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AOYAMA Hiroshi  青山 浩

… Alternative Names

Aoyama Hiroshi  青山 浩

青山 浩  アオヤマ ヒロシ

Less
Researcher Number 60291910
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-7915-8975
Affiliation (Current) 2025: 順天堂大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2024: 順天堂大学, 薬学部, 教授
2022 – 2023: 大阪大学, 大学院薬学研究科, 准教授
2021: 大阪大学, 薬学研究科, 准教授
2016: 大阪大学, 薬学研究科, 准教授
2012 – 2015: 大阪大学, 薬学研究科(研究院), 准教授 … More
2012 – 2013: 大阪大学, 大学院・薬学研究科, 准教授
2011: 大阪大学, 薬学研究所, 准教授
2008 – 2011: 大阪大学, 薬学研究科, 准教授
2010: 大阪大学, 大学院・薬学研究科, 准教授
1997 – 1998: 理化学研究所, 光合成科学研究室, 研究員 Less
Review Section/Research Field
Principal Investigator
Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Structural biochemistry / Biophysics
Except Principal Investigator
Physical pharmacy
Keywords
Principal Investigator
X線結晶構造解析 / 膜タンパク質 / 核酸医薬 / 人工核酸 / 構造生物学 / 構造活性相関 / クライオ電子顕微鏡 / DNAナノテクノロジー / 国際情報交換 / X線結晶構造解析 … More / リン脂質 / 脂質代謝 / X 線結晶構造解析 / 光化学系II複合体 / 光合成 … More
Except Principal Investigator
X線結晶構造解析 / 共鳴ラマン分光 / 一塩基多型 / 薬物代謝 / シトクロムP450 / シトクロムP450 Less
  • Research Projects

    (7 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (4 People)
  •  核酸の立体構造解析を加速するパイプラインの構築Principal Investigator

    • Principal Investigator
      青山 浩
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
    • Research Institution
      Juntendo University
  •  X-ray crystal structure analysis of double-stranded nucleic acids using host-guestPrincipal Investigator

    • Principal Investigator
      Aoyama Hiroshi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
    • Research Institution
      Osaka University
  •  Studies on molecular mechanism of paracellular pathwayPrincipal Investigator

    • Principal Investigator
      Aoyama Hiroshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      Osaka University
  •  Chain Reaction of Drug Metabolism -A Comprehensive Study on the Cooperative and Competitive Drug Metabolism by CYP Isoforms

    • Principal Investigator
      UNO Tadayuki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University
  •  Structural and functional analysis of GDE family proteinsPrincipal Investigator

    • Principal Investigator
      AOYAMA Hiroshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      Osaka University
  •  A Comprehensive Study on the Drug-Drug Interactions in Drug Metabolizing Enzyme CYP

    • Principal Investigator
      UNO Tadayuki
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University
  •  酵素発生活性を保持した光化学系II複合体の結晶化とX線構造解析Principal Investigator

    • Principal Investigator
      青山 浩
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biophysics
    • Research Institution
      The Institute of Physical and Chemical Research

All 2023 2016 2015 2014 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

  • [Journal Article] Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N′- methylguanidine-bridged nucleic acids2023

    • Author(s)
      Yamaguchi Takao、Horie Naohiro、Aoyama Hiroshi、Kumagai Shinji、Obika Satoshi
    • Journal Title

      Nucleic Acids Research

      Volume: 51 Issue: 15 Pages: 7749-7761

    • DOI

      10.1093/nar/gkad608

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06511
  • [Journal Article] Engineered Cx26 variants established functional heterotypic Cx26/Cx43 and Cx26/Cx40 gap junction channels2016

    • Author(s)
      Levent B. Karademir, Hiroshi Aoyama, Benny Yue, Honghong Chen, Donglin
    • Journal Title

      Biochemical Journal

      Volume: 473 Issue: 10 Pages: 1391-1403

    • DOI

      10.1042/bcj20160200

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26440029
  • [Journal Article] Engineered Cx40 variants increased docking and function of heterotypic Cx40/Cx43 gap junction channels2016

    • Author(s)
      Arjewan Jassim, Hiroshi Aoyama ,Willy G. Ye, Honghong Chen, Donglin Bai
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 90 Pages: 11-20

    • DOI

      10.1016/j.yjmcc.2015.11.026

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26440029
  • [Journal Article] The first extracellular domain plays an important role in unitary channel conductance of Cx50 gap junction channels2015

    • Author(s)
      Xiaoling Tong, Hiroshi Aoyama, Swathy Sudhakar, Honghong Chen, Brian H. Shilton, Donglin Bai
    • Journal Title

      PLOS ONE

      Volume: 10(12) Issue: 12 Pages: e0143876-e0143876

    • DOI

      10.1371/journal.pone.0143876

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26440029
  • [Journal Article] Charge at the 46th residue of connexin 50 is crucial for the gap-junction unitary conductance and transjunctional voltage-depending gating2014

    • Author(s)
      Xiaoling Tong, Hiroshi Aoyama, Tomitake Tsukihara, Donglin Bai
    • Journal Title

      The Journal of Physiology

      Volume: 592 Issue: 23 Pages: 5187-5202

    • DOI

      10.1113/jphysiol.2014.280636

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26440029
  • [Presentation] Structures of increased duplex-forming ability of oligonucleotides modified with N-tert-butyl-guanidine-bridged nucleic acids2023

    • Author(s)
      Hiroshi Aoyama, Naohiro Horie, Takao. Yamaguchi, Shuji Kumagai, Satoshi Obika
    • Organizer
      第26回国際結晶学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06511
  • [Presentation] ENGINEERED CX40 VARIANTS SHOWED HETEROTYPIC COLOCALIZATION AND INCREASED GAP JUNCTIONAL COUPLING WITH CX432016

    • Author(s)
      Arjewan Jassim, Hiroshi Aoyama, Willy G. Ye, Honghong Chen, Donglin Bai
    • Organizer
      Biophysical Society 60th Annual Meeting
    • Place of Presentation
      Los Angeles, USA
    • Year and Date
      2016-02-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26440029
  • [Presentation] The first extracellular domain plays an important role in single channel conductance of Cx50 gap junction channels2015

    • Author(s)
      Tong, Xiaoling., Aoyama, Hiroshi., Sudhakar, Swathy., Chen, Honghong., Bai, Donglin
    • Organizer
      International Gap Junction Conference
    • Place of Presentation
      Chile
    • Year and Date
      2015-04-01
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26440029
  • [Presentation] Effects of Single Nucleotide Polymorphisms (SNPs) on Drug Metabolism in Human CYP2C92012

    • Author(s)
      Tadayuki Uno, Yumi Erikawa, Masayoshi Miyamoto, Yuki Yasuhara, Taku Yamashita, Hiroshi Aoyama
    • Organizer
      Seventh International Conference on Porphyrins and Phthalocyanines
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2012-07-05
    • Data Source
      KAKENHI-PROJECT-23390011
  • [Presentation] Effects of SNPs on the metabolism of Amitriptyline in CYP2D62012

    • Author(s)
      宇野 公之, 堀井 千明, 山田 麻由, 上村 真司, 青山 浩, 山下 沢
    • Organizer
      第22回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2012-05-31
    • Data Source
      KAKENHI-PROJECT-23390011
  • [Presentation] Effects of Single Nucleotide Polymorphisms (SNPs) on the Interaction of Human CYP reductase with CYP2C19 and Its Drug Metabolizing Properties2012

    • Author(s)
      宮本 正芳, 飯賀 由実子, 松本 麻希, 安原 由樹, 青山 浩, 山下 沢, 宇野 公之
    • Organizer
      第22回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2012-05-31
    • Data Source
      KAKENHI-PROJECT-23390011
  • [Presentation] The role of lipid membrane in the course of drug metabolism by cytochrome P4502012

    • Author(s)
      宇野 公之, 安原 由樹, 宮本 正芳, 山田 麻由, 山下 沢, 青山 浩
    • Organizer
      第22回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2012-05-31
    • Data Source
      KAKENHI-PROJECT-23390011
  • [Presentation] Effect of Single Nucleotide Polymorphisms(SNPs) on the Activation of Procarcinogens in Human CYP1A22012

    • Author(s)
      Tadayuki Uno, Jun-ichi Node, Sakiko Morita, Akihide Tsujimoto, Taku Yamashita, Hiroshi Aoyama
    • Organizer
      Seventh International Conference on Porphyrins and Phthalocyanines
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2012-07-05
    • Data Source
      KAKENHI-PROJECT-23390011
  • [Presentation] Three Cytochrome P450s Responsible for the Metabolism of Amitriptyline and Imipramine2011

    • Author(s)
      Tadayuki Uno, Mayu Yamada, Shinji Uemura, Sakiko Morita, Maki Matsumoto, Hiroshi Aoyama, Taku Yamashita
    • Organizer
      15th International Conference on Biological Inorganic Chemistry
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2011-08-08
    • Data Source
      KAKENHI-PROJECT-23390011
  • [Presentation] Effect of Single Nucleotide Polymorphisms (SNPs) on the Drug Binding and Metabolizing Properties of Human CYP2C192011

    • Author(s)
      Tadayuki Uno, Masayoshi Miyamoto, Yumiko Iiga, Maki Matsumoto, Hiroshi Aoyama, Taku Yamashita
    • Organizer
      15th International Conference on Biological Inorganic Chemistry
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2011-08-08
    • Data Source
      KAKENHI-PROJECT-23390011
  • [Presentation] SNP variants reveal the crucial region for drug recognition in human CYP2C19 The International Chemical Congress of Pacific Basin Societies2010

    • Author(s)
      Maki Matsumoto, Yumiko Iiga, Sayed M.S. Ali, Ryuichi Sasaki, Taku Yamashita, Hiroshi Aoyama, Tadayuki Uno
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2010-12-17
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] Drug Binding and Metabolizing Properties of Human Cytochrome P450 1A22010

    • Author(s)
      宇野公之, 森田早紀子, 辻本景英, 江川真文, 山下沢, 青山浩
    • Organizer
      Sixth International Conference on Porphyrins and Phthalocyanines (ICPP-6)
    • Place of Presentation
      Santa Ana Pueblo, New Mexico, USA
    • Year and Date
      2010-07-06
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] Expression and purification of NADPH-cytochrome P450 oxidoreductase2010

    • Author(s)
      宇野公之, 宮本正芳, 戸山亮, 松本麻希, 金森美果, 山田麻由, 山下沢, 青山浩
    • Organizer
      第20回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      徳島
    • Year and Date
      2010-06-25
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] Proton relay system in human CYP2C9 as revealed by site-directed mutagenesis The International Chemical Congress of Pacific Basin Societies2010

    • Author(s)
      金森美果, 大河万顕, 香川雄輔, 山下沢, 青山浩, 宇野公之
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-12-17
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] Effect of Single Nucleotide Polymorphisms on the Drug Metabolizing Properties of Human Cytochrome P450 1A22010

    • Author(s)
      Tadayuki Uno, Sakiko Morita, Akihide Tsujimoto, Shinji Murata, Masafumi Egawa, Taku Tamashita, Hiroshi Aoyama
    • Organizer
      39th International Conference on Coordination Chemistry (ICCC39) Adelaide
    • Place of Presentation
      South Australia Australia
    • Year and Date
      2010-07-28
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] Resonance Raman spectroscopy reveals distinct drug orientation in human CYP2D62010

    • Author(s)
      宇野公之, 山田麻由, 上村真司, 柳田詩織, 森田早紀子, 松本麻希, 青山浩, 山下沢
    • Organizer
      第20回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      徳島
    • Year and Date
      2010-06-25
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] Effect of Single Nucleotide Polymorphisms (SNPs) on the Drug Metabolizing Properties of Human CYP2C192010

    • Author(s)
      Tadayuki Uno, Maki Matsumoto, Yumiko Iiga, Sayed M.S. Ali, Ryuichi Sasaki, Taku Yamashita, Hiroshi Aoyama
    • Organizer
      The 5th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
    • Place of Presentation
      Suita, Osaka, Japan
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] Amino acid residues involved in the proton relay system in human CYP2C92010

    • Author(s)
      宇野公之, 金森美果, 大河万顕, 香川雄輔, 山下沢, 青山浩
    • Organizer
      第20回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      徳島
    • Year and Date
      2010-06-25
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] Drug Binding and Metabolizing Properties of Human CYP2D62009

    • Author(s)
      Tadayuki Uno, Shinji Uemura, Shiori Yanagita, Taku Yamashita, Hiroshi Aoyama
    • Organizer
      14th International Conference on Biological Inorganic Chemistry (ICBIC XIV)
    • Place of Presentation
      Nagoya, Aichi, Japan
    • Year and Date
      2009-07-26
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] ヒトCYP2D6の薬物結合および代謝能2009

    • Author(s)
      宇野公之, 上村真司, 柳田詩織, 山下沢, 青山浩
    • Organizer
      第19回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      吹田
    • Year and Date
      2009-06-12
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] ヒトCYPlA2の代謝活性と-塩基多型との相関2009

    • Author(s)
      宇野公之、森田早紀子、辻本景英、江川真文、山下沢、青山浩
    • Organizer
      第19回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      大阪大学銀杏会館
    • Year and Date
      2009-06-11
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] ヒトCYP2D6の薬物結合性及び代謝活性2009

    • Author(s)
      宇野公之, 上村真司, 柳田詩織, 山下沢, 青山浩
    • Organizer
      日本薬学会129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] ヒトCYP1A2の代謝活性と一塩基多型との相関2009

    • Author(s)
      宇野公之, 森田早紀子, 辻本景英, 江川真文, 山下沢, 青山浩
    • Organizer
      第19回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      吹田
    • Year and Date
      2009-06-11
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] ヒトCYP2C19の薬物結合および代謝能における一塩基多型の影響2009

    • Author(s)
      宇野公之, 松本麻希, 飯賀由実子, Sayed M.S. Ali, 佐々木隆一, 山下沢, 青山浩
    • Organizer
      第19回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      吹田
    • Year and Date
      2009-06-12
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] ヒト薬物代謝酵素CYP1A2の一塩基多型と薬物代謝活性との相関2009

    • Author(s)
      森田早紀子, 辻本景英, 江川真文, 山下沢, 青山浩, 宇野公之
    • Organizer
      第59回日本薬学会近畿支部大会東
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] ヒトCYP2D6の発現と薬物代謝活性2008

    • Author(s)
      宇野公之, 上村真司, 柳田詩織, 青山浩
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-03
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] ヒト薬物代謝酵素CYP2C9の一塩基多型と薬物代謝活性の相関2008

    • Author(s)
      宇野公之, 大河万顕, 香川雄輔, 渡辺亮介, 繁富輝明, 山下沢, 青山浩
    • Organizer
      第58回日本薬学会近畿支部大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-25
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] ヒト薬物代謝酵素CYP3A4の基質認識と薬物代謝反応機構2008

    • Author(s)
      宇野公之, 服部芳明, 野中朋子, Rajamanickam Vijayalakshmi, 鶴田諒介, 山下沢, 青山浩
    • Organizer
      第58回日本薬学会近畿支部大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-25
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] Effect of Single Nucleotide Polymorphisms (SNPs) on the Drug Binding and Metabolizing Properties of Human CYP2C192008

    • Author(s)
      宇野公之, 飯賀由実子, Sayed Ali, 佐々木隆一, 富杉佳計, 青山浩
    • Organizer
      第18回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2008-06-05
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] ヒトCYP2D6の発現と薬物代謝活性2008

    • Author(s)
      宇野公之, 上村真司, 柳田詩織, 山下沢, 青山浩
    • Organizer
      第58回日本薬学会近畿支部大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-25
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] ヒトCYP2D6の発現と薬物代謝活性2008

    • Author(s)
      宇野公之, 上村真司, 柳田詩織, 青山浩
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-12-03
    • Data Source
      KAKENHI-PROJECT-20390011
  • [Presentation] Charge at the 46th residue of Cx50 is critical for the gap junctional unitary conductance and transjunctional voltage-dependent gating

    • Author(s)
      Xioling Tong, Hiroshi Aoyama, Tomitake Tsukihara, Donglin Bai
    • Organizer
      2014 International Biophysics Congress
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      2014-08-03 – 2014-08-07
    • Data Source
      KAKENHI-PROJECT-26440029
  • [Presentation] The residues in the first extracellular domain play an important role in transjunctional-voltage dependent gating and unitary channel conductance of Cx50 gap junctional channels

    • Author(s)
      Xioling Tong, Hiroshi Aoyama, Swathy Sudhakar, Honghong Chen, Donglin Bai
    • Organizer
      Biophysical Society 59th Annual Meeting
    • Place of Presentation
      Baltimore, Maryland, USA
    • Year and Date
      2015-02-07 – 2015-02-11
    • Data Source
      KAKENHI-PROJECT-26440029
  • 1.  UNO Tadayuki (00183020)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 28 results
  • 2.  OHSHIMA Noriyasu (30360514)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  YAMASHITA Taku (70398246)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 4.  KONDOH Masuo (50309697)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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