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HIGAKI Kazutaka  檜垣 和孝

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… Alternative Names

檜恒 和孝  ヒガキ カズタカ

檜垣 和孝  ヒガキ カズタカ

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Researcher Number 60284080
Other IDs
Affiliation (based on the past Project Information) *help 2021 – 2023: 岡山大学, 医歯薬学域, 教授
2016 – 2020: 岡山大学, 医歯薬学総合研究科, 教授
2011 – 2015: 岡山大学, 医歯(薬)学総合研究科, 教授
2014: 岡山大学, 大学院医歯薬学総合研究科, 教授
2009 – 2011: Okayama University, 大学院・医歯薬学総合研究科, 教授 … More
2008: 岡山大学, 医歯薬学総合研究科, 准教授
2007 – 2008: Okayama University, Graduate School of Medicine. Dentistry and Pharmaceutical Sciences, Associate Professor
2007: 岡山大学, 大学院・医歯薬学総合研究科, 助教
2006: Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Associate Professor, 大学院医歯薬学総合研究科, 助教授
2005 – 2006: Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授
2003 – 2004: 岡山大学, 薬学部, 助教授
1999 – 2001: Okayama University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授
1997: 岡山大学, 薬学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / 応用薬理学・医療系薬学 / Biological pharmacy
Except Principal Investigator
Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Basic Section 59040:Nutrition science and health science-related / Biological pharmacy
Keywords
Principal Investigator
腸神経系 / P-glycoprotein / enteric nervous system / Western blot / cephalexin / epinephrine / 消化管吸収 / セロトニン / clonidine / rhodamine123 … More / PepT1 / adrenaline / 刷子縁膜 / 受動拡散 / Cephalexin / PEPT1 / セロトニン代謝異常 / trafficking / 筋層間神経叢 / 粘膜下神経叢 / アドレナリン作動性神経系 / quinidine / 5-HT / oligopeptide transporter / enteric nerve system / myenteric plexus / 吸収促進 / 単純拡散 / bioavailability / BCRP / MRP2 / Caco-2細胞 / 分泌 / 有機アニオン系化合物 / antipyrine / bethanechol / セロトニン異常 / 経細胞経路 / 細胞間隙経路 / ベタネコール / 消化管内移行性 / アルカリフォスファターゼ / タンパク発現 / 尿細管再吸収 / PEPT2 / 滞留性 / gastrointestinal transit / 共培養系 / 腸神経細胞 / 分布容積 / 血漿蛋白結合 / α1-acid glycoprotein / Quinidine / FITC-dextran-4 / TEER / paracellular route / transcellular route / clorgyline / 慢性的セロトニン暴露 / 消化管内分泌 / 経口吸収動態 / 粘膜透過 / 膜抵抗値 / 粘膜透過性 / 経口投与 / 回腸 / 空腸 / 吸収増大 / Glycyl-Sarcosine / 水溶性高分子 / brush border membrane / dibutyryl cAMP / 腸管・血管同時灌流 / rhodamine 123 / submucosal plexus / colchicine / glycyl-sarcosine / cAMP / dobutamine / P-glycoproteir / absorption enhancement / gastrointestinal absorption / Voltage-clamp / p-chlorophenylalanine / serotonin(5-HT) / 消化管分泌 / cholinergic neuron / adrenergic neuron / 非アドレナリン作動性-非コリン作動性伝達物質 / 一酸化窒素 / 吸収抑制 / 交感神経系 / Auerbach神経叢 / Bethanechol / Epinephrine / Enteric nervous system / アウエルバッハ神経叢 / エピネフリン / コリン作動性神経 / アドレナリン作動性神経 / 平均滞留時間 / 腸移行速度 / 胃排出 / 小腸内滞留性 / GITA model / 非線形性 / 消化管内移行速度 / 経口吸収挙動 / セロトニン枯渇 / Caco-2 / 消化器疾患 / Ussing type chamber / 有機アニオン系薬物 / 発現タンパク / Mrp2 / ラット単離小腸粘膜 / FITC-dextran / クロム親和性細胞 / モノアミンオキシダーゼA / ローダミン123 / P-糖タンパク / 小腸粘膜 / トラフィッキンク / セロトニン症候群 / クロルギリン / P-糖タンパク質 / アドレナリン … More
Except Principal Investigator
ドラッグ・デリバリー・システム / 血管正常化 / がん治療 / 経口吸収 / CD44 / 乳がん / がん幹細胞 / 薬物送達 / GITA model / BCS class II / Cyp3A / P-gp / 血管新生 / 局所動態 / 抗腫瘍効果 / エマルション / リポソーム / 抗がん剤 / griseofulvin / 難水溶性薬物 / 初回通過効果 / Cytochrome P450 3A / P-glycoprotein / 消化管吸収 / 転移 / シグナル伝達 / トリプルネガティブ乳がん / 薬物送達法 / ALDH1A1 / CD44変異体 / スフェア培養 / エピジェネティック / 腸管上皮バリア / NASH / 異所性脂肪 / 慢性炎症 / RNA / 栄養エネルギー代謝 / RNAエピジェネティックス / ALKBH / 偏栄養 / ミトコンドリア / 食習慣 / 自己炎症 / 酸化ストレス / エピジェネティクス / インフラマソーム / RNAメチル化 / NAFLD/NASH / 血管内皮細胞 / 腫瘍内微小環境 / ドラッグデリバリーシステム / ナノ粒子 / 光線力学療法 / 新生血管 / in vitro dissolution study / prediction / poorly water-soluble drug / oral absorption / 吸収動態予測 / in vitro溶出試験 / 予測 / D-glucose transport / optimal culture condition / stratified cell layer / HaCaT cells / permeability evaluation / oral mucosa / D-glucose輸送系 / 最適培養条件 / 重層細胞 / HaCaT細胞 / 薬物透過性評価系 / 口腔粘膜 / transporter / facilitated diffusion / active transport / cultured stratified cell layer / dipeptide / D-glucose / human oral mucosal cells / トランスポータ / 促進拡散 / 能動輸送 / 培養重層細胞 / ジペプチド / D-グルコース / ヒト口腔粘膜上皮細胞 / 小腸抽出率 / 吸収クリアランス / 発現タンパク量 / quinidine / 経口窒収 / 経口投与 / SMEDDS製剤 / 補助界面活性剤 / 界面活性剤 / 油脂成分 / 自己乳化型マイクロエマルション / ムチン層 / グリセオフルビン / 放出 / 膵リパーゼ / 胆汁 / 自己乳化型マイクロエマルション製剤 / 自己乳化型マイクロエマルション製剤(SMEDDS) / 難溶解性薬物 / in vivo溶解挙動 / 小腸内移行性 / 胃排出 / PEPT1 / 代謝学 / 薬物動態 Less
  • Research Projects

    (20 results)
  • Research Products

    (60 results)
  • Co-Researchers

    (7 People)
  •  乳がんの増殖・転移を抑制可能な新規がん幹細胞標的療法の確立

    • Principal Investigator
      丸山 正人
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Okayama University
  •  Establishment of a novel drug delivery system for targeting cancer stem cells based on the structual analysis of tumor blood vesseles.

    • Principal Investigator
      Maruyama Masato
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Okayama University
  •  Effect of ENS dysfunction on drug absorption from small intestinePrincipal Investigator

    • Principal Investigator
      檜垣 和孝
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Okayama University
  •  Elucidation of liver mitochondrial failure and autoinflammation with RNA-epigenetics caused by nutrient stress

    • Principal Investigator
      TAKAYAMA Fusako
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Okayama University
  •  Development of novel DDS technology for effective treatment of refractory cancer

    • Principal Investigator
      Ogawara Ken-ichi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Kobe Pharmaceutical University
  •  Analysis of changes in intestinal drug absorption behavior caused by metabolic disorder of serotoninPrincipal Investigator

    • Principal Investigator
      Higaki Kazutaka
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Establishment of novel strategy in cancer treatments based on normalization of tumor vasculatures

    • Principal Investigator
      Ken-ichi Ogawara
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Analysis of drug absorption behavior under gastrointestintestinal diseases related with abnormal metabolism of serotoninPrincipal Investigator

    • Principal Investigator
      Higaki Kazutaka
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Establishment of novel strategy in cancer treatments based on modulation of microenvironment of tumor tissues

    • Principal Investigator
      OGAWARA Ken-ichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Analysis of drug absorption behavior in the enteric nervous system-related gastrointestinal diseasesPrincipal Investigator

    • Principal Investigator
      HIGAKI Kazutaka
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Analysis of dissolution kinetics and first-pass elimination of orally administered drugs and its application to prediction of absorption behavior after oral administration

    • Principal Investigator
      KIMURA Toshikiro
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Systematic analysis of ENS-regulation of drug absorptionPrincipal Investigator

    • Principal Investigator
      HIGAKI Kazutaka
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Analysis of first-pass effect in small intestinal mucosa and its application to prediction of drug absorption behavior after oral administration

    • Principal Investigator
      KIMURA Toshikiro
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Regulation of drug absorption by enteric nervous system: Studies on drug secretion via specialized mechanisms.Principal Investigator

    • Principal Investigator
      HIGAKI Kazutaka
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Analysis of physiological factors regulating oral absorption behaviors of drugs and its application to prediction of plasma concentration-time profile

    • Principal Investigator
      KIMURA Toshikiro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Okayama University
  •  Regulation of drug absorption and secretion from gastrointestinal via specialized mechanisms by enteric nervous systemPrincipal Investigator

    • Principal Investigator
      HIGAKI Kazutaka
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Analysis of Drug Permeation Mechanism across Oral Mucosa Using Cultured Stratified Cell Layers

    • Principal Investigator
      KIMURA Toshikiro
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Regulation of drug absorption from gastrointestinal tract by enteric nerve systemPrincipal Investigator

    • Principal Investigator
      HIGAKI Kazutaka
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Analysis of Carrier-Mediated Transport Systems in Drug Absorption from Oral Mucosa

    • Principal Investigator
      KIMURA Toshikiro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Effect of neurohumoral control on gastrointestinal absorption of drugsPrincipal Investigator

    • Principal Investigator
      OGAWARA Ken-ichi, 檜垣 和孝
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Okayama University

All 2023 2022 2020 2019 2017 2016 2014 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

  • [Book] 難水溶性薬物の物性評価と製剤設計の新展開第4章担体を利用した難水溶性薬物の製剤化1.自己乳化型製剤2010

    • Author(s)
      檜垣和孝, 他
    • Publisher
      シーエムシー
    • Data Source
      KAKENHI-PROJECT-21590158
  • [Journal Article] Possible Regulation of P-Glycoprotein Function by Adrenergic Agonists II: Study with Isolated Rat Jejunal Sheets and Caco-2 Cell monolayers2023

    • Author(s)
      Mukai Hironori、Takanashi Masashi、Ogawara Ken-ichi、Maruyama Masato、Higaki Kazutaka
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: accepted Issue: 5 Pages: 1209-1219

    • DOI

      10.1016/j.xphs.2023.11.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07176
  • [Journal Article] Establishment of a novel co-culture system of enteric neurons and Caco-2 cells for evaluating the effect of enteric nervous system on transepithelial transport of drugs2023

    • Author(s)
      Masato Maruyama, Minami Yoshikata, Mana Sakaguchi, Shizuka Wakushima, Kazutaka Higaki
    • Journal Title

      International Journal of Pharmaceutics

      Volume: 633 Pages: 122617-122617

    • DOI

      10.1016/j.ijpharm.2023.122617

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07176
  • [Journal Article] Effect of excessive serotonin on pharmacokinetics of cephalexin after oral administration: Studies with serotonin-excessive model rats2022

    • Author(s)
      Shun Nakashima, Takeharu Iwamoto, Masashi Takanashi, Ken-ichi Ogawara, Masato Maruyama, Kazutaka Higaki
    • Journal Title

      Pharmaceutical Research

      Volume: 39 Issue: 9 Pages: 2163-2178

    • DOI

      10.1007/s11095-022-03325-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07176
  • [Journal Article] Possible regulation of P-glycoprotein function by adrenergic agonists in a vascular-luminal perfused preparation of small intestine.2022

    • Author(s)
      Hironori Mukai, Masashi Takanashi, Ken-ichi Ogawara, Masato Maruyama, Kazutaka Higaki
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 110 Issue: 12 Pages: 3889-3895

    • DOI

      10.1016/j.xphs.2021.09.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07176
  • [Journal Article] Development of Safe and Potent Oil-in-Water Emulsion of Paclitaxel to Treat Peritoneal Dissemination2017

    • Author(s)
      Ogawara Ken-ichi、Fukuoka Yoshiko、Yoshizawa Yuta、Kimura Toshikiro、Higaki Kazutaka
    • Journal Title

      J. Pharm. Sci.

      Volume: 106 Issue: 4 Pages: 1143-1148

    • DOI

      10.1016/j.xphs.2016.12.029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08072
  • [Journal Article] Nanoparticle-Based Photodynamic Therapy: Current Status and Future Application to Improve Outcomes of Cancer Treatment2017

    • Author(s)
      Ogawara Ken-ichi、Higaki Kazutaka
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 65 Issue: 7 Pages: 637-641

    • DOI

      10.1248/cpb.c17-00063

    • NAID

      130006772442

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08072
  • [Journal Article] A novel approach to overcome multidrug resistance: Utilization of P-gp mediated efflux of paclitaxel to attack neighboring vascular endothelial cells in tumors2014

    • Author(s)
      Yoshizawa Y., Ogawara K., Kimura T., Higaki K.
    • Journal Title

      Eur. J. Pharm. Sci.

      Volume: 62 Pages: 274-280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590194
  • [Journal Article] Determinants for In Vivo Antitumor Effect of Angiogenesis Inhibitor SU5416 Formulated in PEGylated Emulsion2014

    • Author(s)
      Ogawara K., Abe S. Un K., Yoshizawa Y., Kimura T., Higaki K.
    • Journal Title

      J. Pharm. Sci.

      Volume: 103 Pages: 2464-2469

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590194
  • [Journal Article] Sex differences in pharmacokinetics of cilostazol in rats2011

    • Author(s)
      N. Kamada, K. Yamada, M. Odomi, T. Mukai, T. Nishibayashi, K. Ogawara, T. Kimura and K. Higaki
    • Journal Title

      Xenobiotica

      Volume: 41(10) Pages: 903-913

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590158
  • [Journal Article] 自己乳化型マイクロエマルション製剤2010

    • Author(s)
      檜垣和孝、木村聰城郎
    • Journal Title

      薬剤学 70

      Pages: 32-38

    • NAID

      10029100674

    • Data Source
      KAKENHI-PROJECT-21590158
  • [Journal Article]2010

    • Author(s)
      檜垣和孝
    • Journal Title

      難水溶性薬物の物性評価と製剤設計の新展開(シーエムシー出版)

      Pages: 151-160

    • Data Source
      KAKENHI-PROJECT-21590158
  • [Journal Article] 自己乳化型マイクロエマルション製剤2010

    • Author(s)
      檜垣和孝、木村聰城郎
    • Journal Title

      J. Pharm. Sci. Technol.

      Volume: 70(1) Pages: 32-38

    • NAID

      10029100674

    • Data Source
      KAKENHI-PROJECT-21590158
  • [Journal Article] オーラルメディケーションにおける胃排出の重要性2009

    • Author(s)
      檜垣和孝
    • Journal Title

      Pharm Tech Japan

      Volume: 25(13) Pages: 48-52

    • Data Source
      KAKENHI-PROJECT-21590158
  • [Journal Article] Effect of adrenergic stimulation on drug absorp- tion via passive diffusion in Caco-2 cells.2009

    • Author(s)
      T.Kimoto, M.Takanashi, H.Mukai, K.Ogawara, T.Kimura, K.Higaki
    • Journal Title

      Int.J.Pharm. 368(1-2)

      Pages: 31-36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590145
  • [Journal Article] 自己乳化型マイクロエマルション製剤による吸収改善2009

    • Author(s)
      檜垣和孝
    • Journal Title

      ファルマシア 45

      Pages: 1213-1216

    • Data Source
      KAKENHI-PROJECT-21590158
  • [Journal Article] Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats2009

    • Author(s)
      T. Hironaka, S. Itokawa, K. Ogawara, K. Higaki and T. Kimura
    • Journal Title

      Pharm. Res. 26(1)

      Pages: 40-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590144
  • [Journal Article] 自己乳化型マイクロエマルション製剤による吸収改善2009

    • Author(s)
      檜垣和孝
    • Journal Title

      Farumashia

      Volume: 45(12) Pages: 1213-1216

    • Data Source
      KAKENHI-PROJECT-21590158
  • [Journal Article] オーラルメディケーションにおける胃排出の重要性2009

    • Author(s)
      檜垣和孝
    • Journal Title

      ファームテクジャパン 25

      Pages: 2636-2640

    • Data Source
      KAKENHI-PROJECT-21590158
  • [Journal Article] Evaluation of in-vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug2008

    • Author(s)
      Y. Fujioka, Y. Metsugi, K. Ogawara, K. Higaki and T. Kimura
    • Journal Title

      Int. J. Pharm. 352(1-2)

      Pages: 36-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590144
  • [Journal Article] Regulation of drug absorption from small intestine by enteric nervous system : Studies on passive diffusion2007

    • Author(s)
      T., Kimoto, M., Takanashi, M., Sasaki, K., Ogawara, T., Kimura, K., Higaki
    • Journal Title

      Drug Metab. Rev 39(1)

      Pages: 94-94

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Journal Article] Regulation of P-glycoprotein function by enteric nervous system : Efflux activity and intracellular migration of P-glycoprotein in intestinal epithelial cells2007

    • Author(s)
      H., Mukai, H., Hiraoka, K., Matsushita, K., Ogawara, T., Kimura, K., Higaki
    • Journal Title

      Drug Metab. Rev 39(1)

      Pages: 274-275

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Journal Article] Prediction of oral absorption of griseofulvin, a BCS class II drug, based on GITA model : Utilization of a more suitable medium for in-vitro dissolution study.2007

    • Author(s)
      Y.Fujioka, K.Kadono, Y.Fujie, Y.Metsugi, K.Ogawara, K.Higaki, T.Kimura
    • Journal Title

      J. Control.Rel. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590124
  • [Journal Article] Upregulation of P-glycoprotein expression in small intestine under chronic serotonin-depleted conditions in rats.2005

    • Author(s)
      H.Hiraoka, H.Kimura, Y.furukawa, K.Ogawara, T.Kimura, K.Higaki
    • Journal Title

      J.Pharmacol.Exp.Ther. 312(1)

      Pages: 248-255

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590110
  • [Journal Article] Pharmacokinetic analysis of in-vivo dissolution and absorption behavior of poorly water-soluble drugs after oral administration.2005

    • Author(s)
      Y.Fujioka, K.Kadono, Y.Fujie, Y.Metsugi, K.Ogawara, K.Higaki, T.Kimura
    • Journal Title

      DrugMetab. Rev. 37 (supp. 2)

      Pages: 399-400

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590124
  • [Journal Article] Regulation of drug transport via P-glycoprotein by enteric nervous system.2005

    • Author(s)
      H.Hiraoka, H.Mukai, Matsushita, K.Ogawara, T.Kimura, K.Higaki
    • Journal Title

      Drug Metab.Rev. 37(suppl 2)

      Pages: 79-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590110
  • [Journal Article] Regulation of drug absorption from small intestine by enteric nervous system : Studies on transport via PepT1 and passive diffusion.2005

    • Author(s)
      T.Kimoto, Y.Furukawa, K.Ogawara, T.Kimura, K.Higaki
    • Journal Title

      Drug Metab.Rev. 37(suppl 2)

      Pages: 291-291

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590110
  • [Journal Article] Regulation of drug absorption from small intestine by enteric nervous system I : a poorly absorbable drug via passive diffusion.2004

    • Author(s)
      Kazutaka Higaki
    • Journal Title

      Drug metabolism and Pharmacokinetics 19・3

      Pages: 198-205

    • NAID

      80016771596

    • Data Source
      KAKENHI-PROJECT-16590110
  • [Journal Article] Regulation of drug absorption from small intestine by enteric nervous system I : a poorly absorbable drug via passive diffusion.2004

    • Author(s)
      K.Higaki, M.Sone, K.Ogawara, T.Kimura
    • Journal Title

      Drug Metab.Pharmacokinet. 19(3)

      Pages: 198-205

    • NAID

      80016771596

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590110
  • [Journal Article] Regulation of drug absorption from small intestine by enteric nervous system I : a poorly absorbable drug via passive diffusion2004

    • Author(s)
      K.Higaki
    • Journal Title

      Drug Metab. Pharmacokinet. 19(3)

      Pages: 198-205

    • NAID

      80016771596

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590110
  • [Presentation] マウス乳がん4T1細胞より樹立したがん幹細胞様細胞の特性解析2023

    • Author(s)
      丸山 正人、瀬口 実穂、吉富 健人、檜垣 和孝
    • Organizer
      第39回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K06211
  • [Presentation] マウス乳がん由来4T1細胞におけるがん幹細胞様のモデル細胞株樹立に関する研究2022

    • Author(s)
      瀬口 実穂、丸山 正人、檜垣 和孝
    • Organizer
      第38回 日本DDS学会
    • Data Source
      KAKENHI-PROJECT-20K07155
  • [Presentation] マウス乳がん由来4T1細胞におけるがん幹細胞様のモデル細胞株樹立に関する研究2022

    • Author(s)
      瀬口 実穂、丸山 正人、檜垣 和孝
    • Organizer
      第38回日本DDS学会
    • Data Source
      KAKENHI-PROJECT-20K07155
  • [Presentation] パクリタキセル内封リポソーム製剤の転移性乳がんモデルマウスにおける抗腫瘍効果に及ぼす血管正常化の影響2020

    • Author(s)
      松井 はづき、髙杉 裕太、大河原 賢一、丸山 正人、檜垣 和孝
    • Organizer
      第35回日本薬剤学会
    • Data Source
      KAKENHI-PROJECT-18K06784
  • [Presentation] ドキソルビシン内封リポソーム製剤の悪性黒色腫固形がん治療に及ぼす薬物放出特性の影響2020

    • Author(s)
      家中 悠輔、東條 遥佳、兵頭 健治、石原 比呂之、菊池  寛、大河原 賢一、丸山 正人、檜垣 和孝
    • Organizer
      第35回日本薬剤学会
    • Data Source
      KAKENHI-PROJECT-18K06784
  • [Presentation] 難水溶性-難脂溶性薬物のSelf-nanoemulsifying Drug Delivery System(SNEDDS)製剤化に関する基礎的研究2019

    • Author(s)
      住元 祐介、大川 慎也、大河原 賢一、檜垣 和孝
    • Organizer
      第34回日本薬剤学会
    • Data Source
      KAKENHI-PROJECT-18K06784
  • [Presentation] 光増感剤内封ポリマーナノ粒子製剤を用いた光線力学療法の抗腫瘍効果に及ぼす血管新生阻害剤前投与の影響2019

    • Author(s)
      中野 晶、檜垣 和孝、大河原 賢一
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18K06784
  • [Presentation] パクリタキセル内封微粒子製剤の抗腫瘍効果に及ぼす血管新生阻害剤との併用効果に関する基礎的研究2016

    • Author(s)
      寺内 克、荒川 奏江、大河原 賢一、檜垣 和孝
    • Organizer
      第31回日本薬剤学会
    • Place of Presentation
      長良川国際会議場、岐阜
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-15K08072
  • [Presentation] パクリタキセル内封微粒子製剤の抗腫瘍効果に及ぼす血管新生阻害剤との併用効果に関する基礎的研究2016

    • Author(s)
      寺内 克、荒川 奏江、大河原 賢一、檜垣 和孝
    • Organizer
      第32回日本DDS学会
    • Place of Presentation
      グランシップ、静岡
    • Year and Date
      2016-06-30
    • Data Source
      KAKENHI-PROJECT-15K08072
  • [Presentation] セロトニン症候群発症時における薬物の経口吸収挙動に関する基礎的検討2014

    • Author(s)
      坡山幸恵、中島 駿、大河原 賢一、檜垣 和孝
    • Organizer
      日本薬剤学会第29年会
    • Place of Presentation
      ソニックシティ(さいたま市)
    • Data Source
      KAKENHI-PROJECT-23590181
  • [Presentation] セロトニン症候群発症時における薬物の経口吸収挙動に関する基礎的研究2012

    • Author(s)
      中島駿、岩本武晴、高梨雅史、大河原賢一、木村聰城郎、檜垣和孝
    • Organizer
      日本薬剤学会第27年会
    • Place of Presentation
      神戸国際会議場,神戸
    • Data Source
      KAKENHI-PROJECT-23590181
  • [Presentation] ナノDDS製剤を用いたがん治療の最適化:敵を知ることの重要性2012

    • Author(s)
      大河原 賢一、檜垣 和孝
    • Organizer
      創剤フォーラム第18回若手研究会
    • Place of Presentation
      徳島大学薬学部長井記念ホール
    • Invited
    • Data Source
      KAKENHI-PROJECT-24590194
  • [Presentation] 有機アニオン性化合物の経口吸収挙動に及ぼすセロトニン枯渇の影響2011

    • Author(s)
      三木 朋子、橋本 賢太、大河原 賢一、木村 聰城郎、檜垣 和孝
    • Organizer
      日本薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀, 東京
    • Data Source
      KAKENHI-PROJECT-23590181
  • [Presentation] 有機アニオン性化合物の経口吸収挙動に及ぼすセロトニン枯渇の影響2011

    • Author(s)
      三木朋子、橋本賢太、大河原賢一、木村聰城郎、檜垣和孝
    • Organizer
      日本薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀,東京
    • Data Source
      KAKENHI-PROJECT-23590181
  • [Presentation] Prediction of oral bioavailability of drugs based on Gastro-intestinal-transit absorption(GITA) model2010

    • Author(s)
      Kazutaka Higaki
    • Organizer
      FIP Pharmaceutical Sciences 2010 World Congress(4th PSWC)
    • Place of Presentation
      New Orleans, LA, USA
    • Data Source
      KAKENHI-PROJECT-21590158
  • [Presentation] Importance of gastro-intestinal transit for oral medication2009

    • Author(s)
      K.Higaki
    • Organizer
      ドイツ薬学会 2009年会(Jahrestagung der DphG 2009)
    • Place of Presentation
      Friedrich-Schiller-Universitata Jena, Deutshland
    • Data Source
      KAKENHI-PROJECT-21590158
  • [Presentation] Importance of gastro-intestinal transit for oral medication2009

    • Author(s)
      Kazutaka Higaki
    • Organizer
      Annual conference of the German Pharmaceutical Society 2009
    • Place of Presentation
      Germany
    • Data Source
      KAKENHI-PROJECT-21590158
  • [Presentation] Self-microemulsifying drug delivery system (SMEDDS) による難溶解性薬物の吸収挙動の改善2008

    • Author(s)
      檜垣和孝
    • Organizer
      第14回創剤フォーラム若手研究会
    • Place of Presentation
      岡山大学薬学部
    • Year and Date
      2008-12-13
    • Data Source
      KAKENHI-PROJECT-19590144
  • [Presentation] Self-microemulsifying drug delivery system(SMEDDS)による難溶解性薬物の吸収挙動の改善2008

    • Author(s)
      檜垣和孝
    • Organizer
      第14回創剤フォーラム若手研究会
    • Place of Presentation
      岡山大学薬学部
    • Year and Date
      2008-12-13
    • Data Source
      KAKENHI-PROJECT-19590144
  • [Presentation] Improvement of oral absorption behavior of griseofulvin, a BCS class II drug, by SMEDDS and prediction of absorption kinetics based on GITA model2007

    • Author(s)
      K. Higaki
    • Organizer
      4^<th> World conference on drugabsorption, transport and delivery
    • Place of Presentation
      金沢エクセルホテル東急
    • Data Source
      KAKENHI-PROJECT-19590144
  • [Presentation] Regulation of Drug Absorption from Small Intestine by Enteric Nervous System : Studies on Passive Diffusion2007

    • Author(s)
      Takahiro, Kimoto, Masashi, Takanashi, Moeko, Sasaki, Ken-ichi Ogawara, Toshikiro, Kimura, Kazutaka, Higaki
    • Organizer
      8th International ISSX Meeting
    • Place of Presentation
      Sendai International Center, Sendai, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Presentation] Regulation of P-glycoprotein Function by Enteric Nervous System : Efflux Activity and Intracellular Migration of P-glycoprotein in Intestinal Epithelial Cells2007

    • Author(s)
      Hironori, Mukai, Hideo, Hiraoka, Kotaro, Matsushita, Kenichi, Ogawara, Toshikiro, Kimura, Kazutaka, Higaki
    • Organizer
      8th International ISSX Meeting
    • Place of Presentation
      Sendai International Center, Sendai, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Presentation] Regulation of drug absorption from small intestine by enteric nervous system : Studies on passive diffusion and P-gp function2007

    • Author(s)
      Takahiro, Kimoto, Hideo, Hiraoka, Hironori, Mukai, Moeko, Sasaki, Kenichi, Ogawara, Toshikiro, Kimura, Kazutaka, Higaki
    • Organizer
      4th Pharmaceutical Sciences World Congress
    • Place of Presentation
      RAI Congress Center, Amsterdam, Netherlands
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Presentation] Improvement of oral absorption behavior of griseofulvin, a BCS class II drug, by SMEDDS and prediction of absorption kinetics based on GITA model2007

    • Author(s)
      K. Higaki
    • Organizer
      4th World Conference on Drug Absorption, Transport and Delivery
    • Place of Presentation
      Kanazawa Excel Hotel Tokyu, Kanazawa
    • Data Source
      KAKENHI-PROJECT-19590144
  • [Presentation] Regulation of drug transport via P-glycoprotein by enteric nervous system in Caco-2 monolayers2006

    • Author(s)
      Hironori, Mukai, Hideo, Hiraoka, Kotaro, Matsushita, Kenichi, Ogawara, Toshikiro,Kimura, Kazutaka, Higaki
    • Organizer
      21st Japanese Society for the Study of Xenobiotics Annual Meeting
    • Place of Presentation
      Tower Hall Funabori, Tokyo, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Presentation] Regulation of drug absorption via passive diffusion from small intestine by enteric nervous system2006

    • Author(s)
      Takahiro, Kimoto, Moeko, Sasaki, Ken-ichi, Ogawara, Toshikiro, Kimura, Kazutaka, Higaki
    • Organizer
      21st Japanese Society for the Study of Xenobiotics Annual Meeting
    • Place of Presentation
      Tower Hall Funabori, Tokyo, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590142
  • [Presentation] セロトニン症候群発症時における薬物の経口吸収挙動に関する基礎的検討

    • Author(s)
      坡山幸恵、中島駿、大河原賢一、檜垣和孝
    • Organizer
      日本薬剤学会第29年会
    • Place of Presentation
      ソニックシティ(さいたま市)
    • Year and Date
      2014-05-20 – 2014-05-22
    • Data Source
      KAKENHI-PROJECT-26460197
  • [Presentation] パクリタキセル内封微粒子製剤の抗腫瘍効果に及ぼす血管新生阻害剤との併用効果に関する基礎的研究

    • Author(s)
      荒川 奏江、石川 啓輔、大河原 賢一、檜垣 和孝
    • Organizer
      第29回日本薬剤学会
    • Place of Presentation
      大宮ソニックビル
    • Year and Date
      2014-05-20 – 2014-05-22
    • Data Source
      KAKENHI-PROJECT-24590194
  • [Presentation] Augmented EPR effect by photo-triggered tumor vascular treatment improved therapeutic efficacy of liposomal paclitaxel in mice bearing tumors with low permeable vasculature

    • Author(s)
      Ken-ichi Ogawara, Tomoya Araki, Rie Kawai, Haruka Suzuki, Kazutaka Higaki
    • Organizer
      第8回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      熊本大学薬学部
    • Year and Date
      2014-11-15 – 2014-11-16
    • Data Source
      KAKENHI-PROJECT-24590194
  • [Presentation] 光線力学的前処置が及ぼす腫瘍内血管透過性及びパクリタキセル内封PEGリポソーム製剤の抗腫瘍効果への影響

    • Author(s)
      荒木 知哉、大河原 賢一、檜垣 和孝
    • Organizer
      第135回日本薬学会
    • Place of Presentation
      神戸学院大学など
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-24590194
  • 1.  OOGAWARA Kenichi (30291470)
    # of Collaborated Projects: 18 results
    # of Collaborated Products: 38 results
  • 2.  KIMURA Toshikiro (10025710)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 22 results
  • 3.  KAWAI Keiichi (30204663)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  Maruyama Masato (00399445)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 7 results
  • 5.  TAKAYAMA Fusako (10236367)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  合葉 哲也 (00231754)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  古田 和幸 (50644936)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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