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Asano Yoshihide  浅野 善英

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ASANO Yoshihide  浅野 善英

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Researcher Number 60313029
Other IDs
Affiliation (Current) 2025: 東北大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 東北大学, 医学系研究科, 教授
2015 – 2021: 東京大学, 医学部附属病院, 准教授
2019: 東京大学, 医学部皮膚科, 准教授
2015: 東京大学, 医学部附属病院皮膚科, 准教授
2009 – 2015: 東京大学, 医学部附属病院, 講師
Review Section/Research Field
Principal Investigator
Dermatology / Basic Section 53050:Dermatology-related / Medium-sized Section 53:Organ-based internal medicine and related fields
Except Principal Investigator
Dermatology / Basic Section 53050:Dermatology-related
Keywords
Principal Investigator
全身性強皮症 / 血管障害 / 線維化 / Fli1 / 免疫異常 / 転写因子FLI1 / 表皮細胞 / B細胞 / 動物モデル / 転写因子 … More / マクロファージ / 転写因子ネットワーク / 臓器連関 / 真皮樹状細胞 / 臓器線維化 / 核酸医薬 / 制御性T細胞 / 皮膚免疫 / 転写因子Fli1 / 新規強皮症モデルマウス / 皮膚免疫・炎症学 / アポトーシス / IL-1 apha / マイクロニードル / 外用薬 / 皮膚病態学 / 皮膚科学 / 血管内皮細胞 / 自己免疫・炎症 / 炎症 / 国際情報交流 アメリカ合衆国 / 創傷治癒 / ボセンタン / エンドセリン / 強皮症 / 膠原病 … More
Except Principal Investigator
全身性強皮症 / 自己免疫 / 線維化 / 血管障害 / 免疫異常 / Fli1 / 皮膚硬化 / レチノイン酸 / MHC / CRISPR/Cas9 / 細胞周期 / RXRB / 繊維芽細胞 / RNAシークエンシング / 遺伝子 / 繊維化 / KLF5 / エピジェネティックス / 転写因子 / Fli1 / CD19 / ブレオマイシン / CD19 / B細胞 / 免疫学 / 肺線維化 / IL-6 / 完全フロイドアジュバンド / トポイソメラーゼI Less
  • Research Projects

    (12 results)
  • Research Products

    (140 results)
  • Co-Researchers

    (12 People)
  •  Elucidation of Systemic Sclerosis-Associated Transcription Network Induced by Fli1 Deficiency and Development of Novel TherapiesPrincipal Investigator

    • Principal Investigator
      浅野 善英
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Tohoku University
  •  A new therapeutic strategy against systemic sclerosis targeting skin immunityPrincipal Investigator

    • Principal Investigator
      ASANO YOSHIHIDE
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      Tohoku University
  •  Functional analysis of RXRB genetically identified as a susceptibility gene for systemic sclerosis

    • Principal Investigator
      Oka Akira
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Tokai University
  •  The analysis of SSc pathogenesis utilizing 9 strains of new murine modelsPrincipal Investigator

    • Principal Investigator
      Asano Yoshihide
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53050:Dermatology-related
    • Research Institution
      Tohoku University
      The University of Tokyo
  •  The analysis of systemic sclerosis pathogenesis with mice lacking the Fli1 gene in various cell typesPrincipal Investigator

    • Principal Investigator
      Asano Yoshihide
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      The University of Tokyo
  •  The development of oligonucleotide therapeutics targeting epithelial cells in systemic sclerosisPrincipal Investigator

    • Principal Investigator
      Asano Yoshihide
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      The University of Tokyo
  •  The generation of a new animal model of systemic sclerosis by focusing on environmental factors

    • Principal Investigator
      Sato Shinichi
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      The University of Tokyo
  •  The establishment of animal models of systemic sclerosis based on Fli1 deficiency

    • Principal Investigator
      Sato Shinichi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Dermatology
    • Research Institution
      The University of Tokyo
  •  The role of transcription factor Fli1 in macrophage polarization in patients with systemic sclerosisPrincipal Investigator

    • Principal Investigator
      Asano Yoshihide
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dermatology
    • Research Institution
      The University of Tokyo
  •  A new animal model of systemic sclerosis

    • Principal Investigator
      SATO Shinichi
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      The University of Tokyo
  •  The role of endothelin in the pathogenesis of vasculopathy associated with systemic sclerosisPrincipal Investigator

    • Principal Investigator
      ASANO Yoshihide
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Dermatology
    • Research Institution
      The University of Tokyo
  •  The significance of constitutive downregulation of Fli1 gene expression in the pathogenesis of dermal fibrosis and vasculopathy in systemic sclerosisPrincipal Investigator

    • Principal Investigator
      ASANO Yoshihide
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Dermatology
    • Research Institution
      The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book Other

  • [Book] 診療ガイドラインUP-TO-DATE2012

    • Author(s)
      浅野善英,佐藤伸一
    • Publisher
      メディカルレビュー社,
    • Data Source
      KAKENHI-PROJECT-24659522
  • [Book] 皮膚科サブスペシャリティーシリーズ1冊でわかる皮膚アレルギー2012

    • Author(s)
      浅野善英,佐藤伸一
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-24659522
  • [Book] WHAT’NEWin皮膚科学2012-20132012

    • Author(s)
      浅野善英,佐藤伸一
    • Publisher
      メディカルレビュー社,
    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs.2023

    • Author(s)
      Wang W, Bale S, Wei J, Yalavarthi B, Bhattacharyya D, Yan JJ, Abdala-Valencia H, Xu D, Sun H, Marangoni RG, Herzog E, Berdnikovs S, Miller SD, Sawalha AH, Tsou PS, Awaji K, Yamashita T, Sato S, Asano Y, Tiruppathi C, Yeldandi A, Schock BC, Bhattacharyya S, Varga J.
    • Journal Title

      Nat Commun.

      Volume: 14 Issue: 1 Pages: 523-523

    • DOI

      10.1038/s41467-022-33767-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K19473, KAKENHI-PROJECT-23K24354
  • [Journal Article] Native T1 mapping in early diffuse and limited systemic sclerosis, and its association with diastolic function.2023

    • Author(s)
      Purevsuren M, Uehara M, Ishizuka M, Suzuki Y, Shimbo M, Kakuda N, Ishii S, Sumida H, Miyazaki M, Yamashita T, Yoshizaki A, Asano Y, Sato S, Hatano M, Komuro I.
    • Journal Title

      J Cardiol.

      Volume: - Issue: 2 Pages: 100-107

    • DOI

      10.1016/j.jjcc.2023.03.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K19473, KAKENHI-PROJECT-23K24354
  • [Journal Article] Therapeutic effect of cyclin-dependent kinase 4/6 inhibitor on dermal fibrosis in murine models of systemic sclerosis.2022

    • Author(s)
      Yamamoto A, Saito T, Hosoya T, Kawahata K, Asano Y, Sato S, Mizoguchi F, Yasuda S, Kohsaka H.
    • Journal Title

      Arthritis and rheumatology(Hoboken,N.J.)

      Volume: 74 Issue: 5 Pages: 860-870

    • DOI

      10.1002/art.42042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K08785, KAKENHI-PROJECT-21K19473, KAKENHI-PROJECT-23K24354
  • [Journal Article] The Contribution of LIGHT (TNFSF14) to the Development of Systemic Sclerosis by Modulating IL-6 and T Helper Type 1 Chemokine Expression in Dermal Fibroblasts.2022

    • Author(s)
      Ikawa T, Ichimura Y, Miyagawa T, Fukui Y, Toyama S, Omatsu J, Awaji K, Norimatsu Y, Watanabe Y, Yoshizaki A, Sato S, Asano Y.
    • Journal Title

      J Invest Dermatol.

      Volume: 142 Issue: 6 Pages: 1541-1551

    • DOI

      10.1016/j.jid.2021.10.028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K19473, KAKENHI-PROJECT-23K24354
  • [Journal Article] Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma2021

    • Author(s)
      Miura Shunsuke、Watanabe Yusuke、Saigusa Ryosuke、Yamashita Takashi、Nakamura Kouki、Hirabayashi Megumi、Miyagawa Takuya、Yoshizaki Ayumi、Trojanowska Maria、Sato Shinichi、Asano Yoshihide
    • Journal Title

      Arthritis Research & Therapy

      Volume: 23 Issue: 1 Pages: 137-137

    • DOI

      10.1186/s13075-021-02520-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K19473
  • [Journal Article] Serum S100A12 levels: possible association with skin sclerosis and interstitial lung disease in systemic sclerosis.2021

    • Author(s)
      Omatsu J, Saigusa R, Miyagawa T, Fukui Y, Toyama S, Awaji K, Ikawa T, Norimatsu Y, Yoshizaki A, Sato S, Asano Y.
    • Journal Title

      Exp Dermatol.

      Volume: 30 Issue: 3 Pages: 409-415

    • DOI

      10.1111/exd.14218

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Journal Article] Percentage of residual B cells after 2 weeks of rituximab treatment predicts the improvement of systemic sclerosis‐associated interstitial lung disease2021

    • Author(s)
      Ebata Satoshi、Yoshizaki Ayumi、Fukasawa Takemichi、Yoshizaki‐Ogawa Asako、Asano Yoshihide、Kashiwabara Kosuke、Oba Koji、Sato Shinichi
    • Journal Title

      The Journal of Dermatology

      Volume: 49 Issue: 1 Pages: 179-183

    • DOI

      10.1111/1346-8138.16206

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K22925, KAKENHI-PROJECT-21K19473, KAKENHI-PROJECT-23K24354
  • [Journal Article] Serum levels of tissue factor pathway inhibitor: potential association with Raynaud’s phenomenon and telangiectasia in patients with systemic sclerosis.2021

    • Author(s)
      Norimatsu Y, Miyagawa T, Fukui Y, Omatsu J, Toyama S, Awaji K, Ikawa T, Watanabe Y, Yoshizaki A, Sato S, Asano Y.
    • Journal Title

      J Dermatol.

      Volume: ND Issue: 8 Pages: 1253-1256

    • DOI

      10.1111/1346-8138.15893

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Journal Article] A potential contribution of decreased serum galectin-10 levels to systemic inflammation and pulmonary vascular involvement in systemic sclerosis.2021

    • Author(s)
      Awaji K, Miyagawa T, Fukui Y, Toyama S, Omatsu J, Norimatsu Y, Ikawa T, Watanabe Y, Yoshizaki A, Sato S, Asano Y.
    • Journal Title

      Exp Dermatol.

      Volume: ND Issue: 7 Pages: 959-965

    • DOI

      10.1111/exd.14320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Journal Article] Association of serum CCL20 levels with pulmonary vascular involvement and primary biliary cholangitis in patients with systemic sclerosis.2021

    • Author(s)
      Ikawa T, Miyagawa T, Fukui Y, Minatsuki S, Maki H, Inaba T, Hatano M, Toyama S, Omatsu J, Awaji K, Norimatsu Y, Watanabe Y, Yoshizaki A, Sato S, Asano Y.
    • Journal Title

      Int J Rheum Dis.

      Volume: ND Issue: 5 Pages: 711-718

    • DOI

      10.1111/1756-185x.14103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Journal Article] Association of serum CXCL12 levels with arthropathy in patients with systemic sclerosis.2021

    • Author(s)
      Ikawa T, Miyagawa T, Fukui Y, Toyama S, Omatsu J, Awaji K, Norimatsu Y, Watanabe Y, Yoshizaki A, Sato S, Asano Y.
    • Journal Title

      Int J Rheum Dis.

      Volume: 24 Issue: 2 Pages: 260-267

    • DOI

      10.1111/1756-185x.14037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Journal Article] Serum vasohibin-1 levels: a potential marker of dermal and pulmonary fibrosis in systemic sclerosis.2021

    • Author(s)
      Yuki F, Nakamura K, Hirabayashi M, Miyagawa T, Toyama S, Omatsu J, Awaji K, Ikawa T, Norimatsu Y, Yoshizaki A, Sato S, Asano Y.
    • Journal Title

      Exp Dermatol.

      Volume: ND Issue: 7 Pages: 951-958

    • DOI

      10.1111/exd.14321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Journal Article] Decreased serum cathepsin S levels in patients with systemic sclerosis-associated interstitial lung disease.2020

    • Author(s)
      Toyama S, Yamashita T, Saigusa R, Miura S, Nakamura K, Hirabayashi M, Miyagawa T, Fukui Y, Omatsu J, Yoshizaki A, Sato S, Asano Y.
    • Journal Title

      J Dermatol.

      Volume: 47 Issue: 9 Pages: 1027-1032

    • DOI

      10.1111/1346-8138.15458

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Journal Article] Regulation of skin fibrosis by RALDH1-producing dermal dendritic cells via retinoic acid-mediated regulatory T cell induction: A role in scleroderma2020

    • Author(s)
      Miura Shunsuke、Asano Yoshihide、Saigusa Ryosuke、Yamashita Takashi、Taniguchi Takashi、Takahashi Takehiro、Ichimura Yohei、Toyama Tetsuo、Yoshizaki Ayumi、Sato Shinichi、Kadono Takafumi
    • Journal Title

      Journal of Dermatological Science

      Volume: 97 Issue: 2 Pages: 125-134

    • DOI

      10.1016/j.jdermsci.2020.01.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Journal Article] Overlapping systemic sclerosis and sarcoidosis with mutually exclusive disease activities: a case report and analysis of previous studies.2020

    • Author(s)
      Nakamura K, Sato S, Asano Y.
    • Journal Title

      Eur J Dermatol.

      Volume: 30 Pages: 50-52

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08802
  • [Journal Article] Altered properties of endothelial cells and mesenchymal stem cells underlying the development of scleroderma-like vasculopathy in Klf5+/- ;Fli1+/- mice.2020

    • Author(s)
      Nakamura K, Taniguchi T, Hirabayashi M, Yamashita T, Saigusa R, Miura S, Takahashi T, Toyama T, Ichimura Y, Yoshizaki A, Trojanowska M, Fujiu K, Nagai R, Sato S, Asano Y.
    • Journal Title

      Arthritis Rheumatol.

      Volume: 72 Issue: 12 Pages: 2136-2146

    • DOI

      10.1002/art.41423

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Journal Article] Serum delta-like 4 levels: A possible association with interstitial lung disease in systemic sclerosis.2020

    • Author(s)
      Fukui Y, Miyagawa T, Toyama S, Omatsu J, Hirabayashi M, Nakamura K, Yoshizaki A, Sato S, Asano Y.
    • Journal Title

      J Dermatol.

      Volume: 47 Issue: 4

    • DOI

      10.1111/1346-8138.15245

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08802
  • [Journal Article] Cyclophosphamide Pulse Therapy Normalizes Vascular Abnormalities in a Mouse Model of Systemic Sclerosis Vasculopathy2019

    • Author(s)
      Yamashita Takashi、Asano Yoshihide、Saigusa Ryosuke、Taniguchi Takashi、Hirabayashi Megumi、Miyagawa Takuya、Nakamura Kouki、Miura Shunsuke、Yoshizaki Ayumi、Trojanowska Maria、Sato Shinichi
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 139 Issue: 5 Pages: 1150-1160

    • DOI

      10.1016/j.jid.2018.11.016

    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Journal Article] A potential contribution of decreased galectin-7 expression in stratified epithelia to the development of cutaneous and esophageal manifestations in systemic sclerosis.2019

    • Author(s)
      Saigusa R, Yamashita T, Miura S, Hirabayashi M, Nakamura K, Miyagawa T, Fukui Y, Yoshizaki A, Sato S, Asano Y.
    • Journal Title

      Exp Dermatol.

      Volume: In press Issue: 5 Pages: 536-542

    • DOI

      10.1111/exd.13900

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-19H03680
  • [Journal Article] Facile fabrication of PEG-coated PLGA microspheres via SPG membrane emulsification for the treatment of scleroderma by ECM degrading enzymes2019

    • Author(s)
      Ohta Seiichi、Matsuura Mai、Kawashima Yuta、Cai Xinyu、Taniguchi Machiko、Okochi Hitoshi、Asano Yoshihide、Sato Shinichi、Ito Taichi
    • Journal Title

      Colloids and Surfaces B: Biointerfaces

      Volume: 179 Pages: 453-461

    • DOI

      10.1016/j.colsurfb.2019.04.028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03464, KAKENHI-PROJECT-19H03680
  • [Journal Article] Unique correlation profile of adiponectin and retinol-binding protein 4 in patients with systemic sclerosis.2019

    • Author(s)
      Asano Y, Masui Y, Toyama T, Sato S.
    • Journal Title

      J Dermatol.

      Volume: 46 Issue: 9 Pages: 819-820

    • DOI

      10.1111/1346-8138.14994

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08802, KAKENHI-PROJECT-19H03680
  • [Journal Article] Rituximab therapy is more effective than cyclophosphamide therapy for Japanese patients with anti-topoisomerase I-positive systemic sclerosis-associated interstitial lung disease.2019

    • Author(s)
      Ebata S, Yoshizaki A, Fukasawa T, Miura S, Takahashi T, Sumida H, Asano Y, Sato S.
    • Journal Title

      J Dermatol

      Volume: 46 Issue: 11 Pages: 1006-1013

    • DOI

      10.1111/1346-8138.15079

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08787, KAKENHI-PROJECT-19K08802, KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-18K19532
  • [Journal Article] Fli1 deficiency induces endothelial adipsin expression, contributing to the onset of pulmonary arterial hypertension in systemic sclerosis2019

    • Author(s)
      Miyagawa Takuya、Taniguchi Takashi、Saigusa Ryosuke、Fukayama Maiko、Takahashi Takehiro、Yamashita Takashi、Hirabayashi Megumi、Miura Shunsuke、Nakamura Kouki、Yoshizaki Ayumi、Sato Shinichi、Asano Yoshihide
    • Journal Title

      Rheumatology

      Volume: - Issue: 8 Pages: 2005-2015

    • DOI

      10.1093/rheumatology/kez517

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-19H03680
  • [Journal Article] A potential contribution of trappin-2 to the development of vasculopathy in systemic sclerosis.2019

    • Author(s)
      Miyagawa T, Asano Y, Saigusa R, Hirabayashi M, Yamashita T, Taniguchi T, Takahashi T, Nakamura K, Miura S, Yoshizaki A, Miyagaki T, Sato S.
    • Journal Title

      J Eur Acad Dermatol Venereol.

      Volume: In press Issue: 4 Pages: 753-760

    • DOI

      10.1111/jdv.15387

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-19H03680, KAKENHI-PROJECT-18K19532
  • [Journal Article] Possible association of decreased serum CXCL 14 levels with digital ulcers in patients with systemic sclerosis2019

    • Author(s)
      Fukui Yuki、Miyagawa Takuya、Hirabayashi Megumi、Yamashita Takashi、Saigusa Ryosuke、Miura Shunsuke、Nakamura Kouki、Yoshizaki Ayumi、Sato Shinichi、Asano Yoshihide
    • Journal Title

      The Journal of Dermatology

      Volume: 46 Issue: 7 Pages: 584-589

    • DOI

      10.1111/1346-8138.14914

    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Journal Article] Systemic sclerosis complicated with localized scleroderma-like lesions induced by Koebner phenomenon.2018

    • Author(s)
      Saigusa R, Asano Y, Yamashita T, Takahashi T, Nakamura K, Miura S, Ichimura Y, Toyama T, Taniguchi T, Sumida H, Tamaki Z, Miyazaki M, Yoshizaki A, Sato S.
    • Journal Title

      J Dermatol Sci.

      Volume: 89 Issue: 3 Pages: 282-289

    • DOI

      10.1016/j.jdermsci.2017.12.005

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15544, KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-16H05366
  • [Journal Article] Progranulin overproduction due to constitutively activated c-Abl/PKC-δ/Fli1 pathway contributes to the resistance of dermal fibroblasts to the anti-fibrotic effect of tumor necrosis factor-α in localized scleroderma2018

    • Author(s)
      Miyagawa Takuya、Ichimura Yohei、Nakamura Kouki、Hirabayashi Megumi、Yamashita Takashi、Saigusa Ryosuke、Miura Shunsuke、Takahashi Takehiro、Toyama Tetsuo、Taniguchi Takashi、Akamata Kaname、Yoshizaki Ayumi、Sato Shinichi、Asano Yoshihide
    • Journal Title

      Journal of Dermatological Science

      Volume: 92 Issue: 2 Pages: 207-214

    • DOI

      10.1016/j.jdermsci.2018.09.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05366
  • [Journal Article] An orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis2018

    • Author(s)
      Yamashita Takashi、Lakota Katja、Taniguchi Takashi、Yoshizaki Ayumi、Sato Shinichi、Hong Wen、Zhou Xingchun、Sodin-Semrl Snezn、Fang Feng、Asano Yoshihide、Varga John
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 11843-11843

    • DOI

      10.1038/s41598-018-29901-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05366, KAKENHI-PROJECT-17K16324, KAKENHI-PROJECT-18K19532
  • [Journal Article] Fli1 Deficiency Induces CXCL6 Expression in Dermal Fibroblasts and Endothelial Cells, Contributing to the Development of Fibrosis and Vasculopathy in Systemic Sclerosis.2017

    • Author(s)
      Taniguchi T, Asano Y, Nakamura K, Yamashita T, Saigusa R, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Sato S.
    • Journal Title

      J Rheumatol.

      Volume: 44 Issue: 8 Pages: 1198-1205

    • DOI

      10.3899/jrheum.161092

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16323, KAKENHI-PROJECT-17K16324, KAKENHI-PROJECT-16H05366, KAKENHI-PROJECT-17H04239
  • [Journal Article] Possible pro-inflammatory role of heparin-binding epidermal growth factor-like growth factor in the active phase of systemic sclerosis2017

    • Author(s)
      Hirabayashi Megumi、Asano Yoshihide、Yamashita Takashi、Miura Shunsuke、Nakamura Kouki、Taniguchi Takashi、Saigusa Ryosuke、Takahashi Takehiro、Ichimura Yohei、Miyagawa Takuya、Yoshizaki Ayumi、Miyagaki Tomomitsu、Sugaya Makoto、Sato Shinichi
    • Journal Title

      The Journal of Dermatology

      Volume: 45 Issue: 2 Pages: 182-188

    • DOI

      10.1111/1346-8138.14088

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04239, KAKENHI-PROJECT-16H05366
  • [Journal Article] Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.2017

    • Author(s)
      Takehiro Takahashi, Yoshihide Asano, Koji Sugawara, Kouki Nakamura, Takashi Yamashita, Ryosuke Saigusa, Yohei Ichimura, Tetsuo Toyama, Takashi Taniguchi, Kaname Akamata, Shinji Noda, Ayumi Yoshizaki, Daisuke Tsuruta, Maria Trojanowska, and Shinichi Sato
    • Journal Title

      Journal of Experimental Medicine

      Volume: 214 Issue: 4 Pages: 1129-1151

    • DOI

      10.1084/jem.20160247

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H06165, KAKENHI-PROJECT-16K15544, KAKENHI-PROJECT-17K16324, KAKENHI-PROJECT-16H05366, KAKENHI-PROJECT-16H06754
  • [Journal Article] The impact of transcription factor Fli1 deficiency on the regulation of angiogenesis2017

    • Author(s)
      Tetsuo Toyama, Yoshihide Asano, Takuya Miyagawa, Kouki Nakamura, Megumi Hirabayashi, Takashi Yamashita, Ryosuke Saigusa, Shunsuke Miura, Yohei Ichimura, Takehiro Takahashi, Takashi Taniguchi, Ayumi Yoshizaki, Shinichi Sato.
    • Journal Title

      Experimental Dermatology

      Volume: in press Issue: 10 Pages: 912-918

    • DOI

      10.1111/exd.13341

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05366
  • [Journal Article] Systemic Sclerosis Dermal Fibroblasts Suppress Th1 Cytokine Production via Galectin-9 Overproduction due to Fli1 Deficiency2017

    • Author(s)
      Saigusa Ryosuke、Asano Yoshihide、Nakamura Kouki、Hirabayashi Megumi、Miura Shunsuke、Yamashita Takashi、Taniguchi Takashi、Ichimura Yohei、Takahashi Takehiro、Yoshizaki Ayumi、Miyagaki Tomomitsu、Sugaya Makoto、Sato Shinichi
    • Journal Title

      J Invest Dermatol

      Volume: 137 Issue: 9 Pages: 1850-1859

    • DOI

      10.1016/j.jid.2017.04.035

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05366
  • [Journal Article] A potential contribution of psoriasin to vascular and epithelial abnormalities and inflammation in systemic sclerosis2017

    • Author(s)
      Takahashi T.、Asano Y.、Yamashita T.、Nakamura K.、Saigusa R.、Miura S.、Ichimura Y.、Toyama T.、Hirabayashi M.、Taniguchi T.、Yoshizaki A.、Sato S.
    • Journal Title

      Journal of the European Academy of Dermatology and Venereology

      Volume: 32 Issue: 2 Pages: 291-297

    • DOI

      10.1111/jdv.14459

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16324, KAKENHI-PROJECT-16H05366, KAKENHI-PROJECT-16K15544
  • [Journal Article] A potential contribution of altered cathepsin L expression to the development of dermal fibrosis and vasculopathy in systemic sclerosis.2016

    • Author(s)
      Yamashita T, Asano Y, Taniguchi T, Nakamura K, Saigusa R, Takahashi T, Ichimura Y, Toyama T, Yoshizaki A, Miyagaki T, Sugaya M, Sato S.
    • Journal Title

      Exp Dermatol.

      Volume: 25 Issue: 4 Pages: 287-292

    • DOI

      10.1111/exd.12920

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Journal Article] Fli1 deficiency contributes to the downregulation of endothelial protein C receptor in systemic sclerosis: a possible role in prothrombotic conditions.2016

    • Author(s)
      Saigusa R, Asano Y, Yamashita T, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Yoshizaki A, Miyagaki T, Sugaya M, Sato S.
    • Journal Title

      Br J Dermatol.

      Volume: 174 Issue: 2 Pages: 338-347

    • DOI

      10.1111/bjd.14183

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Journal Article] Endothelin receptor blockade ameliorates vascular fragility in endothelial cell-specific Fli1 knockout mice by increasing Fli1 DNA-binding ability.2015

    • Author(s)
      Akamata K, Asano Y, Yamashita T, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Trojanowska M, Sato S.
    • Journal Title

      Arthritis Rheumatol.

      Volume: - Issue: 5 Pages: 1335-1344

    • DOI

      10.1002/art.39062

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Journal Article] Fibrosis, vascular activation, and immune abnormalities resembling systemic sclerosis in bleomycin-treated Fli-1-haploinsufficient mice.2015

    • Author(s)
      Taniguchi T, Asano Y, Akamata K, Noda S, Takahashi T, Ichimura Y, Toyama T, Trojanowska M, Sato S.
    • Journal Title

      Arthritis Rheumatol.

      Volume: 67 Issue: 2 Pages: 517-526

    • DOI

      10.1002/art.38948

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Journal Article] Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1.2014

    • Author(s)
      Akamata K, Asano Y, et al.
    • Journal Title

      Arthritis Res Ther.

      Volume: 16

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Journal Article] Fli1 deficiency contributes to the suppression of endothelial CXCL5 expression in systemic sclerosis.2014

    • Author(s)
      Ichimura Y, AsanoY, et al.
    • Journal Title

      Arch Dermatol Res.

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Journal Article] Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis2014

    • Author(s)
      Noda, S
    • Journal Title

      Nat Commun

      Volume: 5 Issue: 1 Pages: 5797-5797

    • DOI

      10.1038/ncomms6797

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22229006, KAKENHI-PROJECT-25461663, KAKENHI-PROJECT-26461125
  • [Journal Article] Presence of desaturated hemoglobin enhances the contribution of blood cells to flow-mediated dilation in subjects with systemic sclerosis2013

    • Author(s)
      Amiya E, Takata M, Watanabe M, Takahashi T, Asano Y, Hatano M, Ozeki A, Watanabe A, Kawarasaki S, Tamaki Z, Taniguchi T, Ichimura Y, Toyama T, Nagai R, Sato S, Komuro I.
    • Journal Title

      Int J Cardiol

      Volume: 168(3) Pages: 3125-3127

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis2013

    • Author(s)
      Noda S, Asano Y, Takahashi T, Akamata K, Aozasa N, Taniguchi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S
    • Journal Title

      Rheumatology (Oxford)

      Volume: 52 Pages: 790-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791256
  • [Journal Article] Serum apelin levels : clinical association with vascular involvements in patients with systemic sclerosis2013

    • Author(s)
      Aozasa N, Asano Y, Akamata K, Noda S, Masui Y, Yamada D, Tamaki Z, Tada Y, Sugaya M, Kadono T, Sato S.
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: 27(1) Pages: 37-42

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] A possible contribution of visfatin to the resolution of skin sclerosis in patients with diffuse cutaneous systemic sclerosis via a direct anti-fibrotic effect on dermal fibroblasts and Th1 polarization of the immune response2013

    • Author(s)
      Masui Y, Asano Y, Shibata S, Noda S, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T.
    • Journal Title

      Rheumatology (Oxford)

      Volume: 52 Pages: 1239-1244

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Serum resistin levels : a possible correlation with pulmonary vascular involvement in patients with systemic sclerosis2013

    • Author(s)
      Masui Y, Asano Y, Akamata K, Aozasa N, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T.
    • Journal Title

      Rheumatol Int

      Volume: (Epub ahead of point)

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Clinical significance of serum retinol binding protain-4 levels in patients with systemic sclerosis2013

    • Author(s)
      Toyama T, Asano Y, Takahashi T, Aozasa N, Akamata K, Noda S, Taniguchi T, Ichimura Y, Sumida H, Tamaki Z, Masui Y, Tada Y, Sugaya M, Sato S, Kadono T.
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: 27(3) Pages: 337-344

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Fli1 deficiency contributes to the suppression of endothelial CXCL5 expression in systemic sclerosis2013

    • Author(s)
      Ichimura Y, Asano Y, Akamata K, Takahashi T, Noda S, Taniguchi T, Toyama T, Aozasa N, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T.
    • Journal Title

      Arch Dermatol Res

      Volume: (Epub ahead of point)

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Serum chemokine levels as prognostic markers in patients with early systemic sclerosis : a multicenter,prospective,observational study2013

    • Author(s)
      Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Ogawa F, Takahashi H, Tanaka S, Sato S, Takehara K.
    • Journal Title

      Mod Rheum

      Volume: 23(6) Pages: 1076-1084

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Serum levels of ADAM12-S : possible association with the initiation and progression of dermal fibrosis and interstitial lung disease in patients with systemic sclerosis2013

    • Author(s)
      Taniguchi T, Asano Y, Akamata K, Aozasa N, Noda S, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S.
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: 27(6) Pages: 747-753

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] A possible contribution of decreased cathepsin V expression caused by Fli deficiency to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis2013

    • Author(s)
      Noda S, Asano Y, Takahashi T, Akamata K, Aozasa N, Taniguchi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S.
    • Journal Title

      Rheumatology

      Volume: 52(5) Pages: 790-799

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Serum angiopoietin-like protein 3 levels : a possible correlation with progressive skin sclerosis, digital ulcers, and pulmonary vascular involvement in patients with systemic sclerosis2013

    • Author(s)
      Ichimura Y, Asano Y, Akamata K, Aozasa N, Noda S, Taniguchi T, Takahashi T, Toyama T, Sumida H, Kuwano Y, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T.
    • Journal Title

      Acta Derm-Venereol

      Volume: (Epub ahead of point)

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] The dynamics of serum angiopoietin-2 levels correlates with the efficacy of intravenous cyclophosphamide pulse for interstitial lung disease associated with systemic sclerosis2013

    • Author(s)
      Takahashi T, Asano Y, Akamata K, Aozasa N, Taniguchi T, Noda S, Masui Y, Ichimura Y, Toyama T, Tamaki Z, Tada Y, Sugaya M, Kadono T, Sato S.
    • Journal Title

      Mod Rheumatol

      Volume: 23(5) Pages: 884-890

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Decrease in circulating autotaxin by oral administration of prednisolone2013

    • Author(s)
      Sumida H
    • Journal Title

      Clin Chim Acta

      Volume: 415 Pages: 74-80

    • DOI

      10.1016/j.cca.2012.10.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249017, KAKENHI-PROJECT-23390061, KAKENHI-PROJECT-24659522, KAKENHI-PROJECT-24791138, KAKENHI-PUBLICLY-23116502
  • [Journal Article] Clinical significance of serum growth differentiation factor-15 levels in systemic sclerosis : association with disease severity2012

    • Author(s)
      Yanaba K, Asano Y, Tada Y, Sugaya M, Kadono T, Sato S.
    • Journal Title

      Mod Rheumatol

      Volume: 22(5) Pages: 668-675

    • NAID

      10031027596

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Clinical significance of circulating platelet-activating factor acetylhydrolase levels in systemic sclerosis2012

    • Author(s)
      Yanaba K, Asano Y, Tada Y, Sugaya M, Kadono T, Sato S.
    • Journal Title

      Arch Dermatol Res

      Volume: 304(3) Pages: 203-208

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Increased serum soluble CD147 levels in patients with systemic sclerosis : association with scleroderma renal crisis2012

    • Author(s)
      Yanaba K, Asano Y, Tada Y, Sugaya M, Kadono T, Hamaguchi Y, Sato S.
    • Journal Title

      Clin Rheumatol

      Volume: 31(5) Pages: 835-839

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis2012

    • Author(s)
      Noda S, Asano Y, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S.
    • Journal Title

      PLos One

      Volume: 7(2)

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Augmented production of soluble CD93 in patients with systemic sclerosis and clinical association with severity of skin sclerosis2012

    • Author(s)
      Yanaba K, Asano Y, Noda S, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Kuwano Y, Tada Y, Sugaya M, Kadono T, Sato S.
    • Journal Title

      Br J Dermatol

      Volume: 167(3) Pages: 542-547

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Clinical significance of serum levels of secretory leukocyte protease inhibitor in patients with systemic sclerosis2012

    • Author(s)
      Aozasa N, Asano Y, Akamata K, Noda S, Masui Y, Tamaki Z, Tada Y, Sugaya M, Kadono T, Sato S.
    • Journal Title

      Mod Rheumatol

      Volume: 22(4) Pages: 576-583

    • NAID

      10031027168

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Clinical significance of serum decoy receptor 3 levels in patints with systemic sclerosis2012

    • Author(s)
      Yamada D, Asano Y, Takahashi T, Masui Y, Aozasa N, Akamata K, Noda S, Tamaki Z, Tada Y, Sugaya M, Sato S, Kadono T.
    • Journal Title

      Eur J Dermatol

      Volume: 22(3) Pages: 351-357

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Effects of bosentan on non-digital ulcers in patients with systemic sclerosis2012

    • Author(s)
      Taniguchi T, Asano Y, Hatano M, Tamaki Z, Tomita M, Kawashima T, Miyazaki M, Sumida H, Akamata K, Takahashi T, Ichimura Y, Toyama T, Sugita M, Noda S, Yao A, Kinugawa K, Sato S.
    • Journal Title

      Br J Dermatol

      Volume: 166(2) Pages: 417-421

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Clinical significance of monitoring serum adiponectin levels during intravenous pulse cyclophosphamide therapy in interstitial lung disease associated with systemic sclerosis2012

    • Author(s)
      Masui Y, Asano Y, Takahashi T, Shibata S, Akamata K, Aozasa N, Noda S, Taniguchi T, Ichimura Y, Toyama T, Tamaki Z, Sumida H, Yanaba K, Tada Y, Sugaya M, Sato S, Kadono T.
    • Journal Title

      2012 Mod Rheumatol

      Volume: 23(2) Pages: 323-329

    • NAID

      10031167705

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Investigation of prognostic factors for skin sclerosis and lungfunction in Japanese patients with early systemic prospect observational study.sclerosis : a multicentre2012

    • Author(s)
      Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Muro Y, Ogawa F, Sasaki T, Takahashi H, Tanaka S, Takehara K, Sato S.
    • Journal Title

      Rheumatology (Oxford)

      Volume: 51(1)

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis2012

    • Author(s)
      Noda S, Asano Y, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S
    • Journal Title

      PLoS One

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791256
  • [Journal Article] A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis.2012

    • Author(s)
      Noda S, Asano Y, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Yanaba K, Tada Y, Sugaya M, Kadono T, Sato S.
    • Journal Title

      PLoS One

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791256
  • [Journal Article] Serum levels of galectin-3 : possible association with fibrosis, aberrant angiogenesis, and immune activation in patients with systemic sclerosis2012

    • Author(s)
      Taniguchi T, Asano Y, Akamata K, Noda S, Masui Y, Yamada D, Takahashi T, Ichimura Y, Toyama T, Tamaki Z, Tada Y, Sugaya M, Kadono T, Sato S.
    • Journal Title

      J Rheumato

      Volume: l39(3) Pages: 539-544

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Serum adiponectin levels inversely correlate with the activity of progressive skin sclerosis in patients with diffuse cutaneous systemic sclerosis2012

    • Author(s)
      Masui Y, Asano Y, Shibata S, Noda S, Aozasa N, Akamata K, Yamada D, Tamaki Z, Tada Y, Sugaya M, Sato S, Kadono T.
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: 26(3) Pages: 354-360

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] A possible contribution of elevated serum clusterin levels to the development of digital ulcers and pulmonary arterial hypertension in systemic sclerosis2012

    • Author(s)
      Yanaba K, Asano Y, Tada Y, Sugaya M, Kadono T, Sato S.
    • Journal Title

      Arch Dermatol Res

      Volume: 304(6) Pages: 459-463

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Effects of bosentan on nondigital ulcers in patients with systemic sclerosis.2012

    • Author(s)
      Taniguchi T, Asano Y, Hatano M, Tamaki Z, Tomita M, Kawashima T, Miyazaki M, Sumida H, Akamata K, Takahashi T, Ichimura Y, Toyama T, Sugita M, Noda S, Yao A, Kinugawa K, Sato S.
    • Journal Title

      Br J Dermatol.

      Volume: 166 Pages: 417-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791256
  • [Journal Article] Constitutive activation of c-Abl/protein kinase C-δ/Fli pathway in dermal fibroblasts derived from patients with localized scleroderma2012

    • Author(s)
      Noda S, Asano Y, Akamata K, Aozasa N, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sumida H, Yanaba Y, Tada Y, Sugaya M, Kadono T, Sato S.
    • Journal Title

      Br J Dermatol

      Volume: 167(5) Pages: 1098-1105

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Serum levels of soluble CD21 in patients with systemic sclerosis2012

    • Author(s)
      Tomita M, Kaodono T, Yazawa N, Kawashima T, Tamaki Z, Ashida R, Ohmatsu H, Asano Y, Sugaya M, Kubo M, Ihn H, Tamaki K, Sato S.
    • Journal Title

      Rheumatol Int

      Volume: 32(2) Pages: 317-321

    • Data Source
      KAKENHI-PROJECT-24659522
  • [Journal Article] Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis with multiple digital ulcers and gangrene.2011

    • Author(s)
      Ichimura Y, Asano Y, Hatano M, Tamaki Z, Takekoshi T, Kogure A, Tomita M, Kawashima T, Miyazaki M, Taniguchi T, Takahashi T, Mitsui H, Sugaya M, Yao A, Kinugawa K, Sato S.
    • Journal Title

      Mod Rheumatol.

      Volume: 21 Pages: 548-52

    • NAID

      10030205881

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791256
  • [Journal Article] The c-abl tyrosine kinase controls PKC δ induced Fli1 phosphorylation in human dermal fibroblasts.2011

    • Author(s)
      Bujor AM, Asano Y, Haines P, Lafyatis R, Trojanowska M.
    • Journal Title

      Arthritis Rheum

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Journal Article] Future treatments in systemic sclerosis.2010

    • Author(s)
      Asano Y.
    • Journal Title

      J Dermatol.

      Volume: 37 Pages: 54-70

    • NAID

      10027065266

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Journal Article] The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis.2010

    • Author(s)
      Asano Y, Bujor AM, Trojanowska M.
    • Journal Title

      J Dermatol Sci.

      Volume: 59 Pages: 153-162

    • NAID

      10027473153

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Journal Article] Endothelial Fli1 deficiency impairs vascular homeostasis : a role in scleroderma vasculopathy.2010

    • Author(s)
      Asano Y, Stawski L, Hant F, Highland K, Silver R, Szalai G, Watson DK, Trojanowska M.
    • Journal Title

      Am J Pathol

      Volume: 176 Pages: 1983-1998

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Journal Article] Endothelial Fli1 deficiency impairs vascular homeostasis-a role in scleroderma vasculopathy.2010

    • Author(s)
      Asano Y, Stawski L, Hant F, Highland K Silver R, Szalai G, Watson DK, Trojanowska M.
    • Journal Title

      Am J Pathol.

      Volume: 176 Pages: 1983-1998

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Journal Article] The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis.2010

    • Author(s)
      Asano Y, Bujor AM, Trojanowska M.
    • Journal Title

      J Dermatol Sci

      Volume: 59 Pages: 153-162

    • NAID

      10027473153

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Journal Article] Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensinhomolog levels.2010

    • Author(s)
      Bu S, Asano Y, Bujor A, Highland K, Hant F, Trojanowska M.
    • Journal Title

      Arthritis Rheum

      Volume: 62 Pages: 2117-2126

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Journal Article] The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis.2010

    • Author(s)
      Asano Y, Bujor AM, Trojanowska M.
    • Journal Title

      J Dermatol Sci. 59

      Pages: 153-162

    • NAID

      10027473153

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Journal Article] Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy.2010

    • Author(s)
      Asano Y, Stawski L, Hant F, Highland K, Silver R, Szalai G, Watson DK,Trojanowska M.
    • Journal Title

      Am J Pathol. 176

      Pages: 1983-1998

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Journal Article] The c-abl tyrosine kinase controls PKC-delta induced Fli1 phosphorylation in human dermal fibroblasts.

    • Author(s)
      Bujor AM, Asano Y, Haines P, Lafyatis R, Trojanowska M.
    • Journal Title

      Arthritis Rheum. in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Presentation] What can we learn from Fli1-deficient mice, new animal models of systemic sclerosis?2023

    • Author(s)
      Yoshihide Asano
    • Organizer
      The 49th Annual Meeting of TDA.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24354
  • [Presentation] 会頭特別企画1 Dermatropic/trophic 他科領域と繋がる皮膚科研究 皮膚と他臓器病変をつなぐ:全身性強皮症2021

    • Author(s)
      浅野善英
    • Organizer
      第120回日本皮膚科学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K19473
  • [Presentation] Skin research provides a window into new aspects of systemic disease pathogenesis2019

    • Author(s)
      Yoshihide Asano
    • Organizer
      The 44th Annual Meeting of JSID
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Presentation] Vascular abnormalities in systemic sclerosis2019

    • Author(s)
      Yoshihide Asano
    • Organizer
      24th World Congress of Dermatology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Presentation] 全身性強皮症患者に伴う限局性強皮症様皮疹に関する検討2019

    • Author(s)
      浅野善英
    • Organizer
      第22回強皮症研究会議
    • Data Source
      KAKENHI-PROJECT-16K15544
  • [Presentation] Myeloid cell-specific Fli1 knockout mice exhibit systemic sclerosis-like vasculopathy and delayed wound healing due to impaired vasculogenesis.2019

    • Author(s)
      Yuki Fukui, Takuya Miyagawa, Kouki Nakamura, Megumi Hirabayashi, Jun Omatsu, Satoshi Toyama, Ayumi Yoshizaki, Shinichi Sato, Yoshihide Asano.
    • Organizer
      The 49th Annual ESDR Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03680
  • [Presentation] Skin research provides a window into new aspects of systemic disease pathogenesis2018

    • Author(s)
      Yoshihide Asano
    • Organizer
      International Investigative Dermatology 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05366
  • [Presentation] Skin research provides a window into new aspects of systemic disease pathogenesis2018

    • Author(s)
      Yoshihide Asano
    • Organizer
      1st Joint Symposium of Department of Dermatology, Seoul National University and The University of Tokyo
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15544
  • [Presentation] A new murine model of PAH associated with SSc - a potential tool to investigate the pathogenesis of this clinical entity2018

    • Author(s)
      Yoshihide Asano
    • Organizer
      The 22nd Annual Scientific Meeting of the Japanese Heart Failure Society
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05366
  • [Presentation] Skin research provides a window into new aspects of systemic disease pathogenesis2018

    • Author(s)
      Yoshihide Asano
    • Organizer
      International Investigative Dermatology 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15544
  • [Presentation] Skin research provides a window into new aspects of systemic disease pathogenesis2018

    • Author(s)
      Yoshihide Asano
    • Organizer
      1st Joint Symposium of Department of Dermatology, Seoul National University and The University of Tokyo
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05366
  • [Presentation] A road from basic research to clinical trials - to meet patients’ DesiReS -2018

    • Author(s)
      Yoshihide Asano
    • Organizer
      International Investigative Dermatology 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05366
  • [Presentation] A new murine model of systemic sclerosis; Klf5+/-;Fli1+/- mice2018

    • Author(s)
      Yoshihide Asano
    • Organizer
      The 6th International Conference on Biology and Pathobiology of KLF/Sp Transcription Factors
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05366
  • [Presentation] Fli1 deficiency promotes CXCL13 expression from macrophages, contributing to the development of systemic sclerosis.2017

    • Author(s)
      Taniguchi T, Asano Y, Yamashita T, Nakamura K, Saigusa R, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Sato S.
    • Organizer
      47th Annual ESDR Meeting 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05366
  • [Presentation] Fli1 deficiency potentially regulates M2 macrophage / B cell axis in systemic sclerosis.2017

    • Author(s)
      Taniguchi T, Asano Y, Yamashita T, Nakamura K, Saigusa R, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Sato S.
    • Organizer
      The 42nd Annual Meeting of the Society for Investigative Dermatology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05366
  • [Presentation] 上皮細胞の形質異常から見えてきた 強皮症の新たな病態仮説2017

    • Author(s)
      浅野善英
    • Organizer
      第80回 日本皮膚科学会東京支部学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2017-02-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15544
  • [Presentation] Fli1-deficient B cells contribute to the development of tissue fibrosis, vasculopathy, and immune abnormalities characteristic of systemic sclerosis2017

    • Author(s)
      Asano Y
    • Organizer
      15th International Workshop on Scleroderma Research
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05366
  • [Presentation] 骨髄系細胞におけるFli1の恒常的発現低下が血管の恒常性に及ぼす影響についての検討2015

    • Author(s)
      谷口隆志、浅野善英、赤股要、野田真史、高橋岳浩、市村洋平、遠山哲夫、三枝良輔、吉崎歩、佐藤伸一
    • Organizer
      日本臨床免疫学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-10-22
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Presentation] Fli1 deficiency contributes to the downregulation of endothelial protein C receptor in systemic sclerosis: a possible role in pro-thrombotic condition2015

    • Author(s)
      Saigusa R, Asano Y, Yamashita T, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Yoshizaki A, Miyagaki T, Sugaya M, Sato S.
    • Organizer
      The 2015 American College of Rheumatology Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2015-11-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Presentation] 強皮症と転写因子2014

    • Author(s)
      浅野善英
    • Organizer
      第58回日本リウマチ学会総会
    • Place of Presentation
      東京、グランドプリンスホテル新高輪 国際パミール館
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Presentation] Fli1 haploinsufficiency exacerbates dermal fibrosis via activation of fibroblasts, endothelial cells and macrophages in bleomycin-treated mice.2013

    • Author(s)
      Takashi Taniguchi, Yoshihide Asano, et al.
    • Organizer
      The 2013 American College of Rheumatology Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Presentation] 強皮症 ~線維化から考える~2013

    • Author(s)
      浅野善英
    • Organizer
      第112回日本皮膚科学会総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Presentation] Downregulation of KLF5 and Fli1 cooperatively contribute to distinct manifestations of systemic sclerosis in vitro and in vivo.2013

    • Author(s)
      Yoshihide Asano, et al.
    • Organizer
      The 2013 American College of Rheumatology Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Presentation] 強皮症の基礎と臨床2012

    • Author(s)
      浅野善英
    • Organizer
      第61回東海膠原病研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-07-14
    • Data Source
      KAKENHI-PROJECT-23791256
  • [Presentation] 強皮症の血管障害2012

    • Author(s)
      浅野善英
    • Organizer
      日本皮膚科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2012-06-02
    • Data Source
      KAKENHI-PROJECT-23791256
  • [Presentation] The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis2012

    • Author(s)
      Asano Y
    • Organizer
      The 37th annual meeting of JSID
    • Place of Presentation
      沖縄
    • Year and Date
      2012-12-08
    • Data Source
      KAKENHI-PROJECT-23791256
  • [Presentation] 強皮症の血管障害2012

    • Author(s)
      浅野善英
    • Organizer
      日本皮膚科学会総会
    • Place of Presentation
      京都国際会議場
    • Invited
    • Data Source
      KAKENHI-PROJECT-23791256
  • [Presentation] Bosentan reverses the profibrotic phenotype of systemic sclerosis dermal fibroblasts through increasing the DNA binding ability of transcription factor Fli12011

    • Author(s)
      Kaname Akamata, Yoshihide Asano, Shinichi Sato.
    • Organizer
      2011 The 75th Annual Scientific Meeting of American College of Rheumatology
    • Place of Presentation
      Chicago, USA
    • Data Source
      KAKENHI-PROJECT-23791256
  • [Presentation] Bosentan reverses the profibrotic phenotype of systemic sclerosis dermal fibroblasts through increasing the DNA binding ability of transcription factor Fli12011

    • Author(s)
      Akamata K, Asano Y, Sato S
    • Organizer
      The75th Annual Scientific Meeting ofAmerican College of Rheumatology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-11-08
    • Data Source
      KAKENHI-PROJECT-23791256
  • [Presentation] 転写因子Fli1がI型コラーゲンの転写抑制因子として機能する機序2011

    • Author(s)
      浅野善英
    • Organizer
      強皮症班会議・強皮症研究会議合同会議
    • Place of Presentation
      東京
    • Year and Date
      2011-01-15
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Presentation] Themechanism of impaired wound healing in animal models with increased vascular senescence2011

    • Author(s)
      Asano Y, Trojanowska M, Sato S
    • Organizer
      The 36th annual meeting of the JSID
    • Place of Presentation
      Kyoto, JAPAN
    • Year and Date
      2011-12-08
    • Data Source
      KAKENHI-PROJECT-23791256
  • [Presentation] The mechanism of impaired wound healing in animal models with increased vascular senescence2011

    • Author(s)
      Yoshihide Asano, Maria Trojanowska, Shinichi Sato.
    • Organizer
      The 36th annual meeting of the JSID
    • Place of Presentation
      Kyoto, JAPAN
    • Data Source
      KAKENHI-PROJECT-23791256
  • [Presentation] 転写因子Fli1がangiogenesisにおける血管内皮細胞の動態に及ぼす影響2010

    • Author(s)
      浅野善英
    • Organizer
      強皮症班会議・強皮症研究会議合同会議
    • Place of Presentation
      塩野義製薬(東京都)
    • Year and Date
      2010-01-16
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Presentation] The role of transcription factor Fli1 in the mechanism of fibrosis and vasculopathy in systemic sclerosis and a new therapeutic strategy targeting this transcription factor2010

    • Author(s)
      Asano Y.
    • Organizer
      4th Annual Symposium in Institute of Dermatological Science (Seoul National University)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-02-05
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Presentation] The impact of transcription factor Fli1 on the regulation of angiogenesis2010

    • Author(s)
      Yoshihide Asano
    • Organizer
      Japanese Society for Investigative Dermatology
    • Place of Presentation
      Wakayama
    • Year and Date
      2010-12-03
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Presentation] The impact of transcription factor Fli1 on the regulation of angiogenesis.2010

    • Author(s)
      Asano Y, Trojanowska M.
    • Organizer
      The 35th Annual Meeting of the JSID
    • Place of Presentation
      Wakayama, Japan
    • Year and Date
      2010-12-03
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Presentation] The impact of transcription factor Fli1 on the regulation of angiogenesis.2010

    • Author(s)
      Yoshihide Asano.
    • Organizer
      Japanese Society for Investigative Dermatology.
    • Place of Presentation
      和歌山
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Presentation] Endothelial Fli1 deficiency impairs vascular homeostasis : a role in scleroderma vasculopathy.2009

    • Author(s)
      Asano Y, Stawski L, Hant F, Highland K, Silver R, Szalai G, Watson DK,Trojanowska M.
    • Organizer
      Japanese Society for Investigative Dermatology.
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-21791063
  • [Presentation] Fasudil ameliorates fibrosis, vasculopathy, and immune abnormalities in animal models of systemic sclerosis

    • Author(s)
      Tetsuo Toyama, Yoshihide Asano, Kouki Nakamura, Takashi Yamashita, Ryosuke Saigusa, Takehiro Takahashi, Yohei Ichimura, Takashi Taniguchi, Ayumi Yoshizaki, Maria Trojanowska, Shinichi Sato, Takafumi Kadono.
    • Organizer
      The 39th Annual Meeting of the Japanease Society for Investigative Dermatology
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2014-12-12 – 2014-12-14
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Presentation] Am80 ameliorates bleomycin-induced dermal fibrosis by suppressing the pro-fibrotic phenotype of fibroblasts, endothelial cells, and immune cells.

    • Author(s)
      Tetsuo Toyama, Yoshihide Asano, Ryosuke Saigusa, Takehiro Takahashi, Yohei Ichimura, Takashi Taniguchi, Shinji Noda, Kaname Akamata, Koichi Shudo, Shinichi Sato, Takafumi Kadono.
    • Organizer
      The 2014 American College of Rheumatology Annual Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2014-11-13 – 2014-11-18
    • Data Source
      KAKENHI-PROJECT-25461663
  • [Presentation] Myeloid Fli1 deficiency induces tissue fibrosis, vasculopathy, and immune abnormalities recapitulating systemic sclerosis

    • Author(s)
      Takashi Taniguchi, Yoshihide Asano, Kaname Akamata, Shinji Noda, Takehiro Takahashi, Yohei Ichimura, Tetsuo Toyama, Ryosuke Saigusa, Ayumi Yoshizaki, Maria Trojanowska, Shinichi Sato.
    • Organizer
      The 39th Annual Meeting of the Japanease Society for Investigative Dermatology
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2014-12-12 – 2014-12-14
    • Data Source
      KAKENHI-PROJECT-25461663
  • []

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  • 1.  SATO Shinichi (20215792)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 33 results
  • 2.  Trojanowska Maria
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  KADONO Takafumi (80292910)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  Oka Akira (80384866)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  Zhuang Yuan
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  YOSHIZAKI Ayumu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 7.  ITO Taichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  谷口 隆志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  高橋 岳浩
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  深澤 毅倫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  川畑 仁人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  太田 誠一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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