AKIYAMA NOBUKO 秋山伸子

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Akiyama Nobuko 秋山伸子

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Researcher Number	60342739
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員
Affiliation (based on the past Project Information) *help	2018 – 2023: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員 2017: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related / Biological Sciences / General medical chemistry
Keywords	Principal Investigator 胸腺上皮細胞 / 自己免疫寛容 / 免疫寛容 / 胸腺髄質上皮細胞 / 組織特異的抗原 / 発生・分化 / 免疫学 / 分化 / 転写因子

Regulatory mechanisms of random ectopic expression in thymic epithelial cells that define immunological "self"Principal Investigator
- Principal Investigator
  
  秋山伸子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Differentiation and maintenance mechanisms of thymic epithelial cells that induce autoimmune tolerancePrincipal Investigator
- Principal Investigator
  
  Akiyama Nobuko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Identification of a novel transcription factor essential for the induction of thymic self-tolerancePrincipal Investigator
- Principal Investigator
  
  秋山伸子
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute of Physical and Chemical Research
Identification of a novel transcription factor required for differentiation of medullary thymic epithelial cellsPrincipal Investigator
- Principal Investigator
  
  Akiyama Nobuko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Institute of Physical and Chemical Research

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity2024
- Author(s)
  Takakura Y、Machida M、Terada N、Katsumi Y、Kawamura S、Horie K、Miyauchi M、Ishikawa T、Akiyama N、Seki T、Miyao 、Hayama Mio、Endo R、Ishii H、Maruyama Y、Hagiwara N、Kobayashi T J.、Yamaguchi N、Takano H、Akiyama T、Yamaguchi N
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 953-953
- DOI
  10.1038/s41467-024-45206-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06385, KAKENHI-PROJECT-20K07332, KAKENHI-PROJECT-21K06543, KAKENHI-PROJECT-21K08121, KAKENHI-PROJECT-22K20706
[Journal Article] <scp>T‐cell receptor</scp> repertoire analysis of <scp>CD4</scp>‐positive T cells from blood and an affected organ in an autoimmune mouse model2023
- Author(s)
  Ishikawa Tatsuya、Horie Kenta、Takakura Yuki、Ohki Houko、Maruyama Yuya、Hayama Mio、Miyauchi Maki、Miyao Takahisa、Hagiwara Naho、Kobayashi Tetsuya J.、Akiyama Nobuko、Akiyama Taishin
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 12 Pages: 929-941
- DOI
  10.1111/gtc.13079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19391, KAKENHI-PROJECT-23K06385, KAKENHI-PROJECT-20K07332, KAKENHI-PROJECT-22K20706
[Journal Article] Sample Preparation and Integrative Data Analysis of a Droplet-based Single-Cell ATAC-sequencing Using Murine Thymic Epithelial Cells2023
- Author(s)
  Ishikawa Tatsuya、Ishii Hiroto、Miyao Takahisa、Horie Kenta、Miyauchi Maki、Akiyama Nobuko、Akiyama Taishin
- Journal Title
  
  BIO-PROTOCOL
  
  Volume: 13 Issue: 0 Pages: 4588-4588
- DOI
  10.21769/bioprotoc.4588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19391, KAKENHI-PROJECT-23K06385, KAKENHI-PROJECT-20K07332
[Journal Article] Acute irradiation causes a long-term disturbance in the heterogeneity and gene expression profile of medullary thymic epithelial cells2023
- Author(s)
  Horie Kenta、Namiki Kano、Kinoshita Kyouhei、Miyauchi Maki、Ishikawa Tatsuya、Hayama Mio、Maruyama Yuya、Hagiwara Naho、Miyao Takahisa、Murata Shigeo、Kobayashi Tetsuya J.、Akiyama Nobuko、Akiyama Taishin
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1186154-1186154
- DOI
  10.3389/fimmu.2023.1186154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19391, KAKENHI-PROJECT-23K06385, KAKENHI-PROJECT-20K07332, KAKENHI-PLANNED-23H04918
[Journal Article] ntegrative analysis of scRNAs-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator2022
- Author(s)
  T Miyao, M Miyauchi, S. T Kelly, T W. Terooatea, T Ishikawa, E Oh, S Hirai, K Horie, Y Takakura, H Ohki, M Hayama, Y Maruyama, T Seki, H Yabukami, M Yoshida, A Inoue, A Sakaue- Sawano, A Miyawaki, M Muratani, A Minoda, N Akiyama, T Akiyama
- Journal Title
  
  eLife
  
  Volume: in press Pages: 1-16
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07332
[Journal Article] Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator2022
- Author(s)
  Miyao T、Miyauchi M、Kelly S T、T Tommy W、Ishikawa T、Oh E、Hirai S、Horie K、Takakura Y、Ohki H、Hayama M、Maruyama Y、Seki T、Ishii H、Yabukami H、Yoshida M、Inoue A、Sakaue-Sawano A、Miyawaki A、Muratani M、Minoda A、Akiyama N、Akiyama T
- Journal Title
  
  eLife
  
  Volume: 11 Pages: 73998-73998
- DOI
  10.7554/elife.73998
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07332, KAKENHI-PROJECT-21K19391, KAKENHI-PROJECT-22K20706, KAKENHI-PLANNED-19H05754, KAKENHI-PROJECT-20H03441
[Journal Article] Aire controls heterogeneity of medullary thymic epithelial cells for the expression of self-antigens2022
- Author(s)
  Nishijima H, Matsumoto M, Morimoto J, Hosomichi K, Akiyama N, Akiyama T, Oya T, Tsuneyama K, Yoshida H, Matsumoto M.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 15 Issue: 2 Pages: 303-320
- DOI
  10.4049/jimmunol.2100692
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07626, KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06496, KAKENHI-PUBLICLY-19H04821, KAKENHI-WRAPUP-21H00461, KAKENHI-INTERNATIONAL-16K21731, KAKENHI-PROJECT-20K07332, KAKENHI-PROJECT-21K19391, KAKENHI-PROJECT-20H03441
[Journal Article] Integrative analysis of scRNAs-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator2022
- Author(s)
  T Miyao, M Miyauchi, S. T Kelly, T W. Terooatea, T Ishikawa, E Oh, S Hirai, K Horie, Y Takakura, H Ohki, M Hayama, Y Maruyama, T Seki, H Yabukami, M Yoshida, A Inoue, A Sakaue-Sawano, A Miyawaki, M Muratani, A Minoda, N Akiyama, T Akiyama
- Journal Title
  
  eLife
  
  Volume: in press Pages: 1-16
- Data Source
  KAKENHI-PUBLICLY-19H04821
[Journal Article] In Pursuit of Adult Progenitors of Thymic Epithelial Cells2021
- Author(s)
  Ishikawa T, Akiyama N, Akiyama T
- Journal Title
  
  Front Immunol
  
  Volume: 12 Pages: 621824-621824
- DOI
  10.3389/fimmu.2021.621824
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08622, KAKENHI-PUBLICLY-19H04821, KAKENHI-PROJECT-20K07332, KAKENHI-PROJECT-20H03441
[Journal Article] The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression2020
- Author(s)
  Ito-Kureha Taku、Miyao Takahisa、Nishijima Saori、Suzuki Toru、Koizumi Shin-ichi、Villar-Briones Alejandro、Takahashi Akinori、Akiyama Nobuko、Morita Masahiro、Naguro Isao、Ishikawa Hiroki、Ichijo Hidenori、Akiyama Taishin、Yamamoto Tadashi
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 6169-6169
- DOI
  10.1038/s41467-020-19975-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07079, KAKENHI-PROJECT-20K07332, KAKENHI-PUBLICLY-19H04821, KAKENHI-PROJECT-18H03995, KAKENHI-PROJECT-17K08622, KAKENHI-PROJECT-18K07237, KAKENHI-PROJECT-19K22547, KAKENHI-PROJECT-20H03441
[Journal Article] Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight2019
- Author(s)
  Horie Kenta、Kato Tamotsu、Kudo Takashi、Sasanuma Hiroki、Miyauchi Maki、Akiyama Nobuko、Miyao Takahisa、Seki Takao、Ishikawa Tatsuya、Takakura Yuki、Shirakawa Masaki、Shiba Dai、Hamada Michito、Jeon Hyojung、Yoshida Nobuaki、Inoue Jun-ichiro、Muratani Masafumi、Takahashi Satoru、Ohno Hiroshi、Akiyama Taishin
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 19866-19866
- DOI
  10.1038/s41598-019-56432-9
- NAID
  120007132915
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08622, KAKENHI-INTERNATIONAL-16K21739, KAKENHI-ORGANIZER-16H06573, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-18H04965, KAKENHI-PUBLICLY-18H04989, KAKENHI-PROJECT-17H04038, KAKENHI-ORGANIZER-15H05935
[Journal Article] 胸腺抗原提示細胞の成熟におけるTNFレセプターファミリーシグナルの役割2019
- Author(s)
  関崇生、堀江健太、秋山伸子、秋山泰身
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 71(5) Pages: 482-489
- Data Source
  KAKENHI-PROJECT-17K08622
[Journal Article] Down-regulation of GATA1-dependent erythrocyte-related genes in the spleens of mice exposed to a space travel2019
- Author(s)
  Horie Kenta、Sasanuma Hiroki、Kudo Takashi、Fujita Shin-ichiro、Miyauchi Maki、Miyao Takahisa、Seki Takao、Akiyama Nobuko、Takakura Yuki、Shimbo Miki、Jeon Hyojung、Shirakawa Masaki、Shiba Dai、Yoshida Nobuaki、Muratani Masafumi、Takahashi Satoru、Akiyama Taishin
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 444-444
- DOI
  10.1038/s41598-019-44067-9
- NAID
  120007133360
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08622, KAKENHI-PUBLICLY-18H04965, KAKENHI-PUBLICLY-18H04989, KAKENHI-PROJECT-17H04038, KAKENHI-ORGANIZER-15H05935
[Journal Article] Quantitative analysis reveals reciprocal regulations underlying recovery dynamics of thymocytes and thymic environment in mice2019
- Author(s)
  Kaneko Kazumasa B.、Tateishi Ryosuke、Miyao Takahisa、Takakura Yuki、Akiyama Nobuko、Yokota Ryo、Akiyama Taishin、Kobayashi Tetsuya J.
- Journal Title
  
  Communications Biology
  
  Volume: 2 Issue: 1 Pages: 444-444
- DOI
  10.1038/s42003-019-0688-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08622, KAKENHI-PUBLICLY-18H05096, KAKENHI-PUBLICLY-18H04989, KAKENHI-ORGANIZER-19H05794, KAKENHI-PLANNED-19H05799, KAKENHI-PROJECT-17H04038
[Journal Article] 胸腺内制御性T細胞分化におけるTRAF6の役割2019
- Author(s)
  堀江健太、秋山伸子、関崇生、高倉勇気、石川龍也、秋山泰身
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 72(6) Pages: 596-601
- Data Source
  KAKENHI-PROJECT-17K08622
[Journal Article] Long-term hindlimb unloading causes a preferential reduction of medullary thymic epithelial cells expressing autoimmune regulator (Aire)2018
- Author(s)
  Kenta Horie; Takashi Kudo; Riko Yoshinaga; Nobuko Akiyama; Hiroki Sasanuma; Tetsuya J Kobayashi; Miki Shimbo; Hyojung Jeon; Takahisa Miyao; Maki Miyauchi; Masaki Shirakawa; Dai Shiba; Nobuaki Yoshida; Masafumi Muratani; Satoru Takahashi; Taishin Akiyama
- Journal Title
  
  Biochemical and Biophysical Research Communications (BBRC)
  
  Volume: in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08622
[Journal Article] Long-term hindlimb unloading causes a preferential reduction of medullary thymic epithelial cells expressing autoimmune regulator (Aire)2018
- Author(s)
  Horie Kenta、Kudo Takashi、Yoshinaga Riko、Akiyama Nobuko、Sasanuma Hiroki、Kobayashi Tetsuya J.、Shimbo Miki、Jeon Hyojung、Miyao Takahisa、Miyauchi Maki、Shirakawa Masaki、Shiba Dai、Yoshida Nobuaki、Muratani Masafumi、Takahashi Satoru、Akiyama Taishin
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 501 Issue: 3 Pages: 745-750
- DOI
  10.1016/j.bbrc.2018.05.060
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08622, KAKENHI-PUBLICLY-18H04965, KAKENHI-PUBLICLY-18H04989, KAKENHI-PUBLICLY-18H05096, KAKENHI-PROJECT-17H04038, KAKENHI-ORGANIZER-15H05935
[Journal Article] 免疫機能に対する宇宙滞在の影響2018
- Author(s)
  秋山泰身、堀江健太、良永理子、秋山伸子
- Journal Title
  
  生体の科学
  
  Volume: 69(2) Pages: 147-151
- Data Source
  KAKENHI-PROJECT-17K08622
[Journal Article] 宇宙環境ストレスがリンパ組織胸腺に与える影響2018
- Author(s)
  秋山泰身、堀江健太、関崇生、秋山伸子
- Journal Title
  
  細胞
  
  Volume: 50(12) Pages: 630-633
- Data Source
  KAKENHI-PROJECT-17K08622
[Presentation] B 型胸腺腫における転写制御因子 AIRE と ASCL1 の発現低下は関連自己免疫疾患発症へ寄与する2024
- Author(s)
  秋山伸子
- Organizer
  第43回胸腺研究会
- Data Source
  KAKENHI-PROJECT-20K07332
[Presentation] B 型胸腺腫における転写制御因子 AIRE と ASCL1 の発現低下は関連自己免疫疾患発症へ寄与する2024
- Author(s)
  秋山伸子
- Organizer
  第43回胸腺研究会
- Data Source
  KAKENHI-PROJECT-23K06385
[Presentation] 胸腺腫の１細胞遺伝子発現解析2022
- Author(s)
  秋山伸子
- Organizer
  第41回日本胸腺研究会
- Data Source
  KAKENHI-PROJECT-20K07332
[Presentation] 胸腺腫の１細胞遺伝子発現解析2022
- Author(s)
  秋山伸子
- Organizer
  第41回日本胸腺研究会
- Data Source
  KAKENHI-PUBLICLY-19H04821
[Presentation] Single-cell RNA-sequencing analysis of murine thymic epithelial cells2019
- Author(s)
  Nobuko Akiyama, Takao Seki, Kenta Horie, Taishin Akiyama
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08622
[Presentation] Dependency of thymic dendritic cell maturation on RANK and CD40 signaling2018
- Author(s)
  Seki T, Horie K, Akiyama N, Akiyama T
- Organizer
  The 47th Annual Meeting of the Japanese Society fo Immunology
- Data Source
  KAKENHI-PROJECT-17K08622
[Presentation] Impacts of space flight and its ground models on the thymus2018
- Author(s)
  Horie K, Seki T, Akiyama N, Kato T, Ohno H, Takahashi S, Akiyama T
- Organizer
  The 47th Annual Meeting of the Japanese Society fo Immunology
- Data Source
  KAKENHI-PROJECT-17K08622

1. MORIMOTO Junko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 秋山泰身

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 鈴木亨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 松本満

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AKIYAMA NOBUKO 秋山 伸子

Akiyama Nobuko 秋山 伸子

Research Projects

Research Products

Co-Researchers

Regulatory mechanisms of random ectopic expression in thymic epithelial cells that define immunological "self"Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Differentiation and maintenance mechanisms of thymic epithelial cells that induce autoimmune tolerancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of a novel transcription factor essential for the induction of thymic self-tolerancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of a novel transcription factor required for differentiation of medullary thymic epithelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <scp>T‐cell receptor</scp> repertoire analysis of <scp>CD4</scp>‐positive T cells from blood and an affected organ in an autoimmune mouse model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sample Preparation and Integrative Data Analysis of a Droplet-based Single-Cell ATAC-sequencing Using Murine Thymic Epithelial Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acute irradiation causes a long-term disturbance in the heterogeneity and gene expression profile of medullary thymic epithelial cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ntegrative analysis of scRNAs-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator2022

Author(s)

Journal Title

Data Source

[Journal Article] Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aire controls heterogeneity of medullary thymic epithelial cells for the expression of self-antigens2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Integrative analysis of scRNAs-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator2022

Author(s)

Journal Title

Data Source

[Journal Article] In Pursuit of Adult Progenitors of Thymic Epithelial Cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight2019

Author(s)

Journal Title

AKIYAMA NOBUKO 秋山伸子

Akiyama Nobuko 秋山伸子