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MASUTANI Mitsuko  益谷 美都子

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… Alternative Names

益谷 美都子  マスタニ ミツコ

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Researcher Number 60238904
Other IDs
External Links
Affiliation (Current) 2022: 長崎大学, 医歯薬学総合研究科(医学系), 教授
2022: 国立研究開発法人国立がん研究センター, 研究所, 客員研究員
Affiliation (based on the past Project Information) *help 2015 – 2021: 長崎大学, 医歯薬学総合研究科(医学系), 教授
2017: 長崎大学, 大学院医歯薬学総合研究科・フロンティア生命科学分野, 教授
2016: 独立行政法人国立がん研究センター, ゲノム安定性研究分野, 分野長
2016: 長崎大学, 大学院医歯薬総合研究科, 教授
2014: 独立行政法人国立がん研究センター, その他部局等, その他 … More
2014: 独立行政法人国立がん研究センター, その他部局等, 客員研究員
2014: 国立がん研究センター研究所, ゲノム安定性研究分野, 分野長
2014: 長崎大学大学院医歯薬学総合研究科, 生命医科学講座フロンティア生命科学分野, 教授
2010 – 2013: 独立行政法人国立がん研究センター, 研究所, 分野長
2011: 国立がん研究センター研究所, ゲノム安定性研究分野, 分野長
2004: 国立がんセンター(研究所), 生化学部・担がん生体研究室, 室長
2003: 国立がんセンター研究所, 生化学部・担がん生体研究室室長
2001: 国立がんセンター研究所, 生化学部・担がん生体研究室, 室長
2000: 国立がんセンター, 生化学部・担がん生体・研究室, 室長
1998: 国立がんセンター, 研究所 生化学部, 室長
1994 – 1996: 国立がんセンター研究所, 生化学部, 研究員
1993: 国立がんセンター研究所, 生化学, 研究員 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Cell biology / Clinical oncology / Tumor diagnosis / Tumor therapeutics / Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Surgical dentistry / Risk sciences of radiation and chemicals / Dental engineering/Regenerative dentistry
Keywords
Principal Investigator
ガンマ線 / ポリ(ADP-リボース)合成酵素 / Parp / NAD / DNA損傷 / STGC / 胚細胞腫瘍 / ES cell / apoptosis / ポリ(ADP-リボース) … More / PARP / gamma-irradiation / cancer / DNMT3b / BALB / C3T3 A31-1-1 / G1 arrest / mdm-2 / Cdk4 / Irf-1 / 細胞周期停止 / 3-アミノベンズアミド / p53タンパク質 / MDM-2 / WAF1 / C1P1 / P21 / G1期停止 / CIP1 / p21 / ノックアウトマウス / methvl methanesulfonate / streptozotocin / 糖尿病 / 細胞死 / Vegf / trophoblast / differentiation / spongiotrophoblast / 合胞体性巨細胞 / proliferin / Poly(ADP-ribose) / Parg / ポリ(ADP-リボース)グリコヒドロラーゼ / ribosyl adenosine / ribosyl inosine / ES細胞 / PARG / PARP1 / knockdown / gamma irradiation / 放射線 / アルキル化剤 / 合成致死 / epigenetic / PARP-1 / 代謝物 / リボシルアデノシン / リボシルイノシン / 血液 / 尿 / マウス / radiosensitization / 放射線感受性 / 網羅的探索 / 放射線増感 / PARP阻害剤 / 陽子線 / DNMT3B / HP1beta / gamma H2AX / BNCT / バイオマーカー / DAMPs / 中性子線 … More
Except Principal Investigator
ポリADP-リボシル化 / 再生医療 / 再生医学 / 脱リン酸化 / c-myb / ロイシンジッパー / 再生歯学 / ポリADP-リボシル化反応 / ノックアウトマウス / 象牙芽細胞 / 歯髄 / ポリADP-リボース合成酵素 / 歯科 / 多能性 / リプログラミング / 口腔癌 / 分子標的薬 / 口腔がん / 化学療法 / 放射線療法 / DNA損傷トレランス / 複製後修復 / 組換え修復 / ユビキチン / 相同組換え / DNA修復 / DNAヘリカーゼ / 生殖幹細胞 / 放射線 / 化学物質 / ゲノム安定性 / ショウジョウバエ / 生殖細胞 / 精子形成 / RecQ / ゲノム / 分子生物学 / 幹細胞 / エクソソーム / microRNA / 次世代シークエンス / miRNA / 細胞外RNA / 機能性RNA Less
  • Research Projects

    (17 results)
  • Research Products

    (63 results)
  • Co-Researchers

    (36 People)
  •  BNCTにおける治療局所・全身性応答と治療奏効性、副作用のバイオマーカーの同定Principal Investigator

    • Principal Investigator
      益谷 美都子
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Nagasaki University
  •  A comprehensive genome-wide screen of radiosensitization targetsPrincipal Investigator

    • Principal Investigator
      MASUTANI Mitsuko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor therapeutics
    • Research Institution
      Nagasaki University
  •  Study on characteristics of small RNA secreted from the pluripotent stem cells

    • Principal Investigator
      NOZAKI Tadashige
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Osaka Dental University
  •  genome stability in germ-line stem cells to irradiation and exposure to chemicals

    • Principal Investigator
      kawasaki katsumi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      Setsunan University
  •  Analysis of DNA-damage-tolerance mechanisms that facilitate restart of stalled DNA replication

    • Principal Investigator
      MOTEGI AKIRA
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      Kyoto University
  •  Study on mechanisms for reprogramming factors inducing pluripotency

    • Principal Investigator
      NOZAKI Tadashige
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Osaka Dental University
  •  Basic research for therapeutic indication of new molecular target drug for oral carcinoma

    • Principal Investigator
      FUJIHARA Hisako
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Tsurumi Junior College
      Tsurumi University
  •  Research for development of biomarkers for radiation therapy and chemotherapyPrincipal Investigator

    • Principal Investigator
      MASUTANI Mitsuko
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor diagnosis
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Research for poly(ADP-ribosylation) as a potential cancer therapeutic targetPrincipal Investigator

    • Principal Investigator
      MASUTANI MITSUKO
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Clinical oncology
    • Research Institution
      National Cancer Center Japan
  •  The investication of factors related to odontoblast diffenetiation and morphology preservation, and analysis of expression

    • Principal Investigator
      FUJIHARA Hisako
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dental engineering/Regenerative dentistry
    • Research Institution
      Tsurumi University
  •  個体・細胞レベルでの放射線応答へのポリ(ADP-リボース)代謝の関与と放射線増感Principal Investigator

    • Principal Investigator
      益谷 美都子
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  個体・細胞レベルでの放射線応答へのポリ(ADP-リボース)代謝の関与と放射線増感Principal Investigator

    • Principal Investigator
      益谷 美都子
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  胚細胞腫瘍における合胞体性巨細胞(STGC)の出現機構とその役割Principal Investigator

    • Principal Investigator
      益谷 美都子
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  胚細胞腫瘍における合胞体性巨細胞(STGC)の出現機構とその制御Principal Investigator

    • Principal Investigator
      益谷 美都子
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  ポリ(ADP-リボース)合成酵素欠損細胞及びマウスを用いたDNA修復機構の研究Principal Investigator

    • Principal Investigator
      益谷 美都子
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  DNA障害時の細胞周期停止をアポトーシスの制御へのポリADP-リボースの関与Principal Investigator

    • Principal Investigator
      益谷 美都子
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  腫瘍細胞のDNA機能異常における核タンパク質の相互作用

    • Principal Investigator
      三輪 正直
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      University of Tsukuba

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2005 2004 Other

All Journal Article Presentation Book Patent

  • [Book] PARP Inhibitors for Cancer Therapy Cancer Drug Discovery and Development2015

    • Author(s)
      Junhui Wang, Akira Sato, Hiroaki Fujimori, Yoshio Miki, Mitsuko Masutani
    • Publisher
      Springer, New York
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Book] Role of poly-ADP-ribosylation in cancer development. In : Poly(ADP-Ribosyl)ation

    • Author(s)
      Masutani M, et al.
    • Publisher
      Buerkle A.(Eurekah.Com.)(In press)
    • Data Source
      KAKENHI-PROJECT-16023271
  • [Journal Article] Next-generation sequencing-based miRNA expression analysis in Parp1 -deficient embryonic stem cell-derived exosomes2018

    • Author(s)
      Nozaki Tadashige、Sasaki Yuka、Fukuda Itsuko、Isumi Mayu、Nakamoto Keitaro、Onodera Takae、Masutani Mitsuko
    • Journal Title

      Biochemical and biophysical research communications

      Volume: 499 Pages: 410-415

    • DOI

      10.1016/j.bbrc.2018.03.073

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K11283, KAKENHI-PROJECT-17H01911, KAKENHI-PROJECT-19K21286
  • [Journal Article] PARP阻害剤2017

    • Author(s)
      佐々木 由香、小野寺 貴恵、河知 あすか、下村 昭彦、田村 研治、益谷 美都子.
    • Journal Title

      腫瘍内科

      Volume: 4 Pages: 447-453

    • Data Source
      KAKENHI-PROJECT-15K14416
  • [Journal Article] Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors2016

    • Author(s)
      Wang J, Ding Q, Fujimori H, Motegi A, Miki Y, Masutani M.
    • Journal Title

      Oncotarget

      Volume: 7 Pages: 7701-7714

    • DOI

      10.18632/oncotarget.6715

    • NAID

      120005820856

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H04693, KAKENHI-PROJECT-25340030, KAKENHI-PROJECT-15K14394
  • [Journal Article] Parp1 deficiency confers defects in chromatin surveillance and remodeling during reprogramming by nuclear transfer2016

    • Author(s)
      Tomoharu Osada, Tadashige Nozaki, Mitsuko Masutani
    • Journal Title

      Current Protein and Peptide Science

      Volume: 17

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K11283
  • [Journal Article] Radiosensitization by PARP inhibition to proton beam irradiation in cancer cells.2016

    • Author(s)
      Hirai T, Saito S, Fujimori H, Matsushita K, Nishio T, Okayasu R, Masutani M
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 478 Pages: 234-240

    • DOI

      10.1016/j.bbrc.2016.07.062

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K14416
  • [Journal Article] A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage responses2015

    • Author(s)
      Fujimori H, Sato A, Kikuhara S, Junhui W, Hirai T, Sasaki Y, Murakami Y, Okayasu R, Masutani M.
    • Journal Title

      Sci Rep. 2015 Dec 15;5:18231.

      Volume: on-line paper Pages: 18231-18231

    • DOI

      10.1038/srep18231

    • NAID

      120006987240

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06890, KAKENHI-PROJECT-26460310, KAKENHI-PROJECT-15K14416, KAKENHI-PROJECT-24249067
  • [Journal Article] Design and synthesis of phenolic hydrazide hydrazones as potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors.2014

    • Author(s)
      Islam R, Koizumi F, Kodera Y, Inoue K, Okawara T, Masutani M.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 15 Pages: 3802-3806

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Journal Article] ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells.2014

    • Author(s)
      Roper SJ, Chrysanthou S, Senner CE, Sienerth A, Gnan S, Murray A, Masutani M, Latos P, Hemberger M.
    • Journal Title

      Nucleic Acids Res.

      Volume: 42 Pages: 8914-8927

    • DOI

      10.1093/nar/gku591

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Journal Article] Poly(ADP-ribosylation) in carcinogenesis.2013

    • Author(s)
      Masutani M, Fujimori H.
    • Journal Title

      Molecular Aspects of Medicine

      Volume: 34 Pages: 1202-1216

    • DOI

      10.1016/j.mam.2013.05.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Journal Article] The H19 induction triggers trophoblast lineage commitment in mouse ES cells.2013

    • Author(s)
      Fujimori H, Mukai H, Murakami Y, Hemberger M, Hippo Y, Masutani M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 436 Pages: 313-318

    • DOI

      10.1016/j.bbrc.2013.05.100

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Journal Article] Rapid degradation of poly(ADP-ribose) after injection into the mouse bloodstream.2013

    • Author(s)
      Okajima Y, Yoshida T, Fujimori H, Wang J, Harada H, Suzuki Y, Suzuki H, Masutani M.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 36 Pages: 462-466

    • NAID

      130003382078

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24650640
  • [Journal Article] Arf/p53 module, which induces apoptosis, downregulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs.2013

    • Author(s)
      Yuko Atsumi, Aki lnase, Eiji Sugihara, Ryo Sakasai, Hiroaki Fujimori, Hirobumi Teraoka, Hideyuki Saya, Masamoto Kanno, Fumio Tashiro, Hitoshi Nakagami, Mitsuko Masutani, Ken-ichi Yoshioka
    • Journal Title

      J Biol Chem

      Volume: 288巻 Pages: 13269-13277

    • DOI

      10.1074/jbc.m112.402560

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J10618, KAKENHI-PROJECT-22300343, KAKENHI-PROJECT-23501271, KAKENHI-PROJECT-23616003, KAKENHI-PROJECT-25860245
  • [Journal Article] Rapid degradation of poly(ADP-ribose) after injection into the mouse bloodstream2013

    • Author(s)
      Yasuhisa Okajima, Tomoko Yoshida, Hiroaki Fujimori, Junhui Wang, Hiromi Harada, Ylenia Suzuki, Hisanori Suzuki, Mitsuko Masutani
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 36(3) Pages: 462-6

    • NAID

      130003382078

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24650640
  • [Journal Article] PARP阻害剤: がん治療における合成致死と増感剤としての役割2013

    • Author(s)
      平井崇久、笹井啓資、益谷 美都子
    • Journal Title

      放射線生物研究 Radiation Biology Research Communications

      Volume: 48 Pages: 52-65

    • NAID

      40019645305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Journal Article] Poly(ADP-ribosylation) regulates chromatin organization through histone H3 modification and DNA methylation of the first cell cycle of mouse embryos.2013

    • Author(s)
      Osada T, Ryden AM, Masutani M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 434 Pages: 15-21

    • DOI

      10.1016/j.bbrc.2013.03.074

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Journal Article] Parg deficiency confers radio-sensitization through enhanced cell death in mouse ES cells exposed to various forms of ionizing radiation.2013

    • Author(s)
      Shirai H, Fujimori H, Gunji A, Maeda D, Hirai T, Poetsch AR, Harada H, Yoshida T, Sasai K, Okayasu R, Masutani M.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: Epub ahead of print Pages: 100-106

    • DOI

      10.1016/j.bbrc.2013.04.048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300343, KAKENHI-PROJECT-24249067, KAKENHI-PROJECT-24890233
  • [Journal Article] Parp-1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment2013

    • Author(s)
      Nozaki T, Fujimori H, Wang J, Suzuki H, Imai H, Watanabe M, Ohura K, Masutani M
    • Journal Title

      Pathology International

      Volume: 63 Pages: 408-414

    • DOI

      10.1111/pin.12086

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24593020
  • [Journal Article] Poly(ADP-ribose) glycohydrolase deficiency sensitizes mouse ES cells to particular types of DNA damaging agents2009

    • Author(s)
      Fujihara H, Ogino H, Maeda D, Shirai H, Nozaki T, Kamada N, Jishage K, Tanuma S, Takato T, Nakagama H, Sugimura T, Masutani M
    • Journal Title

      Curr Cancer Drug Target

      Volume: 9(8) Pages: 953-962

    • Data Source
      KAKENHI-PROJECT-21592491
  • [Journal Article] Genetic alteration of poly(ADP-ribose)polymerase-1 in human germ cell tumors.2005

    • Author(s)
      Shiokawa M, Masutani M, et al.
    • Journal Title

      Jpn.J.Clin.Oncol. 35

      Pages: 97-102

    • Data Source
      KAKENHI-PROJECT-16023271
  • [Journal Article] Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent.2005

    • Author(s)
      Shibata A, Masutani M, et al.
    • Journal Title

      Oncogene 24

      Pages: 1328-1337

    • Data Source
      KAKENHI-PROJECT-16023271
  • [Journal Article] Stability of centrosome numbers in poly(ADP-ribose) polymerase^<-/->and poly(ADP-ribose) glycohydrolase-deficient mouse ES cells.2004

    • Author(s)
      Ogino H, Masutani M, et al.
    • Journal Title

      Proc.Japan Acad. Ser.B80

      Pages: 290-294

    • Data Source
      KAKENHI-PROJECT-16023271
  • [Journal Article] Poly(ADP-ribose) polymerase-1 inhibits ATM kinase activity in DNA damage response.2004

    • Author(s)
      Watanabe F, Masutani M, et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 319

      Pages: 596-602

    • Data Source
      KAKENHI-PROJECT-16023271
  • [Journal Article] In situ analysis of repair processes for oxidative DNA damage in mammalian cells.2004

    • Author(s)
      Lan L, Masutani M, et al.
    • Journal Title

      Proc.Natl.Acad.Sci., USA 101

      Pages: 13738-13743

    • Data Source
      KAKENHI-PROJECT-16023271
  • [Journal Article] PolyADP-ribosylation in relation to cancer and auto-immune diseases.

    • Author(s)
      Masutani M, et al.
    • Journal Title

      CMLS, Cell.Mol.Life Sci. In press

    • Data Source
      KAKENHI-PROJECT-16023271
  • [Patent] ポリ(ADP-リボース)代謝のバイオマーカーとしてリボシルアテノシンおよびリボシルイノシン2005

    • Inventor(s)
      益谷 美都子, 吉田 智子, 中釜 斉
    • Industrial Property Rights Holder
      国立がんセンター
    • Filing Date
      2005-03-02
    • Data Source
      KAKENHI-PROJECT-16023271
  • [Presentation] 放射線増感標的としてのIL27RA2017

    • Author(s)
      小野寺貴恵, 菊原颯太, 藤森浩彰, 佐々木由香, 今道祥二, 村上康文, 益谷 美都子
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-15K14416
  • [Presentation] APOBEC3Gの発現抑制による放射線増感検証と作用機序の解析2017

    • Author(s)
      小野寺貴恵, 菊原颯太, 藤森浩彰, 佐々木由香, 今道祥二, 村上康文, 益谷美都子
    • Organizer
      生命科学系学会合同年次大会(ConBio2017)
    • Data Source
      KAKENHI-PROJECT-15K14416
  • [Presentation] ES細胞由来エクソソームmiRNAを介したシグナル伝達におけるParp1の関与2017

    • Author(s)
      野崎中成、益谷美都子、大浦 清
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2017-03-07
    • Data Source
      KAKENHI-PROJECT-15K11283
  • [Presentation] Biological research for optimization of radiation therapy2017

    • Author(s)
      Mitsuko Masutani
    • Organizer
      長崎大学-ヴュルツブルク大学合同 第二回シンポジウム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K14416
  • [Presentation] NGS-based analysis of exosomes from Parp1-deficient ES cells2017

    • Author(s)
      Nozaki Tadashige、Masutani Mitsuko、Ohura Kiyoshi
    • Organizer
      FDI's Annual World Dental Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K11283
  • [Presentation] Profiling of small RNAs in exosomes secreted from Parp1 knockout embryonic stem cells2017

    • Author(s)
      野崎中成、益谷美都子、大浦 清
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール、長崎新聞文化ホール アストピア(長崎市)
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-15K11283
  • [Presentation] Comprehensive miRNA expression analysis in exosomes derived from Parp1-deficient embryonic stem cells using next-generation sequencing2016

    • Author(s)
      Tadashige Nozaki, Hiroaki Fujimori, Mitsuko Masutani, Kiyoshi Ohura
    • Organizer
      the 7th EMBO meeting
    • Place of Presentation
      The Rosengarten Conference Centre (Mannheim, Germany)
    • Year and Date
      2016-09-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K11283
  • [Presentation] CtIP is a novel biomarker for predicting the sensitivity of breast cancers to PARP inhibitors2016

    • Author(s)
      Akira Motegi,Junhui Wang, Hiroaki Fujimori, Yoshio Miki, and Mitsuko Masutani
    • Organizer
      The 2nd RBC-CEA Joint Workshop
    • Place of Presentation
      京都大学 (京都市)
    • Year and Date
      2016-04-11
    • Data Source
      KAKENHI-PROJECT-25340030
  • [Presentation] IL27RAの機能阻害による放射線感受性の増感作用.2016

    • Author(s)
      小野寺貴恵, 菊原颯太, 藤森浩彰, 佐々木由香, 今道祥二, 村上康文, 益谷美都子
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川県横浜市
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K14416
  • [Presentation] PARP-1 and PARG promote genomic integrity by regulating resection of DNA double-strand breaks2015

    • Author(s)
      Akira Motegi,Junhui Wang, Hiroaki Fujimori, Yoshio Miki, and Mitsuko Masutani
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-12-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-25340030
  • [Presentation] PARP-1 and PARG regulate 53BP1 to control DNA end resection2015

    • Author(s)
      Junhui Wang, Akira Motegi, Hiroaki Fujimori, Yoshio Miki, and Mitsuko Masutani
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-25340030
  • [Presentation] PARP-1は、Dnmt3 promoterの制御因子として機能する2014

    • Author(s)
      藤森浩彰、向井大晃、平井崇久、原田博美、工藤祐子、村上康文、渡邉昌俊、益谷美都子
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都市
    • Year and Date
      2014-10-15
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Presentation] 口腔癌由来細胞に対する化学療法におけるポリADP-リボース合成酵素(PARP)阻害剤の効果2014

    • Author(s)
      安川 仁章, 藤原 久子, 岸 悠太, 山本 那々美, 山田浩之, 川口 浩司, 里村一人, 益谷美都子, 濱田 良樹
    • Organizer
      第33回分子病理研究会
    • Place of Presentation
      宮城蔵王ロイヤルホテル(宮城県)
    • Data Source
      KAKENHI-PROJECT-24593041
  • [Presentation] 創薬の基盤としてのADP-リボシル化の生化学2014

    • Author(s)
      益谷美都子、藤森浩彰、原田博美、光畑元晴、高村 岳樹
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都市
    • Year and Date
      2014-10-15
    • Invited
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Presentation] Identification of ribosyladenosine and ribosylinosine as specific metabolites of poly(ADP-ribose)2013

    • Author(s)
      Mitsuko Masutani, Hiroaki Fujimori, Tomoko Yoshida, Hiromi Harada, Motoharu Kohata, Takeji Takamura-Enya
    • Organizer
      blood and urine. PARP2013
    • Place of Presentation
      Quebec City(プログラム, (巻号なし) p93, 2013)
    • Data Source
      KAKENHI-PROJECT-24650640
  • [Presentation] Identification of ribosyladenosine and ribosylinosine as specific metabolites of poly(ADP-ribose) in blood and urine.2013

    • Author(s)
      Mitsuko Masutani, Hiroaki Fujimori, Tomoko Yoshida, Hiromi Harada, Motoharu Kohata, Takeji Takamura-Enya
    • Organizer
      PARP2013
    • Place of Presentation
      Quebec City, Canada
    • Data Source
      KAKENHI-PROJECT-24650640
  • [Presentation] PARP-1 suppresses the end-resection of 5'- and 3'-blocked termini of double-strand DNA breaks by CtIP2013

    • Author(s)
      Junhui Wang, Akira Motegi, HIroaki Fujimori, Yoshio Miki, Mitsuko Masutani
    • Organizer
      The 72nd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-25340030
  • [Presentation] Poly(ADP-ribose) formation/metabolism after DNA damage (DNA 損傷後のpoly(ADP-ribose)の動態の検討2013

    • Author(s)
      Hiromi Harada, Miyuki Hozumi, Hiroaki Fujimori, Takahisa Hirai, Soichiro Saito, Yasufumi Murakami, Mitsuko Masutani
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      神奈川県 横浜市  パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Presentation] Biological radiosensitization by PARP inhibitors2013

    • Author(s)
      Mitsuko Masutani, Takahisa Hirai, Hiroaki Fujimori, Souichiro Saito, Teiji Nishio, Ryuichi Okayasu, Akira Fujimori, Keisuke Sasai
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      神奈川県 横浜市  パシフィコ横浜
    • Invited
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Presentation] PARP-1 suppresses the end-resection of 5’- and 3’-blocked termini of double-strand DNA breaks by CtIP2013

    • Author(s)
      Junhui Wang, Akira Motegi, Hiroaki Fujimori, Yoshio Miki, Mitsuko Masutani
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      神奈川県 横浜市  パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Presentation] Radio-sensitization by Parg deficiency in mouse ES cells exposed to low and high LET radiation.2012

    • Author(s)
      Hidenori Shirai, Takahisa Hirai, Keisuke Sasai2 Ryuichi Okayasu, Mitsuko Masutani
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Presentation] PARG機能阻害によるがん細胞株におけるアルキル化剤に対する致死感受性亢進2012

    • Author(s)
      藤森浩彰、向井大晃、村上康文、益谷美都子
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡市
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Presentation] PARG機能阻害によるがん細胞株におけるアルキル化剤に対する致死感受性亢進2012

    • Author(s)
      白井秀徳 藤森浩彰 岡島泰久 益谷美都子
    • Organizer
      第16回日本がん分子標的治療学会学術集会
    • Place of Presentation
      北九州市
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Presentation] Rapid degradation of poly(ADP-ribose) after injection into the mouse bloodstream2012

    • Author(s)
      Hiromi Harada, Yasuhisa Okajima, Tomoko Yoshida, Hiroaki Fujimori, Mitsuko Masutani
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-12-15
    • Data Source
      KAKENHI-PROJECT-24650640
  • [Presentation] Rapid degradation of poly(ADP-ribose) after injection into the mouse bloodstream.2012

    • Author(s)
      Hiromi Harada, Yasuhisa Okajima, Tomoko Yoshida, Hiroaki Fujimori, Mitsuko Masutani.
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡市
    • Data Source
      KAKENHI-PROJECT-24650640
  • [Presentation] PARP阻害剤の抗がん剤としての作用機構2011

    • Author(s)
      益谷美都子, 他3名
    • Organizer
      第15回学術集会日本がん分子標的治療学会学術集会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-06-24
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Presentation] PARPの機能と抗がん剤としてのPARP阻害剤の作用機序2011

    • Author(s)
      益谷美都子
    • Organizer
      遺伝医学合同学術集会2011シンポジウム
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2011-06-17
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Presentation] Involvement of poly(ADP-ribose) polymerase-1(Parp-1) in odontogenic function2010

    • Author(s)
      Fujihara H., Hamada Y., Tsutsumi M., Kusuoka O., Sugimura T., Masutani M
    • Organizer
      88th IADR General Session
    • Place of Presentation
      Barcelona
    • Data Source
      KAKENHI-PROJECT-21592491
  • [Presentation] Involvement of poly(ADP-ribose) polymerase-1(Parp-1) in odontoblast differentiation in aging process2010

    • Author(s)
      Fujihara H., Tsutsumi M., Kusuoka O., Hamada Y., Sugimura T., Masutani M
    • Organizer
      18th International Conference on ADP-ribose metabolism
    • Place of Presentation
      Zurich
    • Data Source
      KAKENHI-PROJECT-21592491
  • [Presentation] Involvement of poly(ADP-ribose) polymerase-1 (Parp-1) in odontoblast differentiation in aging process.2010

    • Author(s)
      Fujihara H., Masutani, et al.
    • Organizer
      18^<th> International Conference on ADP-ribose metabolism
    • Place of Presentation
      Zurich
    • Data Source
      KAKENHI-PROJECT-21592491
  • [Presentation] Effect of Parp-1 deficiency on trophoblast differentiation of ES cells after injection into the uterus

    • Author(s)
      Nozaki T, Fujimori H, Suzuki H, Watanabe M, Ohura K, Masutani M.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡(福岡市)
    • Data Source
      KAKENHI-PROJECT-24593020
  • [Presentation] 異所性骨形成誘導のモデルマウスを用いた解析

    • Author(s)
      益谷美都子、野崎中成、荻野秀樹、藤森浩彰、藤原久子、大浦 清
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Data Source
      KAKENHI-PROJECT-24593020
  • [Presentation] PARP-1 and PARG are both required for the regulation of 53BP1 after IR

    • Author(s)
      Junhui Wang, Akira Motegi, Hiroaki Fujimori, Yoshio Miki, Mitsuko Masutani
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-22300343
  • [Presentation] PARP-1 and PARG are both required for the regulation of 53BP1 after IR

    • Author(s)
      Junhui Wang, Akira Motegi, Hiroaki Fujimori, Yoshio Miki, and Mitsuko Masutani
    • Organizer
      The 73rd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-25340030
  • [Presentation] 口腔がん由来細胞に対する化学療法におけるポリADP-リボース合成酵素 (PARP)阻害剤の効果

    • Author(s)
      安川 仁章、 藤原 久子、 岸 悠太、 山本 那々美、 山田 浩之、川口 浩司、 里村 一人、 益谷 美都子、 濱田 良樹
    • Organizer
      分子病理学研究会
    • Place of Presentation
      宮城蔵王ロイヤルホテル(宮城県刈田郡)
    • Year and Date
      2014-07-25 – 2014-07-26
    • Data Source
      KAKENHI-PROJECT-24593041
  • [Presentation] Parp-1 deficiency in ES cells induces trophoblast giant cells, tumor growth reduction, and metastatic lesions during teratocarcinoma formation after injection into the uterus

    • Author(s)
      Nozaki T, Fujimori H, Suzuki H, Watanabe M, Ohura K, Masutani M.
    • Organizer
      The EMBO Meeting 2012
    • Place of Presentation
      Nice Acropolis (France)
    • Data Source
      KAKENHI-PROJECT-24593020
  • 1.  NOZAKI Tadashige (90281683)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 10 results
  • 2.  FUJIHARA Hisako (80396746)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 3.  FUJIMORI Hiroaki (00590043)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 18 results
  • 4.  HOSHI Kazuto (30344451)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  IINO Mitsuyoshi (50212717)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  CHIKAZU Daichi (30343122)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  FUJIHARA Yuko (50466744)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 8.  TAKATO Tsuyoshi (90171454)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  OKAYASU Ryuichi (50356135)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 10.  YAMADA Hiroyuki (90267542)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  HORIUCHI Toshikatsu (90454165)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TAKAMURA Takeji (50342910)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 13.  MOTEGI AKIRA (80452332)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 14.  kawasaki katsumi (60177665)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  KOBAYASHI Junya (30301302)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  三輪 正直 (20012750)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  谷口 武利 (90127944)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  長尾 美奈子 (40100151)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  上田 國寛 (00027070)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  石井 俊輔 (00124785)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  新井 剛 (80454164)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  長田 武 (70411709)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  吉岡 泰秀 (40572839)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  ONODERA Takae
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 25.  SASAKI Yuka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 26.  HIRAI Takahisa
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 27.  IMAMICHI Shoji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 28.  KIKUHARA Sota
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 29.  TASHIRO Fumio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  SATO Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  FUKUDA Itsuko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  菅野 雅元
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  杉原 英志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  三木 義男
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  藤森 亮
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 36.  崔 星
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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