Kimata Yoko 木股洋子

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… Alternative Names

有賀洋子

ARIGA YOKO 有賀洋子(木股洋子)

有賀洋子アリガヨウコ

木股洋子

有賀洋子(木股洋子) アリガヨウコ

ARIGA Yoko 有賀洋子

KIMATA Yoko 木股洋子

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Researcher Number	60255429
Other IDs
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Affiliation (Current)	2025: 山口大学, 大学院創成科学研究科 , 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 山口大学, 大学院創成科学研究科, 教授 2017 – 2022: 山口大学, 大学院創成科学研究科, 准教授 2011 – 2014: 大阪大学, たんぱく質研究所, 助教 1998 – 2003: 大阪大学, たんぱく質研究所, 助手 1998 – 1999: 大阪大学, 蛋白質研究所, 助手 1997: 慶應義塾大学, 医学部, 助手 1993 – 1994: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Functional biochemistry / Functional biochemistry / Structural biochemistry Except Principal Investigator Biological Sciences / 植物生理 / Biophysics / Basic Section 43040:Biophysics-related / Basic Section 37010:Bio-related chemistry / Basic Section 43020:Structural biochemistry-related / Bio-related chemistry
Keywords	Principal Investigator フェレドキシン / 薬剤耐性メカニズム / マラリア原虫 / アルテミシニン / 薬剤耐性 / 立体構造解析 / 電子分配 / 葉緑体 / 蛋白質間相互作用 / 光合成電子伝達 … More / 光合成 / 生体エネルギー変換 / プロトン輸送経路 / シトクロムp450 / 部位特異的同位体ラベル法 / シトクロム P450cam / 酵素触媒機構 / タンパク質工学 / 非天然型アミノ酸 / チトクロムP450 … More Except Principal Investigator フェレドキシン / マラリア原虫 / アピコプラスト / 相互作用 / タンパク質 / ヘム / グルタミン酸合成酵素 / マラリア / レドックス代謝 / 分子認識 / Tic22 / メチル化 / 等温滴定型熱量計 / X線結晶構造解析 / NMR / 構造生物学 / インシリコスクリーニング / バイオレイヤ干渉法 / タンパク質間相互作用 / 蛋白質間相互作用 / 鉄 / glutamate synhtase / sulfite reductase / ferredoxin:NADP reductase / ferredoxin / redox metabolism / plastid / フェレドキシン:NADP還元酵素 / 亜硫酸還元酵素 / フェレトキシン:NADP還元酵素 / プラスチド / Electron transfer complex / Ferredoxin-NADP^+ reductase / Glutamate Synthase / Ferredoxin / Nitrogen assimilation / Carbon assimilation / 炭素同化 / ラン藻 / シアノバクテリア / 炭酸固定 / フェレドキシンNADP^+還元酵素 / 電子伝達複合体 / フェレドキシン-NADP^+還元酵素 / 窒素同化 / 炭酸同化 / ELECTRON TRANSFER / ARTIFICIAL AMINO ACID / O-O BOND CLEAVAGE / ARTIFICIAL ENZYME / ACID CATALYST / OXYGENATEDFORM / CAMPHOR / CYTOCHROME P450 / 非天然型アミノ酸 / プロトン / 電子伝達 / 人工アミノ酸 / O-O結合開裂反応 / 人工酵素 / 酸触媒 / 酸素化型 / カンファー / チトクロームP450 / 酸化還元電位 / フェレドキシン還元酵素 / フェレドキシン:NADP+還元酵素 / 感染症 / 大腸菌 / プロトンポンプ / 無細胞たんぱく合成 / Paracoccus denitrificans / シトクロム酸化酵素 Less

マラリア原虫のフェレドキシンの変異が薬剤耐性をもたらす機序の解明Principal Investigator
- Principal Investigator
  
  木股洋子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Yamaguchi University
マラリア原虫が持つ植物由来Tic22タンパク質によるペプチド鎖認識機構の解明
- Principal Investigator
  
  齊藤貴士
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Hokkaido University of Science
Anaerobic heme degradation by pathogenic bacteria
- Principal Investigator
  
  Ozaki Shin-ichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Yamaguchi University
Elucidation of the role of ferredoxin mutations in artemisinin resistance in malaria parasitesPrincipal Investigator
- Principal Investigator
  
  Kimata Yoko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Yamaguchi University
Mechanisms of protein transport into the quadruplex membrane organelle of Plasmodium falciparum
- Principal Investigator
  
  Saitoh Takashi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Hokkaido University of Science
Heme transport and degradation by enteric pathogens
- Principal Investigator
  
  Shin-ichi Ozaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Yamaguchi University
Perturbation to the electron transfer and distribution due to the connection between ferredoxin and its partner proteinsPrincipal Investigator
- Principal Investigator
  
  ARIGA YOKO
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
マラリア・アピコプラストのレドックス蛋白質群の探索と機能の解明
- Principal Investigator
  
  長谷俊治
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
マラリア・アピコプラストのレドックス蛋白質群の探索と機能の解明
- Principal Investigator
  
  長谷俊治
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
マラリア・アピコプラストのレドックス蛋白質群の探索と機能の解明
- Principal Investigator
  
  HASE Toshiharu
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Study on the molecular basis for the regulation of redox metabolism network in plastids
- Principal Investigator
  
  HASE Toshiharu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  植物生理
- Research Institution
  Osaka University
部位特異的同位体ラベル法によるシトクロムP450camプロトン輸送経路の解明Principal Investigator
- Principal Investigator
  
  有賀洋子 (木股洋子)
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
Functional design of enzymes for glutamate synthesis and factors involved in cooperative assimilation of carbon and nitrogen
- Principal Investigator
  
  HASE Toshiharu
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  植物生理
- Research Institution
  Osaka University
無細胞たんぱく合成系でのチトクロム酸化酵素の機能発現: 人工アミノ酸の部位特異的導入法を利用したプロトン能動輸送機構の解析を目指して
- Principal Investigator
  
  SHIMADA Hideo
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  Keio University
非天然型アミノ酸の部位特異的導入法によるチトクロムP450アミノ酸残基の役割の証明Principal Investigator
- Principal Investigator
  
  木股洋子
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Keio University
Elucidation for the catalytic function of cytochrome P450cam by site-specific incorporation of natural and unnatural amino acid.
- Principal Investigator
  
  SHIMADA Hideo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  KEIO UNIVERSITY

All 2023 2022 2021 2020 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Inter-domain interaction of ferredoxin-NADP+ reductase important for the negative cooperativity by ferredoxin and NADP(H)2023
- Author(s)
  Kimata-Ariga Yoko、Shinkoda Rina、Abe Ryuya
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 174 Issue: 4 Pages: 327-334
- DOI
  10.1093/jb/mvad046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06557
[Journal Article] Role of Histidine 78 of leaf ferredoxin in the interaction with ferredoxin-NADP+ reductase: regulation of pH dependency and negative cooperativity with NADP(H)2022
- Author(s)
  Kimata-Ariga Yoko、Fukuta Karen、Miyata Masayuki
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 86 Issue: 5 Pages: 618-623
- DOI
  10.1093/bbb/zbac022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06557
[Journal Article] Effect of Artemisinin on the Redox System of NADPH/FNR/Ferredoxin from Malaria Parasites2022
- Author(s)
  Kimata-Ariga Yoko、Morihisa Rena
- Journal Title
  
  Antioxidants
  
  Volume: 11 Issue: 2 Pages: 273-273
- DOI
  10.3390/antiox11020273
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06557
[Journal Article] Molecular mechanism of negative cooperativity of ferredoxin-NADP+ reductase by ferredoxin and NADP(H): role of the ion pair of ferredoxin Arg40 of and FNR Glu1542022
- Author(s)
  Kimata-Ariga Yoko、Nishimizu Yoshiro、Shinkoda Rina
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 172 Issue: 6 Pages: 377-383
- DOI
  10.1093/jb/mvac075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06557
[Journal Article] Functional analyses of Plasmodium ferredoxin Asp97Tyr mutant related to artemisinin resistance of human malaria parasites2021
- Author(s)
  Kimata-Ariga Yoko、Morihisa Rena
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 170 Issue: 4 Pages: 521-529
- DOI
  10.1093/jb/mvab070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06557
[Journal Article] Molecular mechanism of negative cooperativity of ferredoxin-NADP+ reductase by ferredoxin and NADP(H): involvement of a salt bridge between Asp60 of ferredoxin and Lys33 of FNR2021
- Author(s)
  Chikuma Yutaro、Miyata Masayuki、Lee Young-Ho、Hase Toshiharu、Kimata-Ariga Yoko
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 85 Issue: 4 Pages: 860-865
- DOI
  10.1093/bbb/zbaa102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06557
[Journal Article] C-terminal aromatic residue of Plasmodium ferredoxin important for the interaction with ferredoxin: NADP(H) oxidoreductase: possible involvement for artemisinin resistance of human malaria parasites2020
- Author(s)
  Kimata-Ariga Yoko、Sakamoto Asako、Kamatani Miho、Saitoh Takashi、Hase Toshiharu
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 168 Issue: 4 Pages: 427-434
- DOI
  10.1093/jb/mvaa060
- NAID
  40022393407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06557
[Journal Article] Multiple complexes of nitrogen assimilatory enzymes in spinach chloroplasts: possible mechanisms for the regulation of enzyme function.2014
- Author(s)
  Yoko Kimata-Ariga, Toshiharu Hase
- Journal Title
  
  PLOS ONE
  
  Volume: 9(10) Issue: 10 Pages: e108965-e108965
- DOI
  10.1371/journal.pone.0108965
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23570165
[Journal Article] Concentration-dependent oligomerization of cross-linked complexes between ferredoxin and ferredoxin-NADP+ reductase2013
- Author(s)
  Yoko Kimata-Ariga, Hisako Kubota-Kawai, Young-Ho Lee, Norifumi Muraki, Takahisa Ikegami, Genji Kurisu, Toshiharu Hase
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: in press Issue: 4 Pages: 867-872
- DOI
  10.1016/j.bbrc.2013.04.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570165, KAKENHI-PROJECT-24370021, KAKENHI-PROJECT-25870407
[Presentation] フェレドキシン:NADP+還元酵素のドメイン間相互作用（Asp104-Arg178イオン結合）が、NADPHによるアロステリックなフェレドキシンとの親和性抑制に重要である Interdomain interaction of ferredoxin:NADP+ reductase (Asp104-Arg178 ionic bond) important for the allosteric suppression of the affinity with ferredoxin by NADP(H)2023
- Author(s)
  木股洋子、新小田里奈、安部龍哉
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K06557
[Presentation] フェレドキシン:NADP+還元酵素とフェレドキシンとの親和性を、NADP(H)がアロステリックに抑制する分子メカニズム Molecular mechanism by which NADP (H) allosterically suppresses the affinity between ferredoxin:NADP+reductase and ferredoxin2022
- Author(s)
  木股洋子、宮田昌幸、福田カレン、新小田里奈、西水禎朗
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K06557
[Presentation] アルテミシニン耐性に関与するマラリア原虫フェレドキシン変異体の機能解析2021
- Author(s)
  木股洋子、森久鈴菜、齊藤貴士、新小田里奈、西水禎朗
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K06557
[Presentation] マラリア原虫フェレドキシンとフェレドキシン-NADP(H)酸化還元酵素との結合に重要な芳香族アミノ酸残基間相互作用：アルテミシニン耐性との関連性2020
- Author(s)
  木股洋子、坂本麻沙子、鎌谷美穂、森久鈴菜、齊藤貴士
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K06557
[Presentation] フェレドキシンとそのパートナー酵素間の電子伝達における蛋白質界面の役割2013
- Author(s)
  木下岬、有賀（木股）洋子、長谷俊治
- Organizer
  IPR Retreat
- Place of Presentation
  兵庫県、淡路島夢舞台
- Data Source
  KAKENHI-PROJECT-23570165
[Presentation] フェレドキシンとその依存酵素SiRとFNRへの電子伝達様式の差異を生み出す43Serの1アミノ酸置換による解析2012
- Author(s)
  木下岬, 有賀（木股）洋子, 榊原由紀子, 長谷俊治
- Organizer
  日本生化学会大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-23570165
[Presentation] Fd-FNRクロスリンク複合体の構造と電子伝達機能の解析2011
- Author(s)
  有賀洋子（木股洋子）
- Organizer
  日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府）
- Data Source
  KAKENHI-PROJECT-23570165
[Presentation] Ferredoxin と ferredoxin-NADP+ reductaseの複合体形成における疎水性相互作用の役割
- Author(s)
  木下岬、李映昊、後藤祐児、長谷俊治、有賀（木股）洋子
- Organizer
  日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-23570165
[Presentation] ヒトマラリア原虫のフェレドキシンとフェレドキシン:NADP+酸化還元酵素間の相互作用について
- Author(s)
  湯浅翔平、長谷俊治、有賀（木股）洋子
- Organizer
  日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-23570165
[Presentation] 葉緑体における窒素同化系酵素群の高分子量複合体形成とそのダイナミクス
- Author(s)
  有賀（木股）洋子、長谷俊治
- Organizer
  日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-23570165

1. HASE Toshiharu (00127276)

# of Collaborated Projects: 6 results

# of Collaborated Products: 7 results
2. Shin-ichi Ozaki (40280581)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. Saitoh Takashi (00432914)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
4. KURISU Genji (90294131)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. 永野真吾 (60286440)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SHIMADA Hideo (80095611)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. FUJITA Yuichi (80222264)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. EGAWA Tuyoshi (10232935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MUKAI Kuniaki (80229913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HIROSE Tadaaki (60051405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KUSUNOKI Masami (90135749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 阿座上弘行 (40263850)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 樋口恒彦 (50173159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 湯山育子 (80565995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KINOSHITA Misaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Kimata Yoko 木股 洋子

有賀洋子

ARIGA YOKO 有賀 洋子(木股洋子)

有賀 洋子 アリガ ヨウコ

木股 洋子

有賀 洋子(木股洋子) アリガ ヨウコ

ARIGA Yoko 有賀 洋子

KIMATA Yoko 木股 洋子

Research Projects

Research Products

Co-Researchers

マラリア原虫のフェレドキシンの変異が薬剤耐性をもたらす機序の解明Principal Investigator

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Elucidation of the role of ferredoxin mutations in artemisinin resistance in malaria parasitesPrincipal Investigator

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Perturbation to the electron transfer and distribution due to the connection between ferredoxin and its partner proteinsPrincipal Investigator

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部位特異的同位体ラベル法によるシトクロムP450camプロトン輸送経路の解明Principal Investigator

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Principal Investigator

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Kimata Yoko 木股洋子

ARIGA YOKO 有賀洋子(木股洋子)

有賀洋子アリガヨウコ

木股洋子

有賀洋子(木股洋子) アリガヨウコ

ARIGA Yoko 有賀洋子

KIMATA Yoko 木股洋子