Shima Fumi 島扶美

… Alternative Names

SHIMA Fumi 島扶美

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Researcher Number	60335445
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2019 – 2023: 神戸大学, 科学技術イノベーション研究科, 教授 2016: 神戸大学, 大学院科学技術イノベーション研究科, 教授 2016: 神戸大学, 学内共同利用施設等, 教授 2016: 神戸大学, 科学技術イノベーション研究科, 教授 2014 – 2016: 神戸大学, 医学(系)研究科(研究院), 教授 … More 2013: 神戸大学, 医学研究科, 准教授 2011 – 2013: 神戸大学, 医学(系)研究科(研究院), 准教授 2011: 神戸大学, 医学研究科, 准教授 2010: 神戸大学, 医学研究科, 講師 2010: Kobe University, 大学院・医学研究科, 講師 2008 – 2009: Kobe University, 医学研究科, 助教 2008 – 2009: 神戸大学, 大学院・医学研究科, 助教 2007: 神戸大学, 大学院・医学系研究科, 助教 2007: Kobe University, 大学院医学系研究科, 助教 2005 – 2006: 神戸大学, 大学院医学系研究科, 助手 2001 – 2005: 神戸大学, 大学院・医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator General medical chemistry / Complex systems / Biological Sciences / Basic Section 43020:Structural biochemistry-related / Drug development chemistry / General medical chemistry Except Principal Investigator General medical chemistry / Biological Sciences / General medical chemistry
Keywords	Principal Investigator シグナル伝達 / 核磁気共鳴法 / 低分子量G蛋白質 / Ｘ線自由電子レーザー / 分子動画 / がん / 癌 / 高速分子動画 / Ras癌遺伝子 / 創薬 … More / インシリコ / ras癌遺伝子 / X線結晶構造解析 / 分子標的薬 / switch I / M-Ras / がん化シグナル伝達 / 時分割構造解析 / rasがん遺伝子産物 / 構造ベース創薬 / X線自由電子レーザー / Ｘ線結晶構造解析 / がん遺伝子産物 / がん遺伝子 / 医薬分子設計 / rasがん遺伝子 / 分子認識 / ^<31>P-核磁気共鳴法 / NMR / X線結晶解析 / M-Ras(R-Ras3) / in silico創薬 / 抗癌剤開発 / ras癌遺伝子産物 / switch II / 位相 / 分子置換法 / 蒸気拡散法 / RA-GEF2 / Rap-associating domain / Ras / GTPase活性 / switch2 / switch1 … More Except Principal Investigator 低分子量G蛋白質 / ホスホリパーゼC / ノックアウトマウス / Ras蛋白質 / イノシトール脂質代謝 / knockout mice / Ras protein / small G protein / phospholipase C / 心臓半月弁膜症 / 線虫 / Rap1蛋白質 / シグナル伝達 / Rap1 / グアニンヌクレオチド交換因子 / グアニンヌクレオチド交換促進因子 / RAドメイン / X線結晶解析 / 化学発癌 / rap1癌抑制遺伝子 / ras癌遺伝子 / transgenic mice / cancer promotion / inflammation / inositol phospholipid signaling / トランスジェニックマウス / トランスジュニックマウス / 発癌プロモーション / 炎症反応 / nematodes / semilunar valve disease / ventricular dilation / phosphoinositide signaling / 半月弁狭窄 / 半月弁逆流 / 心室拡張 / Caenorhabditis elegans / Knockout Mice / Rap1 Protein / Ras Protein / Intracellular Signal Transduction / Small G Proteins / Inositol Signaling / Phospholipase C / ゴルジ装置 / 神経系幹細胞 / Ras / 低分子量GTP結合蛋白質 / 細胞内情報伝達 / 高分子構造・物性 / 脂質 / 癌 / 蛋白質 / ホスホリパーゼＣ / 表皮角化細胞 / サイトカイン / 発癌 / 炎症 / 癲癇 / Rapl / 癩癇 / 雄性不妊 / 精子形成異常 / 帯状異所性灰白質症 / 神経細胞移動 / 血管形成 / イン・シリコ創薬 / rap1がん抑御遺伝子 / ボスホリパーゼC / インシリコ創薬 / 化学発がん / rap1がん抑制遺伝子 / rasがん遺伝子 / raf癌遺伝子 / シクラーゼ結合蛋白質 / ファルネシル化 / アデニル酸シクラーゼ / M-Ras / 細胞増殖因子 / 細胞内局在 / 心臓半月弁弁膜症 / ホルボールエステル Less

Elucidation of cancer signal transduction mechanism using photo-controllable Ras on an atomic scalePrincipal Investigator
- Principal Investigator
  
  島扶美
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kobe University
Time-resolved structural analysis of small GTPase Ras signaling transduction by utilizing caged-GTP-coupled Ras proteinPrincipal Investigator
- Principal Investigator
  
  島扶美
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kobe University
Atomic-scale dynamic structural analysis of Ras by SACLA, which provide promising information on designing cancer therapeutic agentsPrincipal Investigator
- Principal Investigator
  
  Shima Fumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Kobe University
Research on the molecular basis of conformational dynamics of oncogene product Ras for application to the development of its specific inhibitorsPrincipal Investigator
- Principal Investigator
  
  shima fumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe University
Structural study on the role of post-translational lipid modifications of the small G protein Ras
- Principal Investigator
  
  KATAOKA TOHRU
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Elucidation of a novel signaling pathway responsible for the roles of phospholipase Cepsilon in augmentation of inflammation and carcinogenesis
- Principal Investigator
  
  KATAOKA TOHRU
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Development of anti-cancer drugs having Ras-Raf-binding inhibitory activityPrincipal Investigator
- Principal Investigator
  
  SHIMA fumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
低分子量G蛋白質の高次構造多型性のシグナル伝達における意義Principal Investigator
- Principal Investigator
  
  島扶美
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Analysis of the function of Rap1-activating factors which mediate the cross-talks between different species of small G proteins
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Anti-cancer drug design targeting a novel tertiary structure of ras oncogene productPrincipal Investigator
- Principal Investigator
  
  SHIMA Fumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
低分子量G蛋白質の高次構造多型性のシグナル伝達における意義Principal Investigator
- Principal Investigator
  
  島扶美
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Mechanism of cell growth regulation by small G proteins
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Elucidation of the in vivo function of the Ras/Rap effector phospholipase Cε
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Ras/Rap結合(RA)ドメインによるGTP結合蛋白質認識機構の解明Principal Investigator
- Principal Investigator
  
  島扶美
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Analysis of the Regulatory Mechanism and Function of a Novel Class of Phospholipase C, PLCε
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Ras/Rap1A結合(RA)ドメインのGTP結合蛋白質認識機構の解明Principal Investigator
- Principal Investigator
  
  島扶美
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Analysis of the Function of a Novel Class of Mammalian Phospholipase C, PLCε
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
低分子量G蛋白質による細胞増殖の制御機構
- Principal Investigator
  
  KATAOKA Tohru
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University

[Book] がん分子標的治療2015
- Author(s)
  Fumi Shima, Yoko Yoshikawa, Higeyuki Matsumoto, Tohru Kataoka
- Total Pages
  166
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-26293026
[Book] SPring-8 Research Frontiers 20132014
- Author(s)
  Fumi Shima, Tohru Kataoka
- Total Pages
  154
- Publisher
  SPring-8/JASRI
- Data Source
  KAKENHI-PROJECT-26293065
[Book] Discovery of small-molecule Ras inhibitors that display antitumor activity by in terfering with Ras•GTP-effector interaction.Inhibitors of the R as superfamily G-proteins (Tamanoi, F. and Der, C. J., eds. Elsevier)2013
- Author(s)
  Shima, F., Yoshikawa, Y., Matsumoto, S., Kataoka, T.
- Publisher
  The Enzymes
- Data Source
  KAKENHI-PROJECT-23590336
[Book] The Enzymes vol. 34, Inhibitors of the Ras superfamily G-proteins2013
- Author(s)
  Shima, F., Yoshikawa, Y., Matsumoto, S., and Kataoka, T.
- Total Pages
  23
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-23590336
[Book] The Enzymes Vol. 34 Inhibitors of the Ras superfamily G-proteins, Part B2013
- Author(s)
  Fumi Shima, Yoko Yoshikawa, Shigeyuki Matsunoto, Tohru Kataoka
- Publisher
  Elsevier Inc.
- Data Source
  KAKENHI-PROJECT-23390071
[Book] The Enzymes Vol. 34 Inhibitors of the Ras superfamily G-proteins2013
- Author(s)
  Shima, F., Yoshikawa, Y., Matsumoto, S., and Kataoka, T
- Publisher
  Part B (Elsevier)
- Data Source
  KAKENHI-PROJECT-23390071
[Journal Article] Molecular Mechanism for Conformational Dynamics of Ras·GTP Elucidated from In-Situ Structural Transition in Crystal.2016
- Author(s)
  Matsumoto S, Miyano N, Baba S, Liao J, Kawamura T, Tsuda C, Takeda A, Yamamoto M, Kumasaka T, Kataoka T, Shima F.
- Journal Title
  
  Sci Rep.
  
  Volume: - Issue: 1
- DOI
  10.1038/srep25931
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293026, KAKENHI-PROJECT-26293065
[Journal Article] Integrin-α10 dependency identifies RAC and RICTOR as therapeutic targets in high-grade myxofibrosarcoma.2016
- Author(s)
  Okada T, Lee AY, Qin LX, Agaram N, Mimae T, Shen Y, O'Connor R, López-Lago MA, Craig A, Miller ML, Agius P, Molinelli E, Socci ND, Crago AM, Shima F, Sander C, Singer S.
- Journal Title
  
  Cancer Discov.
  
  Volume: 6 Issue: 10 Pages: 1148-1165
- DOI
  10.1158/2159-8290.cd-15-1481
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293026
[Journal Article] Current status of the development of Ras inhibitors.2015
- Author(s)
  Fumi Shima, Shigeyuki Matsumoto, Yoko Yoshikawa, Takashi Kawamura, Masayuki Isa, Tohru Kataoka
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 158 Issue: 2 Pages: 91-99
- DOI
  10.1093/jb/mvv060
- NAID
  40020554051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293065
[Journal Article] rasがん遺伝子産物Rasを分子標的としたがん治療薬開発の現状2015
- Author(s)
  島扶美、吉川陽子、松本篤幸、片岡徹
- Journal Title
  
  がん分子標的治療
  
  Volume: 13巻 Pages: 92-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293065
[Journal Article] Current statue of the development of Ras inhibitors2015
- Author(s)
  Shima F, Matsumoto S, Yoshikawa Y, Kawamura T, Isa M, Kataoka T
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 158 Pages: 91-99
- NAID
  40020554051
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293026
[Journal Article] rasがん遺伝子産物の新規立体構造情報を利用した分子標的がん治療薬の開発2014
- Author(s)
  島扶美、熊坂崇、松本篤幸、吉川陽子、山本雅貴、片岡徹
- Journal Title
  
  日本放射光学会誌　放射光
  
  Volume: 27 Pages: 3-9
- NAID
  40019965771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590336
[Journal Article] rasがん遺伝子産物の新規立体構造情報を利用した分子標的がん治療薬の開発2014
- Author(s)
  島扶美, 熊坂崇, 松本篤幸, 吉川陽子, 山本雅貴, 片岡徹
- Journal Title
  
  日本放射光学会誌放射光
  
  Volume: 27(1) Pages: 3-9
- NAID
  40019965771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590336
[Journal Article] In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction2013
- Author(s)
  Fumi Shima
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390071
[Journal Article] In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.2013
- Author(s)
  Shima F, Yoshikawa Y, Ye M, Araki M, Matsumoto S, Liao J, Hu L, Sugimoto T, Ijiri Y, Takeda A, Nishiyama Y, Sato C, Muraoka S, Tamura A, Osoda T, Tsuda KI, Miyakawa T, Fukunishi H, Shimada J, Kumasaka T, Yamamoto M, Kataoka T.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A.
  
  Volume: 110 Pages: 8182-8187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590336
[Journal Article] In silico discovery of novel small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction2013
- Author(s)
  Shima, F., Yoshikawa, Y., Ye, M., Araki, M., Matsumoto, S., Liao, J., Hu, L., Sugimoto, T., Ijiri, Y., Takeda, A., Nishiyama, Y., Sato, C., Muraoka, S., Tamura, A., Osoda, T., Tsuda, K., Miyakawa, T., Fukunishi, H., Shimada, J., Kumasaka, T., Yamamoto, M., Kataoka, T.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 110(20) Pages: 8182-8187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590336
[Journal Article] Structure-based drug design of small-molecule Ras inhibitors having anti-tumor activity2013
- Author(s)
  Shima, F., Kataoka, T
- Journal Title
  
  SPring-8 Resear ch Frontiers
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590336
[Journal Article] In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction2013
- Author(s)
  Shima, F., Yoshikawa, Y., Ye, M., Araki, M., Matsumoto, S., Liao, J., Hu, L., Sugimoto, T., Ijiri, Y., Takeda, A., Nishiyama, Y., Sato, C., Muraoka, S., Tamura, A., Osoda, T., Tsuda, K., Miyakawa, T., Fukunishi, H., Shimada, J., Kumasaka, T., Yamamoto, M., and Kataoka, T
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 110 Issue: 20 Pages: 8182-8187
- DOI
  10.1073/pnas.1217730110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390071
[Journal Article] Structure-based drug design of small-molecule Ras inhibitors having anti-tumor activity.2013
- Author(s)
  Shima, F, and Kataoka, T.
- Journal Title
  
  SPring-8 Research Frontiers
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-23590336
[Journal Article] Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants2012
- Author(s)
  Muraoka S, Shima F, Araki M, Inoue T, Yoshimoto A, Ijiri Y, Seki N, Tamura A, Kumasaka T, Yamamoto M, Kataoka T.
- Journal Title
  
  FEBS Lett
  
  Volume: 586 Pages: 1715-1718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590336
[Journal Article] Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants2012
- Author(s)
  村岡真
- Journal Title
  
  FEBS Letters
  
  Volume: 586巻・12号 Issue: 12 Pages: 1715-1718
- DOI
  10.1016/j.febslet.2012.04.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00683, KAKENHI-PROJECT-23390071
[Journal Article] Critical Roles of Interactions Among Switch I-preceding Residues and Between Switch II and Its Neighboring・-helix on Conformational Dynamics of the GTP-bound Ras Family Small GTPases.2011
- Author(s)
  Matsumoto, K., Shima, F., Muraoka, S., Araki, M., Hu, L., Ijiri, Y., Hirai, R., Yoshioka, T., Kumasaka, T., Yamamoto, M., Tamura, A., Kataoka, T.
- Journal Title
  
  J.Biol.Chem. 286(in press.)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590280
[Journal Article] RA-GEF-1 (rapgef2) is essential for proper development of the midline commissures2011
- Author(s)
  Bilasy SE, Satoh T, Terashima T, Kataoka T.
- Journal Title
  
  Neuroscience Research
  
  Volume: 71(3) Issue: 3 Pages: 200-9
- DOI
  10.1016/j.neures.2011.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570202, KAKENHI-PROJECT-23390071
[Journal Article] Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers2011
- Author(s)
  荒木望嗣
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286巻・45号 Issue: 45 Pages: 39644-39653
- DOI
  10.1074/jbc.m111.227074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00683, KAKENHI-PROJECT-23390071
[Journal Article] Critical Roles of Interactions Among Switch I-preceding Residues and Between Switch II and Its Neighboring α-helix on Conformational Dynamics of the GTP-bound Ras Family Small GTPases2011
- Author(s)
  松本耕祐
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286巻・17号 Issue: 17 Pages: 15403-15412
- DOI
  10.1074/jbc.m110.204933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00683, KAKENHI-PROJECT-23390071
[Journal Article] Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring ?-helix on conformational dynamics of the GTP-bound Ras family small GTPases.2011
- Author(s)
  Matsumoto, K., Shima, F., Muraoka, S., Araki, M., Hu, L., Ijiri, Y., Hirai, R., Liao, J., Yoshioka, T., Kumasaka, T., Yamamoto, M., Tamura, A., Kataoka, T.
- Journal Title
  
  J.Biol.Chem. 286
  
  Pages: 15403-15412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Solution Structure of the State 1 Conformer of GTP-bound H-Ras Protein and Distinct Dynamic Properties between the State 1 and State 2 Conformers2011
- Author(s)
  Araki, M., Shima, F., Yoshikawa, Y., Muraoka, S., Ijiri, Y., Nagahara, Y., Shirono, T., Kataoka, T., Tamura A.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 39644-39653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590336
[Journal Article] Structural basis for conformational dynamics of GTP-bound Ras protein.2010
- Author(s)
  Shima, F., Ijiri, Y., Muraoka, S., Liao, J., Ye, M., Araki, M., Matsumoto, K., Yamamoto, N., Sugimoto, T., Yoshikawa, Y., Kumasaka, T., Yamamoto, M., Tamura, A., Kataoka, T.
- Journal Title
  
  J.Biol.Chem. 285
  
  Pages: 22696-22705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Structural basis for conformational dynamics of GTP-bound Ras protein.2010
- Author(s)
  Shima, F., Ijiri, Y., Muraoka, S., Liao, J., Ye, M., Araki, M., Matsumoto, K., Yamamoto, N., Sugimoto, T., Yoshikawa, Y., Kumasaka, T., Yamamoto, M., Tamura, A., Kataoka, T.
- Journal Title
  
  J. Biol. Chem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Structural basis for conformational dynamics of GTP-bound Ras protein2010
- Author(s)
  Fumi Shima, et al.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 285巻・29号 Pages: 22696-22705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Structural basis for conformational dynamics of GTP-bound Ras protein.2010
- Author(s)
  Shima, et al.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 285 Pages: 22696-22705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590280
[Journal Article] Structural basis for conformational dynamics of GTP-bound Ras protein.2010
- Author(s)
  Shima, F., Ijiri, Y., Muraoka, S., Liao, J., Ye, M., Araki, M., Matsumoto, K., Yamamoto, N., Sugimoto, T., Yoshikawa, Y., Kumasaka, T., Yamamoto, M., Tamura, A., Kataoka, T.
- Journal Title
  
  J.Biol.Chem. 285(29)
  
  Pages: 22696-22705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590280
[Journal Article] Dorsal telencephalon- specific RA-GEF-1 knockout mice develop heterotropic cortical mass and commissural fiber defect2009
- Author(s)
  Bilasy, S.E., Satoh, T., Ueda, S., Wei, P., Kanemura, H., Aiba, A., Terashima, T., Kataoka, T.
- Journal Title
  
  Eur. J. Neurosci. 29
  
  Pages: 1994-2008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1.2009
- Author(s)
  Kanemura, H., Satoh, T., Bilasy, S.E., Ueda, S., Hirashima, M., Kataoka, T.
- Journal Title
  
  Biochem. Biophys. Res. Comm. 387
  
  Pages: 754-759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Biochemical characterization of missense mutations in the Arf/Arl-family small GTease Arl6 causing Bardet-Biedl syndrome.2009
- Author(s)
  Kobayashi T, Hori Y, Ueda N, Kajiho H, Muraoka S, Shima F, Kataoka T, Kontani K, Katada T.
- Journal Title
  
  Biochem Biophys Res Commun. 381
  
  Pages: 439-442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20054011
[Journal Article] Biochemical Characterization of Missense Mutations in the Arf/Arl-Family Small GTPase Arl6 Causing Bardet-Biedl Syndrome2009
- Author(s)
  Kobayashi T, Hori Y, Ueda N, Kajiho H, Muraoka S, Shima F, Kataoka T, Kontani K, Katada T.
- Journal Title
  
  Biochem Biophys Res Commun. (In press : 2009 Feb 20. [Epub ahead of print])
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590280
[Journal Article] Biochemical Characterization of Missense Mutations in the Arf/Arl-Family Small GTPase Ari6 Causing Bardet-Biedl Syndrome2009
- Author(s)
  Kobayashi T, Hori Y, Ueda N, Kajiho H, Muraoka S, Shima F, Kataoka T, Kontani K, Katada T
- Journal Title
  
  Biochem Biophys Res Commun (In press)(Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20054011
[Journal Article] Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome.2009
- Author(s)
  Kobayashi T, Hori Y, Ueda N, Kajiho H, Muraoka S, Shima F, Kataoka T, Kontani K, Katada T
- Journal Title
  
  Biochem Biophys Res Commun. 381
  
  Pages: 439-442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590280
[Journal Article] Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome.2009
- Author(s)
  Kobayashi, T., Hori, Y., Ueda, N., Kajiho, H., Muraoka, S., Shima, F., Kataoka, T., Kontani, K., Katada, T.
- Journal Title
  
  Biochem Biophys Res Commun. 381(3)
  
  Pages: 439-442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590280
[Journal Article] Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotropic cortical mass and commissural fiber defect.2009
- Author(s)
  Bilasy, S. E., Satoh, T., Ueda, S., Wei, P., Kanemura, H., Aiba, A., Terashima, T., Kataoka, T.
- Journal Title
  
  Eur.J.Neurosci. 29
  
  Pages: 1994-2008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1.2009
- Author(s)
  Kanemura, H., Satoh, T., Bilasy, S.E., Ueda, S., Hirashima, M., Kataoka, T.
- Journal Title
  
  Biochem.Biophys.Res.Comm. 387
  
  Pages: 754-759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics.2008
- Author(s)
  Liao, J., Shima, F., Araki, M., Ye, M., Muraoka, S., Sugimoto, T., Kawamura, M., Yamamoto, N., Tamura, A., Kataoka, T.
- Journal Title
  
  Biochem.Biophys.Res.Comm. 369
  
  Pages: 327-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390080
[Journal Article] Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics.2008
- Author(s)
  Liao, J., Shima, F., Araki, M., Ye, M., Muraoka, S., Sugimoto, T., Kawamura, M., Yamamoto, N., Tamura, A., Kataoka, T.
- Journal Title
  
  Biochem. Biophys. Res. Comm. 369
  
  Pages: 327-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1.2007
- Author(s)
  Wei, P., Satoh, T., Edamatsu, H., Aiba, A., Setsu, T., Terashima, T., Kitazawa, S., Nakao, K., Yoshikawa, Y., Tamada, M., Kataoka, T.
- Journal Title
  
  Biochem. Biophys. Res. Comm. 363
  
  Pages: 106-112
- NAID
  120004107908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases.2005
- Author(s)
  Ye, M., Shima, F., Muraoka, S., Liao, J., Okamoto, H., Yamamoto, M., Tamura, A., Yagi, N., Ueki, T., Kataoka, T.
- Journal Title
  
  J. Biol. Chem. 280
  
  Pages: 31267-31275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] エフェクター活性化過程に必須であるRasの翻訳後修飾2005
- Author(s)
  島扶美, et al.
- Journal Title
  
  生化学 77巻・6号
  
  Pages: 519-526
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Posttranslational modifications of Ras essential for activation of its effectors2005
- Author(s)
  Fumi Shima et al.
- Journal Title
  
  Seikagaku 77 (6)
  
  Pages: 519-526
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390078
[Journal Article] エフェクター活性化過程に必須であるRasの翻訳後修飾2005
- Author(s)
  島扶美, et al.
- Journal Title
  
  生化学 77巻・6号
  
  Pages: 519-526
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390078
[Journal Article] エフェクターの活性化過程に必須であるRasの翻訳後修飾2005
- Author(s)
  島芙美
- Journal Title
  
  「生化学」特集号 77巻・6号(未定)
- Data Source
  KAKENHI-PROJECT-16790169
[Journal Article] Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C・2005
- Author(s)
  Tadano, M., Edamatsu, H., Minamisawa, S., Yokoyama, U., Ishikawa, Y., Suzuki, N., Wu, D., Masago-Toda, M., Yamawaki-Kataoka, Y., Setsu, T., Terashima, T., Maeda, S., Satoh, T., Kataoka, T.
- Journal Title
  
  Mol. Cell. Biol. 25
  
  Pages: 2191-2199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] エフェクター活性化過程に必須であるRasの翻訳後修飾-Ras-エフェクター相互作用の高次構造解析2005
- Author(s)
  島扶美、片岡徹
- Journal Title
  
  生化学 77
  
  Pages: 519-526
- NAID
  10016452222
- Data Source
  KAKENHI-PROJECT-17014061
[Journal Article] Posttranslational modifications of Ras essential for activation of its effectors.
- Author(s)
  Fumi Shima et al.
- Journal Title
  
  Seikagaku (未定)(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390093
[Journal Article] Posttranslational modifications of Ras essential for activation of its effectors.
- Author(s)
  Fumi Shima et al.
- Journal Title
  
  Seikagaku (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390093
[Patent] Ras機能阻害剤のスクリーニング方法2012
- Inventor(s)
  片岡徹、島扶美、田村厚夫、荒木望嗣
- Industrial Property Rights Holder
  神戸大学
- Filing Date
  2012-01-31
- Overseas
- Data Source
  KAKENHI-PROJECT-23390071
[Patent] 変異型Rasポリペプチドの結晶(MUTANT RAS POLYPEPTYDE CRYSTAL)2012
- Inventor(s)
  片岡徹, 島扶美, 田村厚夫, 熊坂崇
- Industrial Property Rights Holder
  神戸大学, 高輝度光科学研究センター
- Industrial Property Rights Type
  特許
- Filing Date
  2012-01-12
- Data Source
  KAKENHI-PROJECT-23590336
[Patent] Ras部分ポリペプチド含有水溶液及び機能阻害剤のスクリーニング方法(Aqueous Solution Containing Partial Ras Polypeptide and Method For Screening Inhibitor of Ras Function)2012
- Inventor(s)
  片岡徹, 島扶美, 田村厚夫 , 荒木望嗣
- Industrial Property Rights Holder
  神戸大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-01-31
- Data Source
  KAKENHI-PROJECT-23590336
[Patent] Ras機能阻害作用を有するチオキソチアゾリジン誘導体2012
- Inventor(s)
  片岡徹, 島扶美, 閨正博, 笹原大輔
- Industrial Property Rights Holder
  神戸大学, 神戸天然物化学株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2012-05-09
- Data Source
  KAKENHI-PROJECT-23590336
[Patent] Ras機能阻害剤のスクリーニング方法2011
- Inventor(s)
  片岡徹、島扶美、田村厚夫、荒木望嗣
- Industrial Property Rights Holder
  神戸大学
- Industrial Property Number
  2011-023695
- Filing Date
  2011-02-07
- Data Source
  KAKENHI-PROJECT-20590280
[Patent] Ras機能阻害剤のスクリーニング方法2011
- Inventor(s)
  片岡徹、島扶美、田村厚夫、荒木望嗣
- Industrial Property Rights Holder
  神戸大学
- Industrial Property Number
  2011-023695
- Filing Date
  2011-02-07
- Data Source
  KAKENHI-PROJECT-20390080
[Patent] Ras部分ポリペプチド含有水溶液及び機能阻害剤のスクリーニング方法(Aqueous Solution Containing Partial Ras Polypeptide and Method For Screening Inhibitor of Ras Function)2011
- Inventor(s)
  片岡徹, 島扶美, 田村厚夫 , 荒木望嗣
- Industrial Property Rights Holder
  神戸大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2011-023695
- Filing Date
  2011-02-07
- Overseas
- Data Source
  KAKENHI-PROJECT-23590336
[Patent] Ras機能阻害作用を有するチオキソチアゾリジン誘導体2011
- Inventor(s)
  片岡徹, 島扶美, 閨正博, 笹原大輔
- Industrial Property Rights Holder
  神戸大学, 神戸天然物化学株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2011-105613
- Filing Date
  2011-05-10
- Overseas
- Data Source
  KAKENHI-PROJECT-23590336
[Patent] 変異型Rasポリペプチドの結晶2010
- Inventor(s)
  片岡徹、島扶美、田村厚夫、熊坂崇
- Industrial Property Rights Holder
  神戸大学、財団法人高輝度光科学研究センター
- Filing Date
  2010-07-13
- Overseas
- Data Source
  KAKENHI-PROJECT-20390080
[Patent] 変異型Rasポリペプチドの結晶2010
- Inventor(s)
  片岡徹、島扶美、田村厚夫、熊坂崇
- Industrial Property Rights Holder
  神戸大学、高輝度光科学研究センター
- Filing Date
  2010-07-13
- Data Source
  KAKENHI-PROJECT-20390080
[Patent] 変異型Rasポリペプチドの結晶(MUTANT RAS POLYPEPTYDE CRYSTAL)2010
- Inventor(s)
  片岡徹、島扶美、田村厚夫、熊坂崇
- Industrial Property Rights Holder
  国立大学法人神戸大学、財団法人高輝度光科学研究センター
- Filing Date
  2010-07-13
- Data Source
  KAKENHI-PROJECT-20590280
[Patent] 変異型Rasポリペプチドの結晶2009
- Inventor(s)
  片岡徹、島扶美、田村厚夫、熊坂崇
- Industrial Property Rights Holder
  神戸大学、高輝度光科学研究センター
- Industrial Property Number
  2009-165717
- Filing Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-17014061
[Patent] 変異型Rasポリペプチドの結晶(MUTANT RAS POLYPEPTYDE CRYSTAL)2009
- Inventor(s)
  片岡徹, 島扶美, 田村厚夫, 熊坂崇
- Industrial Property Rights Holder
  神戸大学, 高輝度光科学研究センター
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2009-165717
- Filing Date
  2009-07-14
- Overseas
- Data Source
  KAKENHI-PROJECT-23590336
[Patent] 変異型Rasポリペプチドの結晶2009
- Inventor(s)
  片岡徹、島扶美、田村厚夫、熊坂崇
- Industrial Property Rights Holder
  神戸大学、財団法人高輝度光科学研究センター
- Industrial Property Number
  2009-165717
- Filing Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-20590280
[Patent] 変異型Rasポリペプチドの結晶2009
- Inventor(s)
  片岡徹、島扶美、田村厚夫、熊坂崇
- Industrial Property Rights Holder
  神戸大学、財団法人高輝度光科学研究センター
- Industrial Property Number
  2009-165717
- Filing Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-20054011
[Patent] 変異型Rasポリペプチドの結晶2009
- Inventor(s)
  片岡徹、島扶美、田村厚夫、熊坂崇
- Industrial Property Rights Holder
  神戸大学、高輝度光科学研究センター
- Industrial Property Number
  2009-165717
- Filing Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-20390080
[Presentation] 低分子量Gタンパク質H-Rasのフリーズトラップ結晶構造解析によるGTPase活性分子メカニズムの追跡2022
- Author(s)
  河村高志, 槇野義輝, 長谷川和也, 吉川陽子, 島扶美, 熊坂崇
- Organizer
  第95回生化学会大会
- Data Source
  KAKENHI-PUBLICLY-22H04752
[Presentation] SACLA/SPring-8/NMRを駆使した低分子量G蛋白質Rasno不活性化機構におけるアロステリック構造変化の解明2022
- Author(s)
  槇野義輝, 河村高志, 吉川陽子, 南後恵理子, 熊坂崇, 島扶美
- Organizer
  第95回生化学会大会
- Data Source
  KAKENHI-PUBLICLY-22H04752
[Presentation] 低分子量G蛋白質RasのGTP加水分反応過程におけるヌクレオチド近傍の構造変化2021
- Author(s)
  佐伯茉帆, 槇野義輝, 河村高志, 南後恵理子, 熊坂崇, 島扶美
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K06525
[Presentation] 光反応性基質を利用したがん遺伝子産物Rasの酵素触媒反応の可視化2021
- Author(s)
  島扶美, 槇野義輝, 南後恵理子, 熊坂崇
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05444
[Presentation] 低分子量G蛋白質RasのGTP加水分反応過程におけるヌクレオチド近傍の構造変化2021
- Author(s)
  佐伯茉帆, 槇野義輝, 河村高志, 南後恵理子, 熊坂崇, 島扶美
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-20H05444
[Presentation] 光反応性基質を利用したがん遺伝子産物Rasの酵素触媒反応の可視化2021
- Author(s)
  島扶美, 槇野義輝, 南後恵理子, 熊坂崇
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06525
[Presentation] Analysis of conformational dynamics of small G-protein Ras on GTP hydrolysis process by SACLA, SPring-8 and NMR2020
- Author(s)
  Maho Saeki, Yoshiteru Makino, Shigeyuki Matsumoto, Takashi Kawamura, Eriko Nango, Takashi Kumasaka and Fumi Shima
- Organizer
  43回日本分子生物学会
- Data Source
  KAKENHI-PUBLICLY-20H05444
[Presentation] Analysis of conformational dynamics of small G-protein Ras on GTP hydrolysis process by SACLA, SPring-8 and NMR2020
- Author(s)
  Maho Saeki, Yoshiteru Makino, Shigeyuki Matsumoto, Takashi Kawamura, Eriko Nango, Takashi Kumasaka and Fumi Shima
- Organizer
  43回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K06525
[Presentation] 微小結晶を利用したRas caged-GTP時分割測定の試み2020
- Author(s)
  河村　高志, 槇野　義輝*, 長谷川　和也, 中根　崇智, 馬場　清喜, 南後　恵理子, 田中里枝, 岩田想, 島扶美*, 熊坂崇
- Organizer
  第33回日本放射光学会年会・放射光科学合同シンポジウム
- Data Source
  KAKENHI-PROJECT-19K06525
[Presentation] Caged-GTPを用いたがん遺伝子産物RasのSACLA、Spring-8、NMRによるGTP加水分解過程の構造変化の解明2019
- Author(s)
  槇野義輝*、河村高志、松本篤幸、南後恵理子、岩田想、熊坂崇、島扶美*
- Organizer
  第57回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-19K06525
[Presentation] Analysis of the mechani sm underlying the anti-metastatic action of R as inhibitors by using a lung metastatic mod el mouse2013
- Author(s)
  Osamu Takano, Yoko Yoshikawa, Fumi Shima, Tohru Kataoka
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-04
- Data Source
  KAKENHI-PROJECT-23590336
[Presentation] Analysis of the mechanism underlying the anti-metastatic action of Ras inhibitors by using a lung metastatic model mouse.2013
- Author(s)
  Osamu Takano,Yoko Yoshikawa,Fumi Shima,Tohru Kataoka.
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23590336
[Presentation] In silico discovery of novel Ras inhibitors that display anti-tumor activity by blocking the Ras-effector interaction2013
- Author(s)
  Shima F
- Organizer
  WINPTech 2012
- Place of Presentation
  神戸大学統合研究拠点(兵庫県)
- Year and Date
  2013-02-19
- Invited
- Data Source
  KAKENHI-PROJECT-23590336
[Presentation] In silico discovery of novel Ras inhibitors that display anti-tumor activity by blocking the Ras-effector interaction2013
- Author(s)
  Shima, F
- Organizer
  WINPTech 2012 : Recent Development in Drug Discovery Sciences
- Place of Presentation
  神戸大学統合拠点
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] In silico discovery of novel Ras inhibitors that display anti-tumor activity by blocking the Ras-effector interaction2013
- Author(s)
  Fumi Shima
- Organizer
  WINPTech 2012: Recent Development in Drug Discovery Sciences
- Place of Presentation
  神戸大学統合拠点(神戸市)
- Invited
- Data Source
  KAKENHI-PROJECT-23390071
[Presentation] In silico discovery of novel Ras inhibitors that display anti-tumor activity by blocking the Ras-effector interaction2013
- Author(s)
  Fumi Shima
- Organizer
  Workshop on Innovation and Pioneering Technology 2012
- Place of Presentation
  Intergraded Research Center of Kobe University
- Invited
- Data Source
  KAKENHI-PROJECT-23590336
[Presentation] Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers2012
- Author(s)
  Araki M, Shima F, Yoshikawa Y, Muraoka S, Ijiri Y, Nagahara Y, Shirono T, Tamura A, Kataoka T
- Organizer
  Biophysical Society 56^<th> Annual Meeting
- Place of Presentation
  Pos-L1 SAN DIEGO, CALIFORNIA, USA(ポスター)
- Data Source
  KAKENHI-PROJECT-23590336
[Presentation] New strategy for development of anti-cancer drugs targeting the ras oncogene products.2011
- Author(s)
  片岡徹、島扶美
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪府)(招待講演)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-20590280
[Presentation] 大脳皮質の交連線維形成におけるグアニンヌクレオチド交換因子RA-GEF-1の機能2011
- Author(s)
  寺島俊雄, ら
- Organizer
  第88回日本生理学会・第116回日本解剖学会合同大会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-20390080
[Presentation] New strategy for development of anti-cancer drugs targeting the ras oncogene products(指定演題・モーニングレクチャー)2010
- Author(s)
  片岡徹、島扶美
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590280
[Presentation] Molecular mechanism of conformational transition of GTP-bound Ras revealed by the crystal structure analysis of M-Ras mutants2010
- Author(s)
  松本耕祐、島扶美、村岡真、井尻悠一、市川晋也、荒木望嗣、熊坂崇、田村厚夫、片岡徹
- Organizer
  BMB2010(第33回日本分子生物学会年回・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590280
[Presentation] GTP結合型Rasの構造遷移における分子メカニズムの解析2009
- Author(s)
  井尻悠一, 島扶美, 村岡真, 廖静伶, 松本耕祐, 荒木望嗣, 熊坂崇, 田村厚夫, 片岡徹
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20590280
[Presentation] Structural analysis of the novel state1 conformation of Ras protein(ポスター発表)2009
- Author(s)
  松本耕祐, 島扶美, 村岡真, 廖静伶, 井尻悠一, 片岡徹
- Organizer
  膜生物学グローバルCOE第3回ワークショップ
- Place of Presentation
  兵庫県・淡路
- Data Source
  KAKENHI-PROJECT-20590280
[Presentation] 出芽酵母の低分子量Gタンパク質Ras2のX線結晶構造解析2009
- Author(s)
  村岡真, 島扶美, 廖静伶, 片岡徹
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20054011
[Presentation] GTP結合型Rasの構造遷移における分子メカニズムの解析(ポスター発表)2009
- Author(s)
  井尻悠一、島扶美、村岡真、廖静伶、松本耕祐、荒木望嗣、熊坂崇、田村厚夫、片岡徹
- Organizer
  第32回日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590280
[Presentation] 出芽酵母の低分子量Gタンパク質Ras2のX線結晶構造解析2009
- Author(s)
  村岡真, 島扶美, 廖静伶, 片岡徹
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20590280
[Presentation] GTP結合型Rasの構造遷移における分子メカニズムの解析2009
- Author(s)
  井尻悠一, 島扶美, 村岡真, 彦静伶, 松本耕祐, 荒木望嗣, 熊坂崇, 田村厚夫, 片岡徹
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20054011
[Presentation] 背側終脳特異的RA-GEF-1ノックアウトマウスは大脳皮質ヘテロトピアと交連線維系の欠損を示す2009
- Author(s)
  寺島俊雄, ら
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20390080
[Presentation] 出芽酵母の低分子量Gタンパク質Ras2のX線結晶構造解析(ポスター発表)2009
- Author(s)
  村岡真、島扶美、廖静伶、片岡徹
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590280
[Presentation] New strategy to develop Ras specific inhibitors based on conformational equilibriumof Ras oncoprotein(ポスター発表)2008
- Author(s)
  Kousuke Matsumoto, Fumi Shima, Jingling Liao, Shin Muraoka, Tomoko Inoue, Min Ye, Takeshi Sugimoto, Yoko Yoshikawa, Moto Hiramatsu, Tohru Kataoka
- Organizer
  第3回グローバルCOE研究討論会兼グローバルCOE第2回ワークショップ
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590280
[Presentation] New strategy to develop Ras specific inhibitors(ポスター発表)2008
- Author(s)
  Moto Hiramatsu, Fumi Shima, Yoko Yoshikawa, Shin Muraoka, Satomi Kaizawa, Min Ye, Takeshi Sugimoto, Jingling Liao, Kousuke Matsumoto, Tohru Kataoka,
- Organizer
  第3回グローバルCOE研究討論会兼グローバルCOE第2回ワークショップ
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590280
[Presentation] GTP結合型H-Rasの高次構造多型性とエフェクターの新規認識機構(ポスター発表)2008
- Author(s)
  関伸章、村岡真、荒木望嗣、吉本梓希子、島扶美、田村厚夫, 片岡徹
- Organizer
  BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590280

1. KATAOKA Tohru (40144472)

# of Collaborated Projects: 9 results

# of Collaborated Products: 22 results
2. EDAMATSU Hironori (70335438)

# of Collaborated Projects: 8 results

# of Collaborated Products: 2 results
3. SATOH Takaya (20251655)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
4. KUMASAKA Takashi (30291066)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. 松本篤幸 (00753906)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. HIRASHIMA Masanori (40383757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. TAMURA Atsuo (90273797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. KITAHARA Ryou (70512284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 苅谷研一 (40263371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 田中成典 (10379480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 寺島俊雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shima Fumi 島 扶美

SHIMA Fumi 島 扶美

Research Projects

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Co-Researchers

Elucidation of cancer signal transduction mechanism using photo-controllable Ras on an atomic scalePrincipal Investigator

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Time-resolved structural analysis of small GTPase Ras signaling transduction by utilizing caged-GTP-coupled Ras proteinPrincipal Investigator

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Atomic-scale dynamic structural analysis of Ras by SACLA, which provide promising information on designing cancer therapeutic agentsPrincipal Investigator

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Research on the molecular basis of conformational dynamics of oncogene product Ras for application to the development of its specific inhibitorsPrincipal Investigator

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Development of anti-cancer drugs having Ras-Raf-binding inhibitory activityPrincipal Investigator

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低分子量G蛋白質の高次構造多型性のシグナル伝達における意義Principal Investigator

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Anti-cancer drug design targeting a novel tertiary structure of ras oncogene productPrincipal Investigator

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低分子量G蛋白質の高次構造多型性のシグナル伝達における意義Principal Investigator

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Ras/Rap結合(RA)ドメインによるGTP結合蛋白質認識機構の解明Principal Investigator

Principal Investigator

Shima Fumi 島扶美

SHIMA Fumi 島扶美

[Journal Article] Molecular Mechanism for Conformational Dynamics of Ras·GTP Elucidated from In-Situ Structural Transition in Crystal.2016