MASATOSHI Takagi 高木昌俊

… Alternative Names

高木昌俊タカギマサトシ

TAKAGI Masatoshi 高木昌俊

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Researcher Number	60324779
Other IDs
External Links
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 専任研究員
Affiliation (based on the past Project Information) *help	2018 – 2023: 国立研究開発法人理化学研究所, 開拓研究本部, 専任研究員 2015 – 2017: 国立研究開発法人理化学研究所, 今本細胞核機能研究室, 専任研究員 2012 – 2014: 独立行政法人理化学研究所, 今本細胞核機能研究室, 専任研究員 2007 – 2008: RIKEN, 今本細胞核機能研究室, Senior Staff Scientist 2006: 独立行政法人理化学研究所, 今本細胞核機能研究室, 先任研究員 2004 – 2005: 独立行政法人理化学研究所, 今本細胞核機能研究室, 研究員
Review Section/Research Field	Principal Investigator Cell biology / Basic Section 44010:Cell biology-related / Molecular biology Except Principal Investigator Biological Sciences / Cell biology
Keywords	Principal Investigator 分裂期染色体 / Ki67抗原 / トポイソメラーゼ / Ki-67抗原 / AID / Ki-67 / KiTop複合体 / オーキシン誘導性デグロン / 液液相分離 / コンデンシン … More / 微小核 / 染色体間グルー / 染色体安定性 / 染色体 / 細胞分裂期 / 脱リン酸化酵素 / 分裂期 … More Except Principal Investigator 核膜孔複合体 / 核膜 / 細胞周期 / B-type lamin / Emerin / A-type lamin / 核内膜 / Mitotic chromosome / Importin / Nucleocvtoplasmic transport / Live imaging / Cell Cycle / Small GTPase Ran / Nuclear Envelope / Nuclear Pore Complex / Lap2α / LBR(Lamin B receptor) / emerin / インシュレーター / CDKインヒビター / 細胞核 / マルチ遺伝子発現システム / Photobleach / 染色体 / 低分子量GTPase Ran / インポーチン / 核-細胞質間輸送 / 核内膜タンパク質 / 生細胞イメージング / 核-細胞質間輸送因子 / 分裂期染色体 / 細胞分裂期 / 核膜前駆体小胞 / LBR / 細胞分裂 / リアルタイムイ蛍光メージング / セミインタクト細胞 / 紡錘体 / 膜貫通型核膜因子 / 核ラミナ / siRNA / pom121 / 膜貫通型核膜孔複合体構成因子 / photo-bleaching / アフリカツメガエル卵 / 初期化 / クロマチン / 核のリモデリング / DNA合成 / Xenopus卵 / 再構築系 Less

Ki-67抗原を含む新たなタンパク質複合体 (KiTop複合体）の機能解析Principal Investigator
- Principal Investigator
  
  高木昌俊
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Institute of Physical and Chemical Research
Molecular mechanisms on which Ki-67 contributes to the organization of mitotic chromosomesPrincipal Investigator
- Principal Investigator
  
  Takagi Masatoshi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Institute of Physical and Chemical Research
Physiological significance of the inter-chromosomal glue that loosely clusters mitotic chromosomesPrincipal Investigator
- Principal Investigator
  
  Takagi Masatoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Institute of Physical and Chemical Research
Analysis of the possible contribution of perichromosomal field to the chromosomal stabilityPrincipal Investigator
- Principal Investigator
  
  MASATOSHI Takagi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Institute of Physical and Chemical Research
核膜サブドメインを形成する分子基盤と形成機構の解析
- Principal Investigator
  
  今本尚子
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Role of Nuclear Pore Complexes on Nuclear Organization
- Principal Investigator
  
  IMAMAOTO Naoko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  The Institute of Physical and Chemical Research
核膜孔複合体のダイナミクス:メカニズムと制御機構の解析
- Principal Investigator
  
  今本尚子
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
核のリモデリングに伴う核膜孔複合体の機能・構造・動態変化の解析
- Principal Investigator
  
  IMAMAOTO Naoko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  The Institute of Physical and Chemical Research

[Book] 核と細胞質のあいだの輸送を担う因子の新たな機能- Kid をモデル分子としてみえてきたもの2008
- Author(s)
  高木昌俊, 他
- Total Pages
  15
- Publisher
  蛋白質核酸酵素
- Data Source
  KAKENHI-PROJECT-19038027
[Book] Kidをモデル分子に用いて見えてきた新たな核-細胞質間輸送因子の機能。蛋白質核酸酵素。2008
- Author(s)
  高木昌俊、田原清志、今本尚子
- Publisher
  共立出版(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370083
[Journal Article] StayGold variants for molecular fusion and membrane-targeting applications2023
- Author(s)
  Ando Ryoko、Shimozono Satoshi、Ago Hideo、Takagi Masatoshi、Sugiyama Mayu、Kurokawa Hiroshi、Hirano Masahiko、Niino Yusuke、Ueno Go、Ishidate Fumiyoshi、Fujiwara Takahiro、Okada Yasushi、Yamamoto Masaki、Miyawaki Atsushi
- Journal Title
  
  Nature Methods
  
  Volume: 21 Issue: 4 Pages: 648-656
- DOI
  10.1038/s41592-023-02085-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06649, KAKENHI-PROJECT-21H05041, KAKENHI-PROJECT-23K24060
[Journal Article] Cell cycle-specific phase separation regulated by protein charge blockiness2022
- Author(s)
  Yamazaki H、Takagi M、Kosako H、Hirano T、Yoshimura SH.
- Journal Title
  
  Nature Cell Biology
  
  Volume: - Issue: 5 Pages: 625-632
- DOI
  10.1038/s41556-022-00903-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15039, KAKENHI-PROJECT-20K06628, KAKENHI-PROJECT-20K06649, KAKENHI-PLANNED-20H05938, KAKENHI-PROJECT-18H05276
[Journal Article] Stochastic chromatin packing of 3D mitotic chromosomes revealed by coherent X-rays2021
- Author(s)
  Sung Daeho、Lim Chan、Takagi Masatoshi、Jung Chulho、Lee Heemin、Cho Do Hyung、Shin Jae-Yong、Ahn Kangwoo、Hwang Junha、Nam Daewoong、Kohmura Yoshiki、Ishikawa Tetsuya、Noh Do Young、Imamoto Naoko、Jeon Jae-Hyung、Song Changyong
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 46
- DOI
  10.1073/pnas.2109921118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02442, KAKENHI-PROJECT-20K06649, KAKENHI-PROJECT-21H02482
[Journal Article] VPS72/YL1-Mediated H2A.Z Deposition Is Required for Nuclear Reassembly after Mitosis2020
- Author(s)
  Moreno-Andres Daniel、Yokoyama Hideki、Scheufen Anja、Holzer Guillaume、Lue Hongqi、Schellhaus Anna Katharina、Weberruss Marion、Takagi Masatoshi、Antonin Wolfram
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 7 Pages: 1702-1702
- DOI
  10.3390/cells9071702
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06649, KAKENHI-PROJECT-17K07399, KAKENHI-PROJECT-16K21749
[Journal Article] Generation of an antibody recognizing a set of acetylated proteins, including subunits of BAF complexes2019
- Author(s)
  Takagi Masatoshi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 22 Pages: 100720-100720
- DOI
  10.1016/j.bbrep.2019.100720
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07399
[Journal Article] Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms2018
- Author(s)
  Takagi Masatoshi、Ono Takao、Natsume Toyoaki、Sakamoto Chiyomi、Nakao Mitsuyoshi、Saitoh Noriko、Kanemaki Masato T.、Hirano Tatsuya、Imamoto Naoko
- Journal Title
  
  Journal of Cell Science
  
  Volume: 131 Pages: 212092-212092
- DOI
  10.1242/jcs.212092
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07399, KAKENHI-PROJECT-17K15068, KAKENHI-INTERNATIONAL-15K21744, KAKENHI-PROJECT-26251003, KAKENHI-PLANNED-15H05929, KAKENHI-PLANNED-25116009, KAKENHI-PROJECT-15H04707, KAKENHI-PROJECT-16K15095, KAKENHI-PROJECT-18K19310, KAKENHI-PUBLICLY-18H04719, KAKENHI-PROJECT-16H04744, KAKENHI-PROJECT-18H02170, KAKENHI-PROJECT-16K07455
[Journal Article] ELYS regulates the localization of LBR by modulating its phosphorylation state.2017
- Author(s)
  Mimura Y, Takagi M, Clever M, Imamoto N.
- Journal Title
  
  J Cell Sci.
  
  Volume: 129(22) Issue: 22 Pages: 4200-4212
- DOI
  10.1242/jcs.190678
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26650070
[Journal Article] Prichromosomal protein Ki67 supports mitotic chromosome architecture.2016
- Author(s)
  Takagi M, Natsume T, Kanemaki MT, Imamoto N.
- Journal Title
  
  Genes to Cells
  
  Volume: 21(10) Issue: 10 Pages: 1113-1124
- DOI
  10.1111/gtc.12420
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26650070, KAKENHI-PROJECT-15K18482, KAKENHI-PROJECT-16K15095
[Journal Article] Ki-67 is a PP1-interacting protein that organizes the mitotic chromosome periphery2014
- Author(s)
  Booth, D., Takagi, M., Sanchez-Pulido, L., Petfalski, E., Vargiu, G., Samejima, K., Imamoto, N., Ponting, C., Tollervey, D., Earnshaw, W., and Vagnerelli, P.
- Journal Title
  
  eLife
  
  Volume: 27;3
- DOI
  10.7554/elife.01641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657124, KAKENHI-PROJECT-26650070
[Journal Article] Ki67 antigen contributes to the timely accumulation of protein phosphatase 1γ on anaphase chromosomes.2014
- Author(s)
  Takagi M, Nishiyama Y, Taguchi A, Imamoto N.
- Journal Title
  
  J Biol Chem.
  
  Volume: 15;289(33) Issue: 33 Pages: 22877-87
- DOI
  10.1074/jbc.m114.556647
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26650070
[Journal Article] Analytic 3D imaging of mammalian nucleus at nanoscale using coherent x-rays and optical fluorescence microscopy.2014
- Author(s)
  Song C, Takagi M, Park J, Xu R, Gallagher-Jones M, Imamoto N, Ishikawa T.
- Journal Title
  
  Biophys J.
  
  Volume: 107(5) Issue: 5 Pages: 1074-81
- DOI
  10.1016/j.bpj.2014.07.028
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26650070
[Journal Article] Control of Nuclear Size by NPC Proteins2014
- Author(s)
  Masatoshi Takagi, Naoko Imamoto
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: 773 Pages: 571-591
- DOI
  10.1007/978-1-4899-8032-8_26
- ISBN
  9781489980311, 9781489980328
- Data Source
  KAKENHI-PROJECT-24657124
[Journal Article] Control of Nuclear Size by NPC Proteins2014
- Author(s)
  Takagi, M., and Imamoto, N.
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: Vol. 773 Pages: 571-591
- Data Source
  KAKENHI-PROJECT-24657124
[Journal Article] Cloning of Xenopus orthologs of Ctf7/Ecol acetyltransferase and initial characterization of XE_<co>2.2008
- Author(s)
  Takagi, M., 他
- Journal Title
  
  FEBS J. 275
  
  Pages: 6109-6122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19038027
[Journal Article] Expanding role of the nucleocytpoplasmic transport system during mitosis revealed by analyzing the mechanism to Kid into mitotic chromosomes.
- Author(s)
  Takagi, et. al.
- Journal Title
  
  PNE review article (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370083
[Presentation] Molecular mechanisms on which Ki-67 supports the architecture of mitotic chromosomes from their periphery2024
- Author(s)
  Masatoshi Takagi
- Organizer
  RIKEN International Symposium on Nuclear Structure and Function
- Data Source
  KAKENHI-PROJECT-20K06649
[Presentation] Ki-67が分裂期染色体の構築をその周囲から支持する分子メカニズム2023
- Author(s)
  高木昌俊
- Organizer
  第４６回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20K06649
[Presentation] コンデンシン複合体やKi-67抗原に依存しない染色体コンパクション2021
- Author(s)
  高木昌俊
- Organizer
  第39回染色体ワークショップ・第19回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-20K06649
[Presentation] Ki-67抗原が分裂期染色体構造を支持する分子機構2019
- Author(s)
  高木昌俊
- Organizer
  第３６回染色体ワークショップ、第１７回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-17K07399
[Presentation] How Ki-67 functions to support the architecture of mitotic chromosomes2018
- Author(s)
  Masatoshi Takagi
- Organizer
  EMBO | EMBL Symposium: Principles of Chromosome Structure and Function
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07399
[Presentation] Ki-67 and condensins cooperates to support the architecture of mitotic chromosomes through distinct mechanisms2017
- Author(s)
  Takagi M, Ono T, Natsume T, Sakamoto C, Nakao M, Saitoh N, Kanemaki MT, Hirano T, Imamoto N
- Organizer
  The 2nd meeting on SMC proteins
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07399
[Presentation] The prichromosomal protein Ki67 supports mitotic chromosome architecture.2016
- Author(s)
  Takagi M, Natsume T, Kanemaki MT, Imamoto N.
- Organizer
  第３９回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26650070
[Presentation] Exploration of the Histone Code Read by the LR Domain of Ki672015
- Author(s)
  高木昌俊、今本尚子
- Organizer
  第６７回日本細胞生物学会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-07-01
- Data Source
  KAKENHI-PROJECT-26650070
[Presentation] Ki67抗原により染色体表層領域へリクルートされるPP1γの役割2013
- Author(s)
  高木昌俊
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-24657124
[Presentation] Ki67抗原により染色体表層領域へリクルートされるPP1γの役割2013
- Author(s)
  高木昌俊、田口温子、西山祐子、今本尚子
- Organizer
  第６３回日本分子生物学会
- Place of Presentation
  兵庫　神戸ポートアイランド
- Invited
- Data Source
  KAKENHI-PROJECT-24657124
[Presentation] Ki67抗原により染色体表層領域にリクルートされるPP1gの役割2012
- Author(s)
  高木　昌俊
- Organizer
  第３０回染色体ワークショップ・第１１回核ダイナミクス研究会（合同開催）
- Place of Presentation
  淡路夢舞台国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-24657124
[Presentation] Ki67抗原により染色体表層領域へリクルートされるPP1γの役割2012
- Author(s)
  高木昌俊
- Organizer
  第30回染色体ワークショップ
- Place of Presentation
  淡路夢舞台国際会議場
- Year and Date
  2012-12-20
- Data Source
  KAKENHI-PROJECT-24657124
[Presentation] Ki67/chmadrin複合体がRNA代謝制御を介して分裂期染色体動態を制御する可能性2008
- Author(s)
  高木昌俊, 他
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19038027
[Presentation] Ki67抗原が分裂期表層領域にPCFを樹立する分子機構
- Author(s)
  高木昌俊、今本尚子
- Organizer
  第３２回染色体ワークショップ、第１３回核ダイナミクス研究会（合同）
- Place of Presentation
  広島
- Year and Date
  2014-12-15 – 2014-12-17
- Data Source
  KAKENHI-PROJECT-26650070

1. IMAMAOTO Naoko (20202145)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. KOSE Shingo (90333278)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MAESHIMA Kazuhiro (00392118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 武内桂吾 (10392101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大木本圭 (20415102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 舩越智子 (90318460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山崎啓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MASATOSHI Takagi 高木 昌俊

高木 昌俊 タカギ マサトシ

TAKAGI Masatoshi 高木 昌俊

Research Projects

Research Products

Co-Researchers

Ki-67抗原を含む新たなタンパク質複合体 (KiTop複合体）の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms on which Ki-67 contributes to the organization of mitotic chromosomesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Physiological significance of the inter-chromosomal glue that loosely clusters mitotic chromosomesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the possible contribution of perichromosomal field to the chromosomal stabilityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

核膜サブドメインを形成する分子基盤と形成機構の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of Nuclear Pore Complexes on Nuclear Organization

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

核膜孔複合体のダイナミクス:メカニズムと制御機構の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

核のリモデリングに伴う核膜孔複合体の機能・構造・動態変化の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 核と細胞質のあいだの輸送を担う因子の新たな機能- Kid をモデル分子としてみえてきたもの2008

Author(s)

Total Pages

Publisher

Data Source

[Book] Kidをモデル分子に用いて見えてきた新たな核-細胞質間輸送因子の機能。蛋白質核酸酵素。2008

Author(s)

Publisher

Description

Data Source

[Journal Article] StayGold variants for molecular fusion and membrane-targeting applications2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell cycle-specific phase separation regulated by protein charge blockiness2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stochastic chromatin packing of 3D mitotic chromosomes revealed by coherent X-rays2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] VPS72/YL1-Mediated H2A.Z Deposition Is Required for Nuclear Reassembly after Mitosis2020

MASATOSHI Takagi 高木昌俊

高木昌俊タカギマサトシ

TAKAGI Masatoshi 高木昌俊