Tsuda Hiromasa 津田啓方

… Alternative Names

TSUDA Hiromasa 津田啓方

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Researcher Number	60325470
Other IDs	https://orcid.org/0000-0002-2047-2262
Affiliation (Current)	2025: 日本大学, 歯学部, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 日本大学, 歯学部, 准教授 2009 – 2013: Nihon University, 歯学部, 助教 2007 – 2008: Nihon University, 歯学部, 助手
Review Section/Research Field	Principal Investigator Social dentistry / Basic Section 57040:Regenerative dentistry and dental engineering-related / Basic Section 57020:Oral pathobiological science-related / Pathobiological dentistry/Dental radiology Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Basic Section 50010:Tumor biology-related / Morphological basic dentistry
Keywords	Principal Investigator 歯周炎 / 細胞死 / 予防法 / オートファジー / 歯肉上皮 / 短鎖脂肪酸 / 自己免疫疾患 / DAMPs / 活性酸素種 / 三次元培養系 … More / 破骨細胞 / 軟組織細胞 / アルカリフォスファターゼ / ポリリン酸 / 硬組織 / 三次元培養体 / 炎症 / 歯肉 / 歯肉培養系モデル / 歯肉オルガノイド / 白血球 / 血管 / HDAC阻害 / 歯肉上皮細胞 / 歯周組織 / オルガノイド / マクロファージ / 歯周疾患 / 三次元培養 / 関節リウマチ / 骨破壊 / 骨吸収 / エピジェネティクス / 活性化剤・抑制剤 / 代謝調節因子 / 破骨細胞分化 / 食品由来成分 / 歯槽骨破壊 / 分化 / エピジェネティック / 骨破壞 / ヒストンメチル化 / ヒストンアセチル化 / プロピオン酸 / 骨芽細胞 / 骨 / 酪酸 / アポトーシス … More Except Principal Investigator 口腔癌 / 遺伝子 / バイオマーカー / 遺伝子ネットワーク / マイクロRNA / スーパーエンハンサー / 遺伝子ネットワーク解析 / パスウェイ解析 / バイオインフォマティクス / がん関連遺伝子 / ネットワーク解析 / マイクロアレイ解析 / エクソソーム / microRNA / 口腔がん / 悪性化 / がん / がん悪性化 / 口腔上皮がん / Galectin4 / 細胞接着 / 細胞移動能 / SLPI / 膣内細菌 / 腸内細菌叢 / HIV / エピジェネティク制御 / n-酪酸 / 短鎖脂肪酸 / 歯周病 / 微生物間相互作用 / ウイルス / HDAC / 酸化ストレス / EBV / エピジェネティクス / 酪酸 Less

Development of a three-dimensional hard tissue culture system using inorganic polyphosphate and soft-tissue cells.Principal Investigator
- Principal Investigator
  
  津田啓方
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Nihon University
スーパーエンハンサーを標的とする遺伝子発現制御による口腔癌発癌機構の解明
- Principal Investigator
  
  篠塚啓二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Nihon University
Development of human gingival organoid systems and investigation for the induction mechanisms of gingival inflammation and autoimmune diseases.Principal Investigator
- Principal Investigator
  
  TSUDA Hiromasa
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Nihon University
Development of highly sensitive diagnostic and therapeutic methods using exosomes as a new biomarker for oral cancer
- Principal Investigator
  
  SHINOZUKA Keiji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Nihon University
Study of the mechanism underlying secretory leukocyte protease inhibitor (SLPI)-induced malignancy of cancer
- Principal Investigator
  
  Mikami Yoshikazu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Niigata University
Development of prevention methods against periodontal-disease derived rheumatoid-arthritis using 3-demensional culture model of human gingival tissue.Principal Investigator
- Principal Investigator
  
  TSUDA Hiromasa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Nihon University
Effects of butyric acid producing bacteria on epigenetic gene regulation and systemic diseases
- Principal Investigator
  
  OCHIAI Kuniyasu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Nihon University
Development of periodontitis-preventive methods using epigenetically controling food ingredientPrincipal Investigator
- Principal Investigator
  
  TSUDA Hiromasa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Nihon University
Development of methods to prevent alveolar bone absorption during periodontitis using epigenetic regulationPrincipal Investigator
- Principal Investigator
  
  TSUDA Hiromasa
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Social dentistry
- Research Institution
  Nihon University
Development of preventive methods from destruction of alveolar bone during periodontal disease using short chain fatty acidPrincipal Investigator
- Principal Investigator
  
  TSUDA Hiromasa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Social dentistry
- Research Institution
  Nihon University

All 2024 2023 2022 2021 2019 2018 2017 2014 2013 2012 2011 2009 Other

All Journal Article Presentation Book

[Book] Autophagy: Principles, Regulation and Roles in Disease2012
- Author(s)
  Tsuda　H and Mikami Y
- Total Pages
  352
- Publisher
  Nova Science Publishers, Hauppauge NY USA
- Data Source
  KAKENHI-PROJECT-23593104
[Journal Article] Possible roles of short-chain fatty acids produced by oral bacteria in the development of alveolar osteitis2024
- Author(s)
  Asayama Takayuki、Takada Ayaka、Mikami Yoshikazu、Yamaguchi Hirofumi、Tamura Muneaki、Matsumoto Kunihito、Miyake Kiwa、Yonehara Yoshiyuki、Tsuda Hiromasa
- Journal Title
  
  Journal of Oral Science
  
  Volume: 66 Issue: 2 Pages: 102-106
- DOI
  10.2334/josnusd.23-0410
- ISSN
  1343-4934, 1880-4926
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09913, KAKENHI-PROJECT-21K10219
[Journal Article] Reactive oxygen species generation required for autophagy induction during butyrate- or propionate-induced release of damage-associated molecular patterns from dying gingival epithelial Ca9-22 cells2024
- Author(s)
  Miyake Kiwa、Mikami Yoshikazu、Asayama Takayuki、Toriumi Taku、Shinozuka Keiji、Tonogi Morio、Yonehara Yoshiyuki、Tsuda Hiromasa
- Journal Title
  
  Journal of Oral Science
  
  Volume: 66 Issue: 2 Pages: 125-129
- DOI
  10.2334/josnusd.23-0421
- ISSN
  1343-4934, 1880-4926
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09913
[Journal Article] Butyrate-treatment induces gingival epithelial cell death in a three-dimensional gingival-connective tissue hybrid co-culture system2023
- Author(s)
  Kurosawa Yusuke、Yamaguchi Hirofumi、Uemichi Kazuki、Shinozuka Keiji、Kirihara Yuki、Tsuda Hiromasa
- Journal Title
  
  Journal of Dental Sciences
  
  Volume: 18 Issue: 2 Pages: 893-897
- DOI
  10.1016/j.jds.2022.08.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09913
[Journal Article] Histone-deacetylase-inhibitory effects of periodontopathic-bacterial metabolites induce human gingival epithelial Ca9-22 cell death2022
- Author(s)
  Uemichi Kazuki、Mikami Yoshikazu、Watanabe Takayasu、Shinozuka Keiji、Tonogi Morio、Tsuda Hiromasa
- Journal Title
  
  Odontology
  
  Volume: - Issue: 3 Pages: 658-667
- DOI
  10.1007/s10266-022-00775-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09913
[Journal Article] Reactive oxygen species-dependent release of damage-associated molecular patterns from human gingival epithelial Ca9-22 cells during butyrate or propionate exposure2021
- Author(s)
  Fujiwara Yui、Murofushi Takahisa、Koshi Ryosuke、Mikami Yoshikazu、Tsuda Hiromasa
- Journal Title
  
  Journal of Oral Science
  
  Volume: 63 Issue: 2 Pages: 195-197
- DOI
  10.2334/josnusd.20-0411
- NAID
  130008009597
- ISSN
  1343-4934, 1880-4926
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09913
[Journal Article] Bioinformatics analysis of dysregulated exosomal microRNAs derived from oral squamous cell carcinoma cells2021
- Author(s)
  Masaoka Tadashi、Shinozuka Keiji、Ohara Kenshin、Tsuda Hiromasa、Imai Kenichi、Tonogi Morio
- Journal Title
  
  Journal of Oral Science
  
  Volume: 63 Issue: 2 Pages: 174-178
- DOI
  10.2334/josnusd.20-0662
- NAID
  130008009559
- ISSN
  1343-4934, 1880-4926
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09913, KAKENHI-PROJECT-20K10126
[Journal Article] Presynaptic NK1 Receptor Activation by Substance P Suppresses EPSCs via Nitric Oxide Synthesis in the Rat Insular Cortex2021
- Author(s)
  Matsumura Sachie、Yamamoto Kiyofumi、Nakaya Yuka、O'Hashi Kazunori、Kaneko Keisuke、Takei Hiroki、Tsuda Hiromasa、Shirakawa Tetsuo、Kobayashi Masayuki
- Journal Title
  
  Neuroscience
  
  Volume: 455 Pages: 151-164
- DOI
  10.1016/j.neuroscience.2020.12.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09913, KAKENHI-PROJECT-20K10236, KAKENHI-PROJECT-19H03821
[Journal Article] Dual effect of polyphosphate on mineralization of rat osteoblast ROS17/2.8 cells in a dose-dependent manner2018
- Author(s)
  Mikami Y, Omagari D, Mizutani Y, Hayatsu M, Ushiki T, Tsuda H
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 138 Issue: 3 Pages: 209-213
- DOI
  10.1016/j.jphs.2018.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07226
[Journal Article] BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells.2013
- Author(s)
  Tsuda H, Zhao N, Imai K, Ochiai K, Yang P, Suzuki N.
- Journal Title
  
  Bosn J Basic Med Sci.
  
  Volume: 13 Pages: 271-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593104
[Journal Article] BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells2013
- Author(s)
  Tsuda H, Zhao N, Imai K, Ochiai K, Yang P, Suzuki N
- Journal Title
  
  Bosn J Basic Med Sci
  
  Volume: 13 Pages: 271-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592714
[Journal Article] BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells2013
- Author(s)
  Tsuda H,Zhao N,Imai K,Ochiai K,Yang P,Suzuki N
- Journal Title
  
  Bosn J Basic Med Sci
  
  Volume: vol.13 Pages: 271-275
- URL
  http://www.bjbms.org/archives/2013-4/11-Tsuda.pdf#search
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592714
[Journal Article] Programmed cell death and its possible relationship with periodontal disease.2012
- Author(s)
  Tsuda H, Ning Z
- Journal Title
  
  Journal of oral science
  
  Volume: 54 Pages: 137-149
- NAID
  130002070027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593104
[Presentation] 口腔内細菌の代謝産物が抜歯窩治癒不全時の抜歯窩骨壁への骨添加および炎症の遅延を引き起こす可能性2023
- Author(s)
  朝山雄之、津田啓方、鈴木直人
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K09913
[Presentation] 口腔内細菌代謝産物が破骨細胞分化に及ぼす影響2022
- Author(s)
  朝山雄之，津田啓方，生木俊輔，鈴木直人，米原啓之
- Organizer
  第74回日本大学歯学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-20K09913
[Presentation] 歯肉上皮細胞の短鎖脂肪酸誘導細胞死には活性酸素によるオートファジー誘導が必要である2022
- Author(s)
  三宅希和，津田啓方，篠塚啓二，鈴木直人，外木守雄
- Organizer
  第74回日本大学歯学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-20K09913
[Presentation] 口腔内細菌の代謝産物である短鎖脂肪酸がRANKL誘導破骨細胞形成に及ぼす影響2022
- Author(s)
  朝山雄之，津田啓方
- Organizer
  第64回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-20K09913
[Presentation] 歯周組織で誘導される細胞死が歯周疾患および全身疾患に及ぼしうる影響2021
- Author(s)
  津田啓方
- Organizer
  歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-20K09913
[Presentation] 短鎖脂肪酸誘導歯肉上皮細胞死にはヒストンアセチルトランスフェラーゼ活性優位の状況が必要である2019
- Author(s)
  津田啓方、室伏貴久、鈴木直人
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17K11686
[Presentation] トランススクリプトーム解析による短鎖脂肪酸誘導細胞死の誘導メカニズムの探索2019
- Author(s)
  津田啓方、室伏貴久、鈴木直人
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17K11686
[Presentation] 短鎖脂肪酸誘導オートファジー依存性細胞死による歯肉炎発症の可能性2017
- Author(s)
  津田啓方、室伏貴久、鈴木直人
- Organizer
  第２６回日本Cell Death学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11686
[Presentation] 歯周病細菌の産生する短鎖脂肪酸はヒト歯肉上皮細胞の細胞死を誘導し関節リウマチ関連因子を放出する2017
- Author(s)
  津田啓方、室伏貴久、鈴木直人
- Organizer
  第５９回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17K11686
[Presentation] Two histone methyltransferase inhibitors suppress osteoclast differentiation of Raw264.7 cells2014
- Author(s)
  HIROMASA TSUDA, ZHAO NING, AND NAOTO SUZUKI
- Organizer
  American association for dental research
- Place of Presentation
  Charotte, NC, USA
- Data Source
  KAKENHI-PROJECT-23593104
[Presentation] ヒストンメチルトランスフェラーゼ阻害剤はマウスマクロファージ様RAW264.7細胞のRANKL誘導破骨細胞分化を抑制する2014
- Author(s)
  津田啓方、鈴木直人
- Organizer
  口腔科学会総会
- Place of Presentation
  京王プラザホテル（東京）
- Data Source
  KAKENHI-PROJECT-23593104
[Presentation] Histone methyltransferase inhibition reduces RANKL-induced death of RAW264.7 cells2011
- Author(s)
  H Tsuda, K Imai, K Ochiai, N.Suzuki
- Organizer
  89^<th> General Session & Exhibition of the International Association for Dental Research.
- Place of Presentation
  Convention Center in San Diego (California, USA)
- Year and Date
  2011-03-18
- Data Source
  KAKENHI-PROJECT-21792160
[Presentation] Histone methyltransferase inhibition reduces RANKL-induced death of RAW264.7 cells2011
- Author(s)
  H Tsuda, K Imai, K Ochiai, N.Suzuki
- Organizer
  89^<th> General Session & Exhibition of the International Association for Dental Research Convention Center in San Diego
- Place of Presentation
  California, USA
- Year and Date
  2011-03-18
- Data Source
  KAKENHI-PROJECT-21792160
[Presentation] BIX01294はRAW264.7細胞のRANKL誘導破骨細胞分化を抑制する2011
- Author(s)
  津田啓方、今井健一、落合邦康、鈴木直人
- Organizer
  第53回歯科基礎医学会学術大会ならびに総会
- Place of Presentation
  長良川国際会議場、岐阜
- Year and Date
  2011-10-02
- Data Source
  KAKENHI-PROJECT-23592714
[Presentation] induces apoptosis and autophagic cell death2009
- Author(s)
  HIROMASA TSUDA Butyrate, bacterial metabolite
- Organizer
  87th International Association for Dental Research
- Place of Presentation
  Miami, FL, USA
- Year and Date
  2009-04-03
- Data Source
  KAKENHI-PROJECT-19791641
[Presentation] ヒストンメチルトランスフェラーゼG9a阻害剤はマウスマクロファージ様RAW264.7細胞のRANKL誘導破骨細胞分化を抑制する
- Author(s)
  津田啓方
- Organizer
  第２回幹細胞研究フォーラム
- Place of Presentation
  日本大学会館（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-23593104
[Presentation] BIX01294はRAW264.7細胞のRANKL誘導破骨細胞分化を抑制する
- Author(s)
  津田啓方
- Organizer
  第53回歯科基礎医学会学術大会・総会
- Place of Presentation
  長良川国際会議場（岐阜県）
- Data Source
  KAKENHI-PROJECT-23592714
[Presentation] ヒストンメチル化阻害はRAW264.7細胞のRANKL誘導破骨細胞分化を抑制する
- Author(s)
  津田啓方
- Organizer
  第２２回歯科医学会総会
- Place of Presentation
  インテックス大阪（大阪府大阪市）
- Data Source
  KAKENHI-PROJECT-23593104

1. Mikami Yoshikazu (80434075)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. SHINOZUKA Keiji (30431745)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. 鳥海拓 (40610308)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OCHIAI Kuniyasu (50095444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. IMAI Kenichi (60381810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. TAMURA Muneaki (30227293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 好士亮介 (80453877)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 上原範久 (30368211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 早津学 (40468898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 水谷祐輔 (40646238)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 福島敦史 (80415281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 外木守雄 (50217519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 市ノ川義美 (20203101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 花上伸明 (40385232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小原研心 (70598507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 白土博司 (50710844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 平田亮介 (00808735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 兼古晃輔 (40459342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 関谷秀樹 (70267540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Tsuda Hiromasa 津田 啓方

TSUDA Hiromasa 津田 啓方

Research Projects

Research Products

Co-Researchers

Development of a three-dimensional hard tissue culture system using inorganic polyphosphate and soft-tissue cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

スーパーエンハンサーを標的とする遺伝子発現制御による口腔癌発癌機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of human gingival organoid systems and investigation for the induction mechanisms of gingival inflammation and autoimmune diseases.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of highly sensitive diagnostic and therapeutic methods using exosomes as a new biomarker for oral cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the mechanism underlying secretory leukocyte protease inhibitor (SLPI)-induced malignancy of cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of prevention methods against periodontal-disease derived rheumatoid-arthritis using 3-demensional culture model of human gingival tissue.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of butyric acid producing bacteria on epigenetic gene regulation and systemic diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of periodontitis-preventive methods using epigenetically controling food ingredientPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of methods to prevent alveolar bone absorption during periodontitis using epigenetic regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of preventive methods from destruction of alveolar bone during periodontal disease using short chain fatty acidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Autophagy: Principles, Regulation and Roles in Disease2012

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Possible roles of short-chain fatty acids produced by oral bacteria in the development of alveolar osteitis2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Reactive oxygen species generation required for autophagy induction during butyrate- or propionate-induced release of damage-associated molecular patterns from dying gingival epithelial Ca9-22 cells2024

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Tsuda Hiromasa 津田啓方

TSUDA Hiromasa 津田啓方