AOYAMA Hiroshi 青山浩

… Alternative Names

青山浩アオヤマヒロシ

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Researcher Number	60291910
Other IDs	https://orcid.org/0000-0001-7915-8975
Affiliation (Current)	2024: 順天堂大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2024: 順天堂大学, 薬学部, 教授 2022: 大阪大学, 大学院薬学研究科, 准教授 2021: 大阪大学, 薬学研究科, 准教授 2016: 大阪大学, 薬学研究科, 准教授 2012 – 2015: 大阪大学, 薬学研究科(研究院), 准教授 … More 2012 – 2013: 大阪大学, 大学院・薬学研究科, 准教授 2011: 大阪大学, 薬学研究所, 准教授 2008 – 2011: 大阪大学, 薬学研究科, 准教授 2010: 大阪大学, 大学院・薬学研究科, 准教授 1997 – 1998: 理化学研究所, 光合成科学研究室, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Structural biochemistry / Biophysics Except Principal Investigator Physical pharmacy
Keywords	Principal Investigator X線結晶構造解析 / 膜タンパク質 / 核酸医薬 / 人工核酸 / 構造生物学 / 構造活性相関 / クライオ電子顕微鏡 / DNAナノテクノロジー / 国際情報交換 / Ｘ線結晶構造解析 … More / リン脂質 / 脂質代謝 / X 線結晶構造解析 / 光化学系II複合体 / 光合成 … More Except Principal Investigator X線結晶構造解析 / 共鳴ラマン分光 / 一塩基多型 / 薬物代謝 / シトクロムP450 / シトクロムＰ４５０ Less

核酸の立体構造解析を加速するパイプラインの構築Principal Investigator
- Principal Investigator
  
  青山浩
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Juntendo University
ホスト-ゲストを利用した二重鎖核酸のX線結晶構造解析Principal Investigator
- Principal Investigator
  
  青山浩
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Osaka University
Studies on molecular mechanism of paracellular pathwayPrincipal Investigator
- Principal Investigator
  
  Aoyama Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Chain Reaction of Drug Metabolism -A Comprehensive Study on the Cooperative and Competitive Drug Metabolism by CYP Isoforms
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
Structural and functional analysis of GDE family proteinsPrincipal Investigator
- Principal Investigator
  
  AOYAMA Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
A Comprehensive Study on the Drug-Drug Interactions in Drug Metabolizing Enzyme CYP
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
酵素発生活性を保持した光化学系II複合体の結晶化とX線構造解析Principal Investigator
- Principal Investigator
  
  青山浩
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  The Institute of Physical and Chemical Research

All 2016 2015 2014 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Engineered Cx26 variants established functional heterotypic Cx26/Cx43 and Cx26/Cx40 gap junction channels2016
- Author(s)
  Levent B. Karademir, Hiroshi Aoyama, Benny Yue, Honghong Chen, Donglin
- Journal Title
  
  Biochemical Journal
  
  Volume: 473 Issue: 10 Pages: 1391-1403
- DOI
  10.1042/bcj20160200
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440029
[Journal Article] Engineered Cx40 variants increased docking and function of heterotypic Cx40/Cx43 gap junction channels2016
- Author(s)
  Arjewan Jassim, Hiroshi Aoyama ,Willy G. Ye, Honghong Chen, Donglin Bai
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 90 Pages: 11-20
- DOI
  10.1016/j.yjmcc.2015.11.026
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440029
[Journal Article] The first extracellular domain plays an important role in unitary channel conductance of Cx50 gap junction channels2015
- Author(s)
  Xiaoling Tong, Hiroshi Aoyama, Swathy Sudhakar, Honghong Chen, Brian H. Shilton, Donglin Bai
- Journal Title
  
  PLOS ONE
  
  Volume: 10(12) Issue: 12 Pages: e0143876-e0143876
- DOI
  10.1371/journal.pone.0143876
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440029
[Journal Article] Charge at the 46th residue of connexin 50 is crucial for the gap-junction unitary conductance and transjunctional voltage-depending gating2014
- Author(s)
  Xiaoling Tong, Hiroshi Aoyama, Tomitake Tsukihara, Donglin Bai
- Journal Title
  
  The Journal of Physiology
  
  Volume: 592 Issue: 23 Pages: 5187-5202
- DOI
  10.1113/jphysiol.2014.280636
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26440029
[Presentation] ENGINEERED CX40 VARIANTS SHOWED HETEROTYPIC COLOCALIZATION AND INCREASED GAP JUNCTIONAL COUPLING WITH CX432016
- Author(s)
  Arjewan Jassim, Hiroshi Aoyama, Willy G. Ye, Honghong Chen, Donglin Bai
- Organizer
  Biophysical Society 60th Annual Meeting
- Place of Presentation
  Los Angeles, USA
- Year and Date
  2016-02-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440029
[Presentation] The first extracellular domain plays an important role in single channel conductance of Cx50 gap junction channels2015
- Author(s)
  Tong, Xiaoling., Aoyama, Hiroshi., Sudhakar, Swathy., Chen, Honghong., Bai, Donglin
- Organizer
  International Gap Junction Conference
- Place of Presentation
  Chile
- Year and Date
  2015-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440029
[Presentation] Effects of Single Nucleotide Polymorphisms (SNPs) on Drug Metabolism in Human CYP2C92012
- Author(s)
  Tadayuki Uno, Yumi Erikawa, Masayoshi Miyamoto, Yuki Yasuhara, Taku Yamashita, Hiroshi Aoyama
- Organizer
  Seventh International Conference on Porphyrins and Phthalocyanines
- Place of Presentation
  Jeju, Korea
- Year and Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Effects of SNPs on the metabolism of Amitriptyline in CYP2D62012
- Author(s)
  宇野公之, 堀井千明, 山田麻由, 上村真司, 青山浩, 山下沢
- Organizer
  第22回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Effects of Single Nucleotide Polymorphisms (SNPs) on the Interaction of Human CYP reductase with CYP2C19 and Its Drug Metabolizing Properties2012
- Author(s)
  宮本正芳, 飯賀由実子, 松本麻希, 安原由樹, 青山浩, 山下沢, 宇野公之
- Organizer
  第22回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] The role of lipid membrane in the course of drug metabolism by cytochrome P4502012
- Author(s)
  宇野公之, 安原由樹, 宮本正芳, 山田麻由, 山下沢, 青山浩
- Organizer
  第22回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Effect of Single Nucleotide Polymorphisms(SNPs) on the Activation of Procarcinogens in Human CYP1A22012
- Author(s)
  Tadayuki Uno, Jun-ichi Node, Sakiko Morita, Akihide Tsujimoto, Taku Yamashita, Hiroshi Aoyama
- Organizer
  Seventh International Conference on Porphyrins and Phthalocyanines
- Place of Presentation
  Jeju, Korea
- Year and Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Three Cytochrome P450s Responsible for the Metabolism of Amitriptyline and Imipramine2011
- Author(s)
  Tadayuki Uno, Mayu Yamada, Shinji Uemura, Sakiko Morita, Maki Matsumoto, Hiroshi Aoyama, Taku Yamashita
- Organizer
  15th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2011-08-08
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] Effect of Single Nucleotide Polymorphisms (SNPs) on the Drug Binding and Metabolizing Properties of Human CYP2C192011
- Author(s)
  Tadayuki Uno, Masayoshi Miyamoto, Yumiko Iiga, Maki Matsumoto, Hiroshi Aoyama, Taku Yamashita
- Organizer
  15th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2011-08-08
- Data Source
  KAKENHI-PROJECT-23390011
[Presentation] SNP variants reveal the crucial region for drug recognition in human CYP2C19 The International Chemical Congress of Pacific Basin Societies2010
- Author(s)
  Maki Matsumoto, Yumiko Iiga, Sayed M.S. Ali, Ryuichi Sasaki, Taku Yamashita, Hiroshi Aoyama, Tadayuki Uno
- Organizer
  Pacifichem2010
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Drug Binding and Metabolizing Properties of Human Cytochrome P450 1A22010
- Author(s)
  宇野公之, 森田早紀子, 辻本景英, 江川真文, 山下沢, 青山浩
- Organizer
  Sixth International Conference on Porphyrins and Phthalocyanines (ICPP-6)
- Place of Presentation
  Santa Ana Pueblo, New Mexico, USA
- Year and Date
  2010-07-06
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Expression and purification of NADPH-cytochrome P450 oxidoreductase2010
- Author(s)
  宇野公之, 宮本正芳, 戸山亮, 松本麻希, 金森美果, 山田麻由, 山下沢, 青山浩
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Proton relay system in human CYP2C9 as revealed by site-directed mutagenesis The International Chemical Congress of Pacific Basin Societies2010
- Author(s)
  金森美果, 大河万顕, 香川雄輔, 山下沢, 青山浩, 宇野公之
- Organizer
  Pacifichem2010
- Place of Presentation
  Honolulu, Hawaii
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Effect of Single Nucleotide Polymorphisms on the Drug Metabolizing Properties of Human Cytochrome P450 1A22010
- Author(s)
  Tadayuki Uno, Sakiko Morita, Akihide Tsujimoto, Shinji Murata, Masafumi Egawa, Taku Tamashita, Hiroshi Aoyama
- Organizer
  39th International Conference on Coordination Chemistry (ICCC39) Adelaide
- Place of Presentation
  South Australia Australia
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Resonance Raman spectroscopy reveals distinct drug orientation in human CYP2D62010
- Author(s)
  宇野公之, 山田麻由, 上村真司, 柳田詩織, 森田早紀子, 松本麻希, 青山浩, 山下沢
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Effect of Single Nucleotide Polymorphisms (SNPs) on the Drug Metabolizing Properties of Human CYP2C192010
- Author(s)
  Tadayuki Uno, Maki Matsumoto, Yumiko Iiga, Sayed M.S. Ali, Ryuichi Sasaki, Taku Yamashita, Hiroshi Aoyama
- Organizer
  The 5th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
- Place of Presentation
  Suita, Osaka, Japan
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Amino acid residues involved in the proton relay system in human CYP2C92010
- Author(s)
  宇野公之, 金森美果, 大河万顕, 香川雄輔, 山下沢, 青山浩
- Organizer
  第20回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-06-25
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Drug Binding and Metabolizing Properties of Human CYP2D62009
- Author(s)
  Tadayuki Uno, Shinji Uemura, Shiori Yanagita, Taku Yamashita, Hiroshi Aoyama
- Organizer
  14th International Conference on Biological Inorganic Chemistry (ICBIC XIV)
- Place of Presentation
  Nagoya, Aichi, Japan
- Year and Date
  2009-07-26
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP2D6の薬物結合および代謝能2009
- Author(s)
  宇野公之, 上村真司, 柳田詩織, 山下沢, 青山浩
- Organizer
  第19回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  吹田
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYPlA2の代謝活性と-塩基多型との相関2009
- Author(s)
  宇野公之、森田早紀子、辻本景英、江川真文、山下沢、青山浩
- Organizer
  第19回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  大阪大学銀杏会館
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP2D6の薬物結合性及び代謝活性2009
- Author(s)
  宇野公之, 上村真司, 柳田詩織, 山下沢, 青山浩
- Organizer
  日本薬学会129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP1A2の代謝活性と一塩基多型との相関2009
- Author(s)
  宇野公之, 森田早紀子, 辻本景英, 江川真文, 山下沢, 青山浩
- Organizer
  第19回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  吹田
- Year and Date
  2009-06-11
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP2C19の薬物結合および代謝能における一塩基多型の影響2009
- Author(s)
  宇野公之, 松本麻希, 飯賀由実子, Sayed M.S. Ali, 佐々木隆一, 山下沢, 青山浩
- Organizer
  第19回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  吹田
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒト薬物代謝酵素CYP1A2の一塩基多型と薬物代謝活性との相関2009
- Author(s)
  森田早紀子, 辻本景英, 江川真文, 山下沢, 青山浩, 宇野公之
- Organizer
  第59回日本薬学会近畿支部大会東
- Place of Presentation
  大阪
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP2D6の発現と薬物代謝活性2008
- Author(s)
  宇野公之, 上村真司, 柳田詩織, 青山浩
- Organizer
  日本生物物理学会第46回年会
- Place of Presentation
  福岡
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒト薬物代謝酵素CYP2C9の一塩基多型と薬物代謝活性の相関2008
- Author(s)
  宇野公之, 大河万顕, 香川雄輔, 渡辺亮介, 繁富輝明, 山下沢, 青山浩
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒト薬物代謝酵素CYP3A4の基質認識と薬物代謝反応機構2008
- Author(s)
  宇野公之, 服部芳明, 野中朋子, Rajamanickam Vijayalakshmi, 鶴田諒介, 山下沢, 青山浩
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Effect of Single Nucleotide Polymorphisms (SNPs) on the Drug Binding and Metabolizing Properties of Human CYP2C192008
- Author(s)
  宇野公之, 飯賀由実子, Sayed Ali, 佐々木隆一, 富杉佳計, 青山浩
- Organizer
  第18回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP2D6の発現と薬物代謝活性2008
- Author(s)
  宇野公之, 上村真司, 柳田詩織, 山下沢, 青山浩
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] ヒトCYP2D6の発現と薬物代謝活性2008
- Author(s)
  宇野公之, 上村真司, 柳田詩織, 青山浩
- Organizer
  日本生物物理学会第46回年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20390011
[Presentation] Charge at the 46th residue of Cx50 is critical for the gap junctional unitary conductance and transjunctional voltage-dependent gating
- Author(s)
  Xioling Tong, Hiroshi Aoyama, Tomitake Tsukihara, Donglin Bai
- Organizer
  2014 International Biophysics Congress
- Place of Presentation
  Brisbane, Australia
- Year and Date
  2014-08-03 – 2014-08-07
- Data Source
  KAKENHI-PROJECT-26440029
[Presentation] The residues in the first extracellular domain play an important role in transjunctional-voltage dependent gating and unitary channel conductance of Cx50 gap junctional channels
- Author(s)
  Xioling Tong, Hiroshi Aoyama, Swathy Sudhakar, Honghong Chen, Donglin Bai
- Organizer
  Biophysical Society 59th Annual Meeting
- Place of Presentation
  Baltimore, Maryland, USA
- Year and Date
  2015-02-07 – 2015-02-11
- Data Source
  KAKENHI-PROJECT-26440029

1. UNO Tadayuki (00183020)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
2. OHSHIMA Noriyasu (30360514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YAMASHITA Taku (70398246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. KONDOH Masuo (50309697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AOYAMA Hiroshi 青山 浩

青山 浩 アオヤマ ヒロシ

Research Projects

Research Products

Co-Researchers

核酸の立体構造解析を加速するパイプラインの構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ホスト-ゲストを利用した二重鎖核酸のX線結晶構造解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on molecular mechanism of paracellular pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chain Reaction of Drug Metabolism -A Comprehensive Study on the Cooperative and Competitive Drug Metabolism by CYP Isoforms

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural and functional analysis of GDE family proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Comprehensive Study on the Drug-Drug Interactions in Drug Metabolizing Enzyme CYP

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

酵素発生活性を保持した光化学系II複合体の結晶化とX線構造解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Engineered Cx26 variants established functional heterotypic Cx26/Cx43 and Cx26/Cx40 gap junction channels2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Engineered Cx40 variants increased docking and function of heterotypic Cx40/Cx43 gap junction channels2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The first extracellular domain plays an important role in unitary channel conductance of Cx50 gap junction channels2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Charge at the 46th residue of connexin 50 is crucial for the gap-junction unitary conductance and transjunctional voltage-depending gating2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] ENGINEERED CX40 VARIANTS SHOWED HETEROTYPIC COLOCALIZATION AND INCREASED GAP JUNCTIONAL COUPLING WITH CX432016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] The first extracellular domain plays an important role in single channel conductance of Cx50 gap junction channels2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Effects of Single Nucleotide Polymorphisms (SNPs) on Drug Metabolism in Human CYP2C92012

AOYAMA Hiroshi 青山浩

青山浩アオヤマヒロシ