Mori Takashi 森隆

… Alternative Names

森隆モリタカシ

MORI Takashi 森隆

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Researcher Number	60239605
Other IDs
Affiliation (Current)	2025: 埼玉医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 埼玉医科大学, 医学部, 教授 2015 – 2017: 埼玉医科大学, 医学部, 教授 2007 – 2014: Saitama Medical University, School of Medicine, Associate Professor 2004 – 2006: Saitama Medical school, Medicine, Associate professor, 医学部, 助教授 2002 – 2003: 埼玉医科大学, 医学部, 講師 2002: 埼玉大学, 医学部, 講師 1994 – 1996: 日本医科大学, 老人病研究所, 助手
Review Section/Research Field	Principal Investigator Cerebral neurosurgery / Basic Section 46020:Anatomy and histopathology of nervous system-related / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology Except Principal Investigator Biological Sciences / Nerve anatomy/Neuropathology / Basic Section 49020:Human pathology-related / Gastroenterology / Cerebral neurosurgery
Keywords	Principal Investigator 遺伝子改変マウス / アミロイドβ蛋白 / アルツハイマー病 / 神経病理学 / フリーラジカル / 遅発性脳血管攣縮 / アポリポプロテインE / フェノール化合物 / 獣医学 / 細胞・組織 … More / 神経科学 / superoxide anion / 炎症反応 / ペプチド / アミロイド前駆体蛋白 / Astrocyte / Isoform specific / Knock-in mouse / subacute cerebral ischemia / Acute / Apolipoprotein E / 急性期脳虚血 / アストロサイト / アイソフォーム特異的 / ノックインマウス / 急性期・亜急性期脳虚血 / アポリポプロテイン E / 行動機能 / 認知機能 / シナプス関連蛋白 / 抗酸化効果 / 抗炎症効果 / ポリフェノール / 神経変性疾患 / 病理学 / 脳神経疾患 / 脳神経変性疾患 / DNA断片化 / apoptosis / SOD / diaminobenzidine-tetrahydrochrorid / Mnイオン / superoxide dismutase / 生体防御機構 … More Except Principal Investigator アルツハイマー病 / 痴呆 / アミロイド / S-100 / 認知症 / βアミロイド / 脳神経疾患 / 神経科学 / βタンパク / 診断法 / リンパ腫 / lymphoma / BCL2 / Burkitt / HGBL / Burkittリンパ腫 / MYC / 高悪性度B細胞リンパ腫 / Burkitt lymphoma / DLBCL / Amyotrophic lateral sclerosis / Acute lung injury / Transplantation / Aminoglycoside / Apoptosis / Protein therapy / renerfusion / Ischemia / Drug-induced liver injury / Bcl-x / Ptortein transduction domain / 四塩化炭素 / 薬物性急性肝炎 / bcl-x / 肝臓 / Protein transduction domain / ネクローシス / 肺傷害 / 抗癌剤 / ミトコンドリア / 筋萎縮性側索硬化症 / 急性肺障害 / 移植 / アミノグリコシド / アポトーシス / 蛋白質治療 / 虚血再灌流傷害 / 薬物性肝炎 / dementia / apolipoprotein E / cholesterol / lipid raft / amyloid β protein / Alzheimer's disease / アポリポ蛋白E / コレステロール / 脂質ラフト / Astrocyte / Rat / Permanent focal cerebral ischemia / Cerebral Ischemia / 永久局所脳虚血モデル / アストロサイト / S-100蛋白 / 永久脳虚血モデル / アストロサイ / ラット / 永久局所脳虚血 / 脳虚血 / 老化性痴呆疾患 / ganglioside / ガングリオシド / APP / タンニン酸 / ポリフェノール / Alzheimer病 / BACE / Herp Less

Targeting apolipoprotein E for Alzheimer's disease therapy.Principal Investigator
- Principal Investigator
  
  森隆
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Saitama Medical University
Screening strategy of High grade B-cell lymphoma
- Principal Investigator
  
  Momose Shuji
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Saitama Medical University
Alzheimer's disease: Exploration of combination therapy with food-derived amyloid-beta peptide modulators and environmental therapy.Principal Investigator
- Principal Investigator
  
  MORI TAKASHI
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Saitama Medical University
Development of a new therapeutic strategy for Alzheimer's disease: Exploration of amyloid-beta inhibitors derived from foods and environment enrichment therapy.Principal Investigator
- Principal Investigator
  
  MORI TAKASHI
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Saitama Medical University
Pathology of the Alzheimer disease : prevention of cerebral β-amyloid deposition
- Principal Investigator
  
  YAMAGUCHI Haruyasu
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Gunma University
Possible role of glial cells in the progression of Alzheimer's disease pathologyPrincipal Investigator
- Principal Investigator
  
  MORI Takashi
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Saitama Medical University
Inhibition of liver degeneration by protein transduction method using the super anti-cell death protein
- Principal Investigator
  
  AOSH Sadamitsu
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nippon Medical School
アルツハイマー病モデル動物脳を用いた脳病変進展過程の検討
- Principal Investigator
  
  山口晴保
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
Research on cerebral beta-amyloid deposition and neurodegeneration related to lipid metabolism of the plasma membrane.
- Principal Investigator
  
  YAMAGUCHI Haruyasu
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Gunma University
動物脳を用いた脳アルツハイマー病変進展過程の検討
- Principal Investigator
  
  山口晴保
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
動物モデルを用いた脳アルツハイマー病変進展過程の検討
- Principal Investigator
  
  YAMAGUCHI Haruyasu
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
Comparison of apolipoprotein E isoform-specific effects after experimental cerebral ischemia.Principal Investigator
- Principal Investigator
  
  MORI Takashi
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Saitama Medical School
Possible role of astrocytes in the disease progression of experimental cerebral ischemia
- Principal Investigator
  
  ASANO Takao
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Saitama Medical University
脳血管攣縮に於けるsuperoxide anionの関与と細胞障害機序の解明Principal Investigator
- Principal Investigator
  
  森隆
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Nippon Medical School
遅発性脳血管攣縮病態下での攣縮動脈周囲のsuperoxide anionの局在Principal Investigator
- Principal Investigator
  
  森隆
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Nippon Medical School
遅発性脳血管攣縮の病理発生における炎症反応の関与の可能性に関する研究Principal Investigator
- Principal Investigator
  
  森隆
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Nippon Medical School

[Book] A naturally-occurring β-secretase modulator, tannic acid, improves behavioral impairment and mitigates Alzheimer-like pathology. In Diet and Nutrition in Dementia and Cognitive Decline, (Martin C and Preedy V ed.)2014
- Author(s)
  Takashi Mori, Terrence Town
- Total Pages
  300
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-22500320
[Book] A naturally-occurringβ-secretase modulator, tannic acid, improves behavioral impairment and mitigates Alzheimer-like pathology, In Diet and Nutrition in Dementia and Cognitive Decline, (Martin C and Preedy V ed.)2014
- Author(s)
  Takashi Mori, Terrence Town
- Publisher
  Academic Press, (London), (in press)
- Data Source
  KAKENHI-PROJECT-22500320
[Book] The role of glia in neurotoxicity(Aschner M, Costa LG ed.,)2005
- Author(s)
  Asano T・・・ Mori T et al.
- Publisher
  CRC press L.L.C., (Boca Raton)
- Data Source
  KAKENHI-PROJECT-14571329
[Book] The role of glia in neurotoxicity(Aschner M and Costa LG ed.)2005
- Author(s)
  Asano T., Mori T., et al.
- Publisher
  CRC press L.L.C., (Boca Raton)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Book] The role of glia in neurotoxicity2005
- Author(s)
  Asano T, Mori T et al.
- Publisher
  Aschner M and Costa LG ed., CRC press L.L.C., (Boca Rat on)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Book] Role of astrocytes in medication of stroke : Possible detrimental role of astrocytic activation during the subacute phase of permanent focal cerebral ischemia in the rat. In The role of glia in neurotoxicity, (Aschner M and Costa LG ed.)2005
- Author(s)
  Asano T, Tateishi N, Mori T.
- Publisher
  CRC press L.L.C. (Boca Raton)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Book] Role of astrocytes in medication of stroke : Possible detrimental role of astrocytic activation during the subacute phase of permanent focal cerebral ischemia in the rat (The role of glia in neurotoxicity) (Aschner M and Costa LG ed.)2005
- Author(s)
  Asano T, Mori T
- Publisher
  CRC press L.L.C., (Boca Raton)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Book] Molecular mechanism and epochal therapeutics of ischemic stroke and dementia(Abe K ed.)2003
- Author(s)
  Asano T., Mori T., et al.
- Publisher
  Elesvier Science Publishers B.V., (Amsterdam)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Book] Functional modulation of astrocytes by a novel agent ONO-2506 mitigates delayed infarct expansion with a wide therapeutic time window, inducing prompt neurological recovery through reduction of the extracellular level of glutamate (Molecular mechanism and epochal therapeutics of ischemic stroke and dementia) (Abe K ed.)2003
- Author(s)
  Asano T, Mori T et al.
- Publisher
  Elsevier Science Publishers B.V., (Amsterdam)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Targeting apolipoprotein E and N-terminal amyloid β-protein precursor interaction improves cognition and reduces amyloid pathology in Alzheimer’s mice.2023
- Author(s)
  Darrell Sawmiller, Naoki Koyama, Masakazu Fujiwara, Tatsuya Segawa, Masahiro Maeda, Takashi Mori
- Journal Title
  
  J Biol Chem
  
  Volume: 299, 7 Issue: 7 Pages: 104846-104846
- DOI
  10.1016/j.jbc.2023.104846
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06460
[Journal Article] <scp>CD24</scp> is a surrogate for ‘immune‐cold’ phenotype in aggressive large B‐cell lymphoma2022
- Author(s)
  Higashi Morihiro、Momose Shuji、Takayanagi Natsuko、Tanaka Yuka、Anan Tomoe、Yamashita Takahisa、Kikuchi Jun、Tokuhira Michihide、Kizaki Masahiro、Tamaru Jun‐ichi
- Journal Title
  
  The Journal of Pathology: Clinical Research
  
  Volume: March 2022 Issue: 4 Pages: 340-354
- DOI
  10.1002/cjp2.266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07467, KAKENHI-PROJECT-20K07396, KAKENHI-PROJECT-22K06966
[Journal Article] アルツハイマー病の新規治療法：オクチルガレートとフェルラ酸の併用療法．2017
- Author(s)
  森　隆
- Journal Title
  
  BIO INDUSTRY
  
  Volume: 34 (10) Pages: 23-32
- Data Source
  KAKENHI-PROJECT-26430058
[Journal Article] Cotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice2014
- Author(s)
  Johnathon Alex Grizzell, Alexandre Iarkov, Rosalee Holmes, Takashi Mori, Valentina Echeverria
- Journal Title
  
  Behav Brain Res
  
  Volume: (in press) Pages: 55-65
- DOI
  10.1016/j.bbr.2014.03.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Ferulic acid is a nutraceuticalβ-secretase modulator that improves behavioral impairment and Alzheimer-like pathology in transgenic mice2013
- Author(s)
  Takashi Mori, Naoki Koyama, Marie-Victoire Guillot-Sestier, Jun Tan, Terrence Town
- Journal Title
  
  PLoS ONE
  
  Volume: 8 (2) Issue: 2 Pages: e55774-e55774
- DOI
  10.1371/journal.pone.0055774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Mycoplasma hyorhinis markedly degradesβ-amyloid peptides in vitro and ex vivo : a novel biological approach for treating Alzheimer's disease?2013
- Author(s)
  Ahsan Habib, Juan Deng, Huayan Hou, Qiang Zou, Brian Giunta, Yan-Jiang Wang, Demian Obregon, Darrell Sawmiller, Song Li, Takashi Mori, Jun Tan
- Journal Title
  
  Am J Transl Res
  
  Volume: 5 (6) Pages: 634-642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Octyl gallate markedly promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation2013
- Author(s)
  She-Qing Zhang, Darrell Sawmiller, Song Li, Kavon Rezai-Zadeh, Huayan Hou, Shufeng Zhou, Douglas Shytle, Brian Giunta, Frank Fernandez, Takashi Mori, Jun Tan
- Journal Title
  
  PLoS ONE
  
  Volume: 8 (8) Issue: 8 Pages: e71913-e71913
- DOI
  10.1371/journal.pone.0071913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Mycoplasma hyorhinis markedly degrades β-amyloid peptides in vitro and ex vivo: a novel biological approach for treating Alzheimer’s disease?2013
- Author(s)
  Ahsan Habib, Juan Deng, Huayan Hou, Qiang Zou, Brian Giunta, Yan-Jiang Wang, Demian Obregon, Darrell Sawmiller, Song Li, Takashi Mori, Jun Tan
- Journal Title
  
  Am J Transl Res
  
  Volume: 5 (6) Pages: 634-642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice2012
- Author(s)
  Takashi Mori, et al
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 6912-6927
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Long-term electromagnetic field treatment increases brain neuronal activity: Linkage to cognitive benefit and therapeutic implications for Alzheimer’s disease.2012
- Author(s)
  Takashi Mori
- Journal Title
  
  J Alzheimer's Dis Park
  
  Volume: 1 Issue: 02 Pages: 102-102
- DOI
  10.4172/2161-0460.1000102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] sAPP-αmodulatesβ-secretase activity and amyloid-βgeneration2012
- Author(s)
  Demian Obregon, Huayan Hou, Juan Deng, Brian Giunta, Jun Tian, Donna Darlington, MD Shahaduzzaman, Yuyuan Zhu, Takashi Mori, Mark P. Mattson, Jun Tan
- Journal Title
  
  Nat Commun
  
  Volume: 3 Issue: 1 Pages: 777-777
- DOI
  10.1038/ncomms1781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Autoreactive-Aβantibodies promote APPβ-secretase processing2012
- Author(s)
  Juan Deng, Huayan Hou, Brian Giunta, Takashi Mori, Yan-Jiang Wang, Frank Fernandez, Sascha Weggen, Wataru Araki, Demian Obregon, Jun Tan
- Journal Title
  
  J Neurochem
  
  Volume: 120 (5) Issue: 5 Pages: 732-740
- DOI
  10.1111/j.1471-4159.2011.07629.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Tannic acid is a naturalβ-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice2012
- Author(s)
  Takashi Mori, Kavon Rezai-Zadeh, Naoki Koyama, Gary W. Arendash, Haruyasu Yamaguchi, Nobuto Kakuda, Yuko Horikoshi-Sakuraba, Jun Tan, Terrence Town
- Journal Title
  
  J Biol Chem
  
  Volume: 287 (9) Issue: 9 Pages: 6912-6927
- DOI
  10.1074/jbc.m111.294025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] CD45 deficiency drives Aβoligomers and neuronal loss in Alzheimer's disease mice2011
- Author(s)
  Yuyan Zhu, Huayan Hou, Brian Giunta, Amanda Ruscin, Carmelina Gemma, JingJi Jin, Natasa Dragicevic, Patrick Bradshaw, Suhail Rasool, Charles Glabe, Paula Bickford, Takashi Mori, Demian F. Obregon, Terrence Town, Jun Tan
- Journal Title
  
  J Neurosci
  
  Volume: 31 (4) Issue: 4 Pages: 1355-1365
- DOI
  10.1523/jneurosci.3268-10.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology2011
- Author(s)
  Yuyan Zhu, Demian F. Obregon, Huayan Hou, Brian Giunta, Jared Erhart, Frank Fernandez, Takashi Mori, William Nikolic, Yangbing Zhao, Dave Morgan, Terrence Town, Jun Tan
- Journal Title
  
  J Cell Mol Med
  
  Volume: 15 (2) Issue: 2 Pages: 327-338
- DOI
  10.1111/j.1582-4934.2009.00962.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Cotinine reduces amyloid-βaggregation and improves memory in Alzheimer's mice2011
- Author(s)
  Valentina Echeverria, Ross Zeitlin, Sarah Burgess, Sagar Patel, Arghya Barman, Garima Thakur, Magorzota B. Mamcarz, Li Wang, David B. Sattelle, Daniel A Kirschner, Takashi Mori, Roger M. Leblanc, Rajeev Prabhakar, Gary W. Arendash
- Journal Title
  
  J Alzheimer's Dis
  
  Volume: 24 (4) Issue: 4 Pages: 817-835
- DOI
  10.3233/jad-2011-102136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Granulocyte-colony stimulating factor (G-CSF) enhances recovery in mouse model of Parkinson's disease2011
- Author(s)
  Shijie Song, Vasyl Sava, Amanda Rowe, Kunyu Lia, Chuanhai Cao, Takashi Mori, Juan Sanchez-Ramos
- Journal Title
  
  Neurosci Lett
  
  Volume: 487 (2) Issue: 2 Pages: 153-157
- DOI
  10.1016/j.neulet.2010.10.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Targeting S100B in cerebral ischemia and in Alzheimer's disease2010
- Author(s)
  Takashi Mori, Takao Asano, Terrence Town
- Journal Title
  
  Cardiovasc Psychiatry Neurol
  
  Volume: Vol. 2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease2010
- Author(s)
  Mori T, Koyama N, Arendash GW, Horikoshi-Sakuraba Y, Tan J, Town T
- Journal Title
  
  Glia. 58(3)
  
  Pages: 300-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300122
[Journal Article] Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease.2010
- Author(s)
  Mori T, Koyama N, Arendash GW, Horikoshi-Sakuraba Y, Tan J, Town T
- Journal Title
  
  Glia. 58(3)
  
  Pages: 300-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300122
[Journal Article] Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease.2010
- Author(s)
  Takashi Mori
- Journal Title
  
  Glia
  
  Volume: 58 Pages: 300-314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Rapamycin promotes beta-amyloid production via ADAM-10 inhibition.2010
- Author(s)
  Zhang S, Salemi J, Hou H, Zhu Y, Mori T, Giunta B, Obregon D, Tan J
- Journal Title
  
  Biochem Biophys Res Commun. 398(3)
  
  Pages: 337-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300122
[Journal Article] Targeting S100B in Cerebral Ischemia and in Alzheimer's Disease.2010
- Author(s)
  Mori T, Asano T, Town T
- Journal Title
  
  Cardiovasc Psychiatry Neurol.
  
  Pages: 687067-687067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300122
[Journal Article] Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease2010
- Author(s)
  Takashi Mori
- Journal Title
  
  Glia 58
  
  Pages: 300-314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Rapamycin promotesβ-amyloid production via ADAM-10 inhibition2010
- Author(s)
  Shequing Zhang, Jon Salemi, Huayan Hou, Yuyan Zhu, Takashi Mori, Brian Giunta, Demian F. Obregon, Jun Tan
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 398 (3) Issue: 3 Pages: 337-341
- DOI
  10.1016/j.bbrc.2010.06.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Terrence Town. Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease.2010
- Author(s)
  Takashi Mori, Naoki Koyama, Gary W. Arendash, Yuko Horikoshi-Sakuraba, Jun Tan
- Journal Title
  
  Glia 58(3)
  
  Pages: 300-314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] GM-CSF upregulated in rheumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice2010
- Author(s)
  Timothy D. Boyd, Steven P. Bennett, Takashi Mori, Nickolas Governatori, Melissa J. Runfeldt, Michelle Norden, Jaya Padmanabhan, Peter Neame, Inge Wefes, Juan Sanchez-Ramos, Gary W. Arendash, Huntington Potter
- Journal Title
  
  J Alzheimer's Dis
  
  Volume: 21 (2) Issue: 2 Pages: 507-518
- DOI
  10.3233/jad-2010-091471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500320
[Journal Article] Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease.2010
- Author(s)
  Mori T, 他5名
- Journal Title
  
  Glia 58
  
  Pages: 300-314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300122
[Journal Article] Huntington Potter. Caffeine reverses cognitive impairment and decreases brain amyloid-βlevels in aged Alzheimer's disease mice.2009
- Author(s)
  Gary W. Arendash, Takashi Mori, Chuanhai Cao, Malgorzata B. Mamcarz, Melissa J. Runfeldt, Alexander Dickson, Kavon Rezai-Zadeh, Jun Tan, Bruce A. Citron, Xiaoyang Lin, Valentina Echeverria
- Journal Title
  
  J Alzheimer's Dis 17(3)
  
  Pages: 661-680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Huntington Potter. Caffeine suppresses amyloid-βlevels in plasma and brain of Alzheimer's disease transgenic mice.2009
- Author(s)
  Chuanhai Cao, John R. Cirrito, Xiaoyang Lin, Lilly Wang, Deborah K. Verges, Alexander Dickson, Malgorzata B. Mamcarz, Chi Zhang, Takashi Mori, Gary W. Arendash, David M. Holtzman
- Journal Title
  
  J Alzheimer's Dis 17(3)
  
  Pages: 681-697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Caffeine reverses cognitive impairment and decreases brain amyloid-βlevels in aged Alzheimer's disease mice.2009
- Author(s)
  Arendash GW, Mori T, 他11名
- Journal Title
  
  J Alzheimer's Dis 17
  
  Pages: 3661-3680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300122
[Journal Article] Blocking TGF-β/SMAD 2/3 innate immune signaling mitigates Alzheimer-like pathology2008
- Author(s)
  Terrence Town, Yasmina Laouar, Christopher Pittenger, Takashi Mori, Christine A. Szekely, Jun Tan, Ronald S. Duman, Richard A. Flavell
- Journal Title
  
  Nat Med 14 (6)
  
  Pages: 681-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Richard A. Flavell. Blocking TGF-β/SMAD 2/3 innate immune signaling mitigates Alzheimer-like pathology.2008
- Author(s)
  Terrence Town, Yasmina Laouar, Christopher Pittenger, Takashi Mori, Christine A. Szekely, Jun Tan, Ronald S. Duman
- Journal Title
  
  Nat Med 14(6)
  
  Pages: 681-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular β-amyloid deposits and suppress CD40-CD40L interaction2008
- Author(s)
  William V. Nikolic, Huayan Hou, Terrence Town, Yuyan Zhu, Brian Giunta, Cyndy D. Sanberg, Jin Zeng, Deyan Luo, Jared Ehrhart, Takashi Mori, Paul R. Sanberg, Jun Tan
- Journal Title
  
  Stem Cells Dev 17 (3)
  
  Pages: 423-440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Terrence Town, Jun Tan. CD40L disruption enhances Aβvaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.2008
- Author(s)
  Demian F. Obregon, Huayan Hou, Yun Bai, William Nikolic, Takashi Mori, Deyan Luo, Jin Zeng, Jared Ehrhart, Frank Fernandez, Dave Morgan, Brian Giuntan
- Journal Title
  
  Neurobiol Dis 29(2)
  
  Pages: 336-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemia.2008
- Author(s)
  Mori T, Tan J, Arendash GW, Koyama N, Nojima Y, Town T
- Journal Title
  
  Stroke 39(7)
  
  Pages: 2114-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300122
[Journal Article] CD40L disruption enhances Aβ vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation.2008
- Author(s)
  Demian F. Obregon, Takashi Mori, et al.
- Journal Title
  
  Neurobiol Dis 29(2)
  
  Pages: 336-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular β-amyloid deposits and suppress CD40-CD40L interaction.2008
- Author(s)
  William V. Nikolic, Takashi Mori, et al.
- Journal Title
  
  Stem Cells Dev 17(3)
  
  Pages: 423-440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] CD40L disruption enhances Aβ vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation2008
- Author(s)
  Demian F. Obregon, Huayan Hou, Yun Bai, William Nikolic, Takashi Mori, Deyan Luo, Jin Zeng, Jared Ehrhart, Frank Fernandez, Dave Morgan, Brian Giuntan, Terrence Town, Jun Tan.
- Journal Title
  
  Neurobiol Dis 29(2)
  
  Pages: 336-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Blocking TGF-β/SMAD 2/3 innate immune signaling mitigates Alzheimer-like pathology.2008
- Author(s)
  Terrence Town, Takashi Mori, et al.
- Journal Title
  
  Nat Med 14(6)
  
  Pages: 681-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Jun Tan. Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular β-amyloid deposits and suppress CD40-CD40L interaction.2008
- Author(s)
  William V. Nikolic, Huayan Hou, Terrence Town, Yuyan Zhu, Brian Giunta, Cyndy D. Sanberg, Jin Zeng, Deyan Luo, Jared Ehrhart, Takashi Mori, Paul R. Sanberg
- Journal Title
  
  Stem Cells Dev 17(3)
  
  Pages: 423-440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Enhanced cognitive activity--over and above socialor physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity.2007
- Author(s)
  Cracchiolo JR, Mori T, Nazian SJ, Tan J, Potter H, Arendash GW
- Journal Title
  
  Neurobiol Learn Mem. 88(3)
  
  Pages: 277-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300122
[Journal Article] Transcutaneous β-amyloid peptide immunization reduces cerebral β-amyloid deppsits wihout T cell infilraion and microhemorrhage.2007
- Author(s)
  W.V. Nikolic,.. T. Mori, et. al.
- Journal Title
  
  Proc Natl Acad Sci U.S.A. 104(7)
  
  Pages: 2507-2512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Enhanced cognitive activity-over and above social or physical activity-is required to protect Alzheimer's mice against cognitive impairment,reduce Aβ deposition,and increase synaptic immunoreactivity.2007
- Author(s)
  J.R. Cracchiolo, T. Mori, et. al.
- Journal Title
  
  Neurobiol Learn Mem 88(3)
  
  Pages: 277-294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage.2007
- Author(s)
  Nikolic WV, Bai Y, Obregon D, Hou H, Mori T, Zeng J, Ehrhart J, Shytle RD, Giunta B, Morgan D, Town T, Tan J
- Journal Title
  
  Proc Natl Acad Sci U S A. 104(7)
  
  Pages: 2507-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300122
[Journal Article] Enhanced cognitive activity-over and above social or physical activity- is required to protect Alzheimer's mice against cognitive impairment, reduce Aβdeposition, and increase synaptic immunoreactivity.2007
- Author(s)
  Jennifer R. Cracchiolo, Takashi Mori, Stanley J. Nazian, Jun Tan, Huntington Potter, Gary W. Arendash.
- Journal Title
  
  Neurobiol Learn Mem 88(3)
  
  Pages: 277-294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Transcutaneous β-amyloid peptide immunization reduces cerebral β-amyloid deposits without T cell infiltration and microhemorrhage.2007
- Author(s)
  William V. Nikolic, Yun Bai, Demian F. Obregon, Huayan Hou, Takashi Mori, Jin Zeng, Jared Ehrhart, R. Douglas Shytle, Brian Giunta, Dave Morgan, Terrence Town, Jun Tan.
- Journal Title
  
  Proc Natl Acad Sci U.S.A. 104(7)
  
  Pages: 2507-2512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Douglas Shytle, Brian Giunta, Dave Morgan, Terrence Town, Jun Tan. Transcutaneous β-amyloid peptide immunization reduces cerebral β-amyloid deposits without T cell infiltration and microhemorrhage2007
- Author(s)
  William V. Nikolic, Yun Bai, Demian F. Obregon, Huayan Hou, Takashi Mori, Jin Zeng, Jared Ehrhart, R.
- Journal Title
  
  Proc Natl Acad Sci U. S. A. 104 (7)
  
  Pages: 2507-2512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Enhanced cognitive activity-over and above social or physical activity-is required to protect Alzheimer-s mice against cognitive impairment, reduce Aβ deposition, and increase synaptic immunoreactivity2007
- Author(s)
  Jennifer R. Cracchiolo, Takashi Mori, Stanley J. Nazian, Jun Tan, Huntington Potter, Gary W. Arendash
- Journal Title
  
  Neurobiol Learn Mem 88 (3)
  
  Pages: 277-294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Terrence Town, Jun Tan, Nobumichi Yada, Yuko Horikoshi, Junki Yamamoto, Taiji Shimoda, Yoshihisa Kamanaka, Narito Tateishi, Takao Asano. Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice.2006
- Author(s)
  Takashi Mori
- Journal Title
  
  J Pharmacol Exp Ther 318 (2)
  
  Pages: 571-578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice.2006
- Author(s)
  Takashi Mori
- Journal Title
  
  J Pharmacol Exp Ther 318(2)
  
  Pages: 571-578
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice.2006
- Author(s)
  Takashi Mori, Terrence Town, Jun Tan, Nobumichi Yada, Yuko Horikoshi, Junki Yamamoto, Taiji Shimoda, Yoshihisa Kamanaka, Narito Tateishi, Takao Asano
- Journal Title
  
  J Pharmacol Exp Ther 318(2)
  
  Pages: 571-578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Arundic acid (ONO-2506) ameliorates ischemic brain damage by preventing astrocytic overproduction of S100B.2005
- Author(s)
  Asano T, Mori T et al.
- Journal Title
  
  Curr Drug Targets-CNS & Neurologic Disord 4(2)
  
  Pages: 127-142
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in mice.2005
- Author(s)
  Mori T
- Journal Title
  
  J Cereb Blood Flow and Metab 25・6
  
  Pages: 748-762
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16300110
[Journal Article] Arundic acid (ONO-2506) ameliorates ischemic brain damage by preventing astrocytic overproduction of S100B2005
- Author(s)
  Asano T, Mori T. et al.
- Journal Title
  
  Curr Drug Targets- CNS & Neurologic Disord (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Apolipoprotein E isoform and ischemic brain injury.2005
- Author(s)
  Mori T, Asano T.
- Journal Title
  
  Cerebral Blood Flow and Metabolism 17(1)
  
  Pages: 61-67
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in mice.2005
- Author(s)
  Mori T, Town T, Tan J, Tateishi N, Asano T.
- Journal Title
  
  J Cereb Blood Flow and Metab 25(6)
  
  Pages: 748-762
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in mice.2005
- Author(s)
  Mori T et al.
- Journal Title
  
  Journal of Cerebral Blood Flow and Metabolism 25(6)
  
  Pages: 748-762
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in mice.2005
- Author(s)
  Mori T, et al.
- Journal Title
  
  J Cereb Blood Flow Metab 25・6
  
  Pages: 748-762
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16300110
[Journal Article] Apolipoprotein E isoform and ischemic brain injury.2005
- Author(s)
  Mori T, Asano T
- Journal Title
  
  Cerebral Blood Flow and Metabolism 17(1)
  
  Pages: 61-67
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Apolipoprotein E isoform and ischemic brain injury.2005
- Author(s)
  Mori T, Asano T
- Journal Title
  
  Cerebral Blood Flow and Metabolism 17 (1)
  
  Pages: 61-67
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 is oform after permanent focal ischemia in apolipoprotein E knock-in mice.2005
- Author(s)
  Mori T et al.
- Journal Title
  
  Journal of Cerebral Blood Flow and Metabolism 25 (6)
  
  Pages: 748-762
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Arundic acid (ONO-2506) ameliorates ischemic brain damage by preventing astrocytic overproduction of S100B.2005
- Author(s)
  Asano T, Mori T, Shimoda T, Shinagawa R, Satoh S, Yada N, Katsumata S, Matsuda S, Kagamiishi Y, Tateishi N.
- Journal Title
  
  Curr Drug Targets- CNS & Neurologic Disord 4(2)
  
  Pages: 127-142
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Arundic acid (ONO-2506) ameliorates ischemic brain damage by preventing astrocytic overproduction of S100B.2005
- Author(s)
  Asano T, Mori T... et al.
- Journal Title
  
  Current Drug Targets-CNS & Neurologic Disorder 4(2)
  
  Pages: 127-142
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Arundic acid (ONO-2506) ameliorates ischemic brain damage by preventing astrocytic overproduction of S100B.2005
- Author(s)
  Asano T, Mori T, et al.
- Journal Title
  
  Current Drug Targets-CNS & Neurologic Disorder (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice.2004
- Author(s)
  Mori T, Town T, Kobayashi M, Tan J, Fujita SC, Asano T.
- Journal Title
  
  J Cereb Blood Flow and Metab 24(6)
  
  Pages: 646-656
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Attenuation of a delayed increase in the extracellular glutamate level in the peri-infarct area following focal cerebral ischemia by a novel agent ONO-2506.2004
- Author(s)
  Mori T., Asano T
- Journal Title
  
  Neurochem Int 45(2-3)
  
  Pages: 381-387
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice.2004
- Author(s)
  Mori T
- Journal Title
  
  J Cereb Blood Flow and Metab 24・6
  
  Pages: 646-656
- Data Source
  KAKENHI-PROJECT-16300110
[Journal Article] Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knocl-in mice.2004
- Author(s)
  Mori T et al.
- Journal Title
  
  Journal of Cerebral Blood Flow and Metabolism 24(6)
  
  Pages: 646-656
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice.2004
- Author(s)
  Mori T et al.
- Journal Title
  
  J Cereb Blood Flow and Metab 24・6
  
  Pages: 646-656
- Data Source
  KAKENHI-PROJECT-16015101
[Journal Article] Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice.2004
- Author(s)
  Mori T et al.
- Journal Title
  
  Journal of Cerebral Blood Flow and Metabolism 24 (6)
  
  Pages: 646-656
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Attenuation of a delayed increase in the extracellular glutamate level in the peri-infarct area following focal cerebral ischemia by a novel agent ONO-25062004
- Author(s)
  Mori T, Asano T
- Journal Title
  
  Neurochem Int 45(2-3)
  
  Pages: 381-387
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Attenuation of a delayed increase in the extracellular glutamate level in the peri-infarct area following focal cerebral ischemia by a novel agent ONO-2506.2004
- Author(s)
  Mori T
- Journal Title
  
  Neurochem Int 45・2-3
  
  Pages: 381-387
- Data Source
  KAKENHI-PROJECT-16300110
[Journal Article] Attenuation of a delayed increase in the extracellular glutamate level in the peri-infarct area following focal cerebral ischemia by a novel agent ONO-2506.2004
- Author(s)
  Mori T et al.
- Journal Title
  
  Neurochem Int 45・2-3
  
  Pages: 381-387
- Data Source
  KAKENHI-PROJECT-16015101
[Journal Article] Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in mice.2003
- Author(s)
  Mori T, Kobayashi M, Town T, Fujita SC, Asano T.
- Journal Title
  
  J Neuropathol Exp Neurol 62(3)
  
  Pages: 280-291
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in mice.2003
- Author(s)
  Mori T......Asano T
- Journal Title
  
  Journal of Neuropathology and Experimental Neurology 62
  
  Pages: 280-291
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Astrocytic activation and delayed infarct expansion following permanent focal ischemia in rats. Part II : Suppression of astrocytic activation by a novel agent (R)-(-)-2 propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurological deficits.2002
- Author(s)
  Tateishi N, Mori T, Morikawa E, Asano T
- Journal Title
  
  J Cereb Blood Flow and Metab 22(6)
  
  Pages: 723-734
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Astrocytic activation and delayed infarct expansion following permanent focal ischemia in rats. Part II : Suppression of astrocytic activation by a novel agent (R)-(-)-2 propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurological deficits2002
- Author(s)
  Tateishi N, Mori T, Morikawa E, Asano T
- Journal Title
  
  J Cereb Blood Flow and Metab 22(6)
  
  Pages: 723-734
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Astrocytic activation and delayed infarct expansion following permanent focal ischemia in rats. Part I : Enhanced astrocytic synthesis of S- 100β in the periinfarct area precedes the occurrence of delayed infarct expansion2002
- Author(s)
  Matsui T, Mori T, Morikawa E, Asano T
- Journal Title
  
  J Cereb Blood Flow and Metab 22(6)
  
  Pages: 711-722
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Astrocytic activation and delayed infarct expansion fdlowing permanent focal ischemia in rats. Part I : Enhanced astrocytic synthesis of S-100β in the periinfarct area precedes the occurrence of delayed infarct expansion.2002
- Author(s)
  Matsui T., Mori T., Morikawa E., Asano T
- Journal Title
  
  J Cereb Blood Flow and Metab 22(6)
  
  Pages: 711-722
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Presentation] アポリポ蛋白E-アミロイド前駆体蛋白結合を標的としたアルツハイマー病の新規治療法．2023
- Author(s)
  森　隆，Darrell Sawmiller，小山直基，瀬川辰也，前田雅弘，藤原正和
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K06460
[Presentation] アポリポ蛋白E-アミロイド前駆体蛋白結合を標的としたアルツハイマー病の治療法の開発．2023
- Author(s)
  藤原正和，小山直基，森　隆
- Organizer
  第70回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-22K06460
[Presentation] アポリポ蛋白E-アミロイド前駆体蛋白結合阻害剤（6KApoEp）によるアルツハイマー様病態の改善効果2022
- Author(s)
  藤原正和，小山直基、森　隆
- Organizer
  第69回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-22K06460
[Presentation] 新規アルツハイマー病治療薬：アポリポ蛋白E由来ペプチド2022
- Author(s)
  小山直基、藤原正和，森　隆
- Organizer
  第69回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-22K06460
[Presentation] エピガロカテキン3-ガレート・フェルラ酸の併用投与によるアルツハイマー様病態改善の加算効果．2017
- Author(s)
  小山直基，森　隆
- Organizer
  第64回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-26430058
[Presentation] Combination therapy with (-)-epigallocatechin-3-gallate and ferulic acid effectively modifies Alzheimer-like pathology.2017
- Author(s)
  Takashi Mori, Naoki Koyama, Jun Tan, Tatsuya Segawa, Masanori Maeda, Terrence Town
- Organizer
  Neuroscience 17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430058
[Presentation] セクレターゼ標的薬剤の併用投与による行動学的障害及び脳アミロイド症の病態改善の相乗効果．2016
- Author(s)
  小山直基，森　隆
- Organizer
  第63回日本実験動物学会総会
- Place of Presentation
  ミューザ川崎シンフォニーホール（神奈川県・川崎市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26430058
[Presentation] セクレターゼ標的薬剤の併用投与による行動学的障害及び脳アミロイド症の病態改善の相乗効果2016
- Author(s)
  小山直基、森　　隆
- Organizer
  第63回日本実験動物学会総会
- Place of Presentation
  ミューザ川崎シンフォニーホール（神奈川県・川崎市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26430058
[Presentation] Combined secretase modulation therapy provides cognitive benefit and ameliorates cerebral amyloid pathology in transgenic mice.2015
- Author(s)
  Takashi Mori, Naoki Koyama, Jun Tan, Terrence Town
- Organizer
  Neuroscience 15
- Place of Presentation
  Chicago, IL, USA
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430058
[Presentation] フェルラ酸・オクチルガレート併用投与による行動学的障害の改善効果：アルツハイマーモデルマウスでの検討．2015
- Author(s)
  小山直基，森　隆
- Organizer
  第62回日本実験動物学会総会
- Place of Presentation
  京都テルサ（京都府・京都市）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26430058
[Presentation] セクレターゼ標的薬剤（フェルラ酸・オクチルガレート）の併用投与によるアルツハイマー様病態の改善効果．2015
- Author(s)
  森　隆
- Organizer
  第27回日本脳循環代謝学会総会
- Place of Presentation
  富山国際会議場（富山県・富山市）
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-26430058
[Presentation] Octyl gallate promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation.2013
- Author(s)
  Darrell Sawmiller, She-Qing Zhang, Kavon Rezai-Zadeh, Huayan Hou, Jared Ehrhart, Douglas Shytle, Shufeng Zhou, Brian Giunta, Takashi Mori, Jun Tan
- Organizer
  Neuroscience 13
- Place of Presentation
  San Diego, U.S.A.
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] Octyl gallate promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation2013
- Author(s)
  Darrell Sawmiller, She-Qing Zhang, Kavon Rezai-Zadeh, Huayan Hou, Jared Ehrhart, Douglas Shytle, Shufeng Zhou, Brian Giunta, Takashi Mori, Jun Tan
- Organizer
  Neuroscience 13
- Place of Presentation
  San Diego, U.S.A
- Year and Date
  2013-11-12
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] Methylene blue reverses behavioral impairment and ameliorates cerebral amyloidosis in PSAPP mice.2013
- Author(s)
  Takashi Mori, Naoki Koyama, Tatsuya Segawa, Noriaki Kinoshita, Huayan Hou, Jun Tan, Terrence Town
- Organizer
  Neuroscience 13
- Place of Presentation
  San Diego, U.S.A.
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] Methylene blue reverses behavioral impairment and ameliorates cerebral amyloidosis in PSAPP mice2013
- Author(s)
  Takashi Mori, Naoki Koyama, Tatsuya Segawa, Noriaki Kinoshita, Huayan Hou, Jun Tan, Terrence Town
- Organizer
  Neuroscience 13
- Place of Presentation
  San Diego, U.S.A
- Year and Date
  2013-11-12
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] Soluble amyloid precursor protein-αmodulatesβ-secretase activity and amyloid-βgeneration2013
- Author(s)
  Demian Obregon, Huayan Hou, Juan Deng, Brian Giunta, Jun Tian, Donna Darlington, Md Shahaduzzaman, Takashi Mori, Mark P. Mattson, Jun Tan
- Organizer
  Neuroscience 13
- Place of Presentation
  San Diego, U.S.A
- Year and Date
  2013-11-09
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation.2013
- Author(s)
  Demian Obregon, Huayan Hou, Juan Deng, Brian Giunta, Jun Tian, Donna Darlington, Md Shahaduzzaman, Takashi Mori, Mark P. Mattson, Jun Tan
- Organizer
  Neuroscience 13
- Place of Presentation
  San Diego, U.S.A.
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] Cotinine prevented working memory loss in a mouse model of posttraumatic stress-induced cognitive impairment2012
- Author(s)
  Jonathon Alex Grizzell, Alexandre Iarkov, Rosalee Holmes, Takashi Mori, Valentina Echeverria
- Organizer
  Neuroscience 12
- Place of Presentation
  New Orleans, U.S.A
- Year and Date
  2012-10-14
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] Naturally-occurringβ-secretase inhibitors mitigate behavioral impairment, cerebral amyloidosis and neuroinflammation in Alzheimer transgenic mice2012
- Author(s)
  Terrence Town, Marie-Victoire Guillot-Sestier, Kavon Rezai-Zadeh, Jun Tan, Takashi Mori
- Organizer
  Neuroscience 12
- Place of Presentation
  New Orleans, U.S.A
- Year and Date
  2012-10-13
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] Posttreatment with cotinine improved working memory, reduced amyloid-βplaques and decreased depressive-like behavior in the Tg6799 mice2012
- Author(s)
  Valentina Echeverria, Ross Zeitlin, Sagar Patel, Rosalynn Solomon, Cuc Hong Tran, Jonathon Alex Grizzell, Alexandre Iarkov, Takashi Mori
- Organizer
  Neuroscience 12
- Place of Presentation
  New Orleans, U.S.A
- Year and Date
  2012-10-16
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] Autoreactive-Aβantibodies promote APPβ-secretase processing2012
- Author(s)
  Juan Deng, Huayan Hou, Brian Giunta, Takashi Mori, Yan-Jiang Wang, Frank Fernandez, Sascha Weggen, Wataru Araki, Demian Obregon, Jun Tan
- Organizer
  Neuroscience 12
- Place of Presentation
  New Orleans, U.S.A
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] The phenolic compound ferulic acid ameliorates cognitive impairment and amyloidosis in Alzheimer mice2011
- Author(s)
  Takashi Mori, et al
- Organizer
  41^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington D.C., U.S.A.
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] The phenolic compound ferulic acid ameliorates cognitive impairment and amyloidosis in Alzheimer mice2011
- Author(s)
  Takashi Mori, Kavon Rezai-Zadeh, Naoki Koyama, Yuko Horikoshi-Sakuraba, Jun Tan, Terrence Town
- Organizer
  Neuroscience 11
- Place of Presentation
  Washington D.C., U.S.A
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] Neuroinflammation as an early event and prime mover in Alzheimer's disease. (Nanosymposium)2011
- Author(s)
  Terrence Town, Takashi Mori, Robert M. Cohen, Jun Tan, Kavon Rezai-Zadeh
- Organizer
  Neuroscience 11
- Place of Presentation
  Washington D.C., U.S.A
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] Neuroinflammation as an early event and prime mover in Alzheimer's pathobiology2011
- Author(s)
  Terrence Town, Takashi Mori, Robert M. Cohen, Jun Tan, Kavon Rezai-Zadeh
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease
- Place of Presentation
  Paris, France
- Year and Date
  2011-07-18
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] The plant-derived polyphenol tannic acid mitigates Alzheimer's disease-like pathology2010
- Author(s)
  Takashi Mori, Naoki Koyama, Kavon Rezai-Zadeh, Nobuto Kakuda, Haruyasu Yamaguchi, Gary W. Arendash, Jun Tan, Terrence Town
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease
- Place of Presentation
  Honolulu, U.S.A
- Year and Date
  2010-07-13
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] Cotinine : A dual action drug with multiple benefits against Alzheimer's disease2010
- Author(s)
  Valentina Echeverria, Sarah Burgess, Ross Zeitlin, Arghya Barman, Garima Thakur, Hideyo Inouye, Edmundo Feris, Steven Buckingham, Daniel Kirschner, Takashi Mori, Roger Leblanc, Rajeev Prabhakar, David Sattelle, Gary W. Arendash
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease
- Place of Presentation
  Honolulu, U.S.A
- Year and Date
  2010-07-13
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] The plant-derived polyphenol tannic acid mitigates Alzheimer's disease-like pathology.2010
- Author(s)
  Takashi Mori
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease
- Place of Presentation
  Honolulu, U.S.A.
- Year and Date
  2010-07-13
- Data Source
  KAKENHI-PROJECT-22500320
[Presentation] ヒトS100B蛋白の過剰発現はアルツハイマー様病態(脳アミロイド症・グリオーシス)を増悪させる.2009
- Author(s)
  小山直基, 堀越(櫻庭)優子, 森隆
- Organizer
  第147回日本獣医学会学術集会
- Place of Presentation
  (栃木, 日本)
- Year and Date
  2009-04-03
- Data Source
  KAKENHI-PROJECT-18500279
[Presentation] Overexpression of S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease2008
- Author(s)
  Takashi Mori, Jun Tan, Yoshiko Nojima, Naoki Koyama, Yuko Horikoshi-Sakuraba, Masamitsu Hoshikawa, Rika Shinagawa, Yoshihisa Kamanaka, Gary W. Arendash, Terrence Town
- Organizer
  38^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington D.C., U.S.A.
- Data Source
  KAKENHI-PROJECT-18500279
[Presentation] Terrence Town. Overexpression of S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease.2008
- Author(s)
  Takashi Mori, Jun Tan, Yoshiko Nojima, Naoki Koyama, Yuko Horikoshi-Sakuraba, Masamitsu Hoshikawa, Rika Shinagawa, Yoshihisa Kamanaka, Gary W. Arendash
- Organizer
  38th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington D.C., U.S.A.
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-18500279
[Presentation] Overexpression of S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease.2008
- Author(s)
  Takashi Mori, et al.
- Organizer
  38^<th> Annual Meeting of Society for Neuroscience
- Place of Presentation
  Washington D. C., U.S.A.
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-18500279
[Presentation] A new therapeutic agent for Alzheimer disease: Arundic acid (ONO-2506) attenuates cerebral amyloidosis and gliosis in Alzheimer transgenic mice.2007
- Author(s)
  Takashi Mori, Terrence Town, Jun Tan, Nobumichi Yada, Junki Yamamoto, Masamitsu Hoshikawa, Rika Shinagawa, Yoshihisa Kamanaka, Naoki Koyama, Takao Asano.
- Organizer
  International Psychogeriatric Association (IPA) 2007 Osaka Silver Congress
- Place of Presentation
  Osaka, Japan
- Year and Date
  2007-10-17
- Data Source
  KAKENHI-PROJECT-18500279
[Presentation] A new therapeutic agent for Alzheimer disease:Arundic acid (ONO-2506) attenuates cerebral amyloidosis and gliosis in Alzheimerl transgenic mice.2007
- Author(s)
  T. Mori, et. al.
- Organizer
  International Psychogeriatric Association(IPA) 2007 0saka Silver Congress
- Place of Presentation
  (Osaka,Japan)
- Year and Date
  2007-10-15
- Data Source
  KAKENHI-PROJECT-18500279
[Presentation] A new therapeutic agent for Alzheimer disease : Arundic acid (ONO-2506) attenuates cerebral amyloidosis and gliosis in Alzheimer transgenic mice2007
- Author(s)
  Takashi Mori, Terrence Town, Jun Tan, Nobumichi Yada, Junki Yamamoto, Masamitsu Hoshikawa, Rika Shinagawa, Yoshihisa Kamanaka, Naoki Koyama, Takao Asano
- Organizer
  International Psychogeriatric Association (IPA) 2007 Osaka Silver Congress
- Place of Presentation
  Osaka, Japan
- Data Source
  KAKENHI-PROJECT-18500279

1. YAMAGUCHI Haruyasu (00158114)

# of Collaborated Projects: 7 results

# of Collaborated Products: 2 results
2. SASAKI Atsushi (80225862)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. ASANO Takao (70090496)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
4. 佐藤久美子 (80008268)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. MORIKAWA Eiharu (90251256)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. Momose Shuji (70360344)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. IWASHITA Yoshiko (50111498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. AOSH Sadamitsu (70167914)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OHSAWA Ikuroh (30343586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 山崎恒夫 (80200658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 横尾友隆 (80400688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 藤原正和 (20312069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. KOYAMA NAOKI

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
14. OKADA SACHIKO

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. RYUMAE SHINYA

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MAEDA MASAHIRO

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. MARUYAMA NOBUHIRO

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TAN JUN

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. TOWN TERRENCE

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. 東守洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 田丸淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mori Takashi 森 隆

森 隆 モリ タカシ

MORI Takashi 森 隆

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Targeting apolipoprotein E for Alzheimer's disease therapy.Principal Investigator

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Alzheimer's disease: Exploration of combination therapy with food-derived amyloid-beta peptide modulators and environmental therapy.Principal Investigator

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Development of a new therapeutic strategy for Alzheimer's disease: Exploration of amyloid-beta inhibitors derived from foods and environment enrichment therapy.Principal Investigator

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Possible role of glial cells in the progression of Alzheimer's disease pathologyPrincipal Investigator

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Comparison of apolipoprotein E isoform-specific effects after experimental cerebral ischemia.Principal Investigator

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脳血管攣縮に於けるsuperoxide anionの関与と細胞障害機序の解明Principal Investigator

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Mori Takashi 森隆

森隆モリタカシ

MORI Takashi 森隆