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Murai Noriyuki  村井 法之

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… Alternative Names

MURAI NORIYUKI  村井 法之

村井 法之  ムライ ノリユキ

MURAI Noriyuki  村井 法之

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Researcher Number 60300927
Other IDs
Affiliation (Current) 2025: 東京慈恵会医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2024: 東京慈恵会医科大学, 医学部, 准教授
2021: 東京慈恵会医科大学, 医学部, 講師
2019: 東京慈恵会医科大学, 医学部, 講師
2015 – 2017: 東京慈恵会医科大学, 医学部, 講師
2010 – 2012: 東京慈恵会医科大学, 医学部, 講師
2002 – 2003: 東京慈恵会医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Gastroenterology / Functional biochemistry
Except Principal Investigator
Tumor biology
Keywords
Principal Investigator
ユビキチン非依存的分解 / アンチザイム / プロテアソーム / MYCN / ポリアミン / 神経芽腫 / ユビキチン非依存的タンパク質分解 / 神経芽細胞腫 / アンチザイム2 / がん細胞増殖 … More / がん細胞増殖抑制 / がんの悪性度 / がんの増殖 / ユビキチン依存的分解 / アンチザイム2 / 膵臓がん / タンパク質分解 / 低酸素 / c-Myc / がん / GFP / EGFP / 細胞内局在 / リン酸化 … More
Except Principal Investigator
がん細胞の特性 / アンチザイム / 蛍光タンパク質 / 翻訳調節 / ポリアミン / がんの特性 Less
  • Research Projects

    (6 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (3 People)
  •  Development of MYCN targeting drug for high-risk type neuroblastomaPrincipal Investigator

    • Principal Investigator
      村井 法之
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Elucidation of ubiquitin-independent MYCN degradation mechanism mediated by AZ2 in neuroblastoma tumorsPrincipal Investigator

    • Principal Investigator
      MURAI NORIYUKI
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Functional Significance of Interaction between MYCN and AZ2 in Neuroblastoma CellsPrincipal Investigator

    • Principal Investigator
      MURAI NORIYUKI
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Fluorescent visualization of cancer cellsby monitoring cellular polyamines

    • Principal Investigator
      MATSUFUJI Senya
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      Jikei University School of Medicine
  •  Significance of the interaction between antizyme 2 and CDR2 under hypoxia in cancer cellsPrincipal Investigator

    • Principal Investigator
      MURAI Noriyuki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Jikei University School of Medicine
  •  アンチザイムの細胞内局在と相互作用分子の一細胞イメージングPrincipal Investigator

    • Principal Investigator
      村井 法之
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Jikei University School of Medicine

All 2020 2018 2017 2016 2015 2013 2012 2011 2010

All Journal Article Presentation

  • [Journal Article] Novel ubiquitin-independent nucleolar c-Myc degradation pathway mediated by antizyme 22018

    • Author(s)
      Murai Noriyuki、Murakami Yasuko、Tajima Ayasa、Matsufuji Senya
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 3005-3005

    • DOI

      10.1038/s41598-018-21189-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16156, KAKENHI-PROJECT-15K09666
  • [Journal Article] Polyamine regulating protein antizyme binds to ATP citrate lyase to accelerate acetyl-CoA production in cancer cells2016

    • Author(s)
      Tajima, A., Murai, N., Murakami, Y., Iwamoto, T., Migita, T.,Matsufuji, S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 471 Issue: 4 Pages: 646-51

    • DOI

      10.1016/j.bbrc.2016.02.084

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09666
  • [Journal Article] Protocols for studying antizyme expression and function.2011

    • Author(s)
      Murai N. Murakami Y.Matsufuji S
    • Journal Title

      Methods Mol Biol.

      Volume: 20 Pages: 237-267

    • Data Source
      KAKENHI-PROJECT-22590759
  • [Journal Article] Protocols for studying antizyme expression and function2011

    • Author(s)
      Murai N., Murakami Y, Matsufuji S
    • Journal Title

      Methods Mol Biol

      Volume: 20 Pages: 237-267

    • Data Source
      KAKENHI-PROJECT-22501019
  • [Journal Article] Protocols for studying antizyme expression and function2011

    • Author(s)
      Murai N, Murakami Y, Matsufuji S
    • Journal Title

      Methods Mol Biol

      Volume: 720 Pages: 237-67

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22501019
  • [Journal Article] Protocols for studying antizyme expression and function2011

    • Author(s)
      Murai N, Murakami Y, Matsufuji S
    • Journal Title

      Methods Mol Biol.

      Volume: 720 Pages: 237-67

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590759
  • [Presentation] 神経芽細胞腫の腫瘍増殖におけるアンチザイム2の役割2020

    • Author(s)
      村井法之
    • Organizer
      日本ポリアミン学会 第11回年会
    • Data Source
      KAKENHI-PROJECT-19K08283
  • [Presentation] 神経芽細胞腫増殖におけるMYCNとアンチザイム2の関与2018

    • Author(s)
      村井法之
    • Organizer
      日本ポリアミン学会 第9回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K09666
  • [Presentation] Antizyme-Interacting Proteins in Cancer Cells2017

    • Author(s)
      Noriyuki Murai
    • Organizer
      Gordon Research Conference
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09666
  • [Presentation] Novel ubiquitin-independent nucleolar c-Myc degradation pathway2016

    • Author(s)
      Murai N
    • Organizer
      4th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives
    • Place of Presentation
      Tivoli(Rome)
    • Year and Date
      2016-09-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09666
  • [Presentation] アンチザイム2とc-MYCの核小体共局在とユビキチン非依存的分解2015

    • Author(s)
      村井法之
    • Organizer
      第38回日本分子生物学会年会第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K09666
  • [Presentation] Interaction between c-MYC and Antizyme 2 in the nucleolus.2015

    • Author(s)
      Murai N.
    • Organizer
      Gordon Research Conference -Polyamine-
    • Place of Presentation
      Waterville Valley NH USA
    • Year and Date
      2015-06-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09666
  • [Presentation] 動物細胞におけるポリアミン恒常性の維持機構-アンチザイムを中心に-2013

    • Author(s)
      村井法之
    • Organizer
      日本農芸化学会 2013 年度大会(シンポジウム)
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-22501019
  • [Presentation] 動物細胞におけるポリアミン恒常性の維持機構-アンチザイムを中心に-2013

    • Author(s)
      村井法之
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Invited
    • Data Source
      KAKENHI-PROJECT-22501019
  • [Presentation] アンチザイム 2 によるc-Myc の分解促進機構とその意義2013

    • Author(s)
      村井法之・村上安子・松藤千弥
    • Organizer
      日本ポリアミン学会 第4回年会
    • Place of Presentation
      松島
    • Data Source
      KAKENHI-PROJECT-22590759
  • [Presentation] 動物細胞におけるポリアミン恒常性の維持機構-アンチザイムを中心に-.2013

    • Author(s)
      村井法之
    • Organizer
      日本農芸化学会 2013 年度大会(シンポジウム)
    • Place of Presentation
      仙台[抄録集4SY05-3]
    • Data Source
      KAKENHI-PROJECT-22590759
  • [Presentation] 動物細胞におけるポリアミン恒常性の維持機構―アンチザイムを中心にー2013

    • Author(s)
      村井法之
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Invited
    • Data Source
      KAKENHI-PROJECT-22590759
  • [Presentation] アンチザイム2によるc-Mycのユビキチン非依存的分解促進機構とその意義2013

    • Author(s)
      村井法之、村上安子、松藤千弥
    • Organizer
      第4回日本ポリアミン学会年会
    • Place of Presentation
      松島
    • Data Source
      KAKENHI-PROJECT-22590759
  • [Presentation] アンチザイム2 によるc-Myc の分解促進 20122012

    • Author(s)
      村井法之, 村上安子, 松藤千弥
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22590759
  • [Presentation] アンチザイム2によるc-Mycのユビキチン非依存的分解促進機構とその意義2012

    • Author(s)
      村井法之、村上安子、松藤千弥
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22590759
  • [Presentation] Regulation of c-Myc by antizyme 2 and its biological significance.2011

    • Author(s)
      Murai N,Murakami Y, Matsufuji S
    • Organizer
      Gordon Research Conference Polyamine
    • Data Source
      KAKENHI-PROJECT-22590759
  • [Presentation] アンチザイム2 によるc-Myc の分解促進2011

    • Author(s)
      村井法之, 村上安子, 松藤千弥
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22590759
  • [Presentation] アンチザイム2によるc-Mycの分解促進2011

    • Author(s)
      村井法之
    • Organizer
      第84回生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2011-12-24
    • Data Source
      KAKENHI-PROJECT-22590759
  • [Presentation] Novel c-Myc degradation pathway mediated by antizyme 22011

    • Author(s)
      村井法之
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      米国ニューハンプシャー州
    • Year and Date
      2011-06-20
    • Data Source
      KAKENHI-PROJECT-22590759
  • [Presentation] アンチザイム 2 は細胞内で c-Myc の分解を促進する2011

    • Author(s)
      村井法之・村上安子・松藤千弥
    • Organizer
      日本ポリアミン学会 第2回年会
    • Place of Presentation
      宇都宮
    • Data Source
      KAKENHI-PROJECT-22590759
  • [Presentation] Antizyme 2 accelerates c-Myc degradation in the cells2010

    • Author(s)
      村井法之、清水昭博、村上安子、 松藤千弥
    • Organizer
      Inernational polyamine conference
    • Place of Presentation
      御殿場
    • Data Source
      KAKENHI-PROJECT-22590759
  • 1.  MATSUFUJI Senya (50192753)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 2.  高尾 浩一 (70337484)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  田島 彩沙
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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