OKAMOTO Ken 岡本研

… Alternative Names

岡本研オカモトケン

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Researcher Number	60267143
Other IDs
External Links
Affiliation (Current)	2025: 東京大学, 大学院農学生命科学研究科(農学部), 特任研究員
Affiliation (based on the past Project Information) *help	2017: 日本医科大学, 医学部, 助教授 2007 – 2016: Nippon Medical School, 医学部, Assoc.Professor 2005 – 2006: 日本医科大学, 医学部, 助教授 2004: 日本医科大学, 医学部, 講師 1997 – 2003: 日本医科大学, 医学部, 助手 1999: NIPPON MEDICAL SCHOOL, BIOCHEMISTRY AND MOLECULAR BIOLOGY, Lecturer, 医学部, 講師 1995: Nippon Medical school, Biochemistry and Molecular Biology, Professer, 医学部, 助手
Review Section/Research Field	Principal Investigator Pathological medical chemistry / General medical chemistry / General medical chemistry Except Principal Investigator Functional biochemistry / Biological Sciences / Biophysics / Pathological medical chemistry / Chemistry related to living body / Structural biochemistry / Neuroscience in general
Keywords	Principal Investigator キサンチン酸化酵素 / キサンチン脱水素酵素 / キサンチン酸化還元酵素 / 活性酸素 / 抗痛風薬 / 阻害剤 / X線結晶構造解析 / xanthine dehydrogenase / febuxostat / brain ischemia … More / repurfusion injury / xanthine oxidase / 一酸化窒素 / 脳虚血 / 全脳虚血 / 虚血再灌流障害 / モリブデン酸素 / 酸化酵素型-脱水素酵素型変換 / ノックインマウス / モリブデン酵素 / フラビン酵素 / キサンチチン脱水素酵素 / キサンチチン酸化酵素 / トランスジェニックマウス / スーパーオキシド / 分子病態学 / X線結晶構造 / エックス線結晶構造 / 構造ベース創薬 / 部位特異的変異法 / iron-sulfur center / 鉄硫黄中心 … More Except Principal Investigator キサンチン酸化酵素 / キサンチン脱水素酵素 / 活性酸素 / xanthine dehydrogenase / flavoprotein / ALS / 非ヘム鉄 / X線結晶解析 / 金属フラビン酵素 / xanthine oxidase / 金属タンパク質 / フラビン酵素 / non-heme iron / Xanthine Dehydrogenase / Xanthine Oxidase / EPR / フリーラジカル / NO合成酵素 / 鉄結合タンパク質 / ペルオキシレドキシン / 創薬 / フェブキソスタット / 阻害剤 / 痛風治療薬 / キサンチン / 分子動力学 / 構造・機能予測 / 酸化還元酵素 / 結晶構造 / nNOS / 抗高尿酸血症治療薬 / タンパク質凝集 / 筋萎縮性側索硬化症 / 高尿酸血症治療薬 / プリンサルベージ回路 / キサンチン酸化還元酵素 / 阻害剤による治療薬 / XOR酵素阻害剤 / COVID-19 / XOR阻害剤 / アルツハイマー病 / 神経変性疾患 / x-ray crystallography / Molecular dynamics / Xanthine oxidase / Anti-gout drug / Three-dimensional-structure based drug design / キサンチン脱水素酸素 / モリブデン配位子 / X-線結晶構造 / モリブデン水酸化機構 / モリブデン金属 / 蛋白質の基準振動計算 / X線結晶構造解析 / 蛋白質の基準振動検査 / キサンチンオキシダーゼ / 抗痛風薬 / 蛋白質の立体構造に基づく創薬 / Iron-binding protein / Peroxiredoxin / Non-heme iron / X-ray crystallography / Metallo protein / Active Oxygen / superoxide anion / active oxygen / molybdenum enzyme / xnathine oxidase / X-ray crystal structure / 部位特異的変異法 / X-線結晶解析 / スーパーオキシド / モリブデン酵素 / heme binding protein / peroxiredoxin / metallo-protein / niric oxide synthase / reactive oxygen species / super oxide anion / nitric oxide / free radical / metalloprotein / Flavoprotein / X線結晶構造 / 電子スピン共鳴 / セロビオース脱水素酵素 / superoxide dismutase / 分子内伝達 / パルスラジオリシス / CDNA発見 / 変異型酵素 / cDNA発現 / スーパーオキシドデイスムターゼ / スーパーオキシドデスムターゼ / Super oxide demstase / BOF / ｷｻﾝﾁﾝ / キサシチン脱水素酵素 / スーパーオキサイドセンサー / 情報スウィチ蛋白質 / 金属リセプター / スーパーオキシサイドセンサー / NOセンサー / O_2センサー / COセンサー / 情報スイッチ蛋白質 / 情報伝達金属タンパク質 / 余属リセプター / 金属タンパク / heme / Ca / sinal transduction / hitric oxide Less

Mechanism of effectof XOR inhibitors on delay of progress of neurodegenerative diseases
- Principal Investigator
  
  Nishino Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Tokyo Health Sciences
  The University of Tokyo
The gout medicine which has strong effects on mammalian XOR but not on bacterial XOR: dynamics of the interaction between enzyme XOR and its inhibitor BOF
- Principal Investigator
  
  Kikuchi Hiroto
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Nippon Medical School
Systemic and long term analysys of O2- hyperproduction micePrincipal Investigator
- Principal Investigator
  
  OKAMOTO Ken
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nippon Medical School
The study on the structure-based inhibitor mechanism for xanthine oxidoreductase: beyond a lock-key system
- Principal Investigator
  
  KIKUCHI Hiroto
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Nippon Medical School
Phasogenesis study of XOR mutant knock-in mouse.Principal Investigator
- Principal Investigator
  
  OKAMOTO Ken, 西野朋子
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nippon Medical School
Molecular basis of structure-based drug designPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Ken
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Nippon Medical School
Determination of fine structure of the molybdo-enzyme and mechanism of hydroxylation and protein vibration.
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Nippon Medical School
複反応中心をもつ金属フラビン蛋白群の構造と機能
- Principal Investigator
  
  西野朋子
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nippon Medical School
X線結晶構造解析及び、部位特異的変異法によるキサンチン脱水素酵素の構造・機能の研究Principal Investigator
- Principal Investigator
  
  岡本研
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nippon Medical School
Structure and function complex flavo-proteins which produce free radicals
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  NIPPON MEDICAL SCHOOL
複反応中心をもつ金属フラビソ蛋白群の構造と機能
- Principal Investigator
  
  NISHINO Tomoko
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Nippon Medical School
  Yokohama City University
金属が関与するセンサーとスイッチのケミカルバイオロジー
- Principal Investigator
  
  西野武士
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nippon Medical School
キサンチン酸化酵素における非ヘム鉄の機能に関する研究Principal Investigator
- Principal Investigator
  
  岡本研
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Nippon Medical School
The structure and function of a complex metalloflavoprotein
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Nippon Medical School
小脳におけるパルス状一酸化窒素発生の分子機構
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neuroscience in general
- Research Institution
  Nippon Medical School
Structures and functions of metalloflavoenzymes which produce free radicals
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Functional biochemistry
- Research Institution
  NIPPON MEDICAL SCHOOL
Electron transport system on complex flavoprotein
- Principal Investigator
  
  ABE Yasuko
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Department of Biochemistry and Molecular Biology

[Book] Metallobiology2017
- Author(s)
  T. Nishino, K. Okamoto and S. Leimkuehler
- Total Pages
  47
- Publisher
  Royal Society Press, London
- Data Source
  KAKENHI-PROJECT-15H04702
[Book] RSC Metallobiology Series No. 5, Molybdenum and Tungsten Enzymes:Biochemistry Edited by Russ Hille, Carola Schulzke, and Martin L.Kirk2017
- Author(s)
  Takeshi Nishino, Ken Okamoto, and Silke Leimkuhler
- Publisher
  the Royal Society of Chemistry
- Data Source
  KAKENHI-PROJECT-26440081
[Book] Hand book of flavoproteins Volume 2 (Hille R, Miller S M, Palfey B editors); （分担）The xanthine oxidoreductase enzyme family: xanthine dehydrogenase, xanthine oxidase, and aldehyde oxidase2013
- Author(s)
  Nishino T, Okamoto K, Eger B T, Pai E F
- Publisher
  de Gruyter, Germany
- Data Source
  KAKENHI-PROJECT-23570198
[Book] The xanthine oxidoreductase enzyme family : xanthine dehydrogenase, xanthine oxidase, and aldehyde oxidase. Hand book of flavoproteins Volume 2 (Hille R, Miller S M, Palfey B editors)2013
- Author(s)
  T. Nishino, K. Okamoto, B. T. Eger, E. F. Pai.
- Publisher
  de Gruyter (Germany)
- Data Source
  KAKENHI-PROJECT-23570198
[Book] Hand book of flavoproteins Volume 22013
- Author(s)
  Nishino T, Okamoto K, Eger B T, Pai E F
- Total Pages
  22
- Publisher
  de Gruyter, Germany
- Data Source
  KAKENHI-PROJECT-24590393
[Book] A new-generation uric acid production inhibitor: Febuxostat. In: Fischer J, Ganellin CR, Rotella DP editors. Analogue-based Drug Discovery III.2012
- Author(s)
  Okamoto K, Kondo S, Nishino T.
- Total Pages
  12
- Publisher
  Wiley-VCH (Germany)
- Data Source
  KAKENHI-PROJECT-23570198
[Book] A new-generation uric acid production inhibitor : Febuxostat. In : Fischer J, Ganellin CR, Rotella DP editors. Analogue-based Drug Discovery III.2012
- Author(s)
  K. Okamoto, S. Kondo, T. Nishino.
- Publisher
  Wiley-VCH (Germany)
- Data Source
  KAKENHI-PROJECT-23570198
[Book] A new-generation uric acid production inhibitor: Febuxostat. in Analogue-based Drug Discovery III2012
- Author(s)
  Okamoto K, Kondo S, Nishino T
- Total Pages
  12
- Publisher
  Wiley-VCH
- Data Source
  KAKENHI-PROJECT-24590393
[Book] The Mammalian Xanthine Oxidoreductase : Mechanisms of Hydroxylation Reaction and Dehydrogenase/Oxidase Conversion (FLAVINS AND FLAVOPROTEINS 2005)2005
- Author(s)
  Ken Okamoto et al.
- Total Pages
  12
- Data Source
  KAKENHI-PROJECT-16205021
[Book] FLAVINS AND FLAVOPROTEINS 20052005
- Author(s)
  Ken Okamoto, et al
- Total Pages
  12
- Publisher
  ARchiTect.Inc.
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Book] Flavins and Flavoproteins : The mechanism of Conversion from Xanthine Dehydrogenase to Oxidase of Rat Enzyme Studied by Site-Directed Mutagenesis. (S.Ghisla et al., eds.)1999
- Author(s)
  T.Nishino, K.Okamoto, H.Hori, A.Kounosu, T.Nishino
- Total Pages
  4
- Publisher
  RUDOLF WEBER AGENCY FOR SCIENTIFIC PUBLICATIONS
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Book] Flavins and Flavoproteins : Crystal structure of xanthine oxidreductase and EPR assignment of Fe/S center. (S.Ghisla et al., eds.)1999
- Author(s)
  C.Enroth, B.T.Eger, E.F.Pai, K.Okamoto, T.Iwasaki, T.Nishino, T.Nishino
- Total Pages
  4
- Publisher
  RUDOLF WEBER AGENCY FOR SCIENTIFIC PUBLICATIONS
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] The C-terminal Peptide Plays a Role in the Formation of an Intermediate Form during the Transition between Xanthine Dehydrogenase and Xanthine Oxidase2015
- Author(s)
  Tomoko Nishino, Ken Okamoto, Yuko Kawaguchi, Tomohiro Matsumura, Bryan T. Eger, Emil F. Pai, Takeshi Nishino
- Journal Title
  
  FEBS　J
  
  Volume: Apr13 Issue: 16 Pages: 1-16
- DOI
  10.1111/febs.13277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590393
[Journal Article] Evaluation of Neuronal Protective Effects of Xanthine Oxidoreductase Inhibitors on Severe Whole-brain Ischemia in Mouse Model and Analysis of Xanthine Oxidoreductase Activity in the Mouse Brain2015
- Author(s)
  Suzuki G, Okamoto , Kusano T, Matsuda Y, Fuse A, Yokota H.
- Journal Title
  
  Neurol. Med. Chir.(Tokyo)
  
  Volume: 55 Issue: 1 Pages: 77-85
- DOI
  10.2176/nmc.oa.2013-0307
- NAID
  130004922260
- ISSN
  0470-8105, 1349-8029
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590393
[Journal Article] Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout.2015
- Author(s)
  Nishino T, Okamoto K.
- Journal Title
  
  J Biol Inorg Chem.
  
  Volume: 20 Issue: 2 Pages: 195-207
- DOI
  10.1007/s00775-014-1210-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590393, KAKENHI-PROJECT-26440081
[Journal Article] The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice2015
- Author(s)
  M. Yamaguchi,K. Okamoto, T. Kusano, Y. Matsuda, G. Suzuki, A. Fuse, H. Yokota.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 7 Pages: e0133980-e0133980
- DOI
  10.1371/journal.pone.0133980
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26440081
[Journal Article] Chemical Nature and Reaction Mechanisms of the Molybdenum Cofactor of Xanthine Oxidoreductase2013
- Author(s)
  K. Okamoto, T. Kusano, T. Nishino.
- Journal Title
  
  Curr. Pham. Des.
  
  Volume: 19 Issue: 14 Pages: 2606-2614
- DOI
  10.2174/1381612811319140010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570198, KAKENHI-PROJECT-24590393, KAKENHI-PROJECT-24659144
[Journal Article] Role of N-glycosylation of human lysosomal phospholipase A2 for the formation of catalytically active enzyme.2013
- Author(s)
  Hiraoka M, Okamoto K, Ohguro H, Abe A
- Journal Title
  
  J Lipid Res
  
  Volume: 54 Issue: 11 Pages: 3098-3105
- DOI
  10.1194/jlr.m041640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590393, KAKENHI-PROJECT-25462723
[Journal Article] キサンチン酸化還元酵素研究110年 ― 酵素蛋白お哺乳類における多面性 ;デヒドロゲナーゼからオキシダーゼへの変換とキサンチン酸化還元酵素が触媒するさまざまな反応 ―2013
- Author(s)
  岡本研
- Journal Title
  
  高尿酸血症と痛風
  
  Volume: 21 Pages: 69-74
- Data Source
  KAKENHI-PROJECT-23570198
[Journal Article] キサンチン酸化還元酵素研究110年　－酵素蛋白の哺乳類における多面性；デヒドロゲナーゼからオキシダーゼへの変換とキサンチン酸化還元酵素が触媒するさまざまな反応－2013
- Author(s)
  岡本研
- Journal Title
  
  高尿酸血症と痛風
  
  Volume: 21 Pages: 69-74
- Data Source
  KAKENHI-PROJECT-23570198
[Journal Article] Chemical Nature and Reaction Mechanisms of the Molybdenum Cofactor of Xanthine Oxidoreductase.2013
- Author(s)
  Okamoto K, Kusano K, Nishino T
- Journal Title
  
  Curr Pharm Des
  
  Volume: 19 Pages: 2006-2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590393
[Journal Article] Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans.2012
- Author(s)
  Ichida K, Amaya Y, Okamoto K, Nishino T.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 13 Issue: 11 Pages: 15475-15495
- DOI
  10.3390/ijms131115475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590393, KAKENHI-PROJECT-24659144
[Journal Article] Protein conformational gating of enzymatic activity in xanthine oxidoreductase2012
- Author(s)
  H. Ishikawa, B. T. Eger, K. Okamoto, T. Nishino, E. F. Pai.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 134 Issue: 2 Pages: 999-1009
- DOI
  10.1021/ja207173p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570198
[Journal Article] Different inhibitory potency of febuxostat towards mammalian and bacterial xanthine oxidoreductases: insight from molecular dynamics2012
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K.Okamoto, S. Leimkuhler, and T. Nishino
- Journal Title
  
  Scientific Reports
  
  Volume: 2 Issue: 1 Pages: 331-331
- DOI
  10.1038/srep00331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22540421, KAKENHI-PROJECT-23570198
[Journal Article] 理論生物物理と生化学を組み合わせた薬物研究―キサンチン酸化還元酵素と阻害剤フェブキソスタットの結合機序―2012
- Author(s)
  藤崎弘士, 古田忠臣, 岡本研, 菊地浩人
- Journal Title
  
  日本医科大学医学会誌
  
  Volume: 8 Pages: 222-227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570198
[Journal Article] 理論生物物理と生化学を組み合わせた薬効研究―キサンチン酸化還元酵素と阻害剤フェブキソスタットの結合機序―2012
- Author(s)
  藤崎弘士, 古田忠臣, 岡本研, 菊地浩人
- Journal Title
  
  日本医科大学医学会誌
  
  Volume: 8 Pages: 222-227
- NAID
  130004471511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570198
[Journal Article] FYX-051 : a novel and potent hybrid-type inhibitor of xanthine oxidoreductase.2011
- Author(s)
  Matsumoto K, Okamoto K, Ashizawa N, Nishino T.
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 336 Pages: 95-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] FYX-051 : a novel and potent hybrid-type inhibitor of xanthine oxidoreductase.2011
- Author(s)
  Matsumoto K, Okamoto K, Ashizawa N, Nishino T
- Journal Title
  
  J Pharmacol Exp Ther. Jan ; 336(1)
  
  Pages: 95-103
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] 新世代の尿酸生成抑制剤フェブキソスタット2010
- Author(s)
  岡本研
- Journal Title
  
  薬理と治療
  
  Volume: 38 Pages: 955-962
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase : Substrate Orientation and Structure of the Key Reaction Intermediate.2010
- Author(s)
  Okamoto K, Kawaguchi Y, Eger BT, Pai EF, Nishino T.
- Journal Title
  
  J Am Chem Soc.
  
  Volume: 132 Pages: 17080-17083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] Ken Okamoto and Takeshi Nishino (2008) Crystal structures of mammalian xanthine oxidoreductase bound with various inhibitors : allopurinol, febuxostat, and FYX-051.2008
- Author(s)
  Ken Okamoto, Takeshi Nishino
- Journal Title
  
  J Nippon Med Sch. 75
  
  Pages: 2-3
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] Crystal structures of mammalian xanthine oxidoreductase bound with various inhibitors : allopurinol, febuxostat, and FYX-0512008
- Author(s)
  Okamoto K, Nishino T
- Journal Title
  
  J Nippon Med Sch. Feb ; 75(1)
  
  Pages: 2-3
- NAID
  130004057313
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] Mechanism of inhibition of xanthine oxidoreductase by allopurinol : crystal structure of reduced bovine milk xanthine oxidoreductase bound withoxipurinol.2008
- Author(s)
  Okamoto K.
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids 27
  
  Pages: 888-893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] Mammalian xanthine oxidoreductase-mechanism of transition from xanthine ehydrogenase to xanthine oxidase.2008
- Author(s)
  Nishino T, Okamoto K, Eger BT, Pai EF, Nishino T
- Journal Title
  
  FEBS J. Jul ; 275(13)
  
  Pages: 3278-89
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] Structure and mechanism of molybdenum hydroxylase2008
- Author(s)
  Okamoto K, Nishino T.
- Journal Title
  
  [Article in Japanese]Seikagaku. Jun ; 80(6)
  
  Pages: 531-9
- NAID
  10021192278
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] モリブデンによる水酸化反応中間体の構造と反応機構2008
- Author(s)
  岡本研、西野武士
- Journal Title
  
  生化学 80
  
  Pages: 531-539
- NAID
  10021192278
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] Mammalian xanthine oxidoreductase- mechanism of transition from xanthine dehydrogenase to xanthine oxidase2008
- Author(s)
  Nishino Tomoko, Okamoto Ken, Eger Bryan T, Pai Emil F, Nishino Takeshi
- Journal Title
  
  FEBS J 275
  
  Pages: 3278-3289
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] Crystal structures of mammalian xanthine oxidoreductase bound with various inhibitors : allopurinol, febuxostat, and FYX-0512008
- Author(s)
  Ken Okamoto and Takeshi Nishino
- Journal Title
  
  J Nippon Med Sch 75
  
  Pages: 2-3
- NAID
  130004057313
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] Mechanism of inhibition of xanthine oxidoreductase by allopurinol : crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol2008
- Author(s)
  Okamoto K, Eger BT, Nishino T, Pai EF, Nishino T
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids 6
  
  Pages: 888-893
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] Dimer-oligomer interconversion of wild-type and mutant rat 2-Cys peroxiredoxin : disulfide formation at dimer-dimer interfaces is not essential for decamerization2008
- Author(s)
  Matsumura T, Okamoto K, Iwahara S, Hori H, Takahashi Y, Nishino T, Abe Y
- Journal Title
  
  J Biol Chem 283
  
  Pages: 284-293
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] 尿酸生成抑制薬2008
- Author(s)
  岡本研
- Journal Title
  
  日本臨床 66
  
  Pages: 748-753
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] Mechanism of inhibition of xanthine oxidoreductase by allopurinol : crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol.2008
- Author(s)
  Okamoto K, Eger BT, Nishino T, Pai EF, Nishino T
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids. Jun ; 27(6)
  
  Pages: 888-93
- Data Source
  KAKENHI-PROJECT-20590317
[Journal Article] Crystal Structures of Mammalian Xanthine Oxidoreductase Bound with Various Inhibitors: Allopurinol, Febuxostat, and FYX-0512008
- Author(s)
  Ken Okamoto
- Journal Title
  
  Journal of Nippon Medical School 75
  
  Pages: 2-3
- NAID
  130004057313
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] モリブデンによる水酸化反応中間体の構造と反応機構2008
- Author(s)
  岡本研, 西野武士
- Journal Title
  
  生化学 80
  
  Pages: 531-539
- NAID
  10021192278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] Dimer-oligomer interconversion of wild-type and mutant rat2-Cys peroxiredoxin : disulfide formation at dimer-dimer interfaces is not essential for decamerization.2008
- Author(s)
  Matsumura T, Okamoto K, Iwahara S, Hori H, Takahashi Y, Nishino T, Abe Y
- Journal Title
  
  J Biol Chem. 283
  
  Pages: 284-293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] Mechanism of inhibition of xant allopurinol : crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol.2008
- Author(s)
  Okamoto K, Eger BT, Nishino T, Pai EF, Nishino T
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids. 6
  
  Pages: 888-893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase2007
- Author(s)
  Asai R, Nishino T, Matsumura T, Okamoto K, Igarashi K, Pai EF, Nishino T
- Journal Title
  
  J Biochem 141
  
  Pages: 525-534
- NAID
  10020100130
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] 結晶構造からみた尿酸生成抑制剤の阻害機構2007
- Author(s)
  岡本研
- Journal Title
  
  日医大医会誌 3
  
  Pages: 83-88
- NAID
  130004941884
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site : roles of active site residues in binding and activation of purine substrate2007
- Author(s)
  Yamaguchi Y, Matsumura T, Ichida K, Okamoto K, Nishino T
- Journal Title
  
  J Biochem 141
  
  Pages: 513-524
- NAID
  10020100078
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] Mechanism of formation of active oxygen species in XOR : Molecular basis of redox signaling2006
- Author(s)
  Ken Okamoto
- Journal Title
  
  Experimental Medicine. 24
  
  Pages: 1724-1730
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Journal Article] XORによる活性酸素生成機構 : レドックスシグナル発生の分子基盤2006
- Author(s)
  岡本研
- Journal Title
  
  実験医学 24・12
  
  Pages: 1724-1730
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] XORによる活性酸素生成機構:レドックスシグナル発生の分子基盤2006
- Author(s)
  岡本研
- Journal Title
  
  実験医学 24・12
  
  Pages: 1724-1730
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16205021
[Journal Article] XORによる活性酸素生成機構 : レドックスシグナル発生の分子基盤2006
- Author(s)
  岡本研
- Journal Title
  
  実験医学 24・12
  
  Pages: 1724-1730
- Data Source
  KAKENHI-PROJECT-16205021
[Journal Article] 酵素のかたちにあわせた痛風治療薬(特集タンパク質のかたちと病気)2006
- Author(s)
  岡本研、西野武士
- Journal Title
  
  バイオニクス 3
  
  Pages: 36-41
- NAID
  40007250647
- Data Source
  KAKENHI-PROJECT-18590276
[Journal Article] The Mammalian Xanthine Oxidoreductase : Mechanisms of Hydroxylation Reaction and Dehydrogenase / Oxidase Conversion2005
- Author(s)
  Ken Okamoto
- Journal Title
  
  FLAVINS AND FLAVOPROTEINS 2005(ARchi Tect Inc.)
  
  Pages: 379-390
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Journal Article] The crystal structure of xanthine oxidoreductase during catalysis : Implications forreaction mechanism and enzyme inhibition2004
- Author(s)
  Ken Okamoto, et al
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 101(21)
  
  Pages: 7931-7936
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Journal Article] キサンチン脱水素酵素から酸化酵素への蛋白質構造・機能の変換の分子機構2004
- Author(s)
  岡本研, 他
- Journal Title
  
  蛋白質核酸酵素 49・5
  
  Pages: 625-633
- Data Source
  KAKENHI-PROJECT-16205021
[Journal Article] The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition2004
- Author(s)
  ken Okamoto et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 101・21
  
  Pages: 7931-7936
- Data Source
  KAKENHI-PROJECT-16205021
[Journal Article] The crystal structure of xanthine oxidoreductase during catalysis : Implications for reaction mechanism and enzyme inhibition2004
- Author(s)
  Ken Okamoto, et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 101・21
  
  Pages: 7931-7936
- Data Source
  KAKENHI-PROJECT-12147207
[Journal Article] The crystal structure of xanthine oxidoreductase duing catalysis : Implications forreaction mechanism and enzyme inhibition2004
- Author(s)
  Ken Okamoto, et al
- Journal Title
  
  Proc.Natl.Acad.Sci.USA. 101・21
  
  Pages: 7931-7936
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16205021
[Journal Article] Purification, crystallization and preliminary X-ray siffraction studies of xanthine dehydrogebse and xanthine oxidase isolated from bovine milk.2000
- Author(s)
  B.T.Eger, K.Okamoto, C.Enroth, M.Sato, T.Nishino, E.F.Pai, T.Nishino
- Journal Title
  
  Acta Cryst. D56
  
  Pages: 1656-1658
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] The role of the [2Fe-2S] cluster centers in xanthine oxidoreductase.2000
- Author(s)
  T.Nishino, K.Okamoto
- Journal Title
  
  Journal of Inorganic Biochemistry 82
  
  Pages: 43-49
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Sequence Motif-Specific Assignment of Two [2Fe-2S] Clusters in Rat Xanthine Oxidoreductase Studied by Site-Directed Mutagenesis.2000
- Author(s)
  T.Iwasaki, K.Okamoto, T.Nishino, J.Mizushima, H.Hori, T.Nishino
- Journal Title
  
  J.Biochem. 127
  
  Pages: 771-778
- NAID
  10005443636
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Sequence Motif-Specific Assignment of Two [2Fe-2S] Clusters in Rat Xanthine Oxidoreductase Studied by Site-Directed Mutagenesis2000
- Author(s)
  T.Iwasaki, K.Okamoto, T.Nishino, J.Mizushima, H.Hori, T.Nishino
- Journal Title
  
  J.Biochem. 127
  
  Pages: 771-778
- NAID
  10005443636
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] The role of the [2Fe-2S] cluster centers in xanthine oxidoreductase2000
- Author(s)
  T.Nishino, K.Okamoto
- Journal Title
  
  Journal of Inorganic Biochemistry 82
  
  Pages: 43-49
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase : Structure-based mechanism of conversion.2000
- Author(s)
  C.Enroth, B.T.Eger, K.Okamoto, T.Nishino, T.Nishino, E.F.Pai
- Journal Title
  
  Proc.Natle.Acad, Scie., USA 97
  
  Pages: 10723-10728
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Inhibition of Xanthine Oxidase and Xanthine Dehydrogenase by Nitric Oxide.1999
- Author(s)
  K.Ichimori, M.Fukahori, H.Nakazawa, K.Okamoto, Takeshi Nishino
- Journal Title
  
  J.Biol.Chem. 274
  
  Pages: 7763-7768
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Flavins and Flavoproteins (S.Ghisla et al., eds.) : Crystal structure of xanthine oxidreductase and EPR assignment of Fe/S center.1999
- Author(s)
  C.Enroth, B.T.Eger, E.F.Pai, K.Okamoto, T.Iwasaki, T.Nishino, T.Nishino
- Journal Title
  
  RUDOLF WEBER AGENCY FOR SCIENTIFIC PUBLICATIONS
  
  Pages: 4-4
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Flavins and Flavoproteins (S.Ghisla et al., eds.) : The mechanism of Conversion from Xanthine Dehydrogenase to Oxidase of Rat Enzyme Studied by Site-Directed Mutagenesis.1999
- Author(s)
  T.Nishino, K.Okamoto, H.Hori, A.Kounosu, T.Nishino
- Journal Title
  
  RUDOLF WEBER AGENCY FOR SCIENTIFIC PUBLICATIONS
  
  Pages: 4-4
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Inhibition of Xanthine Oxidase and Xanthine Dehydrogenase by Nitric Oxide1999
- Author(s)
  K.Ichimori, M.Fukahori, H.Nakazawa, K.Okamoto, Takeshi Nishino
- Journal Title
  
  J.Biol.Chem. 274
  
  Pages: 7763-7768
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-10044324
[Journal Article] Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase : Substrate Orientation and Structure of the Key Reaction Intermediate.
- Author(s)
  Okamoto K, Kawaguchi Y, Eger BT, Pai EF, Nishino T
- Journal Title
  
  J Am Chem Soc.
  
  Pages: 2010-2010
- Data Source
  KAKENHI-PROJECT-20590317
[Patent] 認知症治療または予防薬2017
- Inventor(s)
  西野武士、加藤信介、加藤雅子、鈴木秀典、岡本研
- Industrial Property Rights Holder
  西野武士、加藤信介、加藤雅子、鈴木秀典、岡本研
- Industrial Property Rights Type
  特許
- Filing Date
  2017-02-17
- Overseas
- Data Source
  KAKENHI-PROJECT-15H04702
[Presentation] プリン型キサンチン酸化還元酵素阻害剤(npXORI)によるアルツハイマー病モデルマウスの病理組織学的抑制効果の証明:アルツハイマー病新規治療薬開発への新戦略2018
- Author(s)
  加藤雅子、加藤信介、岡本研、西野武士
- Organizer
  日本痛風核酸代謝学会
- Data Source
  KAKENHI-PROJECT-15H04702
[Presentation] Regulation of purine metabolism in rabbit reticulocytes2017
- Author(s)
  Mai Sekine, T. Kusano, T. Nishino, K. Nagata, K. Okamoto
- Organizer
  日本生化学会大会
- Data Source
  KAKENHI-PROJECT-15H04702
[Presentation] キサンチンオキシダーぜ阻害薬による臓器保護効果の機構解明2017
- Author(s)
  谷崇、岡本
- Organizer
  日本痛風核酸代謝学会
- Place of Presentation
  東京
- Year and Date
  2017-02-16
- Data Source
  KAKENHI-PROJECT-15H04702
[Presentation] ヒトには効くがバクテリアには効かない痛風薬　ー酵素と阻害剤BOFとの相互作用ダイナミクスー2016
- Author(s)
  菊地浩人、藤崎弘士、古田忠臣、岡本研、西野武士
- Organizer
  日本物理学会2016年秋季大会
- Place of Presentation
  金沢大学角間キャンパス
- Year and Date
  2016-09-13
- Data Source
  KAKENHI-PROJECT-26440081
[Presentation] キサンチン酸化還元酵素基質結合ポケットの動的解析2016
- Author(s)
  岡本研、菊地浩人、藤崎弘士、古田忠臣、西野武士
- Organizer
  第49回日本痛風・核酸代謝学会総会
- Place of Presentation
  大阪
- Year and Date
  2016-02-18
- Data Source
  KAKENHI-PROJECT-26440081
[Presentation] キサンチン酸化還元酵素基質結合ポケットの動的解析2016
- Author(s)
  岡本研,菊地浩人, 藤崎弘士, 古田忠臣, 西野武士
- Organizer
  第49回日本痛風・核酸代謝学会総会
- Place of Presentation
  大阪府千里
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-15H04702
[Presentation] キサンチン酸化還元酵素におけるAsp428はXDH/XO反応を巧妙に調節する重要アミノ酸である2016
- Author(s)
  川口裕子、西野朋子、松村智裕、岡本研、西野武士
- Organizer
  第49回日本痛風・核酸代謝学会総会
- Place of Presentation
  大阪府千里
- Year and Date
  2016-02-19
- Data Source
  KAKENHI-PROJECT-15H04702
[Presentation] キサンチン脱水素酵素(XDH)のNAD+ の結合による反応調節2015
- Author(s)
  川口裕子1, 西野朋子 , 岡本研 , 西野武士
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸市ポートピア
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-15H04702
[Presentation] The role of Asp428 in the reactivity of xanthine dehydrogenase2015
- Author(s)
  Yuko Kawaguchi, Tomoko Nishino, Ken Okamoto, and Takeshi Nishino
- Organizer
  IX. Molybdenum & Tungsten Enzymes Conference 2015
- Place of Presentation
  Baratonfuered, Hungary
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04702
[Presentation] キサンチン酸化還元酵素の基質ガイド機構の解析2015
- Author(s)
  岡本研 , 菊地浩人 , 藤崎弘士 , 古田忠臣 , 西野武士
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸市ポートピア
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15H04702
[Presentation] キサンチン酸化還元酵素の基質ガイド機構の解析2015
- Author(s)
  岡本研、菊地浩人、藤崎弘士、古田忠臣、西野武士
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26440081
[Presentation] On the motion of a loop located in the entrance to the ligand-binding pocket of bacterial XOR with the inhibitor BOF2015
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, T. Nishino.
- Organizer
  53rd Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  Kanazawa
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-26440081
[Presentation] キサンチン脱水素酵素(XDH)のNAD+ の結合による反応調節2015
- Author(s)
  川口裕子、西野朋子、岡本研、西野武士
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26440081
[Presentation] 痛風治療薬と標的酵素の相互作用解析－構造情報は臨床にどう生かされているのか－2014
- Author(s)
  岡本研
- Organizer
  生化学会関東部会
- Place of Presentation
  茨城大学、水戸
- Year and Date
  2014-06-14
- Invited
- Data Source
  KAKENHI-PROJECT-26440081
[Presentation] Molecular Dynamics and Free Energy Analysis of Xanthine Oxidoreductase-Ligand Interactions2013
- Author(s)
  K. Okamoto, H. Kikuchi, H. Fujisaki, T. Furuta, S. Leimkuhler, and T. Nishino.
- Organizer
  2013 Molybdenum & Tungsten Enzymes Conference
- Place of Presentation
  Sintra (Portugal)
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] Mutation studies on the mammalian and the bacterial XORs with inhibitors2013
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, T. Nishino
- Organizer
  The 51st Annual meeting of the Biophysics Society of Japan
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] Mutation studies on the mammalian and the bacterial XORs with inhibitors2013
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, and T. Nishino.
- Organizer
  The 51^<st> Annual Meeting of the Biophysics society of japan
- Place of Presentation
  Kyoto (Jpn)
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] Molecular dynamics simulations and binding free energy analysis of xanthine oxidoreductase-ligand complexes2012
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, and T. Nishino.
- Organizer
  The 50^<st> Annual Meeting of the Biophysics society of Japan
- Place of Presentation
  Nagoya (Japan)
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] Molecular dynamics and free energy analysis of xanthine oxidoreductase-ligand interactions2012
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, and T. Nishino.
- Organizer
  TACC 2012 Theory and Applications of Computational Chemistry
- Place of Presentation
  Pavia (Italy)
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] 抗痛風薬フェブキソスタットとキサンチン酸化還元酵素との相互作用の解析2012
- Author(s)
  岡本研, 菊地浩人, 藤崎弘士, 古田忠臣, 西野武士
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] キサンチン酸化還元酵素に対するファブキソスタットの阻害作用2011
- Author(s)
  菊地浩人, 藤崎弘士, 古田忠臣, 岡本研, 西野武士
- Organizer
  日本物理学会2011年秋季大会
- Place of Presentation
  富山大学
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] キサンチン酸化還元酵素に対するフェブキソスタットの阻害作用2011
- Author(s)
  菊地浩人、藤崎弘士、古田忠臣、岡本研、西野武士
- Organizer
  日本物理学会2011年秋季大会
- Place of Presentation
  富山大学
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] Structure-based inhibitor mechanism of febuxostat for xanthine oxidoreductase : molecular dynamics study2011
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, S. Leimkuhler, and T. Nishino.
- Organizer
  Ninth Triennial Congress of the World Association of Theoretical and Computational Chemists
- Place of Presentation
  Santiago de Compostela (Spain)
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] Reaction mechanism and substrate binding mode of xanthine oxidoreductase.2011
- Author(s)
  Ken Okamoto、Yuko Kawaguchi、Teruo Kusano、Tomohiro Matsumura1、Koji Matsumoto、Takeshi Nishino
- Organizer
  14th International Symposium on Purine and Pyrimidine Metabolism in Man
- Place of Presentation
  東京
- Year and Date
  2011-02-20
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] 14th International Symposium on Purine and Pyrimidine Metabolism in Man Reaction mechanism and substrate binding mode of xanthine oxidoreductase.2011
- Author(s)
  Ken Okamoto、Yuko Kawaguchi、Teruo Kusano、Tomohiro Matsumura 1、Koji Matsumoto、Takeshi Nishino
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] Structure-based inhibitor mechanism of febuxostat for xanthine oxidoreductase: molecular dynamics study2011
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, S. Leimkuhler, and T. Nishino
- Organizer
  Ninth Triennial Congress of the World Association of Theoretical and Computational Chemists
- Place of Presentation
  Santiago de Compostela, Spain
- Data Source
  KAKENHI-PROJECT-23570198
[Presentation] ウシキサンチン酸化還元酵素と天然基質キサンチンとの反応中間体結晶構造Structure of xanthine oxidoreductase in action ; Reaction intermediate structure of milk xanthine oxidoreductase and natural substrate xanthine.2010
- Author(s)
  Ken Okamoto, Tomohiro Matsumura, Kusano Teruo, Koji Matsumoto, Takeshi Nishino
- Organizer
  2010年日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] ブチロフィリンが有す多機能B30.2/SPRYドメインとミルクキサンチン脱水素酵素との結合様式について2009
- Author(s)
  西野朋子, 李穎, 岡本研, 草野輝男, 川口裕子, 松村智裕, 他
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] キサンチン脱水素酵素から酸化酵素に変換する際の遷移状態における構造変2009
- Author(s)
  西野朋子, 岡本研、川口裕子
- Organizer
  蛋白質科学会
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] 新規キサンチン酸化還元酵素阻害剤FYX-051の酵素学的,構造学的解析2009
- Author(s)
  松本浩二, 岡本研
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] キサンチン酸化還元酵素の基質結合様式と基質活性化機構2009
- Author(s)
  岡本研, 松村智裕, 草野輝男, 松本浩二, 西野武士
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] ラットキサンチン脱水素酵素におけるCH...O結合がFADの酸化還元電位に与える影響について2009
- Author(s)
  川口裕子, 西野朋子, 松村智裕, 岡本研, 西野武士
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] キサンチン酸化還元酵素の基質結合様式と基質活性化機構2009
- Author(s)
  西野朋子, 岡本研、川口裕子
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] ラットキサンチン脱水素酵素における機能的CH...O水素結合の存在2009
- Author(s)
  川口裕子, 西野朋子, 松村智裕, 岡本研, 西野武士
- Organizer
  第9回蛋白質科学会年会
- Place of Presentation
  熊本
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] 新規キサンチン酸化還元酵素剤FYX-051の酵素学的,構造生物学的解析2009
- Author(s)
  松本浩二, 岡本研, 松村智裕, 草野輝男, 西野武士
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] キサンチン脱水素酵素から酸化酵素に変換する際の遷移状態に於ける二量体サブユニット構造の非対称性2009
- Author(s)
  西野朋子, 岡本研, 川口裕子, 辻井厚子, 他
- Organizer
  第9回蛋白質科学会年会
- Place of Presentation
  熊本
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] Substrate Binding Mode of Xanthine Oxidoreductase2008
- Author(s)
  Ken Okamoto, Tomohiro Matsumura, Kusano Teruo, Koji Matsumoto, Takeshi Nishino
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-18590276
[Presentation] 結晶構造から見たキサンチン酸化還元酵素阻害剤の阻害機構の解明2008
- Author(s)
  岡本研
- Organizer
  日本痛風核酸代謝学会学会賞受賞講演
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] キサンチン酸化還元酵素の基質結合様式と反応機構キサンチン脱水素酵素/酸化酵素の変換における二量体構造の非2008
- Author(s)
  岡本研
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] 結晶構造から見たキサンチン酸化還元酵素阻害剤の阻害機構の解明2008
- Author(s)
  岡本研
- Organizer
  第41回痛風核酸代謝学会学会賞受賞講演
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-18590276
[Presentation] Structure basis for mechanism of inhibition of xanthine oxidoreductase2008
- Author(s)
  Ken Okamoto
- Organizer
  41^<th> Annual meeting for gout and nucleic acid metabolism
- Place of Presentation
  Fukui
- Year and Date
  2008-02-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] 結晶構造から見たキサンチン酸化還元酵素阻害剤の阻害機構の解明2008
- Author(s)
  岡本研
- Organizer
  第41回日本痛風・核酸代謝学会
- Place of Presentation
  福井
- Year and Date
  2008-02-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] Potent inhibitors of xanthine oxidoreductase : Mechansims of inhibition and crystal structures of the enzyme-inhibitor complexes2007
- Author(s)
  Okamoto, K.
- Organizer
  12th International Symposium on Purine and Pyrimidine Metabolism in Man
- Place of Presentation
  Chikago USA
- Data Source
  KAKENHI-PROJECT-18590276
[Presentation] Potent Inhibitors of Xanthine Oxidoreductase: Mechanisms of Inhibition and Crystal Structures of the Enzyme-Inhibitor Complexes.2007
- Author(s)
  Ken Okamoto
- Organizer
  International congress of purine and pyrimidine methabolism in man.
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-18590276
[Presentation] キサンチン酸化還元酵素の基質結合様式と周囲残基の機能2007
- Author(s)
  岡本研
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] Ligand Binding Structures of Mammalian Xanthine Oxidoreductase : Implications for Hydroxylation Mechanism.2007
- Author(s)
  Ken Okamoto
- Organizer
  Goodon Research Conferences(Molybdenum & Tungstem Enzymes)
- Place of Presentation
  アメリカ
- Year and Date
  2007-07-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] Potent inhibiors of xanthine oxidoreductase : Mechansims of inhibition and crystal structures of the enzyme-inhibitor complexes2007
- Author(s)
  Ken Okamoto
- Organizer
  12th International Symposiumj on Purine and Pyrimidine Metabolism in Man
- Place of Presentation
  アメリカ
- Year and Date
  2007-06-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] Potent inhibitors of xanthine oxidoreductase: Mechansims of inhibition and crystal structures of the enzyme-inhibitor complexes2007
- Author(s)
  Ken Okamoto
- Organizer
  12th International Symposium on Purine and Pyrimidine Metabolism in Man
- Place of Presentation
  アメリカシカゴ
- Year and Date
  2007-06-24
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] X-ray structural and molecular biological analyses of various species of xanthine oxidase(dehydrogenase)2007
- Author(s)
  Ken Okamoto
- Organizer
  Gordon Research Conferences
- Place of Presentation
  New London, USA
- Data Source
  KAKENHI-PROJECT-18590276
[Presentation] Substrate Binding Mode of Mammalian XOR; Implications for Hydroxylation Mechanism.2007
- Author(s)
  Ken Okamoto
- Organizer
  Gordon research conference
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-18590276
[Presentation] Potent inhibitors of xanthine oxidoreductase : Mechansims of inhibition and crystal structures of the enzyme-inhibitor complexes2007
- Author(s)
  Ken Okamoto
- Organizer
  12th International Symposium on Purine and Pyrimidine Metabolism in Man
- Place of Presentation
  U.S.A
- Year and Date
  2007-06-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] Ligand Binding Structures of Mammalian Xanthine Oxidoreductase : Implications for Hydroxylation Mechanism2007
- Author(s)
  Ken Okamoto
- Organizer
  Gordon Research Conferences(Molybdenum & Tungsten Enzymes)
- Place of Presentation
  U.S.A
- Year and Date
  2007-07-01
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] Ligand Binding Structures of Mammalian Xanthine Oxidoreductase: Implications for Hydroxylation Mechanism.2007
- Author(s)
  Ken Okamoto
- Organizer
  Gordon Research Conferences(Molybdenum & Tungsten Enzymes)
- Place of Presentation
  アメリカニューロンドン
- Year and Date
  2007-07-01
- Data Source
  KAKENHI-PROJECT-16205021
[Presentation] The loop opening motion of the bacterial XOR with the inhibitor BOF: molecular dynamics study
- Author(s)
  H. Kikuchi, H. Fujisaki, T. Furuta, K. Okamoto, T. Nishino
- Organizer
  10th Congress of the World Association of Theoretical and Computational Chemists
- Place of Presentation
  Santiago, Chile
- Year and Date
  2014-10-05 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-26440081
[Presentation] The gate opening motion of xanthine binding pocket of XOR
- Author(s)
  K. Okamoto, H. Kikuchi, H. Fujisaki, T. Furuta, S. Leimkühler, T. Nishino
- Organizer
  International simposium of Flavins and Flavoproteins
- Place of Presentation
  Phechaburi, Thailand
- Year and Date
  2014-07-27 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-26440081

1. NISHINO Takeshi (40094312)

# of Collaborated Projects: 10 results

# of Collaborated Products: 39 results
2. IWASAKI Toshio (40277497)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
3. NISHINO Tomoko (80075613)

# of Collaborated Projects: 5 results

# of Collaborated Products: 31 results
4. MATSUMURA Tomohiro (20297930)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
5. KIKUCHI Hiroto (00224907)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
6. KUSANO Teruo (30434129)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
7. FUJISAKI Hiroshi (60573243)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
8. FURUTA Tadaomi (10431834)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
9. ABE Yasuko (60089612)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 堀弘幸 (20256960)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 永原則之 (10208043)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 石浜明 (80019869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 斎藤正男 (70302239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 石森浩一郎 (20192487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 新井賢一 (00012782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 三浦謹一郎 (30000227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 京極好正 (90012632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 田之倉優 (60136786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. PAI Emil F.

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
20. 加藤信介

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

OKAMOTO Ken 岡本 研

岡本 研 オカモト ケン

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Systemic and long term analysys of O2- hyperproduction micePrincipal Investigator

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Phasogenesis study of XOR mutant knock-in mouse.Principal Investigator

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Molecular basis of structure-based drug designPrincipal Investigator

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X線結晶構造解析及び、部位特異的変異法によるキサンチン脱水素酵素の構造・機能の研究Principal Investigator

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キサンチン酸化酵素における非ヘム鉄の機能に関する研究Principal Investigator

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OKAMOTO Ken 岡本研

岡本研オカモトケン