Miyake Kensuke 三宅健介

… Alternative Names

MIYAKE Kensuke 三宅健介

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Researcher Number	60229812
Other IDs
Affiliation (Current)	2023: 東京大学, 医科学研究所, 教授
Affiliation (based on the past Project Information) *help	2001 – 2023: 東京大学, 医科学研究所, 教授 2003 – 2004: 東京大学, 医科学研究所・感染遺伝学分野, 教授 1993 – 2000: 佐賀医科大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Biological Sciences / Immunology / Immunology / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Transformative Research Areas, Section (III) / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Pathology, Infection/Immunology, and related fields / Pathological medical chemistry Except Principal Investigator 内科学一般 / Transformative Research Areas, Section (III) … More / Basic Section 57060:Surgical dentistry-related / Dermatology / Pediatrics / Immunology / Immunology Less
Keywords	Principal Investigator 自然免疫 / Toll様受容体 / Toll-like receptor / RP105 / MD-2 / 病原体 / ロイシンリッチリピート / B細胞 / LPS / MD-1 … More / Lipopolysaccharide / 病原体センサー / 遺伝子クローニング / 免疫学 / innate immunity / ノックアウトマウス / endotoxin / エンドトキシン / マウス / Lipopolyaccharide / leucine-rich repeat / リソソーム / natural antibody / 自然抗体 / Toll like receptor / pathogen / gene cloning / knockout mice / Blymphocytes / 一本鎖核酸 / TLR8 / TLR7 / TLR / 拡張型心筋症 / 病源体センサー / 自然得免疫 / セルソーター / アウトリーチ活動 / 遺伝子改変マウス / 炎症 / Toll-1ike receptor / 自己免疫疾患 / Toll-like Receptor / リポ多糖 / RP105アポトーシス … More Except Principal Investigator LPS / MD-2 / TLR4 / CD14 / RP105 / SLE / 自然免疫 / IFN-α / IL-1β / E5531 / LipdIVa / MD-1 / LBP / 自己抗体 / IgG / シェーグレン症候群 / アポトーシス / B細胞 / WF1マウス / B / 自己分子 / 免疫センサー / TNF-α / Toll 様受容体 8 / ヒトTLR8 Tg/マウスTLR8 KO マウス / TLR8 / モデルマウス / 単球/マクロファージ / Toll様受容体 / 紫外線照射 / トール様受容体 / 膠原病 / Toll-like receptor 3(TLR3) / double-stranded RNA(dsRNA) / febrile seizure / IL-1 / Toll-like receptor / 遺伝子多型 / 2本鎖RNA / Toll-like receptor-3 / 熱性けいれん / cytokine / ligand / bacterial expression / recombinant protein / トランスフェクタント / キメラ蛋白 / ノックアウト / CHO / 変異蛋白 / 融合蛋白 / アイソフォーム / 川崎病 / リコンピナント蛋白 / サイトカイン / リガンド / 大腸菌発現 / リコンビナント蛋白 / Anti-DNA antibody / Apoptosis / Dermatomyositis / Sjogren's syndrome / B cell / apoptosis / ステロイド / 活性化B細胞 / 免疫グロブリン / 抗DNA抗体 / 皮膚筋炎 / TCRレパトリ- / ペプチドモチーフ / クラスII分子 / 変異APC / T細胞クローン / 病原性自己ペプチド / トレランス / MB-1 / 抗原レセプター / シグナル伝達 / ホスファターゼ / 免疫抑制剤 / リン酸化 / 細胞周期 / ストレス / アミノ酸シークエンス / 結合ペプチドモチーフ / 自己ペプチド / 病原性自己反応性T細胞クローン / AαdクラスII分子 / Aβz / APC変異株 / 自己抗原ペプチド / 自己免疫疾患 / F1マウス / BW / クローン化T細胞 / 自己抗原処理・提示 / MHCクラスII分子変異細胞株 Less

Self-referential immune perception
- Principal Investigator
  
  山崎晶
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Osaka University
Molecular and structural bases enabling self-derived nucleic acid recognition in lysosomesPrincipal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
Molecular bases enabling various BCR responsesPrincipal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  The University of Tokyo
Studying molecular bases of alternative TLR responsesPrincipal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  The University of Tokyo
Studying innate immune responses to nucleoside stressPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokyo
自然免疫応答と脂質代謝の連携分子基盤の解明Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Novel therapeutic strategies for Sjogren's syndrome targeting Toll-like receptors.
- Principal Investigator
  
  Moriyama Masafumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kyushu University
Understanding a mechanism controlling endogenous retrovirus by Toll-like receptorsPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pathology, Infection/Immunology, and related fields
- Research Institution
  The University of Tokyo
Cell and Molecular mechanisms underlying the interaction between the innate immune system and metabolism in lysosomesPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
リソソームでの核酸認識における核酸代謝系の役割についての研究Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
The role of a transcription factor TFEB in the innate immune systemPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
The effect of UV irradiation on development of systemic lupus in mouse model
- Principal Investigator
  
  SANO SHIGETOSHI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Kochi University
Novel regulatory mechanism of TLR7/8 by ssRNAPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Molecular basis underlying Toll-like receptor logisticsPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
The role of innate immunity in Dilated CardiomyopathyPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
TOLL様受容体の認識機構と包括的活性制御機構の解明Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Homeostatic inflammation: Molecular basis and dysregulationPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Toll like receptors; their endogenous ligands and mechanism regulating their activitiesPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
自然免疫におけるDNA応答とRNA応答の間のバランス制御機構の解明Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Homeostatic inflammation: Molecular basis and dysregulationArea Organizer
- Area Organizer
  
  MIYAKE Kensuke
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
Toll様受容体の様受容体の内因性リガンドへの応答とその調節機構の解明Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Studying mechanisms controlling responsiveness of Toll-like ReceptorsPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
病原体センサと自己成分との相互作用についての研究Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Toll-like receptorファミリーの包括的活性制御機構の解明Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Analyses of Toll-like receptors regulating innate antibody response against microbial lipidsPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
The role of MD-2 in the pathogen recognition
- Principal Investigator
  
  AKASHI Sachiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
INF-α productivity and Toll-like receptor 3 gene polymorphism in patients with febrile seizure
- Principal Investigator
  
  MATSUO Muneaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Saga University
  佐賀医科大学
Roles for MD molecules in endotoxin recognitionPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Tollファミリー分子(TLR)によるLPS認識と獲得免疫発動機構の解明Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Tollファミリー分子による病原体認識機構の解明とそれを応用した癌免疫療法の開発Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Toll-like Receptorに会合するMDタンパクの遺伝学的解析Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Analysis of pathogen recognition by TLR4 and RP105 and their application to immunothrapy
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Saga University
  佐賀医科大学
The Function analysis of MD-2 molecule about LPS recognition
- Principal Investigator
  
  AKASHI Sachiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Tollファミリー分子による,細菌リポ多糖認識および自己糖脂質との識別機構の解明Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  佐賀医科大学
Tollファミリー分子による細菌リポ多糖認識機構解明とそのがん免疫療法への応用Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  佐賀医科大学
Recognition of Lipopolysaccharide by The Toll Receptor ComplexPrincipal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
  佐賀医科大学
癌免疫療法を目的としてロイシンリッチリピート分子の基礎的解析Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  佐賀医科大学
Analysis of RP105, a novel B cell-associated antigen, in autoimmune diseases
- Principal Investigator
  
  NAGASAWA Kohei
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Saga Medical School
ロイシンリッチリピートタンパクによる免疫システム制御機構の解析Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  佐賀医科大学
B細胞表面分子RP105についての個体レベル、分子レベルでの機能解析:会合分子の遺伝子単離とRP105ノックアウトマウスの作製Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  佐賀医科大学
CD40とRPl05経路によるB細胞活性化機構の比較、解析Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
Molecular and Cellular Analysis of a Leucine-rich Repeat Molecule RP105Principal Investigator
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Saga Medical School
RP105分子を介するマウスB細胞活性化機構の解析Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
マウスB細胞表面分子RP105のリガンドの検索及びシグナル伝達機構の解析Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  佐賀医科大学
MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
マウスB細胞のアポトーシスを阻害し、増殖を誘導する細胞表面抗原の遺伝子の単離Principal Investigator
- Principal Investigator
  
  三宅健介
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  佐賀医科大学
MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
B細胞のシグナル伝達
- Principal Investigator
  
  阪口薫雄
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
  Tottori University
MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学

[Book] medicina2013
- Author(s)
  柴田　琢磨、三宅　健介
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-24659145
[Journal Article] Dynamic control of nucleic-acid-sensing Toll-like receptors by the endosomal compartment.2021
- Author(s)
  Miyake K, Saitoh S-I, Fukui R, Shibata T, Sato R, and Murakami Y.
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 12 Pages: 835-840
- DOI
  10.1093/intimm/dxab037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H04900, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-21K15464
[Journal Article] Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors2021
- Author(s)
  Gavin Amanda L.、Huang Deli、Blane Tanya R.、Thinnes Therese C.、Murakami Yusuke、Fukui Ryutaro、Miyake Kensuke、Nemazee David
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1
- DOI
  10.1038/s41467-021-26150-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04800
[Journal Article] Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages2021
- Author(s)
  Liu Kaiwen、Sato Ryota、Shibata Takuma、Hiranuma Ryosuke、Reuter Tatjana、Fukui Ryutaro、Zhang Yun、Ichinohe Takeshi、Ozawa Manabu、Yoshida Nobuaki、Latz Eicke、Miyake Kensuke
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 9 Pages: 479-490
- DOI
  10.1093/intimm/dxab033
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03162, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-20H03491, KAKENHI-PROJECT-21K15464, KAKENHI-PROJECT-16H06276
[Journal Article] The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages2020
- Author(s)
  Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K.
- Journal Title
  
  Int Immunol
  
  Volume: 32 Issue: 12 Pages: 785-798
- DOI
  10.1093/intimm/dxaa055
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21612, KAKENHI-PUBLICLY-18H04856, KAKENHI-PUBLICLY-20H04900, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-20H03466, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-18K07169, KAKENHI-PROJECT-19K16685
[Journal Article] Phospholipase A2 from bee venom increases poly(I:C)-induced activation in human keratinocytes2020
- Author(s)
  Nakashima Akina、Tomono Susumu、Yamazaki Tatsuya、Inui Masanori、Morita Naoko、Ichimonji Isao、Takagi Hidekazu、Nagaoka Fumiaki、Matsumoto Misako、Ito Yasuhiko、Yanagishita Takeshi、Miyake Kensuke、Watanabe Daisuke、Akashi-Takamura Sachiko
- Journal Title
  
  International Immunology
  
  Volume: - Issue: 6 Pages: 371-383
- DOI
  10.1093/intimm/dxaa005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08874, KAKENHI-PROJECT-19K08500, KAKENHI-PROJECT-16H05898, KAKENHI-PROJECT-16H06388
[Journal Article] Endolysosomal compartments as platforms for orchestrating innate immune and metabolic sensors2019
- Author(s)
  Miyake Kensuke、Saitoh Shin‐ichiroh、Sato Ryota、Shibata Takuma、Fukui Ryutaro、Murakami Yusuke
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 106 Issue: 4 Pages: 853-862
- DOI
  10.1002/jlb.mr0119-020r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16685, KAKENHI-PUBLICLY-18H04666, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-19H03451
[Journal Article] Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs.2019
- Author(s)
  Furusho K, Shibata T, Sato R, Fukui R, Motoi Y, Zhang Y, Saitoh SI, Ichinohe T, Moriyama M, Nakamura S, Miyake, K.
- Journal Title
  
  International immunology.
  
  Volume: 31 Issue: 3 Pages: 167-173
- DOI
  10.1093/intimm/dxy075
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04856, KAKENHI-PROJECT-16H05193, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K22723, KAKENHI-PUBLICLY-18H04666, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-19H00976, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-16K08827
[Journal Article] ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus2019
- Author(s)
  Saitoh Shin-Ichiroh、Saitoh Yoshiko Mori、Kontani Kenji、Sato Katsuaki、Miyake Kensuke
- Journal Title
  
  International Immunology
  
  Volume: 31 Issue: 4 Pages: 225-237
- DOI
  10.1093/intimm/dxy084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07351, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16H06276
[Journal Article] Mechanisms controlling nucleic acid-sensing Toll-like receptors2018
- Author(s)
  Miyake Kensuke、Shibata Takuma、Ohto Umeharu、Shimizu Toshiyuki、Saitoh Shin-Ichiroh、Fukui Ryutaro、Murakami Yusuke
- Journal Title
  
  International Immunology
  
  Volume: 30 Issue: 2 Pages: 43-51
- DOI
  10.1093/intimm/dxy016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293083, KAKENHI-PUBLICLY-17H05991, KAKENHI-PROJECT-16K15253, KAKENHI-PUBLICLY-18H04666, KAKENHI-PUBLICLY-18H04856, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16K08827
[Journal Article] Biallelic Variants in CNPY3 , Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy2018
- Author(s)
  Mutoh Hiroki、Kato Mitsuhiro、Akita Tenpei、Shibata Takuma、Wakamoto Hiroyuki、Ikeda Hiroko、Kitaura Hiroki、Aoto Kazushi、Nakashima Mitsuko、Wang Tianying、Ohba Chihiro、Miyatake Satoko、Miyake Noriko、Kakita Akiyoshi、Miyake Kensuke、Fukuda Atsuo、Matsumoto Naomichi、Saitsu Hirotomo
- Journal Title
  
  The American Journal of Human Genetics
  
  Volume: 102 Issue: 2 Pages: 321-329
- DOI
  10.1016/j.ajhg.2018.01.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08513, KAKENHI-PROJECT-17K08534, KAKENHI-PROJECT-17K19682, KAKENHI-INTERNATIONAL-15K21731, KAKENHI-ORGANIZER-15H05871, KAKENHI-PLANNED-15H05872, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H05160, KAKENHI-PROJECT-17H04025, KAKENHI-PROJECT-15K06751, KAKENHI-PROJECT-17K00918, KAKENHI-PROJECT-17K10888, KAKENHI-PROJECT-16H06276
[Journal Article] Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA2018
- Author(s)
  Fukui Ryutaro、Yamamoto Chikako、Matsumoto Fumi、Onji Masahiro、Shibata Takuma、Murakami Yusuke、Kanno Atsuo、Hayashi Takuto、Tanimura Natsuko、Yoshida Nobuaki、Miyake Kensuke
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 1491-1491
- DOI
  10.3389/fimmu.2018.01491
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07169, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16K08827
[Journal Article] Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.2018
- Author(s)
  Sato R, Kato A, Chimura T, Saitoh SI, Shibata T, Murakami Y, Fukui R, Liu K, Zhang Y, Arii J, Sun-Wada GH, Wada Y, Ikenoue T, Barber GN, Manabe T, Kawaguchi Y, Miyake K.
- Journal Title
  
  Nat Immunol.
  
  Volume: 19 Issue: 10 Pages: 1071-1082
- DOI
  10.1038/s41590-018-0203-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-17K19549, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-15H05935, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PUBLICLY-18H04666, KAKENHI-PUBLICLY-18H04856, KAKENHI-PUBLICLY-18H04968, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-17H04080, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-16K08827
[Journal Article] Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication.2018
- Author(s)
  Maruzuru Y, Ichinohe T, Sato R, Miyake K, Okano T, Suzuki T, Koshiba T, Koyanagi N, Tsuda S, Watanabe M, Arii J, Kato A, Kawaguchi Y.
- Journal Title
  
  Cell Host Microbe.
  
  Volume: 23 Issue: 2 Pages: 254-265
- DOI
  10.1016/j.chom.2017.12.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08851, KAKENHI-PROJECT-16K15280, KAKENHI-PROJECT-26293102, KAKENHI-PROJECT-26713017, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06433, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-15H04730, KAKENHI-PROJECT-16H05193, KAKENHI-PROJECT-15J09601, KAKENHI-PROJECT-26460548, KAKENHI-PROJECT-15K15138, KAKENHI-PROJECT-17K19549, KAKENHI-PUBLICLY-18H04863, KAKENHI-PUBLICLY-18H04968, KAKENHI-PROJECT-17H03667, KAKENHI-PROJECT-17K19561, KAKENHI-PROJECT-17H05069, KAKENHI-PROJECT-16H06276
[Journal Article] Interleukin-33 produced by M2 macrophages and other immune cells contributes to Th2 immune reaction of IgG4-related disease.2017
- Author(s)
  Furukawa S, Moriyama M, Miyake K, Nakashima H, Tanaka A, Maehara T, Iizuka-Koga M, Tsuboi H, Hayashida JN, Ishiguro N, Yamauchi M, Sumida T, Nakamura S
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 42413-42413
- DOI
  10.1038/srep42413
- NAID
  120007135019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-15K11075, KAKENHI-PROJECT-17K18092, KAKENHI-PROJECT-26293430, KAKENHI-PROJECT-16J07704, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-17H04671
[Journal Article] Emerging roles of the processing of nucleic acids and Toll-like receptors in innate immune responses to nucleic acids2017
- Author(s)
  Miyake K, Shibata T, Ohto U, Shimizu T
- Journal Title
  
  J Leukoc Biol
  
  Volume: 101 Issue: 1 Pages: 135-142
- DOI
  10.1189/jlb.4mr0316-108r
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16K08827
[Journal Article] Selectivity of Human TLR9 for Double CpG Motifs and Implications for the Recognition of Genomic DNA2017
- Author(s)
  Pohar J, Yamamoto C, Fukui R, Cajnko MM, Miyake K, Jerala R, Bencina M
- Journal Title
  
  J Immunol
  
  Volume: 198 Issue: 5 Pages: 2093-2104
- DOI
  10.4049/jimmunol.1600757
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17K19548
[Journal Article] The protective effect of the anti-Toll-like receptor 9 antibody against acute cytokine storm caused by immunostimulatory DNA2017
- Author(s)
  Murakami Y, Fukui R, Motoi Y, Shibata T, Saitoh SI, Sato R, Miyake K.
- Journal Title
  
  Scientific Report
  
  Volume: 7 Issue: 1 Pages: 44042-44054
- DOI
  10.1038/srep44042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-16K15253, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16K08827
[Journal Article] Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos2017
- Author(s)
  Oka M, Hashimoto K, Yamaguchi Y, Saitoh SI, Sugiura Y, Motoi Y, Honda K, Kikko Y, Ohata S, Suematsu M, Miura M, Miyake K, Katada T and Kontani K
- Journal Title
  
  J Cell Sci
  
  Volume: 130 Pages: 3568-3577
- DOI
  10.1242/jcs.200519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07351, KAKENHI-PROJECT-26291038, KAKENHI-PROJECT-26293083, KAKENHI-PLANNED-26110005, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H05127, KAKENHI-PROJECT-17H03981, KAKENHI-PROJECT-16H06145, KAKENHI-PROJECT-16K15253
[Journal Article] Requirement of glycosylation machinery in TLR responses revealed by CRISPR/Cas9 screening2017
- Author(s)
  Sato Ryota、Shibata Takuma、Tanaka Yu、Kato Chiharu、Yamaguchi Kiyoshi、Furukawa Yoichi、Shimizu Eigo、Yamaguchi Rui、Imoto Seiya、Miyano Satoru、Miyake Kensuke
- Journal Title
  
  International Immunology
  
  Volume: 29 Issue: 8 Pages: 347-355
- DOI
  10.1093/intimm/dxx044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-17H03575, KAKENHI-PUBLICLY-16H01569, KAKENHI-PROJECT-16K08827
[Journal Article] TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells2017
- Author(s)
  Saitoh SI, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K and Miyake K
- Journal Title
  
  Nat Commun
  
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- DOI
  10.1038/s41467-017-01687-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07351, KAKENHI-PROJECT-17K19548, KAKENHI-PROJECT-26291038, KAKENHI-PROJECT-26293083, KAKENHI-PLANNED-16H06578, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H05193, KAKENHI-PROJECT-17H03981, KAKENHI-PROJECT-16K15253, KAKENHI-PROJECT-16K08827
[Journal Article] Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8.2016
- Author(s)
  Tanji, H., Ohto, U., Motoi, Y., Shibata, T., Miyake, K., & Shimizu, T.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A
  
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- DOI
  10.1073/pnas.1516000113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-15J12485, KAKENHI-PROJECT-16K08827
[Journal Article] Type I IFN Contributes to the Phenotype of Unc93b1D34A/D34A Mice by Regulating TLR7 Expression in B Cells and Dendritic Cells2016
- Author(s)
  Fukui R, Kanno A, Miyake K
- Journal Title
  
  J Immunol
  
  Volume: 196 Issue: 1 Pages: 416-427
- DOI
  10.4049/jimmunol.1500071
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-16H02629
[Journal Article] Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology2016
- Author(s)
  Pelka K, Shibata T, Miyake K, Latz E
- Journal Title
  
  Immunol Rev
  
  Volume: 269 Issue: 1 Pages: 60-75
- DOI
  10.1111/imr.12375
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06388
[Journal Article] Guanosine and its modified derivatives are endogenous ligands for TLR72016
- Author(s)
  Shibata T, Ohto U, Nomura S, Kibata K, Motoi Y, Zhang Y, Murakami Y, Fukui R, Ishimoto T, Sano S, Ito T, Shimizu T, Miyake K.
- Journal Title
  
  Int Immunol
  
  Volume: - Issue: 5 Pages: 211-222
- DOI
  10.1093/intimm/dxv062
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15148, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-16H02629, KAKENHI-PROJECT-16K08827
[Journal Article] Crystal structure of NOD2 and its implications in human disease.2016
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  Maekawa S, Ohto U, Shibata T, Miyake K, Shimizu T
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  Nat Commun
  
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  10.1038/ncomms11813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471
[Journal Article] Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling2016
- Author(s)
  Honda S, Sato K, Totsuka N, Fujiyama S, Fujimoto M, Miyake K, Nakahashi-Oda C, Tahara-Hanaoka S, Shibuya K, Shibuya A
- Journal Title
  
  Nat Commun
  
  Volume: 7 Issue: 1 Pages: 1-10
- DOI
  10.1038/ncomms11498
- NAID
  120007135503
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01365, KAKENHI-PROJECT-16H06387, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H05169, KAKENHI-PROJECT-14J00713, KAKENHI-PROJECT-26293383, KAKENHI-PROJECT-15K15319, KAKENHI-PROJECT-16K14629, KAKENHI-PROJECT-16K15455, KAKENHI-PROJECT-15H04862, KAKENHI-PROJECT-16H05350
[Journal Article] Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA2016
- Author(s)
  Zhang Z, Ohto U, Shibata T, Krayukhina E, Taoka M, Yamauchi Y, Tanji H, Isobe T, Uchiyama S, Miyake K, Shimizu T
- Journal Title
  
  Immunity
  
  Volume: 45 Issue: 4 Pages: 737-748
- DOI
  10.1016/j.immuni.2016.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-16H02494, KAKENHI-PROJECT-15J12485, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471, KAKENHI-PROJECT-16K08827
[Journal Article] Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes2015
- Author(s)
  Li X, Saitoh S, Shibata T, Tanimura N, Fukui R, Miyake K.
- Journal Title
  
  International immunology
  
  Volume: 27 Issue: 2 Pages: 83-94
- DOI
  10.1093/intimm/dxu086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J40043, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083
[Journal Article] DNase II-dependent DNA digestion is required for DNA sensing by TLR92015
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  Chan MP, Onji M, Fukui R, Kawane K, Shibata T, Saitoh SI, Ohto U, Shimizu T, Barber GN, *Miyake K
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  Nat Commun
  
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  10.1038/ncomms6853
- Peer Reviewed / Acknowledgement Compliant / Open Access
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  KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26713011, KAKENHI-PROJECT-25291010
[Journal Article] Toll-like receptor 8 senses degradation products of single-stranded RNA.2015
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  Tanji H, Ohto U, Shibata T, Taoka M, Yamauchi Y, Isobe T, Miyake K,
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  Nat Struct Mol Biol.
  
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  10.1038/nsmb.2943
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  KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25291010, KAKENHI-PROJECT-25650029, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-15J12485
[Journal Article] Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.2015
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  Ohto, U., Shibata, T., Tanji, H., Krayukhina, E., Uchiyama, S., Miyake, K., and Shimizu, T.
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  Nature
  
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  10.1038/nature14138
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25121722, KAKENHI-PUBLICLY-26102530, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25291010
[Journal Article] Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases2015
- Author(s)
  Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, Saitoh S, Miyake K.
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  Nature Communications
  
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  10.1038/ncomms7119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J40043, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083, KAKENHI-PROJECT-26670235, KAKENHI-PROJECT-26461597, KAKENHI-PROJECT-25291010
[Journal Article] Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses.2015
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  J Immunol.
  
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  10.4049/jimmunol.1402425
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- Data Source
  KAKENHI-PROJECT-25253032
[Journal Article] Lipopeptides are signaled by Toll-like receptor 1, 2, and 6 in endolysosomes2014
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  Int Immunol
  
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  10.1093/intimm/dxu054
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- Data Source
  KAKENHI-PROJECT-25253032
[Journal Article] UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 52014
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  Proc. Natl. Acad. Sci. USA
  
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  10.1073/pnas.1322838111
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-25860354
[Journal Article] Roles of the Cleaved N-Terminal TLR3 Fragment and Cell Surface TLR3 in Double-Stranded RNA Sensing2014
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  Murakami Y, Fukui R, Motoi Y, Kanno A, Shibata T, Tanimura N, Saitoh SI, *Miyake K
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  J Immunol
  
  Volume: 193 Pages: 5208-5217
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- Data Source
  KAKENHI-PROJECT-25253032
[Journal Article] Endocytosis-free DNA sensing by cell surface TLR9 in neutrophils: Rapid defense with autoimmune risks2013
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  Miyake K, Onji M
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  Eur J Immunol
  
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  10.1002/eji.201343882
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-25253032
[Journal Article] Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in intramolecular disulfide bond, proteolytic cleavage, and RNA-sensing2013
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  Kanno A, Yamamoto C, Onji M, Fukui R, Saitoh SI, Motoi Y, Shibata T, Matsumoto F, Muta T, Miyake K
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  Int Immunol.
  
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  10.1093/intimm/dxt007
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117004, KAKENHI-PROJECT-21390088, KAKENHI-PUBLICLY-24117706, KAKENHI-PROJECT-24390076, KAKENHI-PROJECT-24659145, KAKENHI-PROJECT-25670189, KAKENHI-PLANNED-21117002
[Journal Article] The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of TLR4/MD2 complex at the plasma membrane2013
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  Tanimura N, Saitoh S, Ohto U, Akashi-Takamura A, Fujimoto Y, Fukase K, Shimizu T, Miyake K
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  Int. Immunol.
  
  Volume: 26 Issue: 6 Pages: 307-314
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  10.1093/intimm/dxt071
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23241074, KAKENHI-PROJECT-23590564, KAKENHI-PUBLICLY-24117706, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-26293083
[Journal Article] Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A2013
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  Yamakawa N, Ohto U, Akashi-Takamura S, Takahashi K, Saitoh SI, Tanimura N, Suganami T, Ogawa Y, Shibata T, Shimizu T, Miyake K
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  Int Immunol.
  
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  KAKENHI-PLANNED-21117002
[Journal Article] An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing2013
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  Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K
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  Nat. Commun.
  
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  10.1038/ncomms2949
- NAID
  120005359107
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- Data Source
  KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23229004, KAKENHI-PUBLICLY-24117706, KAKENHI-PROJECT-25253032, KAKENHI-PROJECT-25460585, KAKENHI-PROJECT-25670189, KAKENHI-PROJECT-25860353
[Journal Article] Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands2013
- Author(s)
  Tanji H, Ohto U, Shibata T, Miyake K, Shimizu T
- Journal Title
  
  Science
  
  Volume: 339 Issue: 6126 Pages: 1426-1429
- DOI
  10.1126/science.1229159
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23770106, KAKENHI-PROJECT-24659145, KAKENHI-PROJECT-25291010, KAKENHI-PUBLICLY-23121510
[Journal Article] Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-22012
- Author(s)
  Ohto U, Fukase K, Miyake K, Shimizu T
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 109 Issue: 19 Pages: 7421-7426
- DOI
  10.1073/pnas.1201193109
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23241074, KAKENHI-PLANNED-23116007, KAKENHI-PUBLICLY-23121510
[Journal Article] Structural analyses of human Toll-like receptor polymorphisms D299G and T399I2012
- Author(s)
  Ohto U, Yamakawa N, Akashi-Takamura S, Miyake K, Shimizu T
- Journal Title
  
  J Biol Chem.
  
  Volume: 287 Issue: 48 Pages: 40611-40617
- DOI
  10.1074/jbc.m112.404608
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-22370045, KAKENHI-PROJECT-23590564, KAKENHI-PUBLICLY-23121510
[Journal Article] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012
- Author(s)
  Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K
- Journal Title
  
  Int Immunol.
  
  Volume: 24 Issue: 10 Pages: 613-623
- DOI
  10.1093/intimm/dxs068
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21117001, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-23790526, KAKENHI-PROJECT-24659145, KAKENHI-PROJECT-24790463
[Journal Article] Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeoatasis.2011
- Author(s)
  Hirai M, Kadowaki N, Kitawaki T, Fujita H, Takaori-Kondo A, Fukui R, Miyake K, Maeda T, Kamihira S, Miyachi Y, Uchiyama T.
- Journal Title
  
  BLOOD
  
  Volume: 117 Pages: 500-509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659118
[Journal Article] Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis.2011
- Author(s)
  Hirai M, Kadowaki N, Kitawaki T, Fujita H, Takaori-Kondo A, Fukui R, Miyake K, Maeda T, Kamihira S, Miyachi Y, Uchiyama T.
- Journal Title
  
  BLOOD
  
  Volume: 117 Pages: 500-509
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002
[Journal Article] Novel dimer organization of the TLR family as revealed by the crystal structures of mouse and human RP105/MD-1 complex2011
- Author(s)
  Ohto U, Miyake K, Shimizu T
- Journal Title
  
  J.Mol.Biol.
  
  Volume: 413 Issue: 4 Pages: 815-825
- DOI
  10.1016/j.jmb.2011.09.020
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PLANNED-23116007, KAKENHI-PUBLICLY-23121510
[Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9-trafficking2011
- Author(s)
  Fukui R, Saitoh S-I, Kanno A, Onji M, Shibata T, Ito A, Onji M, Matsumoto M, Akira S, Yoshida N, Miyake K
- Journal Title
  
  Immunity
  
  Volume: 35 Pages: 69-81
- Data Source
  KAKENHI-PLANNED-21117002
[Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating TLR7- and TLR9-trafficking.2011
- Author(s)
  Fukui R, Saitoh S-I, Kanno A, Onji M, Shibata T, Ito A, Onji M, Matsumoto M, Akira S, Yoshida N, Miyake K.
- Journal Title
  
  Immunity in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390140
[Journal Article] Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes2011
- Author(s)
  Shibata T, Motoi Y, Tanimura N, Yamakawa N, Akashi-Takamura S, Miyake, K
- Journal Title
  
  Int.Immunol.
  
  Volume: 23 Issue: 8 Pages: 503-510
- DOI
  10.1093/intimm/dxr044
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002, KAKENHI-PUBLICLY-22117505, KAKENHI-PROJECT-23590564
[Journal Article] Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes.2011
- Author(s)
  Shibata T, Motoi Y, Tanimura N, Yamakawa N, Akashi-Takamura S, Miyake, K
- Journal Title
  
  Int.Immunol. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390140
[Journal Article] Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking2011
- Author(s)
  Fukui R
- Journal Title
  
  Immunity
  
  Volume: 35 Issue: 1 Pages: 69-81
- DOI
  10.1016/j.immuni.2011.05.010
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059010, KAKENHI-PLANNED-21117002, KAKENHI-PROJECT-21390298, KAKENHI-PROJECT-22500286, KAKENHI-PROJECT-22659097, KAKENHI-PROJECT-22790454, KAKENHI-PUBLICLY-23118520
[Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing2009
- Author(s)
  Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, *^Miyake K.
- Journal Title
  
  J.Exp.Med 206
  
  Pages: 1339-1350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20060007
[Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA- but against RNA-sensing2009
- Author(s)
  Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, *Miyake K
- Journal Title
  
  The Journal of Experimental Medicine 206
  
  Pages: 1339-1350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390140
[Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA- but against RNA-sensing2009
- Author(s)
  Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, Miyake K
- Journal Title
  
  The Journal of Experimental Medicine 206
  
  Pages: 1339-1350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659118
[Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing2009
- Author(s)
  Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, and Miyake K
- Journal Title
  
  J. Exp. Med.
  
  Volume: 206 Pages: 1339-1350
- Data Source
  KAKENHI-PLANNED-21117002
[Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA- but against RNA-sensing.2009
- Author(s)
  Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, *Miyake K.
- Journal Title
  
  J.Exp.Med. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390140
[Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing.2009
- Author(s)
  Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, Miyake K.
- Journal Title
  
  J.Exp.Med
  
  Volume: 206 Pages: 1339-1350
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117002
[Journal Article] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing2009
- Author(s)
  Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeta K, Beutler B, *^Miyake K.
- Journal Title
  
  J.Exp.Med. 206
  
  Pages: 1339-1350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21022017
[Journal Article] Cathepsins are required for Toll-like receptor 9 responses.2008
- Author(s)
  Matsumoto F, Saitoh S, Fukui R, Kobayashi T, Tanimura N, Konno K, Kusumoto Y, Akashi-Takamura S, *Miyake K.
- Journal Title
  
  Biochem Biophys Res Commun. 367
  
  Pages: 693-699
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390140
[Journal Article] Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/1pr mice2008
- Author(s)
  Kobayashi, T., K.Takahashi, Y.Nagai, T.Shibata, M.Otani, S.Izui, S.Akira, Y.Gotoh, H.Kiyono, K.Miyake
- Journal Title
  
  International Immunology 20
  
  Pages: 881-891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390140
[Journal Article] Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice2008
- Author(s)
  Kobayashi, T., K. Takahashi, Y. Nagai, T. Shibata, M. Otani, S. Izui, S. Akira, Y. Gotoh, H. Kiyono, and K. Miyake.
- Journal Title
  
  Int. Immunol 20
  
  Pages: 881-891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20060007
[Journal Article] A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors2008
- Author(s)
  Kiyokawa T, Akashi-Takamura S, Shibata T, Matsumoto F, Nishitani C, Kuroki Y, Seto Y, Miyake K.
- Journal Title
  
  International Immunology 20
  
  Pages: 1407-1415
- NAID
  10024357741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390140
[Journal Article] Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling.2008
- Author(s)
  Tanimura N, Saitoh S, Matsumoto F, Akashi-Takamura S, *Miyake K.
- Journal Title
  
  Biochem Biophys Res Commun. 368
  
  Pages: 94-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390140
[Journal Article] A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors2008
- Author(s)
  Kiyokawa T, Akashi-Takamura S, S hibata T, Matsumoto F, Nishitani C, Kuroki Y, Seto Y and Miyake K.
- Journal Title
  
  Int. Immunol. 20
  
  Pages: 1407-1415
- NAID
  10024357741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041024
[Journal Article] Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.2008
- Author(s)
  Kobayshi, T., K. Takahashi, Y.Nagai, T. Shibata, M. Otani, S. Izui, S. Akira, Y. Gotoh, H. Kiyono, and K. Miyake.
- Journal Title
  
  Int. Immunol. 20
  
  Pages: 881-891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659074
[Journal Article] A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors.2008
- Author(s)
  Kiyokawa T, Akashi-Takamura S, Shibata T, Matsumoto F, Nishitani C, Kuroki Y, Seto Y, *Miyake K.
- Journal Title
  
  Int.Immunol. 20
  
  Pages: 1407-1415
- NAID
  10024357741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390140
[Journal Article] Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.2008
- Author(s)
  Kobayashi, T., K.Takahashi, Y.Nagai, T.Shibata, M.Otani, S.Izui, S.Akira, Y.Gotoh, H.Kiyono, *Miyake K
- Journal Title
  
  Int.Immunol. 20
  
  Pages: 881-891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390140
[Journal Article] Endotoxin recognition molecules MD-2 and toll-like receptor 4 as potential targets for therapeutic intervention of endotoxin shock.2004
- Author(s)
  Miyake K.
- Journal Title
  
  Curr Drug Targets Inflamm Allergy 3
  
  Pages: 291-297
- Data Source
  KAKENHI-PROJECT-16390142
[Journal Article] Endotoxin recognition molecules, Toll-like receptor 4-MD-2.2004
- Author(s)
  Miyake K.
- Journal Title
  
  Semin Immunol. 16
  
  Pages: 11-16
- Data Source
  KAKENHI-PROJECT-14021012
[Journal Article] Endotoxin recognition molecules MD-2 and toll-like receptor 4 as potential targets for therapeutic intervention of endotoxin shock.2004
- Author(s)
  Miyake K.
- Journal Title
  
  Curr Drug Targets Inflamm Allergy. 3
  
  Pages: 291-297
- Data Source
  KAKENHI-PROJECT-14021012
[Journal Article] Endotoxin recognition molecules, Toll-like receptor 4-MD-2.2004
- Author(s)
  Miyake K.
- Journal Title
  
  Semin Immunol. 16
  
  Pages: 11-16
- Data Source
  KAKENHI-PROJECT-16390142
[Patent] 炎症性疾患の予防又は治療剤2013
- Inventor(s)
  三宅健介、菅野敦夫、恩地正浩、本井祐二
- Industrial Property Rights Holder
  東京大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-089575
- Filing Date
  2013-04-22
- Data Source
  KAKENHI-ORGANIZER-21117001
[Patent] 炎症性疾患の予防又は治療剤2013
- Inventor(s)
  三宅健介、菅野敦夫、恩地正浩、本井祐二
- Industrial Property Rights Holder
  東京大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-089575
- Filing Date
  2013-04-22
- Data Source
  KAKENHI-PLANNED-21117002
[Patent] Unc93B1遺伝子改変マウスの確立とその応用2010
- Inventor(s)
  三宅健介、斎藤伸一郎、福井竜太郎
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2010-08-10
- Overseas
- Data Source
  KAKENHI-PROJECT-20390140
[Presentation] RNA metabolism and RNA-sensing in the endosomal compartment2021
- Author(s)
  Kensuke Miyake
- Organizer
  The 16th meeting of the international endotoxin and innate immunity society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04800
[Presentation] RNA metabolism and RNA-sensing in the endosomal compartment2021
- Author(s)
  Kensuke Miyake
- Organizer
  The 27th international symposium on molecular cell biology of macrophages
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04800
[Presentation] 核酸特異的Toll様受容体の活性制御機構とその破綻によるヒト疾患2021
- Author(s)
  三宅健介
- Organizer
  第6回ゲノム創薬・創発フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-21H04800
[Presentation] 核酸に対する自然免疫応答と炎症性疾患2021
- Author(s)
  三宅　健介
- Organizer
  医薬品研究開発にかかる発表会・セミナー　（富山県薬事総合開発研究センター）
- Invited
- Data Source
  KAKENHI-PROJECT-16H06388
[Presentation] Histiocytosis due to lysosomal nucleic acid stress2021
- Author(s)
  Kensuke Miyake
- Organizer
  The 83rd annual meeting og Japanese society of hematology
- Invited
- Data Source
  KAKENHI-PROJECT-21H04800
[Presentation] Toll様受容体を介した病原体認識と炎症制御2021
- Author(s)
  三宅健介
- Organizer
  第42回日本炎症・再生医学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04800
[Presentation] 炎症による単球・マクロファージ増殖の分子基盤2020
- Author(s)
  三宅　健介
- Organizer
  第41回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-16H06388
[Presentation] Mechanisms controlling innate immune responses to nucleic acids2020
- Author(s)
  三宅　健介
- Organizer
  日米医学　第22回EID会議
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06388
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019
- Author(s)
  Kensuke Miyake
- Organizer
  The 26th international symposium on molecular cell biology of macrophages (MMCB2019)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04666
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019
- Author(s)
  Kensuke Miyake
- Organizer
  The 3rd annual Chiba-UCSD symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06388
[Presentation] 核酸特異的Toll様受容体と自己免疫疾患2019
- Author(s)
  三宅　健介
- Organizer
  第47回日本臨床免疫学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04666
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019
- Author(s)
  Kensuke Miyake
- Organizer
  The 3rd annual Chiba-UCSD symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04666
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019
- Author(s)
  Kensuke Miyake
- Organizer
  5th workshop in biosciences, International Alliance of Research Internship (IARI) 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04666
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019
- Author(s)
  Kensuke MIYAKE
- Organizer
  5th workshop in biosciences, International Alliance of Research Internship (IARI) 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06388
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019
- Author(s)
  Kensuke MIYAKE
- Organizer
  The 3rd annual Chiba-UCSD symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06388
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019
- Author(s)
  Kensuke MIYAKE
- Organizer
  52nd annual meeting of the society for leukocyte biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06388
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019
- Author(s)
  Kensuke MIYAKE
- Organizer
  The 26th international symposium on molecular cell biology of macrophages (MMCB2019)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06388
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2019
- Author(s)
  Kensuke Miyake
- Organizer
  52nd annual meeting of the society for leukocyte biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04666
[Presentation] 核酸特異的Toll様受容体と自己免疫疾患2019
- Author(s)
  三宅健介
- Organizer
  第47回日本臨床免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06388
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018
- Author(s)
  Kensuke Miyake
- Organizer
  51st annual meeting of the society for leukocyte biology and 15th biennial meeting of the international endotoxin and innate immunity society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04666
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018
- Author(s)
  Kensuke Miyake
- Organizer
  The 47th annual meeting of the Japanese society for immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04666
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018
- Author(s)
  Kensuke Miyake
- Organizer
  The 9th Asian congress of pediatric infectious diseases
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04666
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018
- Author(s)
  Kensuke Miyake
- Organizer
  The 47th annual meeting of the Japanese society for immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06388
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018
- Author(s)
  Kensuke Miyake
- Organizer
  51st annual meeting of the society for leukocyte biology and 15th biennial meeting of the international endotoxin and innate immunity society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06388
[Presentation] Mechanism controlling TLR7 and their regulation in diseases2018
- Author(s)
  Kensuke Miyake
- Organizer
  The 9th Asian congress of pediatric infectious diseases
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19548
[Presentation] Mechanism controlling TLR7 and their regulation in diseases2018
- Author(s)
  Kensuke Miyake
- Organizer
  International Union of Biochemistry and Molecular Biology 2018 (IUBMB2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19548
[Presentation] Mechanism controlling TLR7 and their regulation in diseases2018
- Author(s)
  Kensuke Miyake
- Organizer
  The 47th annual meeting of the Japanese society for immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19548
[Presentation] Mechanism controlling TLR7 and their regulation in diseases2018
- Author(s)
  Kensuke Miyake
- Organizer
  51st annual meeting of the society for leukocyte biology and 15th biennial meeting of the international endotoxin and innate immunity society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19548
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018
- Author(s)
  Kensuke Miyake
- Organizer
  International Union of Biochemistry and Molecular Biology 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06388
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018
- Author(s)
  Kensuke Miyake
- Organizer
  International Union of Biochemistry and Molecular Biology 2018 (IUBMB2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04666
[Presentation] Mechanisms Controlling Innate Immune Responses to Nucleic Acids2018
- Author(s)
  Kensuke Miyake
- Organizer
  The 9th Asian congress of pediatric infectious diseases
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06388
[Presentation] Molecular Mechanism controlling TLR7 responses in plasmacytoid dendritic cells2016
- Author(s)
  Kensuke Miyake
- Organizer
  International Congress of Immunology 2016
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02629
[Presentation] Innate Immune Response to nucleic acids in inflammatory disorders2015
- Author(s)
  Kensuke Miyake
- Organizer
  the 63rd annual meeting of the Japanese Association of Dental Research
- Place of Presentation
  福岡国際会議場（福岡県　福岡市）
- Year and Date
  2015-10-30
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253032
[Presentation] Mechanisms regulating Nucleic acid-sensing Toll-like receptors2015
- Author(s)
  三宅健介
- Organizer
  日本細菌学会
- Place of Presentation
  岐阜県岐阜市
- Year and Date
  2015-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-26670235
[Presentation] Nucleic acid recognition by Toll-like receptors2015
- Author(s)
  Kensuke　Miyake
- Organizer
  Innate Immunity Day, University of Massachusetts
- Place of Presentation
  Worcester, USA
- Year and Date
  2015-05-20
- Invited
- Data Source
  KAKENHI-PROJECT-25253032
[Presentation] mTOR activation influences TLR3 signaling2015
- Author(s)
  SATO Ryota, SAITOH Shin-Ichiro, SHIBATA Takuma, FUKUI Ryutaro, MURAKAMI Yusuke, KATO Akihisa, ARII Jun, KAWAGUCHI Yasushi, MIYAKE Kensuke
- Organizer
  日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター(北海道　札幌市）
- Year and Date
  2015-12-18
- Data Source
  KAKENHI-PROJECT-15K15148
[Presentation] 自然炎症における核酸代謝と核酸センサーの役割2015
- Author(s)
  三宅健介
- Organizer
  第8回IgG4関連疾患研究会
- Place of Presentation
  福井カリーせんとホテル
- Year and Date
  2015-03-21
- Invited
- Data Source
  KAKENHI-PROJECT-26670235
[Presentation] Nucleic Acid recognition by Toll-like receptors2015
- Author(s)
  Kensuke Miyake
- Organizer
  National Institute of Chemistry meeting in slovenia
- Place of Presentation
  Ljubjana, Slovenia
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-25253032
[Presentation] The role of Nucleic acid processing in nucleic acid sensing by Toll-like receptors2015
- Author(s)
  Kensuke Miyake
- Organizer
  Toll 2015
- Place of Presentation
  Marbella, Spain
- Year and Date
  2015-09-30
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253032
[Presentation] Toll様受容体によるRNA認識におけるRNAプロセシングの役割2015
- Author(s)
  三宅健介
- Organizer
  第88回日本生化学会年会
- Place of Presentation
  神戸ポートアイランド　(兵庫県　神戸市）
- Year and Date
  2015-12-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253032
[Presentation] TLR logistics by Unc93B1 as a mechanism regulating autoimmunity2013
- Author(s)
  Kensuke Miyake
- Organizer
  Frontiers in Innate Immunity
- Place of Presentation
  Strasbourg, France
- Invited
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] Nucleic acid-sensing Toll-like receptors: their recognition and regulation2013
- Author(s)
  Kensuke Miyake
- Organizer
  The 21th international symposium of macrophage molecular and cellular biology
- Place of Presentation
  Tokyo
- Invited
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] Toll-like receptor logistics as a mechanism regulating autoimmunity2013
- Author(s)
  Kensuke Miyake
- Organizer
  The 5th East Asian Group of Rheumatology
- Place of Presentation
  Seoul, South Korea
- Invited
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] TLR logistics by Unc93B1 as a mechanism regulating autoimmunity2013
- Author(s)
  Kensuke Miyake
- Organizer
  American Association of Immunologists (AAI) annual meeting 2013
- Place of Presentation
  Hawaii, USA
- Invited
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] Nucleic acid-sensing Toll-like receptors: their recognition and regulation2013
- Author(s)
  Kensuke Miyake
- Organizer
  The 86th annual meeting of the Japanese Society of Biochemical Society
- Place of Presentation
  Yokohama Japan
- Invited
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] Toll-like receptor logistics by Unc93B12012
- Author(s)
  Miyake K
- Organizer
  The biennial meeting of International endotoxin and innate immunity society
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2012-10-24
- Invited
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] Toll-like receptor logistics by Unc93B12012
- Author(s)
  Miyake K
- Organizer
  The 85th Annual meeting of the Japanese Biochemical Society
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2012-12-15
- Invited
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] Toll-like receptor 7 in plasmacytoid DCs as a target for enhancing anti-tumor immunity2012
- Author(s)
  Miyake K
- Organizer
  The 71st Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Sapporo, Japan
- Year and Date
  2012-09-20
- Invited
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] Toll-like receptor logistics by Unc93B12012
- Author(s)
  Miyake K
- Organizer
  The 11th Awaji international forum on infection and immunity
- Place of Presentation
  Awaji, Japan
- Year and Date
  2012-09-12
- Invited
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012
- Author(s)
  Shibata Takuma, Takemura Naoki, Motoi Yuji, Goto Yoshiyuki, Uematsu Satoshi, Miyake Kensuke.
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸ポートピアホテル、兵庫県
- Year and Date
  2012-12-06
- Data Source
  KAKENHI-PROJECT-24659145
[Presentation] Toll-like receptor logistics by Unc93B12012
- Author(s)
  Miyake K
- Organizer
  Novo Nordisk Innovation summit on chronic inflammation and autoimmune diseases
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2012-04-18
- Invited
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] Toll-like receptor logistics by Unc93B1 as a mechanism regulating autoimmunity2012
- Author(s)
  Miyake K
- Organizer
  French-Japanese Meeting “Immune defenses in humans and model organisms.
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2012-09-21
- Invited
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells2012
- Author(s)
  Takuma Shibata, Naoki Takemura, Yuji Motoi, Satoshi Uematsu, Kensuke Miyake.
- Organizer
  The 12th Biennial International Endotoxin & Innate Immunity Society(IEIIS) meeting
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2012-10-23
- Data Source
  KAKENHI-PROJECT-24659145
[Presentation] Unc93 homolog B1 restricts lethal homeostatic inflammation by controlling TLR7 and TLR9 responses2011
- Author(s)
  Ryutaro Fukui, Kensuke Miyake
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉県)(招待講演)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] Human TLR4 polymorphisms influence cell surface expression and responses of TLR42011
- Author(s)
  Natsuko Yamakawa, Sachiko Akashi-Takamura, Umeharu Ohto, Natsuko Tanimura, Toshiyuki Shimizu, Kensuke Miyake
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] MD-1 regulates the production of anti-phospholipid antibody2011
- Author(s)
  Sachiko Akashi-Takamura, Natsuko Yamakawa, Kensuke Miyake
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells towards DNA-but against RNA-sensing.2009
- Author(s)
  三宅健介
- Organizer
  Cold Spring Harbor meeting
- Place of Presentation
  米国Cold Spring Harbor
- Data Source
  KAKENHI-PLANNED-21117002
[Presentation] Unc93 homolog B1はTLR7とTLR9の応答性を相反的に制御する2009
- Author(s)
  福井竜太郎, 松本文, 塚本裕美子, 斎藤伸一郎, 三宅健介
- Organizer
  第39回日本免疫学会
- Place of Presentation
  日本、大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-21659118
[Presentation] Unc93 homolog B1 regulates the balance of toll-like receptor 7 and toll-like receptor 9 responses reciprocally in dendritic cells2009
- Author(s)
  Fukui R, Saitoh S-I, Matsumoto F, Kozuka-Hara H, Oyama M, Tabeto K, Beutler B, Miyake K
- Organizer
  Tri-Society Meeting(Society for Leukocyte Biology, International Cytokine Society, and International Society for Interferon and Cytokine Research)
- Place of Presentation
  ポルトガル、リスボン
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-21659118
[Presentation] A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors2008
- Author(s)
  Kiyokawa T, Akashi-Takamura S, Shibata T, Matsumoto F, Nishitani C, Kuroki Y, Seto Y, Miyake K.
- Organizer
  日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20390140
[Presentation] Mechanisms regulating Nucleic acid-sensing Toll-like receptors
- Author(s)
  三宅健介
- Organizer
  日本リウマチ学会
- Place of Presentation
  新高輪プリンスホテル
- Year and Date
  2014-04-24 – 2014-04-25
- Invited
- Data Source
  KAKENHI-PROJECT-25253032
[Presentation] Toll様受容体による核酸認識の制御機構
- Author(s)
  三宅健介
- Organizer
  日本生化学会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-25253032
[Presentation] Toll様受容体の活性制御機構とその破綻
- Author(s)
  三宅健介
- Organizer
  日本乾癬学会
- Place of Presentation
  高知市文化プラザ　カルポート
- Year and Date
  2014-09-19 – 2014-09-20
- Invited
- Data Source
  KAKENHI-PROJECT-25253032
[Presentation] Mechanisms regulating nucleic acid sensing Toll-like receptors
- Author(s)
  三宅健介
- Organizer
  第13回国際エンドトキシン自然免疫学会
- Place of Presentation
  ソルトレークシティー　米国
- Year and Date
  2014-10-23 – 2014-10-25
- Invited
- Data Source
  KAKENHI-PROJECT-25253032
[Presentation] Toll様受容体の活性制御機構とその破綻
- Author(s)
  三宅健介
- Organizer
  第9回臨床ストレス応答学会
- Place of Presentation
  岡山大学鹿田キャンパス
- Year and Date
  2014-11-01 – 2014-11-02
- Invited
- Data Source
  KAKENHI-PROJECT-25253032

1. TAKAMURA Sachiko (00325599)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
2. KIMOTO Masao (40153225)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. SITOH Shin-ichiroh (90361625)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. NAGASAWA Kohei (00108721)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KAISHO Tsuneyasu (60224325)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SHIBATA Takuma (30554505)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. MUTA Tatsushi (60222337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. KURATA Shoichiro (90221944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KURANAGA Erina (90376591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OGAWA Yoshihiro (70291424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MARU Yoshiro (00251447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OHTO Umeharu (90451856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
13. NAKANISHI Hiroki (10466740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TADA Yoshifumi (70284627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KOARADA Syuichi (50304887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MATSUO Muneaki (20219398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SANO SHIGETOSHI (80273621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Moriyama Masafumi (20452774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 阪口薫雄 (70192086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 高石樹朗 (10303223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 中島喜美子 (20403892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 山本真有子 (20423478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 寺石美香 (40437736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 石元達士 (40750039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 大湖健太郎 (90595274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 中村誠司 (60189040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 坪井洋人 (80580505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 山崎晶 (40312946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 和泉自泰 (70622166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 瀬川勝盛 (20542971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 安友康二 (30333511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 木村元子 (00345018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 浅野謙一 (10513400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 堀昌平 (50392113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 清水敏之 (30273858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 淺原弘嗣 (70294460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. FUKUI Ryutaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. OZAWA Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. INUI Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 青戸一司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 佐藤亮太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 紺谷圏二

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
43. 内山進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 渋谷彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 有井潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
46. 山崎聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyake Kensuke 三宅 健介

MIYAKE Kensuke 三宅 健介

Research Projects

Research Products

Co-Researchers

Self-referential immune perception

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Molecular and structural bases enabling self-derived nucleic acid recognition in lysosomesPrincipal Investigator

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Molecular bases enabling various BCR responsesPrincipal Investigator

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Studying molecular bases of alternative TLR responsesPrincipal Investigator

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Studying innate immune responses to nucleoside stressPrincipal Investigator

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自然免疫応答と脂質代謝の連携分子基盤の解明Principal Investigator

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Novel therapeutic strategies for Sjogren's syndrome targeting Toll-like receptors.

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Understanding a mechanism controlling endogenous retrovirus by Toll-like receptorsPrincipal Investigator

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Cell and Molecular mechanisms underlying the interaction between the innate immune system and metabolism in lysosomesPrincipal Investigator

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リソソームでの核酸認識における核酸代謝系の役割についての研究Principal Investigator

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The role of a transcription factor TFEB in the innate immune systemPrincipal Investigator

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The effect of UV irradiation on development of systemic lupus in mouse model

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Novel regulatory mechanism of TLR7/8 by ssRNAPrincipal Investigator

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Miyake Kensuke 三宅健介

MIYAKE Kensuke 三宅健介