SHIMIZU Jun 清水淳

Researcher Number	60291134
Other IDs
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Affiliation (based on the past Project Information) *help	2008: Kyoto University, 医学研究科, 准教授 2007: National Institute for Longevity Sciences,NCGG, 老化機構研究部, 室長 2006: 国立長寿医療センター, (研究所)・老化機構研究部, 室長 2005: 国立長寿医療センター, (研究所)・老化機構研究部・免疫研究室, 室長 2005: National Institute for Longevity Sciences, Section of Immunology, Department of Mechanism of Aging, Section Chief, (研究所)・老化機構研究部免疫研究室, 室長 … More 2004: 財団法人東京都高齢者研究, 福祉振興財団・東京都老人総合研究所, 研究員 2003: (財)東京都高齢者研究・福祉振興財団, 東京都老人総合研究所・免疫学的老化研究グループ, 主任研究員 2000: (財)東京都老人総合研究所, 免疫病理, 研究員 2000: TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY, DEPARTMENT OF IMMUNOPATHOLOGY, RESEARCH SCIENTIST, 免疫病理部門, 研究員 1999: 財団法人東京都老人総合研究所, 免疫病理, 研究員 1998: 財団法人東京都老人総合研究所, 免疫病理部門, 研究員 1997: (財)東京都老人総合研究所, 免疫病理部門, 研究員 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Biological Sciences / Experimental pathology / Immunology Except Principal Investigator Experimental pathology
Keywords	Principal Investigator 老化 / CD4T細胞 / 免疫抑制 / CD25^+T細胞 / Immunoregulation / CD4 T cells / Aging / ANERGY / TUMOR IMMUNOLOGY / CD25^+ T CELLS … More / アナージー / アナージ / 腫瘍免疫 / T細胞 / 免疫 / 細胞 / 抗体 / I型糖尿病 / 膵島炎 / NODマウス / 自己免疫 … More Except Principal Investigator 免疫制御 / トランスジェニックマウス / T細胞 / T細胞性制御 / 免疫的自己寛容 / 自己免疫病 Less

Functional analysis of CD4 T cell-subpopulation exhibiting low responsiveness in aged hostsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Jun
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyoto University
  National Institute for Longevity Sciences,NCGG
老齢マウス由来免疫抑制性CD4T細胞の抑制機構解析Principal Investigator
- Principal Investigator
  
  清水淳
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
免疫抑制性CD4T細胞の抑制機能を阻害する新規抗体を用いた免疫応答の操作Principal Investigator
- Principal Investigator
  
  清水淳
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
Cross-linking of CD45 on suppressive/regulatory T cells leads to the abrogation of their suppressive activity in vitroPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Jun
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  National Institute for Longevity Sciences
  Tokyo Metropolitan Institute of Gerontology
BREAKING IMMUNOLOGICAL TOLERANCE TO TUMOR CELLS AS A NOVEL IMMUNOTHERAPY FOR CANCERPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Jun
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY
T細胞亜集団の操作による自己免疫病の誘導と自己寛容維持機構の解析Principal Investigator
- Principal Investigator
  
  清水淳
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology
発生工学的手法による自己免疫病発症機構の解析
- Principal Investigator
  
  SAKAGUCHI Shimon
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute of Gerontology

All 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Book

[Book] 坂口志文分子リウマチ2007
- Author(s)
  清水淳
- Publisher
  GITRL / GITR のCD4T細胞機能への作用
- Data Source
  KAKENHI-PROJECT-18390127
[Book] 高齢個体の免疫2007
- Author(s)
  西岡朋尚、清水淳
- Publisher
  臨床免疫・アレルギー科
- Data Source
  KAKENHI-PROJECT-18390127
[Book] CD4T細胞の加齢変化2007
- Author(s)
  西岡朋尚、清水淳
- Publisher
  臨床免疫・アレルギー科
- Data Source
  KAKENHI-PROJECT-18390127
[Journal Article] In vivo expansion of CD4^+Foxp3^+ regulatory T cells mediated by GITR molecules.2008
- Author(s)
  Nishioka T, Nishida E, Iida R, Morita A, Shimizu J
- Journal Title
  
  Immunol Lett 121
  
  Pages: 97-104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390127
[Journal Article] Antigen-independent generation of a unique CD4 T cell-subset with aging and its persistent unresponsiveness2008
- Author(s)
  Nishida E, Nishioka T, Iida R, Yagita H, Morita A, Shimizu J
- Journal Title
  
  Immunol Lett 121
  
  Pages: 27-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390127
[Journal Article] TNFファミリー分子の分子リウマチ学:GITRL / GITR.2007
- Author(s)
  清水淳、
- Journal Title
  
  分子リウマチ(先端医学社) 4
  
  Pages: 324-329
- Data Source
  KAKENHI-PROJECT-18390127
[Journal Article] Ohno-Iwashita Y. Impairment in a negative regulatory system for TCR signaling in CD4^+ T cells from old mice2007
- Author(s)
  Inomata M, Shimada Y, Hayashi M, Shimizu J
- Journal Title
  
  FEBS Lett 581
  
  Pages: 3039-3043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390127
[Journal Article] Control of autoimmune myocarditis and multi-organ inflammation by GITRhigh Foxp3-expressing CD25+ and CD25- regulatory T cells2006
- Author(s)
  Ono M, Shimizu J, Miyachi Y, and Sakaguchi S
- Journal Title
  
  J. Immunol 176
  
  Pages: 4748-4756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390127
[Journal Article] Control of Autoimmune Myocarditis and Multiorgan Inflammation by Glucocorticoid-Induced TNF Receptor Family-Related Proteinhigh, Foxp3-Expressing CD25+ and CD25- Regulatory T Cells.2006
- Author(s)
  Ono M, Shimizu J, Miyachi Y, Sakaguchi S.
- Journal Title
  
  J Immunol 176
  
  Pages: 4748-4756
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] Iida R, Yamazaki S, and Sakaguchi S. CD4^+CD25^+Foxp3^+ T cells and CD4^+CD^25-Foxp3^+ T cells in aged mice2006
- Author(s)
  Nishioka T, Shimizu J
- Journal Title
  
  J. Immunol 176
  
  Pages: 6586-6593
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390127
[Journal Article] CD4+CD25+Foxp3+ T Cells and CD4+CD25-Foxp3+ T Cells in Aged Mice.2006
- Author(s)
  Nishioka T, Shimizu J, Iida R, Yamazaki S, Sakaguchi S.
- Journal Title
  
  J Immunol 176
  
  Pages: 6586-6593
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] Foxp3^+CD25^+CD4^+ natural regulatory T cells in dominant self-tolerance and autoimmune disease2006
- Author(s)
  Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fehervari Z, Shimizu J, Takahashi T, Nomura T
- Journal Title
  
  Immunol Rev 212
  
  Pages: 8-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390127
[Journal Article] 加齢と免疫2005
- Author(s)
  清水淳
- Journal Title
  
  生涯教育シリーズ67 日本医師会雑誌特別号「わかりやすい免疫疾患」 (in press)
- Data Source
  KAKENHI-PROJECT-16043262
[Journal Article] The capacity of the natural ligands for CD28 to drive IL-4 expression in naive and antigen-primed CD4+ and CD8+ T cells.2005
- Author(s)
  Bian Y, Hiraoka S, Tomura M, Zhou XY, Yashiro-Ohtani Y, Mori Y, Shimizu J, Ono S, Dunussi-Joannopoulos K, Wolf S, Fujiwara H.
- Journal Title
  
  Int Immunol 17
  
  Pages: 73-83
- NAID
  10014258604
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] Cross-linking of CD45 on suppressive/regulatory T cells leads to the abrogation of their suppressive activity in vitro.2005
- Author(s)
  Shimizu J
- Journal Title
  
  J.Immunol. (in press)
- Data Source
  KAKENHI-PROJECT-16043262
[Journal Article] Cross-linking of CD45 on suppressive/regulatory T cells leads to the abrogation of their suppressive activity in vitro.2005
- Author(s)
  Shimizu J, Iida R, Sato Y, Moriizumi E, Nishikawa A, Ishida Y.
- Journal Title
  
  J Immunol 174
  
  Pages: 4090-4097
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] Cross-linking of CD45 on suppressive/regulatory T cells leads to the abrogation of their suppressive activity in vitro.2005
- Author(s)
  Shimizu, J
- Journal Title
  
  J.Immunol. 174
  
  Pages: 4090-4097
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] 加齢と免疫.「わかりやすい免疫疾患」生涯教育シリーズ672005
- Author(s)
  清水淳
- Journal Title
  
  日本医師会雑誌特別号
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] Cross-linking of CD45 on suppressive/regulatory T cells leads to the abrogation of their suppressive activity in vitro.2005
- Author(s)
  Shimizu J
- Journal Title
  
  J.Immunol. (in press)
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells.2005
- Author(s)
  Ko K, Yamazaki S, Nakamura K, Nishioka T, Hirota K, Yamaguchi T, Shimizu J, Nomura T, Chiba T, Sakaguchi S.
- Journal Title
  
  J Exp Med 202
  
  Pages: 885-891
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] 加齢と免疫「わかりやすい免疫疾患」生涯教育シリーズ672005
- Author(s)
  清水淳
- Journal Title
  
  日本医師会雑誌特別号
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] Cross-linking of CD45 on suppressive/regulatory T cells leads to the abrogation of their suppressive activity in vitro.2005
- Author(s)
  Shimizu, J.
- Journal Title
  
  J.Immunol. 174
  
  Pages: 4090-4097
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] 加齢と免疫2005
- Author(s)
  清水淳
- Journal Title
  
  生涯教育シリーズ67 日本医師会雑誌特別号「わかりやすい免疫疾患」 (in press)
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] 老化に伴う免疫抑制性CD4T細胞の出現2004
- Author(s)
  清水淳
- Journal Title
  
  基礎老化研究 28
  
  Pages: 15-19
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] 老化に伴う免疫抑制性CD4T細胞の出現2004
- Author(s)
  清水淳
- Journal Title
  
  基礎老化研究 28
  
  Pages: 15-19
- Data Source
  KAKENHI-PROJECT-16043262
[Journal Article] 老化に伴う免疫抑制性CD4T細胞の出現2004
- Author(s)
  清水淳
- Journal Title
  
  基礎老化研究 28
  
  Pages: 15-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] Regulation of autoimmune diabetes by non-islet-specific T cells - a role for the glucocorticoid-induced TNF receptor.2004
- Author(s)
  Suri A, Shimizu J, Katz JD, Sakaguchi S, Unanue ER, Kanagawa O.
- Journal Title
  
  Eur J Immunol 34
  
  Pages: 447-454
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] CD4+CD25- T cells in aged mice are hyporesponsive and exhibit suppressive activity.2003
- Author(s)
  Shimizu J, Moriizumi E.
- Journal Title
  
  J Immunol 170
  
  Pages: 1675-1682
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390132
[Journal Article] Aging-dependent generation of suppressive CD4+CD25-R1231oCD103+ T cells in mice.2003
- Author(s)
  Shimizu J, Moriizumi E.
- Journal Title
  
  Eur J Immunol 33
  
  Pages: 2449-2458
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390132
[Presentation] Conversion of CD4^+Foxp3^-T cells into CD^4+Foxp^3+ T cells is inhibited by agonistic anti-GITR antibody2008
- Author(s)
  Nishida E, Nishioka T, Iida R, Morita A, Shimizu J
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-18390127
[Presentation]2007
- Author(s)
  西岡朋尚、西田絵美、清水淳
- Organizer
  第5回21世紀COE 若手研究フォーラムGITR を介する刺激で制御性T 細胞は増殖する
- Place of Presentation
  名古屋大学医学部
- Year and Date
  2007-06-07
- Data Source
  KAKENHI-PROJECT-18390127
[Presentation] 老化と免疫抑制性T細胞2007
- Author(s)
  清水淳
- Organizer
  協和発酵(株)バイオフロンティア研究所セミナー
- Place of Presentation
  東京
- Year and Date
  2007-01-18
- Data Source
  KAKENHI-PROJECT-18390127
[Presentation] In vivo expansion of CD4+Foxp3+ regulatory T cells mediated by GITR molecules2007
- Author(s)
  清水淳
- Organizer
  京都大学再生医科学研究所セミナー
- Place of Presentation
  京都
- Year and Date
  2007-02-23
- Data Source
  KAKENHI-PROJECT-18390127
[Presentation] 制御性CD4T細胞と同様の免疫抑制作用を呈す新規モノクローナル抗体の樹立2007
- Author(s)
  西岡朋尚, 西田絵美, 清水淳
- Organizer
  第37回日本免疫学会総会
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-18390127
[Presentation] In vivo expansion of CD4^+Foxp3^+ regulatory T cells mediated by GITR molecules2007
- Author(s)
  Shimizu J, Nishioka T, and Iida R
- Organizer
  Gordon Research Conferences
- Place of Presentation
  Los Angels
- Year and Date
  2007-03-25
- Data Source
  KAKENHI-PROJECT-18390127
[Presentation] 新規抗GITR抗体による制御性CD4T細胞の増殖誘導2007
- Author(s)
  西田絵美, 西岡朋尚, 森田明理, 清水淳
- Organizer
  第37回日本免疫学会総会
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-18390127
[Presentation] Age-dependent reduction of PAG, a lipid raft-associated transmembrane adaptor protein, in mouse CD4 T cells2006
- Author(s)
  Shimada Y, Inomata M, Hayashi M, Shimizu J, Ohno-Iwashita Y
- Organizer
  20^<th> IUBMB International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  Kyoto
- Year and Date
  2006-06-18
- Data Source
  KAKENHI-PROJECT-18390127
[Presentation] 老化したCD4T 細胞では脂質ラフトを介した「負」のシグナル制御系に異常がある2006
- Author(s)
  猪股光司、嶋田有紀子、林昌美、清水淳、岩下淑子
- Organizer
  第29回日本基礎老化学会
- Place of Presentation
  長崎
- Year and Date
  2006-06-16
- Data Source
  KAKENHI-PROJECT-18390127
[Presentation] 老化と免疫抑制性CD4T細胞2006
- Author(s)
  清水淳
- Organizer
  名古屋市立大学医学部皮膚科セミナー
- Place of Presentation
  名古屋.
- Year and Date
  2006-09-22
- Data Source
  KAKENHI-PROJECT-18390127
[Presentation] 高齢個体の免疫2006
- Author(s)
  清水淳
- Organizer
  第34回日本臨床免疫学会学術集会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2006-10-02
- Data Source
  KAKENHI-PROJECT-18390127
[Presentation] CD4^+CD25^+Foxp3^+ T cells and CD4^+CD25^-Foxp3^+ T cells in aged mice2006
- Author(s)
  Nishioka T, Iida R, and Shimizu J
- Organizer
  The 8^<th> International Congress of Neuroimmunology
- Place of Presentation
  Nagoya
- Year and Date
  2006-10-15
- Data Source
  KAKENHI-PROJECT-18390127
[Presentation] CD45 molecules as a functional modulator of regulatory CD4 T cells2006
- Author(s)
  Shimizu J, Iida R, Nishioka T
- Organizer
  Immunology 2006
- Place of Presentation
  Boston
- Year and Date
  2006-05-15
- Data Source
  KAKENHI-PROJECT-18390127

1. SAKAGUCHI Shimon (30280770)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. NISHIOKA Tomohisa (50419149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
3. 戸田雅昭 (10202201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YAMAZAKI Sayuri

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIMIZU Jun 清水 淳

Research Projects

Research Products

Co-Researchers

Functional analysis of CD4 T cell-subpopulation exhibiting low responsiveness in aged hostsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

老齢マウス由来免疫抑制性CD4T細胞の抑制機構解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

免疫抑制性CD4T細胞の抑制機能を阻害する新規抗体を用いた免疫応答の操作Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cross-linking of CD45 on suppressive/regulatory T cells leads to the abrogation of their suppressive activity in vitroPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

BREAKING IMMUNOLOGICAL TOLERANCE TO TUMOR CELLS AS A NOVEL IMMUNOTHERAPY FOR CANCERPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

T細胞亜集団の操作による自己免疫病の誘導と自己寛容維持機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

発生工学的手法による自己免疫病発症機構の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 坂口志文 分子リウマチ2007

Author(s)

Publisher

Data Source

[Book] 高齢個体の免疫2007

Author(s)

Publisher

Data Source

[Book] CD4T細胞の加齢変化2007

Author(s)

Publisher

Data Source

[Journal Article] In vivo expansion of CD4^+Foxp3^+ regulatory T cells mediated by GITR molecules.2008

Author(s)

Journal Title

Data Source

[Journal Article] Antigen-independent generation of a unique CD4 T cell-subset with aging and its persistent unresponsiveness2008

Author(s)

Journal Title

Data Source

[Journal Article] TNFファミリー分子の分子リウマチ学:GITRL / GITR.2007

Author(s)

Journal Title

Data Source

[Journal Article] Ohno-Iwashita Y. Impairment in a negative regulatory system for TCR signaling in CD4^+ T cells from old mice2007

Author(s)

Journal Title

Data Source

[Journal Article] Control of autoimmune myocarditis and multi-organ inflammation by GITRhigh Foxp3-expressing CD25+ and CD25- regulatory T cells2006

Author(s)

Journal Title

Data Source

[Journal Article] Control of Autoimmune Myocarditis and Multiorgan Inflammation by Glucocorticoid-Induced TNF Receptor Family-Related Proteinhigh, Foxp3-Expressing CD25+ and CD25- Regulatory T Cells.2006

Author(s)

SHIMIZU Jun 清水淳

[Book] 坂口志文分子リウマチ2007