KIKUCHI Hitoshi 菊池仁志

Researcher Number	60322765
Affiliation (based on the past Project Information) *help	2008: Kyushu University, 大学病院, 特任講師 2007 – 2008: Kyushu University, 大学病院, Lecturer 2006: 九州大学, 大学病院, 助手 2006: 九州大学, 病院・神経内科(平成18年7月31日辞退), 助手 2000 – 2001: 九州大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Neurology / Neurology Except Principal Investigator Neurology / Neurology
Keywords	Principal Investigator Persistent infection / Demyelination / L* / Multiple sclerosis / Theiler's murine encephalomyelitis virus / 持続感染 / 脱髄 / L^* / キメラ / 実験的アレルギー脳炎 … More / 多発性硬化症 / タイラーウイルス / 異常蛋白質 / ALS / プロテアーゼ / 小胞体ストレス / 筋萎縮性側索硬化症 / 神経病態生化学 … More Except Principal Investigator Th1 / アポトーシス / Direct current stimulation / Electrical stimulation / Animal model / Neck cooling / Cooling / Epilepsy / キンドリング / 脳冷却 / 直流刺激 / 電気刺激 / 動物モデル / 頚部冷却 / 冷却 / てんかん / allergic conjunctivitis / intracellular cytokine / autoimmune disease / Th2 balance / apoptosis / allergy / thymus / myasthenia gravis / アレルギー性結膜炎 / 細胞内サイトカイン / 自己免疫疾患 / Th2バランス / アレルギー / 胸腺 / 重症筋無力症 / 免疫学 / 顆粒球コロニー刺激因子(G-CSF) / 筋萎縮性側索硬化症 / 病理学 / 神経化学 / 脳神経疾患 / ELISPOT / 抗AQP4抗体 / 自己反応性T細胞 / IL-17 / 視神経脊髄型 / 多発性硬化症 Less

Clarify the abnormal protein causing ER stress in ALS and therapeutic approachPrincipal Investigator
- Principal Investigator
  
  KIKUCHI Hitoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Role of IL-17 producing T cells in opticospinal multiple sclerosis
- Principal Investigator
  
  KIRA Jun-ichi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
筋萎縮性側索硬化症に対するG-CSF療法の開発
- Principal Investigator
  
  吉良潤一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
Neck cooling against epileptic discharges-study in rat model
- Principal Investigator
  
  SHIGETO Hiroshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyushu University
STUDY OF ALLERGIC REACTION IN PATHOGENESIS OF MYASTHENIA GRAVIS
- Principal Investigator
  
  MURAI Hiroyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  KYUSHU UNIVERSITY
Research for the mechanisms of continuous infection and demyelination of Theiler's murine encephalomyelitis virusPrincipal Investigator
- Principal Investigator
  
  KIKUCHI Hitoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  KYUSHU UNIVERSITY

All 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese : nationwide survey results over 30 years2009
- Author(s)
  Osoegawa M, Kira J, Fukazawa K, Kikuchi S, Kohriyama T, Sobue G, Yamamura T, Itoyama Y, Saida T, Sakata K, Ochi H, Matsuoka T
- Journal Title
  
  Multiple Sclerosis(Equal contribution) 15
  
  Pages: 159-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390261
[Journal Article] Cortical kindling in a focal freeze lesion rat model2009
- Author(s)
  Takase K, Shigeto H, Suzuki SO, Kikuchi H, Ohyagi Y, Kira J.
- Journal Title
  
  J Clin Neurosci 16
  
  Pages: 94-98
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Cortical kindling in a focal freeze lesion rat model.2009
- Author(s)
  Takase K, Shigeto H, Suzuki so, Kikuchi H, Ohyagi Y, Kira J.
- Journal Title
  
  J Clin Neurosci 16
  
  Pages: 94-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Heterogeneity and continuum of multiple sclerosis phenotypes in Japanese according to the results of the fourth nationwide survey(Equal contribution)2009
- Author(s)
  Ishizu T, Kira J, Osoegawa M, Fukazawa T, Kikuchi S, Fujihara K, Matsui M, Kohriyama T, Sobue G, Yamamura T, Itoyama Y, Saida T, Sakata K
- Journal Title
  
  J Neurol Sci 280
  
  Pages: 22-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390261
[Journal Article] Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia.2008
- Author(s)
  Takase KI, Shigeto H. Suzuki SO, Kikuchi H, Ohyagi Y, Kira JI.
- Journal Title
  
  Epilepsia 49
  
  Pages: 997-1010
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590947
[Journal Article] Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia.2008
- Author(s)
  Takase K, Shigeto H, Suzuki so, Kikuchi H, Ohyagi Y, Kira J.
- Journal Title
  
  Epilepsia. 49
  
  Pages: 997-1010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia2008
- Author(s)
  Takase K, Shigeto H, Suzuki SO, Kikuchi H, Ohyagi Y, Kira J.
- Journal Title
  
  Epilepsia 49
  
  Pages: 997-1010
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Anterior periventricular linear lesions in optic-spinal multiplesclerosis : a combined neuroimaging and neuropathological study.2008
- Author(s)
  Matsushita T, Matsuoka T, Ishizu T, Kikuchi H, 他5名
- Journal Title
  
  Multiple Sclerosis 14
  
  Pages: 343-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia.2008
- Author(s)
  Takase KI, Shigeto H, Suzuki SO, Kikuchi H, Ohyagi Y, Kira JI.
- Journal Title
  
  Epilepsia 49
  
  Pages: 997-1010
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590947
[Journal Article] Anterior periventricular linear lesions in optic-spinal multiple sclerosis : a combined neuroimaging and neuropathological study2008
- Author(s)
  Matsushita T, Matsuoka T, Ishizu T, Kikuchi H, 他5名
- Journal Title
  
  Multiple Sclerosis 14
  
  Pages: 343-353
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia2008
- Author(s)
  Takase KI, Shigeto H, Suzuki SO, Kikuchi H, Ohyagi Y, Kira JI
- Journal Title
  
  Epilepsia (印刷中)(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Anterior periventricular linear lesions in optic-spinal multiple sclerosis : a combined neuroimaging and neuropathological study2008
- Author(s)
  Matsushita T, Matsuoka T, Ishizu T, Kikuchi H, Osoegawa M, Kawano Y, Mihara F, Ohyagi Y, Kira J
- Journal Title
  
  Multiple Sclerosis 14
  
  Pages: 343-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390261
[Journal Article] Anterior periventricular linear lesions in optic-spinal multiple sclerosis:a combined neuroimaging and neuropathological study2008
- Author(s)
  Matsushita T, Matsuoka T, Ishizu T, Kikuchi H, 他5名
- Journal Title
  
  Multiple Sclerosis (印刷中)(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia2008
- Author(s)
  Takase KI, Shigeto H, Suzuki SO, Kikuchi H, Ohyagi Y, Kira J
- Journal Title
  
  Epilepsia (Published online)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590947
[Journal Article] Intraneuronal amyloid beta42 enhanced by heating but counteracted by formicacid2007
- Author(s)
  Ohyagi Y, Tsuruta Y, Motomura K, Miyoshi K, Kikuchi H, 他3名
- Journal Title
  
  J Neurosci Methods 159
  
  Pages: 134-138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in multiple sclerosis in Japanese2007
- Author(s)
  Matsuoka T, Matsushita T, Kawano Y, Osoegawa M, Ochi H, Ishizu T, Minohara. M, Kikuchi H, 他3名
- Journal Title
  
  Brain 130
  
  Pages: 1206-1223
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in multiple-sclerosis in Japanese2007
- Author(s)
  Matsuoka T, Matsushita T, Kawano Y, Osoegawa M, Ochi H, Ishizu T, Minohara M, Kikuchi H, 他3名
- Journal Title
  
  Brain 130
  
  Pages: 1206-1223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Slorvly progressive distal muscular atrophy of the bilateral upper limbs(O'Sullivan-McLeod syndrome) partially alleviated by intravenous immunoglobulin therapy2007
- Author(s)
  Kawano Y, Nagara Y, Murai H, Kikuchi H, Ohyagi Y, Kira J.
- Journal Title
  
  Intern Med 46
  
  Pages: 515-518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Intraneuronal amyloid beta42 enhanced by heating but counteracted by formic acid2007
- Author(s)
  Ohyagi Y, Tsuruta Y, Motomura K, Miyoshi K, Kikuchi H, 他3名
- Journal Title
  
  J Neurosci Methods
  
  Pages: 134-138
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Increased IL-13-producing T cells in ALS:positive correlations with disease severity and progression rate2007
- Author(s)
  Shi N, Kawano Y, Tateishi T, Kikuchi H, 他3名
- Journal Title
  
  J Neuroimmunol 182
  
  Pages: 232-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in multiple sclerosis in Japanese2007
- Author(s)
  Matsuoka T, Matsushita T, Kawano Y, Osoegawa M, Ochi H, Ishizu T, Minohara M, Kikuchi H, Mihara F, Ohyagi Y, Kira J
- Journal Title
  
  Brain 130
  
  Pages: 1206-1223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390261
[Journal Article] Slowly progressive distal muscular atrophy of the bilateral upper limbs (O'Sullivan-McLeod syndrome) partially alleviated by intravenous immunoglobulin therapy2007
- Author(s)
  Kawano Y, Nagara Y, Murai H, Kikuchi H, Ohyagi Y, Kira J.
- Journal Title
  
  Intern Med 46
  
  Pages: 515-518
- NAID
  130000078746
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Increased IL-13-producing T cells in ALS : positive correlations with disease severity and progression rate2007
- Author(s)
  Shi N, Kawano Y, Tateishi T, Kikuchi H, 他3名
- Journal Title
  
  J Neuroimmunol 182
  
  Pages: 232-235
- Data Source
  KAKENHI-PROJECT-19590997
[Journal Article] Motor neuron disorder simulating ALS induced by chronic inhalation of pyrethroid insecticides.2006
- Author(s)
  Doi H, Kikuchi H, Murai H, Kawano Y, Shigeto H, Ohyagi Y, Kira J.
- Journal Title
  
  Neurology 67
  
  Pages: 1894-1985
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590947
[Journal Article] The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental allergic encephalomyelitis2006
- Author(s)
  Sun X, Minohara M, Kikuchi S, Ishizu T, Tanaka M, Piao H, Osoegawa M, Ohyagi Y, Shimokawa H, Kira J
- Journal Title
  
  J Neuroimmunol 180
  
  Pages: 126-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390261
[Presentation] 変異SODIトランスジェニツクマウスにおけるミクロクリア機能障害2009
- Author(s)
  山崎亮, 福永真実, 立石貴久, 田中正人, 菊池仁志, 大八木保政, 吉良潤一.
- Organizer
  第21回日本神経免疫学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19590997
[Presentation] 変異SOD1トランスジェニックマウスにおけるミクログリア機能障害2009
- Author(s)
  山崎亮, 福永真実, 立石貴久, 田中正人, 菊池仁志, 大八木保政, 吉良潤一
- Organizer
  第21回日本神経免疫学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19590997
[Presentation] mSODl G93Aマウスにおける、VEGFとHIF-lαの発現の解析、2008
- Author(s)
  立石貴久, 田中正人, 山崎亮, 菊池仁志, 吉良潤一
- Organizer
  日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19590997
[Presentation] Prenatal Freeze Lesioning Produces Epileptogenic Focal Cortical Dysplasia.2008
- Author(s)
  Kei-ichiro Takase, Hiroshi Shigeto, Satoshi O. Suzuki, Hitoshi Kikuchi, Yasumasa Ohyagi, Jun-ichi Kira.
- Organizer
  American academy of Neurology.
- Place of Presentation
  Boston
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590947
[Presentation] Prenatal Freeze Lesioning Produces Epileptogenic Focal Cortical Dysplasia.2008
- Author(s)
  Kei-ichiro Takase Hiroshi Shigeto, Satoshi O. Suzuki, Hitoshi Kikuchi, Yasumasa Ohyagi, Jun-ichi Kira.
- Organizer
  American academy of Neurology
- Place of Presentation
  Boston
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590947
[Presentation] ALS患者におけるNIPPV下での経皮内視鏡的胃ろう造設術の検討2008
- Author(s)
  菊池仁志, 田代博文, 大久保正一, 久米徹
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19590997
[Presentation] 変異SOD1-Tgマウスにおける神経細胞脆弱性とミクログリア機能障害2008
- Author(s)
  山崎亮, 田中正人, 立石貴久, 菊池仁志, 吉良潤一
- Organizer
  日本神経学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590997
[Presentation] ALS患者におけるNIPPV下での経皮内視鏡的胃ろう造設術の検討2008
- Author(s)
  菊池仁志, 田代博文, 大久保正一, 久米徹
- Organizer
  日本神経学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590997
[Presentation] 変異SODl-Tgマウスにおける神経細胞脆弱性とミクロクリア機能障害、2008
- Author(s)
  山崎亮, 田中正人, 立石貴久, 菊池仁志, 吉良潤一
- Organizer
  日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19590997
[Presentation] mSOD1 G93Aマウスにおける, VEGFとHIF-1αの発現の解析2008
- Author(s)
  立石貴久, 田中正人, 山崎亮, 菊池仁志, 吉良潤一
- Organizer
  日本神経学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590997

1. KIRA Jun-ichi (40183305)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. KAWAMURA Nobutoshi (00432930)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. TATEISHI Takahisa (50423546)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. MURAI Hiroyuki (80325464)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MINOHARA Motozumi (70398113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. OCHI Hirofumi (20325442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SHIGETO Hiroshi (50335965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. TANIWAKI Takayuki (80284496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 河野祐治 (20333479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

KIKUCHI Hitoshi 菊池 仁志

Research Projects

Research Products

Co-Researchers

Clarify the abnormal protein causing ER stress in ALS and therapeutic approachPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of IL-17 producing T cells in opticospinal multiple sclerosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

筋萎縮性側索硬化症に対するG-CSF療法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neck cooling against epileptic discharges-study in rat model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

STUDY OF ALLERGIC REACTION IN PATHOGENESIS OF MYASTHENIA GRAVIS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for the mechanisms of continuous infection and demyelination of Theiler's murine encephalomyelitis virusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese : nationwide survey results over 30 years2009

Author(s)

Journal Title

Data Source

[Journal Article] Cortical kindling in a focal freeze lesion rat model2009

Author(s)

Journal Title

Data Source

[Journal Article] Cortical kindling in a focal freeze lesion rat model.2009

Author(s)

Journal Title

Data Source

[Journal Article] Heterogeneity and continuum of multiple sclerosis phenotypes in Japanese according to the results of the fourth nationwide survey(Equal contribution)2009

Author(s)

Journal Title

Data Source

[Journal Article] Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia.2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia.2008

Author(s)

Journal Title

Data Source

[Journal Article] Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia2008

Author(s)

Journal Title

Data Source

[Journal Article] Anterior periventricular linear lesions in optic-spinal multiplesclerosis : a combined neuroimaging and neuropathological study.2008

Author(s)

Journal Title

Data Source

[Journal Article] Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia.2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Anterior periventricular linear lesions in optic-spinal multiple sclerosis : a combined neuroimaging and neuropathological study2008

Author(s)

KIKUCHI Hitoshi 菊池仁志