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YAMAGUCHI Koji  山口 浩司

ORCIDConnect your ORCID iD *help
Researcher Number 60315512
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2007 – 2008: Sapporo Medical University, 医学部, 助教
2005 – 2007: 札幌医科大学, 医学部, 助手
2006: Sapporo Medical University, School of Medicine, Assistant Professor, 医学部, 講師
2000 – 2003: 札幌医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Digestive surgery / Digestive surgery
Except Principal Investigator
General surgery / General surgery
Keywords
Principal Investigator
リンパ節転移 / 同所性移植 / 胃癌 / DNAマイクロアレイ / VEGF-C遺伝子 / 肝転移 / cDNA microarray / lymph node metastasis / VEGF-C gene / orthotopic implantation … More / gastric cancer / gastric carcinoma / peritoneal dissemination / liver metastasis / ymph node metastasis / orthotopic implantatiopn / 接着分子 / ヌードマウス / 胃癌細胞株 / 腹膜転移 / 同所性転移 / 癌 … More
Except Principal Investigator
ELISPOT assay / Tetramer staining / IFN-a / 癌ペプチド / 癌 / survivin-2B / pentide vaccine therapy / peptide / immunotherapy / cancer / 評価 / MHCクラスI / サバイビン2B / ペプチドワクチン療法 / ペプチド / 免疫療法 / omega-3 fattv acid / Intracellular cytokine staining / Cytokine / Monocyte / T-lymphocyte / Th2 balance / Thl / Cellular immunity / Bodily insult / 感染症 / ω-3系脂肪酸 / 細胞内サイトカイン測定 / サイトカイン / 単球 / T細胞 / Th2バランス / Th1 / 細胞性免疫 / 生体侵襲 / 治療 / 逃避機構 / 免疫 / ワクチン / MHC class I / Tetramer / 大腸がん / 乳がん / 特異的免疫療法 / サバイビン / 適応 / ペプチドワクチン Less
  • Research Projects

    (8 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (13 People)
  •  免疫逃避克服による新規癌ペプチドワクチン療法の確立

    • Principal Investigator
      平田 公一
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General surgery
    • Research Institution
      Sapporo Medical University
  •  The analysis of the gene cluster and biological function about the gastric cancer cell lines highly metastatic to liver and lymph node metastasisPrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Koji
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Sapporo Medical University
  •  高い有効性を誘導するための新たなる癌ペプチドワクチン療法適応決定因子の確立

    • Principal Investigator
      HIRATA Koichi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General surgery
    • Research Institution
      Sapporo Medical University
  •  Cancer Immunotherapy, targets Survivin, and Establishment of Evaluation Methods of Therapeutic Effects

    • Principal Investigator
      TSURUMA Tetsuhuro
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Sapporo Medical University
  •  Clarification of the lymph node metastasis mechanism by orthotopic implantation models and application to inhibition of the metastasisPrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Koji
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Sapporo Medical University
  •  ヒト胃癌細胞株を用いたリンパ節転移機序の解析と転移阻害治療法の開発Principal Investigator

    • Principal Investigator
      山口 浩司
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Sapporo Medical University
  •  Changes of Thl/Th2 balance and serum cytokine levels in critically ill patients.

    • Principal Investigator
      URA Hideki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Sapporo Medical University
  •  Establishment and Characterization of Highly Metastatic Human Gastric Carcinoma Cell Line Established by Orthotopic Tumor Cell ImplantationPrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Koji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Sapporo Medical University

All 2008 2007 2006 2005

All Journal Article Presentation

  • [Journal Article] Clinical, Immunological Evaluation of Anti-apoptosis Protein, Survivin-derived Peptide Vaccine in Phase I Clinical Study for Patients with Advanced or Recurrent Breast Cancer2008

    • Author(s)
      Tsuruma, T., Iwayama, Y., Katsuramaki, T., Hata, F., Furuhata, T., Yamaguchi, K., Kimura, Y., Torigoe, T., Toyota, N., Yagihashi, A., Hirohashi, Y., Asanuma, H., Shimozawa, K., Okazaki, M., Mizushima, Y., Nomura, N., Sato, N., Hirata, K
    • Journal Title

      J Transl Med 10

      Pages: 24-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Journal Article] Clinical and Immunological Evaluation of Anti-apoptosis Protein,Survivin-derived Peptide Vaccine in Phase I CIinical Study for Patients with Advanced or Recurrent Breast Cancer2008

    • Author(s)
      Tsuruma T, Iwayama Y, KatsuramakiT, Hata F, Furuhata T, Yamaguchi K, Kimura Y, Torigoe T, Toyota N, Yagihashi A, Hirohashi Y, Asanuma H, Shimozawa K, Okazaki M, Mizushima Y, Nomura N, Sato N and Hirata K
    • Journal Title

      J Transl Med 10

      Pages: 24-24

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Journal Article] Clinical and immunological evaluation of anti-apoptosis protein, survivin-derived peptide vaccine in phase I clinical study for patients with advanced or recurrent breast cancer2008

    • Author(s)
      Tsuruma T, Iwayama Y, Ohmura T, Katsuramaki T, Hata F, Furuhata T, Yamaguchi K, Kimura Y, Torigoe T, Toyota N, Yagihashi A, Hirohashi Y, Asanuma H, Shimozawa K, Okazaki M, Mizushima Y, Nomura N, Sato N, Hirata K
    • Journal Title

      J Transl Med 6

      Pages: 24-24

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591550
  • [Journal Article] 「癌診療ガイドライン」の基本的理念と検証法2007

    • Author(s)
      平田 公一、古畑 智久、大村 東生、山口 浩司、木村 康利、太田 盛道
    • Journal Title

      消化器外科 30

      Pages: 1823-1836

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Journal Article] Phase I study of S-1, docetaxel and cisplatin combination chemotherapy in patients with unresectable metastatic gastric cancer2007

    • Author(s)
      Takayama T, Sato Y, Sagawa T, Okamoto T, Nagashima H, Takahashi Y, Ohnuma H, Kuroiwa G, Miyanishi K, Takimoto R, Matsunaga T, Kato J, Yamaguchi K, Hirata K, Niitsu Y
    • Journal Title

      Br J Cancer 97(7)

      Pages: 851-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591550
  • [Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer2007

    • Author(s)
      Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
    • Journal Title

      Oncogene 26(32)

      Pages: 4699-713

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591550
  • [Journal Article] The basic principle and validation approach of guideline of cancer treatment2007

    • Author(s)
      Hirata, K., Furuhata, T., Ohmura, T., Yamaguchi, K., Kimura, Y., Ohta, M
    • Journal Title

      Gastroenterological Surgery 30

      Pages: 1823-1836

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Journal Article] Plasma level of a 5-fluorouracil metabolite, fluoro-beta-alanine correlates with dihydropyrimidine dehydrogenase activity of peripheral blood mononuclear cells in 5-fluorouracil treated patients2006

    • Author(s)
      Furuhata T, Kawakami M, Okita K, Kimura Y, Kihara C, Tsuruma T, Ohmura T, Yamaguchi K, Hata F, Katsuramaki T, Sasaki K, Hirata K.
    • Journal Title

      J Exp Clin Cancer Res. 25(1)

      Pages: 79-82

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591422
  • [Journal Article] A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8-and caspase-9-mediated apoptosis2005

    • Author(s)
      Yamamoto M, Torigoe T, Kamiguchi K, Hirohashi Y, Nakanishi K, Nabeta C, Asanuma H, Tsuruma T, Sato T, Hata F, Ohmura T, Yamaguchi K, Kurotaki T, Hirata K, Sato N.
    • Journal Title

      Cancer Res. 65(19)

      Pages: 8706-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591422
  • [Journal Article] The interplay between gastric cancer cell lines and PBMCs mediated by the CC chemokine RANTES plays an important role in tumor progression.2005

    • Author(s)
      Okita K, Furuhata T, Kimura Y, Kawakami M, Yamaguchi K, Tsuruma T, embutsu H, Hirata K.
    • Journal Title

      J Exp Clin Cancer Res. 24(3)

      Pages: 439-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591422
  • [Presentation] 免疫監視機構からのエスケープによる予後規定因子:HLAクラスI発現について2007

    • Author(s)
      松村 将之、岩山 祐司、鶴間 哲弘、木村 康利、古畑 智久、大村 東生、山口 浩司、桂巻 正、鳥越 俊彦、佐藤 昇志、平田 公一
    • Organizer
      第28回癌免疫外科研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] Clinical study of Survivin-2B peptide vaccine therapy : the most suitable position of immunotherapy2007

    • Author(s)
      Iwayama, Y., Tsuruma, T., Furuhata, T., Yamaguchi, K., Ohmura, T., Kimura, Y., Torigoe, T., Sato, N
    • Organizer
      20th Annual Congress of Japan Society for Biological Therapy
    • Place of Presentation
      Sapporo
    • Year and Date
      2007-10-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] To establish cancer immune therapy : When shall we start immune therapy?2007

    • Author(s)
      Iwayama, Y., Furuhata, T., Ohmura, T., Yamaguchi, K., Mizuguchi, T., Kimura, Y., Tsuruma, T., Torigoe, T., Sato, N., Hirata, K
    • Organizer
      45th Annual Meeting of Japan Society of Clinical Oncology
    • Place of Presentation
      Osaka
    • Year and Date
      2007-10-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] A case of advanced pancreatic cancer that showed efficient clinical responses to survivin-peptide vaccine therapy2007

    • Author(s)
      岩山 祐司、鳥越 俊彦、古畑 智久、大村 東生、山口 浩司、水口 徹、木村 康利、鶴間 哲弘、高橋 あかり、佐藤 昇志、平田 公一
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] A case of advanced pancreatic cancer that showed efficient clinical responses to survivin-peptide vaccine therapy2007

    • Author(s)
      Iwayama, Y., Torigoe, T., Furuhata, T., Ohmura, T., Yamaguchi, K., Mizuguchi, T., Kimura, Y., Tsuruma, T., Takahashi, A., Sato, N., Hirata, K
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] HLA class I expression : a prognostic indicator by the escape from immune system2007

    • Author(s)
      Matsumura, M., Iwayama, Y., Tsuruma, T., Kimura, Y., Furuhata, T., Ohmura, T., Yamaguchi, K., Katsuramaki, T., Torigoe, T., Sato, N., Hirata, K
    • Organizer
      28th Japanese Research Society of Surgical Cancer Immunology
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-05-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] サバイビン2Bペプチドワクチン療法臨床試験〜免疫療法の最適な位置づけ2007

    • Author(s)
      岩山 祐司、鶴間 哲弘、古畑 智久、山口 浩司、大村 東生、木村 康利、鳥越 俊彦、佐藤 昇志
    • Organizer
      第20回日本バイオセラピイ学会学術集会総会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-11
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] がん免疫療法の確立化へむけて-免疫療法導入の最適時期は2007

    • Author(s)
      岩山 祐司、古畑 智久、大村 東生、山口 浩司、水口 徹、木村 康利、鶴間 哲弘、鳥越 俊彦、佐藤 昇志、平田 公一
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都
    • Year and Date
      2007-10-26
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] ペプチド療法および積極的外科切除にて長期生存している悪性黒色腫の1例2006

    • Author(s)
      鶴間 哲弘、古畑 智久、秦 史壮、川崎 浩之、澤田 健、山口 浩司、廣崎 邦紀、神保 孝一、平田 公一
    • Organizer
      第31回日本外科系連合学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2006-06-23
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] サバイビン2Bペプチドによるペプチドワクチン療法:免疫モニタリング、臨床効果判定法の確立化にむけて2006

    • Author(s)
      鶴間 哲弘、岩山 祐司、古畑 智久、山口 浩司、木村 康利、桂巻 正、下澤 久美子、鳥越 俊彦、佐藤 昇志、平田 公一
    • Organizer
      第27回癌免疫外科研究会
    • Place of Presentation
      北九州
    • Year and Date
      2006-06-01
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] Peptide vaccine therapy to induce anti-tumor effects : clinical study of survivin-2B peptide vaccine therapy2006

    • Author(s)
      Iwayama, Y., Tsuruma, T., Katsuramaki, T., Furuhata, T., Yamaguchi, K., Kimura, Y., Torigoe, T., Sato, N., Hirata, K
    • Organizer
      19th Annual Congress of Japan Society for Biological Therapy
    • Place of Presentation
      Fukuoka
    • Year and Date
      2006-12-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] Peptide vaccine therapy with survivin-2B peptide : To establish the immunological monitoring technique and the methods of estimation of clinical responses2006

    • Author(s)
      Tsuruma, T., Iwayama, Y., Furuhata, T., Yamaguchi, K., Kimura, Y., Katsuramaki, T., Shimozawa, K., Torigoe, T., Sato, N., Hirata, K
    • Organizer
      27th Japanese Research Society of Surgical Cancer Immunology
    • Place of Presentation
      Kita-kyushu
    • Year and Date
      2006-06-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] Stage ii大腸癌のHLA Class I発現異常と再発・予後因子との関係2006

    • Author(s)
      岩山 祐司、鶴間 哲弘、古畑 智久、大村 東生、山口 浩司、桂巻 正、秦 史壮、鳥越 俊彦、佐藤 昇志、平田 公一
    • Organizer
      第27回癌免疫外科研究会
    • Place of Presentation
      北九州
    • Year and Date
      2006-06-02
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] The relationship between HLA class I expression level and the factor of recurrence and prognosis2006

    • Author(s)
      Iwayama, Y., Tsuruma, T., Furuhata, T., Ohmura, T., Yamaguchi, K., Katsuramaki, T., Hata, F., Torigoe, T., Sato, N., Hirata, K
    • Organizer
      27th Japanese Research Society of Surgical Cancer Immunology
    • Place of Presentation
      Kita-kyushu
    • Year and Date
      2006-06-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] MHC class Iの発現異常は、癌悪性度の指標となりうるか2006

    • Author(s)
      岩山 祐司、鶴間 哲弘、古畑 智久、大村 東生、山口 浩司、桂巻 正、秦 史壮、鳥越 俊彦、佐藤 昇志
    • Organizer
      第61回日本消化器外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-07-13
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] Could the decrease of MHC class I expression level be a marker of malignant potential?2006

    • Author(s)
      Iwayama, Y., Tsuruma, T., Furuhata, T., Ohmura, T., Yamaguchi, K., Katsuramaki, T., Hata, F., Torigoe, T., Sato, N
    • Organizer
      61_st Annual Meeting of the Japanese Society of Gastroenterological Surgery
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-07-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] ペプチドワクチン療法 如何に抗腫瘍効果を誘導するか〜サバイビン2Bペプチドワクチン療法臨床試験から得られたもの2006

    • Author(s)
      岩山 祐司、鶴間 哲弘、桂巻 正、古畑 智久、山口 浩司、木村 康利、鳥越 俊彦、佐藤 昇志、平田 公一
    • Organizer
      第19回バイオセラピイ学会学術集会総会
    • Place of Presentation
      福岡
    • Year and Date
      2006-12-01
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • [Presentation] A case report that peptide vaccine therapy, surgical removal offered a long-term survival2006

    • Author(s)
      Tsuruma, T., Furuhata, T., Hata, F., Kawasaki, H., Sawada, T., Yamaguchi, K., Hirosaki, K., Jinbo, K., Hirata, K
    • Organizer
      31th Annual Congress of Japanese College of Surgeons
    • Place of Presentation
      Kanazawa
    • Year and Date
      2006-06-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591420
  • 1.  HIRATA Koichi (50136959)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 6 results
  • 2.  SATO Noriyuki (50158937)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 18 results
  • 3.  MIZUGUCHI Toru (30347174)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  TORIGOE Tosihiko (20301400)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 18 results
  • 5.  FURUHATA Tomohisa (80359992)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 22 results
  • 6.  KIMURA Yasutoshi (80311893)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 7.  TSURUMA Tetsuhuro (80381268)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 20 results
  • 8.  OHMURA Tosei (30295349)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 9.  URA Hideki (50264510)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  桂巻 正 (50253993)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 12 results
  • 11.  岡田 洋次郎 (60305224)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  向谷 充宏 (00253998)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  茶木 良
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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