TAKA HIKARI 高ひかり

… Alternative Names

高ひかりタカヒカリ

TAKA Hikari 高ひかり

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Researcher Number	60338374
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 助教 2013 – 2020: 順天堂大学, 医学(系)研究科(研究院), 助教 2008: 順天堂大学大学院, 医学研究科, 助教 2007 – 2008: 順天堂大学, 医学部, 助教 2006: 順天堂大学, 大学院医学研究科, 助手 2004 – 2005: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Applied health science / Tumor diagnostics Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pathological medical chemistry / Cerebral neurosurgery / Sports science
Keywords	Principal Investigator 質量分析 / メタボリック症候群 / 体質と環境 / 非感染性慢性疾患 / 低出生体重 / 先制医療 / 発症前診断 / 低出生体重児 / 高脂肪食 / 低体重児 … More / キャピラリー電気泳動質量分析 / DOHaD仮説 / 2型糖尿病 / 生活習慣病 / 膀胱がんの早期発見・診断 / 糖鎖修飾ペプチド / 早期発見・診断 / ストレプトアビジンーフィコエリスリン / 糖鎖修飾ペプチド抗体 / 膀胱癌 / 糖タンパク質抗体 / 膀胱がん / ELISA / ウエスタンブロット / 糖タンパク質 / 尿中腫瘍マーカー … More Except Principal Investigator 質量分析 / LRG / ELISA / 非感染性慢性疾患 / メタボロミクス / NCDｓ / 血中代謝物 / 非感染性慢性疾患（NCDs） / DOHaD / メチルドナー / 胎生期低栄養 / 脂質代謝 / 血清メタボローム / 耐糖能異常 / 血中メタボローム解析 / メチルドナー補充 / 低出生体重 / 胎生期低糖質カロリー制限 / 遺伝性疾患 / 腫瘍 / Bcat1遺伝子 / Tsc2遺伝子 / Tsc1遺伝子 / Bcat1 / mTORC1 / エピゲノム修飾 / Tsc1/2 / アミノ酸代謝 / モデル動物 / 家族性腫瘍 / 動物モデル / 腫瘍細胞 / ES細胞 / 分岐鎖アミノ酸 / 代謝 / エピゲノム / 遺伝性難病 / 結節性硬化症 / proteome analysis / cerebrospinal fluid / idiopathic normal pressure hydrocephalus / leucine-rich alpha-2-glycoprotein / 2D-PAGE / LRG1 / プロテオーム解析 / 髄液 / 特発性正常圧水頭症 / 活性窒素 / 酸化修飾 / プロテオーム / 自然発症高血圧ラット / 自発運動トレーニング / ニトロ化ストレス / 運動 / ラット / プロテオミクス / 一酸化窒素 / 活性酸素 Less

体質と環境のミスマッチから生じる非感染性慢性疾患(NCDs)発症リスクの機構解明Principal Investigator
- Principal Investigator
  
  高ひかり
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Juntendo University
Metabolomics reveals risk factors for the development of diseases in low-birth weight infants for preemptive medicine
- Principal Investigator
  
  Kaga Naoko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Juntendo University
Metabolic changes and epigenetic abnormalities caused by tuberous sclerosis compex (TSC) gene mutation
- Principal Investigator
  
  Kobayashi Toshiyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Juntendo University
Realization of Preemptive Medicine by elucidating the onset mechanism of diabetes attributed to mismatch between Constitution and EnvironmentPrincipal Investigator
- Principal Investigator
  
  TAKA HIKARI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Juntendo University
Search for new urothelial cancer biomarkersPrincipal Investigator
- Principal Investigator
  
  TAKA HIKARI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Juntendo University
Proteomics analysis of the modified proteins in rat by reactive oxygen and reactive nitrogen species generated with exercise
- Principal Investigator
  
  FUMIYUKI Yamakura
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Sports science
- Research Institution
  Juntendo University
Proteome analysis of cerebrospinal fluid proteins in idiopathic normal pressure hydrocephalus.
- Principal Investigator
  
  MIYAJIMA Masakazu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  JUNTENDO UNIVERSITY

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2007 2006 Other

All Journal Article Presentation Book

[Book] 腎臓病実験法ハンドブック2013
- Author(s)
  富野　康日己、藤村　務、高　ひかり、他
- Total Pages
  238
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-25430140
[Book] "Formation of 6-Nitrotryptophan in purified proteins by reactive nitrogen species : a possible new biomarker" in International Congress Series 13042007
- Author(s)
  Yamakura F, Ikeda, I Matsumoto T, Taka H, Kaga N
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-18500514
[Book] "Proteomic analysis of 6-nitrotryptophan containing proteins in peroxynitrite-treated pc12 cells" in International Congress Series 13042007
- Author(s)
  Ikeda K, Iwai H, Matsumoto T, Mineki R, Taka, H Takamori K Ogawa H, and Yamakura F
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-18500514
[Journal Article] The fluid factor OVGP1 provides a significant oviductal microenvironment for the reproductive process in golden hamster2023
- Author(s)
  Yamatoya Kenji、Kurosawa Masaru、Hirose Michiko、Miura Yoshiki、Taka Hikari、Nakano Tomoyuki、Hasegawa Akiko、Kagami Kyosuke、Yoshitake Hiroshi、Goto Kaoru、Ueno Takashi、Fujiwara Hiroshi、Shinkai Yoichi、Kan Frederick W K、Ogura Atsuo、Araki Yoshihiko
- Journal Title
  
  Biology of Reproduction
  
  Volume: 110 Issue: 3 Pages: 465-475
- DOI
  10.1093/biolre/ioad159
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-20K07834, KAKENHI-PROJECT-22K09648, KAKENHI-PROJECT-21K09503, KAKENHI-PROJECT-18KK0256, KAKENHI-PLANNED-19H05758, KAKENHI-PROJECT-23K27096
[Journal Article] Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex2023
- Author(s)
  Kurusu Reo、Fujimoto Yuki、Morishita Hideaki、Noshiro Daisuke、Takada Shuhei、Yamano Koji、Tanaka Hideaki、Arai Ritsuko、Kageyama Shun、Funakoshi Tomoko、Komatsu-Hirota Satoko、Taka Hikari、Kazuno Saiko、Miura Yoshiki、Koike Masato、Wakai Toshifumi、Waguri Satoshi、Noda Nobuo N.、Komatsu Masaaki
- Journal Title
  
  Developmental Cell
  
  Volume: － Issue: 13 Pages: 1189-1205
- DOI
  10.1016/j.devcel.2023.04.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K23841, KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-22K06300, KAKENHI-PROJECT-23K05683, KAKENHI-PROJECT-23K06323, KAKENHI-ORGANIZER-19H05705, KAKENHI-PLANNED-19H05706, KAKENHI-PLANNED-19H05707, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-21H02998, KAKENHI-PROJECT-23K27134, KAKENHI-PROJECT-23K27351, KAKENHI-PROJECT-23H05327
[Journal Article] Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice2023
- Author(s)
  Kakehi Saori、Tamura Yoshifumi、Ikeda Shin-ichi、Kaga Naoko、Taka Hikari、Nishida Yuya、Kawamori Ryuzo、Watada Hirotaka
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 14
- DOI
  10.3389/fphys.2023.1198390
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-21K11684
[Journal Article] The Effect of Long-Term Inorganic Iodine on Intrathyroidal Iodothyronine Content and Gene Expression in Mice with Graves' Hyperthyroidism2023
- Author(s)
  Uchida Toyoyoshi、Shimamura Mika、Taka Hikari、Kaga Naoko、Miura Yoshiki、Nishida Yuya、Nagayama Yuji、Watada Hirotaka
- Journal Title
  
  Thyroid
  
  Volume: 33 Issue: 3 Pages: 330-337
- DOI
  10.1089/thy.2022.0496
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-19K11752
[Journal Article] Biochemical characterization of mitochondria from adult worms and plerocercoid larvae of Spirometra mansoni shows mixed populations of anaerobic and aerobic mitochondria2023
- Author(s)
  Takamiya Shinzaburo、Nakamura Takeshi、Tsubokawa Daigo、Tsuji Naotoshi、Fukuda Koichi、Yamasaki Hiroshi、Fujimura Tsutomu、Taka Hikari、Kaga Naoko、Kobayashi-Tanabe Momoko、Matsuda Motoo、Mita Toshihiro
- Journal Title
  
  Parasitology International
  
  Volume: 92 Pages: 102695-102695
- DOI
  10.1016/j.parint.2022.102695
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-21K06996, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-20K05880
[Journal Article] A Comprehensive Analysis of Plasma Cytokines and Metabolites Shows an Association between Galectin-9 and Changes in Peripheral Lymphocyte Subset Percentages Following Coix Seed Consumption2022
- Author(s)
  Suzuki Yoshio、Miyahara Taisei、Jinnouchi Minami、Miura Yoshiki、Taka Hikari、Kaga Naoko、Ohara-Takada Akiko
- Journal Title
  
  Nutrients
  
  Volume: 14 Issue: 9 Pages: 1696-1696
- DOI
  10.3390/nu14091696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-18K07829
[Journal Article] Short-term physical inactivity induces diacylglycerol accumulation and insulin resistance in muscle via lipin1 activation2021
- Author(s)
  Kakehi Saori、Tamura Yoshifumi、Ikeda Shin-ichi、Kaga Naoko、Taka Hikari、Ueno Noriko、Shiuchi Tetsuya、Kubota Atsushi、Sakuraba Keishoku、Kawamori Ryuzo、Watada Hirotaka
- Journal Title
  
  American Journal of Physiology-Endocrinology and Metabolism
  
  Volume: 321 Issue: 6 Pages: E766-E781
- DOI
  10.1152/ajpendo.00254.2020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09403, KAKENHI-PROJECT-18H03152, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-20K09834, KAKENHI-PROJECT-21K06496, KAKENHI-PROJECT-21K11684, KAKENHI-PROJECT-18K19745
[Journal Article] Nicotine Oral Administration Attenuates DSS-Induced Colitis Through Upregulation of Indole in the Distal Colon and Rectum in Mice2021
- Author(s)
  Nakajima Akihito、Shibuya Tomoyoshi、Sasaki Takashi、Lu Yu Jie、Ishikawa Dai、Haga Keiichi、Takahashi Masahito、Kaga Naoko、Osada Taro、Sato Nobuhiro、Nagahara Akihito
- Journal Title
  
  Frontiers in Medicine
  
  Volume: 8
- DOI
  10.3389/fmed.2021.789037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08657, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-21K08692
[Journal Article] Alterations of the gut ecological and functional microenvironment in different stages of multiple sclerosis2020
- Author(s)
  Takewaki D, Suda W, Sato W, Takayasu L, Kumar N, Kimura K, Kaga N, Mizuno T, Miyake S, Hattori M, Yamamura T
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 117 Issue: 36 Pages: 22402-22412
- DOI
  10.1073/pnas.2011703117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-18H04045
[Journal Article] Correction: Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-12019
- Author(s)
  Sekihara Kazumasa、Saitoh Kaori、Han Lina、Ciurea Stefan、Yamamoto Shinichi、Kikkawa Mika、Kazuno Saiko、Taka Hikari、Kaga Naoko、Arai Hajime、Miida Takashi、Andreeff Michael、Konopleva Marina、Tabe Yoko
- Journal Title
  
  Oncotarget
  
  Volume: 10 Issue: 63 Pages: 6842-6842
- DOI
  10.18632/oncotarget.27309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-19K11752
[Journal Article] A metabolic profile of polyamines in parkinson disease: A promising biomarker2019
- Author(s)
  Saiki Shinji、Sasazawa Yukiko、Fujimaki Motoki、Kamagata Koji、Kaga Naoko、Taka Hikari、Li Yuanzhe、Souma Sanae、Hatano Taku、Imamichi Yoko、Furuya Norihiko、Mori Akio、Oji Yutaka、Ueno Shin‐Ichi、Nojiri Shuko、Miura Yoshiki、Ueno Takashi、Funayama Manabu、Aoki Shigeki、Hattori Nobutaka
- Journal Title
  
  Annals of Neurology
  
  Volume: 86 Issue: 2 Pages: 251-263
- DOI
  10.1002/ana.25516
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0027, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18H02744, KAKENHI-PROJECT-18K15464
[Journal Article] Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine.2018
- Author(s)
  Tabe Y, Saitoh K, Yang H, Sekihara K, Yamatani K, Ruvolo V, Taka H, Kaga N, Kikkawa M, Arai H, Miida T, Andreeff M, Spagnuolo PA, Konopleva M.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 16837-16837
- DOI
  10.1038/s41598-018-35198-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07424, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-16K19855, KAKENHI-PROJECT-15K08653, KAKENHI-PROJECT-16K01834
[Journal Article] Choline-related metabolites influenced by feeding patterns in preterm and term infants2018
- Author(s)
  Shoji Hiromichi、Taka Hikari、Kaga Naoko、Ikeda Naho、Hisata Ken、Miura Yoshiki、Shimizu Toshiaki
- Journal Title
  
  The Journal of Maternal-Fetal & Neonatal Medicine
  
  Volume: ー Issue: 2 Pages: 1-6
- DOI
  10.1080/14767058.2018.1488165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-20K08194, KAKENHI-PROJECT-17K10192
[Journal Article] Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease.2018
- Author(s)
  Fujimaki M, Saiki S, Li Y, Kaga N, Taka H, Hatano T, Ishikawa KI, Oji Y, Mori A, Okuzumi A, Koinuma T, Ueno SI, Imamichi Y, Ueno T, Miura Y, Funayama M, Hattori N.
- Journal Title
  
  Neurology.
  
  Volume: 90 Issue: 5 Pages: 1-8
- DOI
  10.1212/wnl.0000000000004888
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-16K09700, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-15KK0354, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-18H04043
[Journal Article] A pilot study of the effect of human breast milk on urinary metabolome analysis in infants.2017
- Author(s)
  Shoji H, Taka H, Kaga N, Ikeda N, Kitamura T, Miura Y, Shimizu T.
- Journal Title
  
  J Pediatr Endocrinol Metab.
  
  Volume: 30 Issue: 9 Pages: 939-946
- DOI
  10.1515/jpem-2017-0179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-15K09727, KAKENHI-PROJECT-26461643
[Journal Article] Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes.2017
- Author(s)
  Namba Y, Togo S, Tulafu M, Kadoya K, Nagahama KY, Taka H, Kaga N, Orimo A, Liu X, Takahashi K.
- Journal Title
  
  Respir Res.
  
  Volume: 18 Issue: 1 Pages: 46-46
- DOI
  10.1186/s12931-017-0529-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-16K15598, KAKENHI-PROJECT-17K10653, KAKENHI-PROJECT-16K15625
[Journal Article] Characteristics of hepatic insulin-sensitive nonalcoholic fatty liver disease.2017
- Author(s)
  Shigiyama F, Kumashiro N, Furukawa Y, Funayama T, Takeno K, Wakui N, Ikehara T, Nagai H, Taka H, Fujimura T, Uchino H, Tamura Y, Watada H, Nemoto T, Shiraga N, Sumino Y, Hirose T.
- Journal Title
  
  Hepatol Commun.
  
  Volume: 1 Issue: 7 Pages: 634-647
- DOI
  10.1002/hep4.1077
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-17K00874, KAKENHI-PROJECT-17H02180
[Journal Article] Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1.2017
- Author(s)
  Sekihara K, Saitoh K, Han L, Ciurea S, Yamamoto S, Kikkawa M, Kazuno S, Taka H, Kaga N, Arai H, Miida T, Andreeff M, Konopleva M, Tabe Y.
- Journal Title
  
  Oncotarget
  
  Volume: in press Issue: 21 Pages: 34552-34564
- DOI
  10.18632/oncotarget.16602
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08653, KAKENHI-PROJECT-16K19855, KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-15K08624
[Journal Article] Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2.2016
- Author(s)
  Takeno K, Tamura Y, Kawaguchi M, Kakehi S, Watanabe T, Funayama T, Furukawa Y, Kaga H, Yamamoto R, Kim M, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Taka H, Fujimura T, Sawada SS, Giacca A, Kanazawa A, Fujitani Y, Kawamori R, Watada H.
- Journal Title
  
  J Clin Endocrinol Metab.
  
  Volume: 101 Issue: 10 Pages: 3676-3684
- DOI
  10.1210/jc.2016-1650
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01834
[Journal Article] Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids.2016
- Author(s)
  Morales J, Hashimoto M, Williams TA, Hirawake-Mogi H, Makiuchi T, Tsubouchi A, Kaga N, Taka H, Fujimura T, Koike M, Mita T, Bringaud F, Concepcion JL, Hashimoto T, Embley TM, Nara T.
- Journal Title
  
  Proc R Soc B
  
  Volume: 283 Issue: 1830 Pages: 20160520-20160520
- DOI
  10.1098/rspb.2016.0520
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-15K08452, KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-16K15268
[Journal Article] Amino group carrier protein-mediated secondary metabolite biosynthesis in Streptomyces.2016
- Author(s)
  Hasebe, F., Matsuda, K., Shiraishi, T., Futamura, Y., Nakano, T., Tomita, T., Ishigami, K., Taka, H., Mineki, R., Fujimura, T., Osada, H., Kuzuyama, T., Nishiyama, M.
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 12 Issue: 11 Pages: 967-972
- DOI
  10.1038/nchembio.2181
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14714, KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-24228001
[Journal Article] Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a2015
- Author(s)
  Kuba M, Matsuzaka T, Matsumori R, Saito R, Kaga N, Taka H, Ikehata K, Okada N,
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Issue: 1 Pages: 17604-17604
- DOI
  10.1038/srep17604
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430145, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-15H03093, KAKENHI-PROJECT-26882008, KAKENHI-PROJECT-25430140, KAKENHI-PROJECT-26560392, KAKENHI-PROJECT-26800271, KAKENHI-PLANNED-23116006, KAKENHI-PROJECT-15H03092
[Journal Article] A clinically attainable dose of L-asparaginase targets2015
- Author(s)
  Sugimoto K, Suzuki HI, Fujimura T, Ono A, Kaga N, Isobe Y, Sasaki M, Taka H,
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 Issue: 11 Pages: 1534-1543
- DOI
  10.1111/cas.12807
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430145, KAKENHI-PROJECT-25430140
[Journal Article] Secreted tyrosine sulfated-eIF5A mediates oxidative stress-induced apoptosis.2015
- Author(s)
  Seko Y, Fujimura T, Yao T, Taka H, Mineki R, Okumura K, Murayama K.
- Journal Title
  
  Sci Rep.
  
  Volume: 8;5 Issue: 1 Pages: 13737-13751
- DOI
  10.1038/srep13737
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K00569, KAKENHI-PROJECT-26430145, KAKENHI-PROJECT-25430140, KAKENHI-PROJECT-26293087
[Journal Article] Effects of sitagliptin on ectopic fat contents and glucose metabolism in type 2 diabetic patients with fatty liver: A pilot study2014
- Author(s)
  Watanabe T, Tamura Y, Kakehi S, Funayama T, Takeno K, Kawaguchi M, Yamamoto L, Sato F, Ikeda S, Taka H, Fujimura T, Fujitani Y, Kawamori R, Watada H
- Journal Title
  
  J Diabetes Invest
  
  Volume: Mar;6(2) Issue: 2 Pages: 164-72
- DOI
  10.1111/jdi.12262
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500867, KAKENHI-PROJECT-25350899, KAKENHI-PROJECT-25350901, KAKENHI-PROJECT-26430145, KAKENHI-PROJECT-15H03097, KAKENHI-PROJECT-25430140
[Journal Article] Sialyl-glycoconjugates in cholesterol-rich microdomains of P388 cells are the triggers for apoptosis induced by Rana catesbeiana oocyte ribonuclease.2014
- Author(s)
  Ogawa Y, Fujimura T, Ozeki Y, et al.
- Journal Title
  
  Glycoconj J.
  
  Volume: 31 Issue: 2 Pages: 171-84
- DOI
  10.1007/s10719-013-9513-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592350, KAKENHI-PROJECT-25430140, KAKENHI-PROJECT-25450306, KAKENHI-PROJECT-25840119
[Journal Article] Increased expression of ERp57/GRP58 is protective against pancreatic beta cell death caused by autophagic failure.2014
- Author(s)
  Yamamoto E, Uchida T, Abe H, Taka H, Fujimura T, Komiya K, Hara A, Ogihara T, Fujitani Y, Ueno T, Takeda S, Watada H.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 453 Issue: 1 Pages: 19-24
- DOI
  10.1016/j.bbrc.2014.09.040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430140, KAKENHI-PROJECT-25860757, KAKENHI-PROJECT-26430145
[Journal Article] A treadmill exercise reactivates the signaling of the mammalian target of rapamycin (mTor) in the skeletal muscles of starved mice.2014
- Author(s)
  Zheng, D.M., Bian, Z., Furuya, N., Oliva Trejo, J.A., Takeda-Ezaki, M., Takahashi, K., Hiraoka, Y., Mineki, R., Taka, H., Ikeda, S., Komatsu, M., Fujimura, T., Ueno, T., Ezaki, J.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 456 Issue: 1 Pages: 519-526
- DOI
  10.1016/j.bbrc.2014.11.118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500868, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-25350901, KAKENHI-PROJECT-25430140
[Journal Article] Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.2013
- Author(s)
  Ouchi T, Fujimura T, et al.
- Journal Title
  
  Nat Chem Biol.
  
  Volume: 9(4):277-83 Issue: 4 Pages: 277-283
- DOI
  10.1038/nchembio.1200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592350, KAKENHI-PROJECT-24228001, KAKENHI-PROJECT-24880011, KAKENHI-PROJECT-25430140
[Journal Article] Detection of 6-nitrotryptophan in proteins by Western blot analysis and its application for peroxynitrite^treated PC 12 cells2007
- Author(s)
  Ikeda K, Yukihiro Hiraoka B, Iwai H, Matsumoto T, Mineki R, Taka H, Takamori K, Ogawa H, Yamakura F.
- Journal Title
  
  Nitric Oxide 16(1)
  
  Pages: 18-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500514
[Journal Article] Detection of 6-nitrotryptophan in proteins by Western blot analysis and its application for peroxynitrite-treated PC12 calls2007
- Author(s)
  Keiichi Ikeda, B.Yukihiro Hiraoka, Hideaki Iwai, Takashi Matsumoto, Naoki Shida Reiko Mineki, Hikari Taka, Kenji Takamori, Hideoki Ogawa, Fumiyuki Yamakura
- Journal Title
  
  Nitric Oxide : Biology and Chemistry 16
  
  Pages: 18-26
- Data Source
  KAKENHI-PROJECT-18500514
[Presentation] 低出生体重倹約型表現型モデルラットの骨格筋と脂肪組織の解析2022
- Author(s)
  根本崇宏、加賀直子、高ひかり、上野隆
- Organizer
  第95回日本生化学大会　2022年11月9日―11日
- Data Source
  KAKENHI-PROJECT-18K07829
[Presentation] 低出生体重倹約型表現型モデルラットの骨格筋と脂肪組織の解析2022
- Author(s)
  根本崇宏、加賀直子、高ひかり、上野隆
- Organizer
  第95回日本生化学大会
- Data Source
  KAKENHI-PROJECT-19K11752
[Presentation] 出生後母乳を介したメチルドナー補充が低栄養出生仔へ与える影響2019
- Author(s)
  加賀直子,高ひかり、上野隆、三浦芳樹
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K11752
[Presentation] Bcat1阻害剤はTsc2欠損マウス腫瘍細胞の増殖を効果的に抑える2019
- Author(s)
  Keiko NISHIKAWA, Tetsuya TAKAGAKI, Moe YASHIMA, Takumi SUZUKI, Toshiyuki KOBAYASHI
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08670
[Presentation] Gene expression profile in the liver of Tsc2 heterozygous mutant (Tsc2+/-) mice: Implications of heterozygosity on lipid metabolism2019
- Author(s)
  Doan Nguyen Minh Thien, Toshiyuki Kobayashi, Keiko Nishikawa, Yoshinobu Sugitani, Takayuki Kitano, Masashi Mizuguchi, Okio Hino
- Organizer
  2019 International Tuberous Sclerosis Complex Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08670
[Presentation] 出生後母乳を介したメチルドナー補充が低栄養出生仔へ与える影響2019
- Author(s)
  加賀直子、高ひかり、上野隆、三浦芳樹、根本崇宏
- Organizer
  第92回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07829
[Presentation] 低出生体重仔への高脂肪食負荷による非感染性慢性疾患（NCDｓ）発症リスクへの影響2018
- Author(s)
  高ひかり、加賀直子、上野隆、三浦芳樹、根本崇宏
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07829
[Presentation] 低出生体重仔への高脂肪食負荷による非感染性慢性疾患（NCDｓ）発症リスクへの影響2018
- Author(s)
  高ひかり、加賀直子、上野隆、三浦芳樹、根本崇宏
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K01834
[Presentation] Aberrant histone methylation and altered gene expression in Tsc2-deficient Eker rat ES cells2018
- Author(s)
  Keiko Nishikawa, Toshiyuki Kobayashi, Yoshinobu Sugitani, Doan Nguyen Minh Thien, Takayuki Kitano, Okio Hino
- Organizer
  International Tuberous Sclerosis Complex Research Conference 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08670
[Presentation] 低出生体重仔における非感染性慢性疾患発症機序の解明2016
- Author(s)
  加賀　直子、高　ひかり、上野隆、根本崇宏
- Organizer
  第10回メタボロームシンポジウム
- Place of Presentation
  山形県鶴岡市
- Year and Date
  2016-10-19
- Data Source
  KAKENHI-PROJECT-16K01834
[Presentation] 妊娠中の摂取カロリー制限母ラットからの出生仔でみられたグルココルチコイドフィードバックの異常と次世代仔への影響2015
- Author(s)
  根本　崇宏、藤村　務、加賀　直子、高　ひかり、上野　隆、柿沼　吉彦
- Organizer
  ＢＭＢ2015
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25430140
[Presentation] 胎生期低栄養が引き起こす血中代謝物の変動解析2015
- Author(s)
  加賀　直子、高　ひかり、根本　崇宏、藤村　務、上野　隆
- Organizer
  第9回メタボロームシンポジウム2015
- Place of Presentation
  三島市民文化会館/三島商工会議所
- Year and Date
  2015-09-30
- Data Source
  KAKENHI-PROJECT-25430140
[Presentation] Search of New Urothelial Cancer Biomarkers2013
- Author(s)
  Tsutomu Fujimura, Hikari Taka, Saiko Kazuno, Reiko Mineki, Kimie Murayama, Takashi Ueno, Jun-ichi Furukawa, Yasuro Shinohara
- Organizer
  HUPO
- Place of Presentation
  神奈川県　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25430140
[Presentation] 呼気中のがんマーカーの探索2013
- Author(s)
  藤村　務、加賀　直子、松森　聖、梶山　美明、高　ひかり、上野　隆
- Organizer
  がんと代謝研究会
- Place of Presentation
  山形県　鶴岡メタボロームキャンパス　レクチャーホール
- Data Source
  KAKENHI-PROJECT-25430140
[Presentation] LPS投与ラット臓器中の6-ニトロトリプトファン含有タンパク質の特異的抗体を用いた解析2007
- Author(s)
  池田啓一、神野宏司、内藤久士、古川覚、松本孝、岩井秀明、高森建二、小川秀興、山倉文幸
- Organizer
  第29回日本フリーラジカル学会学術集会・日本過酸化脂質フリーラジカル学会第31回大会合同学会-プログラム・抄録集
- Place of Presentation
  名古屋国際会議場(愛知)
- Data Source
  KAKENHI-PROJECT-18500514
[Presentation] 敗血症モデルラットにおける6-ニトロトリプトファン含有タンパク質の解析2007
- Author(s)
  池田啓一、神野宏司、内藤久士、古川覚、高森建二、小川秀興、山倉文幸
- Organizer
  第7回日本NO学会学術集会プログラム抄録集
- Place of Presentation
  ピアザ淡海(滋賀)
- Data Source
  KAKENHI-PROJECT-18500514
[Presentation] Proteomic analysis of 6-nitrotryptophan-containing proteins in peroxynitrite-treated pc12 cells2006
- Author(s)
  Ikeda K, Iwai H, Matsumoto T, Mineki R, Taka H, Takamori K, Ogawa H Yamakura F
- Organizer
  11th Meeting of the International Study Group of Tryptophan Research-2006 (ISTRY-2006 Tokyo), Program and Abstracts
- Place of Presentation
  Sanjyo-Kaikan, Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-18500514
[Presentation] パーオキシナイトライト処理PC12細胞における6-ニトロトリプトファン免疫反応タンパク質の同定2006
- Author(s)
  池田啓一、岩井秀明、松本孝、峯木礼子、高ひかり、高森建二、山倉文幸
- Organizer
  第6回日本NO学会学術集会-プログラム・抄録集-
- Place of Presentation
  シェーンバッハ・サボー(東京)
- Data Source
  KAKENHI-PROJECT-18500514
[Presentation] Formation of 6-nitrotryptophan in purified proteins by reactive nitrogen species : a possible new biomarker2006
- Author(s)
  Yamakura F, Ikeda K, Matsumoto T, Taka H, Kaga N
- Organizer
  11th Meeting of the International Study Group of Tryptophan Research-2006 (ISTRY-2006 Tokyo), Program and Abstracts
- Place of Presentation
  Sanjyo-Kaikan, Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-18500514
[Presentation] Identification of immunoreactive proteins in ONOO-treated PC12 cells by using affinity-purified anti-6-nitrotryptophan antibody2006
- Author(s)
  Ikeda K, Hiraoka BY, Matsumoto T, Mineki R, Taka H, Shida N, Amamiya Y, Takamori K, Ohmori D, Yamakura F
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-18500514
[Presentation] Search of cancer markers in exhaled breath.
- Author(s)
  Fujimura T, Matsumori S , Kaga K, Taka H, Kajiyama Y, Ueno T
- Organizer
  Metabolomics 2014
- Place of Presentation
  山形県鶴岡市　鶴岡第一ホテル・MARICA
- Year and Date
  2014-06-23 – 2014-06-26
- Data Source
  KAKENHI-PROJECT-25430140

1. Kaga Naoko (80338342)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
2. FUMIYUKI Yamakura (20053358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
3. NAITO Hisashi (70188861)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. IKEDA Keiichi (90453597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. FUJIMURA Tsutomu (70245778)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
6. SAITO Seiichi (80235043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MIYAJIMA Masakazu (60200177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ARAI Hajime (70167229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OOYAMA Kazutaka (20286719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Kobayashi Toshiyuki (40260070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 村山季美枝 (20053118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 三浦芳樹 (90279240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YASUDA Sumio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NEMOTO takahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. FUNAYAMA Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. SASAZAWA Yukiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. TAMURA Yoshihumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. KAKEHI Saori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. MINEKI Shigeru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. NORIHIKO Furuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 田部陽子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 三井田孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 斉木臣二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 山野晃史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 上野紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 峯木礼子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 長田太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 奈良武司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 橋本宗明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 坪内暁子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. モラレスホルヘ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 中野雄司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKA HIKARI 高 ひかり

高 ひかり タカ ヒカリ

TAKA Hikari 高 ひかり

Research Projects

Research Products

Co-Researchers

体質と環境のミスマッチから生じる非感染性慢性疾患(NCDs)発症リスクの機構解明Principal Investigator

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Metabolomics reveals risk factors for the development of diseases in low-birth weight infants for preemptive medicine

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Metabolic changes and epigenetic abnormalities caused by tuberous sclerosis compex (TSC) gene mutation

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Realization of Preemptive Medicine by elucidating the onset mechanism of diabetes attributed to mismatch between Constitution and EnvironmentPrincipal Investigator

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Search for new urothelial cancer biomarkersPrincipal Investigator

Principal Investigator

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Proteomics analysis of the modified proteins in rat by reactive oxygen and reactive nitrogen species generated with exercise

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Proteome analysis of cerebrospinal fluid proteins in idiopathic normal pressure hydrocephalus.

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[Book] 腎臓病実験法ハンドブック2013

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[Book] "Formation of 6-Nitrotryptophan in purified proteins by reactive nitrogen species : a possible new biomarker" in International Congress Series 13042007

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[Book] "Proteomic analysis of 6-nitrotryptophan containing proteins in peroxynitrite-treated pc12 cells" in International Congress Series 13042007

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[Journal Article] The fluid factor OVGP1 provides a significant oviductal microenvironment for the reproductive process in golden hamster2023

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[Journal Article] Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex2023

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[Journal Article] Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice2023

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[Journal Article] The Effect of Long-Term Inorganic Iodine on Intrathyroidal Iodothyronine Content and Gene Expression in Mice with Graves' Hyperthyroidism2023

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TAKA HIKARI 高ひかり

高ひかりタカヒカリ

TAKA Hikari 高ひかり