YOSHIMURA Kazuhisa 吉村和久

… Alternative Names

吉村和久ヨシムラカズヒサ

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Researcher Number	60315306
Affiliation (Current)	2025: 東京都健康安全研究センター, 企画調整部, 所長
Affiliation (based on the past Project Information) *help	2013 – 2014: 国立感染症研究所, その他部局等, その他 2012 – 2014: 国立感染症研究所, エイズ研究センター, 室長 2010 – 2011: Kumamoto University, エイズ学研究センター, 准教授 2008 – 2009: Kumamoto University, エイズ学研究センター, 講師 2000 – 2004: 熊本大学, エイズ学研究センター, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / Infectious disease medicine / 内科学一般 Except Principal Investigator Virology
Keywords	Principal Investigator HIV-1 / proviral DNA / turnover / HAART / CD4^+ T cell / residual replication / gp120 / 中和抗体 / animal model / antiretroviral therapy … More / Turnover / NBD誘導体 / Envelope / subtype non-B / 侵入阻害剤 / CD4 mimic / envelope / Betulinic acid / entry inhibitors / エンベロープ / 中和抗体増強剤 / NBD-556 / 低分子化合物 / memory CD8+ T cell / SHIV89.6P / memory CD8^+ T cells / SHIV_<89.6P> / リンパ球ターンオーバー / 経口投与 / マカクサルモデル / SHIV / 臨床応用 / 新規耐性変異 / 多剤耐性ウイルス / UIC-94003 / プロテアーゼ阻害剤 … More Except Principal Investigator リガンド / 2量体化 / 補助受容体 / オリゴマー形成 / HIV / モノマー / オリゴマー / CCR5 / HIV-1 Less

Development of novel entry inhibitors with inducing conformational change of Non-B HIV-1 envelope.Principal Investigator
- Principal Investigator
  
  YOSHIMURA Kazuhisa
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  National Institute of Infectious Diseases
The role of CCR5 oligomerization in the entry of CCR5-using HIV-1
- Principal Investigator
  
  MAEDA Yosuke
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kumamoto University
Analysis for a mechanism of anti-HIV-1 neutralizing antibody enhancement by a novel low molecular weight compound.Principal Investigator
- Principal Investigator
  
  YOSHIMURA Kazuhisa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
サルを用いたHAARTと免疫療法の前臨床動物モデルの確立Principal Investigator
- Principal Investigator
  
  吉村和久
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
サルを用いたHAARTと免疫療法の前臨床動物モデルの確立Principal Investigator
- Principal Investigator
  
  吉村和久
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Evaluation of residual viral replication by proviral DNA level and T cell turnover for optimization of HAART.Principal Investigator
- Principal Investigator
  
  YOSHIMURA Kazuhisa
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Kumamoto University
サルを用いたHAARTと免疫療法の前臨床動物モデルの確立Principal Investigator
- Principal Investigator
  
  吉村和久
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
新規抗HIV剤の開発と薬剤耐性のメカニズムの解析Principal Investigator
- Principal Investigator
  
  吉村和久
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内科学一般
- Research Institution
  Kumamoto University

All 2015 2014 2013 2012 2011 2010 2009 2008 2003 2002 Other

All Journal Article Presentation

[Journal Article] Passive transfer of neutralizing monoclonal antibody KD-247reduces plasma viral load in patients chronically infected with HIV-1.2015
- Author(s)
  Matsushita, S., Yoshimura, K., Ramirez, K.P., Pisupati, J., Murakami, T.
- Journal Title
  
  AIDS
  
  Volume: 29 Issue: 4 Pages: 453-462
- DOI
  10.1097/qad.0000000000000570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains.2015
- Author(s)
  Ramirez, K.P., Kuwata, T., Maruta, Y, Tanaka K., Muntasir, A., Yoshimura, K., Matsushita, S.
- Journal Title
  
  Virology
  
  Volume: 475 Pages: 187-203
- DOI
  10.1016/j.virol.2014.11.011
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-26430091
[Journal Article] Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247.2015
- Author(s)
  Kirby, K.A., Ong Y.T., Hachiya, A., Laughlin, T.G.,Chiang, L.A., Pan Y., Moran, J.L., Marchand, B.,Singh, K., Gallazzi, F., Quinn, T.P., Yoshimura, K., Murakami, T., Matsushita S., Sarafianos, S.G.
- Journal Title
  
  The FASEB Journal
  
  Volume: 29 Issue: 1 Pages: 1-11
- DOI
  10.1096/fj.14-252262
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] Impact of maraviroc-resistant and low-CCR5- adapted mutations induced by in vitro passage on sensitivity to anti-envelope neutralizing antibodies.2014
- Author(s)
  Kazuhisa Yoshimura, Shigeyoshi Harada, Samatchaya Boonchawalit, Yoko Kawanami, Shuzo Matsushita.
- Journal Title
  
  Journal of General Virology
  
  Volume: 95 Issue: 8 Pages: 1816-1826
- DOI
  10.1099/vir.0.062885-0
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] A CD4 Mimic as an HIV Entry Inhibitors: Pharmacokinetics2013
- Author(s)
  Hashimoto, C., Narumi, T., Otsuki, H., Hirota, Y., Arai, H., Yoshimura, K., Harada, S., Ohashi, N., Nomura, W., Miura, T., Igarashi, T., Matsuhita, S., Tamamura, H.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 21 Issue: 24 Pages: 7884-7889
- DOI
  10.1016/j.bmc.2013.10.005
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24105507, KAKENHI-PUBLICLY-24119506, KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-24659043, KAKENHI-PROJECT-24790107, KAKENHI-PROJECT-25410171
[Journal Article] Impact of antiretroviral pressure on selection of primary human immunodeficiency virus type 1 envelope sequences in vitro.2013
- Author(s)
  Shigeyoshi Harada, Kazuhisa Yoshimura, Aki Yamaguchi, Samatchaya Boonchawalit, Keisuke Yusa, Shuzo Matsushita.
- Journal Title
  
  Journal of General Virology
  
  Volume: 94 Issue: 5 Pages: 933-943
- DOI
  10.1099/vir.0.047167-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] Conformational epitope consisting of the V3 and V4 loops as a target for potent and broad neutralization of simian immunodeficiency viruses.2013
- Author(s)
  Kuwata T
- Journal Title
  
  J Virol.
  
  Volume: in press Issue: 10 Pages: 933-943
- DOI
  10.1128/jvi.00201-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500387, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PUBLICLY-25115519
[Journal Article] CD4 Mimics as HIV Entry Inhibitors: Lead Optimization Studies of the Aromatic Substituents.2013
- Author(s)
  Narumi, T., Arai, H., Yoshimura, K., Harada, S., Hirota, Y., Ohashi, N., Hashimoto, C.. Nomura, W., Matsushita, S. and Tamamura, H.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 8 Issue: 9 Pages: 2518-2526
- DOI
  10.1016/j.bmc.2013.02.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05127, KAKENHI-PUBLICLY-24105507, KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-24659043, KAKENHI-PROJECT-24790107
[Journal Article] Generation of a replication-competent simianhuman immunodeficiency virus, the neutralisation sensitivity of which can be enhanced in the presence of a small molecule CD4 mimic.2013
- Author(s)
  Otsuki, H., Hishiki, T., Miura, T., Hashimoto, C., Narumi, T., Tamamura, H., Yoshimura, K., Matsushita, S., and Igarashi, T.
- Journal Title
  
  J. Gen. Virol.
  
  Volume: 94 Issue: 12 Pages: 2710-2716
- DOI
  10.1099/vir.0.055590-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658240, KAKENHI-PUBLICLY-24105507, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-24659043, KAKENHI-PROJECT-24790107
[Journal Article] Increased infectivity in human cells and resistance to antibody-mediated neutralization by truncation of the SIV gp41 cytoplasmic tail.2013
- Author(s)
  8. Kuwata, T.
- Journal Title
  
  Frontiers in Microbiology/Virology.
  
  Volume: 4 Pages: 1-7
- DOI
  10.3389/fmicb.2013.00117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] Structural Dynamics of HIV-1 Envelope Gp120 Outer Domain with V3 Loop.2012
- Author(s)
  Yokoyama M, Naganawa S, Yoshimura K, Matsushita S, Sato H
- Journal Title
  
  PLoS ONE
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591485
[Journal Article] Preparation of biologically active single-chain variable antibody fragments that target the HIV-1 gp120 V3 loop.2012
- Author(s)
  Ong YT, Kirby KA, Hachiya A, Chiang LA, Marchand B, Yoshimura K, Murakami T, Singh K, Matsushita S, Sarafianos SG
- Journal Title
  
  Cellular and Molecular Biology
  
  Volume: 58 Pages: 71-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591485
[Journal Article] In vitro and In vivo Resistance to Human Immunodeficiency Virus Type 1 Entry Inhibitors2011
- Author(s)
  Maeda, Y.
- Journal Title
  
  J AIDS Clinic Res
  
  Volume: in press Issue: S2
- DOI
  10.4172/2155-6113.s2-004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790163, KAKENHI-PROJECT-23590548
[Journal Article] CD4 mimics targeting the mechanism of HIV entry.2010
- Author(s)
  Yamada, Y., Ochiai, C., Yoshimura, K., Tanaka, T., Ohashi, N., Narumi, T., Nomura, W., Harada, S., Matsushita, S., Tamamura, H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 20
  
  Pages: 354-358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] HIV-1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V2.2010
- Author(s)
  Hatada, M., Yoshimura, K., Harada, S., Kawanami, Y., Shibata, J., Matsushita, S.
- Journal Title
  
  J Gen Virol 91
  
  Pages: 1335-1345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds.2010
- Author(s)
  Yoshimura, K., Harada, S., Shibata, J., Hatada, M., Yamada, Y., Ochiai, C., Tamamura, H., Matsushita, S.
- Journal Title
  
  J Virol 84
  
  Pages: 7558-7568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds.2010
- Author(s)
  Yoshimura, K.
- Journal Title
  
  J.Virol.
  
  Volume: 84 Pages: 7558-7568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] CD4mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist.2010
- Author(s)
  Narumi, T., Ochiai, C., Yoshimura, K., Harada, S., Tanaka, T., Nomura, W., Arai, H., Ozaki, T., Ohashi, N., Matsushita, S., Tamamura, H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 20
  
  Pages: 5853-5858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] Non-cleavage site gag mutations in amprenavir-resistant HIV-1 predispose HIV-1 to rapid acquisition of amprenavir resistance but delays development of resistance to other protease Inhibitors.2009
- Author(s)
  Aoki, M., Venzon, D.J., Koh, Y., Aoki-Ogata, H., Miyakawa, T., Yoshimura, K., Maeda, K., Mitsuya, H.
- Journal Title
  
  J Virol. 83
  
  Pages: 3059-3068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] SOCS1 is an inducible host factor during HIV-1 infection the intracellular trafficking and stability of HIV-1 Gag.2008
- Author(s)
  Ryo, A., Tsurutani, N., Ohba, K., Kimura, R., Komano, J., Nishi, M., Soeda, H., Hattori, S., Perrem, K., Yamamoto, M., Chiba, J., Mimaya, J., Yoshimura, K., Matsushita, S., Honda, M., Yoshimura, A., Sawasaki, T., Aoki, I., Morikawa, Y., Yamamoto, N.
- Journal Title
  
  Proc Natl Acad Sci USA. 105
  
  Pages: 294-299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591206
[Journal Article] The impact of highly active antiretroviral therapy by the oral route on the CD8 subset in monkeys infected chronically with SHIV89.6P.2003
- Author(s)
  Yoshimura, K
- Journal Title
  
  J.Virol.Methods. 112
  
  Pages: 121-128
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570422
[Journal Article] A potent protease inhibitor(PI) UIC-94003 interacting with main chains of HIV protease active site amino acids and the development of a novel mutation A28S in the protease of UIC-94003-resistant HIV.2002
- Author(s)
  Yoshimura, K
- Journal Title
  
  J.Virol. 78
  
  Pages: 12030-12040
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570422
[Journal Article] A Potent Protease Inhibitor (PI) UIC-94003 Interacting with Main Chains of HIV Protease Active Site Amino Acids and the Development of a Novel Mutation A28S in the Protease of UIC-94003-Resistant HIV.2002
- Author(s)
  Yoshimura, K
- Journal Title
  
  J.Virol 76
  
  Pages: 1349-1358
- Data Source
  KAKENHI-PROJECT-14570422
[Journal Article] A Potent Protease Inhibitor (PI) UIC-94003 Interacting with Main Chains of HIV Protease Active Site Amino Acids and the Development of a Novel Mutation A28S in the Protease of UIC-94003-Resistant HIV.2002
- Author(s)
  Yoshimura, K
- Journal Title
  
  J.Virol. 76
  
  Pages: 1349-1358
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570422
[Presentation] Impact of CD4 mimetics-resistant mutations on susceptibilities to anti-Env nMAbs.2014
- Author(s)
  Shigeyoshi Harada, Samatchaya Boonchawalit, Tetsuo Narumi, Hirokazu Tamamura, Shuzo Matsushita, Kazuhisa Yoshimura
- Organizer
  21th Conference on Retroviruses and Opportunistic Infections (CROI2014)
- Place of Presentation
  Boston (USA)
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] 抗V3抗体および低分子CD4ミミック曝露後投与によるアカゲザルでのSHIV複製抑制2013
- Author(s)
  大附寛幸,丸田泰広,橋本智恵,鳴海哲夫,廣田雄樹, 原田恵嘉, 三浦智行, 吉村和久,玉村啓和,松下修三, 五十嵐樹彦
- Organizer
  第27回日本エイズ学会学術集会・総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] CD4 mimic small compounds, NBD-556 and its analogues bind at three amino acid positions in the gp120 CD4 cavity.2013
- Author(s)
  Harada S, Boonchawalit S, Narumi T, Tamamura H, Matsushita S, Yoshimura K
- Organizer
  20th Conference on Retroviruses and Opportunistic Infections (CROI 2013)
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Analysis of interaction between gp120 and CD4 mimic small compounds that enhance the activity of anti-HIV neutralizing antibodies.2013
- Author(s)
  Shigeyoshi Harada, Samatchaya Boonchawalit, Shuzo Matsushita, Kazuhisa Yoshimura
- Organizer
  AIDS Vaccine 2013
- Place of Presentation
  Barcelona (Spain)
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Impact of Maraviroc-resistant and low CCR5-adapted mutations induced in vitro passage on sensitivity to anti-Env neutralizing antibodies.2013
- Author(s)
  Yoshimura K, Harada S, Boonchawalit S, and Matsushita S
- Organizer
  20th Conference on Retroviruses and Opportunistic Infections (CROI 2013)
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] バルクおよびクローンウイルスを用いたCD4類似低分子化合物誘導体に対するin vitro 耐性ウイルス誘導2013
- Author(s)
  原田恵嘉, 鳴海哲夫, Samatchaya Boonchawalit, 玉村啓和, 松下修三, 吉村和久
- Organizer
  第27回日本エイズ学会学術集会・総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] In vitro selection of bifunctional CD4 mimic small compounds (NBD analogues) using bulk and cloned primary isolates.2013
- Author(s)
  原田恵嘉, Samatchaya Boonchawalit, 松下修三, 吉村和久
- Organizer
  第15回白馬シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Indole-type small CD4 mimic molecules targeting an HIV envelope protein gp120.2013
- Author(s)
  Yuki Hirota, Tetsuo Narumi, Kazuhisa Yoshimura, Shigeyoshi Harada, Chie Hashimoto, Wataru Nomura, Tatsuhiko Igarashi, Shuzo Matsushita, Hirokazu Tamamura
- Organizer
  14th Kumamoto AIDS Seminar
- Place of Presentation
  Kumamoto (Japan)
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] HIV外被タンパク質gp120を標的とするインドール型低分子CD4ミミックの創製研究2012
- Author(s)
  廣田雄樹、鳴海哲夫、橋本智恵、吉村和久、原田恵嘉、大附寛幸、三浦智行、五十嵐樹彦、相川春夫、野村渉、松下修三、玉村啓和
- Organizer
  第26回日本エイズ学会学術集会・総会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] In vitro induction of ten CD4 mimic small compounds, NBD-556 and its analogues, resistant variants using primary R5 HIV-1.2012
- Author(s)
  Harada S, Arai H, Narumi T, Tamamura H, Matsushita S, Yoshimura K
- Organizer
  19th International AIDS Conference
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] R5臨床分離株を用いた10種のCD4類似低分子化合物に対するin vitro 耐性ウイルス誘導2012
- Author(s)
  原田恵嘉、新井　啓之、鳴海　哲夫、玉村　啓和、松下修三、吉村和久
- Organizer
  第14回白馬シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] CCR5阻害剤による耐性変異と中和抗体感受性2012
- Author(s)
  吉村和久
- Organizer
  第14回白馬シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] SIV感染サルから分離された中和抗体B404はV3,V4ループを含むEnv立体構造を認識する2012
- Author(s)
  桑田岳夫、吉村和久、松下修三
- Organizer
  第26回日本エイズ学会学術集会・総会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] In vitro induction of twelve CD4 mimic small compounds, NBD-556 and its analogues, resistant variants using primary R5 HIV-1.2012
- Author(s)
  Harada S, Boonchawalit S, Narumi T, Tamamura H, Matsushita S, Yoshimura K
- Organizer
  13th Kumamoto AIDS Seminar GCOE Joint International Symposium,
- Place of Presentation
  Kumamoto, Japan
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] R5臨床分離株を用いたCD4類似低分子化合物誘導体に対するin vitro耐性ウイルス誘導2012
- Author(s)
  原田恵嘉、鳴海　哲夫、玉村　啓和、松下修三、吉村和久
- Organizer
  第26回日本エイズ学会学術集会・総会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Two step escape pathway of the HIV-1 subtype C primary isolate induced by the in vitro selection of Maraviroc.2010
- Author(s)
  Yoshimura K., Harada S., Matsushita S.
- Organizer
  17h Conference on Retroviruses and Opportunistic Infections (CROI 2010)
- Place of Presentation
  Moscone Center West, San Francisco, USA.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Evolution and selection of the env gene of HIV-1 primary isolates during in vitro selection of raltegravir.2010
- Author(s)
  Harada S., Hamji A., Matsushita S., Yoshimura K.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Aso Resort Grandvrio Hotel, Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Two step escape pathway of the HIV-1 subtype C primary isolate induced by the in vitro selection of Maraviroc2010
- Author(s)
  吉村和久
- Organizer
  17h Conference on Retroviruses and Opportunistic Infections(CROI 2010)
- Place of Presentation
  Moscone Center West, San Francisco, USA
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Impact of a point mutation in V2 (L175P) in neutralization resistance mediated by functional trimer formation of Env.2010
- Author(s)
  Liu M., Shibata J., Harada S., Takehisa J., Yoshimura K., Matsushita S.
- Organizer
  AIDS Vaccine 2010
- Place of Presentation
  The Omni Hotel at CNN Center, Atlanta, USA.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] In vitro selections of raltegravir resistant variants using diverse primary isolates, subtype B, C, CRFO1_AE, and CRFO8_BC.2010
- Author(s)
  Harada S., Yoshimura K., Kawanami Y., Matsushita S.
- Organizer
  2010 IYIS
- Place of Presentation
  The Center for AIDS Research, Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] CD4 mimetic compound-mediated enhancement of the neutralization activities of anti-V3 and CD4i monoclonal antibodies against the standard panel of primary isolates.2010
- Author(s)
  Matsushita S., Mouri S., Harada S., Yamada Y., Tamamura H., Yoshimura K.
- Organizer
  XVIII International AIDS conference
- Place of Presentation
  The Reed Messe Wien, Vienna, Austria.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Mechanism of maintaining a glycan-insertion in HIV-1 gp120 V2 region under pressure of a potent neutralizing antibody in vitro.2009
- Author(s)
  Matsushita S., Narahara C., Nishida Y., Honda A., Harada S., Yoshimura K.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Mutations in V4 and C4 regions of the HIV-1 CRF-BC envelope induced by the in vitro selection of Maraviroc Confer cross-resistance to other CCR5 inhibitors.2009
- Author(s)
  Yoshimura, K.
- Organizer
  16th Conference on Trtroviruses and Opportunistic Infections (CROI 2009)
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] In vitro induction of HIV-1 resistant to a CCR5 antagonist maraviroc.2009
- Author(s)
  Yoshimura K., Harada S., Hatada M., Matsushita S.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Mutations in gp120 of R5 HIV-1 laboratory isolate induced by the in vitro selection of maraviroc confer highly sensitive to anti-V3 monoclonal antibody.2009
- Author(s)
  Ishikawa T., Yoshimura K., Hatada M., Harada S., Matsushita S.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Generation of an integrase inhibitor raltegravir resistant variants using recent primary isolates, X4, R5 and dual/mix HIV-1.2009
- Author(s)
  Harada S., Yoshimura K., Matsushita S.
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Mutations in V4 and C4 regions of the HIV-1 CRFO8-BC envelope induced by the in vitro selection of Maraviroc Confer cross-resistance to other CCR5 inhibitors.2009
- Author(s)
  Yoshimura K., Harada S., Hatada M., Matsushita S.
- Organizer
  16th Conference on Retroviruses and Opportunistic Infections (CROI 2009)
- Place of Presentation
  Palais des Congres de Montreal, Montreal, Canada.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] In vitro induction of HIV-1 resistant to a CCR5 antagonist maraviroc2009
- Author(s)
  吉村和久
- Organizer
  10th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Hotel Nikko kumamoto, Kumamoto, Japan
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] ケモカインレセプター阻害剤の臨床的研究～臨床分離株を用いたマラビロック耐性誘導～2009
- Author(s)
  吉村和久
- Organizer
  第23回日本エイズ学会学術集会・総会
- Place of Presentation
  名古屋国際会議場、名古屋
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] A primary R5 isolate undergoes different escape pathway during in vitro selection with low or high concentration of an anti-V3 monoclonal antibody.2009
- Author(s)
  Narahara C., Hatada M., Harada S., Yoshimura K., Matsushita S.
- Organizer
  AIDS Vaccine 2009 Conference
- Place of Presentation
  Marriott Rive Gauche Conference Center, Paris, France.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] In vitro induction of HIV-1 resistant to a CCR5.2009
- Author(s)
  Yoshimura K., Matsushita S.
- Organizer
  Kumamoto AIDS Seminar GCOE Joint InternationalSymposium-Satellite Symposium
- Place of Presentation
  Aso Resort Grandvrio Hotel, Kumamoto, Japan.
- Year and Date
  2009-09-30
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Polyclonal antibody response against gp120 including antibodies to V3, CD4bs and CD4i epitopes account or broad neutralization.2009
- Author(s)
  Matsushita S., Narahara C., Morizono M., Nishida Y., Honda-Shibata A., Harada S., Yoshimura, K.
- Organizer
  5th Conference on HIV Pathogenesis, Treatment and Prevention
- Place of Presentation
  The Cape Town International Convention Centre, Cape Town, South Africa.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Different mutation in HIV-1 gp120 V3-tip region for escape from a potent neutralizing anti-V3 monoclonal antibody during in vitro selection with low or high concentration of the Mab.2008
- Author(s)
  Narahara C., Yoshimura K., Hatada M., Harada S., Matsushita S.
- Organizer
  9th Kumamoto AIDS Seminar
- Place of Presentation
  Aso Resort Grandvrio Hotel, Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] CD4 mimic small compound のin vitro耐性誘導による結合部位の予測2008
- Author(s)
  吉村和久
- Organizer
  第22回日本エイズ学会学術集会・総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] The impact of an N-linked glycosylation site insertion in HIV-1 gp120 region to escape from a potent neutralization anti-V3 monoclonal antibody.2008
- Author(s)
  Hatada M., Yoshimura K., Ishikawa T., Harada S., Matsushita S.
- Organizer
  9th Kumamoto AIDS Seminar
- Place of Presentation
  Aso Resort Grandvrio Hotel Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] In vitro induction of human immunodeficiency virus type 1 variants resistant to a low-molecular CD4 mimic compound.2008
- Author(s)
  Yoshimura K., Hatada M., Harada S., Shibata J., Masuno H., Tamamura H., Matsushita S.
- Organizer
  9th Kumamoto AIDS Seminar
- Place of Presentation
  Aso Resort Grandvrio Hotel, Kumamoto, Japan.
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] In vitro induction of human immunodeficienby virus type 1 variants resistant to a low-molecular CD4 mimic compound.2008
- Author(s)
  Yoshimura, K.
- Organizer
  9^<th> Kumamoto AIDS Seminar.
- Place of Presentation
  Kumamoto
- Year and Date
  2008-09-18
- Data Source
  KAKENHI-PROJECT-20591206
[Presentation] Impact of Maraviroc (MVC)-resistant mutations in C1 and C4 regions of gp120 on sensitivity to antibody-mediated neutralization.
- Author(s)
  Samatchaya Boonchawalit, Shigeyoshi Harada, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  20th International AIDS Conference
- Place of Presentation
  Melbourne (Australia)
- Year and Date
  2014-07-20 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Resistance Profile of CD4 Mimic Small Compounds (CD4MCs) and the Structure Analysis by Molecular Dynamic (MD) Simulation.
- Author(s)
  Shigeyoshi Harada, Masaru Yokoyama, Samatchaya Boonchawalit, Hironori Sato, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  HIV Research For Prevention (HIVR4P) 2014
- Place of Presentation
  Cape Town (South Africa)
- Year and Date
  2014-10-28 – 2014-10-31
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Mutations at the bottom of the Phe43 cavity are responsible for cross-resistance to NBD analogues.
- Author(s)
  Shigeyoshi Harada, Yu Irahara, Samatchaya Boonchawalit, Mai Goryo, Hirokazu Tamamura, Tetsuro Matano, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  The annual Conference on Retroviruses and Opportunistic Infections (CROI) 2015
- Place of Presentation
  Seattle (USA)
- Year and Date
  2015-02-23 – 2015-02-26
- Data Source
  KAKENHI-PROJECT-24591485
[Presentation] Impact of the Drug-Escaped HIV Envelope Mutations on Susceptibility to Neutralizing Antibodies.
- Author(s)
  Kazuhisa Yoshimura.
- Organizer
  17th International Conference on Emerging Infectious Diseases (EID), AIDS Panel Meeting
- Place of Presentation
  Taipei (Taiwan)
- Year and Date
  2015-01-28 – 2015-01-29
- Invited
- Data Source
  KAKENHI-PROJECT-24591485

1. MAEDA Yosuke (30284764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. HARADA Shinji (60173085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 松下修三 (00199788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. NARUMI Tetsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. HARADA Shigeyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. KUWATA Takeo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 三浦智行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOSHIMURA Kazuhisa 吉村 和久

吉村 和久 ヨシムラ カズヒサ

Research Projects

Research Products

Co-Researchers

Development of novel entry inhibitors with inducing conformational change of Non-B HIV-1 envelope.Principal Investigator

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The role of CCR5 oligomerization in the entry of CCR5-using HIV-1

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Analysis for a mechanism of anti-HIV-1 neutralizing antibody enhancement by a novel low molecular weight compound.Principal Investigator

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サルを用いたHAARTと免疫療法の前臨床動物モデルの確立Principal Investigator

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サルを用いたHAARTと免疫療法の前臨床動物モデルの確立Principal Investigator

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Evaluation of residual viral replication by proviral DNA level and T cell turnover for optimization of HAART.Principal Investigator

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サルを用いたHAARTと免疫療法の前臨床動物モデルの確立Principal Investigator

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新規抗HIV剤の開発と薬剤耐性のメカニズムの解析Principal Investigator

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[Journal Article] Passive transfer of neutralizing monoclonal antibody KD-247reduces plasma viral load in patients chronically infected with HIV-1.2015

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[Journal Article] Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains.2015

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[Journal Article] Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247.2015

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[Journal Article] Impact of maraviroc-resistant and low-CCR5- adapted mutations induced by in vitro passage on sensitivity to anti-envelope neutralizing antibodies.2014

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[Journal Article] A CD4 Mimic as an HIV Entry Inhibitors: Pharmacokinetics2013

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[Journal Article] Impact of antiretroviral pressure on selection of primary human immunodeficiency virus type 1 envelope sequences in vitro.2013

Author(s)

YOSHIMURA Kazuhisa 吉村和久

吉村和久ヨシムラカズヒサ