Hayashi Mutsumi 林睦

… Alternative Names

HAYASHI Mutsumi 林睦

林睦ハヤシムツミ

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Researcher Number	60327575
Other IDs
Affiliation (Current)	2025: 埼玉医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2024: 埼玉医科大学, 医学部, 助教 2023: 慶應義塾大学, 医学部(信濃町), 助教 2021 – 2022: 慶應義塾大学, 医学部(信濃町), 特任助教 2018 – 2020: 慶應義塾大学, 医学部(信濃町), 助教 2017: 慶應義塾大学, 医学部, 助教 … More 2016: 慶應義塾大学, 医学部(信濃町), 特任助教 2013: 慶應義塾大学, 医学部, 特任助教 2011: 慶應義塾大学, 医学部, 特任助教 2010: 慶應義塾大学, 医学部, 助教 2005 – 2006: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Human pathology / Pediatrics Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / Experimental pathology / Human pathology
Keywords	Principal Investigator 癌 / 白血病 / 小児悪性腫瘍 / RNAポリメラーゼII / 抗体薬剤複合体 / 抗体医薬 / CD26 / 遺伝子 / 病理学 / 細胞・組織 … More / 遺伝子再構成 / MLL遺伝子再構成 / SCIDマウス / NOD / 播種性血管内凝固症候群 … More Except Principal Investigator 核移行 / がん / モノクローナル抗体 / スーパーエンハンサー / RNAポリメラーゼII / CD26 / Antibody-Drug Conjugate / 抗体療法 / 抗体 / 分子標的療法 / 病理学 / carcinoma / Neurodegeneration / enhancer / pathology / phase separation / 抗体薬剤複合体 / scFV / 免疫担当細胞 / がん細胞 / single chain Fv / 核内移行 / 抗体抗がん剤結合薬ADC / ChIPseq法 / 病理検体 / FFPE / クロマチン免疫沈降塩基配列決定法 / ホルマリン固定パラフィン包埋組織 / RNAポリメラーゼⅡ / 抗体薬物複合体 / トランスレーショナルリサーチ / 癌 / アレルギー・ぜんそく / 自然免疫 / メタボリック症候群 / 免疫学 Less

Effect analysis of a novel anti-CD26 theraputic antibody in pediatric malignant tumorsPrincipal Investigator
- Principal Investigator
  
  林睦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Saitama Medical University
Challenge to phase separation pathology
- Principal Investigator
  
  山田健人
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Saitama Medical University
Development of transportable scFV monoclonal antibody into nucleus
- Principal Investigator
  
  Yamada Taketo
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Saitama Medical University
Development of ChIPseq method using pathological specimens and identification of disease-specific super-enhancer
- Principal Investigator
  
  Yamada Taketo
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Saitama Medical University
Novel anti-cancer therapy against super-enhancer using humanized monoclonal antibody with transportation activity into nucleus
- Principal Investigator
  
  YAMADA TAKETO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Saitama Medical University
Novel therapy against human cancers using intra-nuclear transportable humanized monoclonal antibody against CD26.
- Principal Investigator
  
  YAMADA TAKETO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Saitama Medical University
Development of molecular targeting therapy using nuclear-transpoted humanized monoclonal antibody
- Principal Investigator
  
  YAMADA Taketo
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Human natural helper cells and its involvement in diseases
- Principal Investigator
  
  YAMADA TAKETO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
Partial tandem duplication in childhood acute myeloblastic leukemia and molecular targeted therapyPrincipal Investigator
- Principal Investigator
  
  HAYASHI Mutsumi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
小児急性骨髄性白血病の動物モデルを用いたDIC発症の分子機構の解析Principal Investigator
- Principal Investigator
  
  林睦
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Keio University

All 2024 2023 2022 2021 2019 2018 2017 2016 2013 2012 2010 2007

All Journal Article Presentation

[Journal Article] HDAC Inhibition Induces CD26 Expression on Multiple Myeloma Cells via the c-Myc/Sp1-mediated Promoter Activation2024
- Author(s)
  Nishida H, Suzuki R, Nakajima K, Hayashi M, Morimoto C, Yamada T
- Journal Title
  
  Cancer Res Commun
  
  Volume: 4(2) Issue: 2 Pages: 349-364
- DOI
  10.1158/2767-9764.crc-23-0215
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07682, KAKENHI-PROJECT-22K19387, KAKENHI-PROJECT-23K27395
[Journal Article] Novel antibody-drug conjugate with anti-CD26 humanized monoclonal antibody and transcription factor IIH (TFIIH) inhibitor, triptolide, inhibits tumor rrowth via impairing mRNA synthesis2019
- Author(s)
  Hayashi M, Madokoro H, Yamada K, Nishida H, Morimoto C, Sakamoto M, Yanagawa H, Yamada T
- Journal Title
  
  Cancers
  
  Volume: 11 Issue: 8 Pages: 1138-1138
- DOI
  10.3390/cancers11081138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22542, KAKENHI-PROJECT-18K15253, KAKENHI-PROJECT-19H03519
[Journal Article] CD26 is a potential therapeutic target by humanized monoclonal antibody for the treatment of multiple myeloma2018
- Author(s)
  Hiroko Nishida, Mutsumi Hayashi, Chikao Morimoto, Michiie Sakamoto, Taketo Yamada
- Journal Title
  
  Blood Cancer Journal
  
  Volume: 8(99) Issue: 11 Pages: 1-17
- DOI
  10.1038/s41408-018-0127-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07180, KAKENHI-PROJECT-16H04714, KAKENHI-PROJECT-16H05345
[Journal Article] A humanized anti-CD26 monoclonal antibody inhibits cell growth of malignant mesothelioma via retarded G2/M cell cycle transition.2016
- Author(s)
  Hayashi M, Madokoro H, Yamada K, Nishida H, Morimoto C, Sakamoto M, Yamada T.
- Journal Title
  
  Cancer Cell International
  
  Volume: 30 Issue: 1 Pages: 35-35
- DOI
  10.1186/s12935-016-0310-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04714, KAKENHI-PROJECT-16H05345, KAKENHI-PROJECT-16K07180
[Journal Article] Nuclear localization of CD26 induced by a humanized monoclonal antibody inhibits tumor cell growth by modulating of POLR2A transcription2013
- Author(s)
  Yamada K, Hayashi M, Madokoro H, Nishida H, Du W, Ohnuma K, Sakamoto M, Morimoto C, Yamada T
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 4 Pages: e62304-e62304
- DOI
  10.1371/journal.pone.0062304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21679005, KAKENHI-PROJECT-24659401, KAKENHI-PROJECT-25430157, KAKENHI-PROJECT-25670195
[Journal Article] Establishment of a novel childhood acute myeloid leukaemia cell line, KOPM-88 containing partial tandem duplication of the MLL gene and an in vivo model for childhood acute myeloid leukaemia using NOD/SCID mice.2007
- Author(s)
  Hayashi M, Kondoh K, Nakata Y, Kinoshit A, Mori T, Takahashi T, Sakamoto MI, Yamada T
- Journal Title
  
  Br J Haematol 137(3)
  
  Pages: 221-232
- Data Source
  KAKENHI-PROJECT-16790588
[Presentation] 核内移行する抗CD26ヒト化モノクローナル抗体を用いた新規抗体薬剤複合体の橋渡し研究2023
- Author(s)
  林　睦、間所裕子、山田健人
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-22K19387
[Presentation] CD26陽性がんに対する新規抗体-抗がん剤結合分子ADCの開発2022
- Author(s)
  林　睦、間所裕子、坂元亨宇、山田健人
- Organizer
  第111回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-22K19387
[Presentation] Nuclear Transportable ADC with Triptolide Inhibits Tumor Cell Growth via Impaired Super-enhancer Function2021
- Author(s)
  Yamada T, Hayashi M
- Organizer
  The 80th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-19H03519
[Presentation] Anti-CD26 humanized antibody-triptolide conjugate trasnports into nucleus and inhibits RNA polymerase II activity2019
- Author(s)
  山田健人、坂元亨宇、森本幾夫、林睦
- Organizer
  第78回日本癌学会総会（
- Data Source
  KAKENHI-PROJECT-19K22542
[Presentation] Anti-CD26 humanized antibody-triptolide conjugate trasnports into nucleus and inhibits RNA polymerase II activity2019
- Author(s)
  山田健人、坂元亨宇、森本幾夫、林睦
- Organizer
  第78回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-19H03519
[Presentation] Anti-CD26 Humanized Monoclonal Antibody Conjugated to Triptolide Inhibits Tumor Cell Growth via Transportation into Nucleus and Impaired RNA Polymerase II2019
- Author(s)
  Hayashi M,Madokoro H, Yamada T
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22542
[Presentation] Anti-CD26 Humanized Monoclonal Antibody Conjugated to Triptolide Inhibits Tumor Cell Growth via Transportation into Nucleus and Impaired RNA Polymerase II2019
- Author(s)
  Hayashi M,Madokoro H, Yamada T
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03519
[Presentation] Anti-CD26 humanized antibody-triptolide conjugate moves into nucleus and impairs RNA polymerase II.2018
- Author(s)
  Yamada T, Madokoro H, Yamada K, Nishida H,　Morimoto C,　Sakamoto M, Hayashi M.
- Organizer
  第107回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-16H04714
[Presentation] Anti-CD26 Humanized Monoclonal Antibody Conjugated To Triptolide Inhibits Mesothelioma Cell Growth Via Transportation Into Nucleus And Impaired RNA Polymerase II.2018
- Author(s)
  Yamada T, Madokoro H, Yamada K, Nishida H,　Morimoto C,　Sakamoto M, Hayashi M.
- Organizer
  The 6th JCA-AACR Special Joint Conference, The Latest Advances in Lung Cancer Research: From Basic Science to Therapeutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04714
[Presentation] Anti-tumor effects of humanized anti-CD26 monoclonal antibody against hepatocellular carcinoma.2017
- Author(s)
  Yamada T, Madokoro H, Yamada K, Nishida H,　Morimoto C,　Sakamoto M, Hayashi M.
- Organizer
  第106回日本病理学会総会（東京）
- Data Source
  KAKENHI-PROJECT-16H04714
[Presentation] Humanized anti-CD26 monoclonal antibody, YS110, has anti-myeloma efficacy for the treatment of high-risk multiple myeloma2017
- Author(s)
  Nishida H, Hayashi M, Morimoto C, Sakamoto M, Yamada T.
- Organizer
  the 59th American Society of Hematology Annual Meeting and Exposition. (Atlanta, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04714
[Presentation] Humanized anti-CD26 monoclonal antibody has a therapeutic potentiality against multiple myeloma.2017
- Author(s)
  Nishida H, Hayashi M, Morimoto C, Sakamoto M, Yamada T.
- Organizer
  第79回日本血液学会総会（東京）
- Data Source
  KAKENHI-PROJECT-16H04714
[Presentation] Anti-CD26 humanized monoclonal antibody conjugated to triptolide is transported into nucleus and impairs RNA polymerase II.2017
- Author(s)
  Yamada T, Madokoro H, Nishida H,Morimoto C,Sakamoto M, Hayashi M.
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）（神戸）
- Data Source
  KAKENHI-PROJECT-16H04714
[Presentation] Humanized anti-CD26 antibody conjugated with RNA polymerase II inhibitor Triptolide suppresses tumor2016
- Author(s)
  林睦、間所裕子、山田幸司、西田浩子、坂元亨宇、森本幾夫、山田健人
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-16H04714
[Presentation] ヒト化CD26モノクローナル抗体によるがん抗体療法とその分子機構2013
- Author(s)
  山田健人、山田幸司、林睦、西田浩子、間所裕子、坂元亨宇
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25670195
[Presentation] ヒト化CD26モノクローナル抗体によるがん抗体療法とその分子機構2013
- Author(s)
  山田健人、山田幸司、林　睦、西田浩子、間所裕子、坂元亨宇
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  ロイトン札幌（北海道）
- Data Source
  KAKENHI-PROJECT-25670195
[Presentation] ヒト化CD26モノクローナル抗体による中皮腫の抗体療法の分子機構: CD26核移行と転写調節を介して2012
- Author(s)
  山田幸司、林睦、坂元亨宇、森本幾夫、山田健人
- Organizer
  第101回病理学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-28
- Data Source
  KAKENHI-PROJECT-22790355
[Presentation] ヒト化抗CD26モノクローナル抗体による中皮腫の抗体療法の分子機構:細胞周期調節による抗腫瘍作用2012
- Author(s)
  林睦、山田幸司、坂元亨宇、森本幾夫、山田健人
- Organizer
  第101回病理学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-28
- Data Source
  KAKENHI-PROJECT-22790355
[Presentation] Humanized anti-CD26 monoclonal antibody therapy against mesothelioma and its molecular mechanisms2010
- Author(s)
  Mutsumi Hayashi, Kohji Yamada, Wenlin Du, Michiie Sakamoto, Chikao Morimoto, Taketo Yamada
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22790355
[Presentation] Humanized anti-CD26 monoclonal antibody therapy against mesothelioma and its molecular mechanisms.2010
- Author(s)
  Mutsumi Hayashi, Kohji Yamada, Wenlin Du, Michiie Sakamoto, Chikao Morimoto, Taketo Yamada
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22790355
[Presentation] CD26と抗CD26抗体の細胞膜-核間輸送機構とその機能2010
- Author(s)
  山田幸司、林睦、坂元亨宇、森本幾夫、山田健人
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22790355
[Presentation] ヒト化抗CD26モノクローナル抗体を用いた悪性中皮腫の新規治療法の基礎的検討2010
- Author(s)
  林睦、山田幸司、杜ぶん林、坂元亨宇、山田健人
- Organizer
  第99回病理学会総会
- Place of Presentation
  東京
- Year and Date
  2010-04-28
- Data Source
  KAKENHI-PROJECT-22790355

1. YAMADA TAKETO (60230463)

# of Collaborated Projects: 8 results

# of Collaborated Products: 20 results
2. NISHIDA Hiroko (80317130)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
3. 山田幸司 (90570979)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
4. OHNUMA Kei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Mutsumi 林 睦

HAYASHI Mutsumi 林 睦

林 睦 ハヤシ ムツミ

Research Projects

Research Products

Co-Researchers

Effect analysis of a novel anti-CD26 theraputic antibody in pediatric malignant tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Challenge to phase separation pathology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of transportable scFV monoclonal antibody into nucleus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of ChIPseq method using pathological specimens and identification of disease-specific super-enhancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel anti-cancer therapy against super-enhancer using humanized monoclonal antibody with transportation activity into nucleus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel therapy against human cancers using intra-nuclear transportable humanized monoclonal antibody against CD26.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of molecular targeting therapy using nuclear-transpoted humanized monoclonal antibody

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Human natural helper cells and its involvement in diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Partial tandem duplication in childhood acute myeloblastic leukemia and molecular targeted therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小児急性骨髄性白血病の動物モデルを用いたDIC発症の分子機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] HDAC Inhibition Induces CD26 Expression on Multiple Myeloma Cells via the c-Myc/Sp1-mediated Promoter Activation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel antibody-drug conjugate with anti-CD26 humanized monoclonal antibody and transcription factor IIH (TFIIH) inhibitor, triptolide, inhibits tumor rrowth via impairing mRNA synthesis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD26 is a potential therapeutic target by humanized monoclonal antibody for the treatment of multiple myeloma2018

Author(s)

Journal Title

DOI

Hayashi Mutsumi 林睦

HAYASHI Mutsumi 林睦

林睦ハヤシムツミ