TAKEUCHI YASUO 竹内康雄

… Alternative Names

TAKEUCHI Yasuo 竹内康雄

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Researcher Number	60286359
Affiliation (Current)	2025: 北里大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2015 – 2021: 北里大学, 医学部, 教授 2014: 北里大学, 医学部, 准教授 2011 – 2012: 北里大学, 医学部, 講師 2010: 東京大学, 医科学研究所, 特任研究員 2007 – 2009: 北里大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Collagenous pathology/Allergology / Experimental pathology Except Principal Investigator Collagenous pathology/Allergology / 膠原病・アレルギー・感染症内科学 / Hematology / Urology
Keywords	Principal Investigator プログラム細胞死 / NETosis / 好中球 / 慢性肉芽腫症 / 間質性腎炎 / 機能特異的マクロファージ / 線維化 / ネトーシス / 組織特異的マクロファージ / マクロファージ … More / Apoptosis / 制御性細胞死 / 活性酸素 / 自己抗原提示 / NADPH酵素複合体 / 好中球Netosis / siRNA / p40phox / 好中球活性酸素 / 全身性エリテマトーデス / 細胞内アダプター蛋白 / 骨髄造血幹前駆細胞移植 / Lnk遺伝子 / 遺伝子治療モデル / 遺伝子導入ウイルス / プラム色素マーカー遺伝子 / 移植前処置軽減 / 幹細胞増殖能制御 / Lnk 蛋白 / 造血幹細胞移植 / 遺伝子導入 / 骨髄キメリズム / Lnk 遺伝子変異体 / 遺伝子治療 / 造血幹細胞 … More Except Principal Investigator 好中球 / プログラム細胞死 / 全身性エリテマトーデス / 好中球NETosis / ミトコンドリア / Apoptosis / NETosis / 慢性肉芽腫症 / 制御性細胞死 / SLE / 骨髄混合キメラ / 濾胞樹状細胞 / 骨髄移植 / 全身性ループスエリテマトーデス / 細胞老化 / 発現調節 / レンチウイルスベクター / レトロウイルスベクター / 造血幹細胞 / プロテーオム解析 / プロテオーム解析 / 血中抗体 / 腎移植 Less

The unbalance between post-inflammatory apoptosis and NETosis possibly effects on the phagocyte which accelerate interstitial fibrosis in kidneyPrincipal Investigator
- Principal Investigator
  
  Takeuchi Yasuo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Kitasato University
NETs including oxidative mitochondria DNA might make worse the autoimmune-inflammation in CGD
- Principal Investigator
  
  Takeuchi Emiko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kitasato University
The possibility that suppression of NETosis contributes to improvement of SLEPrincipal Investigator
- Principal Investigator
  
  Takeuchi Yasuo
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kitasato University
The induction of allogenic bone marrow chimerism regulates some lineage of auto-reactive lymphocite, but not all of them in lupus prone mice.
- Principal Investigator
  
  Takeuchi Emiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kitasato University
Human gene therapy model by induction of stable bone marrow chimerim with regulation of proliferative ability of hematopoietic stem cellPrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Yasuo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kitasato University
  The University of Tokyo
In vivo Regulation of the Cell Fates Utilizing a Novel Inducible System of Protein Expression
- Principal Investigator
  
  OTSU Makoto
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Proteomics approach to discover biomarker for kidney transplant rejection
- Principal Investigator
  
  YOSHIDA Kazunari
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kitasato University

All 2021 2020 2019 2018 2017 2016 2015 2014 2012 2009 Other

All Journal Article Presentation

[Journal Article] Inhibitory function of NKT cells during early induction phase of nickel allergy.2016
- Author(s)
  Hironori Okuno, Masashi Satoh, Emiko Takeuchi, Koji Eshima, Masazumi Terashima, Jun Komotori, Sonoko Habu, Hidekazu Tamauchi, Kazuya Iwabuchi.
- Journal Title
  
  Immunobiology
  
  Volume: in press Issue: 7 Pages: 833-838
- DOI
  10.1016/j.imbio.2016.01.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591469, KAKENHI-PROJECT-25460502, KAKENHI-PROJECT-25870708, KAKENHI-PROJECT-26430120, KAKENHI-PROJECT-16K21347
[Journal Article] A possible clue for the production of anti-glomerular basement membrane antibody associated with ureteral obstruction and hydronephritis.2015
- Author(s)
  Takeuchi Y, Takeuchi E, Kamata K.
- Journal Title
  
  Case Rep Nephrol Dial
  
  Volume: 5 Issue: 1 Pages: 87-95
- DOI
  10.1159/000381396
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591469
[Journal Article] Curative haploidentical BMT in a murine model of X-linked chronic granulomatous disease.2015
- Author(s)
  Takeuchi Y, Takeuchi E, Ishida T, Onodera M, Nakauchi H, Ohtsu M.
- Journal Title
  
  Int J Hematol
  
  Volume: 102(1) Issue: 1 Pages: 111-120
- DOI
  10.1007/s12185-015-1799-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591469, KAKENHI-PROJECT-15K15402
[Journal Article] 主要組織適合抗原不一致ドナーからの臍帯血移植による慢性肉芽腫症モデルマウスの治療2015
- Author(s)
  田村昌也、竹内恵美子.
- Journal Title
  
  北里医学
  
  Volume: 45(1) Pages: 53-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591469
[Journal Article] Covenient Evaluation of Magnitude of Glomerulonephritis in BXSB/Mp Lupus Mice.2014
- Author(s)
  Takeuchi E, Iizuka M, Tamura M, Takeuchi Y.
- Journal Title
  
  J Clin Cell Immunol
  
  Volume: 5 Issue: 02 Pages: 209-209
- DOI
  10.4172/2155-9899.1000209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591469
[Journal Article] Dysfunction of selective suppression of auto-antibody production in SLE mouse and reconstruction of this mechanism by induction of bone-marrow chimerism2012
- Author(s)
  Emiko TAKEUCHI, Yasuo TAKEUCHI
- Journal Title
  
  Journal of Transplantation Technology and Research
  
  Volume: IN THE PRESS
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591469
[Presentation] U1 RNP can induce NETosis to isolated mouse neutrophils through NOX2 independent pathway.2021
- Author(s)
  竹内恵美子・大津　真・竹内康雄
- Organizer
  第50回　日本免疫学会
- Data Source
  KAKENHI-PROJECT-18K08217
[Presentation] X連鎖性慢性肉芽腫症モデルgp91phoxknock-out mouseへの肉芽腫形成誘導とNOX2依存的細胞死の関連について2020
- Author(s)
  竹内恵美子・竹内康雄・大津真
- Organizer
  第48回臨床免疫学会
- Data Source
  KAKENHI-PROJECT-18K08217
[Presentation] X連鎖性慢性肉芽腫症モデルgp91phoxknock-out mouseへの肉芽腫形成誘導とNOX2依存的細胞死の関連について．2020
- Author(s)
  竹内恵美子・竹内康雄・大津　真
- Organizer
  第48回臨床免疫学会
- Data Source
  KAKENHI-PROJECT-17K10006
[Presentation] The association between calcium influx and NETosis induced through the NADPH oxidase independent pathway2019
- Author(s)
  Emiko Takeuchi
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-17K10006
[Presentation] In vitroにおけるマウス好中球のNETosis誘導と細胞外カルシウム濃度の関係について2019
- Author(s)
  竹内恵美子、竹内康雄
- Organizer
  第47回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-18K08217
[Presentation] The association between calcium influx and NETosis induced through the NADPH oxidase independent pathway2019
- Author(s)
  EMIKO Takeuchi、YASUO Takeuchi, KAZUYA Iwabuchi
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-18K08217
[Presentation] In vitroにおけるマウス好中球のNetosis誘導と細胞外カルシウム濃度の関係について2019
- Author(s)
  竹内恵美子
- Organizer
  第47回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-17K10006
[Presentation] NADPH oxidase (NOX2)非依存的好中球NETosis誘導とミトコンドリアROS産生の関連について2018
- Author(s)
  竹内恵美子　竹内康雄
- Organizer
  第46回　臨床免疫学会
- Data Source
  KAKENHI-PROJECT-17K10006
[Presentation] NADPH oxidase(NOX2)非依存的好中球Netosis誘導とミトコンドリアROS産生の関連について2018
- Author(s)
  竹内恵美子　竹内康雄
- Organizer
  第46回　臨床免疫学会
- Data Source
  KAKENHI-PROJECT-18K08217
[Presentation] The association NADPH oxidase independent NETosis with acceleration of mitochondrial ROS production2018
- Author(s)
  Emiko Takeuchi, Yasuo Takeuchi, Kazuya Iwabuchi
- Organizer
  The 47th Annual meeting of the japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08217
[Presentation] The association NADPH oxidase independent NETosis with acceleration of mitochondrial ROS production2018
- Author(s)
  Emiko Takeuchi,　Yasuo Takuchi, Kazuya Iwabuchi
- Organizer
  The 47th Annual meeting of The Japanese Society for Immunolgy
- Data Source
  KAKENHI-PROJECT-17K10006
[Presentation] .Quantitative analysis of Neutrophil extracellular traps (NETs) in lupus prone mouse using novel methods2017
- Author(s)
  Shin Morisawa、Emiko Takeuchi, Yauso Takeuchi
- Organizer
  The 46th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-26461490
[Presentation] .LupusモデルマウスBXSBを用いた好中球NETosisの新たな定量と定性解析2017
- Author(s)
  竹内恵美子、森澤慎、竹内康雄
- Organizer
  第45回　日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-26461490
[Presentation] Quantitative analysis of Neutrophil extracellular traps (NETs) in lupus prone mouse using novel methods．2017
- Author(s)
  Shin Morisawa、Emiko Takeuchi, Yauso Takeuchi
- Organizer
  The 46th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-17K10006
[Presentation] LupusモデルマウスBXSBを用いた好中球NETosisの新たな定量と定性解析.2017
- Author(s)
  竹内恵美子、森澤慎、竹内康雄
- Organizer
  第45回　臨床免疫学会
- Data Source
  KAKENHI-PROJECT-17K10006
[Presentation] 活性酸素はアリストロキアサンによる急性腎障害進行を抑制する2015
- Author(s)
  竹内康雄、竹内恵美子、鎌田貢壽、河原克雅
- Organizer
  第58回　日本腎臓学会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-24591469
[Presentation] 慢性肉芽腫症モデルマウスにおいてアリストロキア酸誘導性尿細管壊死性腎炎が増悪するメカニズムの解析.2015
- Author(s)
  竹内恵美子、竹内康雄
- Organizer
  第43回　臨床免疫学会
- Place of Presentation
  神戸国際会議場(兵庫県神戸市)
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-24591469
[Presentation] 多様自己抗体陽性の免疫調節異常１症乳児例.2014
- Author(s)
  緒方昌平、竹内恵美子、野元けい子、扇原義人、江波戸孝輔、紺野寿、坂東由紀、高木正稔、石井正浩
- Organizer
  第５回関東甲信越免疫不全症研究会
- Place of Presentation
  東京都千代田区
- Year and Date
  2014-09-21
- Data Source
  KAKENHI-PROJECT-24591469
[Presentation] Development of experimental animal model of human gene therapy for X-CGD2012
- Author(s)
  Takeuchi Y, Amirhosseini M, Franklin L, Takeuchi E, Nakauchi H, Otsu M
- Organizer
  第38回ヨーロッパ骨髄移植会議
- Place of Presentation
  Geneva, Switzerland
- Data Source
  KAKENHI-PROJECT-22590355
[Presentation] Development of experimental animal model of human gene therapy for X-CGD2012
- Author(s)
  Yasuo Takeuchi
- Organizer
  第３８回ヨーロッパ骨髄移植会議
- Place of Presentation
  Geneva, Swiss
- Data Source
  KAKENHI-PROJECT-22590355
[Presentation] Dysfunction of selective suppression of auto-antibody production in SLE mice and reconstruction of this mechanism by induction of bone-marrow chimerism.2012
- Author(s)
  Emiko TAKEUCHI, Yasuo TAKEUCHI, Nobukata SHINOHARA, Kazuya IWABUCHI
- Organizer
  日本免疫学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24591469
[Presentation] A threshold in expression levels of gp91phox transgene limits the degree of functional correction in granulocytes after gene therapy for CGD.2009
- Author(s)
  竹内康雄, 他
- Organizer
  The 17^<th> Annual Congress of the ESGCT
- Place of Presentation
  Hannover, Germany
- Data Source
  KAKENHI-PROJECT-21591231
[Presentation] 抗CD40Lモノクローナル抗体投与を用いた骨髄混合キメリズム誘導による慢性肉芽腫症モデルマウスの治療2009
- Author(s)
  竹内康雄, 他
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21591231
[Presentation] Stable supply of functional reconstituted neutrophils achieved by transplantation of allogeneic umbilical cord blood induced remission of inflammatory state in X-CGD mice.
- Author(s)
  E Takeuchi, Y Takeuchi
- Organizer
  18th European society of gene and cell therapy.
- Place of Presentation
  Hague, Netherland.
- Year and Date
  2014-10-23 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-24591469
[Presentation] MHC不一致ドナーからの臍帯血移植による慢性肉芽腫症モデルマウスの治療.
- Author(s)
  竹内恵美子、田村昌也、竹内康雄
- Organizer
  第42回　日本臨床免疫学会
- Place of Presentation
  東京都新宿区
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24591469
[Presentation] Development of experimental animal model to assess of cause for disappearance of gene-corrected granulocytes as a clinical problem of human gene therapy of X-CGD
- Author(s)
  Takeuchi Y, Takeuchi E, Otsu S
- Organizer
  European Academy of Allergy and Clinical Immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-24591469
[Presentation] Characterization of non-invariant NKT cells in visceral adipose tissue.
- Author(s)
  Satoh M, Eshima K, Takeuchi E, Iwabuchi K.
- Organizer
  Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Makuhari, Japan
- Data Source
  KAKENHI-PROJECT-24591469
[Presentation] Development of gene therapy model for disappearance of gene-corrected granulocytes by immunological deletion associated with antigenicity of newly expressed GP91phox protein in X-CGD.
- Author(s)
  Takeuchi Y, Takeuchi E, Otsu S
- Organizer
  Controversies in Rheumatorogy and Autoimmunity
- Place of Presentation
  Budapest, Hungary.
- Data Source
  KAKENHI-PROJECT-24591469
[Presentation] The role of immunocompetent cells in the development of nickel-induced allergic contact dermatitis
- Author(s)
  Okuno H, Satoh M, Takeuchi E, Eshima K, Tamauchi H, Iwabuchi K
- Organizer
  Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Makuhari, Japan
- Data Source
  KAKENHI-PROJECT-24591469

1. OTSU Makoto (30361330)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. Takeuchi Emiko (00406935)

# of Collaborated Projects: 4 results

# of Collaborated Products: 31 results
3. YOSHIDA Kazunari (10174921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. OISHI Masamichi (40233027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KODERA Yoshio (60265733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. BABA Shiro (00051889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OKUSA Hiroshi (70337963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MAEDA Tadakazu (90265728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MURAMOTO Masatoshi (50265633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. IWABUCHI Kazuya (20184898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. 川島永子 (90342774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKEUCHI YASUO 竹内 康雄

TAKEUCHI Yasuo 竹内 康雄

Research Projects

Research Products

Co-Researchers

The unbalance between post-inflammatory apoptosis and NETosis possibly effects on the phagocyte which accelerate interstitial fibrosis in kidneyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

NETs including oxidative mitochondria DNA might make worse the autoimmune-inflammation in CGD

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The possibility that suppression of NETosis contributes to improvement of SLEPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The induction of allogenic bone marrow chimerism regulates some lineage of auto-reactive lymphocite, but not all of them in lupus prone mice.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Human gene therapy model by induction of stable bone marrow chimerim with regulation of proliferative ability of hematopoietic stem cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In vivo Regulation of the Cell Fates Utilizing a Novel Inducible System of Protein Expression

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proteomics approach to discover biomarker for kidney transplant rejection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Inhibitory function of NKT cells during early induction phase of nickel allergy.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A possible clue for the production of anti-glomerular basement membrane antibody associated with ureteral obstruction and hydronephritis.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Curative haploidentical BMT in a murine model of X-linked chronic granulomatous disease.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 主要組織適合抗原不一致ドナーからの臍帯血移植による慢性肉芽腫症モデルマウスの治療2015

Author(s)

Journal Title

Data Source

[Journal Article] Covenient Evaluation of Magnitude of Glomerulonephritis in BXSB/Mp Lupus Mice.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dysfunction of selective suppression of auto-antibody production in SLE mouse and reconstruction of this mechanism by induction of bone-marrow chimerism2012

Author(s)

Journal Title

Data Source

[Presentation] U1 RNP can induce NETosis to isolated mouse neutrophils through NOX2 independent pathway.2021

Author(s)

Organizer

Data Source

[Presentation] X連鎖性慢性肉芽腫症モデルgp91phoxknock-out mouseへの肉芽腫形成誘導とNOX2依存的細胞死の関連について2020

TAKEUCHI YASUO 竹内康雄

TAKEUCHI Yasuo 竹内康雄