Souma Yoshirou 相馬義郎

… Alternative Names

SOHMA Yoshiro 相馬義郎

SOHMA YOSHIRO 有馬義郎

SOUMA Yoshirou 相馬義郎

相馬義郎ソウマヨシロウ

Less

Researcher Number	60268183
Other IDs
Affiliation (Current)	2025: 国際医療福祉大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2024: 国際医療福祉大学, 薬学部, 教授 2017 – 2022: 国際医療福祉大学, 薬学部, 教授 2016: 慶應義塾大学, 医学部(信濃町), 准教授 2016: 慶應義塾大学, 医学部(信濃町), 客員教授 2008 – 2016: Keio University, 医学部, 准教授 … More 2014: 慶応大学, 医学部, 准教授 2008 – 2009: 慶応義塾大学, 医学部, 准教授 2005 – 2007: Osaka Medical College, Faculty of Medicine, Assistant Professor, 医学部, 講師 2005: 名古屋大学, 医学部, 講師 2003 – 2004: 大阪医科大学, 医学部, 助手 2001: Osaka Medical College, Faculty of Medicine Research Assistant, 医学部, 助手 1999 – 2000: 大阪医科大学, 医学部・生理学, 助手 1995: 大阪医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator General physiology / Basic Section 48020:Physiology-related / Complex systems / General physiology Except Principal Investigator Embryonic/Neonatal medicine / Anesthesiology/Resuscitation studies / General physiology / Basic Section 56030:Urology-related / Basic Section 53010:Gastroenterology-related / Gastroenterology … More / Anesthesiology / Urology / Legal medicine / Ophthalmology / Orthopaedic surgery / Biological Sciences Less
Keywords	Principal Investigator CFTR / 分子間相互作用 / ゲーティング / ATP加水分解 / 抗原ー抗体反応 / 膜蛋白複合体 / １分子直接観察 / 高速原子間力顕微鏡 / チャネル / ABCトランスポータ … More / アクアポリン / ラフト / 脂質２重膜 / bicarbonate secretion / NBDドメイン / 水和 / 結合エネルギー / ATP結合ドメイン / 生体膜 / Nucleotide Binding Domain / 嚢胞線維症 / １分子観察 / 1分子観察 / 自己組織化 / 脂質ラフト / cholesterol / pancreatic duct cell / hydrophobic compound / gating / anion / ion channel / pancreatic duct / 重炭酸イオン / 外分泌 / 膵臓 / コレステロール / 重炭酸分泌 / 膵導管細胞 / 脂溶性物質 / 陰イオン / イオンチャネル / ABCトランスポーター / 抗原抗体反応 / 原子間力顕微鏡 / 抗原－抗体反応 / 膜輸送 / ABCトランスポ－タ－ / 能動輸送 / トランスポーター / ゲーテイング / ATP 加水分解 / Nucleotide Bindin Domain / 二量体化 / アニオン / 輸精管 / patch-clamp / K^+ channel / 上皮膜輸送 … More Except Principal Investigator GABA / CFTR / 三叉神経節 / GABA受容体 / satellite cell / サーファクタント / CARS顕微鏡 / パッチクランプ / 嚢胞性線維症 / SLC26A6 / 膵導管細胞 / GABA receptor / ASEM / 脂質 / グリア細胞 / KCTD16 / KCTD12 / real time PCR / ラット / 知覚神経節 / GABAB受容体 / βカリオフィレン / 前立腺癌 / 気管支 / 膵管 / iPS細胞 / 胆管上皮細胞 / 胆管 / CFTRバリアント / 肺胞Ⅱ型上皮 / ASEM顕微鏡 / プライマリカルチャー / 内科 / 生理学 / 細胞・組織 / 遺伝子 / オルガノイド / 腸管オルガノイド / VGLUT / サテライト細胞 / サテライト細胞（ＳＣ） / 三叉神経節（ＴＧ） / NMDAR / AMPA / グルタミン酸 / spermatogenesis / GABAergic system / 蛍光免疫染色 / RT-PCR / 免疫電顕 / 精子形成過程 / 精子発生過程 / GABAシステム / transgenic mice / sweat CI concentration / Cl-HCO_3^- exchange / HCO_3^-conductance / HCO_3^-transport / pancreatic duct cell / 慢性膵炎 / アルコール / モルモット単離小葉間膵管 / 管腔膜 / cut-off effect / 短鎖アルコール / 単離小葉間膵管 / cystic fibrosis / Na^+-H^+ exchange / Cl^--HCO_3^- exchange / 遺伝子変異マウス / 汗中Cl^-濃度 / Cl^--HCO_3^-交換 / HCO_3^-コンダクタンス / HCO_3^-輸送 / long QT syndrome / mutation / cardiac ion channel / sudden death / 遺伝子変異 / スプライス異常 / イオンチャンネル / 心臓性突然死 / QT延長症候群 / 変異 / 心臓イオンチャンネル / 突然死 / ドライアイ / 上皮細胞 / 再生 / 細胞株 / 涙腺 / trigeminal ganglion / GABAB / GABAB2 / GABAB1 / KCTD / 三叉神経痛 / 慢性肺疾患 / 肺胞上皮II型細胞 / 非線形光学顕微鏡 / 脂質分泌 / 肺胞II型上皮細胞 / exocytosis / Na channel / Ca2+イメージング / baclofen / 膜電位 / release / 神経伝達物質 / HCS2/8 / GABA B受容体 / Caチャネル / GAD / GABA_B受容体 / アポトーシス / OUMS-27 / 軟骨肉腫 / 低分子量G蛋白 / SLC26輸送体 / STASドメイン / 低分子量G蛋白質 / SLC26 / 膜輸送複合体 / 免疫染色 / パッチランプ / サブスタンスP / Baclofen / 片頭痛 / 疼痛 / marginal Cell / Ca2+ transport / Stria Vascularis / L-type Ca2+ channel / marginal cell / epithelium / Ca^<2+> transport / cochlea / endolymph / stria vascularis / TRP channel / L-type Ca^<2+> channel / 腎生理学 Less

β-カリオフィレンの前立腺癌骨転移に対する医療効果とその作用機序
- Principal Investigator
  
  早崎華
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kansai University of Welfare Sciences
Study for the mechanism of functional expression and dysfunction of membrane proteins through direct observations of single molecular fluctuationPrincipal Investigator
- Principal Investigator
  
  Sohma Yoshiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  International University of Health and Welfare
Study of cystic fibrosis using pancreatic ductal and biliary epithelia from human pluripotent stem cells
- Principal Investigator
  
  Ishiguro Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya University
A study to establish individualized medicine of cystic fibrosis using intestinal organoids derived from patients
- Principal Investigator
  
  Ishiguro Hiroshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya University
大気圧走査電子顕微鏡を用いた肺胞上皮におけるサーファクタント分泌機構の解明
- Principal Investigator
  
  松崎陽平
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Keio University
Study for functional mechanism of membrane protein complexes from the perspective of self-organization using single molecule direct observations.Principal Investigator
- Principal Investigator
  
  Sohma Yoshiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  International University of Health and Welfare
  Keio University
Crosstalk mechanism between glial cell- nerve cells with the GABA/ glutamic acid in the sensory ganglia
- Principal Investigator
  
  Hayasaki Hana
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Kansai University of Welfare Sciences
Development of technical basis for direct observations of membrane protein complex in dynamic equilibrium under a physiological conditionPrincipal Investigator
- Principal Investigator
  
  SOHMA Yoshiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Keio University
Study for mechanism of ABC transporters based on single molecular direct observations using high speed Atomic Force Microscopy.Principal Investigator
- Principal Investigator
  
  SOHMA Yoshiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Keio University
Surfactant-associated protein imaging in alveolar epithelialcells by Atmospheric Scanning Electron Microscope
- Principal Investigator
  
  MATSUZAKI Yohei
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Keio University
The study of the trigeminal neuralgia occurrence mechanism which an aberrant joining between cells in the ganglion causes
- Principal Investigator
  
  HAYASAKI HANA
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kansai University of Welfare Sciences
  Osaka Medical College
Establishment of lacrimal gland epithelial cell line for the evaluation of lacrimal gland cells
- Principal Investigator
  
  KAWAKITA TETSUYA
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Keio University
ＡＢＣトランスポータＮＢＤエンジンにおけるＡＴＰエネルギー利用メカニズムの解明Principal Investigator
- Principal Investigator
  
  相馬義郎
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Keio University
Coherent Anti-Stokes Raman Scattering (CARS) , non-linear optical microscope revealed the kinetics of lipid and water by direct observation.
- Principal Investigator
  
  IKEDA Kazushige
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Keio University
Study for ATP-driven transport mechanism of ABC transporters based on the "ATP hydrolysis switch" hypothesis.Principal Investigator
- Principal Investigator
  
  SOHMA Yoshiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Keio University
The approach to a trigeminal neuralgia mechanism based on a local GABA system hypothesis
- Principal Investigator
  
  HAYASAKI Hana
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Osaka Medical College
CFTR-SLC26輸送体複合体のイオン輸送機能における低分子量G蛋白質の役割
- Principal Investigator
  
  洪繁
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
New methods of differential diagnosis and treatment by GABA system in human cartilage tumors
- Principal Investigator
  
  KANBARA Kiyoto
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka Medical College
Mechanism of Nucleotide Binding Domain engine in ABC transportersPrincipal Investigator
- Principal Investigator
  
  SOHMA Yoshiro
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Keio University
  Osaka Medical College
Regulation of endocochlear potential -Role of Ca^<2+>-permeable channel in marginal cells of stria vascularis
- Principal Investigator
  
  KUBOTA Takahiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Osaka Medical College
Inhibitory effect of GABA in excitatory sensory ganglia
- Principal Investigator
  
  HAYASAKI Hana
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Osaka Medical College
The role of the GABAergic system during spermatogenesis
- Principal Investigator
  
  KANBARA Kiyoto
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Osaka Medical College
Physiological characteristics and molecular identity of HCO_3-conductance in pancreatic duct cells.
- Principal Investigator
  
  ISHIGURO HIROSHI
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Nagoya University
Effects of hydrophobic compounds on anion channels expressed in pancreatic duct cellsPrincipal Investigator
- Principal Investigator
  
  SOHMA Yoshiro
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Osaka Medical College
Mutation detection of cardiac ion channel genes in sudden death cases
- Principal Investigator
  
  SUZUKI Koichi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Legal medicine
- Research Institution
  Osaka Medical College
輸精管上皮細胞におけるイオン輸送の研究Principal Investigator
- Principal Investigator
  
  相馬義郎
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General physiology
- Research Institution
  Osaka Medical College

[Book] Cystic fibrosis and the CFTR anion channel. In: Handbook of Ion Channels2015
- Author(s)
  Sohma Y, Hwang TC
- Total Pages
  671
- Publisher
  CRC Press Taylor & Francis Books Inc
- Data Source
  KAKENHI-PROJECT-25293049
[Book] Curcumin : Biosynthesis, Medicinal Uses and Health Benefits(Eds Sasaki & Kichida)2012
- Author(s)
  Sohma Y, et al
- Publisher
  Nova Science Publishers(in press)
- Data Source
  KAKENHI-PROJECT-22590212
[Book] Curcumin: Biosynthesis, Medicinal Uses and Health Benefits2012
- Author(s)
  Sohma Y, Yu YC, Miki H, Nakamura Y, Hanyuda A, Lin HY, Yasui M, Bompadre SG, Hwang TC.
- Total Pages
  12
- Publisher
  Nova Science Publishers, New York, USA
- Data Source
  KAKENHI-PROJECT-22590212
[Book] Pharmaceutical implications of curcumin in the development of drugs for CF pharmacotherapy: combined effects with genistein In: Curcumin: Biosynthesis, Medicinal Uses and Health Benefits2012
- Author(s)
  Sohma Y, Yu YC, Miki H, Nakamura Y, Hanyuda A, Lin HY, Yasui M, Bompadre SGand Hwang TC
- Publisher
  Editors Sasaki J & KichidaM, Nova Science Publishers, Hauppauge, New York, USA.
- Data Source
  KAKENHI-PROJECT-22590212
[Book] Curcumin: Biosynthesis, Medicinal Uses and Health Benefits. Eds. Sasaki & Kichida2012
- Author(s)
  Sohma Y, Yu YC, Miki H, Nakamura Y, Hanyuda A, Lin HY, Yasui M, Bompadre SG, Hwang TC
- Total Pages
  12
- Publisher
  Nova Science Publishers, New York, USA
- Data Source
  KAKENHI-PUBLICLY-23118714
[Book] Application of high-resolution single-channel recording to functional studies of cystic fibrosis mutants. In: Cystic Fibrosis Protocols and Diagnosis, Methods in Molecular Biology, 7412011
- Author(s)
  Cai Z, Sohma Y, Bompadre SG, Sheppard DN and Hwang TC、Editors Amaral MD & Kunzelmann K
- Publisher
  Humana Press, Totowa, New Jersey, USA
- Data Source
  KAKENHI-PROJECT-22590212
[Book] Cystic Fibrosis Protocols and Diagnosis, Methods in Molecular Biology, 7412011
- Author(s)
  Cai Z, Sohma Y, Bompadre SG, Sheppard DN, Hwang TC
- Total Pages
  35
- Publisher
  Humana Press, New York, USA
- Data Source
  KAKENHI-PUBLICLY-23118714
[Journal Article] 尿細管のイオン輸送調節におけるCFTRの役割2021
- Author(s)
  相馬義郎、君島莉央、相馬光流
- Journal Title
  
  腎と透析
  
  Volume: 90巻5号 Pages: 649-653
- Data Source
  KAKENHI-PROJECT-20K07279
[Journal Article] 難病研究の進歩　嚢胞性線維症2020
- Author(s)
  石黒　洋、相馬義郎、山本明子
- Journal Title
  
  生体の科学
  
  Volume: 71 Pages: 436-437
- Data Source
  KAKENHI-PROJECT-20K08285
[Journal Article] Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-7702019
- Author(s)
  Yeh Han-I、Qiu Liming、Sohma Yoshiro、Conrath Katja、Zou Xiaoqin、Hwang Tzyh-Chang
- Journal Title
  
  Journal of General Physiology
  
  Volume: 151 Issue: 7 Pages: 912-928
- DOI
  10.1085/jgp.201912360
- Data Source
  KAKENHI-PROJECT-16H05122
[Journal Article] Characterization of Δ(G970-T1122)-CFTR, the most frequent CFTR mutant identified in Japanese cystic fibrosis patients2018
- Author(s)
  Wakabayashi-Nakao Kanako、Yu Yingchun、Nakakuki Miyuki、Hwang Tzyh-Chang、Ishiguro Hiroshi、Sohma Yoshiro
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 69 Issue: 1 Pages: 103-112
- DOI
  10.1007/s12576-018-0626-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J40033, KAKENHI-PROJECT-16K09392, KAKENHI-PROJECT-16K09393, KAKENHI-PROJECT-16H05122
[Journal Article] Molecular dynamics simulation study on the structural instability of the most common cystic fibrosis-associated mutant ΔF508-CFTR2018
- Author(s)
  Mitsuhiko Odera, Tadaomi Furuta, Yoshiro Sohma, Minoru Sakurai
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 15 Issue: 0 Pages: 33-44
- DOI
  10.2142/biophysico.15.0_33
- NAID
  130006337976
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K00400, KAKENHI-PUBLICLY-16H00825, KAKENHI-PROJECT-16H05122
[Journal Article] Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium.2017
- Author(s)
  Yamaguchi M, Steward MC, Smallbone K, Sohma Y, Yamamoto A, Ko SBH, Kondo T, Ishiguro H
- Journal Title
  
  Journal of Physiology
  
  Volume: 595 Issue: 6 Pages: 1947-1972
- DOI
  10.1113/jp273306
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293049, KAKENHI-PROJECT-15K15035, KAKENHI-PROJECT-16K09392
[Journal Article] Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate.2016
- Author(s)
  Lin WY, Sohma Y, Hwang TC
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 90 Issue: 3 Pages: 275-285
- DOI
  10.1124/mol.116.104570
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293049, KAKENHI-PROJECT-15K15035, KAKENHI-PROJECT-16H05122
[Journal Article] On the mechanism of gating defects caused by the R117H mutation in CFTR.2016
- Author(s)
  Yu YC, Sohma Y, Hwang TC
- Journal Title
  
  The Journal of Physiology
  
  Volume: 000.0 Issue: 12 Pages: 1-18
- DOI
  10.1113/jp271723
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15035, KAKENHI-PROJECT-25293049, KAKENHI-PROJECT-16H05122
[Journal Article] Expression and localization of aquaporin-4 in sensory ganglia2014
- Author(s)
  J Kato, Y Takai, M K Hayashi, Y Kato, M Tanaka, Y Soma, Y Abe, M Yasui
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 451 Issue: 4 Pages: 562-567
- DOI
  10.1016/j.bbrc.2014.08.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792152, KAKENHI-PROJECT-25293049
[Journal Article] Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR2014
- Author(s)
  Guo JH, Chen H, Ruan YC, Zhang XL, Zhang XH, Fok KL, Tsang LL, Yu MK, Huang WQ, Sun X, Chung YW, Jiang X, Sohma Y, Chan HC
- Journal Title
  
  Nature Communications
  
  Volume: 5 Issue: 1 Pages: 4420-4420
- DOI
  10.1038/ncomms5420
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293049
[Journal Article] Water-meditated forces between the nucleotide binding domains generate the power stroke in an ABC transporter2014
- Author(s)
  Furukawa-Hagiya T, Yoshida N, Chiba S, Hayashi T, Furuta T, Sohma Y, Sakurai M
- Journal Title
  
  Chemical Physics Letters
  
  Volume: 616 - 617 Pages: 165-170
- DOI
  10.1016/j.cplett.2014.10.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293049, KAKENHI-PROJECT-25410021, KAKENHI-PUBLICLY-26104511, KAKENHI-PUBLICLY-26104526
[Journal Article] チャネル1分子を動画で見たい。ABCトランスポーター CFTRチャネルのATP駆動性ゲーティング：静止画から動画へ2013
- Author(s)
  相馬義郎、山下隼人
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 141 Pages: 230-234
- NAID
  10031171122
- Data Source
  KAKENHI-PUBLICLY-23118714
[Journal Article] 特集　チャネル1分子を動画で見たい。　ABCトランスポーター CFTチャネルのATP駆動性ゲーティング：静止画から動画へ2013
- Author(s)
  相馬義郎、山下隼人
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 141 Pages: 230-234
- Data Source
  KAKENHI-PROJECT-25293049
[Journal Article] Mechanisms underlying regional differences in the Ca2+ sensitivity of BKCa current in arteriolar smooth muscle.2013
- Author(s)
  Yang Y, Sohma Y, Nourian Z, Ella SR, Li M, Stupica A, Korthuis RJ, Davis MJ, Braun AP, Hill M
- Journal Title
  
  Journal of Physiology
  
  Volume: 591 Issue: 5 Pages: 1277-1293
- DOI
  10.1113/jphysiol.2012.241562
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23118714, KAKENHI-PROJECT-25293049
[Journal Article] The Power Stroke Driven by ATP Binding in CFTR As Studied by by ATP Binding in CFTR As Studied by Molecular Dynamics Simulations2013
- Author(s)
  T. Furukawa-Hagiya
- Journal Title
  
  J. Phys. Chem. B
  
  Volume: 117 Issue: 1 Pages: 83-93
- DOI
  10.1021/jp308315w
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20118001, KAKENHI-PLANNED-20118006, KAKENHI-PROJECT-22590212, KAKENHI-PUBLICLY-23118714, KAKENHI-PROJECT-23570198
[Journal Article] Curcumin and Genistein: the combined effects on disease-associated CFTR mutants and their clinical implications.2013
- Author(s)
  Sohma Y, Yu YC, Hwang TC
- Journal Title
  
  Current Pharmaceutical Design
  
  Volume: 19 Issue: 19 Pages: 3521-3528
- DOI
  10.2174/13816128113199990320
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23118714, KAKENHI-PROJECT-25293049
[Journal Article] Amiodarone inhibits apamin-sensitive potassium currents2013
- Author(s)
  Turker I, Yu CC, Chang PC, Chen Z, Sohma Y, Lin SF, Chen PS, Ai T
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 7 Pages: e70450-e70450
- DOI
  10.1371/journal.pone.0070450
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23118714, KAKENHI-PROJECT-25293049
[Journal Article] Heterogenous GABA(B) receptor-mediated pathways are involved in the local GABAergic system of the rat trigeminal ganglion: possible involvement of KCTD proteins.2012
- Author(s)
  Hayasaki H, Sohma Y, Kanbara K, Otsuki Y.
- Journal Title
  
  Neuroscience.
  
  Volume: 218 Pages: 344-358
- DOI
  10.1016/j.neuroscience.2012.05.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592319
[Journal Article] Non-integral stoichiometry in CFTR gating revealed by a pore-lining mutation2012
- Author(s)
  Jih KY, Sohma Y, Hwang TC
- Journal Title
  
  J. Gen. Physiol
  
  Volume: 140 Issue: 4 Pages: 347-359
- DOI
  10.1085/jgp.201210834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590212, KAKENHI-PUBLICLY-23118714
[Journal Article] CFTRチャネルのATP依存性ゲーティング機構と活性増強薬の作用機序2012
- Author(s)
  相馬　義郎、松崎　陽平 et al
- Journal Title
  
  分子呼吸器病
  
  Volume: 16 Pages: 130-134
- Data Source
  KAKENHI-PROJECT-23591600
[Journal Article] Identification of a novel post-hydrolytic state in CFTR gating2012
- Author(s)
  Jih KY, Sohma Y, Li M, Hwang TC
- Journal Title
  
  J. Gen. Physiol.
  
  Volume: 139 Issue: 5 Pages: 359-370
- DOI
  10.1085/jgp.201210789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590212, KAKENHI-PUBLICLY-23118714
[Journal Article] Curcumin and Genistein Additively Potentiate G551D-CFTR2011
- Author(s)
  Yu YC, Miki H, Sohma Y, et al
- Journal Title
  
  Journal of Cystic Fibrosis
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590212
[Journal Article] Curcumin and genistein additively potentiate G551D-CFTR2011
- Author(s)
  Yu YC, Miki H, Nakamura Y, Hanyuda A, Matsuzaki Y, Abe Y, Yasui M, Tanaka K, Hwang TC, Bompadre SB, Sohma Y
- Journal Title
  
  J. Cystic Fibrosis
  
  Volume: 10 Pages: 243-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591990
[Journal Article] Curcumin and genistein additively potentiate G551D-CFTR.2011
- Author(s)
  Yu YC, Miki H, Nakamura Y, Hanyuda A, Matsuzaki Y, Abe Y, Yasui M, Tanaka K, Hwang TC, Bompadre SB, Sohma Y.
- Journal Title
  
  J. Cystic Fibrosis
  
  Volume: 10 Issue: 4 Pages: 243-252
- DOI
  10.1016/j.jcf.2011.03.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590212
[Journal Article] A stable ATP binding to nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR2010
- Author(s)
  Shimizu H, Yu YC, Kono K, Kubota T, Yasui M, Li M, Hwang TC, Sohma Y
- Journal Title
  
  J. Physiol. Sci
  
  Volume: 60 Pages: 353-362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591990
[Journal Article] A stable ATP binding to nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR2010
- Author(s)
  Shimizu H, Yu YC, Kono K, Kubota T, Yasui M, Li M, Hwang TC, Sohma Y
- Journal Title
  
  J. Physiol. Sci
  
  Volume: 60 Issue: 5 Pages: 353-362
- DOI
  10.1007/s12576-010-0102-2
- NAID
  10027504627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590212
[Journal Article] On the mechanism of CFTR inhibition by a thiazolidinone derivative.2010
- Author(s)
  Kopeikin Z, Sohma Y, Li M, Hwang TC
- Journal Title
  
  Journal of General Physiology
  
  Volume: 136 Pages: 659-671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590212
[Journal Article] A stable ATP binding to nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR2010
- Author(s)
  Shimizu H, Yu YC, Sohma Y, et al
- Journal Title
  
  Journal of Physiological Sciences
  
  Volume: 60 Pages: 353-362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590212
[Journal Article] On the mechanism of CFTR inhibition by a thiazolidinone derivative.2010
- Author(s)
  Kopeikin Z, Sohma Y, Li M, Hwang TC
- Journal Title
  
  J. Gen. Physiol.
  
  Volume: 136 Issue: 6 Pages: 659-671
- DOI
  10.1085/jgp.201010518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590212
[Journal Article] State-dependent modulation of CFTR gating by pyrophosphate.2009
- Author(s)
  Tsai MF, Shimizu H, Sohma Y, Li M Hwang TC
- Journal Title
  
  Journal of General Physiology 133
  
  Pages: 405-419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590215
[Journal Article] State-dependent modulation of CFTR gating by pyrophosphate.2009
- Author(s)
  Tsai MF, Shimizu H, Sohma Y, Li M, Hwang TC
- Journal Title
  
  J. Gen. Physiol. 133
  
  Pages: 405-419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590215
[Journal Article] Potentiation of BK channels by α5β1 integrin activation in arteriolar smooth muscle.2008
- Author(s)
  Wu X, Yang Y, Gui P, Sohma Y, Meininger GA, Davis GE, Braun AP, Davis MJ
- Journal Title
  
  J Physiol 586(6)
  
  Pages: 1699-1713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590215
[Journal Article] Constitutive activity of inwardly rectifying K^+ channel at physiological [Ca]_i is mediated byCa^<2+>/CaMK II pathway in opossum kidney proximal tubule cells2008
- Author(s)
  Mori Y, Yoshida H, Miyamoto M, Sohma Y and Kubota T.
- Journal Title
  
  J Physiol Sci 58
  
  Pages: 199-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590216
[Journal Article] Constitutive activity of inwardly rectifying K+ channel at physiological [Ca]I is mediated by Ca2+/CaMK II pathway in opossum kidney proximal tubule cells2008
- Author(s)
  Mori, Y., Yoshida, H., Miyamoto, M., Sohma, Y. and Kubota, T.
- Journal Title
  
  J. Physiol. Sci. 58
  
  Pages: 199-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591824
[Journal Article] Three-dimensional reconstruction of human cystic fibrosis trans membrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transme mbrane domain.2008
- Author(s)
  Mio K, Ogura T, Mio M, Shimizu H, Hwang TC, Sato C, Sohma Y
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 30300-30310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590215
[Journal Article] Potentiation of BK channels by α5β1 integrin activation in arteriolar smooth muscle2008
- Author(s)
  Wu X, Yang Y, Gui P, Sohma Y, et. al.
- Journal Title
  
  Journal of Physiology 586
  
  Pages: 1699-1713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590215
[Journal Article] Threedimensional reconstruction of human cystic fibrosis transmembrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domain.2008
- Author(s)
  Mio K, Ogura T, Mio M, Shimizu H, Hwang TC, Sato C, Sohma Y
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 30300-30310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590215
[Journal Article] Physiological role of L-type Ca^<2+> channels in marginal cells in the stria vascularis of guineapigs2007
- Author(s)
  Inui T, Mori Y, Watanabe M, Takamaki A, Yamaji J, Sohma Y, Yoshida R, Takenaka H and Kubota T.
- Journal Title
  
  J Physiol Sci 57
  
  Pages: 287-298
- NAID
  10022597080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590216
[Journal Article] G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects2007
- Author(s)
  Bompadre, S. G., Sohma, Y., Li, M. and Hwang, T.C.
- Journal Title
  
  J. Gen. Physiol 129
  
  Pages: 285-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591824
[Journal Article] A local GABAergic system within rat trigeminal ganglion cells.2006
- Author(s)
  Hayasaki H, Sohma Y, Kanbara K, Maemura K, et al.
- Journal Title
  
  European Journal of Neuroscience 23・3
  
  Pages: 745-757
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] A local GABAergic system within rat trigeminal ganglion cells.2006
- Author(s)
  Hayasaki H, Sohma Y, Kanbara K, Maemura K, Kubota T, Watanabe M
- Journal Title
  
  European Journal of Neuroscience 23
  
  Pages: 745-757
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] A local GABAergic system within rat trigeminal ganglion cells.2006
- Author(s)
  Hayasaki H, Sohma Y, Kanbara K, Maemura et al.
- Journal Title
  
  European Journal of Neuroscience 23・3
  
  Pages: 745-757
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] High affinity ATP/ADP analogues as new tools for studying CFTR gating.2005
- Author(s)
  Zhou Z, Wang X, Li M, Sohma Y, et al.
- Journal Title
  
  Journal of Physiology 569・2
  
  Pages: 447-457
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] CFTR gating I : Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR construct (ΔR-CFTR)2005
- Author(s)
  Bompadre SG, Ai T, Cho JH, Wang X, Sohma Y, et al.
- Journal Title
  
  Journal of General Physiology 125・4
  
  Pages: 361-375
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] CFTR gating I : Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR construct (ΔR-CFTR).2005
- Author(s)
  Bompadre SG, Ai T, Cho JH, Wang X, Sohma Y, Li M, Hwang TC
- Journal Title
  
  Journal of General Physiology 125
  
  Pages: 361-375
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] CFTR gating I : Characterization of the ATP-dependent gating of a phosphorylation-independent CETR construct (ΔR-CFTR)2005
- Author(s)
  Bompadre SG, Ai T, Cho JH, Wana X.Sohma T, et al.
- Journal Title
  
  Journal of General Physiology (印刷中)
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] Intracellular Mg^<2+> influences both open and closed times of a native Ca^<2+>-activated BK channel in cultured human renal proximal tubule cells.2005
- Author(s)
  Sohma Y, Kubokawa M, Hirano J, Nakamura K, Kubota T
- Journal Title
  
  Journal of Membrane Biology 207
  
  Pages: 69-89
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] CFTR gating II : Effects of nucleotide binding on the stability of open states.2005
- Author(s)
  Bompadre SG, Cho JH, Wang X, Zou X, Sohma Y, Li M, Hwang TC
- Journal Title
  
  Journal of General Physiology 125
  
  Pages: 377-394
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] CFTR gating I : Characterization of theATP-dependent gating of a phosphorylation-independent CFTR construct (ΔR-CFTR)2005
- Author(s)
  Bompadre SG, Ai T, Cho JH, Wang X, Sohma Y, et al.
- Journal Title
  
  Journal of General Physiology 125・4
  
  Pages: 361-375
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] CETR gating II : Effects of nucleotide binding on the stability of open states.2005
- Author(s)
  Bompadre SG, Cho JH, Wang X, Zou X, Sohma Y et al.
- Journal Title
  
  Journal of General physiology (印刷中)
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] CFTR gating II : Effects of nucleotide binding on the stability of open states.2005
- Author(s)
  Bompadre SG, Cho JH, Wang X, Zou X, Sohma Y, et al.
- Journal Title
  
  Journal of General Physiology 125・4
  
  Pages: 377-394
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] Intracellular Mg^<2+> influences both open and closed times of a native Ca(^<2+>)-activated BK channel in cultured human renal proximal tubule cells.2005
- Author(s)
  Sohma Y, Kubokawa M, Hirano J, Nakamura K, Kubota T
- Journal Title
  
  Journal of Membrane Biology 207・2
  
  Pages: 69-89
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] Intracellular Mg^<2+> influences both open and closed times of a native Ca^<(2+)->activated BK channel in cultured human renal proximal tubule cells.2005
- Author(s)
  Sohma Y, Kubokawa M, Hirano J, Nakamura K, Kubota T.
- Journal Title
  
  Journal of Membrane Biology 207・2
  
  Pages: 69-89
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] High affinity ATP/ADP analogues as new tools to study CFTR gating.2005
- Author(s)
  Zhou Z, Wang X, Li M, Sohma Y, Zou X, Hwang TC
- Journal Title
  
  Journal of Physiology 569
  
  Pages: 447-457
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] The patch-clamp and planar lipid bilayer techniques : powerful and versatile tools to investigate the CFTR Cl^- channel2004
- Author(s)
  Sheppard DN Gray MA, Gong X, Sohma Y, et al.
- Journal Title
  
  Journal of Cystic Fibrosis Suppl.2
  
  Pages: 101-108
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] Direct effects of 9-anthracene compounds on cystic fibrosis transmembrane conductance regulator gating2004
- Author(s)
  Ai T, Bompadre SG, Sohma Y, Wang X, Li M, Hwang TC
- Journal Title
  
  Pflugers Archiv - European Journal of Physiology 449
  
  Pages: 88-95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] Direct effects of 9-anthracene compounds on cystic fibrosis transmembrane conductance regulator gating.2004
- Author(s)
  Ai T, Bompadre SG, Sohma Y, et al.
- Journal Title
  
  Pflugers Archiv - European Journal of Physiology 449
  
  Pages: 88-95
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] Diredt effects of 9-anthracene compounds on cystic fibrosis transmembrane conductance regulator gating2004
- Author(s)
  Ai T, Bompadre SG, Sohma Y, et al.
- Journal Title
  
  Pflugers Archiv 449
  
  Pages: 88-95
- Data Source
  KAKENHI-PROJECT-16590164
[Journal Article] Direct effects of 9-anthracene compounds on cystic fibrosis transmembrane conductance regulator gating2004
- Author(s)
  AI T, Bompadre SG, Sohma T et al.
- Journal Title
  
  Pflugers Archiv 449
  
  Pages: 88-95
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] The patch-clamp and planar lipid bilayer techniques : powerful and versatile tools to investigate the CFTR C1^- channel2004
- Author(s)
  Sheppard DN, Gray MA, Gong X, Sohma Y, et al.
- Journal Title
  
  Journal of Cystic Fibrosis Suppl.2(総説)
  
  Pages: 101-108
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Journal Article] The patch-clamp and planar lipid bilayer techniques : powerful and versatile tools to investigate the CFTR Cl^- channel.2004
- Author(s)
  Sheppard DN, Gray MA, Gong X, Sohma Y, Kogan I, Benos DJ, Scott-Ward TS, Chen JH, Li H, Cai Z, Gupta J, Li C, Ramjeesingh M, Berdiev BK, Ismailov II, Bear CE, Hwang TC, Linsdell P, Hug MJ
- Journal Title
  
  Journal of Cystic Fibrosis Suppl 2
  
  Pages: 101-108
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590196
[Presentation] 日本人型嚢胞線維症病因CFTR変異体に対する白人型変異体治療薬の効果とメカニズムについて2022
- Author(s)
  小川亜美、小川未裕、石塚柊太、大塚悠花、黒澤歩実、小林可奈、齋藤佑香、髙橋柚妃、植松咲貴、中島乃愛、君島莉央、相馬光流、中尾香菜子、相馬義郎
- Organizer
  生理研研究会2022 「上皮膜輸送と細胞極性形成機構の統合的理解を目指して」　岡崎市生理学研究所
- Data Source
  KAKENHI-PROJECT-20K07279
[Presentation] Therapeutic drugs developed for CFTR mutants found in Caucasian Cystic Fibrosis patients also succeeded to rescue CFTR mutants found in Japanese patients.2022
- Author(s)
  君島莉央、相馬光流、中川大、古田忠臣、石黒洋、中尾香菜子、相馬義郎
- Organizer
  日本生理学会第100回記念大会　国立京都国際会館
- Data Source
  KAKENHI-PROJECT-20K07279
[Presentation] Molecular dynamics simulation study on structural instability of CFTR mutants in Japanese CF patients and effects of CFTR correctors on them.2022
- Author(s)
  Hikaru Sohma, Rio Kimishima, Shuta Ishizuka, Kanako Wakabayashi-Nakao, Yoshiro Sohma
- Organizer
  第96回日本薬理学会年会 / 第43回日本臨床薬理学会学術総会　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20K07279
[Presentation] AbbVie 第Ⅱ相治験薬 Galicaftor の日本人型病因性CFTR変異体への効果2022
- Author(s)
  小川亜美、小川未裕、石塚柊太、大塚悠花、黒澤歩実、小林可奈、齋藤佑香、髙橋柚妃、植松咲貴、中島乃愛、君島莉央、相馬光流、中尾香菜子、中川大、古田忠臣、相馬義郎
- Organizer
  第8回嚢胞性線維症情報交換会　名古屋大学鶴友会館
- Data Source
  KAKENHI-PROJECT-20K07279
[Presentation] Effects of the therapeutic drugs for Cystic Fibrosis in Caucasians on CFTR mutations found in Japanese patients.2022
- Author(s)
  Rio Kimishima, Hikaru Sohma, Masahiro Shimizu, Shiori Ohkawa, Yuka Matsuzawa, Suzuna Kaneko, Yuki Fukada, Kanako Wakabayashi-Nakao, Yoshiro Sohma
- Organizer
  第96回日本薬理学会年会 / 第43回日本臨床薬理学会学術総会　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20K07279
[Presentation] 日本人H1085RおよびL441P-CFTR変異体に対するVertex発現増強薬の効果について2021
- Author(s)
  清水正浩、大川詩織、松澤由佳、金子すずな、深田侑希、直井佑太、成田和希、石塚柊太、小川亜美、小川未裕、大塚悠花、黒澤歩実、君島莉央、相馬光流、中尾香菜子、相馬義郎
- Organizer
  第7回嚢胞性線維症情報交換会
- Data Source
  KAKENHI-PROJECT-20K07279
[Presentation] 日本人型嚢胞線維症H1085R-およびL441P-CFTR変異体に対する白人型病因性CFTR変異体発現促進薬の効果2021
- Author(s)
  清水正浩、大川詩織、松澤由佳、金子すずな、深田侑希、直井佑太、成田和希、石塚柊太、小川亜美、小川未裕、大塚悠花、黒澤歩実、君島莉央、相馬光流、中尾香菜子、相馬義郎
- Organizer
  2021年度生理学研究所研究会「上皮膜輸送の多様性・調和機構を基盤とする異分野融合研究の創出」
- Data Source
  KAKENHI-PROJECT-20K07279
[Presentation] Functional rescue for the second and third most frequent disease-associated CFTR mutants in Japanese CF patients by the therapeutic drug for Caucasian mutants2021
- Author(s)
  Rio Kimishima, Hikaru Sohma, Masahiro Shimizu, Shiori Ohkawa, Yuka Matsuzawa, Suzuna Kaneko, Yuki Fukada, Kanako Wakabayashi- Nakao, Yoshiro Sohma
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K07279
[Presentation] 日本人CFTR変異体へのCFTR corrector Lumacaftor の効果について2020
- Author(s)
  君島莉央、相馬光流、岩井翔吾、松澤由佳、金子すずな、深田侑希、大川詩織、清水正浩、小林奈央、直井佑太、成田和希、相馬義郎
- Organizer
  第6回嚢胞性線維症情報交換会
- Data Source
  KAKENHI-PROJECT-20K07279
[Presentation] 日本人CFTR変異体への白人型CFTR変異治療薬の効果について2020
- Author(s)
  君島莉央、相馬光流、岩井翔吾、松澤由佳、金子すずな、深田侑希、大川詩織、清水正浩、小林奈央、直井佑太、成田和希、相馬義郎
- Organizer
  2020年度生理学研究所研究会「上皮膜輸送の多様性・調和機構を基盤とする異分野融合研究の創出」
- Data Source
  KAKENHI-PROJECT-20K07279
[Presentation] 日本人嚢胞線維症患者におけるCFTRチャネル変異体の機能不全2020
- Author(s)
  相馬義郎, 清水正浩, 大川詩織, 松澤由佳, 金子すずな, 深田侑希, 成田和希, 直井佑太, 君島莉央, 相馬光流, 岩井翔吾, 小林奈央, 中尾香菜子
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K07279
[Presentation] 日本人由来の CFTR 変異体の分子病態学的特性2019
- Author(s)
  相馬義郎、君島莉央、岩井翔梧、相馬光流、小林奈央、中尾香菜子
- Organizer
  第97回日本生理学会大会　大分・別府（誌上開催）
- Data Source
  KAKENHI-PROJECT-16H05122
[Presentation] Characterization of disease-associated CFTR-mutants found in Japanese cystic fibrosis patients2019
- Author(s)
  Wakabayashi-Nakao K, Yu Y, Nakakuki M, Hwang TC, Ishiguro H, Sohma Y
- Organizer
  42nd European Cystic Fibrosis Conference, Liverpool, UK
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05122
[Presentation] 日本人嚢胞線維症患者の分子病態生理学と治療学2019
- Author(s)
  相馬義郎
- Organizer
  生理研研究会「上皮膜・間質の機能連関と病態発現機構解明のためのストラテジー」　岡崎・愛知
- Data Source
  KAKENHI-PROJECT-16H05122
[Presentation] CHARACTERIZATION OF THE MOST FREQUENT CFTR-MUTANT FOUND IN JAPANESE CYSTIC FIBROSIS PATIENTS2019
- Author(s)
  Wakabayashi-Nakao K, Yu YC, Nakakuki M, Hwang TC, Ishiguro H, Sohma Y
- Organizer
  The 9th Federation of the Asian and Oceanian Physiological Societies Congress FAOPS 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05122
[Presentation] 日本人嚢胞線維症患者のCFTR 分子病態生理学2019
- Author(s)
  相馬義郎、君島莉央、相馬光流、小林奈央、岩井翔吾
- Organizer
  生理研研究会「イオンチャネルと生体膜のダイナミズム：構造生物学の先にあるもの」大阪
- Data Source
  KAKENHI-PROJECT-16H05122
[Presentation] CARS顕微鏡を用いた経上皮膜水拡散現象の研究2018
- Author(s)
  相馬義郎
- Organizer
  生理研研究会「体内環境の維持機構における上皮膜輸送の多角的・総合的理解」　岡崎・愛知
- Data Source
  KAKENHI-PROJECT-16H05122
[Presentation] Clinical characteristics, prognosis, and CFTR mutations of cystic fibrosis in Japan2018
- Author(s)
  Ishiguro H, Yamamoto A, Fujiki K, Nakakuki M, Taniguchi I, Kozawa Y, Sohma Y, Naruse S, Takeyama Y
- Organizer
  49th Annual Meeting of American Pancreatic Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09392
[Presentation] CHARACTERIZATION OF THE MOST FREQUENT CFTR-MUTANT FOUND IN JAPANESE CYSTIC FIBROSIS PATIENTS2018
- Author(s)
  Wakabayashi-Nakao K, Yu Y, Nakakuki M, Hwang TC, Ishiguro H, Sohma Y
- Organizer
  第9回アジア・オセアニア生理学会連合大会＆第96回日本生理学会合同大会　神戸・兵庫
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05122
[Presentation] CARS顕微鏡を用いた経上皮膜水拡散現象の研究2018
- Author(s)
  相馬義郎
- Organizer
  生理研研究会「体内環境の維持機構における上皮膜輸送の多角的・総合的理解」
- Data Source
  KAKENHI-PROJECT-16H05122
[Presentation] Characterization of frequent CFTR mutants in Japanese cystic fibrosis patients2018
- Author(s)
  Wakabayashi-Nakao K, Sohma Y
- Organizer
  第49回生理研国際シンポジウム　"Ion channels: looking back, seeing ahead"　岡崎・愛知
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05122
[Presentation] Characterization of a CFTR-mutant frequently found in Japanese cystic fibrosis patients.2017
- Author(s)
  Nakao K, Nakakuki M, Ishiguro H, Sohma Y
- Organizer
  14th Eeuropean Cystic Fibrosis Society Basic Science Conference
- Place of Presentation
  Algarve, Portugal
- Year and Date
  2017-03-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] 嚢胞性線維症日本人患者から同定された変異型CFTRの特性解析2017
- Author(s)
  中尾香菜子、石倉麗音奈、中莖みゆき、石黒洋、政池知子、相馬義郎
- Organizer
  第94回日本生理学会年会
- Place of Presentation
  アクトシティ浜松（静岡県浜松市）
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] Characterization of a CFTR-mutant frequently found in Japanese cystic fibrosis patients.2017
- Author(s)
  Nakao K, Nakakuki M, Ishiguro H, Sohma Y
- Organizer
  14th Eeuropean Cystic Fibrosis Society Basic Science Conference
- Place of Presentation
  Algarve, Portugal
- Year and Date
  2017-03-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15035
[Presentation] Characterization of a CFTR-mutant frequently found in Japanese cystic fibrosis patients2017
- Author(s)
  Nakao K, Nakakuki M, Ishiguro H, Sohma Y
- Organizer
  14th ECFS Basic Science Conference, Algarve, Portugal
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05122
[Presentation] 嚢胞性線維症日本人患者から同定された変異型CFTRの特性解析2017
- Author(s)
  中尾香菜子、石倉麗音奈、中莖みゆき、石黒洋、政池知子、相馬義郎
- Organizer
  第94回日本生理学会年会
- Place of Presentation
  アクトシティ浜松（静岡県浜松市）
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-15K15035
[Presentation] 嚢胞性線維症日本人患者から同定された変異型CFTRの特性解析2017
- Author(s)
  中尾香菜子，石倉麗音奈，中莖みゆき，石黒洋，政池知子，相馬義郎
- Organizer
  第94回日本生理学会年会，浜松
- Data Source
  KAKENHI-PROJECT-16H05122
[Presentation] 日本人嚢胞性線維症患者から同定されたCFTR変異体の解析2017
- Author(s)
  中尾香菜子、石倉麗音奈、中莖みゆき、安井正人、石黒洋、政池知子、相馬義郎
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] 日本人嚢胞性線維症患者から同定されたCFTR変異体の解析2017
- Author(s)
  中尾香菜子、石倉麗音奈、中莖みゆき、安井正人、石黒洋、政池知子、相馬義郎
- Organizer
  第90回日本薬理学会年会，長崎
- Data Source
  KAKENHI-PROJECT-16H05122
[Presentation] 日本人嚢胞性線維症患者から同定されたCFTR変異体の解析2017
- Author(s)
  中尾香菜子、石倉麗音奈、中莖みゆき、安井正人、石黒洋、政池知子、相馬義郎
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K15035
[Presentation] CFTR and AQP: Two channels deeply involved into incurable diseases2016
- Author(s)
  相馬義郎
- Organizer
  第93回日本生理学会年会シンポジウム
- Place of Presentation
  札幌コンベンションセンター、札幌
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15K15035
[Presentation] Channel function in normal and Asian-mutant CFTR2016
- Author(s)
  Sohma Y
- Organizer
  2016 International Conference of Physiological Sciences, The Logic of Life, Beijing, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05122
[Presentation] An immunocytochemical study for the local glutamatergic system in rat trigeminal ganglion.2016
- Author(s)
  H. Hayasaki, A. Fukuda, Y. Sohma
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-15K10565
[Presentation] CFTR and AQP: Two channels deeply involved into incurable diseases2016
- Author(s)
  相馬義郎
- Organizer
  第93回日本生理学会年会シンポジウム
- Place of Presentation
  札幌コンベンションセンター、札幌
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] Monitoring ATP-hydrolysis cycle by electro-physiological approach: Patch-clamp recordings of CFTR2015
- Author(s)
  相馬義郎
- Organizer
  第53回日本生物物理学会年会シンポジウム
- Place of Presentation
  金沢大学、金沢
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-15K15035
[Presentation] 高速原子間力顕微鏡を用いた水チャネル AQP4 への自己抗体の結合・解離動態の直接観察2015
- Author(s)
  相馬義郎、山下隼人
- Organizer
  平成27年度生理学研究所研究会「生体ホメオスタシスのgatewayとしての上皮膜輸送マイクロホメオスタシス
- Place of Presentation
  生理学研究所、岡崎
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] Two novel direct observations in membrane transports: transepithelial water diffusion and single channel molecules2015
- Author(s)
  Sohma Y
- Organizer
  Kitasato-Yale Fluid Symposium 2015
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2015-03-02
- Invited
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] 高速原子間力顕微鏡を用いた膜蛋白への抗体結合・解離動態の直接観察2015
- Author(s)
  相馬義郎、山下隼人
- Organizer
  平成27年度生理学研究所研究会「膜システムの機能的・構造的統合」
- Place of Presentation
  生理学研究所、岡崎
- Year and Date
  2015-09-01
- Data Source
  KAKENHI-PROJECT-15K15035
[Presentation] Monitoring ATP-hydrolysis cycle by electro-physiological approach: Patch-clamp recordings of CFTR2015
- Author(s)
  相馬義郎
- Organizer
  第53回日本生物物理学会年会シンポジウム
- Place of Presentation
  金沢大学、金沢
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] Two novel approaches to CFTR single molecular dynamics and water transport physiology: high-speed AFM and CARS microscopy2015
- Author(s)
  Sohma Y
- Organizer
  Seminar, Cystic Fibrosis Center, The University of North Carolina at Chapel Hill
- Place of Presentation
  Chapel Hill, NC, USA
- Year and Date
  2015-02-20
- Invited
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] Dynamic Bindings of Autoimmune IgG Antibodies against Autoantigen Membrane Proteins directly Observed by High-Speed Atomic Force Microscopy (HS-AFM)2015
- Author(s)
  Sohma Y
- Organizer
  The Second Kitasato-Yale Fluid Symposium: Molecular Control of Cellular and Epithelial Function
- Place of Presentation
  北里大学、白金、東京
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] 高速原子間力顕微鏡を用いた膜蛋白への抗体結合・解離動態の直接観察2015
- Author(s)
  相馬義郎、山下隼人
- Organizer
  平成27年度生理学研究所研究会「膜システムの機能的・構造的統合
- Place of Presentation
  生理学研究所、岡崎
- Year and Date
  2015-09-01
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] 高速原子間力顕微鏡を用いた水チャネル AQP4 への自己抗体の結合・解離動態の直接観察2015
- Author(s)
  相馬義郎、山下隼人
- Organizer
  平成27年度生理学研究所研究会「生体ホメオスタシスのgatewayとしての上皮膜輸送マイクロホメオスタシス
- Place of Presentation
  生理学研究所、岡崎
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-15K15035
[Presentation] Dynamic Bindings of Autoimmune IgG Antibodies against Autoantigen Membrane Proteins directly Observed by High-Speed Atomic Force Microscopy (HS-AFM)2015
- Author(s)
  Sohma Y
- Organizer
  TheSecond Kitasato-Yale Fluid Symposium: Molecular Control of Cellular and Epithelial Function
- Place of Presentation
  北里大学、白金、東京
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15035
[Presentation] CARS顕微鏡と高速原子間力顕微鏡：上皮膜輸送研究に有用な２つの革新的測定技術2014
- Author(s)
  相馬義郎、山下隼人、余　盈君、安井正人
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] Expression and interaction of GABAB receptors and KCTD proteins in rat trigeminal ganglion and spinal trigeminal nucleus caudalis2014
- Author(s)
  H. Hayasaki, Y. Otsuki, Y. Sohma
- Organizer
  第３７回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-24592319
[Presentation] 高速AFMによるCFTRチャネルのゆらぎの一分子動態観察2013
- Author(s)
  相馬義郎
- Organizer
  第90回日本生理学会年会　シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] CARS顕微鏡と高速原子間力顕微鏡：上皮膜輸送研究に有用な２つの革新的測定技術2013
- Author(s)
  相馬義郎、山下隼人、余　盈君、安井正人
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス
- Data Source
  KAKENHI-PUBLICLY-23118714
[Presentation] 高速AFMによるアクアポリン4チャネルの直接観察2013
- Author(s)
  山下隼人、会津心之亮、加藤純悟、阿部陽一郎、安井正人、相馬義郎
- Organizer
  第 51 回日本生物物理学会年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PUBLICLY-23118714
[Presentation] 高速AFMによる膜機能分子のゆらぎの直接観察2013
- Author(s)
  相馬義郎、山下隼人
- Organizer
  平成２５年度生理研研究会「膜機能分子の機能・構造ゆらぎの時空間スペクトル解析」
- Place of Presentation
  岡崎コンファレンスセンター、岡崎市、愛知県
- Data Source
  KAKENHI-PUBLICLY-23118714
[Presentation] 分子動力学シミュレーションで探るCFTRにおける変異の影響2013
- Author(s)
  小寺充彦、萩谷朋佳、古田忠臣、相馬義郎、櫻井実
- Organizer
  第 51 回日本生物物理学会年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] 高速AFMによるCFTRチャネルのゆらぎの一分子動態観察2013
- Author(s)
  相馬義郎
- Organizer
  第90回日本生理学会年会　シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PUBLICLY-23118714
[Presentation] ABC トランスポータCFTR チャネルのATP 駆動ゲーティング機構2013
- Author(s)
  相馬義郎
- Organizer
  第341 回情報計算化学生物学会研究講演会
- Place of Presentation
  東京大学山上会館大会議室
- Invited
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] 高速AFMによるCFTRチャネルのゆらぎの一分子動態観察2013
- Author(s)
  相馬義郎
- Organizer
  第90回日本生理学会年会シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] ABC トランスポータCFTR チャネルのATP 駆動ゲーティング機構2013
- Author(s)
  相馬義郎
- Organizer
  第341 回情報計算化学生物学会研究講演会
- Place of Presentation
  東京大学山上会館大会議室
- Invited
- Data Source
  KAKENHI-PUBLICLY-23118714
[Presentation] 高速AFMによるアクアポリン4チャネルの直接観察2013
- Author(s)
  山下隼人、会津心之亮、加藤純悟、阿部陽一郎、安井正人、相馬義郎
- Organizer
  第 51 回日本生物物理学会年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] 高速AFMによる膜機能分子のゆらぎの直接観察2013
- Author(s)
  相馬義郎、山下隼人
- Organizer
  平成２５年度生理研研究会「膜機能分子の機能・構造ゆらぎの時空間スペクトル解析」
- Place of Presentation
  岡崎コンファレンスセンター、岡崎市、愛知県
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] ラット三叉神経節におけるGABAB レセプター応答の不均一性におけるKCTD サブユニットの寄与2013
- Author(s)
  Hayasaki H, Sohma Y, Kanbara K, Otsuki Y.
- Organizer
  第118回日本解剖学会総会
- Place of Presentation
  サンポートホール高松（香川）
- Data Source
  KAKENHI-PROJECT-24592319
[Presentation] 分子動力学シミュレーションで探るCFTRにおける変異の影響2013
- Author(s)
  小寺充彦、萩谷朋佳、古田忠臣、相馬義郎、櫻井実
- Organizer
  第 51 回日本生物物理学会年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PUBLICLY-23118714
[Presentation] 高速AFMによるCFTRチャネルのゆらぎの一分子動態観察2013
- Author(s)
  相馬義郎
- Organizer
  第90回日本生理学会年会　シンポジウム
- Place of Presentation
  東京タワーホール船堀
- Data Source
  KAKENHI-PUBLICLY-23118714
[Presentation] Effects of genistein and curcumin on non-hydrolytic CFTR mutants2012
- Author(s)
  Nakamura Y, Hanyuda A, Yu YC, Hagiya-Furukawa T, Odera M, Hwang TC, Sakurai M, Yasui M, Sohma Y.
- Organizer
  56th Biophysical Society Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] 高速AFM によるCFTR チャネルの動態観察2012
- Author(s)
  山下隼人、三尾和弘、三尾宗代、内橋貴之、安井正人、安藤敏夫、相馬義郎
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋大学東山キャンパス
- Data Source
  KAKENHI-PUBLICLY-23118714
[Presentation] Heterogeneous GABAB function underlied by KCTD Proteins in Rat Trigeminal Ganglion2012
- Author(s)
  Hayasaki H, Sohma Y, Kanbara K, Otsuki Y.
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-24592319
[Presentation] 高速AFM によるCFTR チャネルの動態観察2012
- Author(s)
  Yamashita H, Mio K, Mio M, Uchihashi T, Yasui M, Ando T, Sohma Y
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] ABCトランスポータCFTRチャネルのATP駆動性ゲーティング:静止画から動画へ2012
- Author(s)
  相馬義郎
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都国際会議場(京都府)(シンポジウム)
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] GABA handling system in the rat trigeminal ganglion2012
- Author(s)
  早崎華, 森島寿貴, 相馬義郎, 吉田祥子, 福田敦夫, 大槻勝紀
- Organizer
  第117回日本解剖学会総会・全国学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21591990
[Presentation] ABCトランスポータCFTRチャネルのATP加水分解駆動性ゲーティングの構造機能連関2012
- Author(s)
  相馬義郎
- Organizer
  第89回日本生理学会年会シンポジウム
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] Effects of genistein and curcumin on non-hydrolytic CFTR mutants2012
- Author(s)
  Sohma Y
- Organizer
  56th Biophysical Society Annual Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PUBLICLY-23118714
[Presentation] 高速AFM によるCFTR チャネルの動態観察2012
- Author(s)
  山下隼人（相馬義郎）
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PUBLICLY-23118714
[Presentation] ABCトランスポータCFTRチャネルのATP加水分解駆動性ゲーティングの構造機能連関2012
- Author(s)
  相馬義郎
- Organizer
  第89回日本生理学会年会
- Place of Presentation
  松本文化会館(長野県)(シンポジウム)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] ABCトランスポータCFTRチャネルのATP加水分解駆動性ゲーティングの構造機能連関2012
- Author(s)
  相馬義郎
- Organizer
  第89回日本生理学会年会　シンポジウム
- Place of Presentation
  松本
- Data Source
  KAKENHI-PUBLICLY-23118714
[Presentation] ABCトランスポータCFTRチャネルのATP駆動性ゲーティング：静止画から動画へ2012
- Author(s)
  相馬義郎
- Organizer
  第85回日本薬理学会年会　シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PUBLICLY-23118714
[Presentation] ABCトランスポータCFTRチャネルのATP駆動性ゲーティング:静止画から動画へ2012
- Author(s)
  相馬義郎
- Organizer
  第85回日本薬理学会年会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] ABCトランスポータ・CFTRチャネルにおけるATP加水分解の成否を決めている作動サイクル中間状態2011
- Author(s)
  相馬義郎, 6人中6番目
- Organizer
  第49回日本生物物理学会年会
- Place of Presentation
  兵庫県立大学姫路書写キャンパス(兵庫県)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] A hidden open state for priming ATP-hydrolysis in an ABC transporter CFTR channel.2011
- Author(s)
  Yu YC, Furukawa-Hagiya T, Nakamura Y, Yasui M, Hwang TC, Sakurai M, Sohma Y.
- Organizer
  第88回日本生理学会年会
- Place of Presentation
  Journal of Physiological Sciences 誌上開催
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] ABCトランスポータ・CFTRチャネルにおけるATP加水分解の成否を決めている作動サイクル中間状態2011
- Author(s)
  相馬義郎
- Organizer
  第49回日本生物物理学会年会
- Place of Presentation
  姫路
- Data Source
  KAKENHI-PUBLICLY-23118714
[Presentation] ABCトランスポータ・CFTRチャネルにおけるATP加水分解の成否を決めている作動サイクル中間状態2011
- Author(s)
  余盈君, 古川(萩谷) 朋佳, 安井正人, Hwang TC, 櫻井実, 相馬義郎
- Organizer
  第49回日本生物物理学会年会
- Place of Presentation
  姫路
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] A hidden intermediate state for priming ATP-hydrolysis during open conformation in CFTR channels2011
- Author(s)
  Sohma Y, Yu YC, Yasui M, Hwang TC.
- Organizer
  55th Biophysical Society Annual Meeting
- Place of Presentation
  Baltimore, Maryland, USA
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] CFTRチャネルのATP依存性ゲーティング機構と活性増強薬の作用機序2011
- Author(s)
  相馬　義郎、松崎　陽平 et al
- Organizer
  肺サーファクタント分子病態研究会
- Place of Presentation
  札幌医科大学　記念ホール　（北海道）
- Data Source
  KAKENHI-PROJECT-23591600
[Presentation] A hidden open state for priming ATP-hydrolysis in an ABC transporter CFTR channel.2011
- Author(s)
  Yu YC, Furukawa-Hagiya T, Sohma Y, et al
- Organizer
  第88回日本生理学会年会
- Place of Presentation
  Journal of Physiological Sciences(誌上開催)
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] Effects of aromatic carboxylic acids on genistein-and curcumin-potentiated G551D-CFTR2010
- Author(s)
  Nakamura Y, Sohma Y, et al(10名中10番目)
- Organizer
  54^<th> Biophysical Society Annual Meeting
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] Functional Probing of an ABC Transpoter, Cystic Fibrosis Transmembraneconduc tance Regulator (CFTR) Channel by Small Aromatic Carboxylic Acids.2010
- Author(s)
  Sohma Y, Nakamura Y, Yu YC, Furukawa T, Matsuzaki Y, Abe Y, Yasui M
- Organizer
  83rd Annual Meeting of The Japanese Pharmacological Society
- Place of Presentation
  Osaka, Japan
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] Blocking kinetics of CFTR channel by aromatic carboxylic acid positional isomers characterised using a novel amplitude distribution analysis method2010
- Author(s)
  Yu YC, Sohma Y, et al(8名中5番目)
- Organizer
  54^<th> Biophysical Society Annual Meeting
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] 芳香族カルボン酸をプローブとして用いたABCトランスポータ・CFTRチャネルの構造機能解析2010
- Author(s)
  相馬義郎, 他(8名中1番目)
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪国際会議場(大阪)
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] olecular mechanism of a multi-functional Cl- channel CFTR. Symposium "Regulation of various physiological functions by chloridetransporting proteins"2010
- Author(s)
  Sohma Y
- Organizer
  87th Annual Meeting, The Physiological Society of Japan
- Place of Presentation
  Morioka, Japan
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] Two possible mechanisms underlying a halt of NBD gating engine induced by instability of ATP binding in an ABC transporter CFTR.2010
- Author(s)
  Yu YC, Sohma Y, Hwang TC, Yasui M.
- Organizer
  第48回日本生物物理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22590212
[Presentation] Two distinct gating cycles of CFTR chloride channels.2009
- Author(s)
  sai MF, Shimizu H, Sohma Y, Li M, Hwang TC.
- Organizer
  53th Biophysical Society Annual Meeting
- Place of Presentation
  Boston, Massachusetts, USA
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] 3D structure of humnan CFTR chloride channel revealed an ellipsoidal form with orifices beneath the putative transmembrane domain2009
- Author(s)
  相馬義郎, 他(7名中1番目)
- Organizer
  XXXVI International Congress of Physiological Sciences(IUPS2009)
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] Three dimensional reconstruction of CFTR chloride channel using single particle analysis.2009
- Author(s)
  Mio K, Ogura T, Mio M, Shimizu H, Hwang TC, Sato C, Sohma Y
- Organizer
  53^<th> Biophysical Society Annual Meeting
- Place of Presentation
  Boston, Massachusetts, USA
- Year and Date
  2009-03-03
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] Two different binding sites for small aromatic carboxylic acids in CFTR2009
- Author(s)
  Yu YC, Sohma Y, et al(7名中4番目)
- Organizer
  The 40th NIPS International Symposium PAT-CVR2009
- Place of Presentation
  Okazaki, Japan
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] 3D STRUCTURE OF HUMNAN CFTR CHLORIDE CHANNEL REVEALED AN ELLIPSOIDAL FORM WITH ORIFICES BENEATH THE PUTATIVE TRANSMEMBRANE DOMAIN.2009
- Author(s)
  Sohma Y, Mio K, Ogura T, Mio M, Shimizu H, Hwang TC, Sato C.
- Organizer
  XXXVI International Congress of Physiological Sciences (IUPS2009) Function of Life: Elements and Integration
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] Two distinct gating cycles of CFTR chloride channels.2009
- Author(s)
  Tsai MF, Shimizu H, Sohma Y, Li M, Hwang TC.
- Organizer
  53^<th> Biophysical Society Annual Meeting
- Place of Presentation
  Boston, Massachusetts, USA
- Year and Date
  2009-03-03
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] Three dimensional reconstruction of CFTR chloride channel using single particle analysis.2009
- Author(s)
  Mio K, Ogura T, Mio M, Shimizu H, Hwang TC, Sato C, Sohma Y
- Organizer
  53th Biophysical Society Annual Meeting
- Place of Presentation
  Boston, Massachusetts, USA
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] CFTRチャネルにおけるATP加水分解ゲーティングェンジンの動作機構2008
- Author(s)
  相馬義郎
- Organizer
  日本生物物理学会第46回年会(シンポジウム
- Place of Presentation
  福岡国際会議場 (福岡)
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] Kiss-and-run gating of CFTR chloride channels2008
- Author(s)
  Shimizu H, Sohma Y, Li M, Hwang TC
- Organizer
  Joint Meeting of the Biophysical Society 52th Annual Meeting & 16th International Biophysics Congress(IUPAB)
- Place of Presentation
  Long Beach,Califbrnia,USA
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] Department of Anatomy and Cell Biology, Division of Basic Medicine I^1, and Department of Physiology^2, Osaka Medical College Department of Physical Therapy, Human Health Science, Graduate School of Medicine, Kyoto University^3 Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University^42008
- Author(s)
  K. Kanbara^1, M. Watanabe^1, Y. Sohma^2, Y. Mori^2, S. Nomura^3, K. Furuta^4, Y. Otsuki^1
- Organizer
  The 113st annual meeting of Japanese association of anatomists
- Place of Presentation
  Oita
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591788
[Presentation] Missfiring mechanism in NBD gating engine of CFTR chloride channel2008
- Author(s)
  Shimizu H, Sohma Y, Li M, Kubota T, Kono K, Hwang TC
- Organizer
  85th Annual Meeting of Physiological Society of Japan
- Place of Presentation
  Shinjyuku,Tokyo,Japan
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] Effects of W401 mutations on the stability of the open state in CFTR gating2008
- Author(s)
  Tsai MF, Shimizu H, Sohma Y, Li M, Hwang TC
- Organizer
  Joint Meeting of the Biophysical Society 52th Annual Meeting & 16th International Biophysics Congress(IUPAB)
- Place of Presentation
  Long Beach,California,USA
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] Mechanism of ATP hydrolysisdriven NBD gating engine in CFTR channel. Symposium "Dynamic Picture of Ion Channel upon Gating"2008
- Author(s)
  Sohma Y
- Organizer
  46th Annual Meeting, The Biophysical Society of Japan
- Place of Presentation
  Fukuoka, Japan
- Data Source
  KAKENHI-PROJECT-19590215
[Presentation] Expression and function of CFTR mutants found in Japanese CF patients
- Author(s)
  Yu Y, Nakakuki M, Ishiguro H, Sohma Y
- Organizer
  International symposium“Cystic fibrosis in Asia from basics to clinics”
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2014-09-29 – 2014-09-30
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] Mechanism of ATP-dependent gating in CFTR channels
- Author(s)
  Sohma Y
- Organizer
  Australian Physiological Society Meeting 2014
- Place of Presentation
  Brisbane, Australia
- Year and Date
  2014-11-30 – 2014-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] Structure and fluctuation of single CFTR molecules observed by high-speed atomic force microscopy
- Author(s)
  Sohma Y
- Organizer
  International symposium“Cystic fibrosis in Asia from basics to clinics”
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2014-09-29 – 2014-09-30
- Invited
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] Expression, function and phenotype of CFTR mutants found in Japanese CF patients
- Author(s)
  Sohma Y, Yu Y, Nakakuki M, Ishiguro H
- Organizer
  The 92th Annual Meeting of The Physiological Society of Japan
- Place of Presentation
  Kobe, Japan
- Year and Date
  2015-03-21 – 2015-03-23
- Invited
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] Let’s “See” ATP-dependent gating of CFTR channels
- Author(s)
  Sohma Y
- Organizer
  The 45th NIPS International Symposium “Cutting-edge approaches towards the functioning mechanisms of membrane proteins”
- Place of Presentation
  Okazaki, Japan
- Year and Date
  2014-11-25 – 2014-11-28
- Invited
- Data Source
  KAKENHI-PROJECT-25293049
[Presentation] Studies on the mechanism of a chloride channel CFTR in comparison with ion pumps
- Author(s)
  Masaike T, Sohma Y
- Organizer
  The 52th Annual Meeting, The Biophysical Society of Japan
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-25293049

1. HAYASAKI Hana (90257866)

# of Collaborated Projects: 5 results

# of Collaborated Products: 6 results
2. ISHIGURO Hiroshi (90303651)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
3. SATO Chikara (00357146)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. YAMAMOTO AKIKO (60402385)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
5. FUKUDA Atsuo (50254272)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
6. YASUI Masato (90246637)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
7. KUBOTA Takahiro (10084906)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
8. WATANABE Masahito (70084902)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
9. KANBARA Kiyoto (40298758)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
10. SAKURAI Minoru (50162342)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. MATSUZAKI Yohei (60327583)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
12. UCHIHASHI Takayuki (30326300)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. SOHMIYA Koichi (20319544)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. MORI Yoshiaki (70268192)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. TAKENAKA Hiroshi (40137162)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
16. NISHIZAKA Takayuki (40359112)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. 洪繁 (90402578)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
18. YU Ying-Chun

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
19. HWANG Tzyh-Chang

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
20. YAMAMOTO Daisuke (50240106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. HAYASHI Mariko (30525811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. IKEDA Kazushige (00193194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KAWAKITA TETSUYA (50408308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SUZUKI Koichi (60171211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TAMURA Akiyoshi (50207239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. NISHIO Hajime (90253260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. UENO Yoshiro (30184956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. HISHIDA Shigeru (10068463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. SHINDO Masahiko (10244592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. TAKII Michiaki (40319538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. KONDO TAKAHARU (20135388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. NARUSE SATORU (50180550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. NOMURA Sakasi (60034188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
34. NAKAKUKI Miyuki (30578729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
35. 有村奈利子 (20420375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 後藤秀実 (10215501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 植田直樹 (70298751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 辻洋子 (20309149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 古田忠臣 (10431834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
40. 中川大 (40397039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
41. 岩本真幸 (40452122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 大崎寿久 (50533650)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 小川真一郎 (30419353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 由留木裕子 (40549763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 桑原宏子 (50243754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. 濱岡仁美 (80545608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. RYU In

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. IKEURA Kazuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. YAMASHITA Hayato

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
50. KATO Takanobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. FUJIMURA Shoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. HWANG T.-c

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
53. 加藤靖浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 桜井実

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
55. 中尾香菜子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 森貞章

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Souma Yoshirou 相馬 義郎

SOHMA Yoshiro 相馬 義郎

SOHMA YOSHIRO 有馬 義郎

SOUMA Yoshirou 相馬 義郎

相馬 義郎 ソウマ ヨシロウ

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study for the mechanism of functional expression and dysfunction of membrane proteins through direct observations of single molecular fluctuationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for functional mechanism of membrane protein complexes from the perspective of self-organization using single molecule direct observations.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of technical basis for direct observations of membrane protein complex in dynamic equilibrium under a physiological conditionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for mechanism of ABC transporters based on single molecular direct observations using high speed Atomic Force Microscopy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ＡＢＣトランスポータＮＢＤエンジンにおけるＡＴＰエネルギー利用メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Souma Yoshirou 相馬義郎

SOHMA Yoshiro 相馬義郎

SOHMA YOSHIRO 有馬義郎

SOUMA Yoshirou 相馬義郎

相馬義郎ソウマヨシロウ