ARAI Masashi 新井昌史

… Alternative Names

荒井昌史アライマサシ

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Researcher Number	60270857
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2011 – 2012: 群馬大学, 医学(系)研究科(研究院), 准教授 2007 – 2010: Gunma University, Graduate School of Medicine, Department of Medicine and Biological Science, Associate Professor 2000 – 2007: GUNMA UNIVERSITY SCHOOL OF MEDICINE, ASSISTANT PROFESSOR, 医学部, 講師 2005: 医学部, 講師 1995 – 1999: Gunma University School of Medicine 2nd Dept of Int Med, Assistant, 医学部, 助手 1998: 助手 1996: 群馬大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine
Keywords	Principal Investigator SERCA2 / 心不全 / sarcoplasmic reticulum / 心筋小胞体 / phospholamban / gene transcription / heart failure / 遺伝子転写 / Egr-1 / gene therapy … More / 遺伝子治療 / calcium / カルシウム / RNA interference / RNA干渉法 / ホスホランバン / Ca2+-ATPase / Sp1 / ERK / doxorubicin / MAPK / 活性酸素 / ドキソルビシン / 脳性利尿ペプチド / トランスジェニックマウス / 心機能 / レンチウイルスベクター / vector / lentivirus / adeno-associated virus / Ca^<2+>-ATPase / ベクター / レンチウイルス / アデノ随伴ウイルス / pressure overload / MAP kinase / Egy-1 / ドルソルビシン / 圧負荷 / reactive oxygen / 転写 / セラミド / 過酸化水素 / 遺伝子発現 / calcium pump / transgenic mice / proton antiporter / sodium / cardiac hypertrophy / calsequestrin / カルシウムオーバーレイ / 水素交換 / カルシウム貯蔵量 / ナトリウム水素交換担体 / カルシウムポンプ / 水素交換担体 / ナトリウム / 心臓肥大 / カルセクエストリン / 高血圧性心肥大 / 肺高血圧症 / 負荷心エコー / 左心房 / バイオマーカー / 駆出率 / I型コラーゲン / 結合組織増殖因子 / 拡張機能障害 / LacZ遺伝子 / 遺伝子プロモーター / 骨髄移植 / 血管新生 / 平滑筋ミオシン / 血管平滑筋細胞 / 血管内皮細胞 … More Except Principal Investigator 動脈硬化 / 転写因子 / CARP / 血管平滑筋細胞 / TGFβ / プロモーター / BTEB2 / SM1 / 遺伝子発現 / 遺伝子 / 老化 / 平滑筋 / 血管 / 腎不全 / Klotho / Smad / ミオシン / 再狭窄 / Gene expression / 低酸素 / p53 / SRF / 心肥大 / シグナル伝達 / 平滑筋細胞 / エンドセリン / 内皮細胞 / klotho / transcription factor / 形質変換 / 2 GENE, / MYOSIN, / SMOOTH MUSCLE, / SMemb / 血管平滑筋 / 遺伝子転写 / ミオシン重鎖 / 糖尿病 / スタチン / アポトーシス / サイトカイン / 細胞外マトリックス / アンキリン / 血管内皮細胞 / アデノウイルス / 分化 / BNP / Differentiation / Signaling / Diabetes / Atheroscelrosis / Transcription factor / Smooth muscle cell / Calcification / 細胞内情報伝達機構 / BMP2 / カルシウム / シグナル / 石灰化 / pressure overload / hypertrophy / reperfusion / ischemia / leptin receptor / leptin / 圧負荷 / 虚血再灌流 / レプチン受容体 / レプチン / Signal transduction / Artery / Mitochondria / Atherosclerosis / Hypoxia / Vascular smooth cell / PAI-1 / 血管新生 / 活性酸素種 / HIF-1α / チロシンキナーゼ / ミトコンドリア / endothelin-1 / promoter / lipopolysaccharide / angiotensin II / transcriptional factor / tumor necrosis factor-α / エンドセリン-1 / リポポリサッカライド / アンジオテンシンII / 腫瘍壊死因子 / smooth muscle cell / gene expression / atherosclerosis / p21 / コファクター / GENE EXPRESSION / SIGNALING / ANKYRIN / PROMOTER / TGF-β / VASCULAR SMOOTH MUSCLE CELL / TRANSCRIPTION / イソプロテノール / SHR / 心不全 / 転写 / Hex / ストレス応答 / CAGA / 細胞周期 / Endothelin / Heart Failure / Hypertrophy / Gene / Transcription / Stress / Heart / NFkB / 酸化ストレス / Mn-SOD / アドリアマイシン / p38 / Rac1 / Sp1 / 細胞障害 / KLOTHO / HYPERTENSION / HUMORAL FACTOR / PARABIOSIS / NITRIC OXIDE / ENDOTHELIUM / AGING / aging / 老化抑制遺伝子 / 高血圧 / 高血圧症 / 液性因子 / 並体結合 / 一酸化窒素 / ^<113>Xe / radioactive stent / intracoronary radiation / phenotypic modulation / smooth muscle cells / 血管内照射 / 冠動脈 / 新生内膜 / 192Ir / ガンマ線 / 血管内照射療法 / 内膜肥厚 / ステント / 133Xe / レチノイン酸 / イオン注入 / ^<133>Xe / 放射活性ステント / PTCA / TRANSCRIPTION FACTOR, / SMemb GENE, / RESTENOSIS, / 2 / IMMUNOASSAY / AGING, / AORTIC DISSECTION, / TRANSGENIC MOUSE, / ATHEROSCLEROSIS, / 遺伝子導入 / 大動脈解離 / 血管障害 / 解離性大同脈瘤 / イムノアッセイ / 2遺伝子 / トランスジェニックマウス / 解離性大動脈瘤 / 骨形成 / Notchシグナル / 慢性腎臓病 / 血管生物学 / 細胞分化 / FGF23 / 慢性腎不全 / AGE / Notch / 血管石灰化 / 骨芽細胞 / PI-3キナーゼ / Akt / TNFα / PI3キナーゼ / CREB / NOS / プロスタサイクリン / ATF2 / TRAIL / ゲルシフト / 核内因子 / ホメオ蛋白 / PPAR_γ / THP-1細胞 / PPARγ / ホメオボックス / マクロファージ / オステオポンチン / PRB / TGF / 心筋細胞 / Ca^<2+>-ATPase / ANP / バルーン傷害 / リモデリング Less

駆出率保持性心不全発症をもたらす心血管系因子の解明と治療法への応用Principal Investigator
- Principal Investigator
  
  新井昌史
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Molecular mechanism of vascular calcification in chronic kidney disease
- Principal Investigator
  
  KURABAYASHI Masahiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
結合組織増殖因子による心臓線維化・拡張不全発症機序の解明と診断法、治療法の開発Principal Investigator
- Principal Investigator
  
  新井昌史
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Molecular Mechanism of Vascular Calcification
- Principal Investigator
  
  KURABAYASHI Masahiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Establishment of novel therapeutic strategy for heart failure by modulating the function of cardiac contractile and relaxation proteinsPrincipal Investigator
- Principal Investigator
  
  ARAI Masashi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Molecular Mechanisms of Vasa Vasorum Angiogenesis and Dysregulation of Vascular Smooth Muscle Cell Differentiation
- Principal Investigator
  
  KURABAYASHI Masahiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Mechanisms of leptin receptor isoforms expression in heart diseases
- Principal Investigator
  
  YOKOYAMA Tomoyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
血管内皮細胞におけるTNFα関連アポトーシス誘導因子TRALの機能の解明
- Principal Investigator
  
  倉林正彦
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Development of novel therapeutic strategy for heart failure by improving Ca2+ transport function of sarcoplasmic reticulumPrincipal Investigator
- Principal Investigator
  
  ARAI Masashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Functional Analysis of p53-Regulatory Protein CARP in Atherosclerosis
- Principal Investigator
  
  KURABAYASHI Masahiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Regulation of the tumor necrosis factor-α promoter in the development of heart failure
- Principal Investigator
  
  YOKOYAMA Tomoyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma university
マクロファージにおけるPPARγを介する動脈硬化関連遺伝子の発現抑制機構の解明
- Principal Investigator
  
  倉林正彦
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Development of novel heart failure therapy by using gene transfer into cardiac myocytesPrincipal Investigator
- Principal Investigator
  
  ARAI Masashi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Gunma University
血管壁細胞における代血管特異的因子CARPの機能解析
- Principal Investigator
  
  倉林正彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gunma University
成体における血管前駆細胞の固定と血管病態での役割の検討Principal Investigator
- Principal Investigator
  
  新井昌史
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gunma University
Transcriptional Regulation of the cardiovaocular genes in respone to stress
- Principal Investigator
  
  KURABAYASHI Masahiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Transcriptional regulation of the SERCA2 gene during the development of heart failurePrincipal Investigator
- Principal Investigator
  
  ARAI Masashi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Gunma University School of Medicine
転写因子による血管新生とその抑制の分子機構の解明
- Principal Investigator
  
  KURABAYASHI Masahiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gunma University
Klotho欠損マウスにおける心筋細胞の分化異常に関する研究
- Principal Investigator
  
  倉林正彦
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Physiological function of ageing suppression gene klotho and its role in development of adult disease
- Principal Investigator
  
  NAGAI Ryozo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Molecular Mechanisms of Genetic Response of Myocardial Cells to Cytotoxic Stress
- Principal Investigator
  
  KURABAYASHI Masahiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Analyses of transcriptional regulation and signal transduction of sarcoplasmic reticulum Ca^<2+>Principal Investigator
- Principal Investigator
  
  ARAI Masashi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University School of Medicine
血管の老化と平滑筋増殖を制御する遺伝子の同定
- Principal Investigator
  
  NAGAI Ryozo
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Development of therapeutic methods for arterial restenosis : intraarterial radiation, pharmaceutical approach and gene therapy
- Principal Investigator
  
  NAGAI Ryozo
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University School of Medicine
The pathophysiological role of calsequestrin for the development of cardiac hypertrophyPrincipal Investigator
- Principal Investigator
  
  ARAI Masashi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University
Pathogenesis and molecular mechanisms of arteral restenosis
- Principal Investigator
  
  NAGAI Ryozo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University School of Medicine
  The University of Tokyo
Development of new diagnostic and therapeutic methods and animal models of cardiovascular diseases using smooth muscle myosin heavy chain isoforms.
- Principal Investigator
  
  NAGAI Ryozo
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gunma University School of Medicine
  The University of Tokyo

All 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Book

[Book] SERCA2 (SR Ca2+-ATPase) 日本臨床心不全最新の基礎臨床研究の進歩2007
- Author(s)
  新井昌史
- Total Pages
  5
- Publisher
  日本臨床社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Book] 心臓ナビゲーター2004
- Author(s)
  新井昌史
- Total Pages
  2
- Publisher
  メディカルレビュー社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590717
[Journal Article] 心病態形成におけるシンデカン-4の役割と心不全診断への応用2012
- Author(s)
  新井　昌史
- Journal Title
  
  日本臨床生理学会雑誌
  
  Volume: 42 Pages: 65-70
- Data Source
  KAKENHI-PROJECT-23591029
[Journal Article] 心不全の病態形成因子と治療目標としての心筋小胞体Ca2+-ATPase,SERCA22012
- Author(s)
  新井　昌史
- Journal Title
  
  日本薬理学会雑誌
  
  Volume: 140 Pages: 259-264
- Data Source
  KAKENHI-PROJECT-23591029
[Journal Article] Notch signaling induces osteogenic differentiation and mineralization of vascular smooth muscle cells: role of Msx2 gene induction via Notch-RBP-Jk signaling.2010
- Author(s)
  Shimizu T, Tanaka T, Iso T, Doi H, Sato H, Kawai-Kowase K, Arai M, Kurabayashi M.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 29(7)
  
  Pages: 1104-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390216
[Journal Article] Fibroblast growth factor-2 induces osteogenic differentiation through a Runx2 activation in vascular smooth muscle cells.2010
- Author(s)
  Nakahara T, Sato H, 1 . Shimizu T, Tanaka T, Matsui H, Kawai-Kowase K, Sato M, Iso T, Arai M, Kurabayashi M.
- Journal Title
  
  Biochem Biophys Res Commun. 394
  
  Pages: 243-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390216
[Journal Article] Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion formation.2009
- Author(s)
  Doi H, Iso T, Shiba Y, Sato H, Yamazaki M, Oyama Y, Akiyama H, Tanaka T, Tomita T, Arai M, Takahashi M, Ikeda U, Kurabayashi M.
- Journal Title
  
  Biochem Biophys Res Commun. 381(4)
  
  Pages: 654-659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390216
[Journal Article] PIAS1 mediates TGFbeta-induced SM alpha-actin gene expression through inhibition of KLF4 function-expression by protein sumoylation.2009
- Author(s)
  Kawai-Kowase K, Ohshima T, Matsui H, Tanaka T, Shimizu T, Iso T, Arai M, Owens GK, Kurabayashi M.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 29(1)
  
  Pages: 99-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390216
[Journal Article] Plasma Connective Tissue Growth Factor is a Novel Potential Biomarker of Cardiac Dysfunction in Patients with Chronic Heart Failure2008
- Author(s)
  Koitabashi N, Arai M, Niwano K, Watanabe A, Endoh M, Suguta M, Yokoyama T, Tada H, Toyama T, Adachi H, Naito S, Oshima S, Nishida T, Kubota S, Takigawa M, Kurabayashi M
- Journal Title
  
  Eur J Heart Fail
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659195
[Journal Article] Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells2008
- Author(s)
  Tanaka T, Sato H, Doi H, Yoshida CA, Shimizu T, Matsui H, Yamazaki M, Akiyama H, Kawai-Kawase K., Iso T, Komori T, Arai M, Kurabayashi M.
- Journal Title
  
  Mol Cell Biol 28
  
  Pages: 1147-60
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390227
[Journal Article] Increased connective tissue growth factor relative to brain natriuretic peptide as a deterninat of myocardial fibrosis2007
- Author(s)
  Koitabashi N, Arai M, Kogure S, Niwano K, Watamabe A, Aoki Y, Maeno T, Nishida T, Kubota S, Takiawa M, Kurabaashi M.
- Journal Title
  
  Hypertension 49
  
  Pages: 1120-1127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659195
[Journal Article] レンチウイルスベクターによるSERCA2遺伝子導入はラット実験的心筋梗塞による心不全を改善し、左室リモデリングを抑制する2007
- Author(s)
  新井昌史, 庭野和生
- Journal Title
  
  日薬理誌 129
  
  Pages: 1-8
- NAID
  130007039588
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Increased Connective Tissue Growth Factor Relative to Brain Natriuretic Peptide as a Determinant of Myocardial Fibrosis.2007
- Author(s)
  Koitabashi N, Arai M, Kogure S, Niwano K, Watanabe A, Aoki Y, Maeno T, Nishida T, Kubota S, Takigawa M, Kurabayashi M.
- Journal Title
  
  Hypertension. 49
  
  Pages: 1-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Increased Connective Tissue Growth Factor Relative to Brain Natriure tic Peptide as a Determinant of Myocardial Fibrosis.2007
- Author(s)
  Koitabashi N, Arai M, Kogure S, Niwano K, Watanabe A, Aoki Y, Maeno T, Nishida T, Kubota S, Takigawa M, Kurabayashi M
- Journal Title
  
  Hypertension 49
  
  Pages: 1-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Jagged1-selective notch signaling induces smooth muscle differentiation via a RBP-Jkappa-dependent pathway.2006
- Author(s)
  Doi H, Iso T, Sato H, Yamazaki M, Matsui H, Tanaka T, Manabe I, Arai M, Nagai R, Kurabayashi M.
- Journal Title
  
  J Biol Chem. 281
  
  Pages: 28555-28564
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Jagged 1-selective Notch Signaling Induces Smooth Muscle Differentiation via a RBP-J{kappa}-dependent Pathway.2006
- Author(s)
  Doi H, Iso T, Sato H, Yamazaki M, Matsui H, Tanaka T, Manabe I, Arai M, Nagai R, Kurabayashi M
- Journal Title
  
  J Biol Chem. 281
  
  Pages: 28555-28564
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Jaggedl-selective Notch Signaling Induces Smooth Muscle Differentiation via a RBP-J{kappa}-dependent Pathway.2006
- Author(s)
  Doi H, Iso T, Sato H, Yamazaki M, Matsui H, Tanaka T, Manabe I, Arai M, Nagai R, Kurabayashi M.
- Journal Title
  
  J Biol Chem. 281
  
  Pages: 28555-64
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Competitive Binding of CREB and ATF2 to cAMP/ATF Responsive Element Regulates eNOS Gene Expression in Endothelial Cells.2006
- Author(s)
  Niwano K, Arai M, Koitabashi N, Hara S, Watanabe A, Sekiguchi K, Tanaka T, Iso T, Kurabayashi M
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 26(5)
  
  Pages: 1036-1042
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390216
[Journal Article] Competitive binding of CREB and ATF2 to cAMP/ATF responsive element regulates eNOS gene expression in endothelial cells.2006
- Author(s)
  Niwano K, Arai M, Koitabashi N, Hara S, Watanabe A, Sekiguchi K, Tanaka T, Iso T, Kurabayashi M
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 26
  
  Pages: 1036-1042
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] D114-selective Notch signaling induces ephrinB2 gene expression in endothelial cells.2006
- Author(s)
  Iso T, Maeno T, Oike Y, Yamazaki M, Doi H, Arai M, Kurabayashi M
- Journal Title
  
  Biochem Biophys Res Commun. 341
  
  Pages: 708-714
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Jagged1-selective notch signaling induces smooth muscle differentiation via a RBP-Jkappa-dependent pathway2006
- Author(s)
  Doi H, Iso T, Sato H, Yamazaki M, Matsui H, Tanaka T, Manabe I, Arai M, Nagai R, Kurabayashi M.
- Journal Title
  
  J Biol Chem 281
  
  Pages: 28555-28564
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390227
[Journal Article] Competitive binding of CREB and ATF2 to cAMP/ATF responsive element regulates eNOS gene expression in endothelial cells.2006
- Author(s)
  Niwano K, Arai M, Koitabashi N, Hara S, Watanabe A, Sekiguchi K, Tanaka T, Iso T, Kurabayashi M.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 26
  
  Pages: 1036-42
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Competitive binding of CREB and ATF2 to cAMP/ATF responsive element regulates eNOS gene expression in endothelial cells.2006
- Author(s)
  Niwano K, Arai M, Koitabashi N, Hara S, Watanabe A, Sekiguchi K, Tanaka T, Iso T, Kurabayashi M.
- Journal Title
  
  Arterioscler Thromb Vase Biol. 26
  
  Pages: 1036-1042
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Competitive binding of CREB and ATF2 to cAMP/ATF responsive element regulates eNOS gene expression in endothelial cells.2006
- Author(s)
  Niwano K, Arai M, et al.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 26
- Data Source
  KAKENHI-PROJECT-18390227
[Journal Article] Dll4-selective Notch signaling induces ephrinB2 gene expression in endothelial cells.2006
- Author(s)
  Iso T, Maeno T, Oike Y, Yamazaki M, Doi H, Arai M, Kurabayashi M.
- Journal Title
  
  Biochem Biophys Res Commun. 341
  
  Pages: 708-714
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Competitive Binding of CREB and ATF2 to cAMP/ATF Responsive Element Regulates eNOS Gene Expression in Endothelial Cells.2006
- Author(s)
  Niwano K, Arai M et al.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 26
  
  Pages: 1036-1042
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390216
[Journal Article] Dll4-selective Notch signaling induces ephrinB2 gene expression in endothelial cells.2006
- Author(s)
  Iso T, Maeno T, Oike Y, Yamazaki M, Doi H, Arai M, Kurabayashi M
- Journal Title
  
  Biochem Biophys Res Commun. 341
  
  Pages: 708-14
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] D114-selective Notch signaling induces ephrin B2 gene Expression in endothelial cells2006
- Author(s)
  Iso T, Maeno T, Oike Y, Yamazaki M, Doi H, Arai M. Kurabayashi M.
- Journal Title
  
  Biochem Biophy Res Comm 341
  
  Pages: 708-714
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390227
[Journal Article] 心血管領域における遺伝子治療2006
- Author(s)
  新井昌史
- Journal Title
  
  綜合臨牀 55
  
  Pages: 1925-1927
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] D114-selective Notch signaling induces ephrinB2 gene expression in endothelial cells.2006
- Author(s)
  Iso T, Maeno T, Oike Y, Yamazaki M, Doi H, Arai M, Kurabayashi M
- Journal Title
  
  Biochem Biophys Res Commun. 341(3)
  
  Pages: 708-714
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390216
[Journal Article] Carvedilol effectively blocks oxidative stress-mediated downregulation of sarcoplasmic reticulum Ca(2+)-ATPase 2 gene transcription through modification of Sp1 binding.2005
- Author(s)
  Koitabashi N, Arai M, Tomaru K, Takizawa T, Watanabe A, Niwano K, Yokoyama T, Wuytack F, Periasamy M, Nagai R, Kurabayashi M.
- Journal Title
  
  Biochem Biophys Res Commun. 328
  
  Pages: 116-124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590717
[Journal Article] Carvedilol effectively blocks oxidative stress-mediated downregulation of sarcoplasmic reticulum Ca(2+)-ATPase 2 gene transcription through modification of Sp1 binding.2005
- Author(s)
  Koitabashi M, Arai M, Yokoyama T et al.
- Journal Title
  
  Biochem Biophys Res Commun 328(1)
  
  Pages: 116-124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590658
[Journal Article] 虚血性心筋症のリモデリング2005
- Author(s)
  新井昌史
- Journal Title
  
  Ischemic Heart Disease (IHD) Frontier 6
  
  Pages: 69-74
- NAID
  40007091491
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Carvedilol effectively blocks oxidative stress-mediated down regulation of sarcoplasmic reticulum Ca(2+)一ATPase 2 gene transcription through modification of Sp1 binding.2005
- Author(s)
  Koitabashi M, Arai M, Yokoyama T他
- Journal Title
  
  Biochem Biophys Res Common. 328(1)
  
  Pages: 116-124
- Data Source
  KAKENHI-PROJECT-16590658
[Journal Article] Cardiac sarcoidosis detected by FDG-PET2005
- Author(s)
  Goto K, Okamoto E, Morita M, Sasamoto T, Endo M, Umezawa K, Suguta M, Kaneko Y, Nakano A, Arai M, Hasegawa A, Kurabayashi M.
- Journal Title
  
  日本内科学会雑誌 94
  
  Pages: 1396-1398
- NAID
  130000896922
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Carvedilol effectively blocks oxidative stress-mediated downregulation of sarcoplasmic reticulum Ca(2+)-ATPase 2 gene transcription through modification of Sp1 binding.2005
- Author(s)
  Koitabashi M, Arai M, Yokoyama T 他
- Journal Title
  
  Biochem Biophys Res Commun. 328(1)
  
  Pages: 116-124
- Data Source
  KAKENHI-PROJECT-16590658
[Journal Article] Cardiac sarcoidosis detected by FDG-PET2005
- Author(s)
  Goto K, Okamoto E, Morita M, Sasamoto T, Endo M, Umezawa K, Suguta M, Kaneko Y, Nakano A, Arai M, Hasegawa A, Kurabayashi M.
- Journal Title
  
  Nippon Naika Gakkai Zasshi. 94
  
  Pages: 1396-1398
- NAID
  130000896922
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Carvedilol effectively blocks oxidative stress-mediated downregulation of sarcoplasmic reticulum Ca2+-ATPase 2 gene transcription through modification of Sp1 binding.2005
- Author(s)
  Koitabashi N, Arai M, Tomaru K, Takizawa T, Watanabe A, Niwano K, Yokoyama T, Wuytack F, Periasamy M, Nagai R, Kurabayashi M
- Journal Title
  
  Biochem Biophys Res Commun. 328
  
  Pages: 116-116
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Carvedilol effectively blocks oxidative stress-mediated downregulation of sarcoplasmic reticulum Ca2+-ATPase 2 gene transcription through modification of Sp1 binding.2005
- Author(s)
  Koitabashi N, Arai M, Tomaru K, Takizawa T, Watanabe A, Niwano K, Yokoyama T, Wuytack F, Periasamy M, Nagai R, Kurabayashi M.
- Journal Title
  
  Biochem Biophys Res Commun. 328
  
  Pages: 116-124
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box.2005
- Author(s)
  Doi H, Iso T, Yamazaki M, Akiyama H, Kanai H, Sato H, Kawai-Kowase K, Tanaka T, Maeno T, Okamoto E, Arai M, Kedes L, Kurabayashi M
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 25(11)
  
  Pages: 2328-2334
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390216
[Journal Article] HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box.2005
- Author(s)
  Doi H, Iso T, Yamazaki M, Akiyama H, Kanai H, Sato H, Kawai-Kowase K, Tanaka T, Maeno T, Okamoto E, Arai M, Kedes L, Kurabayashi M.
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 25
  
  Pages: 2328-2334
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] Carvedilol effectively blocks oxidative stress-mediated downregulation of sarcoplasmic reticulum Ca(2+)-ATPase 2 gene transcription through modification of Sp1 binding.2005
- Author(s)
  Koitabashi M, Arai M, Yokoyama T他
- Journal Title
  
  Biochem Biophys Res Commun. 328(1)
  
  Pages: 116-124
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590658
[Journal Article] 活性酸素種2005
- Author(s)
  新井昌史
- Journal Title
  
  循環器科 57
  
  Pages: 614-622
- Data Source
  KAKENHI-PROJECT-17390224
[Journal Article] The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells.2004
- Author(s)
  Sato M, Tanaka T, Maemura K, Uchiyama T, Sato H, Maeno T, Suga T, Iso T, Ohyama Y, Arai M, Tamura J, Sakamoto H, Nagai R, Kurabayashi M.
- Journal Title
  
  Am J Respir Cell Mol Biol. 31
  
  Pages: 209-215
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590717
[Journal Article] Usefulness of fasting 18F-FDG PET in identification of cardiac sarcoidosis.2004
- Author(s)
  Okumura W, Iwasaki T, Toyama T, Iso T, Arai M, Oriuchi N, Endo K, Yokoyama T, Suzuki T, Kurabayashi M.
- Journal Title
  
  J Nucl Med. 45
  
  Pages: 1989-1998
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590717
[Journal Article] Phospholamban ablation by RNA interference increases Ca2+ uptake into rat cardiac myocyte sarcoplasmic reticulum.2004
- Author(s)
  Watanabe A, Arai M, Yamazaki M, Koitabashi N, Wuytack F, Kurabayashi M
- Journal Title
  
  J Mol Cell Cardiol. 37
  
  Pages: 691-698
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590717
[Journal Article] Transcription factor Sp1 regulates SERCA2 gene expression in pressure overloaded hearts : A study using in vivo direct gene transfer into living myocardium2003
- Author(s)
  Takizawa T, Arai M, Tomaru K, Koitabashi N, Baker DL, Periasamy M, Kurabayashi M
- Journal Title
  
  J Mol Cell Cardiol. 35
  
  Pages: 777-783
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590717
[Journal Article] Transcriptional stimulation of the eNOS gene by the stable prostacyclin analogue beraprost is mediated through cAMP-responsive element in vascular endothelial cells : close link between PGI2 signal and NO pathways.2003
- Author(s)
  Niwano K, Arai M, Tomaru K, Uchiyama T, Ohyama Y, Kurabayashi M.
- Journal Title
  
  Circ Res. 93
  
  Pages: 523-530
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590717
[Journal Article] Regulation of the human tumor necrosis factor-alpha promoter by angiotensin II and lipopolysaccharide in cardiac fibroblasts : different cis-acting promoter sequences and transcriptional factors.2003
- Author(s)
  Sato H, Watanabe A, Tanaka T, Koitabashi N, Arai M, Kurabayashi M, Yokoyama T.
- Journal Title
  
  J Mol Cell Cardiol. 35
  
  Pages: 1197-1205
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590717
[Presentation] 血清シンデカン-4は心不全診断の新たなバイオマーカーである2011
- Author(s)
  新井　昌史
- Organizer
  日本臨床生理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591029
[Presentation] Osteogenic transcription factor Runx2 represses connective tissue growth factor gene expression and TGFbeta signaling in vascular smooth muscle cells.2010
- Author(s)
  Tanaka T., Shimizu T., Ohyama Y., Matsui H., Sato H., Iso T., Arai M., Kurabayashi M.
- Organizer
  The 72^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  福岡国際会議場(福岡)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20390216
[Presentation] Receptor for advanced-glycation end products (RAGE) induces Notch-Msx2-dependent osteoblastic differentiation of vascular smooth muscle cells.2010
- Author(s)
  Suga T., Iso T., Shimizu T., Tanaka T., Yamaguchi S., Arai M., Imaizumi T., Kurabayashi M.
- Organizer
  The 72^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  福岡国際会議場(福岡)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20390216
[Presentation] Notch and BMP2 Signaling converge at the Msx2 promoter to Induced osteogenic differentiation of vascular smooth muscle cells.2010
- Author(s)
  Shimizu T., Tanaka T., Iso T., Arai M.Kurabayashi M.
- Organizer
  The 72^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  福岡国際会議場(福岡)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20390216
[Presentation] Insulin accelerates osteoblastic differentiation of vascular smooth muscle cells through an induction of notch ligand jagged-1 in adjacent monocytes/macrophages.2010
- Author(s)
  Shimizu T., Tanaka T., Iso T., Arai M., Kurabayashi M.
- Organizer
  The 72^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  福岡国際会議場(福岡)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20390216
[Presentation] Activation of Receptor for Advanced-Glycation End Products (Rage) Induces Notch-msx2-Dependent Osteoblastic Differentiation of Vascular Smooth Muscle Cells.2008
- Author(s)
  Suga T., Iso T., Shimizu T., Tanaka T., Arai M., Yamagishi S., Kurabayashi M.
- Organizer
  Annual meeting of American Heart Association
- Place of Presentation
  New Orleans
- Year and Date
  2008-11-07
- Data Source
  KAKENHI-PROJECT-20390216
[Presentation] Stearoyl-coa Desaturase-1 Protects Against Saturated Fatty Acids-Induced Osteogenic Differentiation and Apoptosis of Vascular Smooth Muscle Cells.2008
- Author(s)
  Matsui H., Yokoyama T., Sekiguchi K., Gotoh Y., Iso T., Arai M., Kurabayashi M.
- Organizer
  Annual meeting of American Heart Association
- Place of Presentation
  New Orleans
- Year and Date
  2008-11-11
- Data Source
  KAKENHI-PROJECT-20390216
[Presentation] 血管石灰化とプラークの破綻2008
- Author(s)
  倉林正彦、清水岳久、田中亨、磯達也、須賀俊博、大山善昭、佐藤浩子、新井昌史
- Organizer
  第8回日本抗加齢医学会総会
- Place of Presentation
  京王プラザホテル(東京)
- Year and Date
  2008-06-07
- Data Source
  KAKENHI-PROJECT-20390216
[Presentation] Notch Signaling Induces Expression of Fatty Acid Binding Protein 4 via Induction of PPAR-γ 2 in Capillary Endothelial Cells in Heart.2008
- Author(s)
  Iso T., Suga T., Matsui H., Arai M., Kurabayashi M.
- Organizer
  Annual meeting of American Heart Association
- Place of Presentation
  New Orleans
- Year and Date
  2008-11-08
- Data Source
  KAKENHI-PROJECT-20390216
[Presentation] Osteogenic transcription factor Runx2 represses CTGF expression and TGFb signaling in vascular smooth muscle cells2007
- Author(s)
  Tanaka T, Shimizu T, Iso T, Suga T, Arai M, Kurabayashi M
- Organizer
  American Heart Association Scientific Session
- Place of Presentation
  Orlando, Florida
- Year and Date
  2007-11-04
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390227
[Presentation] Nocth signaling accelerates vascular smooth muscle differentiation by inducing myocardin gene expression and by enhancing the transactivating function of myocardin2007
- Author(s)
  Doi H, Iso T, Sato H, Tanaka T, Arai M, Kurabayashi M.
- Organizer
  American Heart Association Scientific Session
- Place of Presentation
  Orlando, Florida
- Year and Date
  2007-11-04
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390227
[Presentation] 圧負荷肥大心ではCCN2はBrain Natriuretic Peptideと拮抗して心臓線維化をもたらす2007
- Author(s)
  新井昌史, 小板橋紀通, 西田崇, 久保田聡, 滝川正春、倉林正彦
- Organizer
  第1回CCNファミリー研究会
- Place of Presentation
  岡山市
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-19659195
[Presentation] Notch signaling enhances BMP-2-mediated osteogenic conversion of vascular smooth cells through a synergistic induction of Msx2 gene expression2006
- Author(s)
  Shimizu T, Tanala T, Doi H, Iso T, Arai M, Kurabayashi M
- Organizer
  American Heart Association Scientific Session
- Place of Presentation
  Chicag, Illinoi
- Year and Date
  2006-11-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390227

1. KURABAYASHI Masahiko (00215047)

# of Collaborated Projects: 21 results

# of Collaborated Products: 46 results
2. NAGAI Ryozo (60207975)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. NAKAMURA Tetsuya (10272238)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. NABESHIMA Youich (60108024)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YOKOYAMA Tomoyuki (70312890)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. KURO-O Makoto

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 中原賢一

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. HASEGAWA Akira (80156306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. UTSUGI Toshihiro (10282386)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 花岡和則 (40189577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山崎力 (60251245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 世古義規 (30240708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 西村敬史

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ARAI Masashi 新井 昌史

荒井 昌史 アライ マサシ

Research Projects

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駆出率保持性心不全発症をもたらす心血管系因子の解明と治療法への応用Principal Investigator

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結合組織増殖因子による心臓線維化・拡張不全発症機序の解明と診断法、治療法の開発Principal Investigator

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Establishment of novel therapeutic strategy for heart failure by modulating the function of cardiac contractile and relaxation proteinsPrincipal Investigator

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Development of novel therapeutic strategy for heart failure by improving Ca2+ transport function of sarcoplasmic reticulumPrincipal Investigator

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Development of novel heart failure therapy by using gene transfer into cardiac myocytesPrincipal Investigator

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成体における血管前駆細胞の固定と血管病態での役割の検討Principal Investigator

Principal Investigator

ARAI Masashi 新井昌史

荒井昌史アライマサシ