NAKAO Haruhisa 中尾春壽

Researcher Number	60326139
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2018: 愛知医科大学, 医学部, 教授 2009: 愛知医科大学, 医学部, 教授 2008 – 2009: Aichi Medical University, 医学部, 准教授 2007: Nagoya City University, 大学院・医学研究科, 講師
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology / Epidemiology and preventive medicine
Keywords	Principal Investigator p53 / 細胞周期 / 肝癌 / 遺伝子ターゲッティング法 / CRISPR/Cas9 / 細胞増殖能 / 細胞老化 / 内在性遺伝子改変 / CRSPR/Cas9 / TP53遺伝子 … More / p53アイソフォーム / tumor suppression / cellular senescence / p53beta / delta133p53 / delta40p53 / 肝細胞癌 / p53 isoform / アポトーシス / p53β / p53α / CRSPR/CAS9 / isoform / AAV / 肝細胞 / 内在性遺伝子破壊 / knock-out / △N40p53 / 遺伝子ターゲッティング / TP53 / G1/S / p21 / delta-N40p53 / Akt / NS5A / HCV / apoptosis / Erk / Bad / hepatocellular carcinoma / EGF / ADAM … More Except Principal Investigator コリン欠乏食 / NASH / PCR / 種特異プライマー / 菌体抗原の精製 / 菌株の大量培養 / H. bilis / H. hepaticus / 血清 / 胆汁 / 疫学 / 血漿 / Helicobacter pylori / Helicobacter bilis / Helicobacter hepaticus / 血漿抗体価 / 全菌体抗原EIA法 / ブラシ検体 / ERCP / ヘリコバクター・ヘパティカス / ヘリコバクター・ビリス / ヘリコバクター・ピロリ / 全菌体抗原法 / ヘリコバクター・ピロリ感染 / ヘリコバクター・ヘパティカス感染 / ヘリコバクター・ビリス感染 / 胆道がん / 膵がん / 血漿抗体 / オリゴＣＧＨアレイ / オリゴCGHアレイ / 肝発癌 / 神経ペプチド / 肝病態 / 脂肪肝 / CRF / ストレス Less

The analysis of the p53 isoforms in hepatocellular carcinoma cells using endogenous gene modification.Principal Investigator
- Principal Investigator
  
  NAKAO HARUHISA
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University
Infection of Helicobacter and risk of pancreatic and biliary tract cancer
- Principal Investigator
  
  Kikuchi Shogo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Aichi Medical University
Cyclopedic investigation of genes for NASH-mediated carcinogenesis
- Principal Investigator
  
  YONEDA Masashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University
The analysis of checkpoint mechanism of cell cycle in liver cancer cellsPrincipal Investigator
- Principal Investigator
  
  NAKAO Haruhisa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University
Molecular analysis of the function of ADAM and the mechanism ofPrincipal Investigator
- Principal Investigator
  
  中尾春壽
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University
  Nagoya City University
The involvement of stress and central neuropeptide on the progression of nonalcoholic steatohepatitis
- Principal Investigator
  
  YONEDA Masashi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University

All 2018 2017 2016 2015 2014 2013 2012 2011 2009 2007

All Journal Article Presentation

[Journal Article] Delta40p53 suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells2017
- Author(s)
  Ota A, Nakao H, Sawada Y, Karnan S, Wahiduzzaman M, Inoue T, Kobayashi Y, Yamamoto T, Ishii N, Ohashi T, Nakade Y, Sato K, Itoh K, Konishi H, Hosokawa Y, Yoneda M
- Journal Title
  
  J Cell Sci
  
  Volume: 130 Issue: 3 Pages: 614-625
- DOI
  10.1242/jcs.190736
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460395, KAKENHI-PROJECT-15K19561, KAKENHI-PROJECT-16K09381, KAKENHI-PROJECT-17K09442, KAKENHI-PROJECT-17K07263
[Journal Article] Genome-wide association study-identified SNPs (rs3790844, rs3790843) in the NR5A2 gene and risk of pancreatic cancer in Japanese.2015
- Author(s)
  Ueno M, Ohkawa S, Morimoto M, Ishii H, Matsuyama M, Kuruma S, Egawa N, Nakao H, Mori M, Matsuo K, Hosono S, Nojima M, Wakai K, Nakamura K, Tamakoshi A, Takahashi M, Shimada K, Nishiyama T, Kikuchi S, Lin Y
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 17018-17018
- DOI
  10.1038/srep17018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293145
[Journal Article] Lack of associations between genetic polymorphisms in GSTM1, GSTT1 and GSTP1 and pancreatic cancer risk: a multi-institutional case-control study in Japan.2014
- Author(s)
  Yamada I, Matsuyama M, Ozaka M, Inoue D, Muramatsu Y, Ishii H, Junko U, Ueno M, Egawa N, Nakao H, Mori M, Matsuo K, Nishiyama T, Ohkawa S, Hosono S, Wakai K, Nakamura K, Tamakoshi A, Kuruma S, Nojima M, Takahashi M, Shimada K, Yagyu K, Kikuchi S, Lin Y.
- Journal Title
  
  Asian Pac J Cancer Prev.
  
  Volume: 15 Pages: 391-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293145
[Journal Article] Combined arsenic trioxide-cisplatin treatment enhances apoptosis in oral squamous cell carcinoma cells2014
- Author(s)
  Nakaoka T, Ota A, Ono T, Karnan S, et al.
- Journal Title
  
  Cell Oncol (Dordr)
  
  Volume: 37 Pages: 119-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590996
[Journal Article] Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk : a case-control study in Japan2013
- Author(s)
  Lin Y, Ueda J, Yagyu K, Nakao H, et al.
- Journal Title
  
  BMC Cancer
  
  Volume: 13 Pages: 337-337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590996
[Journal Article] Hepatocarcinogenesis in NASH2012
- Author(s)
  Nakade Y, Sato K, Nakao H, et al.
- Journal Title
  
  Gan To Kagaku Ryoho
  
  Volume: 39 Pages: 693-7
- Data Source
  KAKENHI-PROJECT-23590996
[Journal Article] Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis.2012
- Author(s)
  Tamaki Y, Nakade Y, Yamauchi T, Makino Y, Yokohama S, Okada M, Aso K, Kanamori H, Ohashi T, Sato K, Nakao H, Haneda M, Yoneda M
- Journal Title
  
  J Gastroenterol
  
  Volume: Aug 14 Pages: 491-503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590996
[Journal Article] NASHにおける肝発癌(総説)2012
- Author(s)
  中出幸臣、佐藤　顕、中尾春壽、米田政志
- Journal Title
  
  癌と化学療法
  
  Volume: 39 Pages: 693-967
- Data Source
  KAKENHI-PROJECT-23590996
[Journal Article] 若年者に発症した石灰乳胆汁による閉塞性黄疸に対し、EPBDが奏功した1例2012
- Author(s)
  足立和規、田中創始、小林佑次、林伸彦、石井紀光、金澤太茂、佐々木誠人、中尾春壽、春日井邦夫、米田政志
- Journal Title
  
  Gastroenterological Endoscopy
  
  Volume: 54 Pages: 466-473
- NAID
  10030294075
- Data Source
  KAKENHI-PROJECT-23590996
[Journal Article] Liver stiffness measurement using transient elastography and hepatocellular carcinoma.2011
- Author(s)
  Nakao H, Yoneda M.
- Journal Title
  
  Hepatology Research
  
  Volume: 41 Pages: 921-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590996
[Journal Article] Liver stiffness measurement using transient elastography and hepatocellular carcinoma2011
- Author(s)
  Nakao H, Yoneda M.
- Journal Title
  
  Hepatol Res
  
  Volume: 41 Pages: 921-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590996
[Journal Article] An overview of genetic polymorphisms and pancreatic cancer risk in molecular epidemiologic studies2011
- Author(s)
  Lin Y, Yagyu K, Egawa N, Nakao H, et al.
- Journal Title
  
  J Epidemiol
  
  Volume: 21 Pages: 2-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590996
[Journal Article] The intertwisted correlations among non-alcoholic fatty liver disease, atherosclerosis, and metabolic syndrome.2009
- Author(s)
  Nakao H, Yoneda M
- Journal Title
  
  J Gastroenterol 44
  
  Pages: 1162-1164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590787
[Journal Article] Effect of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis C virus infection.2009
- Author(s)
  Nojiri S, Nakao H, Sugauchi F, Miyaki T, Senda K, Sasaki M, et al.
- Journal Title
  
  Hepatol Res 39
  
  Pages: 21-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590787
[Journal Article] Effect of plaunotol in combination with clarithromycin against clarithromycin-resistant Helicobacter pylori in vitro and in vivo.2007
- Author(s)
  Sasaki M, Mizoshita T, Mizushima T, Inoue H, Kamiya T, Nakao H, et al.
- Journal Title
  
  J Antimicrob Chemother 60
  
  Pages: 1060-1063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590787
[Journal Article] Advantages of endoscopic submucosal dissection over conventional endoscopic mucosal resection.2007
- Author(s)
  Shimura T, Sasaki M, Kataoka H, Tanida S, Oshima T, Nakao H, et al.
- Journal Title
  
  J Gastroenterol Hepatol 22
  
  Pages: 821-826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590787
[Presentation] Delta40p53 suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells.2018
- Author(s)
  Haruhisa Nakao, Akinobu Ota, Yumi Sawada, Sivasundaram Karnan, Md Wahiduzzaman, Tadashi Inoue, Yuji Kobayashi,Norimitsu Ishii, Tomohiko Ohashi, Yukiomi Nakade, Yoshio Sumida, Kiyoaki Itoh, Hiroyuki Konishi, Yoshitaka Hosokawa, Masashi Yoneda
- Organizer
  the European Association for the Study of Liver: The International Liver Congress 2018 in Paris
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09381
[Presentation] 内在性遺伝子改変法を用いた肝癌におけるp53 splicing isoformの機能解析2018
- Author(s)
  中尾春壽 , 太田明伸 , 北野礼奈 , 坂本和賢 , 大橋知彦 , 中出幸臣 , 角田圭雄 , 伊藤清顕 , 米田政志
- Organizer
  第54回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K09381
[Presentation] Delta133p53, One of the p53 Isoforms, Suppresses Tumor Cell Proliferation and Induces Cellular Senescence in Hepatocellular Carcinoma Cells2018
- Author(s)
  Haruhisa Nakao, Akinobu Ota, Mayu Ibusuki, Rena Kitano, Satoshi Kimoto, Tomohiko Ohashi, Yukiomi Nakade, Yoshio Sumida, Kiyoaki Itoh, Hiroyuki Konishi, Yoshitaka Hosokawa, Masashi Yoneda
- Organizer
  the American Association for the Study of Liver Diseases. : The Liver Meeting® 2018 in San Francisco
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09381
[Presentation] delta40p53（p53蛋白質splicing isoform）の肝細胞癌における機能解析2017
- Author(s)
  中尾春壽、太田明伸、坂本和賢、山本高也、大橋知彦、中出幸臣、角田圭雄、伊藤清顕、米田政志
- Organizer
  第53回日本肝臓学会　総会
- Data Source
  KAKENHI-PROJECT-16K09381
[Presentation] 遺伝子ターゲティング法を用いたp53蛋白質splicing isoformの肝細胞癌における機能解析2016
- Author(s)
  中尾春壽、太田明伸、山本高也
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  千葉
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K09381
[Presentation] When one door shuts, another opens; TP53 gene knock out cells and △N40p532014
- Author(s)
  中尾　春壽
- Organizer
  第15回桜山消化器病病態研究会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-23590997
[Presentation] ADAM17 promotes ERK-mediated phosphorylation of Serl 12 in Bad.2007
- Author(s)
  Katsuhiro Senda, Haruhisa Nakao, et. al.
- Organizer
  The American Association for the Study of Liver Diseases 55th Annual Meetiing.
- Place of Presentation
  Boston(USA)
- Year and Date
  2007-11-06
- Data Source
  KAKENHI-PROJECT-19590782
[Presentation] ADAM17 promotes ERK-mediated phosphorylation of Ser112 in Bad2007
- Author(s)
  Senda K, Nakao H., Nojiri S, Joh T, Miyaki T.
- Organizer
  The American Association for the Study of Liver Diseases 55th Annual Meetiing
- Place of Presentation
  Boston (USA)
- Year and Date
  2007-11-06
- Data Source
  KAKENHI-PROJECT-19590782

1. NAKADE Yukiomi (70431400)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. YONEDA Masashi (30261407)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. SHIBASUN Daran Karunan (30557096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KONISHI Hiroyuki (20344335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Kikuchi Shogo (40224901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. OSAKI Takako (90255406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. LIN Yingsong (50340302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 折戸悦朗 (60204294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 神谷茂 (10177587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 上野誠 (10520760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 森満 (50175634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 来間佐和子 (90627639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 笹平直樹 (30401102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 奥田真珠美 (40531091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 福田能啓 (60148640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 石井浩 (70521855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 太田明伸 (30438048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
18. 稲熊真悟 (80410786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. DAN Naoaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. EGAWA Naoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. 細川好孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKAO Haruhisa 中尾 春壽

Research Projects

Research Products

Co-Researchers

The analysis of the p53 isoforms in hepatocellular carcinoma cells using endogenous gene modification.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Infection of Helicobacter and risk of pancreatic and biliary tract cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cyclopedic investigation of genes for NASH-mediated carcinogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of checkpoint mechanism of cell cycle in liver cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular analysis of the function of ADAM and the mechanism ofPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The involvement of stress and central neuropeptide on the progression of nonalcoholic steatohepatitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Delta40p53 suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide association study-identified SNPs (rs3790844, rs3790843) in the NR5A2 gene and risk of pancreatic cancer in Japanese.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lack of associations between genetic polymorphisms in GSTM1, GSTT1 and GSTP1 and pancreatic cancer risk: a multi-institutional case-control study in Japan.2014

Author(s)

Journal Title

Data Source

[Journal Article] Combined arsenic trioxide-cisplatin treatment enhances apoptosis in oral squamous cell carcinoma cells2014

Author(s)

Journal Title

Data Source

[Journal Article] Association between variations in the fat mass and obesity-associated gene and pancreatic cancer risk : a case-control study in Japan2013

Author(s)

Journal Title

Data Source

[Journal Article] Hepatocarcinogenesis in NASH2012

Author(s)

Journal Title

Data Source

[Journal Article] Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis.2012

Author(s)

Journal Title

Data Source

[Journal Article] NASHにおける肝発癌(総説)2012

Author(s)

Journal Title

Data Source

[Journal Article] 若年者に発症した石灰乳胆汁による閉塞性黄疸に対し、EPBDが奏功した1例2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Liver stiffness measurement using transient elastography and hepatocellular carcinoma.2011

NAKAO Haruhisa 中尾春壽