TAKEMURA Hitomi 竹村ひとみ

… Alternative Names

竹村ひとみタケムラヒトミ

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Researcher Number	60295558
Affiliation (Current)	2025: 愛知学泉大学, 家政学部, 教授
Affiliation (based on the past Project Information) *help	2012 – 2015: 愛知学泉大学, 家政学部, 講師 2008 – 2011: Matsumoto University, 人間健康学部, 助手 2005 – 2006: 静岡県立大学, 看護学部, 助手 2002 – 2003: 静岡県立大学, 看護学部, 助手
Review Section/Research Field	Principal Investigator Eating habits, studies on eating habits Except Principal Investigator 環境影響評価(含放射線生物学)
Keywords	Principal Investigator エストロゲン代謝 / フラボノイド / がん化学予防 / カテコールエストロゲン / DNA損傷 / ホルモン依存性がん / メトキシフラボノイド / CYP / ホルモン依存性癌 / ホルモン依存性疾患 … More / 食品因子 / がん予防 / エストロゲン / 健康と食生活 / benzo[a]prene / benzo[a]pyrene / cytochrome P450 / アリル炭化水素受容体 / DNA付加体 / Benzo[a]pyrene / 予防 / 食品成分 … More Except Principal Investigator uterus weight / inflammation / conjugating enzyme / detoxification / bisphenol A / estrogen / halogenated compounds / breast cancer / 子宮重量 / 炎症 / 抱合化酵素 / 解毒代謝 / ビスフェノールA / エストロゲン / ハロゲン置換体 / 乳癌 Less

A basic study on hormone-dependent cancer preventive effects of food factors focuses on estrogen metabolismPrincipal Investigator
- Principal Investigator
  
  Takemura Hitomi
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Aichi Gakusen University
Inhibitory effects of methoxyflavonoid on DNA damage induced by catechol estrogenPrincipal Investigator
- Principal Investigator
  
  TAKEMURA Hitomi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Matsumoto University
Inhibitory effects of methoxyflavonoid on hormone-dependent cancer related to environmental factorPrincipal Investigator
- Principal Investigator
  
  TAKEMURA Hitomi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Matsumoto University
新たな作用メカニズムに基づく食品成分中のホルモン依存性癌予防因子に関する研究Principal Investigator
- Principal Investigator
  
  竹村ひとみ
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  University of Shizuoka
Modulating effects of halogenated compounds on the metabolic detoxification of catechol estrogens and mammary carcinogenesis
- Principal Investigator
  
  SHIMOI Kayoko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  University of Shizuoka

All 2014 2013 2012 2011 2010 2009 2008 2005 Other

All Journal Article Presentation

[Journal Article] Quercetin-3-O-glucronide inhibits noradrenaline binding to α2-adrenergic receptor, thus suppressing DNA damage induced by treatment with 4-hydroxyestradiol and noradrenaline in MCF-10A cells.2014
- Author(s)
  Yamazki S., Sakakibara H., Takemura H., Yasuda M., Shimoi K.
- Journal Title
  
  J Steroid Biochem Mol Biol.
  
  Volume: 143 Pages: 122-129
- DOI
  10.1016/j.jsbmb.2014.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501003, KAKENHI-PROJECT-25882027
[Journal Article] Breast cancer and flavonoids - a role in prevention.2013
- Author(s)
  Takemura H., Sakakibara H., Yamazaki S. and Shimoi K.
- Journal Title
  
  Current Pharmaceutical Design
  
  Volume: 19 Issue: 34 Pages: 6125-6132
- DOI
  10.2174/1381612811319340006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501003
[Journal Article] 4-Hydroxyestradiol Induces γ-H2AX in the Presence of an Inhibitor of Catechol-<i>O</i>-methyltransferase in Human Breast Cancer MCF-7 Cells2012
- Author(s)
  Yamazaki S., Sakakibara H., Takemura H., Shimoi K.
- Journal Title
  
  Genes and Environment
  
  Volume: 34 Issue: 3 Pages: 129-135
- DOI
  10.3123/jemsge.34.129
- NAID
  10030688139
- ISSN
  1880-7046, 1880-7062
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501003
[Journal Article] Selective inhibition of methoxyflavonoids on human CYP1B1 activity2010
- Author(s)
  Takemura H, Itoh T, Yamamoto K, Sakakibara H, Shimoi K
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18 Issue: 17 Pages: 6310-6315
- DOI
  10.1016/j.bmc.2010.07.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700763
[Journal Article] A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells.2010
- Author(s)
  Takemura H, Uchiyama H, Ohura T, Sakakibara H, Kuruto R, Amagai T, Shimoi K.
- Journal Title
  
  J. Steroid Biochem. Mol. Biol. 118
  
  Pages: 70-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700601
[Journal Article] A 3D model of CYP1B1 explains the dominant 4-hydroxylation of estradiol2010
- Author(s)
  Itoh T, Takemura H, Shimoi K, Yamamoto K
- Journal Title
  
  J. Chem. Inf. Model
  
  Volume: 50 Issue: 6 Pages: 1173-1178
- DOI
  10.1021/ci1000554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700763
[Journal Article] A 3D model of CYP1B1 explains the dominant 4-hydroxylation of estradiol.2010
- Author(s)
  Itoh T., Takemura H., Shimoi K., Yamamoto K.
- Journal Title
  
  J.Chem.Inf.Model.
  
  Volume: 50 Pages: 1173-1178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700763
[Journal Article] A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells2010
- Author(s)
  Takemura H, Uchiyama H, Ohura T, Sakakibara H, Kuruto R, Amagai T, Shimoi K
- Journal Title
  
  J.Steroid Biochem.Mol.Biol. 118
  
  Pages: 70-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700601
[Journal Article] Selective inhibition of methoxyflavonoids on human CYP1B1 activity.2010
- Author(s)
  Takemura H., Itoh T., Yamamoto K., Sakakibara H., Shimoi K.
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 18 Pages: 6310-6315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700763
[Journal Article] In vitro and in vivo estrogenic activity of chlorinated derivatives of bisphenol A2005
- Author(s)
  Hitomi Takemura, Jie Ma, Kazutoshi Sayama, Yoshiyasu Terao, Bao Ting Zhu, Kayoko Shimoi
- Journal Title
  
  Toxicology 207
  
  Pages: 215-221
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580570
[Journal Article] In vitro and in vivo estrogenic activity of chlorinated derivatives of bisphenol A2005
- Author(s)
  Hitomi Takemura et al.
- Journal Title
  
  Toxicology 207
  
  Pages: 212-215
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580570
[Journal Article] Inhibitory effects of chrysoeriol on DNA adduct formation with benzo[a]pyrene in MCF-7 breast cancer cells.
- Author(s)
  Takemura H, Nagayoshi H, Matsuda T, Sakakibara H, Morita M, Matsui A, Ohura T, Shimoi K.
- Journal Title
  
  Toxicology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700601
[Presentation] フラボノイド類の乳がん予防における役割2014
- Author(s)
  下位香代子，竹村ひとみ，山崎隼輔，保田倫子
- Organizer
  第8回日本ポリフェノール学会学術大会
- Place of Presentation
  東京
- Year and Date
  2014-08-08
- Data Source
  KAKENHI-PROJECT-24501003
[Presentation] Chemopreventive effects of flavonoids on the breast cancer development2013
- Author(s)
  Shimoi K., Takemura H., Yamazki S., Sakakibara H. and Yasuda M.
- Organizer
  Antioxidants and Redox Process in Health
- Place of Presentation
  S. Paulo, Brazil
- Invited
- Data Source
  KAKENHI-PROJECT-24501003
[Presentation] 正常乳腺細胞MCF-10Aにおいてノルアドレナリンは受容体を介してDNA損傷を増加させる2012
- Author(s)
  山崎隼輔、榊原啓之、竹村ひとみ、下位香代子
- Organizer
  日本環境変異原学会第41回大会（静岡）
- Place of Presentation
  静岡市
- Data Source
  KAKENHI-PROJECT-24501003
[Presentation] ストレスによる乳がんの増加を未然に防ぐ食品成分の検索2011
- Author(s)
  山崎隼輔、榊原啓之、竹村ひとみ、下位香代子
- Organizer
  富士山麓アカデミック&サイエンスフェア2011
- Place of Presentation
  静岡
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22700763
[Presentation] Effects of noradrenalin on phosphorylation of histone H2AX induced with 17ss-estradiol metabolites in breast cancer cells2011
- Author(s)
  Yamazaki S, Takemura H, Shimoi K
- Organizer
  70th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Nagoya
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-22700763
[Presentation] Effects of methoxyflavonoids on estrogen metabolism?-selective inhibition ofCYP1B1activity-2011
- Author(s)
  Shimoi K, Takemura H, Sakakbiara H, Itoh T, and Yamamoto K
- Organizer
  International Conference and Exhibition on Nutraceuticals and Functional Foods2011
- Place of Presentation
  Sapporo
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-22700763
[Presentation] A methoxyflavonoid, chrysoeriol, is responsible for inhibition of DNA adduct formation by benzo[a]pyrene in MCF-7 breast cancer cells2011
- Author(s)
  Takemura H, Sakakibara H, Nagayoshi H, Ohura T, Matsuda T, Morita M, Matsui A, Shimoi K
- Organizer
  5th International Conference on Polyphenols and Health
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2011-10-19
- Data Source
  KAKENHI-PROJECT-22700763
[Presentation] A methoxyflavonoid, chrysoeriol, is responsible for inhibition of DNA adduct formation by benzo [a] pyrene in MCF-7 breast cancer cells2011
- Author(s)
  Takemura H, Sakakibara H, Nagayoshi H, Ohura T, Matsuda T, Morita M, Matsui A, and Shimoi K
- Organizer
  5th International Conference on Polyphenols and Health
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2011-10-19
- Data Source
  KAKENHI-PROJECT-22700763
[Presentation] Effects of phenolic compounds on phosphorylation of histone H2AX induced by catechol estrogen metabolites in breast cancer cells2011
- Author(s)
  Yamazaki S, Sakakibara H, Takemura H, Shimoi K
- Organizer
  5th International Conference on Polyphenols and Health
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2011-10-19
- Data Source
  KAKENHI-PROJECT-22700763
[Presentation] Inhibitory effects of dietary flavonoids on Y-H2AX induction by 17ss-estradiol metabolites and noradrenaline in breast cancer cells2011
- Author(s)
  Yamazaki S, Sakakbiara H, Takemura H, Shimoi K
- Organizer
  The 4th International Conference on Health and Longevity Sciences
- Place of Presentation
  Shizuoka
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-22700763
[Presentation] Effects of methoxy flavonoids on estrogen metabolism?-selective inhibition of CYP1B1 activity-2011
- Author(s)
  Shimoi K, Takemura H, Sakakbiara H, Itoh T, Yamamoto K
- Organizer
  International Conference and Exhibition on Nutraceuticals and Functional Foods 2011
- Place of Presentation
  Sapporo
- Year and Date
  2011-10-17
- Data Source
  KAKENHI-PROJECT-22700763
[Presentation] Chrysoeriolのbenzo[a]pyrene-DNA付加体形成に対する抑制効果2010
- Author(s)
  竹村ひとみ、永吉晴奈、松田知成、榊原啓之、森田真紀、松井朝子、大浦健、下位香代子
- Organizer
  第15回日本フードファクター学会学術集会
- Place of Presentation
  仙台市民会館(仙台市)
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-22700763
[Presentation] CYPによるエストラジオールの位置選択的水酸化機構解明に関する研究2010
- Author(s)
  伊藤俊将、竹村ひとみ、下位香代子、山本恵子
- Organizer
  日本薬学会第130年会
- Place of Presentation
  桃太郎アリーナ(岡山県)
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20700601
[Presentation] Chrysoeriol prevents formation of a carcinogenic estrogen metabolite 4-hydroxy estradiol, through the selective inhibition of CYP1B12010
- Author(s)
  Takemura H., Sakakibara H., Ohura T., Itoh T., Yamamoto K., Shimoi K.
- Organizer
  The 6^<th> International Symposium on Hormonal Oncogenesis
- Place of Presentation
  Sheraton Grande Tokyo Bay Hotel (Tokyo, Japan)
- Year and Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-22700763
[Presentation] Chrysoeriol prevents formation of a carcinogenic estrogen metabolite 4-hydroxy estradiol, through the selective inhibition of CYP1B12010
- Author(s)
  Takemura H, Sakakibara H, Ohura T, Itoh T, Yamamoto K, Shimoi K
- Organizer
  6th International Symposium on Hormonal Oncogenesis
- Place of Presentation
  Tokyo
- Year and Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-22700763
[Presentation] Chrysoeriolのbenzo [a] pyrene-DNA付加体形成に対する抑制効果2010
- Author(s)
  竹村ひとみ、永吉晴奈、松田知成、榊原啓之、森田真紀、松井朝子、大浦健、下位香代子
- Organizer
  第15回日本フードファクター学会学術集会
- Place of Presentation
  仙台市
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-22700763
[Presentation] Inhibitory selectivity of flavonoids on human CYP1A1, 1A2 and 1B1 enzymes : molecular modeling and docking study2009
- Author(s)
  竹村ひとみ、伊藤俊将、山本恵子、榊原啓之、下位香代子
- Organizer
  4^<th> International Conference on Polyphenols and Health
- Place of Presentation
  Harrogate International Centre(Harrogate, UK)
- Year and Date
  2009-12-08
- Data Source
  KAKENHI-PROJECT-20700601
[Presentation] Inhibitory selectivity of flavonoids on human CYP1A1, 1A2 and 1B1 enzymes: molecular modeling and docking study.2009
- Author(s)
  Takemura H.
- Organizer
  4th International Conference on Polyphenols and Health.
- Place of Presentation
  Harrogate International Centre (Harrogate, UK)
- Year and Date
  2009-12-08
- Data Source
  KAKENHI-PROJECT-20700601
[Presentation] ヒトCYP1酵素活性に対するフラボノイドの選択的阻害～モデリング・ドッキング解析による検証～2009
- Author(s)
  竹村ひとみ
- Organizer
  第14回日本フードファクター学会学術集会
- Place of Presentation
  神戸大学百年記念館(兵庫県)
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-20700601
[Presentation] Benzo[a]pyrene-DNA付加体形成に対するchrysoeriolの抑制効果2008
- Author(s)
  竹村ひとみ
- Organizer
  日本環境変異原学会37回大会
- Place of Presentation
  沖縄コンベンションセンター(沖縄県)
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-20700601
[Presentation] Benzo[a]pyrene-DNA付加体形成に対するchrysoeriolの抑制効果2008
- Author(s)
  竹村ひとみ
- Organizer
  日本環境変異原学会37回大会
- Place of Presentation
  沖縄県宜野湾市
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-20700601

1. SHIMOI Kayoko (10162728)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
2. TERAO Yoshiyasu (60046282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. WAKABAYASHI Keiji (60158582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKEMURA Hitomi 竹村 ひとみ

竹村 ひとみ タケムラ ヒトミ

Research Projects

Research Products

Co-Researchers

A basic study on hormone-dependent cancer preventive effects of food factors focuses on estrogen metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibitory effects of methoxyflavonoid on DNA damage induced by catechol estrogenPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibitory effects of methoxyflavonoid on hormone-dependent cancer related to environmental factorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新たな作用メカニズムに基づく食品成分中のホルモン依存性癌予防因子に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modulating effects of halogenated compounds on the metabolic detoxification of catechol estrogens and mammary carcinogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Quercetin-3-O-glucronide inhibits noradrenaline binding to α2-adrenergic receptor, thus suppressing DNA damage induced by treatment with 4-hydroxyestradiol and noradrenaline in MCF-10A cells.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Breast cancer and flavonoids - a role in prevention.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 4-Hydroxyestradiol Induces &gamma;-H2AX in the Presence of an Inhibitor of Catechol-<i>O</i>-methyltransferase in Human Breast Cancer MCF-7 Cells2012

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Selective inhibition of methoxyflavonoids on human CYP1B1 activity2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells.2010

Author(s)

Journal Title

Data Source

[Journal Article] A 3D model of CYP1B1 explains the dominant 4-hydroxylation of estradiol2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A 3D model of CYP1B1 explains the dominant 4-hydroxylation of estradiol.2010

Author(s)

Journal Title

Data Source

[Journal Article] A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells2010

Author(s)

Journal Title

Data Source

[Journal Article] Selective inhibition of methoxyflavonoids on human CYP1B1 activity.2010

Author(s)

Journal Title

Data Source

[Journal Article] In vitro and in vivo estrogenic activity of chlorinated derivatives of bisphenol A2005

TAKEMURA Hitomi 竹村ひとみ

竹村ひとみタケムラヒトミ

[Journal Article] 4-Hydroxyestradiol Induces γ-H2AX in the Presence of an Inhibitor of Catechol-<i>O</i>-methyltransferase in Human Breast Cancer MCF-7 Cells2012