Harashima Nanae 原嶋奈々江

… Alternative Names

HARASHIMA Nanae 原嶋奈々江

原嶋奈々江ハラシマナナエ

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Researcher Number	60345311
Other IDs
Affiliation (Current)	2025: 琉球大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2011 – 2015: 島根大学, 医学部, 助教 2009: 東京医科歯科大学, 大学院・医歯学総合研究科, 助手 2008 – 2009: Shimane University, 医学部, 助教 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, 助手 2003: 東京医科歯科大学, 大学院・医歯学総合研究科, 助手
Review Section/Research Field	Principal Investigator Tumor therapeutics / Tumor immunology / General surgery Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 癌 / 免疫 / オートファジー / アポトーシス / 治療抵抗性 / 低酸素 / シグナル伝達 / 免疫学 / 薬剤反応性 / エピジェネティクス / 腫瘍 … More Except Principal Investigator … More ATL / HTLV-I / 細胞・組織 / ワクチン / 免疫学 / トラスレーショナルリサーチ / 癌 / ウイルス / CTL / animal model / DNA vaccine / siRNA / Tax Less

Restoration of immune susceptibility to cancer cells regulated by autophagy and hypoxic responsesPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Nanae
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Shimane University
Cancer cell death and autophagy induced by the signaling of immune adjuvant receptorsPrincipal Investigator
- Principal Investigator
  
  HARASHIMA Nanae
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor immunology
- Research Institution
  Shimane University
Enhancing effect in the expression of tumor antigens and T-cell sensitivity against tumor cells after treatment with epigenetic drugs.Principal Investigator
- Principal Investigator
  
  HARASHIMA Nanae
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General surgery
- Research Institution
  Shimane University
Anti-viral immuno therapeutic approaches for adult T-cell leukemia
- Principal Investigator
  
  KANNAGI Mari
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
ラットモデルを用いたヒト成人T細胞白血病に対する免疫療法の開発
- Principal Investigator
  
  大橋貴
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University

All 2016 2015 2014 2013 2012 2011 2009 2008 2006 2005 2004 Other

All Journal Article Presentation Patent

[Journal Article] Detection of an immunogenic HERV-E envelope with selective expression in clear cell kidney cancer2016
- Author(s)
  Cherkasova E., Scrivani C., Doh S., Weisman Q., Takahashi Y., Harashima N., Yokoyama H., Srinivasan R., Linehan WM., Lerman MI., and Childs RW.
- Journal Title
  
  Cancer Research
  
  Volume: 76 (8) Issue: 8 Pages: 2177-2185
- DOI
  10.1158/0008-5472.can-15-3139
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430150, KAKENHI-PROJECT-26461580
[Journal Article] The roles of ROS and caspases in TRAIL-Induced apoptosis and necroptosis in human pancreatic cancer cells2015
- Author(s)
  Zhang M, Harashima N, Moritani T, Huang W, Harada M.
- Journal Title
  
  PLoS One
  
  Volume: 10 (5) Issue: 5 Pages: e0127386-e0127386
- DOI
  10.1371/journal.pone.0127386
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430150
[Journal Article] Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state.2015
- Author(s)
  Tongu M, Harashima N, Tamada K, Chen L, Harada M
- Journal Title
  
  Cancer Science
  
  Volume: 106 Issue: 1 Pages: 9-17
- DOI
  10.1111/cas.12568
- NAID
  120005982740
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24501331, KAKENHI-PROJECT-25290057, KAKENHI-PROJECT-25430150
[Journal Article] Identification of programmed death ligand 1-derived peptides capable of inducing cancer-reactive cytotoxic T lymphocytes from HLA-A24+ patients with renal cell carcinoma2015
- Author(s)
  Minami T., Minami T., Shimizu N., Yamamoto Y., De Velasco MA., Nozawa M., Yoshimura K., Harashima N., Harada M., Uemura H.
- Journal Title
  
  Journal of Immunotherapy
  
  Volume: 38 (7) Issue: 7 Pages: 285-291
- DOI
  10.1097/cji.0000000000000090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430150, KAKENHI-PROJECT-25293336
[Journal Article] Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells2015
- Author(s)
  Hari Y., Harashima N., Tajima Y., Harada M.
- Journal Title
  
  Oncotarget
  
  Volume: 6 (39) Issue: 39 Pages: 41902-41915
- DOI
  10.18632/oncotarget.5881
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430150, KAKENHI-PROJECT-25462112
[Journal Article] Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition2014
- Author(s)
  Tamaki H, Harashima N, Hiraki M, Aichi N, Nishimura N, Shiina H, Naora K, Harada M.
- Journal Title
  
  Oncotarget
  
  Volume: 5 (22) Pages: 11399-11412
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430150
[Journal Article] Identification of erythropoietin receptor-derived peptides having the potential to induce cancer-reactive cytotoxic T lymphocytes from HLA-A24+ patients with renal cell carcinoma.2014
- Author(s)
  Minami T, Minami T, Shimizu N, Yamamoto Y, De Velasco M, Nozawa M, Yoshimura K, Harashima N, Harada M, Uemura H.
- Journal Title
  
  International Immunopharmacology
  
  Volume: 20 Issue: 1 Pages: 59-65
- DOI
  10.1016/j.intimp.2014.02.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24501331, KAKENHI-PROJECT-25430150
[Journal Article] Transfection of poly(I:C) can induce ROS-triggered apoptosis and IFN--mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system2014
- Author(s)
  Harashima N, Minami T, Uemura H, Harada M
- Journal Title
  
  Molecular Cancer
  
  Volume: 13 Issue: 1 Pages: 217-217
- DOI
  10.1186/1476-4598-13-217
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24501331, KAKENHI-PROJECT-25293336, KAKENHI-PROJECT-25430150
[Journal Article] Pifithrin-mu, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells2013
- Author(s)
  Sekihara M, Harashima N, Tongu M, Tamaki Y, Uchida N, Inomata T, Harada M.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 11 Pages: e78772-e78772
- DOI
  10.1371/journal.pone.0078772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501331, KAKENHI-PROJECT-25430150
[Journal Article] The HSP70 and autophagy inhibitor pifithrin-mu enhances the antitumor effects of TRAIL on human pancreatic cancer2013
- Author(s)
  Monma H, Harashima N, et al.
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 12 Issue: 4 Pages: 341-351
- DOI
  10.1158/1535-7163.mct-12-0954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701074, KAKENHI-PROJECT-24501331, KAKENHI-PROJECT-25430150, KAKENHI-PROJECT-25462112
[Journal Article] Roles of the PI3 K/Akt pathway and autophagy in TLR3 sig naling-induced apoptosis and growth arr est of human prostate cancer cells2012
- Author(s)
  Harashima, N., Inao, T., Imamura, R., et. al.
- Journal Title
  
  Cancer Immunol. Immunother
  
  Volume: (in press) Issue: 5 Pages: 667-676
- DOI
  10.1007/s00262-011-1132-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590329, KAKENHI-PROJECT-21591668, KAKENHI-PROJECT-22501023, KAKENHI-PUBLICLY-23114505, KAKENHI-PROJECT-23390092, KAKENHI-PROJECT-23701074, KAKENHI-PROJECT-24590374
[Journal Article] Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce anti-tumor T cell immunity in vivo2012
- Author(s)
  Miki Tongu, Nanae Harashima, Hiroyuki Monma, Touko Inao, Takaya Yamada, Hideyuki Kawauchi, Mamoru Harada
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 62 Issue: 2 Pages: 383-391
- DOI
  10.1007/s00262-012-1343-0
- NAID
  120005982738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659796, KAKENHI-PROJECT-23701074, KAKENHI-PROJECT-24501331
[Journal Article] Antitumor effects of cytoplasmic delivery of an innate adjuvant receptor ligand, poly(I : C), on human breast cancer2012
- Author(s)
  Harada M., et al.(8人中8番目)
- Journal Title
  
  Breast Cancer Research and Treatment
  
  Volume: (in press) Issue: 1 Pages: 89-100
- DOI
  10.1007/s10549-011-1930-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591668, KAKENHI-PROJECT-22501023, KAKENHI-PROJECT-23701074, KAKENHI-PROJECT-24501331
[Journal Article] Combining a peptide vaccine with oral ingestion of Lentinula edodes mycelia extract enhances anti-tumor activity in B16 melanoma-bearing mice2012
- Author(s)
  Tanaka K, Harashima N, et al.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 61 Issue: 11 Pages: 2143-2152
- DOI
  10.1007/s00262-012-1275-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701074, KAKENHI-PROJECT-24501331
[Journal Article] Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages2009
- Author(s)
  Y.Shimizu, A.Takamori, A.Utsunomiya, M.Kurimura, Y.Yamano, M.Hishizawa, A.Hasegawa, F.Kondo, K.Kurihara, N.Harashima, T.Watanabe, J.Okamura, T.Masuda, M.Kannagi
- Journal Title
  
  Cancer Science 100
  
  Pages: 481-489
- NAID
  10025143429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013028
[Journal Article] Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages2009
- Author(s)
  Y. Shimizu, A. Takamori, A. Utsunomiya, M. Kurimura, Y.Yamano, M. Hishizawa. A. Hasegawa, F. Kondo, K. Kurihara, N. Harashima, T. Watanabe, J. Okamura, T. Masuda, and M. Kannagi
- Journal Title
  
  Cancer Science 100
  
  Pages: 481-489
- NAID
  10025143429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013028
[Journal Article] Roles of proinflammatory cytokines and the Fas/Fas ligand interaction in the pathogenesis of inflammatory myopathies.2009
- Author(s)
  Kondo M, Murakawa Y, Harashima N, Kobayashi S, Yamaguchi S, Harada M
- Journal Title
  
  Immunology 128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790930
[Journal Article] Immunogenic chemotherapy with cyclophosphamide and doxorubicin against established murine carcinoma.2009
- Author(s)
  Tongu M, Harashima N, Yamada T, Harada T, Harada M
- Journal Title
  
  Cancer Immunol Immunother. 59(5)
  
  Pages: 767-777
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790930
[Journal Article] Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages.2009
- Author(s)
  Y. Shimizu, A. Takamori, A. Utsunomiya, M. Kurimura, Y. Yamano, M. Hishizawa, A. Hasegawa, F. Kondo, K. Kurihara, N. Harashima, T. Watanabe, J. Okamura, T. Masuda, M. Kannagi
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 481-489
- NAID
  10025143429
- Data Source
  KAKENHI-PROJECT-17013028
[Journal Article] Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages.2009
- Author(s)
  Shimizu Y, Takamori A, Utsunomiya A, Kurimura M, Yamano Y, Hishizawa M, Hasegawa A, Kondo F, Kurihara K, Harashima N, Watanabe T, Okamura J, Masuda T, Kannagi M
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 481-489
- NAID
  10025143429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790930
[Journal Article] Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells2008
- Author(s)
  Takahashi, Y., Harashima, N. (eaually contributed)
- Journal Title
  
  Journal of Clinical Investigation 118
  
  Pages: 1099-1109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790930
[Journal Article] ( *These authors contributed equally to this work. ) Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells.2008
- Author(s)
  Takahashi Y*, Harashima N*, Kajigaya S, Yokoyama H, Cherkasova E, McCoy JP, Hanada K, Mena O, Kurlander R, Tawab A, Srinivasan R, Lundqvist A, Malinzak E, Geller N, Lerman MI, Childs RW
- Journal Title
  
  J Clin Invest. 118
  
  Pages: 1099-1109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790930
[Journal Article] Human T-cell leukemia virus type-I (HTLV-I)-specific T-cell responses detected using three-divided glutathione-S-transferase (GST)-Tax fusion proteins.2006
- Author(s)
  K. Kurihara, Y. Shimizu, A. Takamori, N. Harashima, M. Noji, T. Masuda, A. Utsunomiya, J. Okamura, M. Kannagi
- Journal Title
  
  Immunol. Methods 313
  
  Pages: 61-73
- Data Source
  KAKENHI-PROJECT-17013028
[Journal Article] Human T-cell leukemia virus type-I (HTLV-I)-specific T-cell responses detected using three-divided glutathione-S-transferase (GST)-Tax fusion proteins.2006
- Author(s)
  K.Kurihara, Y.Shimizu, A.Takamori, N.Harashima, M.Noji, T.Masuda, A.Utsunomiya, J.Okamura, M.Kannagi
- Journal Title
  
  J. Immunol. Methods 313
  
  Pages: 61-73
- Data Source
  KAKENHI-PROJECT-17013028
[Journal Article] umor immunity against adult T-cell leukemia.2005
- Author(s)
  M. Kannagi, N. Harashima, K. Kurihara, T. Ohashi, A. Utsunomiya, R. Tanosaki, M. Masuda, M. Tomonaga, J. Okamura
- Journal Title
  
  Cancer Sci 96
  
  Pages: 249-255
- Data Source
  KAKENHI-PROJECT-17013028
[Journal Article] Identification of Two New HLA-A*1101-restricted Tax Epitopes Recognized by Cytotoxic T-lymphocytes in an Adult T-cell Leukemia Patient after Hematopoietic Stem Cell Transplantation.2005
- Author(s)
  N.Harashima, et al.
- Journal Title
  
  J.Virol. 79
  
  Pages: 10088-10092
- Data Source
  KAKENHI-PROJECT-17013028
[Journal Article] Identification of Two New HLA-A*1101-restricted Tax Epitopes Recognized by Cytotoxic T-lymphocytes in an Adult T-cell Leukemia Patient after Hematopoietic Stem Cell Transplantation.2005
- Author(s)
  N. Harashima, R. Tanosaki, Y. Shimizu, K. Kurihara, T. Masuda, J. Okamura, M. Kannagi
- Journal Title
  
  J. Virol. J. 79
  
  Pages: 88-1009
- Data Source
  KAKENHI-PROJECT-17013028
[Journal Article] Potential immunogenicity of Adult T cell Leukemia cells in vivo.2005
- Author(s)
  K. Kurihara, N. Harashima, S. Hanabuchi, M. Masuda, A. Utsunomiya, R. Tanosaki, M. Tomonaga, T. Ohashi, A. Hasegawa, T. Masuda, J. Okamura, Y. Tanaka, M. Kannagi
- Journal Title
  
  Int. J. Cancer 114
  
  Pages: 257-267
- Data Source
  KAKENHI-PROJECT-17013028
[Patent] Peptide having HTLV-1-specific CTL-inducing activity2008
- Inventor(s)
  Harashima N, Kannagi M
- Industrial Property Rights Holder
  Tokyo Medical and Dental University
- Filing Date
  2008-06-25
- Data Source
  KAKENHI-PROJECT-17013028
[Patent] LA-A11拘束性Tax抗腫瘍エピトープ2005
- Inventor(s)
  原嶋奈々江、神奈木真理、田野崎隆二
- Industrial Property Rights Holder
  東京医科歯科大学
- Filing Date
  2005-09-22
- Data Source
  KAKENHI-PROJECT-17013028
[Patent] HLA-A11拘束性Tax抗腫瘍エピトープ2004
- Inventor(s)
  原嶋奈々江, 神奈木真理, 田野崎隆二
- Industrial Property Rights Holder
  東京医科歯科大学
- Filing Date
  2004-09-27
- Data Source
  KAKENHI-PROJECT-17013028
[Presentation] Bcl-xL inhibition sensitizes human pancreatic cancer cells to TRAIL2015
- Author(s)
  波里瑶子、原嶋奈々江、田島義証、原田守
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋国際会議場（愛知）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] HIF-2alpha, but not HIF-1alpha, determines immune resistance of pancreatic cancer cells to TRAIL and T cells via survivin2015
- Author(s)
  Harada M., Harashima N.
- Organizer
  第44回日本免疫学会
- Place of Presentation
  札幌コンベンションセンター（北海道）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Regulatory roles of HIF-2alpha and survivin in TRAIL- and gannma-deltaT cell-mediated cytotoxicity of human pancreatic cancer cells2015
- Author(s)
  Harashima N., Harada M.
- Organizer
  19th JACI & 23rd MMCB, がん免疫療法・マクロファージ国際会議2015
- Place of Presentation
  東京大学（東京）
- Year and Date
  2015-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] The role of ROS and caspases in TRAIL-induced apoptosis and necroptosis in human pancreatic cancer cells2015
- Author(s)
  Harada M., Harashima N.
- Organizer
  19th JACI & 23rd MMCB, がん免疫療法・マクロファージ国際会議2015
- Place of Presentation
  東京大学（東京）
- Year and Date
  2015-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] HIF-2alpha regulates susceptibility of human pancreatic cancer cells to TRAIL- and T cell-mediated cytotoxicity via survivin2015
- Author(s)
  原嶋奈々江、秋元美穂、竹永啓三、原田守
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋国際会議場（愛知）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Bcl-2ファミリー阻害剤併用によるヒト前立腺癌細胞のDocetaxel感受性の増強2014
- Author(s)
  玉木宏樹、西村信弘、原嶋奈々江、原田守、直良浩司
- Organizer
  日本薬学会第134年会
- Place of Presentation
  ホテル日航熊本、鶴屋ホール、熊本大学他（熊本）
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Persistent antitumor immunity after the combination therapy with low-dose chemotherapy and anti-CD137 (4-1BB) antibody2013
- Author(s)
  頓宮美樹、原嶋奈々江、山田高也、岡野慎士、玉田耕治、原田守
- Organizer
  第72回日本癌学会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Mechanisms of an HSP-70 inhibitor pifithrin-mu to enhance TRAIL-induced apoptosis of pancreatic cancer cells2013
- Author(s)
  門馬浩行、原嶋奈々江、波里瑶子、田島義証、原田守
- Organizer
  第72回日本癌学会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] 膵癌細胞に対するTRAILと新規HSP70阻害剤pifithrin-muの併用効果と作用機序2013
- Author(s)
  門馬浩行, 原嶋奈々江, 木谷昭彦, 西健, 川畑康成,　矢野誠司,　田島義証
- Organizer
  第44回日本膵臓学会
- Place of Presentation
  仙台国際センター（仙台）
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Poly(I:C), an innate adjuvant receptor ligand, can induce the antitumor effects on human breast cancer cells2013
- Author(s)
  Touko Inao, Nanae Harashima, Yutaka Yamamoto, Mamoru Harada, Hirotaka Iwase
- Organizer
  36th Annual SABCS
- Place of Presentation
  San Antonio (U.S.A)
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Restoration of the TRAIL susceptibility of human pancreatic cancer cells by inhibition of Bcl-xL2013
- Author(s)
  原嶋奈々江、波里瑶子、門馬浩行、田島義証、原田守
- Organizer
  第72回日本癌学会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] HSP70阻害剤pifithrin-muがPanc-1膵癌細胞に対するTRAIL誘導性アポトーシスを増強する2013
- Author(s)
  門馬浩行、原嶋奈々江、波里瑶子、田島義証、原田守
- Organizer
  第17回日本がん免疫学会
- Place of Presentation
  ANAクラウンプラザホテル宇部（山口）
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Long-lasting suppression of CT26 growth after low-dose chemotherapy with cyclophosphamide plus gemcitabine, followed by anti-CD137 antibody2013
- Author(s)
  原田守、岡野慎士、玉田耕治、原嶋奈々江
- Organizer
  第42回日本免疫学会
- Place of Presentation
  幕張メッセ（千葉県幕張市）
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Poly(I:C)トランスフェクションによるROS産生を伴った癌細胞死誘導とその活性化経路2013
- Author(s)
  原嶋奈々江、岡野慎士、原田守
- Organizer
  第17回日本がん免疫学会
- Place of Presentation
  ANAクラウンプラザホテル宇部（山口）
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] 低用量chemotherapyと抗CD137抗体の併用により誘導される持続的な抗腫瘍免疫応答2013
- Author(s)
  頓宮美樹、原嶋奈々江、山田高也、岡野慎士、玉田耕治、原田守
- Organizer
  第17回日本がん免疫学会
- Place of Presentation
  ANAクラウンプラザホテル宇部（山口）
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] A novel HSP-70 inhibitor pifithrin-mu enhances the antitumor effect of radiation on human prostate cancer2013
- Author(s)
  関原和正、原嶋奈々江、内田伸恵、猪俣泰典、原田守
- Organizer
  第72回日本癌学会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] ヒト乳癌細胞の抗癌剤抵抗性におけるオートファジーの役割2012
- Author(s)
  稲尾瞳子, 原嶋奈々江他
- Organizer
  第20回日本乳癌学会
- Place of Presentation
  熊本市民会館他(熊本)
- Year and Date
  2012-06-30
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] HSP70 および autophagy 阻害剤 pifithrin-mu はTRAIL によるヒト膵癌細胞の apoptosisを増強する2012
- Author(s)
  門馬浩行, 原嶋奈々江他
- Organizer
  第16回日本がん免疫学会
- Place of Presentation
  北海道大学学術交流会館(北海道札幌市)
- Year and Date
  2012-07-26
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] Poly(I:C) トランスフェクションによるヒト腎癌細胞でのROSの産生とアポトーシスの誘導2012
- Author(s)
  原嶋奈々江　他
- Organizer
  第16回日本がん免疫学会
- Place of Presentation
  北海道大学学術交流会館（札幌市）
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] Inhibition of autophagy augments cancer cell death induced by an adjuvant receptor ligand, poly(I:C)2012
- Author(s)
  原嶋奈々江他
- Organizer
  第71回日本癌学会
- Place of Presentation
  ホテルロイトン札幌(北海道札幌市)
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] Inhibition of autophagy augments cancer cell death induced by an adjuvant receptor ligand, poly(I:C)2012
- Author(s)
  原嶋奈々江　他
- Organizer
  第71回日本癌学会
- Place of Presentation
  ホテルロイトン札幌（札幌市）
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] Effect of pifithrin-mu, a new HSP70 and autophagy inhibitor, on TRAIL-induced apoptosis of pancreatic cancer cells2012
- Author(s)
  門馬浩行, 原嶋奈々江他
- Organizer
  第71回日本癌学会
- Place of Presentation
  ホテルロイトン札幌(北海道札幌市)
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] Poly(I:C) トランスフェクションによるヒト腎癌細胞での ROSの産生とアポトーシスの誘導2012
- Author(s)
  原嶋奈々江他
- Organizer
  第16回日本がん免疫学会
- Place of Presentation
  北海道大学学術交流会館(北海道札幌市)
- Year and Date
  2012-07-28
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] 膵臓癌細胞に対する TRAIL と HSP70 阻害剤pifithrin-mu 併用による抗腫瘍効果2012
- Author(s)
  門馬浩行, 原嶋奈々江他
- Organizer
  第43回日本膵臓学会
- Place of Presentation
  ホテルメトリポリタン山形(山形)
- Year and Date
  2012-06-29
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] 乳癌細胞に発現するアジュバント受容体を利用したimmunogenic cancer cell death の誘導2011
- Author(s)
  原嶋奈々江他
- Organizer
  第15回日本がん免疫学会
- Place of Presentation
  千里ライフサイエンスセンタービル(大阪)
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] Apoptosis and ROS production in poly(I:C)-transfected human renal cell carcinoma2011
- Author(s)
  原嶋奈々江他
- Organizer
  第40回日本免疫学会
- Place of Presentation
  幕張メッセ(千葉)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] Role of autophagy in apoptosis of human cancer cells after stimulation through innate adjuvant receptors2011
- Author(s)
  原田守,原嶋奈々江他
- Organizer
  第40回日本免疫学会
- Place of Presentation
  幕張メッセ(千葉)
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] Apoptosis and ROS production in poly(I:C)-transfected human renal cell carcinoma2011
- Author(s)
  原嶋奈々江　他
- Organizer
  第40回日本免疫学会
- Place of Presentation
  幕張メッセ（千葉）
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] Poly(I:C) transfection により誘導されるヒト乳癌細胞でのアポトーシスとオートファジー2011
- Author(s)
  稲尾瞳子, 原嶋奈々江他
- Organizer
  第19回日本乳癌学会
- Place of Presentation
  仙台国際センター(宮城)
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] Anti-tumor effect and autophagy in human breast cancer cells after the transfection with poly(I:C)2011
- Author(s)
  稲尾瞳子, 原嶋奈々江他
- Organizer
  第70回日本癌学会
- Place of Presentation
  名古屋国際会議場(愛知)
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] 乳癌細胞に発現するアジュバント受容体を利用した immunogenic cancer cell death の誘導2011
- Author(s)
  原嶋奈々江　他
- Organizer
  第15回日本がん免疫学会
- Place of Presentation
  千里ライフサイエンスセンタービル（大阪）
- Data Source
  KAKENHI-PROJECT-23701074
[Presentation] TLR3リガンド刺激により誘導されるtype-I IFNを介する前立腺癌細胞の細胞死2009
- Author(s)
  原嶋奈々江
- Organizer
  第68回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20790930
[Presentation] TLR3リガンド刺激により誘導されるtype-I IFNを介する前立腺癌細胞の細胞死2009
- Author(s)
  原嶋奈々江
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-20790930
[Presentation] 同種造血幹細胞移植後の腎細胞癌患者由来T細胞が認識する新規腫瘍抗原の同定とその発現解析2008
- Author(s)
  原嶋奈々江
- Organizer
  第12回基盤的癌免疫研究会
- Place of Presentation
  埼玉
- Year and Date
  2008-07-02
- Data Source
  KAKENHI-PROJECT-20790930
[Presentation] 同種造血幹細胞移植後の腎細胞癌患者由来T細胞が認識する新規腫瘍抗原の同定とその発現解析2008
- Author(s)
  原嶋奈々江
- Organizer
  第12回基盤的癌免疫研究会総会
- Place of Presentation
  埼玉
- Year and Date
  2008-07-02
- Data Source
  KAKENHI-PROJECT-20790930
[Presentation] Autophagy阻害剤を用いたヒト膵癌に対するTRAILの抗腫瘍効果増強の検討
- Author(s)
  門馬浩行，原田守，波里瑶子，原嶋奈々江，高井清江，木谷昭彦，林彦多，川畑康成，矢野誠司，田島義証
- Organizer
  第69回　日本消化器外科学会総会
- Place of Presentation
  ホテルハマツ/郡山市民文化センター（郡山市、福島）
- Year and Date
  2014-07-16 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Autophagy inhibitors enhance TRAIL-Induced antitumor effects on human pancreatic cancer cells
- Author(s)
  Monma H, Harashima N, Hari Y, Kishi S, Tajima Y, Harada M
- Organizer
  45th Anniversary Meeting of APA (American pancreatic association)　/JPS(日本膵臓学会)
- Place of Presentation
  Hapuna Beach Prince Hotel, Big Island, Hawaii, U.S.A.
- Year and Date
  2014-11-05 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Inhibition of HIF-2alpha sensitizes human pancreatic cancer cells to TRAIL
- Author(s)
  原嶋奈々江、波里瑶子、門馬浩行、秋元美穂、竹永啓三、田島義証、原田守
- Organizer
  第73回日本癌学会
- Place of Presentation
  パシフィコ横浜（横浜市、神奈川）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] HIF-2alphaの阻害はヒト膵がん細胞のTRAIL感受性を増強する
- Author(s)
  原嶋奈々江、秋元美穂、竹永啓三、原田守
- Organizer
  第12回がんとハイポキシア研究会
- Place of Presentation
  ホテルマリターレ創世佐賀（佐賀市）
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Bcl-2 family inhibitor ABT-263 unveils the resistance to TRAIL-induced apoptosis in human pancreatic cancer cells
- Author(s)
  波里瑶子、原嶋奈々江、門馬浩行、田島義証、原田守
- Organizer
  第73回日本癌学会
- Place of Presentation
  パシフィコ横浜（横浜市、神奈川）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] ヒト膵癌細胞に対するTRAILとchloroquineの併用効果の検討
- Author(s)
  門馬浩行、原嶋奈々江、波里瑶子、田島義証、原田守
- Organizer
  第18回日本がん免疫学会
- Place of Presentation
  ひめぎんホール（松山市、愛媛）
- Year and Date
  2014-07-30 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] 低酸素誘導因子hypoxia-inducible factor阻害によるヒト膵癌細胞のTRAIL抵抗性の増強
- Author(s)
  原嶋奈々江、波里瑶子、門馬浩行、秋元美穂、竹永啓三、原田守
- Organizer
  第18回日本がん免疫学会
- Place of Presentation
  ひめぎんホール（松山市、愛媛）
- Year and Date
  2014-07-30 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Bcl-2 family阻害剤併用によるヒト膵癌細胞のTRAIL抵抗性の克服
- Author(s)
  波里瑶子、原嶋奈々江、門馬浩行、田島義証、原田守
- Organizer
  第18回日本がん免疫学会
- Place of Presentation
  ひめぎんホール（松山市、愛媛）
- Year and Date
  2014-07-30 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Combination of low-dose and intermittent chemotherapy with cyclophosphamide and gemcitabine restores efficacy of anti-CD137 antibody therapy at the late tumor-bearing state
- Author(s)
  Harada M, Tamada K, Harashima N
- Organizer
  第43回日本免疫学会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] Bcl-2 family inhibitors effectively sensitize human pancreatic cancer cells to TRAIL
- Author(s)
  Hari Y, Harashima N, Kidani A, Hayashi H, Kawabata Y, Harada M, Yano S, Tajima Y
- Organizer
  45th Anniversary Meeting of APA (American pancreatic association)　/JPS(日本膵臓学会)
- Place of Presentation
  Hapuna Beach Prince Hotel, Big Island, Hawaii, U.S.A.
- Year and Date
  2014-11-05 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-25430150
[Presentation] ABT-263 sensitizes PC3 prostate cancer cells to docetaxel
- Author(s)
  玉木宏樹、原嶋奈々江、原田守
- Organizer
  第73回日本癌学会
- Place of Presentation
  パシフィコ横浜（横浜市、神奈川）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25430150

1. KANNAGI Mari (80202034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 大橋貴 (10282774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 原田守

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
4. 今村龍

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 川内秀之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Harashima Nanae 原嶋 奈々江

HARASHIMA Nanae 原嶋 奈々江

原嶋 奈々江 ハラシマ ナナエ

Research Projects

Research Products

Co-Researchers

Restoration of immune susceptibility to cancer cells regulated by autophagy and hypoxic responsesPrincipal Investigator

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Cancer cell death and autophagy induced by the signaling of immune adjuvant receptorsPrincipal Investigator

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Enhancing effect in the expression of tumor antigens and T-cell sensitivity against tumor cells after treatment with epigenetic drugs.Principal Investigator

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Anti-viral immuno therapeutic approaches for adult T-cell leukemia

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ラットモデルを用いたヒト成人T細胞白血病に対する免疫療法の開発

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[Journal Article] Detection of an immunogenic HERV-E envelope with selective expression in clear cell kidney cancer2016

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[Journal Article] The roles of ROS and caspases in TRAIL-Induced apoptosis and necroptosis in human pancreatic cancer cells2015

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[Journal Article] Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state.2015

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NAID

Data Source

[Journal Article] Identification of programmed death ligand 1-derived peptides capable of inducing cancer-reactive cytotoxic T lymphocytes from HLA-A24+ patients with renal cell carcinoma2015

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[Journal Article] Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells2015

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[Journal Article] Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition2014

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[Journal Article] Identification of erythropoietin receptor-derived peptides having the potential to induce cancer-reactive cytotoxic T lymphocytes from HLA-A24+ patients with renal cell carcinoma.2014

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[Journal Article] Transfection of poly(I:C) can induce ROS-triggered apoptosis and IFN-&#61538;-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system2014

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[Journal Article] Pifithrin-mu, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells2013

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Harashima Nanae 原嶋奈々江

HARASHIMA Nanae 原嶋奈々江

原嶋奈々江ハラシマナナエ

[Journal Article] Transfection of poly(I:C) can induce ROS-triggered apoptosis and IFN--mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system2014