YAMAKAWA Norio 山川哲生

Researcher Number	60335825
Affiliation (based on the past Project Information) *help	2007 – 2009: University of Miyazaki, 医学部, 助教
Review Section/Research Field	Principal Investigator Hematology Except Principal Investigator Hematology / Pathological medical chemistry / Biological Sciences
Keywords	Principal Investigator Evil / Evi1 / 白血病 / アセチル化 Except Principal Investigator Integrin / 転写因子 / EVI1 / 接着存性薬剤耐性(CAM-DR) / Laminin / Zinc finger protein … More / 接着依存性薬剤耐性(CAM-DR) / ZEB1 / TCF8 / IgSF4 / CADM1 / TSLC1 / TCF8/ZEB1 / 成人T細胞白血病 / ゲノム / 遺伝子 / 癌 / BCL11B / 成人T細胞白血病(ATL) / NDRG2 / TCF8(ZEB1) / TSLC1/CADM1/IgSF4 / EVIl / アセチル化修飾 / 接着因子 / がん幹細胞 / GATA-2 / ITGB4 / ITGA6 Less

Molecular analysis of leukemogenesis of adult-T cell leukemia by genomic abnormalities
- Principal Investigator
  
  MORISHITA Kazuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Miyazaki
細胞接着能を標的としたEVI1高発現白血病治療法の開発
- Principal Investigator
  
  森下和広
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  University of Miyazaki
Evi1遺伝子群による細胞接着を介した白血病幹細胞維持機構の解明
- Principal Investigator
  
  MORISHITA Kazuhiro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Miyazaki
elucidation of EVI1 acetylation mechanism and the application to treatment of leukemiaPrincipal Investigator
- Principal Investigator
  
  YAMAKAWA Norio
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  University of Miyazaki

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Patent

[Journal Article] The Increased Expression of Integrinα6(ITGA6) Enhances Drug Resistance in EVI1 Leukemia2012
- Author(s)
  Yamakawa N, Kaneda K, Saito Y, Ichihara E, Morishita K
- Journal Title
  
  PLoS One
  
  Volume: 7(1) Issue: 1 Pages: e30706-e30706
- DOI
  10.1371/journal.pone.0030706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098
[Journal Article] Angiopoietin1 contributes to the maintenance of cell quiescence in EVI1 high leukemia cells2011
- Author(s)
  Ichihara E, Kaneda K, Saito Y, Yamakawa N, Morishita K
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 416 Pages: 239-45
- URL
  http://dx.doi.org/10.1016/j.bbrc.2011.10.061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098
[Journal Article] CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression2011
- Author(s)
  Saito Y, Nakahata S, Yamakawa N, Kaneda K, Ichihara A, Suekane A, and Morishita K
- Journal Title
  
  Leukemia
  
  Volume: 25 Issue: 6 Pages: 921-931
- DOI
  10.1038/leu.2011.36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098, KAKENHI-PUBLICLY-23118523
[Journal Article] Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation2011
- Author(s)
  Nishikata I, Nakahata S, Saito Y, Kaneda K, Ichihara E, Yamakawa N, and Morishita K
- Journal Title
  
  Oncogene
  
  Volume: 30 Issue: 40 Pages: 196-207
- DOI
  10.1038/onc.2011.132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098, KAKENHI-PUBLICLY-23118523
[Journal Article] Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA22010
- Author(s)
  Shimahara A, Yamakawa N, Nishikata I, Morishita K
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Issue: 22 Pages: 16967-16977
- DOI
  10.1074/jbc.m110.102046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390098
[Patent] 細胞接着阻害剤およびその用途2009
- Inventor(s)
  森下和広、山川哲生
- Industrial Property Rights Holder
  宮崎大学
- Industrial Property Number
  2009-041204
- Filing Date
  2009-02-04
- Data Source
  KAKENHI-PROJECT-21659241
[Patent] 細胞接着阻害剤およびその用途2009
- Inventor(s)
  山川哲生, 森下和広
- Industrial Property Rights Holder
  宮崎大学TLO
- Industrial Property Number
  2009-041204
- Filing Date
  2009-02-24
- Data Source
  KAKENHI-PROJECT-20012043
[Patent] 細胞接着阻害剤およびその用途2009
- Inventor(s)
  森下和広、山川哲生
- Industrial Property Rights Holder
  宮崎大学
- Industrial Property Number
  2009-041204
- Filing Date
  2009-02-04
- Data Source
  KAKENHI-PROJECT-20012043
[Patent] 細胞接着阻害剤及びその用途2009
- Inventor(s)
  森下和広、山川哲生
- Industrial Property Rights Holder
  国立大学法人宮崎大学
- Industrial Property Number
  2009-041204
- Filing Date
  2009-02-24
- Data Source
  KAKENHI-PROJECT-19790670
[Patent] 細胞接着阻害剤およびその用途2009
- Inventor(s)
  山川哲生
- Industrial Property Rights Holder
  宮崎大学
- Industrial Property Number
  2009-041204
- Filing Date
  2009-02-24
- Data Source
  KAKENHI-PROJECT-19790670
[Patent] 物質を細胞内へ導入するために用いるエマルション及びそれを用いた物質導入方法2007
- Inventor(s)
  清水正高、西片奈保子、森下和広、山川哲生、酒井美穂
- Industrial Property Rights Holder
  国立大学法人宮崎大学、宮崎県、科学技術振興機構
- Industrial Property Number
  2007-093469
- Filing Date
  2007-03-30
- Data Source
  KAKENHI-PROJECT-19790670
[Presentation] Evi1高発現白血病におけるITGA6/B4依存性細胞接着2009
- Author(s)
  山川哲生
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-19790670
[Presentation] Evi1による細胞接着機構2009
- Author(s)
  山川哲生, 齋藤祐介, 森下和広
- Organizer
  日本分子生物学会第9回春季シンポジウム
- Place of Presentation
  宮崎市
- Year and Date
  2009-05-11
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] 、Evi1による細胞接着機構の解明2009
- Author(s)
  山川哲生
- Organizer
  平成21年度造血器腫瘍研究会
- Place of Presentation
  東京大学
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-19790670
[Presentation] Evi1による細胞接着機構の解明2009
- Author(s)
  山川哲生
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-19790670
[Presentation] Evi1高発現白血病におけるITGA6/B4依存性細胞接着2009
- Author(s)
  山川哲生
- Organizer
  第32回日本分子生物学会年会.
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20012043
[Presentation] Evi1による細胞接着機構の解明2009
- Author(s)
  山川哲生
- Organizer
  平成21年度造血器腫瘍研究会
- Place of Presentation
  東京大学付属病院
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-19790670
[Presentation] ITGA6/ITGB4 dependent-cell adhesion ability in EIV1(+) leukemia2009
- Author(s)
  Yamakawa, N., Saito, Y., and Morishita, K
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜市
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] Evi 1による細胞接着機構2009
- Author(s)
  山川哲生
- Organizer
  日本分子生物学会第9回春季シンポジウム
- Place of Presentation
  シーガイヤワールドコンベンションセンター(宮崎市)
- Year and Date
  2009-05-11
- Data Source
  KAKENHI-PROJECT-20012043
[Presentation] Evi1による細胞接着機構2009
- Author(s)
  山川哲生
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際会議場(神戸市)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20012043
[Presentation] :Evi1 高発現白血病におけるITGA6/B4依存性細胞接着2009
- Author(s)
  山川哲生
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21659241
[Presentation] Evi1 による細胞接着機構2009
- Author(s)
  山川哲生
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際会議場(神戸市)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21659241
[Presentation] 急性骨髄性白血病の原因遺伝子EVI 1によるGATA-2転写活性化の機能解析2009
- Author(s)
  島原明子, 山川哲生, 齋藤祐介, 西片一朗, 森下和広
- Organizer
  日本分子生物学会第9回春季シンポジウム
- Place of Presentation
  宮崎市
- Year and Date
  2009-05-11
- Data Source
  KAKENHI-PROJECT-21390098
[Presentation] Evi1による細胞接着機構について2009
- Author(s)
  山川哲生
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-19790670
[Presentation] EVI1によるGATA-2転写活化にはPCAFによるCtBP結合領域のリジンアセチル化が必要である2008
- Author(s)
  島原明子, 山川哲生, 西片一朗, 森下和広
- Organizer
  第31回日分子生物学云云・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸市
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20012043
[Presentation] EVI1によるGATA転写にはPCAFによるCtBP結合領域のリジンアセチル化が必須である2008
- Author(s)
  島原明子, 山川哲生, 西片一朗, 森下和広
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都市
- Year and Date
  2008-10-12
- Data Source
  KAKENHI-PROJECT-20012043
[Presentation] Evi1による細胞接着機構2008
- Author(s)
  山川哲生
- Organizer
  平成20年度造血器腫瘍研究会
- Place of Presentation
  東京大学
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-19790670
[Presentation] Crucial lysine-acetylation in CtBP binding domain of EVI1 by P/CAF during GATA-2 transcriptional activation2008
- Author(s)
  島原明子, 山川哲生, 西片一朗, 森下和広
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20012043
[Presentation] 白血病細胞でのEvi1の特異的なアセチル化部位の固定2007
- Author(s)
  山川哲生
- Organizer
  平成19年度造血器腫瘍研究会
- Place of Presentation
  国立がんセンター研究所
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-19790670
[Presentation] 白血病細胞でのevi1の特異的なアセチル化部位の同定
- Author(s)
  山川哲生
- Organizer
  平成19年度造血器腫瘍研究会
- Place of Presentation
  国立がんセンター
- Data Source
  KAKENHI-PROJECT-19790670

1. MORISHITA Kazuhiro (80260321)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. NAKAHATA Shingo (80437938)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. NISHIKATA Ichiro (50253844)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. TANIWAKI Masafumi (80163640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 中尾和貴 (20217657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 森下和弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 11 results

YAMAKAWA Norio 山川 哲生

Research Projects

Research Products

Co-Researchers

Molecular analysis of leukemogenesis of adult-T cell leukemia by genomic abnormalities

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞接着能を標的としたEVI1高発現白血病治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evi1遺伝子群による細胞接着を介した白血病幹細胞維持機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

elucidation of EVI1 acetylation mechanism and the application to treatment of leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The Increased Expression of Integrinα6(ITGA6) Enhances Drug Resistance in EVI1 Leukemia2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Angiopoietin1 contributes to the maintenance of cell quiescence in EVI1 high leukemia cells2011

Author(s)

Journal Title

URL

Data Source

[Journal Article] CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA22010

Author(s)

Journal Title

DOI

Data Source

[Patent] 細胞接着阻害剤およびその用途2009

Inventor(s)

Industrial Property Rights Holder

Industrial Property Number

Filing Date

Data Source

[Patent] 細胞接着阻害剤およびその用途2009

Inventor(s)

Industrial Property Rights Holder

Industrial Property Number

Filing Date

Data Source

[Patent] 細胞接着阻害剤およびその用途2009

Inventor(s)

Industrial Property Rights Holder

Industrial Property Number

Filing Date

Data Source

[Patent] 細胞接着阻害剤及びその用途2009

Inventor(s)

Industrial Property Rights Holder

Industrial Property Number

Filing Date

Data Source

[Patent] 細胞接着阻害剤およびその用途2009

Inventor(s)

Industrial Property Rights Holder

YAMAKAWA Norio 山川哲生