OKANO Yoshiyuki 岡野善行

… Alternative Names

岡野義行オカノヨシユキ

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Researcher Number	60231213
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2012 – 2014: 兵庫医科大学, 医学部, 非常勤講師 2007 – 2011: Osaka City University, 大学院・医学研究科, 講師 2001 – 2005: 大阪市立大学, 大学院・医学研究科, 講師 2003: 大阪市大, 医学(系)研究科(研究院), 講師 2000: 大阪市立大学, 医学部, 講師 1997: Osaka City University Medical School, Associate Professor, 医学部, 講師 1992 – 1996: 大阪市立大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Pediatrics / Pediatrics Except Principal Investigator Pediatrics
Keywords	Principal Investigator グルタメイト脱水素酵素 / 低血糖 / インスリン / アンモニア / 分子遺伝学 / 先天性代謝異常症 / 遺伝子変異 / 高アンモニア血症 / トランスジェニックマウス / 肝臓 … More / 酵素 / 遺伝子 / K_<ATP> channel / mutation / hypoglycemia / hyperammonemia / insulin / glutamate dehydrogenase / K_<ATP>チャンネル / 高インスリン血症 / nonselective cation channel / アデノウィルス / KATPチャンネル / 非選択性陽イオンチャネル / GTP / グルメタイト脱水素酵素 / INHERITED METABOLIC DISEASE / PHENOTYPE / MUTATION / MOLECULAR GENETICS / PHENYLALANINE HYDROXYLASE / PHENYLKETONURIA / 遺伝子解析 / フュニルアラニン水酸化酵素 / 遺伝子発現 / フェニルアラニン水酸化酵素 / フェニルケトン尿症 / 動物モデル / グルタミン酸脱水素酵素 / グルタメト脱水素酵素 … More Except Principal Investigator ELISPOT / 先天性代謝異常症 / 遺伝子変異 / 遺伝子解析 / 遺伝子発現 / ガラクトース血症 / peripheral T lymphocyte / insulin peptide / target antigen / Type 1 diabetes / CD8Tリンパ球 / インスリン / 末梢血Tリンパ球 / 標的抗原 / 1型糖尿病 / inherited Metabolic disease / phenotype / mutation / galactose 1-phosphate uridyltransferase / galactokinase / galactosemia / 常染色性劣性遺伝 / ガラクト・ウリジル・トランスフェラーゼ / ガラクトース-1ーリン酸ウリジルトランスフェラーゼ / ガラクトキナーゼ / Gene Expression / Autosomal Recessive / Mutation / Calactose-1-phosphate uridy, 1 transferase / Inherited metabolic disease / Galactosemia / 常染色体劣性遺伝 / ガラクトース・ウリジル・トランスフェラーゼ / ディファレンシャル□ディスプレー法 / ディファレンシャルディスプレー法 / 未知因子 / 羊膜 / ディファレンシャルディスプレー法 / サブトラクション法 / メカニズム / 分娩発来 Less

Pathophysiological study and the developments of therapy using mouse model of glutamate dehydrogenase disorderPrincipal Investigator
- Principal Investigator
  
  OKANO YOSHIYUKI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Hyogo Medical University
The study of mechanism and approach to treatment for the hyper-ammonemia in the glutamate dehydrogenase abnormalityPrincipal Investigator
- Principal Investigator
  
  OKANO Yoshiyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka City University
The study of mechanism and treatment for the hyperammonemia in the glutamate dehydrogenase abnormalityPrincipal Investigator
- Principal Investigator
  
  OKANO Yoshiyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka City University
Molecular characterization of congenital hyperinsulinism/hyperammonemia caused by glutamate dehydrogenase gene defectsPrincipal Investigator
- Principal Investigator
  
  OKANO Yoshiyuki
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka City University
サブトラクション法を用いたマウス羊膜における分娩発来に関係する未知因子の探索
- Principal Investigator
  
  INADA Hiroshi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Osaka City University
Target Auto-antigens and Pancreatic beta cell destructive T lymphocytes in Type 1 Diabetes
- Principal Investigator
  
  KAWAMURA Tomoyuki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka City University
Molecular characterization of congenital hyperinsulinism/hyperammonemia caused by glutamate dehydrogenase gene defectsPrincipal Investigator
- Principal Investigator
  
  OKANO Yoshiyuki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka City University
Molecular Analysis of Galactosemia
- Principal Investigator
  
  ISSHIKI Gen
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka city University Medical School
Molecular Analysis of Phenylketonuria in East AsiansPrincipal Investigator
- Principal Investigator
  
  OKANO Yoshiyuki
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Osaka City University Medical School
Molecular characteriztion of galactosemia type 1 : the study for gene expression system in autosomal recessive disease
- Principal Investigator
  
  ISSHIKI Gen
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  OSAKA CITY UNIVERSITY

All 2015 2014 2013 2012 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] The importance of molecular diagnosis in the accurate diagnosis of systemic carnitine deficiency2015
- Author(s)
  Hitomi T, Matsuura N, Yosuke Shigematsu S, Okano Y, Shinozaki E, Kawai M, Kobayashi H, Harada K. H. Koizumi K.
- Journal Title
  
  J. Genet
  
  Volume: 94 Pages: 147-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591522
[Journal Article] Changes of lipoproteins in phenylalanine hydroxylase-deficient children for the first early of life.2014
- Author(s)
  Nagasaka H, Tsukahara H, Okano Y, Hirano K, Sakurai T, Hui S-P, Ohura T, Usui H, Yorifuji T, Hirayama S, Ohtake A, Miida T.
- Journal Title
  
  Clin Chim Acta
  
  Volume: 印刷中 Pages: 1-4
- DOI
  10.1016/j.cca.2014.02.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590689, KAKENHI-PROJECT-24591522, KAKENHI-PROJECT-25461594
[Journal Article] Role of per-rectal portal scintigraphy in long-term follow-up of congenital portosystemic shunt.2014
- Author(s)
  Cho Y, Tokuhara D, Shimono T, Yamamoto A, Higashiyama S, Kotani K, Kawabe J, Okano Y, Shiomi S, Shintaku H
- Journal Title
  
  Pediatr Res.
  
  Volume: 75 Pages: 658-662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591522
[Journal Article] Fatigue and quality of life in citrin deficiency during adaptation and compensation stage.2013
- Author(s)
  Okano Y, Kobayashi K, Ihara K, Ito T, Yoshino M, Watanabe Y, Kaji S, Ohura T, Nagao M, Noguchi A, Mushiake S, Hohashi N, Hashimoto-Tamaoki T
- Journal Title
  
  Mol Genet Metab.
  
  Volume: 109(1) Issue: 1 Pages: 9-13
- DOI
  10.1016/j.ymgme.2013.01.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591515, KAKENHI-PROJECT-24591522
[Journal Article] Optimal serum phenylalanine for adult patients with phenylketonuria.2013
- Author(s)
  Okano Y, Nagasaka H.
- Journal Title
  
  Mol Genet Metab
  
  Volume: 110 Issue: 4 Pages: 424-430
- DOI
  10.1016/j.ymgme.2013.09.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591522
[Journal Article] Intractable absence seizures in hyperinsulinism-hyperammonemia syndrome.2012
- Author(s)
  Nakano K, Kobayashi K, Okano Y, Aso K, Ohtsuka Y
- Journal Title
  
  Pediatr Neurol.
  
  Volume: 47 Issue: 2 Pages: 119-122
- DOI
  10.1016/j.pediatrneurol.2012.04.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591522
[Journal Article] Mutation spectrum of and founder effects affecting the PTS gene in East Asian populations.2012
- Author(s)
  Chiu YH, Chang YC, Chang YH, Niu DM, Yang YL, Ye J, Jiang J, Okano Y, Lee DH, Pangkanon S, Kuptanon C, Hock NL, Chiong MA, Cavan BV, Hsiao KJ, Liu TT.:
- Journal Title
  
  J Hum Genet
  
  Volume: 57 Issue: 2 Pages: 145-152
- DOI
  10.1038/jhg.2011.146
- NAID
  10030711780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591522
[Journal Article] Oxysterol changes along with cholesterol and vitamin D changes in adult phenylketonuric patients diagnosed by newborn mass-screening2012
- Author(s)
  Nagasaka Hironori, et al.
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 416 Pages: 54-59
- DOI
  10.1016/j.cca.2012.10.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791008, KAKENHI-PROJECT-23590689, KAKENHI-PROJECT-24591522
[Journal Article] Unregulated insulin secretion by pancreatic beta cells in hyperinsulinism/hyperammonemia syndrome : role of glutamate dehydrogenase, ATP-sensitive potassium channel, and nonselective cation channel.2006
- Author(s)
  Kawajiri M, Okano Y, Kuno M, Tokuhara D, Hase Y, Inada H, Tashiro F, Miyazaki J, Yamano T.
- Journal Title
  
  Pediatr Res 59・3
  
  Pages: 359-364
- Data Source
  KAKENHI-PROJECT-15390687
[Journal Article] Diffusion-weighted MR imaging in patients with phenylketonuria : relationship between serum phenylalanine levels and ADC values in cerebral white matter.2005
- Author(s)
  Kono K, Okano Y, Nakayama K, Hase Y, Minamikawa S, Ozawa N, Yokote H, Inoue Y.
- Journal Title
  
  Radiology. 236・2
  
  Pages: 630-636
- Data Source
  KAKENHI-PROJECT-15390687
[Journal Article] In vivo studies of phenylalanine hydroxylase by phenylalanine breath test : diagnosis of Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency.2004
- Author(s)
  Okano Y
- Journal Title
  
  Pediatr Res 56・6
  
  Pages: 714-719
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390687
[Journal Article] In vivo studies of phenylalanine hydroxylase by phenylalanine breath test : diagnosis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency2004
- Author(s)
  Okano Y
- Journal Title
  
  Pediatr Res 56・6
  
  Pages: 714-719
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390687
[Journal Article] In vivo studies of phenylalanine hydroxylase by phenylalanine breath test : diagnosis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency.2004
- Author(s)
  Okano Y, Hase Y, Kawajiri M, Nishi Y, Inui K, Sakai N, Tanaka Y, Takatori K, Kajiwara M, Yamano T
- Journal Title
  
  Pediatr Res. 56
  
  Pages: 714-719
- Data Source
  KAKENHI-PROJECT-15390687
[Journal Article] Effects of citrin deficiency in the perinatal period : feasibility of newborn mass screening for citrin deficiency.2004
- Author(s)
  Tamamori A, Fujimoto A, Okano Y, Kobayashi K, Saheki T, Tagami Y, Takei H, Shigematsu Y, Hata I, et al.
- Journal Title
  
  Pediatr Res. 56
  
  Pages: 608-614
- Data Source
  KAKENHI-PROJECT-15390687
[Journal Article] Long-term treatment and diagnosis of tetrahydrobiopterin-respomsive hyperphenylalaninemia with a mutant phenylalanine hydroxylase gene2004
- Author(s)
  Shintaku H, Kure S, Ohura T, Okano Y, Ohwada M, Sugiyama N, Sakura N, Yoshida I, Yoshino M, et al.
- Journal Title
  
  Pediatr Res. 55
  
  Pages: 425-430
- Data Source
  KAKENHI-PROJECT-15390687
[Presentation] 高インスリン高アンモニア血症におけるglutamate dehydrogenase活性と遺伝子解析2007
- Author(s)
  麻生和良、岡野善行、中野広輔、坂京子、山野恒一
- Organizer
  日本先天代謝異常学会
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-19591217

1. MIYAZAKI Jyunnichi (10200156)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
2. SAHEKI Takeyori (10056070)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. INADA Hiroshi (00244640)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. KOBAYASHI Keiko (70108869)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. KAWAMURA Tomoyuki (60271186)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. MORITA Takashi (70150349)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ISSHIKI Gen (80046995)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. TANAKA Akemi (30145776)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KUNO Miyuki (00145773)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. ASOU Kazuyoshi

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. TOKUHARA Daisuke (60448751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. NIIHIRA Shizuhiro (50171369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KUDOU Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KAWAJIRI Mie

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TSURUHARA Akifumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. HIRAYAMA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 三井田孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 井原健二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKANO Yoshiyuki 岡野 善行

岡野 義行 オカノ ヨシユキ

Research Projects

Research Products

Co-Researchers

Pathophysiological study and the developments of therapy using mouse model of glutamate dehydrogenase disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of mechanism and approach to treatment for the hyper-ammonemia in the glutamate dehydrogenase abnormalityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of mechanism and treatment for the hyperammonemia in the glutamate dehydrogenase abnormalityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular characterization of congenital hyperinsulinism/hyperammonemia caused by glutamate dehydrogenase gene defectsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

サブトラクション法を用いたマウス羊膜における分娩発来に関係する未知因子の探索

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Target Auto-antigens and Pancreatic beta cell destructive T lymphocytes in Type 1 Diabetes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular characterization of congenital hyperinsulinism/hyperammonemia caused by glutamate dehydrogenase gene defectsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Analysis of Galactosemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Analysis of Phenylketonuria in East AsiansPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular characteriztion of galactosemia type 1 : the study for gene expression system in autosomal recessive disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The importance of molecular diagnosis in the accurate diagnosis of systemic carnitine deficiency2015

Author(s)

Journal Title

Data Source

[Journal Article] Changes of lipoproteins in phenylalanine hydroxylase-deficient children for the first early of life.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of per-rectal portal scintigraphy in long-term follow-up of congenital portosystemic shunt.2014

Author(s)

Journal Title

Data Source

[Journal Article] Fatigue and quality of life in citrin deficiency during adaptation and compensation stage.2013

Author(s)

OKANO Yoshiyuki 岡野善行

岡野義行オカノヨシユキ