AMAGASE KIKUKO 天ヶ瀬紀久子

… Alternative Names

Amagase Kikuko 天ヶ瀬紀久子

AMAGASE Kikuko 天ヶ瀬紀久子

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Researcher Number	60278447
Other IDs
Affiliation (Current)	2025: 立命館大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2023: 立命館大学, 薬学部, 教授 2018 – 2022: 立命館大学, 薬学部, 准教授 2014 – 2016: 京都薬科大学, 薬学部, 講師 1997 – 2000: 京都薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 47040:Pharmacology-related / Pharmacology in pharmacy Except Principal Investigator Biological pharmacy / Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator 抗がん剤 / 小腸炎 / グルタミン酸 / 薬剤性腸炎 / 線維化 / 炎症性腸疾患 / 線維化大腸炎 / 大腸炎 / ポリグルタミン酸 / ヘリコバクターピロリ関連胃疾患 / Helicobacter pylori … More Except Principal Investigator … More NSAID / Mongolian gerbil / Helicobacter pylori / プロスタグランジン / CINC / 砂ネズミ / ヘリコバクター・ピロリ / 活性酸素種 / NADPH オキシダーゼ / 拡張機能不全型心不全 / NADPHオキシダーゼ / 細胞外マトリックス / NADPH oxidase / 細胞外マトリクス / 心線維化 / Delayed ulcer healing / Prostaglandin / Angiogenesis / Aceti acid ulcer / Cytokines / 抗炎症薬 / COX-2選択的阻害薬 / ヘリコバクターピロリ / 潰瘍治癒遅延 / 血管新生 / 酢酸潰瘍モデル / サイトカイン / prostaglandin / gastric mucuc / gastric acid / neutrophil / gastric ulcer / 胃炎 / 粘液 / 胃酸 / 好中球 / 胃潰瘍 Less

腸管線維化に着目した炎症性腸疾患の病態解明と新規治療法の提案Principal Investigator
- Principal Investigator
  
  天ヶ瀬紀久子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Ritsumeikan University
New therapeutic strategies for diastolic heart failure using extracellular matrix
- Principal Investigator
  
  Iwata Kazumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Application of glutamine and glutamate in the treatment of inflamatory intestinal disordersPrincipal Investigator
- Principal Investigator
  
  Amagase Kikuko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Ritsumeikan University
Ameliorative effect of glutamate on Helicobacter pylori-related gastropathyPrincipal Investigator
- Principal Investigator
  
  Amagase Kikuko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Kyoto Pharmaceutical University
抗炎症薬による胃損傷誘発・潰瘍治癒遅延作用とそれらの機序の分子レベルでの解明
- Principal Investigator
  
  OKABE Susumu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Mechanism by which Helicobacter pylori infection causes gastric ulcers Mongolian gerbils
- Principal Investigator
  
  OKABE Susumu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto Pharmaceutical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Orally Administrated Glutamate Restored EAAT1 and 3 Expression Levels Suppressed in 5-Fluorouracil-damaged Intestinal Epithelial Cells2024
- Author(s)
  JONAN SHIZUKA、HANEDA MAI、AMAGASE KIKUKO
- Journal Title
  
  Anticancer Research
  
  Volume: 44 Issue: 3 Pages: 1143-1147
- DOI
  10.21873/anticanres.16909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06506
[Journal Article] Cytology-based Detection of Circulating Tumour Cells in Human Pancreatic Cancer Xenograft Models With KRAS Mutation2020
- Author(s)
  ITO YUKAKO、INOUE ERIKO、MATSUI YUKI、KOBUCHI SHINJI、MOYAMA CHIAMI、AMAGASE KIKUKO、YOSHIMURA MAYUMI、IKEHARA YUZURU、NAKATA SUSUMU、NAKANISHI HAYAO
- Journal Title
  
  Anticancer Research
  
  Volume: 40 Issue: 12 Pages: 6781-6789
- DOI
  10.21873/anticanres.14701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07682, KAKENHI-PROJECT-18K06692, KAKENHI-PROJECT-18K06765
[Journal Article] Leukotriene B4 receptor type 2 (BLT2) accelerates the healing of intestinal lesions by promoting epithelial cell proliferation2020
- Author(s)
  Matsumoto Y, Matsuya Y, Kano N, Amagase K, Saeki K, Matsumoto K, Yokomizo T, Kato S
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 373 Issue: 1 Pages: 1-9
- DOI
  10.1124/jpet.119.263145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06692, KAKENHI-PROJECT-19K07109, KAKENHI-PROJECT-19KK0199, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-18H02627, KAKENHI-PROJECT-18K06923
[Journal Article] Roles of Up-regulated Expression of ASIC3 in Sex Difference of Acid-Induced Duodenal HCO3-Responses2020
- Author(s)
  Koji Takeuchi, Yumi Ohashi, Kikuko Amagase
- Journal Title
  
  Curr Pharm Des
  
  Volume: 26 Issue: 25 Pages: 3001-3009
- DOI
  10.2174/1381612826666200417170319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06692
[Journal Article] Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties, attenuates 5-fluorouracil-induced intestinal mucositis in mice through activation of extrinsic primary afferent neurons.2017
- Author(s)
  Sano T, Utsumi D, Amagase K, Matsumoto K, Tominaga M, Higuchi K, Takeuchi T, Kato S.
- Journal Title
  
  J Physiol Pharmacol.
  
  Volume: 68 Pages: 79-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460109
[Journal Article] Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5-Fluorouracil-induced Intestinal Mucositis in Mice.2017
- Author(s)
  Hamouda N, Sano T, Oikawa Y, Ozaki T, Shimakawa M, Matsumoto K, Amagase K, Higuchi K, Kato S.
- Journal Title
  
  Basic Clin Pharmacol Toxicol.
  
  Volume: in press Issue: 3 Pages: 159-168
- DOI
  10.1111/bcpt.12793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460109
[Journal Article] スナネズミにおけるヘリコバクターピロリ誘起胃粘膜病変に対する大草胃腸薬の保護作用.2016
- Author(s)
  天ヶ瀬紀久子、村上季子、熊谷みなみ、西村杏璃、岡　美里、河上ひかる、竹内孝治、大草貴之: スナネズミにおけるヘリコバクターピロリ誘起胃粘膜病変に対する大草胃腸薬の保護作用.
- Journal Title
  
  J. Pharmacol. Ther.
  
  Volume: 44 Pages: 1733-1739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460109
[Journal Article] Glutamate as a Potential Protective Drug in the Gastrointestinal Mucosa2015
- Author(s)
  天ヶ瀬紀久子、中村英志、加藤伸一、竹内孝治
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 135 Issue: 6 Pages: 779-782
- DOI
  10.1248/yakushi.14-00250-3
- NAID
  130005071775
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2015-06-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-26460109
[Presentation] 抗がん剤誘起小腸炎におけるグルタミン酸の有用性2024
- Author(s)
  上南静佳、加藤伸一、天ヶ瀬紀久子
- Organizer
  第51回日本潰瘍学会
- Data Source
  KAKENHI-PROJECT-23K06506
[Presentation] 慢性潰瘍性大腸炎の線維化に関与する因子の探索2023
- Author(s)
  大塚勇輝、佐々木礼一郎、天ヶ瀬紀久子
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K06506
[Presentation] 活性酸素種産生酵素 NADPHオキシダーゼ1が担うドキソルビシン誘発心毒性における役割．2023
- Author(s)
  深津陽大，天ヶ瀬紀久子，楳村敦詩，岩田和実.
- Organizer
  第143回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-21K06805
[Presentation] NOX1/NADPHオキシダーゼはアポトーシスを介しドキソルビシン誘発細胞傷害を増悪させる．2023
- Author(s)
  深津陽大，岩田和実，楳村敦詩，天ヶ瀬紀久子．
- Organizer
  次世代を担う若手のための創薬・医療薬理シンポジウム2023
- Data Source
  KAKENHI-PROJECT-21K06805
[Presentation] Role of NOX1/NADPH Oxidase in Doxorubicin-induced Cardiotoxicity.2023
- Author(s)
  Haruto Fukatsu, Kazumi Itawa, Kikuko Amagase.
- Organizer
  19th World Congress of Basic & Clinical Pharmacology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06805
[Presentation] Glutamate improves epithelial damage in intestinal mucositis caused by anticancer drug 5-Fluorouracil2023
- Author(s)
  Shizuka Jonan, Nahla Hamouda, Mai Haneda, Kikuko Amagase
- Organizer
  World Congress of Basic and Clinical Pharmacology 2023
- Data Source
  KAKENHI-PROJECT-23K06506
[Presentation] ドキソルビシンによる心筋細胞傷害におけるNOX1/NADPHオキシダーゼの役割.2022
- Author(s)
  深津陽大，岩田和実，松本みさき，天ヶ瀬紀久子
- Organizer
  次世代を担う若手のための創薬・医療薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06805
[Presentation] 活性酸素産生酵素NOX1/NADPHオキシダーゼのドキソルビシンによる心筋細胞傷害における役割2022
- Author(s)
  深津陽大，岩田和実，天ヶ瀬紀久子
- Organizer
  生体機能と創薬シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06805
[Presentation] グルタミン酸のがん化学療法剤起因性腸炎における有用性2021
- Author(s)
  ハモウダナハラ、増田侑哉、加藤大輔、上南静佳、加藤伸一、天ヶ瀬紀久子
- Organizer
  第48回日本潰瘍学会
- Data Source
  KAKENHI-PROJECT-18K06692
[Presentation] Role of glutamate against 5-fluorouracil induced intestinal mucositis in mice2020
- Author(s)
  Shizuka Jonan, Nahla Hamouda, Daisuke Kato, Yuya masuda, Kikuko Amagase
- Organizer
  1stAASP young scientist conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06692
[Presentation] 抗がん剤誘起性腸炎に対するGinsenoside Rdの効果2020
- Author(s)
  加藤大輔、大槻輝、増田侑哉、上南静佳、天ヶ瀬紀久子
- Organizer
  第70回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-18K06692
[Presentation] グルタミン酸の抗がん剤起因性腸炎に対する効果2020
- Author(s)
  加藤大輔、増田侑哉、ハモウダナハラ、加藤伸一、天ヶ瀬紀久子
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06692
[Presentation] NEW THERAPEUTIC STRATEGY FOR AMINO ACID: PROPHYLACTIC AND THERAPEUTIC EFFECT OF MONOSODIUM GLUTAMATE AGAINST GASTROINTESTINAL INFLAMMATION2020
- Author(s)
  Kikuko Amagase, Nahla Hamouda, Yuya Masuda, Daisuke Kato, Kenjiro Matsumoto, Shinichi Kato
- Organizer
  American Gastroenterological Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06692
[Presentation] 腸粘膜傷害の修復・治癒におけるロイコトリエン受容体タイプ2（BLT2）の役割2020
- Author(s)
  天ヶ瀬紀久子、松本　唯、山中勇人、松本健次郎、佐伯和子、横溝岳彦、加藤伸一
- Organizer
  第47回日本潰瘍学会
- Data Source
  KAKENHI-PROJECT-18K06692
[Presentation] がん化学療法剤誘起腸炎におけるグルタミン酸の役割2020
- Author(s)
  上南静佳、加藤大輔、増田侑哉、Nahla Hamouda、岩田和実、天ヶ瀬紀久子
- Organizer
  第41回日本臨床薬理学会
- Data Source
  KAKENHI-PROJECT-18K06692
[Presentation] 腸粘膜傷害の修復・治癒におけるロイコトリエンBLT2受容体の役割2019
- Author(s)
  松本　唯、野口岳寿、山中勇人、松本健次郎、天ヶ瀬紀久子、佐伯和子、横溝岳彦、加藤伸一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06692
[Presentation] ロイコトリエンB4 受容体2（BLT2）の腸傷害の修復・治癒における促進的役割.2019
- Author(s)
  次井晃宏、松本　唯、山中勇人、松本健次郎、天ヶ瀬紀久子、佐伯和子、横溝岳彦、加藤伸一
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2019
- Data Source
  KAKENHI-PROJECT-18K06692
[Presentation] Ameliorative Effect of Gultamate against Helicobacter pylori-Induced Gastritis in Mice2018
- Author(s)
  Kikuko Amagase, Yoshitaro Kano,Yuriko Kosaka, Kenjiro Matsumoto, Shinichi Kato
- Organizer
  10th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06692
[Presentation] Helicobacter pylori誘起胃粘膜病変に対するグルタミン酸の保護効果2017
- Author(s)
  加納嘉太郎、北居香菜子、宗本尚子、中井千秋、松本健次郎、天ヶ瀬紀久子、加藤伸一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  宮城県（仙台）
- Year and Date
  2017-03-26
- Data Source
  KAKENHI-PROJECT-26460109
[Presentation] グルタミンおよびグルタミン酸の薬剤起因性消化管傷害に対する保護効果2016
- Author(s)
  天ヶ瀬紀久子、岡田沙知、加納嘉太郎、松本健次郎、加藤伸一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26460109
[Presentation] Helicobacter pylori誘起胃粘膜病変に対するグルタミン酸の保護効果2015
- Author(s)
  天ヶ瀬紀久子、播磨弘樹、山崎華步、中村英志、竹内孝治、松本健次郎、加藤伸一
- Organizer
  第33回サイトプロテクション研究会
- Place of Presentation
  メルバルク京都（京都府・京都市）
- Year and Date
  2015-03-20
- Data Source
  KAKENHI-PROJECT-26460109
[Presentation] 薬剤誘起消化管粘膜傷害の病態解析と予防・治療薬に関する探索研究2015
- Author(s)
  天ヶ瀬紀久子
- Organizer
  生体機能と創薬シンポジウム2015
- Place of Presentation
  日本大学薬学部（千葉）
- Year and Date
  2015-08-28
- Data Source
  KAKENHI-PROJECT-26460109

1. OKABE Susumu (90012624)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TAKAHASHI Satoru (20268098)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Iwata Kazumi (60305571)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 加藤伸一 (90281500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 松本みさき (80533926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KANOU Yoshitaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. KITAI Kanako

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 池原譲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AMAGASE KIKUKO 天ヶ瀬 紀久子

Amagase Kikuko 天ヶ瀬 紀久子

AMAGASE Kikuko 天ヶ瀬 紀久子

Research Projects

Research Products

Co-Researchers

腸管線維化に着目した炎症性腸疾患の病態解明と新規治療法の提案Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New therapeutic strategies for diastolic heart failure using extracellular matrix

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Application of glutamine and glutamate in the treatment of inflamatory intestinal disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Ameliorative effect of glutamate on Helicobacter pylori-related gastropathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗炎症薬による胃損傷誘発・潰瘍治癒遅延作用とそれらの機序の分子レベルでの解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism by which Helicobacter pylori infection causes gastric ulcers Mongolian gerbils

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Orally Administrated Glutamate Restored EAAT1 and 3 Expression Levels Suppressed in 5-Fluorouracil-damaged Intestinal Epithelial Cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytology-based Detection of Circulating Tumour Cells in Human Pancreatic Cancer Xenograft Models With KRAS Mutation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Leukotriene B4 receptor type 2 (BLT2) accelerates the healing of intestinal lesions by promoting epithelial cell proliferation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of Up-regulated Expression of ASIC3 in Sex Difference of Acid-Induced Duodenal HCO3-Responses2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties, attenuates 5-fluorouracil-induced intestinal mucositis in mice through activation of extrinsic primary afferent neurons.2017

Author(s)

Journal Title

Data Source

[Journal Article] Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5-Fluorouracil-induced Intestinal Mucositis in Mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] スナネズミにおけるヘリコバクターピロリ誘起胃粘膜病変に対する大草胃腸薬の保護作用.2016

Author(s)

Journal Title

Data Source

[Journal Article] Glutamate as a Potential Protective Drug in the Gastrointestinal Mucosa2015

Author(s)

Journal Title

DOI

NAID

AMAGASE KIKUKO 天ヶ瀬紀久子

Amagase Kikuko 天ヶ瀬紀久子

AMAGASE Kikuko 天ヶ瀬紀久子