / 自己分子 / 免疫センサー / TNF-α / Toll 様受容体 8 / ヒトTLR8 Tg/マウスTLR8 KO マウス / TLR8 / モデルマウス / 単球/マクロファージ / Toll様受容体 / 紫外線照射 / トール様受容体 / 膠原病 / Toll-like receptor 3(TLR3) / double-stranded RNA(dsRNA) / febrile seizure / IL-1 / Toll-like receptor / 遺伝子多型 / 2本鎖RNA / Toll-like receptor-3 / 熱性けいれん / cytokine / ligand / bacterial expression / recombinant protein / トランスフェクタント / キメラ蛋白 / ノックアウト / CHO / 変異蛋白 / 融合蛋白 / アイソフォーム / 川崎病 / リコンピナント蛋白 / サイトカイン / リガンド / 大腸菌発現 / リコンビナント蛋白 / Anti-DNA antibody / Apoptosis / Dermatomyositis / Sjogren's syndrome / B cell / apoptosis / ステロイド / 活性化B細胞 / 免疫グロブリン / 抗DNA抗体 / 皮膚筋炎 / TCRレパトリ- / ペプチドモチーフ / クラスII分子 / 変異APC / T細胞クローン / 病原性自己ペプチド / トレランス / MB-1 / 抗原レセプター / シグナル伝達 / ホスファターゼ / 免疫抑制剤 / リン酸化 / 細胞周期 / ストレス / アミノ酸シークエンス / 結合ペプチドモチーフ / 自己ペプチド / 病原性自己反応性T細胞クローン / AαdクラスII分子 / Aβz / APC変異株 / 自己抗原ペプチド / 自己免疫疾患 / F1マウス / BW / クローン化T細胞 / 自己抗原処理・提示 / MHCクラスII分子変異細胞株 Less
  • Research Projects

    (50 results)
  • Research Products

    (179 results)
  • Co-Researchers

    (50 People)
  •  Analyses of the BCR complex that determine B cell survival and proliferationPrincipal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      The University of Tokyo
  •  Molecular bases enabling various BCR responsesPrincipal Investigator

    • Principal Investigator
      Miyake Kensuke
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      The University of Tokyo
  •  Molecular and structural bases enabling self-derived nucleic acid recognition in lysosomesPrincipal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      The University of Tokyo
  •  Self-referential immune perception

    • Principal Investigator
      山崎 晶
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Osaka University
  •  Studying molecular bases of alternative TLR responsesPrincipal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      The University of Tokyo
  •  Studying innate immune responses to nucleoside stressPrincipal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      The University of Tokyo
  •  自然免疫応答と脂質代謝の連携分子基盤の解明Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      The University of Tokyo
  •  Novel therapeutic strategies for Sjogren's syndrome targeting Toll-like receptors.

    • Principal Investigator
      Moriyama Masafumi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Kyushu University
  •  Understanding a mechanism controlling endogenous retrovirus by Toll-like receptorsPrincipal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Pathology, Infection/Immunology, and related fields
    • Research Institution
      The University of Tokyo
  •  Cell and Molecular mechanisms underlying the interaction between the innate immune system and metabolism in lysosomesPrincipal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      2016 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  リソソームでの核酸認識における核酸代謝系の役割についての研究Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2016
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  The role of a transcription factor TFEB in the innate immune systemPrincipal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  The effect of UV irradiation on development of systemic lupus in mouse model

    • Principal Investigator
      SANO SHIGETOSHI
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      Kochi University
  •  Novel regulatory mechanism of TLR7/8 by ssRNAPrincipal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  Molecular basis underlying Toll-like receptor logisticsPrincipal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  The role of innate immunity in Dilated CardiomyopathyPrincipal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokyo
  •  TOLL様受容体の認識機構と包括的活性制御機構の解明Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Homeostatic inflammation: Molecular basis and dysregulationPrincipal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      2009 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Toll like receptors; their endogenous ligands and mechanism regulating their activitiesPrincipal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      2009 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  自然免疫におけるDNA応答とRNA応答の間のバランス制御機構の解明Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  Homeostatic inflammation: Molecular basis and dysregulationArea Organizer

    • Area Organizer
      MIYAKE Kensuke
    • Project Period (FY)
      2009 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      The University of Tokyo
  •  Toll様受容体の様受容体の内因性リガンドへの応答とその調節機構の解明Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Studying mechanisms controlling responsiveness of Toll-like ReceptorsPrincipal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  病原体センサと自己成分との相互作用についての研究Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  Toll-like receptorファミリーの包括的活性制御機構の解明Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Analyses of Toll-like receptors regulating innate antibody response against microbial lipidsPrincipal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  The role of MD-2 in the pathogen recognition

    • Principal Investigator
      AKASHI Sachiko
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  INF-α productivity and Toll-like receptor 3 gene polymorphism in patients with febrile seizure

    • Principal Investigator
      MATSUO Muneaki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Saga University
      佐賀医科大学
  •  Roles for MD molecules in endotoxin recognitionPrincipal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Tollファミリー分子(TLR)によるLPS認識と獲得免疫発動機構の解明Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Tollファミリー分子による病原体認識機構の解明とそれを応用した癌免疫療法の開発Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Toll-like Receptorに会合するMDタンパクの遺伝学的解析Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Analysis of pathogen recognition by TLR4 and RP105 and their application to immunothrapy

    • Principal Investigator
      KIMOTO Masao
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Saga University
      佐賀医科大学
  •  The Function analysis of MD-2 molecule about LPS recognition

    • Principal Investigator
      AKASHI Sachiko
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  Tollファミリー分子による,細菌リポ多糖認識および自己糖脂質との識別機構の解明Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      佐賀医科大学
  •  Tollファミリー分子による細菌リポ多糖認識機構解明とそのがん免疫療法への応用Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      佐賀医科大学
  •  Recognition of Lipopolysaccharide by The Toll Receptor ComplexPrincipal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
      佐賀医科大学
  •  癌免疫療法を目的としてロイシンリッチリピート分子の基礎的解析Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      佐賀医科大学
  •  Analysis of RP105, a novel B cell-associated antigen, in autoimmune diseases

    • Principal Investigator
      NAGASAWA Kohei
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Saga Medical School
  •  ロイシンリッチリピートタンパクによる免疫システム制御機構の解析Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      佐賀医科大学
  •  B細胞表面分子RP105についての個体レベル、分子レベルでの機能解析:会合分子の遺伝子単離とRP105ノックアウトマウスの作製Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      佐賀医科大学
  •  CD40とRPl05経路によるB細胞活性化機構の比較、解析Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      佐賀医科大学
  •  Molecular and Cellular Analysis of a Leucine-rich Repeat Molecule RP105Principal Investigator

    • Principal Investigator
      MIYAKE Kensuke
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Saga Medical School
  •  RP105分子を介するマウスB細胞活性化機構の解析Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      佐賀医科大学
  •  マウスB細胞表面分子RP105のリガンドの検索及びシグナル伝達機構の解析Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      佐賀医科大学
  •  MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析

    • Principal Investigator
      木本 雅夫
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      佐賀医科大学
  •  マウスB細胞のアポトーシスを阻害し、増殖を誘導する細胞表面抗原の遺伝子の単離Principal Investigator

    • Principal Investigator
      三宅 健介
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      佐賀医科大学
  •  MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析

    • Principal Investigator
      木本 雅夫
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      佐賀医科大学
  •  B細胞のシグナル伝達

    • Principal Investigator
      阪口 薫雄
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
      Tottori University
  •  MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析

    • Principal Investigator
      KIMOTO Masao
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      佐賀医科大学

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2004 Other

All Journal Article Presentation Book Patent

  • [Book] medicina2013

    • Author(s)
      柴田 琢磨、三宅 健介
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-24659145
  • [Journal Article] A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages2024

    • Author(s)
      I. Sasaki, Y. Fukuda-Ohta, C. Nakai, N. Wakaki-Nishiyama, C. Okamoto, D. Okuzaki, S. Morita, S. Kaji, Y. Furuta, H. Hemmi, T. Kato, A. Yamamoto, E. Tosuji, SI Saitoh, T. Tanaka, K. Hoshino, S. Fukuda, K. Miyake, E. Kuroda, KJ Ishii, T. Iwawaki, K. Furukawa, T. Kaisho.
    • Journal Title

      Cell Reports

      Volume: 43 Issue: 4 Pages: 113981-113981

    • DOI

      10.1016/j.celrep.2024.113981

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K18222, KAKENHI-PROJECT-23K19487, KAKENHI-PROJECT-22K07006, KAKENHI-PROJECT-22K19424, KAKENHI-PLANNED-22H05184, KAKENHI-PLANNED-22H05187, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23K27421
  • [Journal Article] Extracellular aaRSs drive autoimmune and inflammatory responses in rheumatoid arthritis via the release of cytokines and PAD42023

    • Author(s)
      Kimura A, Takagi T, Thamamongood T, Sakamoto S, Ito T, Seki I, Okamoto M, Aono H, Serada S, Naka T, Imataka H, Miyake K, Ueda T, Miyanokoshi M, Wakasugi K, Iwamoto N, Ohmagari N, Iguchi T, Nitta T, Takayanagi H, Yamashita H, Kaneko H, Tsuchiya H, Fujio K, Handa H, Suzuki H.
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 82 Issue: 9 Pages: 1153-1161

    • DOI

      10.1136/ard-2023-224055

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22KJ1021, KAKENHI-PROJECT-23K06590, KAKENHI-PROJECT-21K07088, KAKENHI-PROJECT-21K18254, KAKENHI-PROJECT-22K19424, KAKENHI-PLANNED-22H05184, KAKENHI-PUBLICLY-22H05559, KAKENHI-PUBLICLY-23H04770, KAKENHI-PROJECT-21H05046, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23K23875, KAKENHI-PROJECT-23K24148
  • [Journal Article] TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction2023

    • Author(s)
      Sakaniwa Kentaro、Fujimura Akiko、Shibata Takuma、Shigematsu Hideki、Ekimoto Toru、Yamamoto Masaki、Ikeguchi Mitsunori、Miyake Kensuke、Ohto Umeharu、Shimizu Toshiyuki
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 164-164

    • DOI

      10.1038/s41467-023-35844-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-23K23820, KAKENHI-PROJECT-22K19424, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23H00366
  • [Journal Article] STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes.2023

    • Author(s)
      Kuchitsu Y, Mukai K, Uematsu R, Takaada Y, Shinojima A, Shindo R, Shoji T, Hamano S, Ogawa E, Sato R, Miyake K, Kato A, Kawaguchi Y, Nishitani-Isa M, Izawa K, Nishikomori R, Yasumi T, Suzuki T, Dohmae N, Uemura T, Barber GN, Arai H, Waguri S, Taguchi T.
    • Journal Title

      Nature Cell Biology

      Volume: 25 Issue: 3 Pages: 453-466

    • DOI

      10.1038/s41556-023-01098-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07104, KAKENHI-PROJECT-21K19498, KAKENHI-PUBLICLY-22H05584, KAKENHI-PROJECT-20H03202, KAKENHI-PROJECT-20H03415, KAKENHI-PROJECT-21K15464, KAKENHI-PROJECT-20H03492, KAKENHI-PUBLICLY-21H00338, KAKENHI-PUBLICLY-22H04631, KAKENHI-PROJECT-22K07829, KAKENHI-PROJECT-22K19424, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-21H04800
  • [Journal Article] The anti‐TLR4 monoclonal antibody Sa15‐21 enhances inflammatory cytokine production in LPS‐stimulated macrophages2023

    • Author(s)
      Chowdhury Sajid Iftekhar、Inui Masanori、Yamazaki Tatsuya、Tomono Susumu、Takagi Hidekazu、Biswas Mrityunjoy、Saitoh Shin‐Ichiroh、Miyake Kensuke、Akashi‐Takamura Sachiko
    • Journal Title

      FEBS Letters

      Volume: - Issue: 9 Pages: 1-15

    • DOI

      10.1002/1873-3468.14619

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-20H03466, KAKENHI-PROJECT-19K08500, KAKENHI-PROJECT-20K11635
  • [Journal Article] Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome2023

    • Author(s)
      Zhang Zhikuan、Shibata Takuma、Fujimura Akiko、Kitaura Jiro、Miyake Kensuke、Ohto Umeharu、Shimizu Toshiyuki
    • Journal Title

      Nature

      Volume: 622 Issue: 7981 Pages: 188-194

    • DOI

      10.1038/s41586-023-06532-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K18211, KAKENHI-PROJECT-22K19424, KAKENHI-PROJECT-22K15046, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23K23820, KAKENHI-PROJECT-23K27637
  • [Journal Article] Aberrant monocytopoiesis drives granuloma development in sarcoidosis2023

    • Author(s)
      Hiranuma Ryosuke、Sato Ryota、Yamaguchi Kiyoshi、Nakamizo Satoshi、Asano Kenichi、Shibata Takuma、Fukui Ryutaro、Furukawa Yoichi、Kabashima Kenji、Miyake Kensuke
    • Journal Title

      International Immunology

      Volume: 36 Issue: 4 Pages: 183-196

    • DOI

      10.1093/intimm/dxad054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K07782, KAKENHI-PROJECT-22K19424, KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-21H04800
  • [Journal Article] Role of the orphan transporter SLC35E1 in the nuclear egress of herpes simplex virus 12022

    • Author(s)
      Fumio Maeda, Akihisa Kato, Kosuke Takeshima, Misato Shibazaki, Ryota Sato, Takuma Shibata, Kensuke Miyake, Hiroko Kozuka-Hata, Masaaki Oyama, Eigo Shimizu, Seiya Imoto, Satoru Miyano, Shungo Adachi, Tohru Natsume, Koh Takeuchi, Yuhei Maruzuru, Naoto Koyanagi, Jun Arii, Yasushi Kawaguchi
    • Journal Title

      Journal of Virology

      Volume: - Issue: 10 Pages: 10-10

    • DOI

      10.1128/jvi.00306-22

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22524, KAKENHI-PROJECT-20K07511, KAKENHI-PROJECT-21K19370, KAKENHI-PROJECT-21K19498, KAKENHI-PROJECT-22K15468, KAKENHI-PLANNED-21H05280, KAKENHI-PLANNED-22H05184, KAKENHI-PUBLICLY-22H05584, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-20H03496, KAKENHI-PROJECT-21K15464, KAKENHI-PROJECT-20H05692, KAKENHI-PROJECT-20H03492, KAKENHI-PUBLICLY-21H00338, KAKENHI-PUBLICLY-21H00417, KAKENHI-WRAPUP-22H04899, KAKENHI-PROJECT-20H03378
  • [Journal Article] Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus2022

    • Author(s)
      Leibler Claire、John Shinu、Elsner Rebecca A.、Thomas Kayla B.、Smita Shuchi、Joachim Stephen、Levack Russell C.、Callahan Derrick J.、Gordon Rachael A.、Bastacky Sheldon、Fukui Ryutaro、Miyake Kensuke、Gingras Sebastien、Nickerson Kevin M.、Shlomchik Mark J.
    • Journal Title

      Nature Immunology

      Volume: 23 Issue: 10 Pages: 1457-1469

    • DOI

      10.1038/s41590-022-01310-2

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05184, KAKENHI-PROJECT-21H04800
  • [Journal Article] Dynamic control of nucleic-acid-sensing Toll-like receptors by the endosomal compartment.2021

    • Author(s)
      Miyake K, Saitoh S-I, Fukui R, Shibata T, Sato R, and Murakami Y.
    • Journal Title

      International Immunology

      Volume: 33 Issue: 12 Pages: 835-840

    • DOI

      10.1093/intimm/dxab037

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-20H04900, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-21K15464, KAKENHI-PROJECT-20H03466
  • [Journal Article] Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors2021

    • Author(s)
      Gavin Amanda L.、Huang Deli、Blane Tanya R.、Thinnes Therese C.、Murakami Yusuke、Fukui Ryutaro、Miyake Kensuke、Nemazee David
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1

    • DOI

      10.1038/s41467-021-26150-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Journal Article] Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages2021

    • Author(s)
      Liu Kaiwen、Sato Ryota、Shibata Takuma、Hiranuma Ryosuke、Reuter Tatjana、Fukui Ryutaro、Zhang Yun、Ichinohe Takeshi、Ozawa Manabu、Yoshida Nobuaki、Latz Eicke、Miyake Kensuke
    • Journal Title

      International Immunology

      Volume: 33 Issue: 9 Pages: 479-490

    • DOI

      10.1093/intimm/dxab033

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03162, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-20H03491, KAKENHI-PROJECT-21K15464, KAKENHI-PROJECT-16H06276
  • [Journal Article] The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages2020

    • Author(s)
      Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K.
    • Journal Title

      Int Immunol

      Volume: 32 Issue: 12 Pages: 785-798

    • DOI

      10.1093/intimm/dxaa055

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21612, KAKENHI-PUBLICLY-18H04856, KAKENHI-PUBLICLY-20H04900, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-20H03466, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-18K07169, KAKENHI-PROJECT-19K16685, KAKENHI-PROJECT-19H03451, KAKENHI-PROJECT-19K22635
  • [Journal Article] Phospholipase A2 from bee venom increases poly(I:C)-induced activation in human keratinocytes2020

    • Author(s)
      Nakashima Akina、Tomono Susumu、Yamazaki Tatsuya、Inui Masanori、Morita Naoko、Ichimonji Isao、Takagi Hidekazu、Nagaoka Fumiaki、Matsumoto Misako、Ito Yasuhiko、Yanagishita Takeshi、Miyake Kensuke、Watanabe Daisuke、Akashi-Takamura Sachiko
    • Journal Title

      International Immunology

      Volume: - Issue: 6 Pages: 371-383

    • DOI

      10.1093/intimm/dxaa005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08874, KAKENHI-PROJECT-19K08500, KAKENHI-PROJECT-16H05898, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-19K22635
  • [Journal Article] Endolysosomal compartments as platforms for orchestrating innate immune and metabolic sensors2019

    • Author(s)
      Miyake Kensuke、Saitoh Shin‐ichiroh、Sato Ryota、Shibata Takuma、Fukui Ryutaro、Murakami Yusuke
    • Journal Title

      Journal of Leukocyte Biology

      Volume: 106 Issue: 4 Pages: 853-862

    • DOI

      10.1002/jlb.mr0119-020r

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16685, KAKENHI-PUBLICLY-18H04666, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-19H03451, KAKENHI-PROJECT-19K22635
  • [Journal Article] Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs.2019

    • Author(s)
      Furusho K, Shibata T, Sato R, Fukui R, Motoi Y, Zhang Y, Saitoh SI, Ichinohe T, Moriyama M, Nakamura S, Miyake, K.
    • Journal Title

      International immunology.

      Volume: 31 Issue: 3 Pages: 167-173

    • DOI

      10.1093/intimm/dxy075

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04856, KAKENHI-PROJECT-16H05193, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K22723, KAKENHI-PUBLICLY-18H04666, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-19H00976, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-16K08827, KAKENHI-PROJECT-19K22635
  • [Journal Article] ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus2019

    • Author(s)
      Saitoh Shin-Ichiroh、Saitoh Yoshiko Mori、Kontani Kenji、Sato Katsuaki、Miyake Kensuke
    • Journal Title

      International Immunology

      Volume: 31 Issue: 4 Pages: 225-237

    • DOI

      10.1093/intimm/dxy084

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07351, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16H06276
  • [Journal Article] Mechanisms controlling nucleic acid-sensing Toll-like receptors2018

    • Author(s)
      Miyake Kensuke、Shibata Takuma、Ohto Umeharu、Shimizu Toshiyuki、Saitoh Shin-Ichiroh、Fukui Ryutaro、Murakami Yusuke
    • Journal Title

      International Immunology

      Volume: 30 Issue: 2 Pages: 43-51

    • DOI

      10.1093/intimm/dxy016

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293083, KAKENHI-PUBLICLY-17H05991, KAKENHI-PROJECT-16K15253, KAKENHI-PUBLICLY-18H04666, KAKENHI-PUBLICLY-18H04856, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16K08827
  • [Journal Article] Biallelic Variants in CNPY3 , Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy2018

    • Author(s)
      Mutoh Hiroki、Kato Mitsuhiro、Akita Tenpei、Shibata Takuma、Wakamoto Hiroyuki、Ikeda Hiroko、Kitaura Hiroki、Aoto Kazushi、Nakashima Mitsuko、Wang Tianying、Ohba Chihiro、Miyatake Satoko、Miyake Noriko、Kakita Akiyoshi、Miyake Kensuke、Fukuda Atsuo、Matsumoto Naomichi、Saitsu Hirotomo
    • Journal Title

      The American Journal of Human Genetics

      Volume: 102 Issue: 2 Pages: 321-329

    • DOI

      10.1016/j.ajhg.2018.01.004

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08513, KAKENHI-PROJECT-17K08534, KAKENHI-PROJECT-17K19682, KAKENHI-INTERNATIONAL-15K21731, KAKENHI-ORGANIZER-15H05871, KAKENHI-PLANNED-15H05872, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H05160, KAKENHI-PROJECT-17H04025, KAKENHI-PROJECT-15K06751, KAKENHI-PROJECT-17K00918, KAKENHI-PROJECT-17K10888, KAKENHI-PROJECT-16H06276
  • [Journal Article] Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA2018

    • Author(s)
      Fukui Ryutaro、Yamamoto Chikako、Matsumoto Fumi、Onji Masahiro、Shibata Takuma、Murakami Yusuke、Kanno Atsuo、Hayashi Takuto、Tanimura Natsuko、Yoshida Nobuaki、Miyake Kensuke
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 1491-1491

    • DOI

      10.3389/fimmu.2018.01491

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07169, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08827
  • [Journal Article] Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.2018

    • Author(s)
      Sato R, Kato A, Chimura T, Saitoh SI, Shibata T, Murakami Y, Fukui R, Liu K, Zhang Y, Arii J, Sun-Wada GH, Wada Y, Ikenoue T, Barber GN, Manabe T, Kawaguchi Y, Miyake K.
    • Journal Title

      Nat Immunol.

      Volume: 19 Issue: 10 Pages: 1071-1082

    • DOI

      10.1038/s41590-018-0203-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-17K19549, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PUBLICLY-18H04666, KAKENHI-PUBLICLY-18H04856, KAKENHI-PUBLICLY-18H04968, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-16K08827, KAKENHI-ORGANIZER-15H05935
  • [Journal Article] Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication.2018

    • Author(s)
      Maruzuru Y, Ichinohe T, Sato R, Miyake K, Okano T, Suzuki T, Koshiba T, Koyanagi N, Tsuda S, Watanabe M, Arii J, Kato A, Kawaguchi Y.
    • Journal Title

      Cell Host Microbe.

      Volume: 23 Issue: 2 Pages: 254-265

    • DOI

      10.1016/j.chom.2017.12.014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-16K15280, KAKENHI-PROJECT-26293102, KAKENHI-PROJECT-26713017, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-15H04730, KAKENHI-PROJECT-16H05193, KAKENHI-PROJECT-15J09601, KAKENHI-PROJECT-26460548, KAKENHI-PROJECT-15K15138, KAKENHI-PROJECT-17K19549, KAKENHI-PUBLICLY-18H04863, KAKENHI-PUBLICLY-18H04968, KAKENHI-PROJECT-17H03667, KAKENHI-PROJECT-17K19561, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-16H06276
  • [Journal Article] Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease.2017

    • Author(s)
      Furukawa S, Moriyama M, Miyake K, Nakashima H, Tanaka A, Maehara T, Iizuka-Koga M, Tsuboi H, Hayashida JN, Ishiguro N, Yamauchi M, Sumida T, Nakamura S
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 42413-42413

    • DOI

      10.1038/srep42413

    • NAID

      120007135019

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-15K11075, KAKENHI-PROJECT-17K18092, KAKENHI-PROJECT-26293430, KAKENHI-PROJECT-16J07704, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-17H04671
  • [Journal Article] Emerging roles of the processing of nucleic acids and Toll-like receptors in innate immune responses to nucleic acids2017

    • Author(s)
      Miyake K, Shibata T, Ohto U, Shimizu T
    • Journal Title

      J Leukoc Biol

      Volume: 101 Issue: 1 Pages: 135-142

    • DOI

      10.1189/jlb.4mr0316-108r

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16K08827
  • [Journal Article] Selectivity of Human TLR9 for Double CpG Motifs and Implications for the Recognition of Genomic DNA2017

    • Author(s)
      Pohar J, Yamamoto C, Fukui R, Cajnko MM, Miyake K, Jerala R, Bencina M
    • Journal Title

      J Immunol

      Volume: 198 Issue: 5 Pages: 2093-2104

    • DOI

      10.4049/jimmunol.1600757

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17K19548
  • [Journal Article] The protective effect of the anti-Toll-like receptor 9 antibody against acute cytokine storm caused by immunostimulatory DNA2017

    • Author(s)
      Murakami Y, Fukui R, Motoi Y, Shibata T, Saitoh SI, Sato R, Miyake K.
    • Journal Title

      Scientific Report

      Volume: 7 Issue: 1 Pages: 44042-44054

    • DOI

      10.1038/srep44042

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-16K15253, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16K08827
  • [Journal Article] Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos2017

    • Author(s)
      Oka M, Hashimoto K, Yamaguchi Y, Saitoh SI, Sugiura Y, Motoi Y, Honda K, Kikko Y, Ohata S, Suematsu M, Miura M, Miyake K, Katada T and Kontani K
    • Journal Title

      J Cell Sci

      Volume: 130 Issue: 20 Pages: 3568-3577

    • DOI

      10.1242/jcs.200519

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07351, KAKENHI-PROJECT-26291038, KAKENHI-PROJECT-26293083, KAKENHI-PLANNED-26110005, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H05127, KAKENHI-PROJECT-17H03981, KAKENHI-PROJECT-16H06145, KAKENHI-PROJECT-16K15253
  • [Journal Article] Requirement of glycosylation machinery in TLR responses revealed by CRISPR/Cas9 screening2017

    • Author(s)
      Sato Ryota、Shibata Takuma、Tanaka Yu、Kato Chiharu、Yamaguchi Kiyoshi、Furukawa Yoichi、Shimizu Eigo、Yamaguchi Rui、Imoto Seiya、Miyano Satoru、Miyake Kensuke
    • Journal Title

      International Immunology

      Volume: 29 Issue: 8 Pages: 347-355

    • DOI

      10.1093/intimm/dxx044

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17H03575, KAKENHI-PUBLICLY-16H01569, KAKENHI-PROJECT-16K08827, KAKENHI-PROJECT-17K07214
  • [Journal Article] TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells2017

    • Author(s)
      Saitoh SI, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K and Miyake K
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 1592-1592

    • DOI

      10.1038/s41467-017-01687-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07351, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-26291038, KAKENHI-PROJECT-26293083, KAKENHI-PLANNED-16H06578, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H05193, KAKENHI-PROJECT-17H03981, KAKENHI-PROJECT-16K15253, KAKENHI-PROJECT-16K08827
  • [Journal Article] Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8.2016

    • Author(s)
      Tanji, H., Ohto, U., Motoi, Y., Shibata, T., Miyake, K., & Shimizu, T.
    • Journal Title

      Proc. Natl. Acad. Sci. U S A

      Volume: 113 Issue: 11 Pages: 3012-3017

    • DOI

      10.1073/pnas.1516000113

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-15J12485, KAKENHI-PROJECT-16K08827
  • [Journal Article] Type I IFN Contributes to the Phenotype of Unc93b1D34A/D34A Mice by Regulating TLR7 Expression in B Cells and Dendritic Cells2016

    • Author(s)
      Fukui R, Kanno A, Miyake K
    • Journal Title

      J Immunol

      Volume: 196 Issue: 1 Pages: 416-427

    • DOI

      10.4049/jimmunol.1500071

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-16H02629
  • [Journal Article] Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology2016

    • Author(s)
      Pelka K, Shibata T, Miyake K, Latz E
    • Journal Title

      Immunol Rev

      Volume: 269 Issue: 1 Pages: 60-75

    • DOI

      10.1111/imr.12375

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Journal Article] Guanosine and its modified derivatives are endogenous ligands for TLR72016

    • Author(s)
      Shibata T, Ohto U, Nomura S, Kibata K, Motoi Y, Zhang Y, Murakami Y, Fukui R, Ishimoto T, Sano S, Ito T, Shimizu T, Miyake K.
    • Journal Title

      Int Immunol

      Volume: - Issue: 5 Pages: 211-222

    • DOI

      10.1093/intimm/dxv062

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K15148, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16H02629, KAKENHI-PROJECT-16K08827
  • [Journal Article] Crystal structure of NOD2 and its implications in human disease.2016

    • Author(s)
      Maekawa S, Ohto U, Shibata T, Miyake K, Shimizu T
    • Journal Title

      Nat Commun

      Volume: 7 Issue: 1 Pages: 11813-11813

    • DOI

      10.1038/ncomms11813

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471
  • [Journal Article] Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling2016

    • Author(s)
      Honda S, Sato K, Totsuka N, Fujiyama S, Fujimoto M, Miyake K, Nakahashi-Oda C, Tahara-Hanaoka S, Shibuya K, Shibuya A
    • Journal Title

      Nat Commun

      Volume: 7 Issue: 1 Pages: 1-10

    • DOI

      10.1038/ncomms11498

    • NAID

      120007135503

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01365, KAKENHI-PROJECT-16H06387, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H05169, KAKENHI-PROJECT-14J00713, KAKENHI-PROJECT-26293383, KAKENHI-PROJECT-15K15319, KAKENHI-PROJECT-16K14629, KAKENHI-PROJECT-16K15455, KAKENHI-PROJECT-15H04862, KAKENHI-PROJECT-16H05350
  • [Journal Article] Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA2016

    • Author(s)
      Zhang Z, Ohto U, Shibata T, Krayukhina E, Taoka M, Yamauchi Y, Tanji H, Isobe T, Uchiyama S, Miyake K, Shimizu T
    • Journal Title

      Immunity

      Volume: 45 Issue: 4 Pages: 737-748

    • DOI

      10.1016/j.immuni.2016.09.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-15J12485, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-16K08827
  • [Journal Article] Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes2015

    • Author(s)
      Li X, Saitoh S, Shibata T, Tanimura N, Fukui R, Miyake K.
    • Journal Title

      International immunology

      Volume: 27 Issue: 2 Pages: 83-94

    • DOI

      10.1093/intimm/dxu086

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13J40043, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083
  • [Journal Article] DNase II-dependent DNA digestion is required for DNA sensing by TLR92015

    • Author(s)
      Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh SI, Ohto U, Shimizu T, Barber GN, *Miyake K
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 5853-5853

    • DOI

      10.1038/ncomms6853

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26713011, KAKENHI-PROJECT-25291010
  • [Journal Article] Toll-like receptor 8 senses degradation products of single-stranded RNA.2015

    • Author(s)
      Tanji H, Ohto U, Shibata T, Taoka M, Yamauchi Y, Isobe T, Miyake K,
    • Journal Title

      Nat Struct Mol Biol.

      Volume: 22 Issue: 2 Pages: 109-115

    • DOI

      10.1038/nsmb.2943

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25291010, KAKENHI-PROJECT-25650029, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-15J12485
  • [Journal Article] Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.2015

    • Author(s)
      Ohto, U., Shibata, T., Tanji, H., Krayukhina, E., Uchiyama, S., Miyake, K., and Shimizu, T.
    • Journal Title

      Nature

      Volume: 520 Issue: 7549 Pages: 702-705

    • DOI

      10.1038/nature14138

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-25121722, KAKENHI-PUBLICLY-26102530, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25291010
  • [Journal Article] Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases2015

    • Author(s)
      Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, Saitoh S, Miyake K.
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 6119-6119

    • DOI

      10.1038/ncomms7119

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-13J40043, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26461597, KAKENHI-PROJECT-25291010
  • [Journal Article] Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses.2015

    • Author(s)
      Nundel K, Green NM, Shaffer AL, Moody KL, Busto P, Eilat D, Miyake K, Oropallo MA, Cancro MP, Marshak-Rothstein A
    • Journal Title

      J Immunol.

      Volume: 194 Issue: 6 Pages: 2504-2512

    • DOI

      10.4049/jimmunol.1402425

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25253032
  • [Journal Article] Lipopeptides are signaled by Toll-like receptor 1, 2, and 6 in endolysosomes2014

    • Author(s)
      Motoi Y, Shibata T, Takahashi K, Kanno A, Murakami Y, Xiaobing L, Kasahara T, *Miyake K
    • Journal Title

      Int Immunol

      Volume: 26 Issue: 10 Pages: 563-573

    • DOI

      10.1093/intimm/dxu054

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25253032
  • [Journal Article] UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 52014

    • Author(s)
      Huh JW, Shibata T, Hwang M, Kwon EH, Jang MS, Fukui R, Kanno K, Jung DJ, Jang MH, Miyake K, and Kim YM
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 111 Issue: 19 Pages: 7072-7077

    • DOI

      10.1073/pnas.1322838111

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-25860354
  • [Journal Article] Roles of the Cleaved N-Terminal TLR3 Fragment and Cell Surface TLR3 in Double-Stranded RNA Sensing2014

    • Author(s)
      Murakami Y, Fukui R, Motoi Y, Kanno A, Shibata T, Tanimura N, Saitoh SI, *Miyake K
    • Journal Title

      J Immunol

      Volume: 193 Pages: 5208-5217

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25253032
  • [Journal Article] Endocytosis-free DNA sensing by cell surface TLR9 in neutrophils: Rapid defense with autoimmune risks2013

    • Author(s)
      Miyake K, Onji M
    • Journal Title

      Eur J Immunol

      Volume: 43 Issue: 8 Pages: 2006-2009

    • DOI

      10.1002/eji.201343882

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-25253032
  • [Journal Article] Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in intramolecular disulfide bond, proteolytic cleavage, and RNA-sensing2013

    • Author(s)
      Kanno A, Yamamoto C, Onji M, Fukui R, Saitoh SI, Motoi Y, Shibata T, Matsumoto F, Muta T, Miyake K
    • Journal Title

      Int Immunol.

      Volume: 25 Issue: 7 Pages: 413-422

    • DOI

      10.1093/intimm/dxt007

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117004, KAKENHI-PROJECT-21390088, KAKENHI-PUBLICLY-24117706, KAKENHI-PROJECT-24390076, KAKENHI-PROJECT-24659145, KAKENHI-PROJECT-25670189, KAKENHI-PLANNED-21117002
  • [Journal Article] The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of TLR4/MD2 complex at the plasma membrane2013

    • Author(s)
      Tanimura N, Saitoh S, Ohto U, Akashi-Takamura A, Fujimoto Y, Fukase K, Shimizu T, Miyake K
    • Journal Title

      Int. Immunol.

      Volume: 26 Issue: 6 Pages: 307-314

    • DOI

      10.1093/intimm/dxt071

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23241074, KAKENHI-PROJECT-23590564, KAKENHI-PUBLICLY-24117706, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083
  • [Journal Article] Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A2013

    • Author(s)
      Yamakawa N, Ohto U, Akashi-Takamura S, Takahashi K, Saitoh SI, Tanimura N, Suganami T, Ogawa Y, Shibata T, Shimizu T, Miyake K
    • Journal Title

      Int Immunol.

      Volume: 25 Pages: 45-52

    • Data Source
      KAKENHI-PLANNED-21117002
  • [Journal Article] An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing2013

    • Author(s)
      Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K
    • Journal Title

      Nat. Commun.

      Volume: 4 Issue: 1 Pages: 1949-1949

    • DOI

      10.1038/ncomms2949

    • NAID

      120005359107

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23229004, KAKENHI-PUBLICLY-24117706, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-25860353
  • [Journal Article] Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands2013

    • Author(s)
      Tanji H, Ohto U, Shibata T, Miyake K, Shimizu T
    • Journal Title

      Science

      Volume: 339 Issue: 6126 Pages: 1426-1429

    • DOI

      10.1126/science.1229159

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23770106, KAKENHI-PROJECT-24659145, KAKENHI-PROJECT-25291010, KAKENHI-PUBLICLY-23121510
  • [Journal Article] Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-22012

    • Author(s)
      Ohto U, Fukase K, Miyake K, Shimizu T
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 109 Issue: 19 Pages: 7421-7426

    • DOI

      10.1073/pnas.1201193109

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23241074, KAKENHI-PLANNED-23116007, KAKENHI-PUBLICLY-23121510
  • [Journal Article] Structural analyses of human Toll-like receptor polymorphisms D299G and T399I2012

    • Author(s)
      Ohto U, Yamakawa N, Akashi-Takamura S, Miyake K, Shimizu T
    • Journal Title

      J Biol Chem.

      Volume: 287 Issue: 48 Pages: 40611-40617

    • DOI

      10.1074/jbc.m112.404608

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-22370045, KAKENHI-PROJECT-23590564, KAKENHI-PUBLICLY-23121510
  • [Journal Article] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012

    • Author(s)
      Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K
    • Journal Title

      Int Immunol.

      Volume: 24 Issue: 10 Pages: 613-623

    • DOI

      10.1093/intimm/dxs068

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-23790526, KAKENHI-PROJECT-24659145, KAKENHI-PROJECT-24790463
  • [Journal Article] Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeoatasis.2011

    • Author(s)
      Hirai M, Kadowaki N, Kitawaki T, Fujita H, Takaori-Kondo A, Fukui R, Miyake K, Maeda T, Kamihira S, Miyachi Y, Uchiyama T.
    • Journal Title

      BLOOD

      Volume: 117 Pages: 500-509

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659118
  • [Journal Article] Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis.2011

    • Author(s)
      Hirai M, Kadowaki N, Kitawaki T, Fujita H, Takaori-Kondo A, Fukui R, Miyake K, Maeda T, Kamihira S, Miyachi Y, Uchiyama T.
    • Journal Title

      BLOOD

      Volume: 117 Pages: 500-509

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Journal Article] Novel dimer organization of the TLR family as revealed by the crystal structures of mouse and human RP105/MD-1 complex2011

    • Author(s)
      Ohto U, Miyake K, Shimizu T
    • Journal Title

      J.Mol.Biol.

      Volume: 413 Issue: 4 Pages: 815-825

    • DOI

      10.1016/j.jmb.2011.09.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21117002, KAKENHI-PLANNED-23116007, KAKENHI-PUBLICLY-23121510
  • [Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9-trafficking2011

    • Author(s)
      Fukui R, Saitoh S-I, Kanno A, Onji M, Shibata T, Ito A, Onji M, Matsumoto M, Akira S, Yoshida N, Miyake K
    • Journal Title

      Immunity

      Volume: 35 Pages: 69-81

    • Data Source
      KAKENHI-PLANNED-21117002
  • [Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating TLR7- and TLR9-trafficking.2011

    • Author(s)
      Fukui R, Saitoh S-I, Kanno A, Onji M, Shibata T, Ito A, Onji M, Matsumoto M, Akira S, Yoshida N, Miyake K.
    • Journal Title

      Immunity in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390140
  • [Journal Article] Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes2011

    • Author(s)
      Shibata T, Motoi Y, Tanimura N, Yamakawa N, Akashi-Takamura S, Miyake, K
    • Journal Title

      Int.Immunol.

      Volume: 23 Issue: 8 Pages: 503-510

    • DOI

      10.1093/intimm/dxr044

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21117002, KAKENHI-PUBLICLY-22117505, KAKENHI-PROJECT-23590564
  • [Journal Article] Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes.2011

    • Author(s)
      Shibata T, Motoi Y, Tanimura N, Yamakawa N, Akashi-Takamura S, Miyake, K
    • Journal Title

      Int.Immunol. in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390140
  • [Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking2011

    • Author(s)
      Fukui R
    • Journal Title

      Immunity

      Volume: 35 Issue: 1 Pages: 69-81

    • DOI

      10.1016/j.immuni.2011.05.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19059010, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-21390298, KAKENHI-PROJECT-22500286, KAKENHI-PROJECT-22659097, KAKENHI-PROJECT-22790454, KAKENHI-PUBLICLY-23118520
  • [Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing2009

    • Author(s)
      Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, *^Miyake K.
    • Journal Title

      J.Exp.Med 206

      Pages: 1339-1350

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20060007
  • [Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA- but against RNA-sensing2009

    • Author(s)
      Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, *Miyake K
    • Journal Title

      The Journal of Experimental Medicine 206

      Pages: 1339-1350

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390140
  • [Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA- but against RNA-sensing2009

    • Author(s)
      Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, Miyake K
    • Journal Title

      The Journal of Experimental Medicine 206

      Pages: 1339-1350

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659118
  • [Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing2009

    • Author(s)
      Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, and Miyake K
    • Journal Title

      J. Exp. Med.

      Volume: 206 Pages: 1339-1350

    • Data Source
      KAKENHI-PLANNED-21117002
  • [Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA- but against RNA-sensing.2009

    • Author(s)
      Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, *Miyake K.
    • Journal Title

      J.Exp.Med. in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390140
  • [Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing.2009

    • Author(s)
      Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, Miyake K.
    • Journal Title

      J.Exp.Med

      Volume: 206 Pages: 1339-1350

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing2009

    • Author(s)
      Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, *^Miyake K.
    • Journal Title

      J.Exp.Med. 206

      Pages: 1339-1350

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21022017
  • [Journal Article] Cathepsins are required for Toll-like receptor 9 responses.2008

    • Author(s)
      Matsumoto F, Saitoh S, Fukui R, Kobayashi T, Tanimura N, Konno K, Kusumoto Y, Akashi-Takamura S, *Miyake K.
    • Journal Title

      Biochem Biophys Res Commun. 367

      Pages: 693-699

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390140
  • [Journal Article] Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/1pr mice2008

    • Author(s)
      Kobayashi, T., K.Takahashi, Y.Nagai, T.Shibata, M.Otani, S.Izui, S.Akira, Y.Gotoh, H.Kiyono, K.Miyake
    • Journal Title

      International Immunology 20

      Pages: 881-891

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390140
  • [Journal Article] Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice2008

    • Author(s)
      Kobayashi, T., K. Takahashi, Y. Nagai, T. Shibata, M. Otani, S. Izui, S. Akira, Y. Gotoh, H. Kiyono, and K. Miyake.
    • Journal Title

      Int. Immunol 20

      Pages: 881-891

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20060007
  • [Journal Article] A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors2008

    • Author(s)
      Kiyokawa T, Akashi-Takamura S, Shibata T, Matsumoto F, Nishitani C, Kuroki Y, Seto Y, Miyake K.
    • Journal Title

      International Immunology 20

      Pages: 1407-1415

    • NAID

      10024357741

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390140
  • [Journal Article] Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling.2008

    • Author(s)
      Tanimura N, Saitoh S, Matsumoto F, Akashi-Takamura S, *Miyake K.
    • Journal Title

      Biochem Biophys Res Commun. 368

      Pages: 94-99

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390140
  • [Journal Article] A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors2008

    • Author(s)
      Kiyokawa T, Akashi-Takamura S, S hibata T, Matsumoto F, Nishitani C, Kuroki Y, Seto Y and Miyake K.
    • Journal Title

      Int. Immunol. 20

      Pages: 1407-1415

    • NAID

      10024357741

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19041024
  • [Journal Article] Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.2008

    • Author(s)
      Kobayshi, T., K. Takahashi, Y.Nagai, T. Shibata, M. Otani, S. Izui, S. Akira, Y. Gotoh, H. Kiyono, and K. Miyake.
    • Journal Title

      Int. Immunol. 20

      Pages: 881-891

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20659074
  • [Journal Article] A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors.2008

    • Author(s)
      Kiyokawa T, Akashi-Takamura S, Shibata T, Matsumoto F, Nishitani C, Kuroki Y, Seto Y, *Miyake K.
    • Journal Title

      Int.Immunol. 20

      Pages: 1407-1415

    • NAID

      10024357741

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390140
  • [Journal Article] Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.2008

    • Author(s)
      Kobayashi, T., K.Takahashi, Y.Nagai, T.Shibata, M.Otani, S.Izui, S.Akira, Y.Gotoh, H.Kiyono, *Miyake K
    • Journal Title

      Int.Immunol. 20

      Pages: 881-891

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390140
  • [Journal Article] Endotoxin recognition molecules MD-2 and toll-like receptor 4 as potential targets for therapeutic intervention of endotoxin shock.2004

    • Author(s)
      Miyake K.
    • Journal Title

      Curr Drug Targets Inflamm Allergy 3

      Pages: 291-297

    • Data Source
      KAKENHI-PROJECT-16390142
  • [Journal Article] Endotoxin recognition molecules, Toll-like receptor 4-MD-2.2004

    • Author(s)
      Miyake K.
    • Journal Title

      Semin Immunol. 16

      Pages: 11-16

    • Data Source
      KAKENHI-PROJECT-14021012
  • [Journal Article] Endotoxin recognition molecules MD-2 and toll-like receptor 4 as potential targets for therapeutic intervention of endotoxin shock.2004

    • Author(s)
      Miyake K.
    • Journal Title

      Curr Drug Targets Inflamm Allergy. 3

      Pages: 291-297

    • Data Source
      KAKENHI-PROJECT-14021012
  • [Journal Article] Endotoxin recognition molecules, Toll-like receptor 4-MD-2.2004

    • Author(s)
      Miyake K.
    • Journal Title

      Semin Immunol. 16

      Pages: 11-16

    • Data Source
      KAKENHI-PROJECT-16390142
  • [Patent] 炎症性疾患の予防又は治療剤2013

    • Inventor(s)
      三宅健介、菅野敦夫、恩地正浩、本井祐二
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-089575
    • Filing Date
      2013-04-22
    • Data Source
      KAKENHI-ORGANIZER-21117001
  • [Patent] 炎症性疾患の予防又は治療剤2013

    • Inventor(s)
      三宅健介、菅野敦夫、恩地正浩、本井祐二
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-089575
    • Filing Date
      2013-04-22
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Patent] Unc93B1遺伝子改変マウスの確立とその応用2010

    • Inventor(s)
      三宅健介、斎藤伸一郎、福井竜太郎
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2010-08-10
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20390140
  • [Presentation] Immune disorders due to lysosomal nucleic acid stress2023

    • Author(s)
      三宅 健介
    • Organizer
      The 2nd International Symposium of Clinical Immunology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19424
  • [Presentation] Immune disorders due to lysosomal nucleic acid stress2023

    • Author(s)
      三宅 健介
    • Organizer
      The 2nd International Symposium of Clinical Immunology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05184
  • [Presentation] リソソーム核酸ストレスと疾患2023

    • Author(s)
      三宅 健介
    • Organizer
      日本外科代謝栄養学会第60回学術集会
    • Invited
    • Data Source
      KAKENHI-PLANNED-22H05184
  • [Presentation] リソソーム核酸ストレスと疾患2023

    • Author(s)
      三宅健介
    • Organizer
      日本外科代謝栄養学会第60回学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Presentation] Lysosomal nucleic acid stress diseases2023

    • Author(s)
      三宅 健介
    • Organizer
      JSICR/MMCB 2023 Joint Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05184
  • [Presentation] リソソーム核酸ストレスと疾患2023

    • Author(s)
      三宅 健介
    • Organizer
      日本外科代謝栄養学会第60回学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19424
  • [Presentation] リソソーム核酸ストレスと疾患2023

    • Author(s)
      三宅健介
    • Organizer
      第42回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Presentation] Immune disorders due to lysosomal nucleic acid stress2023

    • Author(s)
      三宅健介
    • Organizer
      The 2nd International Symposium of Clinical Immunology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Presentation] リソソーム核酸ストレスと疾患2023

    • Author(s)
      三宅 健介
    • Organizer
      第42回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PLANNED-22H05184
  • [Presentation] Lysosomal nucleic acid stress diseases2023

    • Author(s)
      三宅健介
    • Organizer
      JSICR/MMCB 2023 Joint Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Presentation] リソソーム核酸ストレスと疾患2023

    • Author(s)
      三宅 健介
    • Organizer
      第42回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19424
  • [Presentation] Lysosomal nucleic acid stress diseases2023

    • Author(s)
      三宅 健介
    • Organizer
      JSICR/MMCB 2023 Joint Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19424
  • [Presentation] リソソーム核酸ストレスに対するマクロファージ応答によって誘導される疾患2022

    • Author(s)
      三宅 健介
    • Organizer
      第42回阿蘇シンポジウム
    • Invited
    • Data Source
      KAKENHI-PLANNED-22H05184
  • [Presentation] Diseases due to lysosomal nucleic acid stress2022

    • Author(s)
      Kensuke Miyake
    • Organizer
      Nucleic acid immunity meeting 2022
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05184
  • [Presentation] Immune disorders due to lysosomal nucleic acid stress2022

    • Author(s)
      Kensuke Miyake
    • Organizer
      The Japanese-German Immunology Workshop
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Presentation] マクロファージのリソソーム核酸ストレス応答によって誘導される疾患2022

    • Author(s)
      三宅 健介
    • Organizer
      第76回日本口腔外科学会学術集会
    • Invited
    • Data Source
      KAKENHI-PLANNED-22H05184
  • [Presentation] リソソーム核酸ストレスに対するマクロファージ応答によって誘導される疾患2022

    • Author(s)
      三宅 健介
    • Organizer
      第42回阿蘇シンポ ジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Presentation] マクロファージのリソソーム核酸ストレス応答によって誘導される疾患2022

    • Author(s)
      三宅 健介
    • Organizer
      第76回日本口腔外科学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Presentation] Immune disorders due to lysosomal nucleic acid stress2022

    • Author(s)
      Kensuke Miyake
    • Organizer
      The Japanese-German Immunology Workshop
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05184
  • [Presentation] Diseases due to lysosomal nucleic acid stress2022

    • Author(s)
      Kensuke Miyake
    • Organizer
      Nucleic acid immunity meeting 2022
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Presentation] RNA metabolism and RNA-sensing in the endosomal compartment2021

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 16th meeting of the international endotoxin and innate immunity society
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Presentation] RNA metabolism and RNA-sensing in the endosomal compartment2021

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 27th international symposium on molecular cell biology of macrophages
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Presentation] 核酸に対する自然免疫応答と炎症性疾患2021

    • Author(s)
      三宅健介
    • Organizer
      医薬品研究開発にかかる発表会・セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K22635
  • [Presentation] 核酸特異的Toll様受容体の活性制御機構とその破綻によるヒト疾患2021

    • Author(s)
      三宅健介
    • Organizer
      第6回ゲノム創薬・創発フォーラム
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Presentation] 核酸に対する自然免疫応答と炎症性疾患2021

    • Author(s)
      三宅 健介
    • Organizer
      医薬品研究開発にかかる発表会・セミナー (富山県薬事総合開発研究センター)
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Presentation] Histiocytosis due to lysosomal nucleic acid stress2021

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 83rd annual meeting og Japanese society of hematology
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Presentation] Toll様受容体を介した病原体認識と炎症制御2021

    • Author(s)
      三宅健介
    • Organizer
      第42回日本炎症・再生医学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21H04800
  • [Presentation] 炎症による単球・マクロファージ増殖の分子基盤2020

    • Author(s)
      三宅 健介
    • Organizer
      第41回日本炎症・再生医学会
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Presentation] Mechanisms controlling innate immune responses to nucleic acids2020

    • Author(s)
      Kensuke Miyake
    • Organizer
      United States-Japan Coopertive Medical Science Program, The 22nd international conference on emerging infectious diseases in the pacific rim.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22635
  • [Presentation] Mechanisms controlling innate immune responses to nucleic acids2020

    • Author(s)
      三宅 健介
    • Organizer
      日米医学 第22回EID会議
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Presentation] 炎症による単球・マクロファージ増殖の分子基盤2020

    • Author(s)
      三宅健介
    • Organizer
      第41回日本炎症・再生医学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K22635
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 26th international symposium on molecular cell biology of macrophages (MMCB2019)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04666
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 3rd annual Chiba-UCSD symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Presentation] 核酸特異的Toll様受容体と自己免疫疾患2019

    • Author(s)
      三宅 健介
    • Organizer
      第47回日本臨床免疫学会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-18H04666
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 26th international symposium on molecular cell biology of macrophages (MMCB2019)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22635
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019

    • Author(s)
      Kensuke Miyake
    • Organizer
      52nd annual meeting of the society for leukocyte biology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22635
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 3rd annual Chiba-UCSD symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04666
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019

    • Author(s)
      Kensuke Miyake
    • Organizer
      5th workshop in biosciences, International Alliance of Research Internship (IARI) 2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04666
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019

    • Author(s)
      Kensuke MIYAKE
    • Organizer
      5th workshop in biosciences, International Alliance of Research Internship (IARI) 2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019

    • Author(s)
      Kensuke Miyake
    • Organizer
      5th workshop in biosciences, International Alliance of Research Internship (IARI) 2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22635
  • [Presentation] 核酸特異的Toll様受容体と自己免疫疾患2019

    • Author(s)
      三宅 健介
    • Organizer
      第47回日本臨床免疫学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K22635
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019

    • Author(s)
      Kensuke MIYAKE
    • Organizer
      The 3rd annual Chiba-UCSD symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 3rd annual Chiba-UCSD symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22635
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019

    • Author(s)
      Kensuke MIYAKE
    • Organizer
      52nd annual meeting of the society for leukocyte biology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019

    • Author(s)
      Kensuke MIYAKE
    • Organizer
      The 26th international symposium on molecular cell biology of macrophages (MMCB2019)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019

    • Author(s)
      Kensuke Miyake
    • Organizer
      52nd annual meeting of the society for leukocyte biology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04666
  • [Presentation] 核酸特異的Toll様受容体と自己免疫疾患2019

    • Author(s)
      三宅健介
    • Organizer
      第47回日本臨床免疫学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018

    • Author(s)
      Kensuke Miyake
    • Organizer
      51st annual meeting of the society for leukocyte biology and 15th biennial meeting of the international endotoxin and innate immunity society
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04666
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 47th annual meeting of the Japanese society for immunology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04666
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 9th Asian congress of pediatric infectious diseases
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04666
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 47th annual meeting of the Japanese society for immunology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018

    • Author(s)
      Kensuke Miyake
    • Organizer
      51st annual meeting of the society for leukocyte biology and 15th biennial meeting of the international endotoxin and innate immunity society
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Presentation] Mechanism controlling TLR7 and their regulation in diseases2018

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 9th Asian congress of pediatric infectious diseases
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19548
  • [Presentation] Mechanism controlling TLR7 and their regulation in diseases2018

    • Author(s)
      Kensuke Miyake
    • Organizer
      International Union of Biochemistry and Molecular Biology 2018 (IUBMB2018)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19548
  • [Presentation] Mechanism controlling TLR7 and their regulation in diseases2018

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 47th annual meeting of the Japanese society for immunology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19548
  • [Presentation] Mechanism controlling TLR7 and their regulation in diseases2018

    • Author(s)
      Kensuke Miyake
    • Organizer
      51st annual meeting of the society for leukocyte biology and 15th biennial meeting of the international endotoxin and innate immunity society
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19548
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018

    • Author(s)
      Kensuke Miyake
    • Organizer
      International Union of Biochemistry and Molecular Biology 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018

    • Author(s)
      Kensuke Miyake
    • Organizer
      International Union of Biochemistry and Molecular Biology 2018 (IUBMB2018)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04666
  • [Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 9th Asian congress of pediatric infectious diseases
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06388
  • [Presentation] Molecular Mechanism controlling TLR7 responses in plasmacytoid dendritic cells2016

    • Author(s)
      Kensuke Miyake
    • Organizer
      International Congress of Immunology 2016
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02629
  • [Presentation] Innate Immune Response to nucleic acids in inflammatory disorders2015

    • Author(s)
      Kensuke Miyake
    • Organizer
      the 63rd annual meeting of the Japanese Association of Dental Research
    • Place of Presentation
      福岡国際会議場(福岡県 福岡市)
    • Year and Date
      2015-10-30
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25253032
  • [Presentation] Mechanisms regulating Nucleic acid-sensing Toll-like receptors2015

    • Author(s)
      三宅健介
    • Organizer
      日本細菌学会
    • Place of Presentation
      岐阜県岐阜市
    • Year and Date
      2015-03-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670235
  • [Presentation] Nucleic acid recognition by Toll-like receptors2015

    • Author(s)
      Kensuke Miyake
    • Organizer
      Innate Immunity Day, University of Massachusetts
    • Place of Presentation
      Worcester, USA
    • Year and Date
      2015-05-20
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253032
  • [Presentation] mTOR activation influences TLR3 signaling2015

    • Author(s)
      SATO Ryota, SAITOH Shin-Ichiro, SHIBATA Takuma, FUKUI Ryutaro, MURAKAMI Yusuke, KATO Akihisa, ARII Jun, KAWAGUCHI Yasushi, MIYAKE Kensuke
    • Organizer
      日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道 札幌市)
    • Year and Date
      2015-12-18
    • Data Source
      KAKENHI-PROJECT-15K15148
  • [Presentation] 自然炎症における核酸代謝と核酸センサーの役割2015

    • Author(s)
      三宅健介
    • Organizer
      第8回IgG4関連疾患研究会
    • Place of Presentation
      福井カリーせんとホテル
    • Year and Date
      2015-03-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670235
  • [Presentation] Nucleic Acid recognition by Toll-like receptors2015

    • Author(s)
      Kensuke Miyake
    • Organizer
      National Institute of Chemistry meeting in slovenia
    • Place of Presentation
      Ljubjana, Slovenia
    • Year and Date
      2015-06-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253032
  • [Presentation] The role of Nucleic acid processing in nucleic acid sensing by Toll-like receptors2015

    • Author(s)
      Kensuke Miyake
    • Organizer
      Toll 2015
    • Place of Presentation
      Marbella, Spain
    • Year and Date
      2015-09-30
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25253032
  • [Presentation] Toll様受容体によるRNA認識におけるRNAプロセシングの役割2015

    • Author(s)
      三宅健介
    • Organizer
      第88回日本生化学会年会
    • Place of Presentation
      神戸ポートアイランド (兵庫県 神戸市)
    • Year and Date
      2015-12-01
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25253032
  • [Presentation] TLR logistics by Unc93B1 as a mechanism regulating autoimmunity2013

    • Author(s)
      Kensuke Miyake
    • Organizer
      Frontiers in Innate Immunity
    • Place of Presentation
      Strasbourg, France
    • Invited
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] Nucleic acid-sensing Toll-like receptors: their recognition and regulation2013

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 21th international symposium of macrophage molecular and cellular biology
    • Place of Presentation
      Tokyo
    • Invited
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] Toll-like receptor logistics as a mechanism regulating autoimmunity2013

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 5th East Asian Group of Rheumatology
    • Place of Presentation
      Seoul, South Korea
    • Invited
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] TLR logistics by Unc93B1 as a mechanism regulating autoimmunity2013

    • Author(s)
      Kensuke Miyake
    • Organizer
      American Association of Immunologists (AAI) annual meeting 2013
    • Place of Presentation
      Hawaii, USA
    • Invited
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] Nucleic acid-sensing Toll-like receptors: their recognition and regulation2013

    • Author(s)
      Kensuke Miyake
    • Organizer
      The 86th annual meeting of the Japanese Society of Biochemical Society
    • Place of Presentation
      Yokohama Japan
    • Invited
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] Toll-like receptor logistics by Unc93B12012

    • Author(s)
      Miyake K
    • Organizer
      The biennial meeting of International endotoxin and innate immunity society
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2012-10-24
    • Invited
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] Toll-like receptor logistics by Unc93B12012

    • Author(s)
      Miyake K
    • Organizer
      The 85th Annual meeting of the Japanese Biochemical Society
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2012-12-15
    • Invited
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] Toll-like receptor 7 in plasmacytoid DCs as a target for enhancing anti-tumor immunity2012

    • Author(s)
      Miyake K
    • Organizer
      The 71st Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2012-09-20
    • Invited
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] Toll-like receptor logistics by Unc93B12012

    • Author(s)
      Miyake K
    • Organizer
      The 11th Awaji international forum on infection and immunity
    • Place of Presentation
      Awaji, Japan
    • Year and Date
      2012-09-12
    • Invited
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012

    • Author(s)
      Shibata Takuma, Takemura Naoki, Motoi Yuji, Goto Yoshiyuki, Uematsu Satoshi, Miyake Kensuke.
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸ポー トピアホテル、兵庫県
    • Year and Date
      2012-12-06
    • Data Source
      KAKENHI-PROJECT-24659145
  • [Presentation] Toll-like receptor logistics by Unc93B12012

    • Author(s)
      Miyake K
    • Organizer
      Novo Nordisk Innovation summit on chronic inflammation and autoimmune diseases
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2012-04-18
    • Invited
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] Toll-like receptor logistics by Unc93B1 as a mechanism regulating autoimmunity2012

    • Author(s)
      Miyake K
    • Organizer
      French-Japanese Meeting “Immune defenses in humans and model organisms.
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2012-09-21
    • Invited
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012

    • Author(s)
      Takuma Shibata, Naoki Takemura, Yuji Motoi, Satoshi Uematsu, Kensuke Miyake.
    • Organizer
      The 12th Biennial International Endotoxin & Innate Immunity Society(IEIIS) meeting
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2012-10-23
    • Data Source
      KAKENHI-PROJECT-24659145
  • [Presentation] Unc93 homolog B1 restricts lethal homeostatic inflammation by controlling TLR7 and TLR9 responses2011

    • Author(s)
      Ryutaro Fukui, Kensuke Miyake
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)(招待講演)
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] Human TLR4 polymorphisms influence cell surface expression and responses of TLR42011

    • Author(s)
      Natsuko Yamakawa, Sachiko Akashi-Takamura, Umeharu Ohto, Natsuko Tanimura, Toshiyuki Shimizu, Kensuke Miyake
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-28
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] MD-1 regulates the production of anti-phospholipid antibody2011

    • Author(s)
      Sachiko Akashi-Takamura, Natsuko Yamakawa, Kensuke Miyake
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing.2009

    • Author(s)
      三宅健介
    • Organizer
      Cold Spring Harbor meeting
    • Place of Presentation
      米国Cold Spring Harbor
    • Data Source
      KAKENHI-PLANNED-21117002
  • [Presentation] Unc93 homolog B1はTLR7とTLR9の応答性を相反的に制御する2009

    • Author(s)
      福井竜太郎, 松本文, 塚本裕美子, 斎藤伸一郎, 三宅健介
    • Organizer
      第39回日本免疫学会
    • Place of Presentation
      日本、大阪
    • Year and Date
      2009-12-04
    • Data Source
      KAKENHI-PROJECT-21659118
  • [Presentation] Unc93 homolog B1 regulates the balance of toll-like receptor 7 and toll-like receptor 9 responses reciprocally in dendritic cells2009

    • Author(s)
      Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeto K, Beutler B, Miyake K
    • Organizer
      Tri-Society Meeting(Society for Leukocyte Biology, International Cytokine Society, and International Society for Interferon and Cytokine Research)
    • Place of Presentation
      ポルトガル、リスボン
    • Year and Date
      2009-10-20
    • Data Source
      KAKENHI-PROJECT-21659118
  • [Presentation] A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors2008

    • Author(s)
      Kiyokawa T, Akashi-Takamura S, Shibata T, Matsumoto F, Nishitani C, Kuroki Y, Seto Y, Miyake K.
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-02
    • Data Source
      KAKENHI-PROJECT-20390140
  • [Presentation] Mechanisms regulating Nucleic acid-sensing Toll-like receptors

    • Author(s)
      三宅健介
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      新高輪プリンスホテル
    • Year and Date
      2014-04-24 – 2014-04-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253032
  • [Presentation] Toll様受容体による核酸認識の制御機構

    • Author(s)
      三宅健介
    • Organizer
      日本生化学会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-10-15 – 2014-10-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253032
  • [Presentation] Toll様受容体の活性制御機構とその破綻

    • Author(s)
      三宅健介
    • Organizer
      日本乾癬学会
    • Place of Presentation
      高知市文化プラザ カルポート
    • Year and Date
      2014-09-19 – 2014-09-20
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253032
  • [Presentation] Mechanisms regulating nucleic acid sensing Toll-like receptors

    • Author(s)
      三宅健介
    • Organizer
      第13回国際エンドトキシン自然免疫学会
    • Place of Presentation
      ソルトレークシティー  米国
    • Year and Date
      2014-10-23 – 2014-10-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253032
  • [Presentation] Toll様受容体の活性制御機構とその破綻

    • Author(s)
      三宅健介
    • Organizer
      第9回臨床ストレス応答学会
    • Place of Presentation
      岡山大学鹿田キャンパス
    • Year and Date
      2014-11-01 – 2014-11-02
    • Invited
    • Data Source
      KAKENHI-PROJECT-25253032
  • 1.  TAKAMURA Sachiko (00325599)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 7 results
  • 2.  KIMOTO Masao (40153225)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  SITOH Shin-ichiroh (90361625)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 4.  NAGASAWA Kohei (00108721)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  KAISHO Tsuneyasu (60224325)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  SHIBATA Takuma (30554505)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 7.  MUTA Tatsushi (60222337)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  KURATA Shoichiro (90221944)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KURANAGA Erina (90376591)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  OGAWA Yoshihiro (70291424)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  MARU Yoshiro (00251447)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  OHTO Umeharu (90451856)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 15 results
  • 13.  NAKANISHI Hiroki (10466740)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TADA Yoshifumi (70284627)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KOARADA Syuichi (50304887)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MATSUO Muneaki (20219398)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  SANO SHIGETOSHI (80273621)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  Moriyama Masafumi (20452774)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  阪口 薫雄 (70192086)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  高石 樹朗 (10303223)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  中島 喜美子 (20403892)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  山本 真有子 (20423478)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  寺石 美香 (40437736)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  石元 達士 (40750039)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  大湖 健太郎 (90595274)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  中村 誠司 (60189040)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  坪井 洋人 (80580505)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  清水 敏之 (30273858)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  淺原 弘嗣 (70294460)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  田岡 万悟 (60271160)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  山崎 晶 (40312946)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  和泉 自泰 (70622166)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  瀬川 勝盛 (20542971)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  安友 康二 (30333511)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  木村 元子 (00345018)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  浅野 謙一 (10513400)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  堀 昌平 (50392113)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  UEMURA Takefumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  FUKUI Ryutaro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 40.  OZAWA Manabu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 41.  INUI Masanori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 42.  青戸 一司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 43.  佐藤 亮太
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 44.  紺谷 圏二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 45.  内山 進
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 46.  渋谷 彰
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 47.  有井 潤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 48.  川口 寧
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 49.  山崎 聡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 50.  中溝 聡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi