Murai Noriyuki 村井法之

… Alternative Names

MURAI NORIYUKI 村井法之

村井法之ムライノリユキ

MURAI Noriyuki 村井法之

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Researcher Number	60300927
Other IDs
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 東京慈恵会医科大学, 医学部, 准教授 2021: 東京慈恵会医科大学, 医学部, 講師 2019: 東京慈恵会医科大学, 医学部, 講師 2015 – 2017: 東京慈恵会医科大学, 医学部, 講師 2010 – 2012: 東京慈恵会医科大学, 医学部, 講師 2002 – 2003: 東京慈恵会医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Gastroenterology / Functional biochemistry Except Principal Investigator Tumor biology
Keywords	Principal Investigator ユビキチン非依存的分解 / アンチザイム / プロテアソーム / MYCN / ポリアミン / 神経芽腫 / ユビキチン非依存的タンパク質分解 / 神経芽細胞腫 / アンチザイム2 / がん細胞増殖 … More / がん細胞増殖抑制 / がんの悪性度 / がんの増殖 / ユビキチン依存的分解 / アンチザイム２ / 膵臓がん / タンパク質分解 / 低酸素 / c-Myc / がん / GFP / EGFP / 細胞内局在 / リン酸化 … More Except Principal Investigator がん細胞の特性 / アンチザイム / 蛍光タンパク質 / 翻訳調節 / ポリアミン / がんの特性 Less

Development of MYCN targeting drug for high-risk type neuroblastomaPrincipal Investigator
- Principal Investigator
  
  村井法之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Jikei University School of Medicine
Elucidation of ubiquitin-independent MYCN degradation mechanism mediated by AZ2 in neuroblastoma tumorsPrincipal Investigator
- Principal Investigator
  
  MURAI NORIYUKI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Jikei University School of Medicine
Functional Significance of Interaction between MYCN and AZ2 in Neuroblastoma CellsPrincipal Investigator
- Principal Investigator
  
  MURAI NORIYUKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Fluorescent visualization of cancer cellsby monitoring cellular polyamines
- Principal Investigator
  
  MATSUFUJI Senya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Jikei University School of Medicine
Significance of the interaction between antizyme 2 and CDR2 under hypoxia in cancer cellsPrincipal Investigator
- Principal Investigator
  
  MURAI Noriyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Jikei University School of Medicine
アンチザイムの細胞内局在と相互作用分子の一細胞イメージングPrincipal Investigator
- Principal Investigator
  
  村井法之
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Jikei University School of Medicine

All 2020 2018 2017 2016 2015 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] Novel ubiquitin-independent nucleolar c-Myc degradation pathway mediated by antizyme 22018
- Author(s)
  Murai Noriyuki、Murakami Yasuko、Tajima Ayasa、Matsufuji Senya
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 3005-3005
- DOI
  10.1038/s41598-018-21189-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16156, KAKENHI-PROJECT-15K09666
[Journal Article] Polyamine regulating protein antizyme binds to ATP citrate lyase to accelerate acetyl-CoA production in cancer cells2016
- Author(s)
  Tajima, A., Murai, N., Murakami, Y., Iwamoto, T., Migita, T.,Matsufuji, S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 471 Issue: 4 Pages: 646-51
- DOI
  10.1016/j.bbrc.2016.02.084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09666
[Journal Article] Protocols for studying antizyme expression and function.2011
- Author(s)
  Murai N. Murakami Y.Matsufuji S
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 20 Pages: 237-267
- Data Source
  KAKENHI-PROJECT-22590759
[Journal Article] Protocols for studying antizyme expression and function2011
- Author(s)
  Murai N., Murakami Y, Matsufuji S
- Journal Title
  
  Methods Mol Biol
  
  Volume: 20 Pages: 237-267
- Data Source
  KAKENHI-PROJECT-22501019
[Journal Article] Protocols for studying antizyme expression and function2011
- Author(s)
  Murai N, Murakami Y, Matsufuji S
- Journal Title
  
  Methods Mol Biol
  
  Volume: 720 Pages: 237-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501019
[Journal Article] Protocols for studying antizyme expression and function2011
- Author(s)
  Murai N, Murakami Y, Matsufuji S
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 720 Pages: 237-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590759
[Presentation] 神経芽細胞腫の腫瘍増殖におけるアンチザイム２の役割2020
- Author(s)
  村井法之
- Organizer
  日本ポリアミン学会　第11回年会
- Data Source
  KAKENHI-PROJECT-19K08283
[Presentation] 神経芽細胞腫増殖におけるMYCNとアンチザイム2の関与2018
- Author(s)
  村井法之
- Organizer
  日本ポリアミン学会　第９回年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09666
[Presentation] Antizyme-Interacting Proteins in Cancer Cells2017
- Author(s)
  Noriyuki Murai
- Organizer
  Gordon Research Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09666
[Presentation] Novel ubiquitin-independent nucleolar c-Myc degradation pathway2016
- Author(s)
  Murai N
- Organizer
  4th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives
- Place of Presentation
  Tivoli(Rome)
- Year and Date
  2016-09-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09666
[Presentation] アンチザイム２とc-MYCの核小体共局在とユビキチン非依存的分解2015
- Author(s)
  村井法之
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K09666
[Presentation] Interaction between c-MYC and Antizyme 2 in the nucleolus.2015
- Author(s)
  Murai N.
- Organizer
  Gordon Research Conference -Polyamine-
- Place of Presentation
  Waterville Valley NH　ＵＳＡ
- Year and Date
  2015-06-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09666
[Presentation] 動物細胞におけるポリアミン恒常性の維持機構-アンチザイムを中心に-2013
- Author(s)
  村井法之
- Organizer
  日本農芸化学会 2013 年度大会(シンポジウム)
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22501019
[Presentation] 動物細胞におけるポリアミン恒常性の維持機構-アンチザイムを中心に-2013
- Author(s)
  村井法之
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-22501019
[Presentation] アンチザイム 2 によるc-Myc の分解促進機構とその意義2013
- Author(s)
  村井法之・村上安子・松藤千弥
- Organizer
  日本ポリアミン学会第4回年会
- Place of Presentation
  松島
- Data Source
  KAKENHI-PROJECT-22590759
[Presentation] 動物細胞におけるポリアミン恒常性の維持機構-アンチザイムを中心に-.2013
- Author(s)
  村井法之
- Organizer
  日本農芸化学会 2013 年度大会(シンポジウム)
- Place of Presentation
  仙台[抄録集4SY05-3]
- Data Source
  KAKENHI-PROJECT-22590759
[Presentation] 動物細胞におけるポリアミン恒常性の維持機構―アンチザイムを中心にー2013
- Author(s)
  村井法之
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-22590759
[Presentation] アンチザイム2によるc-Mycのユビキチン非依存的分解促進機構とその意義2013
- Author(s)
  村井法之、村上安子、松藤千弥
- Organizer
  第4回日本ポリアミン学会年会
- Place of Presentation
  松島
- Data Source
  KAKENHI-PROJECT-22590759
[Presentation] アンチザイム2 によるc-Myc の分解促進 20122012
- Author(s)
  村井法之, 村上安子, 松藤千弥
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590759
[Presentation] アンチザイム2によるc-Mycのユビキチン非依存的分解促進機構とその意義2012
- Author(s)
  村井法之、村上安子、松藤千弥
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590759
[Presentation] Regulation of c-Myc by antizyme 2 and its biological significance.2011
- Author(s)
  Murai N,Murakami Y, Matsufuji S
- Organizer
  Gordon Research Conference Polyamine
- Data Source
  KAKENHI-PROJECT-22590759
[Presentation] アンチザイム2 によるc-Myc の分解促進2011
- Author(s)
  村井法之, 村上安子, 松藤千弥
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590759
[Presentation] アンチザイム2によるc-Mycの分解促進2011
- Author(s)
  村井法之
- Organizer
  第84回生化学会大会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2011-12-24
- Data Source
  KAKENHI-PROJECT-22590759
[Presentation] Novel c-Myc degradation pathway mediated by antizyme 22011
- Author(s)
  村井法之
- Organizer
  Gordon Research Conference
- Place of Presentation
  米国ニューハンプシャー州
- Year and Date
  2011-06-20
- Data Source
  KAKENHI-PROJECT-22590759
[Presentation] アンチザイム 2 は細胞内で c-Myc の分解を促進する2011
- Author(s)
  村井法之・村上安子・松藤千弥
- Organizer
  日本ポリアミン学会第2回年会
- Place of Presentation
  宇都宮
- Data Source
  KAKENHI-PROJECT-22590759
[Presentation] Antizyme 2 accelerates c-Myc degradation in the cells2010
- Author(s)
  村井法之、清水昭博、村上安子、松藤千弥
- Organizer
  Inernational polyamine conference
- Place of Presentation
  御殿場
- Data Source
  KAKENHI-PROJECT-22590759

1. MATSUFUJI Senya (50192753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 高尾浩一 (70337484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 田島彩沙

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Murai Noriyuki 村井 法之

MURAI NORIYUKI 村井 法之

村井 法之 ムライ ノリユキ

MURAI Noriyuki 村井 法之

Research Projects

Research Products

Co-Researchers

Development of MYCN targeting drug for high-risk type neuroblastomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of ubiquitin-independent MYCN degradation mechanism mediated by AZ2 in neuroblastoma tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional Significance of Interaction between MYCN and AZ2 in Neuroblastoma CellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Fluorescent visualization of cancer cellsby monitoring cellular polyamines

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Significance of the interaction between antizyme 2 and CDR2 under hypoxia in cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アンチザイムの細胞内局在と相互作用分子の一細胞イメージングPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Novel ubiquitin-independent nucleolar c-Myc degradation pathway mediated by antizyme 22018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polyamine regulating protein antizyme binds to ATP citrate lyase to accelerate acetyl-CoA production in cancer cells2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protocols for studying antizyme expression and function.2011

Author(s)

Journal Title

Data Source

[Journal Article] Protocols for studying antizyme expression and function2011

Author(s)

Journal Title

Data Source

[Journal Article] Protocols for studying antizyme expression and function2011

Author(s)

Journal Title

Data Source

[Journal Article] Protocols for studying antizyme expression and function2011

Author(s)

Journal Title

Data Source

[Presentation] 神経芽細胞腫の腫瘍増殖におけるアンチザイム２の役割2020

Author(s)

Organizer

Data Source

[Presentation] 神経芽細胞腫増殖におけるMYCNとアンチザイム2の関与2018

Author(s)

Organizer

Data Source

[Presentation] Antizyme-Interacting Proteins in Cancer Cells2017

Author(s)

Organizer

Murai Noriyuki 村井法之

MURAI NORIYUKI 村井法之

村井法之ムライノリユキ

MURAI Noriyuki 村井法之